ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	9.72704442
2	spermatid development (GO:0007286)	9.70526773
3	epithelial cilium movement (GO:0003351)	9.68437650
4	reproduction (GO:0000003)	9.56603072
5	motile cilium assembly (GO:0044458)	9.54505327
6	cilium or flagellum-dependent cell motility (GO:0001539)	9.01758275
7	regulation of cilium movement (GO:0003352)	8.27273765
8	cilium movement (GO:0003341)	7.78074523
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.48400837
10	single fertilization (GO:0007338)	7.48058849
11	negative regulation of inclusion body assembly (GO:0090084)	7.01988462
12	synaptonemal complex organization (GO:0070193)	6.99407416
13	male meiosis (GO:0007140)	6.98290818
14	piRNA metabolic process (GO:0034587)	6.90455520
15	sperm capacitation (GO:0048240)	6.88955649
16	synaptonemal complex assembly (GO:0007130)	6.86713291
17	spermatogenesis (GO:0007283)	6.76360600
18	male gamete generation (GO:0048232)	6.73896488
19	microtubule depolymerization (GO:0007019)	6.63282035
20	organic cation transport (GO:0015695)	6.54693124
21	fertilization (GO:0009566)	6.33375862
22	gamete generation (GO:0007276)	6.19722762
23	regulation of inclusion body assembly (GO:0090083)	5.89025591
24	calcium ion-dependent exocytosis (GO:0017156)	5.72386414
25	germ cell development (GO:0007281)	5.38479949
26	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.36328736
27	chromosome condensation (GO:0030261)	5.20259028
28	spermatid nucleus differentiation (GO:0007289)	5.17484150
29	glycerol ether metabolic process (GO:0006662)	5.17448852
30	cell recognition (GO:0008037)	5.11803951
31	ventricular system development (GO:0021591)	4.94343126
32	DNA packaging (GO:0006323)	4.91778513
33	regulation of microtubule-based movement (GO:0060632)	4.87677984
34	multicellular organismal reproductive process (GO:0048609)	4.86620423
35	ether metabolic process (GO:0018904)	4.78593805
36	chromosome organization involved in meiosis (GO:0070192)	4.72276301
37	male meiosis I (GO:0007141)	4.69295465
38	seminiferous tubule development (GO:0072520)	4.57561132
39	DNA methylation involved in gamete generation (GO:0043046)	4.56051950
40	microtubule severing (GO:0051013)	4.45685705
41	chaperone-mediated protein complex assembly (GO:0051131)	4.17898116
42	left/right pattern formation (GO:0060972)	4.14176100
43	meiotic nuclear division (GO:0007126)	4.13456755
44	sexual reproduction (GO:0019953)	4.11529870
45	single strand break repair (GO:0000012)	3.99309548
46	multicellular organismal development (GO:0007275)	3.93715872
47	sequestering of actin monomers (GO:0042989)	3.87340117
48	meiosis I (GO:0007127)	3.74910922
49	protein K11-linked deubiquitination (GO:0035871)	3.49854222
50	genitalia morphogenesis (GO:0035112)	3.48961443
51	microtubule polymerization or depolymerization (GO:0031109)	3.44630476
52	protein polyglutamylation (GO:0018095)	3.36122028
53	regulation of spindle checkpoint (GO:0090231)	3.33249051
54	monoubiquitinated protein deubiquitination (GO:0035520)	3.27774685
55	meiotic cell cycle (GO:0051321)	3.26057743
56	protein localization to cilium (GO:0061512)	3.24978768
57	protein refolding (GO:0042026)	3.13745911
58	polyol catabolic process (GO:0046174)	3.13188481
59	nucleoside diphosphate phosphorylation (GO:0006165)	3.12057949
60	amino-acid betaine transport (GO:0015838)	3.11148990
61	carnitine transport (GO:0015879)	3.11148990
62	glycolytic process (GO:0006096)	3.05690178
63	alditol metabolic process (GO:0019400)	3.04535490
64	mitotic sister chromatid cohesion (GO:0007064)	3.02613472
65	interferon-gamma secretion (GO:0072643)	3.02343526
66	GTP biosynthetic process (GO:0006183)	3.01656883
67	nucleus organization (GO:0006997)	3.00784533
68	positive regulation of macrophage activation (GO:0043032)	2.96808963
69	carnitine transmembrane transport (GO:1902603)	2.94800128
70	synapsis (GO:0007129)	2.89182105
71	cilium organization (GO:0044782)	2.79338456
72	lactate metabolic process (GO:0006089)	2.78394790
73	cilium morphogenesis (GO:0060271)	2.74868589
74	RNA localization (GO:0006403)	2.72234484
75	cellular component assembly involved in morphogenesis (GO:0010927)	2.69979619
76	intraciliary transport (GO:0042073)	2.69574885
77	meiotic cell cycle process (GO:1903046)	2.69408800
78	cilium assembly (GO:0042384)	2.69239729
