SCRN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.97755586
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.97755586
3L-phenylalanine metabolic process (GO:0006558)6.53767743
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.53767743
5aromatic amino acid family catabolic process (GO:0009074)6.04881450
6indole-containing compound catabolic process (GO:0042436)5.23830476
7indolalkylamine catabolic process (GO:0046218)5.23830476
8tryptophan catabolic process (GO:0006569)5.23830476
9bile acid biosynthetic process (GO:0006699)5.15424059
10kynurenine metabolic process (GO:0070189)5.09313214
11nerve growth factor signaling pathway (GO:0038180)5.02331000
12tryptophan metabolic process (GO:0006568)5.01632497
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.97475059
14glyoxylate metabolic process (GO:0046487)4.93980486
15cysteine metabolic process (GO:0006534)4.89321012
16negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.86860147
17lysine metabolic process (GO:0006553)4.82457031
18lysine catabolic process (GO:0006554)4.82457031
19alpha-linolenic acid metabolic process (GO:0036109)4.71991652
20regulation of glucokinase activity (GO:0033131)4.66660857
21regulation of hexokinase activity (GO:1903299)4.66660857
22negative regulation of neurotransmitter transport (GO:0051589)4.65385500
23high-density lipoprotein particle remodeling (GO:0034375)4.53190010
24protein carboxylation (GO:0018214)4.52551089
25peptidyl-glutamic acid carboxylation (GO:0017187)4.52551089
26sulfur amino acid catabolic process (GO:0000098)4.46578953
27aromatic amino acid family metabolic process (GO:0009072)4.42824880
28regulation of protein activation cascade (GO:2000257)4.42674637
29urea metabolic process (GO:0019627)4.41872321
30urea cycle (GO:0000050)4.41872321
31negative regulation of neurotransmitter secretion (GO:0046929)4.40367311
32tyrosine metabolic process (GO:0006570)4.38431764
33complement activation, alternative pathway (GO:0006957)4.37724847
34response to pheromone (GO:0019236)4.36899154
35regulation of fibrinolysis (GO:0051917)4.34685545
36negative regulation of fibrinolysis (GO:0051918)4.33335437
37bile acid metabolic process (GO:0008206)4.33008522
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.31797636
39cellular ketone body metabolic process (GO:0046950)4.30829148
40alpha-amino acid catabolic process (GO:1901606)4.21621341
41coenzyme catabolic process (GO:0009109)4.19844046
42regulation of complement activation (GO:0030449)4.16436568
43serine family amino acid catabolic process (GO:0009071)4.13192730
44glutamate metabolic process (GO:0006536)4.10455679
45nitrogen cycle metabolic process (GO:0071941)4.07617742
46homocysteine metabolic process (GO:0050667)4.05809362
47short-chain fatty acid metabolic process (GO:0046459)4.05517613
48amino-acid betaine metabolic process (GO:0006577)4.02829562
49aspartate family amino acid catabolic process (GO:0009068)3.98286405
50positive regulation of mitochondrial fission (GO:0090141)3.94459666
51cellular amino acid catabolic process (GO:0009063)3.94300162
52reverse cholesterol transport (GO:0043691)3.92371288
53regulation of triglyceride catabolic process (GO:0010896)3.90119522
54indolalkylamine metabolic process (GO:0006586)3.89697886
55triglyceride homeostasis (GO:0070328)3.89053727
56acylglycerol homeostasis (GO:0055090)3.89053727
57acetyl-CoA metabolic process (GO:0006084)3.85304661
58regulation of cholesterol esterification (GO:0010872)3.84018507
59protein-lipid complex remodeling (GO:0034368)3.82458149
60macromolecular complex remodeling (GO:0034367)3.82458149
61plasma lipoprotein particle remodeling (GO:0034369)3.82458149
62ethanol oxidation (GO:0006069)3.81481747
63dicarboxylic acid biosynthetic process (GO:0043650)3.80166012
64cellular biogenic amine catabolic process (GO:0042402)3.72698929
65amine catabolic process (GO:0009310)3.72698929
66ketone body metabolic process (GO:1902224)3.72264761
67cellular modified amino acid catabolic process (GO:0042219)3.69432151
68plasma lipoprotein particle clearance (GO:0034381)3.64325393
69drug catabolic process (GO:0042737)3.63586696
70startle response (GO:0001964)3.63392617
71dopamine transport (GO:0015872)3.61603405
72cofactor catabolic process (GO:0051187)3.61046536
73bile acid and bile salt transport (GO:0015721)3.56042100
74organic acid catabolic process (GO:0016054)3.52624756
75carboxylic acid catabolic process (GO:0046395)3.52624756
76cellular glucuronidation (GO:0052695)3.51914357
77phospholipid efflux (GO:0033700)3.51892694
78cholesterol efflux (GO:0033344)3.50207271
79benzene-containing compound metabolic process (GO:0042537)3.48069075
80imidazole-containing compound metabolic process (GO:0052803)3.46960719
81aldehyde catabolic process (GO:0046185)3.46511387
82neural tube formation (GO:0001841)3.44915924
83drug transmembrane transport (GO:0006855)3.44549031
84fatty acid beta-oxidation (GO:0006635)3.43044510
85fatty acid oxidation (GO:0019395)3.42205265
86monocarboxylic acid catabolic process (GO:0072329)3.41410309
87regulation of bile acid biosynthetic process (GO:0070857)3.37667168
