SCRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.59755058
2central nervous system myelination (GO:0022010)9.59755058
3fatty acid elongation (GO:0030497)7.14142234
4myelination (GO:0042552)6.17009952
5axon ensheathment (GO:0008366)6.09401275
6ensheathment of neurons (GO:0007272)6.09401275
7L-amino acid import (GO:0043092)5.96976538
8cholesterol biosynthetic process (GO:0006695)5.93638921
9amino acid import (GO:0043090)5.27060720
10sterol biosynthetic process (GO:0016126)5.18969505
11long-chain fatty acid biosynthetic process (GO:0042759)5.10718948
12isoprenoid biosynthetic process (GO:0008299)4.71972850
13oligodendrocyte differentiation (GO:0048709)4.71060902
14C4-dicarboxylate transport (GO:0015740)4.68583216
15response to methylmercury (GO:0051597)4.66186117
16postsynaptic membrane organization (GO:0001941)4.55970200
17regulation of collateral sprouting (GO:0048670)4.37566121
18behavioral response to nicotine (GO:0035095)4.26571628
19response to redox state (GO:0051775)4.24505958
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.20366481
21gamma-aminobutyric acid transport (GO:0015812)4.13136265
22myelination in peripheral nervous system (GO:0022011)4.06180593
23peripheral nervous system axon ensheathment (GO:0032292)4.06180593
24eye photoreceptor cell differentiation (GO:0001754)4.02200725
25photoreceptor cell differentiation (GO:0046530)4.02200725
26limb bud formation (GO:0060174)4.01572655
27negative regulation of neurotransmitter secretion (GO:0046929)3.96960241
28substantia nigra development (GO:0021762)3.96024657
29negative regulation of neurotransmitter transport (GO:0051589)3.95326682
30negative regulation of protein localization to cell surface (GO:2000009)3.93006496
31negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.92418392
32neuron cell-cell adhesion (GO:0007158)3.92309110
33long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.91858949
34presynaptic membrane assembly (GO:0097105)3.85253143
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.84605240
36glycerophospholipid catabolic process (GO:0046475)3.82202062
37transmission of nerve impulse (GO:0019226)3.67410057
38presynaptic membrane organization (GO:0097090)3.64443161
39long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.57221386
40import into cell (GO:0098657)3.48239687
41positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.43475518
42negative regulation of astrocyte differentiation (GO:0048712)3.42331995
43amyloid precursor protein metabolic process (GO:0042982)3.39636561
44dermatan sulfate biosynthetic process (GO:0030208)3.37920827
45fatty-acyl-CoA biosynthetic process (GO:0046949)3.37058621
46positive regulation of oligodendrocyte differentiation (GO:0048714)3.30094394
47auditory behavior (GO:0031223)3.29366178
48myelin maintenance (GO:0043217)3.28060768
49very long-chain fatty acid metabolic process (GO:0000038)3.25736872
50neurotransmitter uptake (GO:0001504)3.23016928
51response to pheromone (GO:0019236)3.22741598
52astrocyte development (GO:0014002)3.22597516
53activated T cell proliferation (GO:0050798)3.17506030
54fatty-acyl-CoA metabolic process (GO:0035337)3.15088592
55adhesion of symbiont to host cell (GO:0044650)3.12971541
56virion attachment to host cell (GO:0019062)3.12971541
57startle response (GO:0001964)3.11596374
58negative regulation of cytosolic calcium ion concentration (GO:0051481)3.10566354
59cerebral cortex radially oriented cell migration (GO:0021799)3.09578047
60dermatan sulfate metabolic process (GO:0030205)3.07404110
61positive regulation of neurological system process (GO:0031646)3.07265569
62creatine metabolic process (GO:0006600)3.06809694
63sulfation (GO:0051923)3.03142468
64asymmetric protein localization (GO:0008105)3.02044402
65nucleotide transmembrane transport (GO:1901679)3.01765805
66negative regulation of axon extension (GO:0030517)3.00635926
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98329055
68mechanosensory behavior (GO:0007638)2.97233547
69pyrimidine nucleobase catabolic process (GO:0006208)2.97182029
70response to lipoprotein particle (GO:0055094)2.96002156
71acidic amino acid transport (GO:0015800)2.95894828
72cellular response to epinephrine stimulus (GO:0071872)2.95426183
73regulation of neurotransmitter uptake (GO:0051580)2.93935062
74synaptic transmission, glutamatergic (GO:0035249)2.93338293
75protein palmitoylation (GO:0018345)2.93219034
76locomotory exploration behavior (GO:0035641)2.92788332
77cell proliferation in forebrain (GO:0021846)2.91602736
78neuronal action potential (GO:0019228)2.90544524
79potassium ion import (GO:0010107)2.90423907
80L-glutamate transport (GO:0015813)2.89607761
81regulation of phospholipid biosynthetic process (GO:0071071)2.89534722
82peripheral nervous system development (GO:0007422)2.87717251
83negative regulation of axonogenesis (GO:0050771)2.86027595
84somite development (GO:0061053)2.85196932
85ionotropic glutamate receptor signaling pathway (GO:0035235)2.84454184
86response to epinephrine (GO:0071871)2.84232683
87negative regulation of mast cell activation (GO:0033004)2.84154971
88protein polyglutamylation (GO:0018095)2.81726410
89axon development (GO:0061564)2.80276384
90establishment of mitochondrion localization (GO:0051654)2.79829788
91indole-containing compound catabolic process (GO:0042436)2.79283152
92indolalkylamine catabolic process (GO:0046218)2.79283152
93tryptophan catabolic process (GO:0006569)2.79283152
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78821936
95L-serine transport (GO:0015825)2.78748173
96glial cell differentiation (GO:0010001)2.78174569
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77959663
98limb development (GO:0060173)2.77565294
