SCRIB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.42147119
2embryonic process involved in female pregnancy (GO:0060136)6.46616700
3transcription from mitochondrial promoter (GO:0006390)6.24299901
4proline metabolic process (GO:0006560)6.07030948
5replication fork processing (GO:0031297)5.57393265
6regulation of integrin activation (GO:0033623)5.41769831
7positive regulation of protein homooligomerization (GO:0032464)5.20228064
8regulation of translational fidelity (GO:0006450)5.02693671
9mitotic G1 DNA damage checkpoint (GO:0031571)4.99508047
10planar cell polarity pathway involved in neural tube closure (GO:0090179)4.90908528
11desmosome organization (GO:0002934)4.84052408
12maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.78072930
13regulation of protein homooligomerization (GO:0032462)4.67614986
14mitochondrial DNA metabolic process (GO:0032042)4.60608801
15oxidative demethylation (GO:0070989)4.60503272
16spliceosomal tri-snRNP complex assembly (GO:0000244)4.47355610
17somatic diversification of immune receptors via somatic mutation (GO:0002566)4.44873249
18somatic hypermutation of immunoglobulin genes (GO:0016446)4.44873249
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.43347740
20mitotic G1/S transition checkpoint (GO:0044819)4.42133499
21G1 DNA damage checkpoint (GO:0044783)4.36716276
22hemidesmosome assembly (GO:0031581)4.34599471
23DNA strand renaturation (GO:0000733)4.32323570
24semaphorin-plexin signaling pathway (GO:0071526)4.31917318
25negative regulation of cell size (GO:0045792)4.28933023
26negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.28050665
27adherens junction assembly (GO:0034333)4.27506832
28regulation of RNA export from nucleus (GO:0046831)4.26725177
29embryonic placenta development (GO:0001892)4.24762916
30poly(A)+ mRNA export from nucleus (GO:0016973)4.23229469
31mRNA cleavage (GO:0006379)4.16759613
32cell-substrate adherens junction assembly (GO:0007045)4.14804101
33focal adhesion assembly (GO:0048041)4.14804101
34COPI coating of Golgi vesicle (GO:0048205)4.09917638
35Golgi transport vesicle coating (GO:0048200)4.09917638
36regulation of hippo signaling (GO:0035330)4.06424686
37dosage compensation (GO:0007549)4.05446188
38DNA deamination (GO:0045006)4.00677389
39pre-miRNA processing (GO:0031054)3.99441648
40cytoskeletal anchoring at plasma membrane (GO:0007016)3.97754064
41cell-substrate junction assembly (GO:0007044)3.94491419
42regulation of posttranscriptional gene silencing (GO:0060147)3.92396661
43regulation of gene silencing by miRNA (GO:0060964)3.92396661
44regulation of gene silencing by RNA (GO:0060966)3.92396661
45regulation of sister chromatid cohesion (GO:0007063)3.91632389
46histone H4-K12 acetylation (GO:0043983)3.89538748
47protein retention in ER lumen (GO:0006621)3.86816426
48regulation of mammary gland epithelial cell proliferation (GO:0033599)3.85643431
49negative regulation of JAK-STAT cascade (GO:0046426)3.82518761
50anatomical structure regression (GO:0060033)3.80390178
51positive regulation of mitotic sister chromatid separation (GO:1901970)3.78662790
52positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.78662790
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.78662790
54embryonic camera-type eye development (GO:0031076)3.77570321
55negative regulation of mRNA processing (GO:0050686)3.77479647
56trophectodermal cell differentiation (GO:0001829)3.74291538
57negative regulation of cell cycle arrest (GO:0071157)3.73714378
58epithelial cell-cell adhesion (GO:0090136)3.68897357
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.68845042
60convergent extension (GO:0060026)3.63853251
61base-excision repair (GO:0006284)3.62835824
62negative regulation of Ras GTPase activity (GO:0034261)3.56068390
63maternal placenta development (GO:0001893)3.54603022
64regulation of glucose import in response to insulin stimulus (GO:2001273)3.53230688
65intracellular estrogen receptor signaling pathway (GO:0030520)3.51234251
66heterochromatin organization (GO:0070828)3.49124205
67formation of translation preinitiation complex (GO:0001731)3.47055243
68positive regulation by host of viral transcription (GO:0043923)3.46409796
69retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.43585103
70negative regulation of protein oligomerization (GO:0032460)3.42904065
71viral mRNA export from host cell nucleus (GO:0046784)3.41358487
72regulation of nucleobase-containing compound transport (GO:0032239)3.39308131
73atrioventricular valve morphogenesis (GO:0003181)3.39084004
74regulation of early endosome to late endosome transport (GO:2000641)3.38595054
75negative regulation of fatty acid biosynthetic process (GO:0045717)3.35506998
76DNA unwinding involved in DNA replication (GO:0006268)3.35094206
77basement membrane organization (GO:0071711)3.33443408
78negative regulation of RNA splicing (GO:0033119)3.31450046
79positive regulation of protein oligomerization (GO:0032461)3.31237596
80* apoptotic process involved in morphogenesis (GO:0060561)3.29604211
81DNA topological change (GO:0006265)3.29484861
82protein localization to endosome (GO:0036010)3.28568926
83negative regulation of mRNA metabolic process (GO:1903312)3.27644506
84face development (GO:0060324)3.27135755
85regulation of DNA damage checkpoint (GO:2000001)3.27134058
86glutamine family amino acid biosynthetic process (GO:0009084)3.27014846
87nodal signaling pathway (GO:0038092)3.20561117
88cellular response to ATP (GO:0071318)3.19593638
89positive regulation of chromosome segregation (GO:0051984)3.19218141
90termination of RNA polymerase II transcription (GO:0006369)3.18238871
91Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.18010412
92cell-cell junction maintenance (GO:0045217)3.16865522
93meiotic chromosome segregation (GO:0045132)3.16542954
94regulation of protein oligomerization (GO:0032459)3.16462891
95negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.16381757
96regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.13172150
97labyrinthine layer development (GO:0060711)3.13135404
98mitotic sister chromatid segregation (GO:0000070)3.12445804
99regulation of NFAT protein import into nucleus (GO:0051532)3.11584874
100negative regulation of fatty acid transport (GO:2000192)3.09160942
101determination of adult lifespan (GO:0008340)3.04045407
102regulation of protein polyubiquitination (GO:1902914)3.02438802
103mitotic chromosome condensation (GO:0007076)3.01693014
104regulation of double-strand break repair (GO:2000779)3.01093135
105dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.98250199
106regulation of establishment of planar polarity (GO:0090175)2.96577677
107non-recombinational repair (GO:0000726)2.96213086
108double-strand break repair via nonhomologous end joining (GO:0006303)2.96213086
109branching involved in mammary gland duct morphogenesis (GO:0060444)2.95858226
110hypotonic response (GO:0006971)2.95300766
111endothelial cell chemotaxis (GO:0035767)2.94570394
112regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.94304818
113positive regulation of Cdc42 GTPase activity (GO:0043089)2.93895888
114telomere maintenance via semi-conservative replication (GO:0032201)2.93792350
115epithelial cell differentiation involved in prostate gland development (GO:0060742)2.91378926
116mannose metabolic process (GO:0006013)2.90536328
117cellular response to zinc ion (GO:0071294)2.89582745
118regulation of fatty acid beta-oxidation (GO:0031998)2.88606111
119negative regulation of erythrocyte differentiation (GO:0045647)2.85992358
120sister chromatid segregation (GO:0000819)2.85612366
121regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.85382610
122negative regulation of glial cell proliferation (GO:0060253)2.84361153
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.83743616
124DNA integration (GO:0015074)2.83308978
125polarized epithelial cell differentiation (GO:0030859)2.83257031
126neural tube development (GO:0021915)2.82499349
127insulin-like growth factor receptor signaling pathway (GO:0048009)2.81824790
128regulation of cell size (GO:0008361)2.81684914
129regulation of cholesterol biosynthetic process (GO:0045540)2.78739342
130signal complex assembly (GO:0007172)2.77969186
131embryonic eye morphogenesis (GO:0048048)2.77695353
132mitochondrial RNA metabolic process (GO:0000959)2.75565268
133mRNA transport (GO:0051028)2.74762198
134* activation of Rac GTPase activity (GO:0032863)2.74094394
135mRNA export from nucleus (GO:0006406)2.73235526
136retinoic acid receptor signaling pathway (GO:0048384)2.72581365
137cellular response to epidermal growth factor stimulus (GO:0071364)2.72546710
138positive regulation of developmental pigmentation (GO:0048087)2.70868259
139regulation of water loss via skin (GO:0033561)2.70077503
140negative regulation of chondrocyte differentiation (GO:0032331)2.69824992
141anterior/posterior axis specification, embryo (GO:0008595)2.69469576
142regulation of podosome assembly (GO:0071801)2.67412324
143resolution of meiotic recombination intermediates (GO:0000712)2.67347781
144regulation of chromatin binding (GO:0035561)2.66002482
145negative regulation of viral release from host cell (GO:1902187)2.65512246
146histone H4-K5 acetylation (GO:0043981)2.64535806
147histone H4-K8 acetylation (GO:0043982)2.64535806
148positive regulation of histone deacetylation (GO:0031065)2.64457263
149ear development (GO:0043583)2.63689423
150cochlea morphogenesis (GO:0090103)2.62428415
151peptidyl-lysine dimethylation (GO:0018027)2.61309128
152cellular protein complex localization (GO:0034629)2.60755288
153nucleosome disassembly (GO:0006337)2.60125736
154protein-DNA complex disassembly (GO:0032986)2.60125736
155positive regulation of blood vessel endothelial cell migration (GO:0043536)2.60036533
156peptidyl-arginine omega-N-methylation (GO:0035247)2.59877011
157positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.57496310
158branching involved in salivary gland morphogenesis (GO:0060445)2.55906255
159glucose catabolic process (GO:0006007)2.53702511
160regulation of endothelial cell chemotaxis (GO:2001026)2.52237886
161activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52061258
162vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.51649158
163activation of MAPKKK activity (GO:0000185)2.49535909
164eye morphogenesis (GO:0048592)2.48068225
165protein complex localization (GO:0031503)2.47582326
166peptidyl-tyrosine autophosphorylation (GO:0038083)2.46523914
167protein localization to microtubule (GO:0035372)2.46307968
168negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.45408807
169glucose 6-phosphate metabolic process (GO:0051156)2.44891367
170positive regulation of nuclease activity (GO:0032075)2.43856524
171RNA stabilization (GO:0043489)2.43212428
172mRNA stabilization (GO:0048255)2.43212428
173positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.42972114
174trophoblast giant cell differentiation (GO:0060707)2.42046940
175negative regulation of cell fate specification (GO:0009996)2.41438471
176snRNA metabolic process (GO:0016073)2.40257218
177pentose-phosphate shunt (GO:0006098)2.39326425
178regulation of histone H3-K27 methylation (GO:0061085)2.38545144
179actin filament bundle assembly (GO:0051017)2.34701972
180actin filament bundle organization (GO:0061572)2.34701972
181adherens junction organization (GO:0034332)2.33759871
182stress fiber assembly (GO:0043149)2.33362307
183regulation of ARF GTPase activity (GO:0032312)2.32417683
184positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.32032605
185regulation of extracellular matrix disassembly (GO:0010715)2.31377746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.17398185
2SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.09154889