88fatty acid catabolic process (GO:0009062)3.36954583
892-oxoglutarate metabolic process (GO:0006103)3.36792159
90lipid oxidation (GO:0034440)3.36252106
91positive regulation of vasculogenesis (GO:2001214)3.35958939
92protein localization to cilium (GO:0061512)3.35780954
93negative regulation of sterol transport (GO:0032372)3.35414130
94negative regulation of cholesterol transport (GO:0032375)3.35414130
95serine family amino acid metabolic process (GO:0009069)3.34856640
96establishment of protein localization to Golgi (GO:0072600)3.30551829
97arginine metabolic process (GO:0006525)3.28795227
98nonmotile primary cilium assembly (GO:0035058)3.28530841
99fibrinolysis (GO:0042730)3.28367228
100exogenous drug catabolic process (GO:0042738)3.24208281
101heme transport (GO:0015886)3.21146711
102glucuronate metabolic process (GO:0019585)3.18107748
103uronic acid metabolic process (GO:0006063)3.18107748
104negative regulation of lipase activity (GO:0060192)3.17797746
105presynaptic membrane assembly (GO:0097105)3.17758899
106very long-chain fatty acid metabolic process (GO:0000038)3.17636587
107very-low-density lipoprotein particle assembly (GO:0034379)3.16706443
108pyrimidine nucleobase catabolic process (GO:0006208)3.16608254
109opsonization (GO:0008228)3.15915588
110urate metabolic process (GO:0046415)3.15753288
111branched-chain amino acid catabolic process (GO:0009083)3.13672078
112low-density lipoprotein particle remodeling (GO:0034374)3.13089474
113protein targeting to Golgi (GO:0000042)3.12392953
114cytolysis (GO:0019835)3.12340450
115glycine metabolic process (GO:0006544)3.11574429
116blood coagulation, intrinsic pathway (GO:0007597)3.11138045
117regulation of synaptic vesicle transport (GO:1902803)3.10998782
118plasma lipoprotein particle assembly (GO:0034377)3.10988618
119regulation of cholesterol metabolic process (GO:0090181)3.10649099
120regulation of synaptic vesicle exocytosis (GO:2000300)3.02698001
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.99882945
122protein prenylation (GO:0018342)2.99264092
123prenylation (GO:0097354)2.99264092
124intraciliary transport (GO:0042073)2.89283915
125retrograde transport, vesicle recycling within Golgi (GO:0000301)2.86206712
126presynaptic membrane organization (GO:0097090)2.85654385
127cilium morphogenesis (GO:0060271)2.83966467
128platelet dense granule organization (GO:0060155)2.80761006
129C4-dicarboxylate transport (GO:0015740)2.73952002
130nucleobase catabolic process (GO:0046113)2.72980525
131cilium assembly (GO:0042384)2.72310239
132cilium organization (GO:0044782)2.71050819
133photoreceptor cell maintenance (GO:0045494)2.67953284
134neuronal action potential propagation (GO:0019227)2.67076173
135regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.66526410
136epithelial cilium movement (GO:0003351)2.66294437
137axoneme assembly (GO:0035082)2.66042907
138regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.66019016
139regulation of mitochondrial fission (GO:0090140)2.65749471
140rRNA methylation (GO:0031167)2.65575436
141inner ear receptor stereocilium organization (GO:0060122)2.65479370
142mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.62226571
143positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.62226571
144postsynaptic membrane organization (GO:0001941)2.61477675
145auditory receptor cell stereocilium organization (GO:0060088)2.60081121
146positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.59579398
147regulation of establishment of cell polarity (GO:2000114)2.56581923
148righting reflex (GO:0060013)2.56312662
149reflex (GO:0060004)2.55481145
150inositol phosphate catabolic process (GO:0071545)2.55382729
151glycosphingolipid biosynthetic process (GO:0006688)2.55107944
152positive regulation of glycolytic process (GO:0045821)2.53828797
153protein K6-linked ubiquitination (GO:0085020)2.53078266
154L-fucose catabolic process (GO:0042355)2.52947289
155fucose catabolic process (GO:0019317)2.52947289
156L-fucose metabolic process (GO:0042354)2.52947289
157regulation of cell communication by electrical coupling (GO:0010649)2.52466908
158calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51540459
159regulation of sarcomere organization (GO:0060297)2.51508963
160neurotransmitter-gated ion channel clustering (GO:0072578)2.50664624
161neuron cell-cell adhesion (GO:0007158)2.48915914
162regulation of relaxation of muscle (GO:1901077)2.48599605
163regulation of vasculogenesis (GO:2001212)2.48578011
164intra-Golgi vesicle-mediated transport (GO:0006891)2.46710187
165neurotransmitter uptake (GO:0001504)2.46285141
166protein localization to Golgi apparatus (GO:0034067)2.45616635
167cellular component assembly involved in morphogenesis (GO:0010927)2.45483248
168anterograde synaptic vesicle transport (GO:0048490)2.43922361
169inositol metabolic process (GO:0006020)2.42074007
170regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.41286099
171auditory behavior (GO:0031223)2.37986683
172monoubiquitinated protein deubiquitination (GO:0035520)2.37373827
173polyol catabolic process (GO:0046174)2.36573930
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35903181