99appendage development (GO:0048736)2.77565294
100indolalkylamine metabolic process (GO:0006586)2.77414603
101response to auditory stimulus (GO:0010996)2.76807726
102regulation of action potential (GO:0098900)2.76555625
103acyl-CoA biosynthetic process (GO:0071616)2.75451296
104thioester biosynthetic process (GO:0035384)2.75451296
105glutamate receptor signaling pathway (GO:0007215)2.75028793
106apical protein localization (GO:0045176)2.73688770
107DNA deamination (GO:0045006)2.73658735
108water-soluble vitamin biosynthetic process (GO:0042364)2.73014662
109dendritic spine morphogenesis (GO:0060997)2.72937833
110chondroitin sulfate catabolic process (GO:0030207)2.71903336
111membrane depolarization during action potential (GO:0086010)2.71870136
112positive regulation of action potential (GO:0045760)2.71679096
113protein localization to synapse (GO:0035418)2.71194475
114serotonin metabolic process (GO:0042428)2.70155775
115nonmotile primary cilium assembly (GO:0035058)2.70084195
116Rap protein signal transduction (GO:0032486)2.69786222
117detection of light stimulus involved in visual perception (GO:0050908)2.69655650
118detection of light stimulus involved in sensory perception (GO:0050962)2.69655650
119L-fucose catabolic process (GO:0042355)2.69562255
120fucose catabolic process (GO:0019317)2.69562255
121L-fucose metabolic process (GO:0042354)2.69562255
122lateral sprouting from an epithelium (GO:0060601)2.69390383
123spinal cord development (GO:0021510)2.69049882
124cellular response to cholesterol (GO:0071397)2.68558361
125glycosylceramide metabolic process (GO:0006677)2.67381286
126positive regulation of potassium ion transmembrane transport (GO:1901381)2.67015183
127neuromuscular synaptic transmission (GO:0007274)2.66112156
128vocalization behavior (GO:0071625)2.65849067
129primary amino compound metabolic process (GO:1901160)2.65716457
130cranial nerve development (GO:0021545)2.65168941
131astrocyte differentiation (GO:0048708)2.64431151
132neural nucleus development (GO:0048857)2.64393769
133positive regulation of actin filament depolymerization (GO:0030836)2.63395444
134alcohol biosynthetic process (GO:0046165)2.63356043
135sphingomyelin metabolic process (GO:0006684)2.62033501
136magnesium ion transport (GO:0015693)2.61986473
137cerebellar granule cell differentiation (GO:0021707)2.61723388
138neuronal ion channel clustering (GO:0045161)2.59438116
139cellular response to sterol (GO:0036315)2.58288672
140positive regulation of mitochondrial fission (GO:0090141)2.57453013
141regulation of respiratory system process (GO:0044065)2.55799251
142neurotransmitter-gated ion channel clustering (GO:0072578)2.55437067
143retinal ganglion cell axon guidance (GO:0031290)2.55129641
144indole-containing compound metabolic process (GO:0042430)2.54696534
145negative regulation of glial cell differentiation (GO:0045686)2.54389992
146otic vesicle formation (GO:0030916)2.54016524
147nucleobase catabolic process (GO:0046113)2.53592823
148cellular response to hepatocyte growth factor stimulus (GO:0035729)2.53358900
149response to hepatocyte growth factor (GO:0035728)2.53358900
150positive regulation of meiosis (GO:0045836)2.51574467
151positive regulation of interleukin-17 production (GO:0032740)2.51418552
152reflex (GO:0060004)2.50721657
153regulation of lipoprotein metabolic process (GO:0050746)2.50668893
154negative regulation of telomere maintenance (GO:0032205)2.49405046
155peptidyl-tyrosine autophosphorylation (GO:0038083)2.48647793
156tryptophan metabolic process (GO:0006568)2.47238828
157epithelial cilium movement (GO:0003351)2.46972773
158mitochondrial respiratory chain complex I assembly (GO:0032981)2.46822356
159NADH dehydrogenase complex assembly (GO:0010257)2.46822356
160mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46822356
161chondrocyte development (GO:0002063)2.46282961
162regulation of oligodendrocyte differentiation (GO:0048713)2.45120009
163retinal cone cell development (GO:0046549)2.44972627
164detection of mechanical stimulus involved in sensory perception (GO:0050974)2.44790156
165axoneme assembly (GO:0035082)2.44744529
166negative regulation of myoblast differentiation (GO:0045662)2.44659519
167regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43804401
168proline transport (GO:0015824)2.43391520
169neuronal action potential propagation (GO:0019227)2.43321320
170positive regulation of glial cell differentiation (GO:0045687)2.42987111
171neuron-neuron synaptic transmission (GO:0007270)2.42636135
172adult walking behavior (GO:0007628)2.42612572
173nephron tubule morphogenesis (GO:0072078)2.42557358
174nephron epithelium morphogenesis (GO:0072088)2.42557358
175preassembly of GPI anchor in ER membrane (GO:0016254)2.42187292
176cilium morphogenesis (GO:0060271)2.41589743
177amyloid precursor protein catabolic process (GO:0042987)2.40994557
178photoreceptor cell development (GO:0042461)2.40492069
179spinal cord motor neuron differentiation (GO:0021522)2.40242379
180platelet dense granule organization (GO:0060155)2.39992156
181detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39784907
182adhesion of symbiont to host (GO:0044406)2.39076331
183protein neddylation (GO:0045116)2.38724620
184nucleotide transport (GO:0006862)2.38648686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.35057939
2AR_21572438_ChIP-Seq_LNCaP_Human3.15526967
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04826252
4ZNF274_21170338_ChIP-Seq_K562_Hela2.93502659
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.70288209
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59714499
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58463288