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.98283721
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93442633
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.92779224
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.78007266
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.78007266
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.78007266
9VDR_21846776_ChIP-Seq_THP-1_Human2.58202716
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53519671
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.53378675
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.47695078
13MYC_22102868_ChIP-Seq_BL_Human2.46820710
14* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.07768606
15* LXR_22292898_ChIP-Seq_THP-1_Human2.05925096
16KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.04058309
17* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03732773
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02316425
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.02169467
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99889755
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98356152
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98059398
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.97130558
24POU5F1_16518401_ChIP-PET_MESCs_Mouse1.95056755
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89952195
26* MYC_18555785_ChIP-Seq_MESCs_Mouse1.88631841
27KDM2B_26808549_Chip-Seq_DND41_Human1.88019721
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85165550
29ZNF263_19887448_ChIP-Seq_K562_Human1.84946162
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84806640
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80210817
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79630646
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79096089
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77550416
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77448255
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76577541
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76055391
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75815940
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.75548787
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73987840
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.72338661
42TCF3_18692474_ChIP-Seq_MESCs_Mouse1.72267757
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71539679
44RACK7_27058665_Chip-Seq_MCF-7_Human1.69167687
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69038791
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67980835
47NANOG_21062744_ChIP-ChIP_HESCs_Human1.65305668
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62211502
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60503546
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58802116
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.56867882
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56800947
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.55716702
54* TCF7_22412390_ChIP-Seq_EML_Mouse1.55011121
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52575200
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.52095846
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.52062450
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52047425
59NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.50696612
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50349370
61* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47933157
62SMC4_20622854_ChIP-Seq_HELA_Human1.47788226
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.44185931
64CLOCK_20551151_ChIP-Seq_293T_Human1.39011942
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.37913256
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36462990
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35495182
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34482481
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34164154
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32365788
71* TP53_22127205_ChIP-Seq_IMR90_Human1.32164477
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32084514
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31165914
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28938179
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28832000
76SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27924469
77KDM2B_26808549_Chip-Seq_K562_Human1.27585301
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27175800
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24970045
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24525358
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.24408309
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24143425
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23501985
84* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22620283
85* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21300586
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20402976
87SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19535945
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.18255816
89* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17562044
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17445955
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16382529
92* CTCF_27219007_Chip-Seq_Bcells_Human1.15616956
93CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14780432
94P68_20966046_ChIP-Seq_HELA_Human1.13437445
95* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13140778
96E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13081802
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12032730
98PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11682087
99KDM5A_27292631_Chip-Seq_BREAST_Human1.11359367
