ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	polyketide metabolic process (GO:0030638)	6.19507968
2	doxorubicin metabolic process (GO:0044598)	6.19507968
3	daunorubicin metabolic process (GO:0044597)	6.19507968
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.93951490
5	L-phenylalanine metabolic process (GO:0006558)	5.93951490
6	sulfur amino acid catabolic process (GO:0000098)	5.74799732
7	L-phenylalanine catabolic process (GO:0006559)	5.72544537
8	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.72544537
9	aminoglycoside antibiotic metabolic process (GO:0030647)	5.68457675
10	cellular modified amino acid catabolic process (GO:0042219)	5.42041250
11	aromatic amino acid family catabolic process (GO:0009074)	5.32686984
12	coenzyme catabolic process (GO:0009109)	5.30407979
13	glyoxylate metabolic process (GO:0046487)	5.28073166
14	NADH metabolic process (GO:0006734)	5.01594773
15	indole-containing compound catabolic process (GO:0042436)	4.96490093
16	indolalkylamine catabolic process (GO:0046218)	4.96490093
17	tryptophan catabolic process (GO:0006569)	4.96490093
18	cysteine metabolic process (GO:0006534)	4.90331362
19	kynurenine metabolic process (GO:0070189)	4.79119261
20	lysine catabolic process (GO:0006554)	4.76655119
21	lysine metabolic process (GO:0006553)	4.76655119
22	serine family amino acid catabolic process (GO:0009071)	4.72748309
23	tryptophan metabolic process (GO:0006568)	4.63701584
24	tricarboxylic acid metabolic process (GO:0072350)	4.52224209
25	triglyceride catabolic process (GO:0019433)	4.39484767
26	glycine metabolic process (GO:0006544)	4.37692294
27	bile acid biosynthetic process (GO:0006699)	4.34233595
28	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.24654793
29	serine family amino acid metabolic process (GO:0009069)	4.21408476
30	low-density lipoprotein particle clearance (GO:0034383)	4.19755974
31	epoxygenase P450 pathway (GO:0019373)	4.17957881
32	serine family amino acid biosynthetic process (GO:0009070)	4.17788924
33	UV protection (GO:0009650)	4.11208295
34	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.06625619
35	acylglycerol catabolic process (GO:0046464)	4.03671026
36	neutral lipid catabolic process (GO:0046461)	4.03671026
37	urea metabolic process (GO:0019627)	3.99854402
38	urea cycle (GO:0000050)	3.99854402
39	valine metabolic process (GO:0006573)	3.98274324
40	amino-acid betaine metabolic process (GO:0006577)	3.96976131
41	drug metabolic process (GO:0017144)	3.96529692
42	aromatic amino acid family metabolic process (GO:0009072)	3.95679114
43	cellular amino acid catabolic process (GO:0009063)	3.95395338
44	proline biosynthetic process (GO:0006561)	3.95276846
45	homocysteine metabolic process (GO:0050667)	3.94320369
46	alpha-linolenic acid metabolic process (GO:0036109)	3.93937463
47	alpha-amino acid catabolic process (GO:1901606)	3.92949090
48	primary alcohol catabolic process (GO:0034310)	3.92787650
49	positive regulation of triglyceride lipase activity (GO:0061365)	3.91885478
50	positive regulation of lipoprotein lipase activity (GO:0051006)	3.91885478
51	heme transport (GO:0015886)	3.90421867
52	hormone catabolic process (GO:0042447)	3.87890389
53	urate metabolic process (GO:0046415)	3.86457493
54	negative regulation of fibrinolysis (GO:0051918)	3.84063448
55	drug transmembrane transport (GO:0006855)	3.83855483
56	cofactor catabolic process (GO:0051187)	3.83769287
57	oxaloacetate metabolic process (GO:0006107)	3.80815982
58	diacylglycerol metabolic process (GO:0046339)	3.79593752
59	protein retention in ER lumen (GO:0006621)	3.75145460
60	nitrogen cycle metabolic process (GO:0071941)	3.67611815
61	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.66374200
62	negative regulation of erythrocyte differentiation (GO:0045647)	3.65139794
63	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.64531291
64	high-density lipoprotein particle remodeling (GO:0034375)	3.64394239
65	flavonoid metabolic process (GO:0009812)	3.59549529
66	bile acid metabolic process (GO:0008206)	3.57463438
67	branched-chain amino acid catabolic process (GO:0009083)	3.56227504
68	ethanol oxidation (GO:0006069)	3.56072337
69	drug catabolic process (GO:0042737)	3.55054846
70	COPI coating of Golgi vesicle (GO:0048205)	3.52307142
71	Golgi transport vesicle coating (GO:0048200)	3.52307142
72	regulation of fibrinolysis (GO:0051917)	3.51707819
73	peptidyl-arginine omega-N-methylation (GO:0035247)	3.50927908
74	phosphatidylglycerol biosynthetic process (GO:0006655)	3.47174747
75	biotin metabolic process (GO:0006768)	3.45813859
76	negative regulation of sterol transport (GO:0032372)	3.44711592
77	negative regulation of cholesterol transport (GO:0032375)	3.44711592
78	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.44549421
79	imidazole-containing compound metabolic process (GO:0052803)	3.43867123
80	drug transport (GO:0015893)	3.41679981
81	branched-chain amino acid metabolic process (GO:0009081)	3.39788684
82	pentose-phosphate shunt (GO:0006098)	3.39644378
83	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.38134326
84	protein carboxylation (GO:0018214)	3.36084821
85	peptidyl-glutamic acid carboxylation (GO:0017187)	3.36084821
86	glucose catabolic process (GO:0006007)	3.35725181
87	benzene-containing compound metabolic process (GO:0042537)	3.35595465
88	indolalkylamine metabolic process (GO:0006586)	3.35573028
89	organic acid catabolic process (GO:0016054)	3.35449102
90	carboxylic acid catabolic process (GO:0046395)	3.35449102
91	pteridine-containing compound biosynthetic process (GO:0042559)	3.32848619
92	regulation of protein activation cascade (GO:2000257)	3.32511718
93	negative regulation of epidermis development (GO:0045683)	3.31477845
94	fatty acid catabolic process (GO:0009062)	3.28031973
95	aspartate family amino acid catabolic process (GO:0009068)	3.27765616
96	proline metabolic process (GO:0006560)	3.27335866
97	protein maturation by protein folding (GO:0022417)	3.25382461
98	negative regulation of cell size (GO:0045792)	3.24742478
99	short-chain fatty acid metabolic process (GO:0046459)	3.24462403
100	cellular ketone body metabolic process (GO:0046950)	3.24056919