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58276691
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48672073
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.44097188
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.35701638
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21476666
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20780303
14EZH2_22144423_ChIP-Seq_EOC_Human2.20335545
15TAF15_26573619_Chip-Seq_HEK293_Human2.17418386
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16275583
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16275583
18IGF1R_20145208_ChIP-Seq_DFB_Human2.15993742
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10900921
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07686698
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06059483
22* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00369068
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95036856
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.94370109
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91969889
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85343268
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.85042409
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.83287015
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81124454
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80480331
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79441505
32ER_23166858_ChIP-Seq_MCF-7_Human1.75722916
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75497214
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71896723
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70881390
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70486038
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.70287462
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.70020974
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67199861
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60219617
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56869212
42BCAT_22108803_ChIP-Seq_LS180_Human1.55931490
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.55369341
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55160399
45P300_19829295_ChIP-Seq_ESCs_Human1.51193728
46AR_25329375_ChIP-Seq_VCAP_Human1.49999499
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49104712
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.48284733
49DROSHA_22980978_ChIP-Seq_HELA_Human1.47884272
50* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46043453
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.44808810
52RNF2_27304074_Chip-Seq_NSC_Mouse1.43009666
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41978450
54FUS_26573619_Chip-Seq_HEK293_Human1.37962115
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36351372
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35481922
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32281075
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32281075
59CBP_20019798_ChIP-Seq_JUKART_Human1.31981372
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31981372
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.31737936
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30161130
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28340979
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27539527
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27197398
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25287855
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.23410904
68TCF4_22108803_ChIP-Seq_LS180_Human1.22804275
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22187219
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21790816
71IRF1_19129219_ChIP-ChIP_H3396_Human1.19414547
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18990273
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18039462
74REST_21632747_ChIP-Seq_MESCs_Mouse1.17876569
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.16760866
76SMAD4_21799915_ChIP-Seq_A2780_Human1.15046849
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14235649
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14212977
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13374331
80STAT3_23295773_ChIP-Seq_U87_Human1.12329300
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11927200
82NANOG_19829295_ChIP-Seq_ESCs_Human1.11572058
83SOX2_19829295_ChIP-Seq_ESCs_Human1.11572058
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.11272571
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.11087312
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10831431
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.10722728
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09699330
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09405409
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08656788
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.08329766
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07694803
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06882156
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05696244
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05671334
96VDR_22108803_ChIP-Seq_LS180_Human1.04561254
97JUN_21703547_ChIP-Seq_K562_Human1.04536620
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04284991
99HTT_18923047_ChIP-ChIP_STHdh_Human1.04182626
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03554325
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02889850
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02432120
103P300_18555785_Chip-Seq_ESCs_Mouse1.02342809