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.11356874
101NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10935338
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10748735
103CREB1_26743006_Chip-Seq_LNCaP_Human1.10158639
104* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09688860
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09640805
106PHF8_20622854_ChIP-Seq_HELA_Human1.09130730
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09000230
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08963886
109ATF3_27146783_Chip-Seq_COLON_Human1.08814085
110ETS1_21867929_ChIP-Seq_TH2_Mouse1.07900405
111BCOR_27268052_Chip-Seq_Bcells_Human1.07458907
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06201750
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06051455
114NCOR1_26117541_ChIP-Seq_K562_Human1.05938516
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05558466
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05339353
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04959162
118SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04238610
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04181896
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02878772
121MAF_26560356_Chip-Seq_TH1_Human1.02828875
122UTX_26944678_Chip-Seq_JUKART_Human1.02439641
123EGR1_19374776_ChIP-ChIP_THP-1_Human1.02395799
124TET1_21490601_ChIP-Seq_MESCs_Mouse1.01888306
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01852501
126VDR_24763502_ChIP-Seq_THP-1_Human1.01296982
127E2F1_21310950_ChIP-Seq_MCF-7_Human1.01259195
128RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01199446
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00787150
130TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00776178
131* RARB_24833708_ChIP-Seq_LIVER_Mouse0.99596651
132E2F1_20622854_ChIP-Seq_HELA_Human0.99556347
133ELF1_20517297_ChIP-Seq_JURKAT_Human0.99429177
134SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99414014
135SA1_27219007_Chip-Seq_ERYTHROID_Human0.99157908
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96992650
137TP63_22573176_ChIP-Seq_HFKS_Human0.96569029
138P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96033351
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.95861277
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94158678
141XRN2_22483619_ChIP-Seq_HELA_Human0.93622276
142TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92484657
143TRIM28_21343339_ChIP-Seq_HEK293_Human0.91075730
144MAF_26560356_Chip-Seq_TH2_Human0.89640086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.94884867
2MP0009278_abnormal_bone_marrow4.44084888
3MP0010234_abnormal_vibrissa_follicle4.01240694
4MP0010030_abnormal_orbit_morphology3.40038379
5MP0004233_abnormal_muscle_weight3.22551423
6MP0005076_abnormal_cell_differentiation2.73221362
7MP0005171_absent_coat_pigmentation2.68636694
8MP0008995_early_reproductive_senescence2.59709904
9MP0003283_abnormal_digestive_organ2.57275949
10MP0000566_synostosis2.57059192
11MP0002877_abnormal_melanocyte_morpholog2.50796898
12MP0002653_abnormal_ependyma_morphology2.50361269
13MP0010352_gastrointestinal_tract_polyps2.41729488
14MP0010094_abnormal_chromosome_stability2.40195816
15MP0004858_abnormal_nervous_system2.37007539
16MP0005451_abnormal_body_composition2.25048896
17MP0008877_abnormal_DNA_methylation2.22607158
18MP0002009_preneoplasia2.19786848
19MP0003705_abnormal_hypodermis_morpholog2.19764422
20MP0005409_darkened_coat_color2.18394662
21MP0003890_abnormal_embryonic-extraembry2.14370876
22MP0003119_abnormal_digestive_system2.03474325
23MP0003111_abnormal_nucleus_morphology2.01387883
24MP0001545_abnormal_hematopoietic_system1.97603383
25MP0005397_hematopoietic_system_phenotyp1.97603383
26MP0000678_abnormal_parathyroid_gland1.93649917
27MP0004957_abnormal_blastocyst_morpholog1.92081928
28MP0008438_abnormal_cutaneous_collagen1.83987297
29MP0005257_abnormal_intraocular_pressure1.80436409
30MP0002086_abnormal_extraembryonic_tissu1.80079030
31* MP0002084_abnormal_developmental_patter1.79054000
32MP0002089_abnormal_postnatal_growth/wei1.77549345
33MP0003786_premature_aging1.77028443
34MP0001348_abnormal_lacrimal_gland1.76832498
35MP0005058_abnormal_lysosome_morphology1.74035043
36MP0000751_myopathy1.73539873
37MP0003453_abnormal_keratinocyte_physiol1.72395120
38* MP0004197_abnormal_fetal_growth/weight/1.68490022
39* MP0002085_abnormal_embryonic_tissue1.66265590
40MP0002249_abnormal_larynx_morphology1.63358699
41MP0004133_heterotaxia1.63047457
42MP0001293_anophthalmia1.62826384
43MP0000003_abnormal_adipose_tissue1.57953534
44* MP0001697_abnormal_embryo_size1.57837373
45MP0002282_abnormal_trachea_morphology1.56213123
46MP0001730_embryonic_growth_arrest1.55833350
47MP0005380_embryogenesis_phenotype1.54918375
48MP0001672_abnormal_embryogenesis/_devel1.54918375
49MP0004272_abnormal_basement_membrane1.54034141
50MP0002098_abnormal_vibrissa_morphology1.52463176
51MP0003091_abnormal_cell_migration1.50205371
52MP0008260_abnormal_autophagy1.49925497
53MP0003077_abnormal_cell_cycle1.49035513
54MP0005666_abnormal_adipose_tissue1.44588008
55MP0000350_abnormal_cell_proliferation1.41139282
56MP0010307_abnormal_tumor_latency1.40216767
57MP0002796_impaired_skin_barrier1.38556931
58MP0005174_abnormal_tail_pigmentation1.37577049
59MP0005375_adipose_tissue_phenotype1.35739641
60MP0000579_abnormal_nail_morphology1.31605771
61MP0003984_embryonic_growth_retardation1.30638246
62MP0002269_muscular_atrophy1.29951863
63MP0003567_abnormal_fetal_cardiomyocyte1.29925477
64MP0001216_abnormal_epidermal_layer1.28833010
65MP0008058_abnormal_DNA_repair1.28774234
66MP0002088_abnormal_embryonic_growth/wei1.27017651
67MP0003045_fibrosis1.25001489
68MP0008932_abnormal_embryonic_tissue1.24881133
69MP0009672_abnormal_birth_weight1.23762294
70MP0006072_abnormal_retinal_apoptosis1.22949834
71MP0004381_abnormal_hair_follicle1.22584707