101	GDP-mannose metabolic process (GO:0019673)	3.23362633
102	xenobiotic catabolic process (GO:0042178)	3.22779509
103	iron-sulfur cluster assembly (GO:0016226)	3.22664960
104	metallo-sulfur cluster assembly (GO:0031163)	3.22664960
105	regulation of cholesterol esterification (GO:0010872)	3.21619689
106	regulation of triglyceride catabolic process (GO:0010896)	3.20411435
107	amine catabolic process (GO:0009310)	3.20159675
108	cellular biogenic amine catabolic process (GO:0042402)	3.20159675
109	tyrosine metabolic process (GO:0006570)	3.19477308
110	complement activation, alternative pathway (GO:0006957)	3.19413380
111	2-oxoglutarate metabolic process (GO:0006103)	3.18750107
112	exogenous drug catabolic process (GO:0042738)	3.17678611
113	negative regulation of granulocyte differentiation (GO:0030853)	3.17135704
114	pyrimidine nucleotide catabolic process (GO:0006244)	3.16118976
115	organic cation transport (GO:0015695)	3.15644180
116	cellular glucuronidation (GO:0052695)	3.14405923
117	glutamate metabolic process (GO:0006536)	3.13590782
118	triglyceride homeostasis (GO:0070328)	3.12333869
119	acylglycerol homeostasis (GO:0055090)	3.12333869
120	L-serine metabolic process (GO:0006563)	3.11947255
121	ethanol metabolic process (GO:0006067)	3.11746975
122	sulfur amino acid metabolic process (GO:0000096)	3.11553742
123	acetyl-CoA metabolic process (GO:0006084)	3.09388778
124	creatine metabolic process (GO:0006600)	3.09260376
125	regulation of complement activation (GO:0030449)	3.08627300
126	aldehyde catabolic process (GO:0046185)	3.08109769
127	fatty acid beta-oxidation (GO:0006635)	3.06655578
128	carnitine metabolic process (GO:0009437)	3.06546193
129	cofactor transport (GO:0051181)	3.05417522
130	reverse cholesterol transport (GO:0043691)	3.04110590
131	folic acid metabolic process (GO:0046655)	3.02986077
132	NADPH regeneration (GO:0006740)	3.01210140
133	response to mercury ion (GO:0046689)	3.00983241
134	plasma lipoprotein particle remodeling (GO:0034369)	3.00947969
135	protein-lipid complex remodeling (GO:0034368)	3.00947969
136	macromolecular complex remodeling (GO:0034367)	3.00947969
137	regulation of cholesterol metabolic process (GO:0090181)	2.99087372
138	monocarboxylic acid catabolic process (GO:0072329)	2.91880352
139	barbed-end actin filament capping (GO:0051016)	2.91004323
140	fatty acid homeostasis (GO:0055089)	2.90637527
141	arginine catabolic process (GO:0006527)	2.90449836
142	fatty acid oxidation (GO:0019395)	2.90334047
143	regulation of cholesterol storage (GO:0010885)	2.89574631
144	base-excision repair, AP site formation (GO:0006285)	2.85811366
145	glycerolipid catabolic process (GO:0046503)	2.82414570
146	lipid oxidation (GO:0034440)	2.81820737
147	4-hydroxyproline metabolic process (GO:0019471)	2.79168526
148	CDP-diacylglycerol metabolic process (GO:0046341)	2.78978439
149	negative regulation of B cell apoptotic process (GO:0002903)	2.77730052
150	gluconeogenesis (GO:0006094)	2.73444456
151	monosaccharide biosynthetic process (GO:0046364)	2.71186103
152	heme biosynthetic process (GO:0006783)	2.69279606
153	response to misfolded protein (GO:0051788)	2.68679755
154	deoxyribonucleotide catabolic process (GO:0009264)	2.67285753
155	peptidyl-arginine methylation (GO:0018216)	2.65179512
156	peptidyl-arginine N-methylation (GO:0035246)	2.65179512
157	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.64363244
158	autophagic vacuole fusion (GO:0000046)	2.64149934
159	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.63344354
160	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.60627264
161	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.60153524
162	regulation of sequestering of triglyceride (GO:0010889)	2.59399842
163	positive regulation of fatty acid biosynthetic process (GO:0045723)	2.54524346
164	heme metabolic process (GO:0042168)	2.53591449
165	negative regulation of smooth muscle cell migration (GO:0014912)	2.53276138
166	glutamine family amino acid biosynthetic process (GO:0009084)	2.53101010
167	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	2.53097865
168	lipid storage (GO:0019915)	2.52066754
169	endothelium development (GO:0003158)	2.48717620
170	histone arginine methylation (GO:0034969)	2.48385034
171	purine deoxyribonucleotide catabolic process (GO:0009155)	2.48292965
172	positive regulation of receptor biosynthetic process (GO:0010870)	2.47966491
173	pentose metabolic process (GO:0019321)	2.47234130
174	mannose metabolic process (GO:0006013)	2.45525258
175	positive regulation of triglyceride metabolic process (GO:0090208)	2.44551056
176	angiogenesis involved in wound healing (GO:0060055)	2.44217864

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	6.35693786
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	4.50830220
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.08747261
4	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.58765119
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.44808248
6	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.31808695
7	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.31808695
8	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.31808695
9	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.29215175
10	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.15643893
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.12142590
12	E2F7_22180533_ChIP-Seq_HELA_Human	2.77175029
13	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.75085033
14	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.61622823
15	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.57583433
16	VDR_21846776_ChIP-Seq_THP-1_Human	2.53424236
17	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.45682370
18	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.35316365
19	ZNF263_19887448_ChIP-Seq_K562_Human	2.24505630
20	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.14359783
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.13680463
22	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	2.13513057
23	STAT3_1855785_ChIP-Seq_MESCs_Mouse	2.01872690
24	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.95005746