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02002652
105SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01699351
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01610275
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00545353
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99948283
109* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99542299
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99478153
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99478153
112RUNX2_22187159_ChIP-Seq_PCA_Human0.99122981
113TCF4_23295773_ChIP-Seq_U87_Human0.98963755
114BP1_19119308_ChIP-ChIP_Hs578T_Human0.98904223
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.98618998
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98152111
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98129788
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97655834
119P53_22387025_ChIP-Seq_ESCs_Mouse0.96907123
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95454319
121RING1B_27294783_Chip-Seq_ESCs_Mouse0.95297976
122TP53_18474530_ChIP-ChIP_U2OS_Human0.95286319
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.95154117
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.94718707
125EWS_26573619_Chip-Seq_HEK293_Human0.94657067
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94234148
127* SOX2_21211035_ChIP-Seq_LN229_Gbm0.94064414
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.92878393
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91492232
130RXR_22108803_ChIP-Seq_LS180_Human0.91439767
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91106837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.56263718
2MP0003690_abnormal_glial_cell3.56613204
3MP0003880_abnormal_central_pattern3.45575568
4MP0002653_abnormal_ependyma_morphology3.36819440
5MP0004134_abnormal_chest_morphology3.18305510
6MP0003136_yellow_coat_color2.95846081
7MP0004742_abnormal_vestibular_system2.67900248
8MP0004885_abnormal_endolymph2.63412338
9MP0004270_analgesia2.60670633
10MP0001486_abnormal_startle_reflex2.58966418
11MP0003329_amyloid_beta_deposits2.57915812
12MP0001905_abnormal_dopamine_level2.35696187
13MP0003634_abnormal_glial_cell2.34729402
14MP0000569_abnormal_digit_pigmentation2.29380180
15MP0005171_absent_coat_pigmentation2.25914397
16MP0001529_abnormal_vocalization2.22370311
17MP0000778_abnormal_nervous_system2.21219870
18MP0002272_abnormal_nervous_system2.16425479
19MP0001485_abnormal_pinna_reflex2.16378475
20MP0003950_abnormal_plasma_membrane2.11726691
21MP0005423_abnormal_somatic_nervous2.10289804
22MP0008877_abnormal_DNA_methylation2.09118898
23MP0002064_seizures2.08437327
24MP0005409_darkened_coat_color2.03133359
25MP0000462_abnormal_digestive_system2.02055885
26MP0004142_abnormal_muscle_tone1.96998458
27MP0009745_abnormal_behavioral_response1.78873800
28MP0009250_abnormal_appendicular_skeleto1.77744208
29MP0004859_abnormal_synaptic_plasticity1.75607110
30MP0003632_abnormal_nervous_system1.72447170
31MP0003635_abnormal_synaptic_transmissio1.72306045
32MP0002102_abnormal_ear_morphology1.71857541
33MP0003787_abnormal_imprinting1.70636528
34MP0002638_abnormal_pupillary_reflex1.68239402
35MP0009046_muscle_twitch1.60330100
36MP0001440_abnormal_grooming_behavior1.58389759
37MP0001986_abnormal_taste_sensitivity1.56189925
38MP0002572_abnormal_emotion/affect_behav1.56169565
39MP0006292_abnormal_olfactory_placode1.56069562
40MP0002734_abnormal_mechanical_nocicepti1.54003989
41MP0008872_abnormal_physiological_respon1.52215696
42MP0006276_abnormal_autonomic_nervous1.51983414
43MP0005551_abnormal_eye_electrophysiolog1.50020833
44MP0001501_abnormal_sleep_pattern1.48801097
45MP0001963_abnormal_hearing_physiology1.43504198
46MP0002736_abnormal_nociception_after1.42456734
47MP0005174_abnormal_tail_pigmentation1.41954843
48MP0004133_heterotaxia1.39640351
49MP0009384_cardiac_valve_regurgitation1.38355164
50MP0003938_abnormal_ear_development1.38160046
51MP0003806_abnormal_nucleotide_metabolis1.37210545
52MP0001299_abnormal_eye_distance/1.36960437
53MP0002063_abnormal_learning/memory/cond1.36738487
54MP0002229_neurodegeneration1.35597416
55MP0000566_synostosis1.31510680
56MP0003011_delayed_dark_adaptation1.30952450
57MP0002837_dystrophic_cardiac_calcinosis1.30919364
58MP0005410_abnormal_fertilization1.28366290
59MP0000762_abnormal_tongue_morphology1.27672798
60MP0001502_abnormal_circadian_rhythm1.27339607
61MP0002882_abnormal_neuron_morphology1.26539977
62MP0002876_abnormal_thyroid_physiology1.25065787
63MP0001968_abnormal_touch/_nociception1.24061646
64MP0003631_nervous_system_phenotype1.23832904
65MP0002067_abnormal_sensory_capabilities1.23735245
66MP0001661_extended_life_span1.23587187
67MP0000604_amyloidosis1.23147970
68MP0001970_abnormal_pain_threshold1.21821008
69MP0002928_abnormal_bile_duct1.20920955
70MP0000955_abnormal_spinal_cord1.20803620
71MP0005646_abnormal_pituitary_gland1.17679610
72MP0000026_abnormal_inner_ear1.14702146
73MP0000383_abnormal_hair_follicle1.14262816
74MP0002752_abnormal_somatic_nervous1.14227736
75MP0008569_lethality_at_weaning1.13722038
76MP0002933_joint_inflammation1.12223946
77MP0005645_abnormal_hypothalamus_physiol1.12195900
78MP0002295_abnormal_pulmonary_circulatio1.11472158
79MP0009780_abnormal_chondrocyte_physiolo1.11430740
80MP0002282_abnormal_trachea_morphology1.10368945
81MP0010678_abnormal_skin_adnexa1.09805549
82MP0002160_abnormal_reproductive_system1.09703485
83MP0000647_abnormal_sebaceous_gland1.09559238
84MP0002066_abnormal_motor_capabilities/c1.09283741
85MP0003937_abnormal_limbs/digits/tail_de1.07876836
86MP0003633_abnormal_nervous_system1.07594574
87MP0005623_abnormal_meninges_morphology1.07337980
88MP0002733_abnormal_thermal_nociception1.07246657