72MP0002080_prenatal_lethality1.21077751
73MP0000371_diluted_coat_color1.20693669
74MP0003566_abnormal_cell_adhesion1.17720357
75MP0000490_abnormal_crypts_of1.15797825
76MP0000377_abnormal_hair_follicle1.15561292
77MP0000462_abnormal_digestive_system1.11114751
78MP0003935_abnormal_craniofacial_develop1.10832089
79MP0009053_abnormal_anal_canal1.10804252
80MP0003123_paternal_imprinting1.09457500
81MP0005623_abnormal_meninges_morphology1.07510593
82MP0001145_abnormal_male_reproductive1.05493924
83MP0000534_abnormal_ureter_morphology1.05329272
84MP0002932_abnormal_joint_morphology1.05091755
85MP0004264_abnormal_extraembryonic_tissu1.04674374
86MP0005501_abnormal_skin_physiology1.03582350
87MP0010771_integument_phenotype1.03226993
88MP0001849_ear_inflammation1.02968895
89MP0005410_abnormal_fertilization1.02797274
90MP0003172_abnormal_lysosome_physiology1.00713422
91MP0001929_abnormal_gametogenesis1.00251439
92MP0000747_muscle_weakness0.97700875
93MP0006138_congestive_heart_failure0.96884297
94* MP0002111_abnormal_tail_morphology0.96725256
95MP0010630_abnormal_cardiac_muscle0.96632308
96MP0009931_abnormal_skin_appearance0.96345180
97MP0003693_abnormal_embryo_hatching0.95869146
98MP0000759_abnormal_skeletal_muscle0.95718940
99MP0002060_abnormal_skin_morphology0.95509104
100MP0002019_abnormal_tumor_incidence0.95063667
101MP0005670_abnormal_white_adipose0.94706492
102MP0004087_abnormal_muscle_fiber0.94376921
103MP0002210_abnormal_sex_determination0.94318892
104MP0000467_abnormal_esophagus_morphology0.94000134
105MP0003755_abnormal_palate_morphology0.93827142
106MP0004185_abnormal_adipocyte_glucose0.93368156
107MP0000432_abnormal_head_morphology0.93010530
108MP0003115_abnormal_respiratory_system0.92738702
109MP0000858_altered_metastatic_potential0.92019782
110MP0002092_abnormal_eye_morphology0.91023475
111MP0005621_abnormal_cell_physiology0.90901847
112MP0009384_cardiac_valve_regurgitation0.88424902
113MP0005023_abnormal_wound_healing0.87760677
114MP0002114_abnormal_axial_skeleton0.87628048
115MP0000762_abnormal_tongue_morphology0.87556740
116MP0009840_abnormal_foam_cell0.86800744
117MP0004947_skin_inflammation0.85070019
118MP0002116_abnormal_craniofacial_bone0.84884708
119MP0001958_emphysema0.83769428
120MP0001346_abnormal_lacrimal_gland0.82748122
121MP0002896_abnormal_bone_mineralization0.82226826
122MP0009379_abnormal_foot_pigmentation0.81936448
123MP0002925_abnormal_cardiovascular_devel0.81723117
124MP0000313_abnormal_cell_death0.81677481
125MP0000733_abnormal_muscle_development0.81535707
126MP0001784_abnormal_fluid_regulation0.80893683
127MP0010678_abnormal_skin_adnexa0.80472405
128MP0002254_reproductive_system_inflammat0.80079250
129MP0004782_abnormal_surfactant_physiolog0.79503878
130* MP0001340_abnormal_eyelid_morphology0.77529661
131MP0000537_abnormal_urethra_morphology0.77435310
132MP0003698_abnormal_male_reproductive0.77265644
133MP0005508_abnormal_skeleton_morphology0.77235710
134MP0000013_abnormal_adipose_tissue0.77086899
135MP0003279_aneurysm0.76623536
136MP0001873_stomach_inflammation0.76079986
137MP0000653_abnormal_sex_gland0.74930065
138MP0000767_abnormal_smooth_muscle0.74215483
139MP0000639_abnormal_adrenal_gland0.73955614
140MP0002075_abnormal_coat/hair_pigmentati0.73125720
141MP0001915_intracranial_hemorrhage0.73090180
142* MP0002697_abnormal_eye_size0.72422060
143MP0009703_decreased_birth_body0.72173686
144MP0003634_abnormal_glial_cell0.71829713
145MP0009115_abnormal_fat_cell0.71561630
146MP0003329_amyloid_beta_deposits0.71144638
147MP0003191_abnormal_cellular_cholesterol0.70145643
148MP0009780_abnormal_chondrocyte_physiolo0.69624387
149MP0001661_extended_life_span0.69235807
150MP0003828_pulmonary_edema0.67477099
151MP0002161_abnormal_fertility/fecundity0.67431849
152MP0000428_abnormal_craniofacial_morphol0.66094613
153MP0000477_abnormal_intestine_morphology0.65233058
154* MP0000470_abnormal_stomach_morphology0.64755678
155MP0000266_abnormal_heart_morphology0.64413201
156MP0003942_abnormal_urinary_system0.64340216

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.82485650
2Ulnar bowing (HP:0003031)4.42985516
3Annular pancreas (HP:0001734)4.22484700
4Turricephaly (HP:0000262)4.20770451
5Facial hemangioma (HP:0000329)4.17845149
6Male infertility (HP:0003251)4.09134695
7Alopecia of scalp (HP:0002293)3.84130533
8Pustule (HP:0200039)3.74423880
9Rectal fistula (HP:0100590)3.63885113
10Rectovaginal fistula (HP:0000143)3.63885113
11Poikiloderma (HP:0001029)3.63449778
12Concave nail (HP:0001598)3.59163437
13Intestinal fistula (HP:0100819)3.57644082
14Short humerus (HP:0005792)3.49585223
15Broad face (HP:0000283)3.47438428
16Cerebral aneurysm (HP:0004944)3.45134682
17Coronal craniosynostosis (HP:0004440)3.36940010
18Aplasia/hypoplasia of the humerus (HP:0006507)3.24838641
19Vaginal fistula (HP:0004320)3.24640512
20Distal lower limb amyotrophy (HP:0008944)3.19732097
21Selective tooth agenesis (HP:0001592)3.17013325
22Tongue fasciculations (HP:0001308)3.12559665
23Obstructive sleep apnea (HP:0002870)3.10846233
24Abnormality of the lower motor neuron (HP:0002366)2.99801116
25Muscle fibrillation (HP:0010546)2.99204372
26Astrocytoma (HP:0009592)2.98461600
27Abnormality of the astrocytes (HP:0100707)2.98461600
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.95352470
29Basal cell carcinoma (HP:0002671)2.92540818
30Premature rupture of membranes (HP:0001788)2.91682545
31Vertebral hypoplasia (HP:0008417)2.90047188
32Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.90047188
33Increased connective tissue (HP:0009025)2.88175004
34Hypochromic microcytic anemia (HP:0004840)2.86308239
35Flat acetabular roof (HP:0003180)2.85004992
36Congenital hip dislocation (HP:0001374)2.83383374
37Squamous cell carcinoma (HP:0002860)2.74956005
38Orthostatic hypotension (HP:0001278)2.73467805
39Distal upper limb amyotrophy (HP:0007149)2.73241835