25	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.88196896
26	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.87819347
27	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.83318247
28	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.74713878
29	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.73792766
30	BCL6_27268052_Chip-Seq_Bcells_Human	1.67716074
31	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.67678307
32	* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.66767820
33	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.63929651
34	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.63907975
35	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.63120697
36	* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.61943170
37	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.58779641
38	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.58201762
39	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.57769168
40	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.50401521
41	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.48926720
42	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.47122799
43	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.45713923
44	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.44126187
45	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.43743866
46	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.43693061
47	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.42162307
48	KDM2B_26808549_Chip-Seq_DND41_Human	1.41410379
49	* CTCF_26484167_Chip-Seq_Bcells_Mouse	1.40774162
50	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.39539232
51	CLOCK_20551151_ChIP-Seq_293T_Human	1.38308841
52	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.37304872
53	* SMC4_20622854_ChIP-Seq_HELA_Human	1.35039244
54	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.34453214
55	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.34024928
56	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.33531473
57	MYC_22102868_ChIP-Seq_BL_Human	1.33500136
58	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.33054732
59	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.32484115
60	* CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.32055251
61	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.32029129
62	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.31918559
63	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.29371593
64	PHF8_20622854_ChIP-Seq_HELA_Human	1.27065700
65	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.26470787
66	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.25449154
67	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.23399138
68	CTCF_27219007_Chip-Seq_Bcells_Human	1.22830597
69	MAF_26560356_Chip-Seq_TH2_Human	1.21922972
70	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.21633544
71	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.21108019
72	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.21080191
73	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.21003132
74	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.19816392
75	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19758162
76	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.19345171
77	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.19333287
78	AR_21909140_ChIP-Seq_LNCAP_Human	1.19198020
79	E2F1_20622854_ChIP-Seq_HELA_Human	1.18692510
80	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.18563544
81	* TCF7_22412390_ChIP-Seq_EML_Mouse	1.18443470
82	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.18304574
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18282406
84	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.17203231
85	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17149721
86	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.16972503
87	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.16458143
88	SOX2_18692474_ChIP-Seq_MEFs_Mouse	1.13466839
89	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.12986172
90	SCL_19346495_ChIP-Seq_HPC-7_Human	1.12498426
91	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.11992396
92	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.11690960
93	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.11495009
94	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.10928138
95	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10838691
96	VDR_24763502_ChIP-Seq_THP-1_Human	1.10730280
97	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.10249611
98	* CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.10122985
99	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.09407056
100	CIITA_25753668_ChIP-Seq_RAJI_Human	1.09347795
101	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.08958145
102	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.08568234
103	MAF_26560356_Chip-Seq_TH1_Human	1.08082671
104	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.07837861
105	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.07607507
106	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.06445925
107	LXR_22292898_ChIP-Seq_THP-1_Human	1.06372594
108	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.05981225
109	UTX_26944678_Chip-Seq_JUKART_Human	1.05965085
110	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.05738492
111	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.05442436
112	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.05340585
113	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.05268466
114	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.04846787
115	* SRF_21415370_ChIP-Seq_HL-1_Mouse	1.03788693
116	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.03515015
117	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02752101
118	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.02129171
119	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.01641011
120	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.01628717
121	XRN2_22483619_ChIP-Seq_HELA_Human	1.00276529
122	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.00200790