79	microtubule-based movement (GO:0007018)	2.69025218
80	RNA destabilization (GO:0050779)	2.68793012
81	UTP biosynthetic process (GO:0006228)	2.67541319
82	axoneme assembly (GO:0035082)	2.67280171
83	regulation of cilium assembly (GO:1902017)	2.65390171
84	glycerol metabolic process (GO:0006071)	2.59900077
85	polyamine biosynthetic process (GO:0006596)	2.57840862
86	centriole assembly (GO:0098534)	2.54826467
87	chromatin silencing (GO:0006342)	2.47519829
88	UTP metabolic process (GO:0046051)	2.44307767
89	gene silencing by RNA (GO:0031047)	2.41910771
90	fusion of sperm to egg plasma membrane (GO:0007342)	13.9232162
91	cell wall macromolecule catabolic process (GO:0016998)	13.8761254
92	cell wall macromolecule metabolic process (GO:0044036)	13.8761254
93	sperm motility (GO:0030317)	13.8070090
94	acrosome reaction (GO:0007340)	12.2328927
95	acrosome assembly (GO:0001675)	12.1537264
96	sperm-egg recognition (GO:0035036)	11.7402374
97	multicellular organism reproduction (GO:0032504)	11.1233827
98	binding of sperm to zona pellucida (GO:0007339)	10.6386081
99	plasma membrane fusion (GO:0045026)	10.6115848
100	cell-cell recognition (GO:0009988)	10.5003223

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	9.47699188
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.12505681
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.12465183
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.19083472
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.98706007
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.94859770
7	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.65821376
8	VDR_22108803_ChIP-Seq_LS180_Human	2.35642239
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.15172979
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15074502
11	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.14986405
12	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.12250184
13	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.06964071
14	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.02288402
15	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.90614175
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87773976
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78574971
18	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.75743180
19	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.74774301
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.73821560
21	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.72853321
22	STAT1_17558387_ChIP-Seq_HELA_Human	1.70331852
23	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63899593
24	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.60260940
25	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.57772714
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.57401326
27	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.56424908
28	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.54864821
29	KDM2B_26808549_Chip-Seq_REH_Human	1.53872025
30	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.52440983
31	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.51382824
32	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.45105503
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.37229305
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37229305
35	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.35099403
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34988389
37	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.34823985
38	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.32962022
39	P53_21459846_ChIP-Seq_SAOS-2_Human	1.32200379
40	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.31939351
41	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.28639562
42	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.27886008
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27759761
44	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.27129689
45	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26212067
46	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.25724317
47	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.24611438
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24026082
49	GF1_26923725_Chip-Seq_HPCs_Mouse	1.21549274
50	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20739656