40Upper limb amyotrophy (HP:0009129)2.73241835
41Protrusio acetabuli (HP:0003179)2.71377613
42Shallow orbits (HP:0000586)2.67730482
43Anteriorly placed anus (HP:0001545)2.64010765
44Distal lower limb muscle weakness (HP:0009053)2.63633525
45Increased IgM level (HP:0003496)2.63178435
46Cervical subluxation (HP:0003308)2.63177091
47Ependymoma (HP:0002888)2.61487878
48Fragile skin (HP:0001030)2.61202105
49Volvulus (HP:0002580)2.60211855
50Achilles tendon contracture (HP:0001771)2.59143828
51Absent radius (HP:0003974)2.56484110
52Hamartoma (HP:0010566)2.55019642
53Bowed forearm bones (HP:0003956)2.51376970
54Bowing of the arm (HP:0006488)2.51376970
55Abnormality of the aortic arch (HP:0012303)2.50976665
56Disproportionate tall stature (HP:0001519)2.49741838
57Mildly elevated creatine phosphokinase (HP:0008180)2.47312968
58Short chin (HP:0000331)2.46984502
59Intestinal atresia (HP:0011100)2.45288104
60Insomnia (HP:0100785)2.42706634
61Lower limb amyotrophy (HP:0007210)2.42151491
62Abnormality of male internal genitalia (HP:0000022)2.42034482
63Alacrima (HP:0000522)2.41971888
64Vertebral fusion (HP:0002948)2.41730101
65Absent forearm bone (HP:0003953)2.40583686
66Aplasia involving forearm bones (HP:0009822)2.40583686
67Stridor (HP:0010307)2.40550695
68Broad alveolar ridges (HP:0000187)2.40075734
69Diaphragmatic weakness (HP:0009113)2.37362327
70Abnormal hemoglobin (HP:0011902)2.37225065
71Heterotopia (HP:0002282)2.36732480
72Premature skin wrinkling (HP:0100678)2.33921584
73Absent thumb (HP:0009777)2.32566415
74Thin bony cortex (HP:0002753)2.30703138
75Long palpebral fissure (HP:0000637)2.27707132
76Abnormality of the Achilles tendon (HP:0005109)2.27278526
77Neoplasm of the oral cavity (HP:0100649)2.26007292
78Atrophic scars (HP:0001075)2.23674650
79Hypotelorism (HP:0000601)2.23411769
80Difficulty climbing stairs (HP:0003551)2.23349050
81Hypotrichosis (HP:0001006)2.22639314
82Advanced eruption of teeth (HP:0006288)2.21214401
83Large for gestational age (HP:0001520)2.18810118
84Asymmetry of the thorax (HP:0001555)2.16805352
85J-shaped sella turcica (HP:0002680)2.14863537
86Spinal rigidity (HP:0003306)2.13716705
87Choanal stenosis (HP:0000452)2.13133903
88Spinal muscular atrophy (HP:0007269)2.11777417
89Glioma (HP:0009733)2.11536479
90Abnormality of the distal phalanx of the thumb (HP:0009617)2.09712636
91Short nail (HP:0001799)2.09073894
92Thin ribs (HP:0000883)2.08841929
93Mitral regurgitation (HP:0001653)2.08769914
94Polycythemia (HP:0001901)2.07053334
95Patellar aplasia (HP:0006443)2.05229100
96Albinism (HP:0001022)2.04712745
97Mucopolysacchariduria (HP:0008155)2.03854202
98Urinary glycosaminoglycan excretion (HP:0003541)2.03854202
99Missing ribs (HP:0000921)2.00901796
100Bronchomalacia (HP:0002780)2.00416573
101Pointed chin (HP:0000307)2.00292800
102Split hand (HP:0001171)2.00063807
103Natal tooth (HP:0000695)1.99793397
104Ankyloglossia (HP:0010296)1.99519217
105Abnormality of the thoracic spine (HP:0100711)1.99437124
106Metaphyseal cupping (HP:0003021)1.99197460
107Hyperacusis (HP:0010780)1.99181073
108Pancreatic islet-cell hyperplasia (HP:0004510)1.98922796
109Abnormality of the distal phalanges of the toes (HP:0010182)1.98399233
110Urethral obstruction (HP:0000796)1.96780996
111Trismus (HP:0000211)1.96117640
112Short 5th finger (HP:0009237)1.95820340
113Elfin facies (HP:0004428)1.95293225
114Patellar dislocation (HP:0002999)1.92380943
115Abnormality of the labia minora (HP:0012880)1.92273146
116Bladder diverticulum (HP:0000015)1.90417574
117Overriding aorta (HP:0002623)1.90371000
118Hypercortisolism (HP:0001578)1.89652587
119Flattened epiphyses (HP:0003071)1.88900212
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.88800104
121Gastrointestinal atresia (HP:0002589)1.88404785
122Broad thumb (HP:0011304)1.86840707
123Joint stiffness (HP:0001387)1.85861675
124Aplasia/Hypoplasia of the patella (HP:0006498)1.85650129
125Biconcave vertebral bodies (HP:0004586)1.85324596
126Growth hormone excess (HP:0000845)1.84433827
127Abnormality of oral frenula (HP:0000190)1.83939655
128Decreased lacrimation (HP:0000633)1.83086665
129Abnormality of the calcaneus (HP:0008364)1.82507688
130Dysautonomia (HP:0002459)1.81302985
131Lymphangioma (HP:0100764)1.81230935
132Milia (HP:0001056)1.79865972
133IgA deficiency (HP:0002720)1.78421298
134Hypochromic anemia (HP:0001931)1.78320678
135Abnormality of polysaccharide metabolism (HP:0011012)1.78284580
136Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78284580
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78284580
138Myopathic facies (HP:0002058)1.78173318
139Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.76543969
140Clumsiness (HP:0002312)1.76495419
141Abnormal number of incisors (HP:0011064)1.76336095
142Abnormal vertebral ossification (HP:0100569)1.75516776
143Right ventricular cardiomyopathy (HP:0011663)1.75258977
144Narrow nasal bridge (HP:0000446)1.75168813
145Hyperparathyroidism (HP:0000843)1.74820863
146Asymmetric septal hypertrophy (HP:0001670)1.74402219
147Pseudobulbar signs (HP:0002200)1.74189731
148Broad distal phalanx of finger (HP:0009836)1.73163079
149Infertility (HP:0000789)1.72844686
150Hand muscle atrophy (HP:0009130)1.72692232
151Deviation of the thumb (HP:0009603)1.72578334
152Pterygium (HP:0001059)1.72474522
153Renal duplication (HP:0000075)1.71901530
154Acute lymphatic leukemia (HP:0006721)1.70937245
155Short phalanx of the thumb (HP:0009660)1.70666981
156Arnold-Chiari malformation (HP:0002308)1.70386142
157Elbow flexion contracture (HP:0002987)1.70109776
158Increased variability in muscle fiber diameter (HP:0003557)1.69939500
159Neonatal short-limb short stature (HP:0008921)1.69823856
160Vertebral arch anomaly (HP:0008438)1.69523825
161Dysmetric saccades (HP:0000641)1.69351273
162Easy fatigability (HP:0003388)1.68538998
163Vertebral compression fractures (HP:0002953)1.68414442