123	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.99698301
124	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.98739849
125	* POU5F1_18692474_ChIP-Seq_MESCs_Mouse	0.98704158
126	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.97112290
127	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.96963318
128	FOXP3_21729870_ChIP-Seq_TREG_Human	0.96647207
129	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.96513080
130	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.95004150
131	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.94125660
132	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.93657723
133	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.93566741
134	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.93174731
135	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.90477635
136	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.90283953
137	SOX2_18692474_ChIP-Seq_MESCs_Mouse	0.88546948
138	BCOR_27268052_Chip-Seq_Bcells_Human	0.87388712
139	* CTCF_21964334_Chip-Seq_Bcells_Human	0.85730548
140	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.85149577
141	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.84103378
142	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.84057817
143	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.83816685
144	P68_20966046_ChIP-Seq_HELA_Human	0.82910070
145	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.82876017
146	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.82684065
147	GABP_19822575_ChIP-Seq_HepG2_Human	0.82150766
148	* RACK7_27058665_Chip-Seq_MCF-7_Human	0.81836692
149	NCOR1_26117541_ChIP-Seq_K562_Human	0.81493828
150	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.81059911
151	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.80504405
152	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.79347549
153	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.78996324
154	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.78556224
155	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.78439494
156	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.77605912
157	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.77223088
158	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.77041014
159	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.76854492

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.68587319
2	MP0005360_urolithiasis	6.45925231
3	MP0005085_abnormal_gallbladder_physiolo	4.81779941
4	MP0005365_abnormal_bile_salt	4.80094351
5	MP0008875_abnormal_xenobiotic_pharmacok	4.15411199
6	MP0005666_abnormal_adipose_tissue	4.12879695
7	MP0003806_abnormal_nucleotide_metabolis	3.95198735
8	MP0004185_abnormal_adipocyte_glucose	3.61543906
9	MP0005058_abnormal_lysosome_morphology	3.52899772
10	MP0003011_delayed_dark_adaptation	3.25127966
11	MP0003252_abnormal_bile_duct	2.99212579
12	MP0008260_abnormal_autophagy	2.99017300
13	MP0005375_adipose_tissue_phenotype	2.97103376
14	MP0000751_myopathy	2.88883093
15	MP0005332_abnormal_amino_acid	2.78638083
16	MP0004130_abnormal_muscle_cell	2.58204301
17	MP0002254_reproductive_system_inflammat	2.46889184
18	MP0004264_abnormal_extraembryonic_tissu	2.43304398
19	MP0010329_abnormal_lipoprotein_level	2.42871843
20	MP0002971_abnormal_brown_adipose	2.37871002
21	MP0009840_abnormal_foam_cell	2.24331990
22	MP0009278_abnormal_bone_marrow	2.21759443
23	MP0004019_abnormal_vitamin_homeostasis	2.19368045
24	MP0002653_abnormal_ependyma_morphology	2.14704260
25	MP0005083_abnormal_biliary_tract	2.08553464
26	MP0000003_abnormal_adipose_tissue	2.04695323
27	MP0005319_abnormal_enzyme/_coenzyme	2.01286532
28	MP0001666_abnormal_nutrient_absorption	1.96399061
29	MP0005075_abnormal_melanosome_morpholog	1.93439395
30	MP0003705_abnormal_hypodermis_morpholog	1.88235837
31	MP0000609_abnormal_liver_physiology	1.84987228
32	MP0006035_abnormal_mitochondrial_morpho	1.80793239
33	MP0003195_calcinosis	1.80611724
34	MP0003191_abnormal_cellular_cholesterol	1.73065922
35	MP0003186_abnormal_redox_activity	1.69275738
36	MP0002138_abnormal_hepatobiliary_system	1.64227818
37	MP0002822_catalepsy	1.63390069
38	MP0001545_abnormal_hematopoietic_system	1.63199743
39	MP0005397_hematopoietic_system_phenotyp	1.63199743
40	MP0009643_abnormal_urine_homeostasis	1.59090783
41	MP0006292_abnormal_olfactory_placode	1.57058541
42	MP0006036_abnormal_mitochondrial_physio	1.51119779
43	MP0001661_extended_life_span	1.51054920
44	MP0009384_cardiac_valve_regurgitation	1.49296617
45	MP0004043_abnormal_pH_regulation	1.48859490
46	MP0005535_abnormal_body_temperature	1.46255229
47	MP0009115_abnormal_fat_cell	1.42641918
48	MP0005334_abnormal_fat_pad	1.40561489
49	MP0000343_altered_response_to	1.37600160
50	MP0004957_abnormal_blastocyst_morpholog	1.36984597
51	MP0005584_abnormal_enzyme/coenzyme_acti	1.34645999
52	MP0003959_abnormal_lean_body	1.34314093
53	MP0002118_abnormal_lipid_homeostasis	1.33488390
54	MP0000681_abnormal_thyroid_gland	1.29176138
55	MP0005266_abnormal_metabolism	1.26694277
56	MP0003172_abnormal_lysosome_physiology	1.25993420
57	MP0000598_abnormal_liver_morphology	1.25179212
58	MP0003890_abnormal_embryonic-extraembry	1.24322466
59	MP0005330_cardiomyopathy	1.24103028
60	MP0003646_muscle_fatigue	1.23638168
61	MP0000858_altered_metastatic_potential	1.23440256
62	MP0003122_maternal_imprinting	1.21235200
63	MP0008438_abnormal_cutaneous_collagen	1.16733741
64	MP0000013_abnormal_adipose_tissue	1.16383418
65	MP0002332_abnormal_exercise_endurance	1.16173677
66	MP0001764_abnormal_homeostasis	1.15468011
67	MP0005464_abnormal_platelet_physiology	1.14260407
68	MP0000759_abnormal_skeletal_muscle	1.12159928
69	MP0003279_aneurysm	1.11617637
70	MP0003868_abnormal_feces_composition	1.09501755
71	MP0010030_abnormal_orbit_morphology	1.08678063
72	MP0006138_congestive_heart_failure	1.07523404
73	MP0002933_joint_inflammation	1.06435080
74	MP0008789_abnormal_olfactory_epithelium	1.05742800
75	MP0005636_abnormal_mineral_homeostasis	1.05675212
76	MP0003329_amyloid_beta_deposits	1.04424969
77	MP0003436_decreased_susceptibility_to	1.02342650
78	MP0005452_abnormal_adipose_tissue	1.02233752