89MP0005195_abnormal_posterior_eye1.04653817
90MP0002751_abnormal_autonomic_nervous1.03715506
91MP0005367_renal/urinary_system_phenotyp1.02670289
92MP0000516_abnormal_urinary_system1.02670289
93MP0003283_abnormal_digestive_organ1.00798680
94MP0005084_abnormal_gallbladder_morpholo1.00516248
95MP0002090_abnormal_vision1.00483646
96MP0005253_abnormal_eye_physiology0.98152494
97MP0005451_abnormal_body_composition0.94600608
98MP0000427_abnormal_hair_cycle0.94157192
99MP0001177_atelectasis0.93580195
100MP0004185_abnormal_adipocyte_glucose0.93362792
101MP0004147_increased_porphyrin_level0.92715522
102MP0000163_abnormal_cartilage_morphology0.92082985
103MP0002095_abnormal_skin_pigmentation0.91481204
104MP0004043_abnormal_pH_regulation0.91472769
105MP0000631_abnormal_neuroendocrine_gland0.91159024
106MP0005389_reproductive_system_phenotype0.90521004
107MP0006072_abnormal_retinal_apoptosis0.89623500
108MP0005386_behavior/neurological_phenoty0.88428835
109MP0004924_abnormal_behavior0.88428835
110MP0004145_abnormal_muscle_electrophysio0.88298867
111MP0002557_abnormal_social/conspecific_i0.86269087
112MP0005167_abnormal_blood-brain_barrier0.85337366
113MP0002735_abnormal_chemical_nociception0.84654131
114MP0002152_abnormal_brain_morphology0.82800855
115MP0003119_abnormal_digestive_system0.82486844
116MP0008789_abnormal_olfactory_epithelium0.81385327
117MP0003646_muscle_fatigue0.80765216
118MP0002938_white_spotting0.77169864
119MP0004215_abnormal_myocardial_fiber0.76870065
120MP0000372_irregular_coat_pigmentation0.76439333
121MP0005187_abnormal_penis_morphology0.72692132
122MP0001943_abnormal_respiration0.72510194
123MP0002184_abnormal_innervation0.72289922
124MP0001984_abnormal_olfaction0.71896125
125MP0004858_abnormal_nervous_system0.71397824
126MP0003385_abnormal_body_wall0.70806560
127MP0005388_respiratory_system_phenotype0.70805641
128MP0002133_abnormal_respiratory_system0.70805641
129MP0001958_emphysema0.70317133
130MP0004381_abnormal_hair_follicle0.69373068
131MP0000049_abnormal_middle_ear0.69201122
132MP0002108_abnormal_muscle_morphology0.68710866
133MP0003195_calcinosis0.67132630

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.10268286
2Irregular epiphyses (HP:0010582)5.52092346
3Small epiphyses (HP:0010585)5.27445294
4Neurofibrillary tangles (HP:0002185)4.79956152
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.71265075
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.71265075
7True hermaphroditism (HP:0010459)4.37778205
8Pancreatic cysts (HP:0001737)4.07549750
9Pancreatic fibrosis (HP:0100732)4.04647689
10Parakeratosis (HP:0001036)3.86858833
11Delayed epiphyseal ossification (HP:0002663)3.85852902
12Hypoplastic pelvis (HP:0008839)3.84766655
13Abnormality of midbrain morphology (HP:0002418)3.78657775
14Molar tooth sign on MRI (HP:0002419)3.78657775
15Sensory axonal neuropathy (HP:0003390)3.67228058
16Focal motor seizures (HP:0011153)3.59521467
17Abnormality of the corticospinal tract (HP:0002492)3.54576998
18Nephronophthisis (HP:0000090)3.49824702
19Vitreoretinal degeneration (HP:0000655)3.48905550
20Hyperventilation (HP:0002883)3.44237523
21Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.34769308
22Hemiparesis (HP:0001269)3.32868885
23Cerebral inclusion bodies (HP:0100314)3.28125039
24Progressive cerebellar ataxia (HP:0002073)3.27255628
25Peripheral hypomyelination (HP:0007182)3.26708875
26Hypoplastic ischia (HP:0003175)3.24186614
27Abnormality of the phalanges of the 2nd finger (HP:0009541)3.14527454
28Congenital stationary night blindness (HP:0007642)3.06889254
29Abnormal tarsal ossification (HP:0008369)3.05755363
30Abnormality of the renal medulla (HP:0100957)2.96987594
31Barrel-shaped chest (HP:0001552)2.95980466
32Increased serum pyruvate (HP:0003542)2.91934633
33Abnormality of glycolysis (HP:0004366)2.91934633
34Aplasia involving bones of the extremities (HP:0009825)2.88810250
35Aplasia involving bones of the upper limbs (HP:0009823)2.88810250
36Aplasia of the phalanges of the hand (HP:0009802)2.88810250
37Short femoral neck (HP:0100864)2.87597474
38Abnormality of the ischium (HP:0003174)2.85592061
39Type II lissencephaly (HP:0007260)2.84131323
40Cupped ribs (HP:0000887)2.83574662
41Absent epiphyses (HP:0010577)2.82386607
42Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.82386607
43Chronic hepatic failure (HP:0100626)2.79378322
44Relative macrocephaly (HP:0004482)2.78354850
45Focal seizures (HP:0007359)2.76752168
46Febrile seizures (HP:0002373)2.76712734
47Abolished electroretinogram (ERG) (HP:0000550)2.76681846
48Pendular nystagmus (HP:0012043)2.74984642
49Medial flaring of the eyebrow (HP:0010747)2.74857189
50Mixed hearing impairment (HP:0000410)2.70911203
51Abnormality of the vitreous humor (HP:0004327)2.70171949
52Cystic liver disease (HP:0006706)2.70025020
53Abnormality of the middle phalanges of the toes (HP:0010183)2.69372133
54Increased corneal curvature (HP:0100692)2.68178351
55Keratoconus (HP:0000563)2.68178351
56Genetic anticipation (HP:0003743)2.67968001
57Retinal dysplasia (HP:0007973)2.65379278
58Gaze-evoked nystagmus (HP:0000640)2.63839006
59Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.62609723
60Hemiplegia (HP:0002301)2.58698798
61Mild short stature (HP:0003502)2.57786460
62Genu varum (HP:0002970)2.56907765
63Abnormality of the vertebral endplates (HP:0005106)2.55221754
64Adrenal hypoplasia (HP:0000835)2.53388748
65Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.53144569
66Polydipsia (HP:0001959)2.52565190
67Abnormal drinking behavior (HP:0030082)2.52565190
68Abnormality of the renal cortex (HP:0011035)2.48755152
69Synostosis involving the elbow (HP:0003938)2.47227729