51	TAF15_26573619_Chip-Seq_HEK293_Human	1.20354583
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18648317
53	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.16077166
54	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.15391573
55	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.15048398
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12784742
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12784742
58	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11400676
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11292911
60	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.10588375
61	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09764393
62	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09688321
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08490004
64	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07625755
65	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.06999624
66	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.06876723
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.05908553
68	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.03895504
69	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.02229873
70	ERG_20517297_ChIP-Seq_VCAP_Human	1.01836832
71	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.01792208
72	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.01490478
73	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.01359865
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00847466
75	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.00685757
76	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99522693
77	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.98264118
78	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.97725159
79	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97629783
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97467707
81	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.97063612
82	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.97060587
83	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.96607679
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96441040
85	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.96271499
86	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96263174
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95141682
88	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.94686077
89	SOX9_26525672_Chip-Seq_HEART_Mouse	0.94038274
90	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.92516009
91	P300_18555785_Chip-Seq_ESCs_Mouse	0.91083870
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.90709607
93	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.90524474
94	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.89907842
95	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.89703470
96	NFYB_21822215_ChIP-Seq_K562_Human	0.89035149
97	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.88876785
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.88843887
99	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.87800320
100	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.87270679

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	6.07185698
2	MP0001929_abnormal_gametogenesis	5.54401276
3	MP0008877_abnormal_DNA_methylation	4.15553098
4	MP0002210_abnormal_sex_determination	3.35418572
5	MP0002161_abnormal_fertility/fecundity	3.29178124
6	MP0005670_abnormal_white_adipose	2.96340105
7	MP0001145_abnormal_male_reproductive	2.83930898
8	MP0000653_abnormal_sex_gland	2.45700674
9	MP0002653_abnormal_ependyma_morphology	2.20305127
10	MP0005410_abnormal_fertilization	16.6125086
11	MP0002160_abnormal_reproductive_system	1.66105261
12	MP0004233_abnormal_muscle_weight	1.56885339
13	MP0003646_muscle_fatigue	1.33931707
14	MP0005623_abnormal_meninges_morphology	1.24485645
15	MP0002234_abnormal_pharynx_morphology	1.24163987
16	MP0002282_abnormal_trachea_morphology	1.19600161
17	MP0001765_abnormal_ion_homeostasis	1.13806581
18	MP0001984_abnormal_olfaction	1.10776353
19	MP0009046_muscle_twitch	0.90676428
20	MP0005647_abnormal_sex_gland	0.88800866
21	MP0005389_reproductive_system_phenotype	0.78978785
22	MP0008058_abnormal_DNA_repair	0.77538167
23	MP0003011_delayed_dark_adaptation	0.75287602