79	MP0008057_abnormal_DNA_replication	1.02066978
80	MP0000678_abnormal_parathyroid_gland	0.98827037
81	MP0002396_abnormal_hematopoietic_system	0.98485078
82	MP0000465_gastrointestinal_hemorrhage	0.95452480
83	MP0005501_abnormal_skin_physiology	0.93373102
84	MP0002876_abnormal_thyroid_physiology	0.93109337
85	MP0008961_abnormal_basal_metabolism	0.92720145
86	MP0010352_gastrointestinal_tract_polyps	0.91022866
87	MP0005376_homeostasis/metabolism_phenot	0.90442694
88	MP0004087_abnormal_muscle_fiber	0.90221520
89	MP0010368_abnormal_lymphatic_system	0.89524387
90	MP0005394_taste/olfaction_phenotype	0.88813106
91	MP0005499_abnormal_olfactory_system	0.88813106
92	MP0001881_abnormal_mammary_gland	0.86779599
93	MP0000750_abnormal_muscle_regeneration	0.85702074
94	MP0006082_CNS_inflammation	0.85550472
95	MP0001958_emphysema	0.84743914
96	MP0002132_abnormal_respiratory_system	0.84136627
97	MP0005257_abnormal_intraocular_pressure	0.83475741
98	MP0003656_abnormal_erythrocyte_physiolo	0.80574054
99	MP0002092_abnormal_eye_morphology	0.80487401
100	MP0002970_abnormal_white_adipose	0.79059260
101	MP0002088_abnormal_embryonic_growth/wei	0.78851047
102	MP0001672_abnormal_embryogenesis/_devel	0.78385773
103	MP0005380_embryogenesis_phenotype	0.78385773
104	MP0001293_anophthalmia	0.78256809
105	MP0002136_abnormal_kidney_physiology	0.77946037
106	MP0005508_abnormal_skeleton_morphology	0.77897157
107	MP0000749_muscle_degeneration	0.77753873
108	MP0003984_embryonic_growth_retardation	0.76727492
109	MP0005448_abnormal_energy_balance	0.75610061
110	MP0010630_abnormal_cardiac_muscle	0.74387818
111	MP0008469_abnormal_protein_level	0.74322365
112	MP0004858_abnormal_nervous_system	0.73684678
113	MP0000747_muscle_weakness	0.72893869
114	MP0001756_abnormal_urination	0.72140327
115	MP0000537_abnormal_urethra_morphology	0.72027520
116	MP0005451_abnormal_body_composition	0.71074765
117	MP0009763_increased_sensitivity_to	0.70120903
118	MP0004381_abnormal_hair_follicle	0.69786011
119	MP0005385_cardiovascular_system_phenoty	0.69696467
120	MP0001544_abnormal_cardiovascular_syste	0.69696467
121	MP0009379_abnormal_foot_pigmentation	0.68400662
122	MP0003948_abnormal_gas_homeostasis	0.67729335
123	MP0001849_ear_inflammation	0.67652376
124	MP0008775_abnormal_heart_ventricle	0.67245648
125	MP0000249_abnormal_blood_vessel	0.66883199
126	MP0009642_abnormal_blood_homeostasis	0.65687016
127	MP0002269_muscular_atrophy	0.65686212
128	MP0009764_decreased_sensitivity_to	0.65605326
129	MP0004272_abnormal_basement_membrane	0.64680352
130	MP0009765_abnormal_xenobiotic_induced	0.64140667
131	MP0005647_abnormal_sex_gland	0.63940886
132	MP0000467_abnormal_esophagus_morphology	0.63741310
133	MP0001727_abnormal_embryo_implantation	0.63458506
134	MP0005390_skeleton_phenotype	0.63330568
135	MP0002127_abnormal_cardiovascular_syste	0.61223431
136	MP0002086_abnormal_extraembryonic_tissu	0.61022847
137	MP0005023_abnormal_wound_healing	0.59984242
138	MP0002932_abnormal_joint_morphology	0.58454372
139	MP0000490_abnormal_crypts_of	0.57523456
140	MP0000358_abnormal_cell_content/	0.56294136
141	MP0003077_abnormal_cell_cycle	0.55703771
142	MP0002928_abnormal_bile_duct	0.54832563
143	MP0002249_abnormal_larynx_morphology	0.52863183
144	MP0003183_abnormal_peptide_metabolism	0.49960482
145	MP0004782_abnormal_surfactant_physiolog	0.49330634
146	MP0005670_abnormal_white_adipose	0.49130263
147	MP0000762_abnormal_tongue_morphology	0.48752910
148	MP0000350_abnormal_cell_proliferation	0.48212103
149	MP0002796_impaired_skin_barrier	0.48118097
150	MP0008872_abnormal_physiological_respon	0.47861508
151	MP0008873_increased_physiological_sensi	0.47637096
152	MP0005220_abnormal_exocrine_pancreas	0.46682773
153	MP0003938_abnormal_ear_development	0.46532215
154	MP0001243_abnormal_dermal_layer	0.45516386
155	MP0000313_abnormal_cell_death	0.45203683
156	MP0001730_embryonic_growth_arrest	0.43931790
157	MP0001765_abnormal_ion_homeostasis	0.42867179
158	MP0002078_abnormal_glucose_homeostasis	0.42687644
159	MP0001853_heart_inflammation	0.42014271
160	MP0002135_abnormal_kidney_morphology	0.41855921
161	MP0000377_abnormal_hair_follicle	0.41433619

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.71756646
2	Intrahepatic cholestasis (HP:0001406)	5.19210247
3	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.03083957
4	Hypochromic microcytic anemia (HP:0004840)	5.01725064
5	Hyperglycinuria (HP:0003108)	4.58476720
6	Multiple enchondromatosis (HP:0005701)	4.37738247
7	Deep venous thrombosis (HP:0002625)	4.34910726
8	Gout (HP:0001997)	4.33214919
9	Xanthomatosis (HP:0000991)	4.26677145
10	Hyperammonemia (HP:0001987)	4.19460672
11	Hypobetalipoproteinemia (HP:0003563)	4.17575631
12	Abnormality of glycine metabolism (HP:0010895)	4.08356755
13	Abnormality of serine family amino acid metabolism (HP:0010894)	4.08356755
14	Vertebral compression fractures (HP:0002953)	3.97996259
15	Rhabdomyolysis (HP:0003201)	3.97344112
16	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.77944508
17	Ketosis (HP:0001946)	3.75637096
18	Bilateral microphthalmos (HP:0007633)	3.71256491
19	Abnormality of the intrinsic pathway (HP:0010989)	3.71156473
20	Hepatoblastoma (HP:0002884)	3.67264135
21	Hyperglycinemia (HP:0002154)	3.59130026
22	Prolonged partial thromboplastin time (HP:0003645)	3.57048178
23	Abnormal cartilage morphology (HP:0002763)	3.45727002
24	Oligomenorrhea (HP:0000876)	3.43232090
25	Ragged-red muscle fibers (HP:0003200)	3.41356655
26	Abnormality of pyrimidine metabolism (HP:0004353)	3.40436872
27	Cerebral palsy (HP:0100021)	3.36579210
28	Malnutrition (HP:0004395)	3.33354178
29	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.30441384
30	Hypertriglyceridemia (HP:0002155)	3.29681148
31	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.29622155
32	Increased muscle lipid content (HP:0009058)	3.26310853
33	Cervical subluxation (HP:0003308)	3.24710857
34	Stridor (HP:0010307)	3.16372916
35	Hyperlipoproteinemia (HP:0010980)	3.10922112
36	Abnormality of fatty-acid metabolism (HP:0004359)	3.10826383
37	Abnormality of nucleobase metabolism (HP:0010932)	3.10088909
38	Ketoacidosis (HP:0001993)	3.07661288
39	Protrusio acetabuli (HP:0003179)	3.06182620