70Humeroradial synostosis (HP:0003041)2.47227729
71Sclerocornea (HP:0000647)2.47053289
72Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.46622357
73Irregular vertebral endplates (HP:0003301)2.45342239
74Tubular atrophy (HP:0000092)2.41828576
75Alacrima (HP:0000522)2.39561847
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.38123576
77Gait imbalance (HP:0002141)2.37708692
78Flat capital femoral epiphysis (HP:0003370)2.36115645
79Atonic seizures (HP:0010819)2.36053324
80Attenuation of retinal blood vessels (HP:0007843)2.33514393
81Supranuclear gaze palsy (HP:0000605)2.32792998
82Oligodactyly (hands) (HP:0001180)2.26026418
83Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.24890934
84Abnormality of femoral epiphyses (HP:0006499)2.24890934
85Chorioretinal atrophy (HP:0000533)2.24506178
86Abnormality of incisor morphology (HP:0011063)2.23397809
87Dialeptic seizures (HP:0011146)2.22975264
88Broad-based gait (HP:0002136)2.22810105
89Absent/shortened dynein arms (HP:0200106)2.22691157
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.22691157
91Aplasia/Hypoplasia of the tibia (HP:0005772)2.21530657
92Neonatal short-limb short stature (HP:0008921)2.20604507
93Leukodystrophy (HP:0002415)2.20556784
94Stenosis of the external auditory canal (HP:0000402)2.20531061
95Spastic gait (HP:0002064)2.19965754
96Metaphyseal irregularity (HP:0003025)2.17844711
97Metaphyseal dysplasia (HP:0100255)2.17757372
98Enlarged epiphyses (HP:0010580)2.17666918
99Anencephaly (HP:0002323)2.17481367
100Aplasia/Hypoplasia of the tongue (HP:0010295)2.16212334
101Action tremor (HP:0002345)2.14766992
102Epileptic encephalopathy (HP:0200134)2.14293513
103Intention tremor (HP:0002080)2.13666311
104Congenital primary aphakia (HP:0007707)2.13653601
105Optic nerve hypoplasia (HP:0000609)2.13462600
106Premature skin wrinkling (HP:0100678)2.12161376
107Abnormality of the femoral head (HP:0003368)2.09656806
108Anomalous pulmonary venous return (HP:0010772)2.09550059
109Increased circulating renin level (HP:0000848)2.09538935
110Aplasia/hypoplasia of the femur (HP:0005613)2.08681773
111Abnormality of the epiphysis of the femoral head (HP:0010574)2.08670223
112Decreased central vision (HP:0007663)2.08048018
113Congenital ichthyosiform erythroderma (HP:0007431)2.06939095
114Congenital hepatic fibrosis (HP:0002612)2.06669211
115Abnormality of carpal bone ossification (HP:0006257)2.06546378
116Onion bulb formation (HP:0003383)2.06537372
117Split foot (HP:0001839)2.06515906
118Dysmetria (HP:0001310)2.05064213
119Septo-optic dysplasia (HP:0100842)2.04655387
120Congenital sensorineural hearing impairment (HP:0008527)2.04525576
121Large for gestational age (HP:0001520)2.03414633
122Nephrogenic diabetes insipidus (HP:0009806)2.02918790
123Inability to walk (HP:0002540)2.02432774
124Furrowed tongue (HP:0000221)2.02178878
125Cupped ear (HP:0000378)2.02039650
126Abnormal ciliary motility (HP:0012262)2.01467195
127Partial agenesis of the corpus callosum (HP:0001338)2.00968266
128Osteoarthritis (HP:0002758)2.00572535
129Anteriorly placed anus (HP:0001545)1.99771256
130Abnormal auditory evoked potentials (HP:0006958)1.99601105
131Male pseudohermaphroditism (HP:0000037)1.98375764
132Progressive macrocephaly (HP:0004481)1.98373672
133Gastrointestinal atresia (HP:0002589)1.98239800
134Absence seizures (HP:0002121)1.97595718
135Hypoplastic left heart (HP:0004383)1.97593981
136Insidious onset (HP:0003587)1.97473828
137Termporal pattern (HP:0011008)1.97473828
138Abnormal respiratory epithelium morphology (HP:0012253)1.97303587
139Abnormal respiratory motile cilium morphology (HP:0005938)1.97303587
140Akinesia (HP:0002304)1.97111344
141Lissencephaly (HP:0001339)1.96542673
142Absent speech (HP:0001344)1.96433742
143Intestinal atresia (HP:0011100)1.95119701
144Vertebral clefting (HP:0008428)1.94150069
145Postaxial foot polydactyly (HP:0001830)1.93861405
146Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.93671668
147Short 1st metacarpal (HP:0010034)1.93671668
148Scanning speech (HP:0002168)1.93484209
149Morphological abnormality of the inner ear (HP:0011390)1.91663981
150Flattened epiphyses (HP:0003071)1.91045085
151Short hallux (HP:0010109)1.91034401
152Abnormality of the 2nd finger (HP:0004100)1.90558463
153Renal Fanconi syndrome (HP:0001994)1.90512169
154Protuberant abdomen (HP:0001538)1.89641838
155Clumsiness (HP:0002312)1.88739125
156Spastic paraparesis (HP:0002313)1.88581543
157Bony spicule pigmentary retinopathy (HP:0007737)1.88269937
158Genital tract atresia (HP:0001827)1.88033781
159Arthropathy (HP:0003040)1.88026201
160Aplasia/Hypoplasia of the hallux (HP:0008362)1.87861351
161Congenital, generalized hypertrichosis (HP:0004540)1.87390967
162Decreased lacrimation (HP:0000633)1.86177639
163Flat acetabular roof (HP:0003180)1.85587420
164Cerebral hypomyelination (HP:0006808)1.84790106
165Ectopic kidney (HP:0000086)1.84786412
166Coronal craniosynostosis (HP:0004440)1.84582594
167Polyuria (HP:0000103)1.83141143
168Status epilepticus (HP:0002133)1.83135713
169Slow saccadic eye movements (HP:0000514)1.83128778
170Myokymia (HP:0002411)1.83058701
171Anophthalmia (HP:0000528)1.83052815
172Preaxial hand polydactyly (HP:0001177)1.83020242
173Megalencephaly (HP:0001355)1.82969269
174Severe muscular hypotonia (HP:0006829)1.82722691
175Generalized tonic-clonic seizures (HP:0002069)1.82312869
176Abnormality of the proximal phalanges of the hand (HP:0009834)1.82044886
177Absent septum pellucidum (HP:0001331)1.81518870
178Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80893217
179Abnormality of the pulmonary veins (HP:0011718)1.80884149
180Acute necrotizing encephalopathy (HP:0006965)1.79994661