175gamma-aminobutyric acid transport (GO:0015812)2.34333517
176protein K11-linked deubiquitination (GO:0035871)2.32435398
177relaxation of smooth muscle (GO:0044557)2.32262430
178Rap protein signal transduction (GO:0032486)2.32034089
179synaptic transmission, glutamatergic (GO:0035249)2.31286290
180acrosome assembly (GO:0001675)2.31280305
181calcium ion import (GO:0070509)2.29836082
182catecholamine transport (GO:0051937)2.29612181
183L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.29284703
184microtubule anchoring (GO:0034453)2.29002695
185phosphorylated carbohydrate dephosphorylation (GO:0046838)2.28748236
186inositol phosphate dephosphorylation (GO:0046855)2.28748236
187regulation of respiratory system process (GO:0044065)2.28720688
188regulation of male gonad development (GO:2000018)2.26957744
189regulation of neurotransmitter transport (GO:0051588)2.25784766
190negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.25556028
191DNA double-strand break processing (GO:0000729)2.25370518
192detection of light stimulus involved in sensory perception (GO:0050962)2.25153977
193detection of light stimulus involved in visual perception (GO:0050908)2.25153977
194synapse assembly (GO:0007416)2.24911630
195regulation of acyl-CoA biosynthetic process (GO:0050812)2.24805808
196regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.24596112
197positive regulation of male gonad development (GO:2000020)2.24025404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.90948201
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.23319048
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.16838095
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.06461253
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.97680992
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.06355981
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.58346166
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.58151842
9IGF1R_20145208_ChIP-Seq_DFB_Human3.36607223
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.24302536
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.74849991
12ZNF274_21170338_ChIP-Seq_K562_Hela2.64260158
13FUS_26573619_Chip-Seq_HEK293_Human2.38922303
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.28678058
15EWS_26573619_Chip-Seq_HEK293_Human2.22967611
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.17390424
17GBX2_23144817_ChIP-Seq_PC3_Human2.06913626
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95769737
19ER_23166858_ChIP-Seq_MCF-7_Human1.94323400
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82332152
21HTT_18923047_ChIP-ChIP_STHdh_Human1.75113350
22TAF15_26573619_Chip-Seq_HEK293_Human1.71815269
23GATA1_22025678_ChIP-Seq_K562_Human1.67189408
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.64192107
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60599523
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55380272
27TCF4_23295773_ChIP-Seq_U87_Human1.55321940
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49170409
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48542047
30NANOG_18555785_Chip-Seq_ESCs_Mouse1.45976742
31* FOXA2_19822575_ChIP-Seq_HepG2_Human1.45645141
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42817511
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37425015
34* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37290775
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37209134
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36797228
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36379035
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36379035
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.32259525
40P53_22387025_ChIP-Seq_ESCs_Mouse1.31715102
41* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31338302
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31313771
43FLI1_21867929_ChIP-Seq_TH2_Mouse1.30684423
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.29627988
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.29314212
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27674773
47* RUNX2_22187159_ChIP-Seq_PCA_Human1.25967475
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24938930
49TCF4_22108803_ChIP-Seq_LS180_Human1.23786369
50RNF2_27304074_Chip-Seq_NSC_Mouse1.22445710
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21679578
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.21092216
53E2F1_18555785_Chip-Seq_ESCs_Mouse1.20996643
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.20084968
55CMYC_18555785_Chip-Seq_ESCs_Mouse1.17248658
56IRF1_19129219_ChIP-ChIP_H3396_Human1.16708898
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15937340
58OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15778758
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15359841
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15359841
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12780648
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11490600
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10946025
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09503145