24	MP0008995_early_reproductive_senescence	0.72829461
25	MP0003115_abnormal_respiratory_system	0.69276267
26	MP0005636_abnormal_mineral_homeostasis	0.63563338
27	MP0003329_amyloid_beta_deposits	0.60814957
28	MP0005666_abnormal_adipose_tissue	0.56009882
29	MP0002102_abnormal_ear_morphology	0.49252601
30	MP0001324_abnormal_eye_pigmentation	0.48531467
31	MP0002269_muscular_atrophy	0.48433989
32	MP0003878_abnormal_ear_physiology	0.45744107
33	MP0005377_hearing/vestibular/ear_phenot	0.45744107
34	MP0005551_abnormal_eye_electrophysiolog	0.45616843
35	MP0001764_abnormal_homeostasis	0.44995016
36	MP0004036_abnormal_muscle_relaxation	0.44179837
37	MP0003699_abnormal_female_reproductive	0.43586389
38	MP0002736_abnormal_nociception_after	0.42918433
39	MP0002928_abnormal_bile_duct	0.41635867
40	MP0000358_abnormal_cell_content/	0.41409789
41	MP0005253_abnormal_eye_physiology	0.41119513
42	MP0010094_abnormal_chromosome_stability	0.40573902
43	MP0001293_anophthalmia	0.39204823
44	MP0006036_abnormal_mitochondrial_physio	0.36356228
45	MP0000534_abnormal_ureter_morphology	0.34949878
46	MP0003633_abnormal_nervous_system	0.34365204
47	MP0002139_abnormal_hepatobiliary_system	0.34326765
48	MP0005397_hematopoietic_system_phenotyp	0.31912825
49	MP0001545_abnormal_hematopoietic_system	0.31912825
50	MP0005391_vision/eye_phenotype	0.31422750
51	MP0009115_abnormal_fat_cell	0.31359764
52	MP0001968_abnormal_touch/_nociception	0.30417626
53	MP0002971_abnormal_brown_adipose	0.30364141
54	MP0000604_amyloidosis	0.29945169
55	MP0004811_abnormal_neuron_physiology	0.29920590
56	MP0004019_abnormal_vitamin_homeostasis	0.29836523
57	MP0003183_abnormal_peptide_metabolism	0.28598728
58	MP0004133_heterotaxia	0.27736521
59	MP0003942_abnormal_urinary_system	0.26702141
60	MP0003631_nervous_system_phenotype	0.26141134
61	MP0003787_abnormal_imprinting	0.25683610
62	MP0008057_abnormal_DNA_replication	0.24087851
63	MP0003861_abnormal_nervous_system	0.24031745
64	MP0000569_abnormal_digit_pigmentation	0.23845717
65	MP0002152_abnormal_brain_morphology	0.23755551
66	MP0004270_analgesia	0.23529292
67	MP0009278_abnormal_bone_marrow	0.23443605
68	MP0001119_abnormal_female_reproductive	0.22771608
69	MP0003948_abnormal_gas_homeostasis	0.22415204
70	MP0003879_abnormal_hair_cell	0.22256446
71	MP0002169_no_abnormal_phenotype	0.21975670
72	MP0002873_normal_phenotype	0.21718954
73	MP0003786_premature_aging	0.21311644
74	MP0003111_abnormal_nucleus_morphology	0.20606091
75	MP0000462_abnormal_digestive_system	0.19724434
76	MP0001730_embryonic_growth_arrest	0.18491208
77	MP0004043_abnormal_pH_regulation	0.18442773
78	MP0004742_abnormal_vestibular_system	0.18252512
79	MP0008875_abnormal_xenobiotic_pharmacok	0.18027253
80	MP0003959_abnormal_lean_body	0.17806309
81	MP0005375_adipose_tissue_phenotype	0.17676810
82	MP0005365_abnormal_bile_salt	0.17533996
83	MP0010307_abnormal_tumor_latency	0.17408900
84	MP0006035_abnormal_mitochondrial_morpho	0.17007074
85	MP0003950_abnormal_plasma_membrane	0.16832269
86	MP0002092_abnormal_eye_morphology	0.16533366
87	MP0005423_abnormal_somatic_nervous	0.16027739
88	MP0002295_abnormal_pulmonary_circulatio	0.15414067
89	MP0003283_abnormal_digestive_organ	0.15342252
90	MP0002572_abnormal_emotion/affect_behav	0.15302525
91	MP0002229_neurodegeneration	0.15167201
92	MP0008569_lethality_at_weaning	0.15014623
93	MP0002909_abnormal_adrenal_gland	0.14165167
94	MP0008007_abnormal_cellular_replicative	0.13930696
95	MP0001270_distended_abdomen	0.13839209
96	MP0006072_abnormal_retinal_apoptosis	0.13741592
97	MP0001529_abnormal_vocalization	0.13597364
98	MP0002693_abnormal_pancreas_physiology	0.13592932
99	MP0005195_abnormal_posterior_eye	0.13313232
100	MP0000001_mammalian_phenotype	0.12969294

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	9.49058775
2	Abnormal respiratory epithelium morphology (HP:0012253)	9.45916052
3	Abnormal respiratory motile cilium morphology (HP:0005938)	9.45916052
4	Abnormal ciliary motility (HP:0012262)	7.57955543
5	Rhinitis (HP:0012384)	7.53356610
6	Chronic bronchitis (HP:0004469)	7.50319335
7	Infertility (HP:0000789)	6.90087759
8	Nasal polyposis (HP:0100582)	6.32497131
9	Abnormality of the nasal mucosa (HP:0000433)	5.18968608
10	Male infertility (HP:0003251)	4.49945386
11	Bronchitis (HP:0012387)	4.47378499