181Diplopia (HP:0000651)1.79955732
182Abnormality of binocular vision (HP:0011514)1.79955732
183Patchy hypopigmentation of hair (HP:0011365)1.79773931
184Cerebellar dysplasia (HP:0007033)1.79147040
185Postaxial hand polydactyly (HP:0001162)1.78297370
186Vaginal atresia (HP:0000148)1.78004876
187Autoamputation (HP:0001218)1.77638425
188Progressive inability to walk (HP:0002505)1.76652237
189Occipital encephalocele (HP:0002085)1.76556731
190Hypomagnesemia (HP:0002917)1.76424581
191Esophageal atresia (HP:0002032)1.73740107
192Short tibia (HP:0005736)1.72967200
193Neoplasm of the oral cavity (HP:0100649)1.71466348
194Short phalanx of the thumb (HP:0009660)1.70675144
195Tachypnea (HP:0002789)1.67618283
196Abnormal rod and cone electroretinograms (HP:0008323)1.67045614
197Specific learning disability (HP:0001328)1.66300281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.71871805
2FRK4.74288624
3TNIK4.54263586
4EPHB13.85448923
5OXSR13.76085691
6PBK3.05650537
7PINK12.63833527
8GRK12.47101279
9WNK42.44369212
10MST42.43994389
11CASK2.36982910
12NTRK32.24477196
13PKN12.20931831
14TYRO32.19879674
15MAPKAPK52.19357552
16BCR2.13460711
17MUSK1.96164164
18EPHA41.94759596
19NEK61.88109506
20MAP4K21.81309446
21FGR1.70139715
22UHMK11.69727043
23FES1.64691988
24ACVR1B1.63667028
25ZAK1.60771943
26CDK191.59930748
27NUAK11.58220105
28TAOK31.50059734
29MET1.49546344
30DAPK21.43804445
31WEE11.43009203
32DDR21.42556233
33MAPK131.41262345
34TLK11.40769696
35WNK11.32795457
36INSRR1.32458759
37ROCK21.31688544
38ICK1.28529443
39NTRK11.22908033
40IRAK21.19818531
41PHKG11.18635676
42PHKG21.18635676
43PNCK1.17963679
44LIMK11.15170314
45CSNK1G31.14081430
46VRK11.10418376
47CSNK1A1L1.09930483
48PRKCQ1.09657507
49MAP2K71.08022525
50FGFR21.07520994
51NTRK21.07252017
52TSSK61.03862876
53MKNK10.99642627
54IRAK10.99372387
55CSNK1G10.94097715
56CAMK2B0.94025147
57PAK60.91911056
58MARK10.91185169
59PAK30.91104281
60SGK2230.90902723
61SGK4940.90902723
62CAMK2D0.90490005
63CSNK1G20.88728567
64STK38L0.85714846
65ERBB40.84728382
66CLK10.84067922
67CAMK2A0.83078979
68CAMKK20.82708814
69PDGFRB0.78639711
70DYRK20.77479556
71PRKCE0.75180322
72EPHA30.74335727
73CDK50.73090078
74PRPF4B0.72136116
75ROCK10.71182435
76NME10.70009995
77TIE10.69057793
78MINK10.67952058
79SGK20.67509362
80MAPKAPK30.66584389
81BRSK20.66051569
82CSK0.65676252
83FYN0.65298938
84ERBB30.65056369
85TNK20.63132122
86CDK30.62396858
87GRK50.62165624
88TESK20.61431046
89PLK20.60186320
90IRAK40.59347973
91CDK140.58734107
92ADRBK20.57634216
93ERBB20.56789918
94MAPK70.56762091
95TGFBR10.56753281
96PRKG10.55905193
97TXK0.55082365
98CAMK2G0.54897789
99CAMK10.54284520
100GSK3A0.53511000
101MAPK120.53500265
102PDPK10.53373577
103PLK30.53016245
104PRKD10.52847674
105PRKD30.51746120
106MARK20.51545464
107MAPK150.50792040
108TRIM280.50774171
109DYRK1A0.50594166
110MKNK20.49814842
111BMPR1B0.49406727
112PIK3CA0.49248966
113CDK150.47425220
114PRKACA0.46608728
115BCKDK0.45100800
116STK110.44181812
117CSNK1D0.43232856
118CDK180.43042561
119CDK11A0.42952826
120CCNB10.41959488
121CSNK1A10.40893871
122INSR0.40592246
123MAP2K40.39612026
124STK240.39491864
125PRKCZ0.38299446
126NLK0.35665253
127SGK10.35586527
128PRKACB0.34812723
129SIK20.34213254
130PRKD20.34183777
131MAP2K10.33436852
132WNK30.33414404
133RPS6KA50.32136346
134PRKCH0.31743699
135ADRBK10.29915391
136CAMKK10.29835445
137YES10.29507887
138OBSCN0.29189924
139GRK70.28866085
140MAP3K40.28676559
141PRKCA0.27949265
142PRKG20.27884978
143BMPR20.27165437
144PTK2B0.26350500
145PRKCG0.26305209
146LCK0.25711609

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.00677388
2Steroid biosynthesis_Homo sapiens_hsa001005.44185135
3Fatty acid elongation_Homo sapiens_hsa000624.12275003
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.91506773
5Ether lipid metabolism_Homo sapiens_hsa005652.97482460
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66524716
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15375619
8Sphingolipid metabolism_Homo sapiens_hsa006002.09057473
9Oxidative phosphorylation_Homo sapiens_hsa001902.03238883
10Sulfur metabolism_Homo sapiens_hsa009201.99207379
11Insulin secretion_Homo sapiens_hsa049111.88285902
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.81511425
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.76142003
14Taste transduction_Homo sapiens_hsa047421.69185118
15Protein export_Homo sapiens_hsa030601.62286504
16Butanoate metabolism_Homo sapiens_hsa006501.59604175
17Nitrogen metabolism_Homo sapiens_hsa009101.59115018
18Axon guidance_Homo sapiens_hsa043601.56888591
19Glutamatergic synapse_Homo sapiens_hsa047241.51526385
20Olfactory transduction_Homo sapiens_hsa047401.51242637
21Fatty acid metabolism_Homo sapiens_hsa012121.50794519
22Tryptophan metabolism_Homo sapiens_hsa003801.48469621
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45173523
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39658452
25Amphetamine addiction_Homo sapiens_hsa050311.39224016
26Fatty acid biosynthesis_Homo sapiens_hsa000611.36914419
27Alzheimers disease_Homo sapiens_hsa050101.33842951
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.31095940
29Parkinsons disease_Homo sapiens_hsa050121.29422705
30Serotonergic synapse_Homo sapiens_hsa047261.26898509
31Fanconi anemia pathway_Homo sapiens_hsa034601.22903377
32GABAergic synapse_Homo sapiens_hsa047271.22357885
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20761805
34Long-term depression_Homo sapiens_hsa047301.20635381
35Selenocompound metabolism_Homo sapiens_hsa004501.17171418
36Linoleic acid metabolism_Homo sapiens_hsa005911.16100914
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12995273
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10595231