164Aplasia involving bones of the extremities (HP:0009825)1.67937962
165Aplasia involving bones of the upper limbs (HP:0009823)1.67937962
166Aplasia of the phalanges of the hand (HP:0009802)1.67937962
167Generalized amyotrophy (HP:0003700)1.67019107
168Bulbar palsy (HP:0001283)1.66997494
169Short 4th metacarpal (HP:0010044)1.66947082
170Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66947082
171Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66353385
172Absent epiphyses (HP:0010577)1.66353385
173Germ cell neoplasia (HP:0100728)1.66223839
174Abnormality of the salivary glands (HP:0010286)1.65534574
175Precocious puberty (HP:0000826)1.65478885
176Blue sclerae (HP:0000592)1.63787844
177Abnormality of nail color (HP:0100643)1.63740984
178Pili torti (HP:0003777)1.63409591
179Flared metaphyses (HP:0003015)1.63046761
180Glossoptosis (HP:0000162)1.62663404
181Acanthosis nigricans (HP:0000956)1.60485940
182Renovascular hypertension (HP:0100817)1.60293584
183Spinal cord compression (HP:0002176)1.59940807
184Hemorrhage of the eye (HP:0011885)1.59789718
185Dislocated radial head (HP:0003083)1.59705869
186Proximal placement of thumb (HP:0009623)1.56236132
187Abdominal distention (HP:0003270)1.54703762
188Midface retrusion (HP:0011800)1.54512473
189Increased nuchal translucency (HP:0010880)1.54127716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.25802762
2DDR24.26738949
3MAPK153.92639915
4SMG13.67863622
5MAP3K63.34470049
6TYRO33.27992857
7MST1R2.86623917
8IRAK32.73095927
9MAP3K112.58487159
10MAP3K102.44518644
11BMX2.40044298
12CDK122.37802123
13PDGFRA2.31118930
14PRPF4B2.23936036
15FGR2.23251682
16MATK2.22027440
17TRIB32.14346257
18PINK11.97533965
19DYRK1B1.95028195
20PRKD21.89112342
21UHMK11.83771542
22CSK1.79014413
23NME21.77216170
24DAPK11.72270407
25CDK71.69517053
26MET1.61161334
27FGFR41.54056308
28CDK61.52512917
29LMTK21.42937770
30EEF2K1.40575686
31YES11.34159594
32MTOR1.32834357
33NEK21.31718616
34LATS21.31001742
35PIM11.19511038
36TRPM71.16716808
37NTRK11.16258075
38PIM21.15906466
39RIPK11.10374139
40CDC42BPA1.08062115
41RPS6KC11.07410560
42RPS6KL11.07410560
43TESK11.02173380
44CHEK20.98396172
45CDC70.97058570
46EPHA20.96740011
47GSK3A0.95773874
48PKN20.94366873
49RPS6KA60.92232227
50RPS6KA20.91728582
51PRKD30.91289599
52LATS10.89943626
53MAPK110.86912248
54RPS6KB20.85215449
55IRAK20.85111864
56ALK0.80018648
57EPHB10.79984375
58MAP2K30.79921413
59PLK10.78173185
60MAP3K130.77211003
61MAP2K20.75443796
62CDK40.75304040
63TTN0.74367646
64RPS6KA10.73734780
65EPHB20.73672196
66DYRK30.73008164
67ATR0.72558293
68ARAF0.72506082
69PAK20.71848416
70PHKG20.71765507
71PHKG10.71765507
72STK30.69718448
73SCYL20.68747787
74PDGFRB0.68538517
75AKT30.66699427
76PAK40.66381203
77CDK20.63338874
78HIPK20.62891372
79CHEK10.62855416
80KSR20.62441030
81ILK0.62429282
82SIK10.62297709
83PDPK10.61591890
84CAMK1D0.59487649
85PRKAA10.58908968
86PDK40.57569147
87PDK30.57569147
88BRAF0.56931476
89PTK60.56767007
90PTK20.54568089
91STK100.54520927
92TAOK10.54109605
93MAP3K30.53207603
94SIK20.51749201
95MAP3K10.51108098
96SIK30.49395588
97PRKCI0.48663280
98EGFR0.48444719
99ERN10.47434379
100TTK0.46947503
101ATM0.46803899
102RET0.46016138
103MAPK10.44542149
104LRRK20.44442599
105CDK80.43819199
106MAP3K70.43738948
107FGFR10.43623083
108DMPK0.43027766
109PRKG20.41329557
110MUSK0.41061248
111BRD40.39675503
112STK380.38965621
113NEK10.37894162
114CDK10.36359366
115MAPK140.35917323
116RPS6KB10.35217118
117CDK90.35135628
118TESK20.35030165
119AURKB0.33906949
120MAP4K10.33531500
121MAP3K90.33459094
122CAMK1G0.33299070
123MAP3K80.33061130
124MAPK100.32489661
125CAMKK10.31259869
126CAMK2G0.31252883
127MAPK30.30286960
128MARK20.30138282
129CHUK0.30117049
130PAK60.29102739
131NME10.28667271
132INSR0.28505234
133AURKA0.28260303
134IRAK40.27865921
135CAMK2B0.27069043
136MAPK80.26389194
137MAPKAPK30.26311418
138GSK3B0.26042781
139AKT20.24949706
140PAK10.24949017
141TAOK20.24745571
142PRKDC0.24575793
143ROCK20.24446308
144MAPKAPK20.24391830
145TNK20.24039130

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.65108362
2Mismatch repair_Homo sapiens_hsa034303.76446209
3Base excision repair_Homo sapiens_hsa034103.71604799
4DNA replication_Homo sapiens_hsa030303.00137451
5mRNA surveillance pathway_Homo sapiens_hsa030152.36475839
6Notch signaling pathway_Homo sapiens_hsa043302.36387783
7mTOR signaling pathway_Homo sapiens_hsa041502.25762840
8Hedgehog signaling pathway_Homo sapiens_hsa043402.16584024
9RNA transport_Homo sapiens_hsa030132.08484185
10Adherens junction_Homo sapiens_hsa045201.94244033
11Spliceosome_Homo sapiens_hsa030401.91345621
12* Hippo signaling pathway_Homo sapiens_hsa043901.88592100
13Lysine degradation_Homo sapiens_hsa003101.85807445
14Basal cell carcinoma_Homo sapiens_hsa052171.82161000
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81542590
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74208982
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72245431
18Other glycan degradation_Homo sapiens_hsa005111.64515358
19Nucleotide excision repair_Homo sapiens_hsa034201.61564875
20Pentose phosphate pathway_Homo sapiens_hsa000301.60865865
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55227801
22Bladder cancer_Homo sapiens_hsa052191.52425851
23Cell cycle_Homo sapiens_hsa041101.46564337
24Biosynthesis of amino acids_Homo sapiens_hsa012301.46132469
25Longevity regulating pathway - mammal_Homo sapiens_hsa042111.43171126
26p53 signaling pathway_Homo sapiens_hsa041151.41485038
27Dorso-ventral axis formation_Homo sapiens_hsa043201.41198295
28Fanconi anemia pathway_Homo sapiens_hsa034601.39177384
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36015080
30TGF-beta signaling pathway_Homo sapiens_hsa043501.35461189
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34401997
32Chronic myeloid leukemia_Homo sapiens_hsa052201.31934338