12	Bronchiectasis (HP:0002110)	4.38804645
13	Nephronophthisis (HP:0000090)	3.98837833
14	Abnormal spermatogenesis (HP:0008669)	3.51893536
15	Recurrent sinusitis (HP:0011108)	3.39191002
16	Recurrent otitis media (HP:0000403)	3.20945966
17	Abnormality of the renal medulla (HP:0100957)	2.98647620
18	Medial flaring of the eyebrow (HP:0010747)	2.69158803
19	Impulsivity (HP:0100710)	2.56808851
20	Molar tooth sign on MRI (HP:0002419)	2.53984752
21	Abnormality of midbrain morphology (HP:0002418)	2.53984752
22	Tubulointerstitial nephritis (HP:0001970)	2.51475950
23	Recurrent bronchitis (HP:0002837)	2.45417941
24	Tubular atrophy (HP:0000092)	2.42343197
25	Azoospermia (HP:0000027)	2.28156431
26	Gonadotropin excess (HP:0000837)	2.26725232
27	Tubulointerstitial abnormality (HP:0001969)	2.18147081
28	Cholecystitis (HP:0001082)	2.14820387
29	Abnormal gallbladder physiology (HP:0012438)	2.14820387
30	Dyschromatopsia (HP:0007641)	2.02323499
31	Absent/shortened dynein arms (HP:0200106)	13.7447433
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	13.7447433
33	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.0552422
34	Choroideremia (HP:0001139)	1.83021535
35	Spastic tetraparesis (HP:0001285)	1.81325620
36	Tubulointerstitial fibrosis (HP:0005576)	1.78101997
37	Decreased central vision (HP:0007663)	1.77464273
38	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.74988624
39	Postaxial foot polydactyly (HP:0001830)	1.73840338
40	Stage 5 chronic kidney disease (HP:0003774)	1.69138551
41	Abnormal biliary tract physiology (HP:0012439)	1.68466765
42	Bile duct proliferation (HP:0001408)	1.68466765
43	Abnormal drinking behavior (HP:0030082)	1.68347377
44	Polydipsia (HP:0001959)	1.68347377
45	Aplasia/Hypoplasia of the lens (HP:0008063)	1.65787550
46	Congenital primary aphakia (HP:0007707)	1.63724681
47	Gait imbalance (HP:0002141)	1.63515583
48	Neurofibrillary tangles (HP:0002185)	1.63029182
49	Congenital hepatic fibrosis (HP:0002612)	1.60696785
50	Abnormality of renal excretion (HP:0011036)	1.60216675
51	Heterotopia (HP:0002282)	1.55070962
52	Abnormality of the renal cortex (HP:0011035)	1.55002131
53	Hemorrhage of the eye (HP:0011885)	1.54237349
54	Congenital malformation of the right heart (HP:0011723)	1.52737507
55	Double outlet right ventricle (HP:0001719)	1.52737507
56	Postaxial hand polydactyly (HP:0001162)	1.48564789
57	Oculomotor apraxia (HP:0000657)	1.45893588
58	Bell-shaped thorax (HP:0001591)	1.45251635
59	Short ribs (HP:0000773)	1.43802248
60	Chronic sinusitis (HP:0011109)	1.43472830
61	Abnormality of permanent molar morphology (HP:0011071)	1.43395610
62	Abnormality of the dental root (HP:0006486)	1.43395610
63	Taurodontia (HP:0000679)	1.43395610
64	Fibular hypoplasia (HP:0003038)	1.42958805
65	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.42426526
66	Renal dysplasia (HP:0000110)	1.41910302
67	Nephrogenic diabetes insipidus (HP:0009806)	1.40792166
68	Easy fatigability (HP:0003388)	1.38725994
69	Facial cleft (HP:0002006)	1.37660501
70	Absent epiphyses (HP:0010577)	1.37360128
71	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.37360128
72	Abnormality of the dental pulp (HP:0006479)	1.34482366
73	Abnormality of the lower motor neuron (HP:0002366)	1.33383575
74	Abnormality of molar morphology (HP:0011070)	1.32835443
75	Abnormality of molar (HP:0011077)	1.32835443
76	Amyotrophic lateral sclerosis (HP:0007354)	1.32817226
77	Cerebellar dysplasia (HP:0007033)	1.32665679
78	Cerebral inclusion bodies (HP:0100314)	1.31615248
79	Asymmetric septal hypertrophy (HP:0001670)	1.31579069
80	Sensory axonal neuropathy (HP:0003390)	1.31455907
81	Vaginal atresia (HP:0000148)	1.30294783
82	Abnormal urine output (HP:0012590)	1.29616965
83	Fatigable weakness (HP:0003473)	1.29453420
84	Abnormality of the neuromuscular junction (HP:0003398)	1.29453420
85	Deformed sella turcica (HP:0002681)	1.28789255
86	Genital tract atresia (HP:0001827)	1.27541444
87	Cystic liver disease (HP:0006706)	1.25903692
88	Abnormality of dentin (HP:0010299)	1.25546982
89	Bundle branch block (HP:0011710)	1.25343973
90	Exercise-induced myalgia (HP:0003738)	1.25006416
91	Poor coordination (HP:0002370)	1.21707835
92	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.21533147
93	Hemiparesis (HP:0001269)	1.20797510
94	Constricted visual fields (HP:0001133)	1.20706844