39ECM-receptor interaction_Homo sapiens_hsa045121.09789733
40Vitamin B6 metabolism_Homo sapiens_hsa007501.07762212
41Homologous recombination_Homo sapiens_hsa034401.02520332
42beta-Alanine metabolism_Homo sapiens_hsa004100.99210847
43cAMP signaling pathway_Homo sapiens_hsa040240.98857726
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98285488
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97088217
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95013863
47Histidine metabolism_Homo sapiens_hsa003400.91882404
48Propanoate metabolism_Homo sapiens_hsa006400.90104210
49RNA polymerase_Homo sapiens_hsa030200.89612791
50Synaptic vesicle cycle_Homo sapiens_hsa047210.88790208
51Salivary secretion_Homo sapiens_hsa049700.87640199
52Arginine and proline metabolism_Homo sapiens_hsa003300.86925961
53ABC transporters_Homo sapiens_hsa020100.86874278
54Basal transcription factors_Homo sapiens_hsa030220.86862471
55Caffeine metabolism_Homo sapiens_hsa002320.86696029
56Nicotine addiction_Homo sapiens_hsa050330.85641570
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85178162
58Morphine addiction_Homo sapiens_hsa050320.84738118
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83611682
60Regulation of autophagy_Homo sapiens_hsa041400.82834155
61Oxytocin signaling pathway_Homo sapiens_hsa049210.79668996
62Renal cell carcinoma_Homo sapiens_hsa052110.77290476
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.76424628
64Collecting duct acid secretion_Homo sapiens_hsa049660.74649031
65Cholinergic synapse_Homo sapiens_hsa047250.74042154
66Glycerolipid metabolism_Homo sapiens_hsa005610.72158050
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71925866
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71037697
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69445058
70Huntingtons disease_Homo sapiens_hsa050160.68816563
71Glutathione metabolism_Homo sapiens_hsa004800.68417844
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67949165
73Circadian entrainment_Homo sapiens_hsa047130.67905705
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67736470
75Cardiac muscle contraction_Homo sapiens_hsa042600.67648874
76Dorso-ventral axis formation_Homo sapiens_hsa043200.67537056
77Arachidonic acid metabolism_Homo sapiens_hsa005900.67510117
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66819611
79Ovarian steroidogenesis_Homo sapiens_hsa049130.65818936
80RNA degradation_Homo sapiens_hsa030180.65259735
81Peroxisome_Homo sapiens_hsa041460.64508782
82Protein digestion and absorption_Homo sapiens_hsa049740.64416665
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63970777
84Tight junction_Homo sapiens_hsa045300.63199116
85Gastric acid secretion_Homo sapiens_hsa049710.62830142
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.62195303
87Rheumatoid arthritis_Homo sapiens_hsa053230.59056040
88Circadian rhythm_Homo sapiens_hsa047100.58927348
89Vibrio cholerae infection_Homo sapiens_hsa051100.58463825
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57648302
91One carbon pool by folate_Homo sapiens_hsa006700.56961696
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53186144
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52119945
94Fatty acid degradation_Homo sapiens_hsa000710.51438994
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.51235740
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51010939
97Dopaminergic synapse_Homo sapiens_hsa047280.50700510
98Cocaine addiction_Homo sapiens_hsa050300.50078396
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49776401
100Gap junction_Homo sapiens_hsa045400.49279343
101Ras signaling pathway_Homo sapiens_hsa040140.48747605
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.48024124
103Pancreatic secretion_Homo sapiens_hsa049720.46741085
104Choline metabolism in cancer_Homo sapiens_hsa052310.46447071
105Hippo signaling pathway_Homo sapiens_hsa043900.46366816
106Mineral absorption_Homo sapiens_hsa049780.46011932
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.45883924
108Hedgehog signaling pathway_Homo sapiens_hsa043400.45508549
109Bile secretion_Homo sapiens_hsa049760.45090548
110Malaria_Homo sapiens_hsa051440.44910265
111Renin secretion_Homo sapiens_hsa049240.43805425
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43800721
113Metabolic pathways_Homo sapiens_hsa011000.43107446
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41372768
115Folate biosynthesis_Homo sapiens_hsa007900.41071846
116Thyroid hormone synthesis_Homo sapiens_hsa049180.40413117
117Other glycan degradation_Homo sapiens_hsa005110.39038720
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37294358
119Sulfur relay system_Homo sapiens_hsa041220.35419470
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33154957
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32847244
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32262671
123Vitamin digestion and absorption_Homo sapiens_hsa049770.31486216
124Phototransduction_Homo sapiens_hsa047440.29551744
125Phagosome_Homo sapiens_hsa041450.29495613
126Retinol metabolism_Homo sapiens_hsa008300.29106346
127Pyruvate metabolism_Homo sapiens_hsa006200.28767386
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28259601
129Calcium signaling pathway_Homo sapiens_hsa040200.28166910
130PPAR signaling pathway_Homo sapiens_hsa033200.27156260
131Basal cell carcinoma_Homo sapiens_hsa052170.26352704
132Chemical carcinogenesis_Homo sapiens_hsa052040.25725680
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25135527
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24745448

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