40	Growth hormone excess (HP:0000845)	3.06026781
41	Biconcave vertebral bodies (HP:0004586)	3.03556828
42	Exercise-induced myalgia (HP:0003738)	3.03415904
43	Acanthosis nigricans (HP:0000956)	3.03235660
44	Hypolipoproteinemia (HP:0010981)	3.01250057
45	Abnormality of the lower motor neuron (HP:0002366)	3.01092361
46	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.97106936
47	Dicarboxylic aciduria (HP:0003215)	2.97106936
48	Abnormality of purine metabolism (HP:0004352)	2.94914928
49	Delayed CNS myelination (HP:0002188)	2.93050396
50	Myoglobinuria (HP:0002913)	2.91213619
51	Hyperinsulinemic hypoglycemia (HP:0000825)	2.90515766
52	Hypoglycemic coma (HP:0001325)	2.89378156
53	Dysostosis multiplex (HP:0000943)	2.87992851
54	Microvesicular hepatic steatosis (HP:0001414)	2.86281161
55	Reduced antithrombin III activity (HP:0001976)	2.86256802
56	Joint hemorrhage (HP:0005261)	2.85927461
57	Joint stiffness (HP:0001387)	2.82957878
58	Proximal tubulopathy (HP:0000114)	2.81191640
59	Abnormality of methionine metabolism (HP:0010901)	2.80682666
60	Metabolic acidosis (HP:0001942)	2.75997187
61	Cholecystitis (HP:0001082)	2.74689939
62	Abnormal gallbladder physiology (HP:0012438)	2.74689939
63	Increased purine levels (HP:0004368)	2.73828609
64	Hyperuricemia (HP:0002149)	2.73828609
65	Muscle stiffness (HP:0003552)	2.71813888
66	Mucopolysacchariduria (HP:0008155)	2.69356637
67	Urinary glycosaminoglycan excretion (HP:0003541)	2.69356637
68	Lymphangioma (HP:0100764)	2.65525804
69	Abnormality of polysaccharide metabolism (HP:0011012)	2.63996870
70	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.63996870
71	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.63996870
72	Fat malabsorption (HP:0002630)	2.62945366
73	Complement deficiency (HP:0004431)	2.62429889
74	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.61371455
75	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.61092834
76	Hyperbilirubinemia (HP:0002904)	2.59851057
77	Skin nodule (HP:0200036)	2.58579196
78	Increased variability in muscle fiber diameter (HP:0003557)	2.55405933
79	Hypoalphalipoproteinemia (HP:0003233)	2.53874429
80	J-shaped sella turcica (HP:0002680)	2.52918494
81	Rhabdomyosarcoma (HP:0002859)	2.51387240
82	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.50469231
83	Generalized aminoaciduria (HP:0002909)	2.49566999
84	Hypochromic anemia (HP:0001931)	2.46861321
85	Myopathic facies (HP:0002058)	2.45844496
86	Lethargy (HP:0001254)	2.45606983
87	Increased connective tissue (HP:0009025)	2.44291598
88	Spastic diplegia (HP:0001264)	2.43662361
89	Abnormality of skeletal muscle fiber size (HP:0012084)	2.42838654
90	Progressive muscle weakness (HP:0003323)	2.40362490
91	Hypercholesterolemia (HP:0003124)	2.39941792
92	Abnormality of the common coagulation pathway (HP:0010990)	2.39523870
93	Epidermoid cyst (HP:0200040)	2.35816716
94	Systemic lupus erythematosus (HP:0002725)	2.35295929
95	Abnormality of serum amino acid levels (HP:0003112)	2.35163413
96	Distal lower limb muscle weakness (HP:0009053)	2.33711311
97	Neoplasm of striated muscle (HP:0009728)	2.33669675
98	Vomiting (HP:0002013)	2.32824354
99	Irritability (HP:0000737)	2.32115817
100	Broad distal phalanx of finger (HP:0009836)	2.30960930
101	Hepatocellular necrosis (HP:0001404)	2.29599282
102	Hepatosplenomegaly (HP:0001433)	2.28471728
103	Back pain (HP:0003418)	2.28319240
104	Hemorrhage of the eye (HP:0011885)	2.27648240
105	Partial duplication of thumb phalanx (HP:0009944)	2.23477328
106	Hepatocellular carcinoma (HP:0001402)	2.20383873
107	Hepatic necrosis (HP:0002605)	2.20128685
108	Colitis (HP:0002583)	2.18049212
109	Ependymoma (HP:0002888)	2.17126429
110	Easy fatigability (HP:0003388)	2.13691248
111	Abnormality of complement system (HP:0005339)	2.13555750
112	Rib fusion (HP:0000902)	2.11951211
113	Gastrointestinal dysmotility (HP:0002579)	2.11932372
114	Abnormality of the Achilles tendon (HP:0005109)	2.08835035
115	Abnormal enzyme/coenzyme activity (HP:0012379)	2.07635350
116	Asymmetric septal hypertrophy (HP:0001670)	2.07605602
117	Reticulocytosis (HP:0001923)	2.07128168
118	Type I transferrin isoform profile (HP:0003642)	2.05735696
119	Hypertensive crisis (HP:0100735)	2.04799629
120	Testicular atrophy (HP:0000029)	2.04311515
121	Abnormality of transition element cation homeostasis (HP:0011030)	2.04242712
122	Enlarged kidneys (HP:0000105)	2.02902543
123	Distal lower limb amyotrophy (HP:0008944)	2.00048790
124	Thoracic kyphosis (HP:0002942)	1.99977315
125	Abnormality of iron homeostasis (HP:0011031)	1.99395130
126	Increased intramyocellular lipid droplets (HP:0012240)	1.98955694
127	3-Methylglutaconic aciduria (HP:0003535)	1.98124086
128	Insulin resistance (HP:0000855)	1.97514358
129	Increased serum ferritin (HP:0003281)	1.96559559
130	Difficulty climbing stairs (HP:0003551)	1.96391354
131	Partial duplication of the phalanx of hand (HP:0009999)	1.93016323
132	Agammaglobulinemia (HP:0004432)	1.92578953
133	Late onset (HP:0003584)	1.92007300
134	Abnormality of glycolysis (HP:0004366)	1.91981607
135	Increased serum pyruvate (HP:0003542)	1.91981607
136	Abnormality of alkaline phosphatase activity (HP:0004379)	1.91391901
137	Prolonged neonatal jaundice (HP:0006579)	1.90975926
138	Neck muscle weakness (HP:0000467)	1.89309969
139	Opisthotonus (HP:0002179)	1.88929719
140	Steatorrhea (HP:0002570)	1.87983942
141	Rickets (HP:0002748)	1.87283965
142	Seborrheic dermatitis (HP:0001051)	1.87213184
143	Bile duct proliferation (HP:0001408)	1.86882867
144	Abnormal biliary tract physiology (HP:0012439)	1.86882867
145	Alkalosis (HP:0001948)	1.84538965
146	Pseudobulbar signs (HP:0002200)	1.84306833
147	Abnormality of the thoracic spine (HP:0100711)	1.83809813
148	Microretrognathia (HP:0000308)	1.83713656
149	Vaginal fistula (HP:0004320)	1.83275813
150	Glycosuria (HP:0003076)	1.82784541
151	Abnormality of urine glucose concentration (HP:0011016)	1.82784541
152	Cholelithiasis (HP:0001081)	1.82197367
153	Neonatal onset (HP:0003623)	1.82110397
154	Short nail (HP:0001799)	1.81793735
155	Interstitial pulmonary disease (HP:0006530)	1.80093467
156	Tetraplegia (HP:0002445)	1.79527510
157	Cellulitis (HP:0100658)	1.79386435