33Prion diseases_Homo sapiens_hsa050201.31014072
34Vitamin B6 metabolism_Homo sapiens_hsa007501.29045203
35Wnt signaling pathway_Homo sapiens_hsa043101.28007445
36MicroRNAs in cancer_Homo sapiens_hsa052061.27459272
37VEGF signaling pathway_Homo sapiens_hsa043701.26499961
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25288288
39Renal cell carcinoma_Homo sapiens_hsa052111.24788255
40Small cell lung cancer_Homo sapiens_hsa052221.22258417
41Homologous recombination_Homo sapiens_hsa034401.22096790
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20898168
43Arginine and proline metabolism_Homo sapiens_hsa003301.15378997
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14381554
45Colorectal cancer_Homo sapiens_hsa052101.14070560
46Circadian rhythm_Homo sapiens_hsa047101.09260759
47Fatty acid metabolism_Homo sapiens_hsa012121.09084851
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06862499
49GnRH signaling pathway_Homo sapiens_hsa049121.06458621
50Oocyte meiosis_Homo sapiens_hsa041141.06351957
51Tight junction_Homo sapiens_hsa045301.05888827
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05258980
53Sulfur relay system_Homo sapiens_hsa041221.04976769
54Shigellosis_Homo sapiens_hsa051311.02101521
55Viral myocarditis_Homo sapiens_hsa054161.01648743
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.99089271
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.97115567
58Axon guidance_Homo sapiens_hsa043600.95123733
59One carbon pool by folate_Homo sapiens_hsa006700.94849786
60Proteoglycans in cancer_Homo sapiens_hsa052050.93426670
61Inositol phosphate metabolism_Homo sapiens_hsa005620.93085049
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92812941
63Melanogenesis_Homo sapiens_hsa049160.92101178
64Acute myeloid leukemia_Homo sapiens_hsa052210.91445460
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91387418
66AMPK signaling pathway_Homo sapiens_hsa041520.88325056
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87830001
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87278061
69Focal adhesion_Homo sapiens_hsa045100.85113593
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.84735050
71Prolactin signaling pathway_Homo sapiens_hsa049170.82459508
72Fructose and mannose metabolism_Homo sapiens_hsa000510.81788230
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80081667
74Endometrial cancer_Homo sapiens_hsa052130.79903504
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79161179
76Insulin signaling pathway_Homo sapiens_hsa049100.78263766
77Hepatitis C_Homo sapiens_hsa051600.77425422
78Amoebiasis_Homo sapiens_hsa051460.76558071
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75196898
80ErbB signaling pathway_Homo sapiens_hsa040120.74625398
81HTLV-I infection_Homo sapiens_hsa051660.73894987
82* Viral carcinogenesis_Homo sapiens_hsa052030.72972968
83Thyroid cancer_Homo sapiens_hsa052160.72127347
84Dilated cardiomyopathy_Homo sapiens_hsa054140.71822538
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70668049
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70451764
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70097457
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.68360876
89Melanoma_Homo sapiens_hsa052180.68148416
90Apoptosis_Homo sapiens_hsa042100.66103012
91Selenocompound metabolism_Homo sapiens_hsa004500.66062668
92Choline metabolism in cancer_Homo sapiens_hsa052310.61795681
93Vibrio cholerae infection_Homo sapiens_hsa051100.61321513
94N-Glycan biosynthesis_Homo sapiens_hsa005100.60520444
95Carbon metabolism_Homo sapiens_hsa012000.59654967
96Primary immunodeficiency_Homo sapiens_hsa053400.59091036
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.58730992
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58363376
99Arginine biosynthesis_Homo sapiens_hsa002200.57903201
100Pathways in cancer_Homo sapiens_hsa052000.57600578
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57200414
102B cell receptor signaling pathway_Homo sapiens_hsa046620.55078452
103Long-term potentiation_Homo sapiens_hsa047200.54936582
104Prostate cancer_Homo sapiens_hsa052150.54667711
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.54331167
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54066473
107Estrogen signaling pathway_Homo sapiens_hsa049150.54028256
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53911686
109Gap junction_Homo sapiens_hsa045400.53080394
110Pancreatic cancer_Homo sapiens_hsa052120.52138604
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51360716
112Bile secretion_Homo sapiens_hsa049760.50581597
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49380167
114Glucagon signaling pathway_Homo sapiens_hsa049220.46626893
115Non-small cell lung cancer_Homo sapiens_hsa052230.46357583
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45393795
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44673092
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44197393
119MAPK signaling pathway_Homo sapiens_hsa040100.44087029
120Endocytosis_Homo sapiens_hsa041440.42106261
121Herpes simplex infection_Homo sapiens_hsa051680.41993869
122Legionellosis_Homo sapiens_hsa051340.41590021
123HIF-1 signaling pathway_Homo sapiens_hsa040660.37937858
124Glioma_Homo sapiens_hsa052140.34978570
125Hepatitis B_Homo sapiens_hsa051610.34915019
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32926616
127Epstein-Barr virus infection_Homo sapiens_hsa051690.32705139
128Rap1 signaling pathway_Homo sapiens_hsa040150.31121249
129Insulin resistance_Homo sapiens_hsa049310.29247589
130ECM-receptor interaction_Homo sapiens_hsa045120.28290325
131Galactose metabolism_Homo sapiens_hsa000520.27785092
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.25951073
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.24208484

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