95	Retinal dysplasia (HP:0007973)	1.19893855
96	Pancreatic fibrosis (HP:0100732)	1.17597498
97	Abnormality of saccadic eye movements (HP:0000570)	1.17515422
98	Supernumerary spleens (HP:0009799)	1.15351285
99	Nephropathy (HP:0000112)	1.14155811
100	Myoglobinuria (HP:0002913)	1.13629661

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	8.29631590
2	PDK4	8.29631590
3	TESK1	6.20009945
4	PDK2	5.35177296
5	PRKD3	4.97155637
6	ICK	4.49270084
7	WNK4	2.22341011
8	PTK2B	2.21744250
9	STK39	2.07798513
10	STK38	1.75523029
11	PNCK	1.67433170
12	NEK2	1.55433578
13	DYRK1B	1.54360167
14	PDK1	1.22771114
15	MAPK15	1.02825021
16	IRAK1	0.91566291
17	DYRK3	0.89052681
18	TYRO3	0.86901498
19	WNK1	0.83685166
20	PASK	0.80532879
21	PDPK1	0.76361135
22	CCNB1	0.70834142
23	RIPK4	0.70154482
24	TESK2	0.67388839
25	CHEK2	0.59450192
26	MAP2K6	0.57749722
27	STK3	0.55588802
28	TTK	0.54642274
29	PINK1	0.53953986
30	LMTK2	0.44478638
31	IRAK2	0.44262168
32	EEF2K	0.43235093
33	MUSK	0.43063228
34	PAK1	0.42620545
35	NTRK2	0.39889868
36	PLK4	0.39587556
37	CAMK1G	0.39044487
38	PRKCG	0.38213740
39	MAP3K10	0.35884035
40	STK38L	0.34806789
41	CHEK1	0.34488437
42	PAK2	0.24832292
43	ATM	0.23847632
44	MARK2	0.23227287
45	CAMKK1	0.22492824
46	MTOR	0.21907797
47	ATR	0.20109424
48	PAK4	0.19515641
49	BRSK2	0.19376444
50	NEK6	0.19224411
51	MAPKAPK5	0.17981467
52	WEE1	0.17764841
53	PRKAA1	0.17140007
54	PRKCZ	0.16748639
55	CDK15	0.16238013
56	CDK18	0.13850350
57	YES1	0.13441763
58	CDK12	0.13182170
59	BRAF	0.13160506
60	PRKG2	0.12956126
61	RPS6KB1	0.12858199
62	PRKCQ	0.12400018
63	CDK11A	0.11709146
64	PKN1	0.10573296
65	PIK3CG	0.10362106
66	PLK1	0.09231896
67	CDK14	0.08223847
68	PRKG1	0.07383228
69	BRSK1	0.06848504
70	WNK3	0.06841798
71	CSNK2A1	0.06294773
72	RPS6KA1	0.06162457
73	CSF1R	0.05242890
74	PRKACG	0.05200623
75	MARK3	0.05156196
76	CAMK2A	0.05061417
77	GSK3B	0.04820454
78	CDC7	0.03818887
79	CSNK1D	0.03368251
80	CASK	0.03202473
81	PRKCD	0.02570346
82	PRKCB	0.01737924
83	EPHB1	0.01683309
84	STK10	0.01464043
85	PAK6	0.01452798
86	CDK6	0.01273944
87	PRKCA	0.01077408
88	CSNK2A2	0.00885795
89	MAP3K1	0.00716856
90	STK11	0.00511506
91	CDK1	0.00287134
92	PRKACB	-0.0343637
93	RPS6KA3	-0.0308508
94	PRKACA	-0.0171842
95	CLK1	-0.0126757
96	MST1R	-0.0120488
97	AURKA	-0.0111793
98	EGFR	-0.0105941
99	CDK2	-0.0091083
100	MAPK8	-0.0003597

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.49959203
2	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.41307895
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.95313387
4	Pyruvate metabolism_Homo sapiens_hsa00620	3.63116044
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.14238408
6	Linoleic acid metabolism_Homo sapiens_hsa00591	3.03737726
7	Propanoate metabolism_Homo sapiens_hsa00640	2.85575735
8	Glucagon signaling pathway_Homo sapiens_hsa04922	2.68400294
9	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.54539857
10	Basal transcription factors_Homo sapiens_hsa03022	2.29963362
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.19301576
12	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.19097175
13	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.97776567
14	Glycerolipid metabolism_Homo sapiens_hsa00561	1.96544699
15	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.88830407
16	PPAR signaling pathway_Homo sapiens_hsa03320	1.88290703
17	Pentose phosphate pathway_Homo sapiens_hsa00030	1.72969862
18	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.70200480
19	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.68405765
20	Amphetamine addiction_Homo sapiens_hsa05031	1.64255451
21	Oocyte meiosis_Homo sapiens_hsa04114	1.62507835
22	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.62405138
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.47090907
24	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.44751436
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.43897293
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.43531319
27	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.41705563
28	Mineral absorption_Homo sapiens_hsa04978	1.41405346
29	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.40782622
30	Fatty acid degradation_Homo sapiens_hsa00071	1.39597974
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.32002368