158	Spinal rigidity (HP:0003306)	1.78949495
159	Atelectasis (HP:0100750)	1.78634624
160	Nuclear cataract (HP:0100018)	1.77961089
161	Conjugated hyperbilirubinemia (HP:0002908)	1.76011773
162	Nausea (HP:0002018)	1.75650234
163	Premature rupture of membranes (HP:0001788)	1.75136326
164	Polygenic inheritance (HP:0010982)	1.75033752
165	Distal upper limb amyotrophy (HP:0007149)	1.73825149
166	Upper limb amyotrophy (HP:0009129)	1.73825149
167	Abnormality of the salivary glands (HP:0010286)	1.73582051
168	Mesangial abnormality (HP:0001966)	1.73331043
169	Exercise intolerance (HP:0003546)	1.71855314
170	Elevated alkaline phosphatase (HP:0003155)	1.71265655
171	Pancreatic islet-cell hyperplasia (HP:0004510)	1.70691134
172	Bulbar palsy (HP:0001283)	1.69579328
173	Spastic paraparesis (HP:0002313)	1.67187514
174	Abnormality of glycolipid metabolism (HP:0010969)	1.66553449
175	Abnormality of liposaccharide metabolism (HP:0010968)	1.66553449
176	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.66553449
177	Progressive neurologic deterioration (HP:0002344)	1.65184503
178	Achilles tendon contracture (HP:0001771)	1.64720243

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	5.62103367
2	CDK12	5.59717817
3	BCKDK	4.28172388
4	GRK6	4.16173106
5	GRK5	3.31633577
6	TESK1	3.02622399
7	CSF1R	2.79084083
8	PIM2	2.67027771
9	VRK2	2.55239543
10	TGFBR2	2.54499363
11	GRK1	2.50753286
12	TESK2	2.44351721
13	ARAF	2.17655295
14	ADRBK2	2.16684302
15	TTK	2.08813202
16	MAP3K10	1.97847690
17	FLT3	1.96769339
18	BUB1	1.90222560
19	STK10	1.86759254
20	MATK	1.82314621
21	SMG1	1.79112938
22	SIK1	1.72806243
23	TBK1	1.69284011
24	MAPK7	1.63254243
25	NME2	1.61876983
26	CDK7	1.51172658
27	PAK4	1.43724135
28	PRPF4B	1.40815957
29	MAP2K6	1.37781748
30	SCYL2	1.37261074
31	MOS	1.34040500
32	GRK7	1.31485840
33	TYRO3	1.31102765
34	EPHB2	1.30698949
35	PRKG2	1.30341574
36	MAP2K3	1.28864953
37	FGFR4	1.27855557
38	MAP2K4	1.27008463
39	PKN2	1.24782456
40	CDK19	1.22736880
41	MAP3K7	1.21204867
42	PRKD2	1.20515609
43	NEK1	1.17523067
44	CAMK4	1.09949619
45	WNK3	1.05816365
46	EPHA2	1.04241854
47	WEE1	1.04201092
48	TRIB3	1.03361820
49	TNK2	1.00801818
50	WNK1	1.00127530
51	EPHB1	0.98755873
52	FGFR3	0.98295606
53	ACVR1B	0.97671602
54	DAPK1	0.97235642
55	TIE1	0.96494651
56	MAP3K13	0.95695626
57	CDK4	0.93136001
58	ICK	0.92587262
59	NEK2	0.89474058
60	LIMK1	0.89361521
61	TTN	0.85525654
62	MAP3K6	0.83824480
63	PLK1	0.83798514
64	PTK6	0.83525173
65	RIPK1	0.80271677
66	BMX	0.78986978
67	FES	0.76816701
68	MAPK11	0.76349519
69	AKT2	0.76181159
70	JAK3	0.74888455
71	DDR2	0.73525433
72	KDR	0.72998595
73	RPS6KB2	0.72482884
74	MAPK12	0.71589211
75	CSK	0.71458774
76	IRAK3	0.69871175
77	MAP4K2	0.69092295
78	DYRK3	0.68447324
79	MAP4K1	0.68051936
80	ADRBK1	0.66383117
81	PDGFRA	0.65905385
82	DAPK3	0.65873739
83	PRKD3	0.65235122
84	CHEK2	0.65157078
85	KIT	0.63494876
86	MYLK	0.61856032
87	BTK	0.61115914
88	RPS6KL1	0.60861648
89	RPS6KC1	0.60861648
90	TGFBR1	0.60531281
91	WNK4	0.60446863
92	MAPKAPK3	0.60111441
93	RPS6KA2	0.59787228
94	DYRK1B	0.59373948
95	MTOR	0.59176181
96	CDK9	0.58949515
97	PDPK1	0.57614488
98	LRRK2	0.55563228
99	MAP3K3	0.55209562
100	ILK	0.54505730
101	MAPK4	0.54495775
102	MAP2K2	0.52330564
103	ZAP70	0.50328775
104	AURKB	0.48532716
105	MARK2	0.48223795
106	ERBB2	0.48047054
107	HIPK2	0.47764013
108	PRKAA2	0.46404780
109	NTRK1	0.45867533
110	MAP3K11	0.45261660
111	TAOK2	0.44706281
112	PRKD1	0.44456897
113	MAP3K1	0.44316198
114	ABL2	0.43068444
115	PTK2	0.42188155
116	TYK2	0.41966211
117	PAK1	0.40357743
118	ERBB4	0.40184772
119	STK16	0.39774454
120	AURKA	0.39638489
121	EEF2K	0.39631909
122	RPS6KA6	0.39587595
123	PDK4	0.39322447
124	PDK3	0.39322447
125	CHEK1	0.38919599
126	BRAF	0.38559008
127	RAF1	0.38421912
128	MAP3K8	0.38362209
129	NME1	0.37970459
130	CSNK1G3	0.36974142
131	PRKCI	0.36746847
132	ITK	0.36422256
133	JAK2	0.35735937
134	BLK	0.35401130
135	IGF1R	0.35274767
136	CAMK2G	0.35247341
137	MAPK15	0.35003697
138	SRC	0.34901910
139	IKBKB	0.34655893
140	MAPK3	0.33187295
141	MUSK	0.32872510
142	CDK8	0.32500609
143	RPS6KA4	0.32036208
144	PRKACG	0.31879373
145	MST1R	0.31314870
146	STK4	0.30573418
147	GSK3A	0.29944493
148	PIM1	0.28430846
149	OXSR1	0.28358977
150	AKT3	0.27267556
151	EIF2AK2	0.26178829
152	PRKCD	0.26128277
153	PRKAA1	0.25119734
154	STK38L	0.24550553
155	CDK2	0.24337828

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.48571559
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.20711069
3	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.88672153
4	Tryptophan metabolism_Homo sapiens_hsa00380	2.62259581
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.62217583
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.61935058
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.61773801
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.50732210
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.35322043
10	Arginine biosynthesis_Homo sapiens_hsa00220	2.33044532
11	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.32875105
12	Fatty acid degradation_Homo sapiens_hsa00071	2.31755331
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.29386576
14	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.02908805
15	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.99372634
16	Chemical carcinogenesis_Homo sapiens_hsa05204	1.98553122
17	Complement and coagulation cascades_Homo sapiens_hsa04610	1.97392111
18	Peroxisome_Homo sapiens_hsa04146	1.95216186
19	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.87480605
20	Butanoate metabolism_Homo sapiens_hsa00650	1.85934419
21	Folate biosynthesis_Homo sapiens_hsa00790	1.85595007
22	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.80781050
23	Propanoate metabolism_Homo sapiens_hsa00640	1.80267789
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.79119605
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.76198006
26	One carbon pool by folate_Homo sapiens_hsa00670	1.55968756
27	PPAR signaling pathway_Homo sapiens_hsa03320	1.55801864
28	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.55225194
29	Caffeine metabolism_Homo sapiens_hsa00232	1.54367932
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.54253405
31	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.53637864
32	Carbon metabolism_Homo sapiens_hsa01200	1.52678407
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.52058266
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.51349120
35	Sulfur relay system_Homo sapiens_hsa04122	1.51280091
36	Retinol metabolism_Homo sapiens_hsa00830	1.47977984
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.47225032
38	Fatty acid metabolism_Homo sapiens_hsa01212	1.46538751
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.44925242
40	Histidine metabolism_Homo sapiens_hsa00340	1.44626101
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.44325130
42	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.44188998
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.28829379
44	Bile secretion_Homo sapiens_hsa04976	1.23963224
45	Galactose metabolism_Homo sapiens_hsa00052	1.22261140
46	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.21961522
47	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.20157016
48	Phenylalanine metabolism_Homo sapiens_hsa00360	1.14051899
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.12850485
50	Pentose phosphate pathway_Homo sapiens_hsa00030	1.11477159
51	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.10698315
52	Tyrosine metabolism_Homo sapiens_hsa00350	1.07886598
53	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.06241318
54	Glutathione metabolism_Homo sapiens_hsa00480	1.03098250
55	Notch signaling pathway_Homo sapiens_hsa04330	1.02796918
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.02108956
57	Sulfur metabolism_Homo sapiens_hsa00920	0.99982106
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.98675863
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98365617
60	Acute myeloid leukemia_Homo sapiens_hsa05221	0.90699953
61	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.88021418
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.87935917
63	ABC transporters_Homo sapiens_hsa02010	0.84892276
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83687788
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83600178
66	Lysine degradation_Homo sapiens_hsa00310	0.83340150
67	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.80953583
68	Fatty acid elongation_Homo sapiens_hsa00062	0.80153898
69	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.79587100
70	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.79397895
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79197318
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.77790243
73	Ribosome_Homo sapiens_hsa03010	0.74552239
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70920557
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67485602
76	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65960287
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.65773377
78	DNA replication_Homo sapiens_hsa03030	0.65104747
79	Lysosome_Homo sapiens_hsa04142	0.63888392
80	Insulin signaling pathway_Homo sapiens_hsa04910	0.63833817
81	Metabolic pathways_Homo sapiens_hsa01100	0.63021679
82	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.60801263
83	Linoleic acid metabolism_Homo sapiens_hsa00591	0.60111927
84	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57405879
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.49931968
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43961482
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41091241
88	Mismatch repair_Homo sapiens_hsa03430	0.34690217
89	Parkinsons disease_Homo sapiens_hsa05012	0.34467098
90	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.33548475
91	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.31530963
92	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.29173441
93	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.28933190
94	Primary immunodeficiency_Homo sapiens_hsa05340	0.26807217
95	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.26724480
96	Shigellosis_Homo sapiens_hsa05131	0.26435984
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.23093405
98	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.22451971
99	Base excision repair_Homo sapiens_hsa03410	0.22410642
100	Other glycan degradation_Homo sapiens_hsa00511	0.21828759
101	Hepatitis C_Homo sapiens_hsa05160	0.19570217
102	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.18990908
103	VEGF signaling pathway_Homo sapiens_hsa04370	0.18636564
104	ECM-receptor interaction_Homo sapiens_hsa04512	0.18634193
105	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.17899687
106	Thyroid cancer_Homo sapiens_hsa05216	0.17757582
107	Glucagon signaling pathway_Homo sapiens_hsa04922	0.17693953
108	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.17646014
109	Vibrio cholerae infection_Homo sapiens_hsa05110	0.17212695
110	RNA transport_Homo sapiens_hsa03013	0.15468820
111	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.14803143
112	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.14578913
113	Oxidative phosphorylation_Homo sapiens_hsa00190	0.14399101
114	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.13801173
115	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.11993954
116	Bladder cancer_Homo sapiens_hsa05219	0.11799594
117	Salmonella infection_Homo sapiens_hsa05132	0.11684926
118	Renin-angiotensin system_Homo sapiens_hsa04614	0.11472731
119	Insulin resistance_Homo sapiens_hsa04931	0.09233025
120	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.08875611
121	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.08502086
122	Protein digestion and absorption_Homo sapiens_hsa04974	0.07207679
123	AMPK signaling pathway_Homo sapiens_hsa04152	0.05322062
124	Homologous recombination_Homo sapiens_hsa03440	0.02898716
125	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	-0.0464854
126	Fatty acid biosynthesis_Homo sapiens_hsa00061	-0.0429268
127	Spliceosome_Homo sapiens_hsa03040	-0.0348578
128	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0302410

SCRN2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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