32	Carbon metabolism_Homo sapiens_hsa01200	1.31380978
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29500239
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.27329192
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27282606
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.20561391
37	Renin secretion_Homo sapiens_hsa04924	1.19229001
38	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.11886651
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08325506
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.07586999
41	Glutathione metabolism_Homo sapiens_hsa00480	1.00987683
42	Purine metabolism_Homo sapiens_hsa00230	0.99989197
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.99067850
44	Huntingtons disease_Homo sapiens_hsa05016	0.97980836
45	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.91204243
46	Insulin secretion_Homo sapiens_hsa04911	0.89423987
47	Antigen processing and presentation_Homo sapiens_hsa04612	0.86794248
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85020876
49	Long-term potentiation_Homo sapiens_hsa04720	0.84173814
50	mRNA surveillance pathway_Homo sapiens_hsa03015	0.82547288
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80919214
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.79875670
53	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.71114870
54	Bile secretion_Homo sapiens_hsa04976	0.70992684
55	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.70766901
56	Estrogen signaling pathway_Homo sapiens_hsa04915	0.68940828
57	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.68932501
58	RNA transport_Homo sapiens_hsa03013	0.67631846
59	Calcium signaling pathway_Homo sapiens_hsa04020	0.58309353
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.56984612
61	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.56308249
62	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55255516
63	Salivary secretion_Homo sapiens_hsa04970	0.54472569
64	ABC transporters_Homo sapiens_hsa02010	0.54347983
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.53444730
66	Pancreatic secretion_Homo sapiens_hsa04972	0.52744239
67	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.50855205
68	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.50099643
69	Legionellosis_Homo sapiens_hsa05134	0.48466176
70	Sulfur metabolism_Homo sapiens_hsa00920	0.47818398
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.47205191
72	Protein digestion and absorption_Homo sapiens_hsa04974	0.46064398
73	Renin-angiotensin system_Homo sapiens_hsa04614	0.43837413
74	Metabolic pathways_Homo sapiens_hsa01100	0.41876391
75	Taste transduction_Homo sapiens_hsa04742	0.40247335
76	Gastric acid secretion_Homo sapiens_hsa04971	0.40178751
77	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.38962741
78	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.37837722
79	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37496496
80	AMPK signaling pathway_Homo sapiens_hsa04152	0.37327347
81	VEGF signaling pathway_Homo sapiens_hsa04370	0.37309080
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37120185
83	Endocytosis_Homo sapiens_hsa04144	0.35752378
84	Circadian entrainment_Homo sapiens_hsa04713	0.35470593
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.34541588
86	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.34223217
87	Cocaine addiction_Homo sapiens_hsa05030	0.32907450
88	Alcoholism_Homo sapiens_hsa05034	0.31209090
89	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.30849719
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28820214
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.28303396
92	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.26780460
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.20286829
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.17340622
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.16458359
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.12813150
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.11103463
98	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.10426985
99	Retinol metabolism_Homo sapiens_hsa00830	0.04234944
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.03425701

SCP2D1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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