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08635660
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08520618
67CDX2_22108803_ChIP-Seq_LS180_Human1.08456546
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.06864739
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06531158
70JUN_21703547_ChIP-Seq_K562_Human1.06385013
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05640983
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.04481008
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04340505
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.04148000
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03587594
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03517020
77P300_18555785_Chip-Seq_ESCs_Mouse1.03201515
78* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03035018
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02635563
80ELK1_19687146_ChIP-ChIP_HELA_Human1.02315062
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02171691
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02064460
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01203691
84TP53_18474530_ChIP-ChIP_U2OS_Human1.01135634
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00669519
86CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99267520
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98958871
88VDR_22108803_ChIP-Seq_LS180_Human0.94707438
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94584973
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92989367
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92206781
92P300_19829295_ChIP-Seq_ESCs_Human0.91998904
93MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91555848
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89011753
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88881457
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88729259
97SMAD4_21799915_ChIP-Seq_A2780_Human0.88580162
98EZH2_22144423_ChIP-Seq_EOC_Human0.88080357
99NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87694240
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86063938
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85786377
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85638689
103CLOCK_20551151_ChIP-Seq_293T_Human0.83538300
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83215773
105* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82593096
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81365989
107CBP_21632823_ChIP-Seq_H3396_Human0.79951900
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79674409
109AR_21572438_ChIP-Seq_LNCaP_Human0.78867654
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78669364
111REST_21632747_ChIP-Seq_MESCs_Mouse0.78631146
112STAT3_23295773_ChIP-Seq_U87_Human0.77508227
113SOX2_21211035_ChIP-Seq_LN229_Gbm0.77168613
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.77154128
115REST_18959480_ChIP-ChIP_MESCs_Mouse0.76859620
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76516114
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.75607651
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75265106
119CBP_20019798_ChIP-Seq_JUKART_Human0.75265106
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.74807356
121BCAT_22108803_ChIP-Seq_LS180_Human0.74554902
122SOX2_27498859_Chip-Seq_STOMACH_Mouse0.73998900
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73807388
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73759507
125SOX2_19829295_ChIP-Seq_ESCs_Human0.72790112
126NANOG_19829295_ChIP-Seq_ESCs_Human0.72790112
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.71632533
128AR_25329375_ChIP-Seq_VCAP_Human0.71316000
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.71062486
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.70270867
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.70015776
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69447320
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.68986675
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.68790121
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.68179558
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.66815109
137NCOR_22424771_ChIP-Seq_293T_Human0.66434299
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66259022
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.66120959
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.65498260
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.65251656
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.65143246
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.64827334
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.64748974
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64636635
146SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64543627
147SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.64330753
148RUNX1_27457419_Chip-Seq_LIVER_Mouse0.63881208
149DROSHA_22980978_ChIP-Seq_HELA_Human0.62981740
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.62893331
151CRX_20693478_ChIP-Seq_RETINA_Mouse0.62758967
152RNF2_18974828_ChIP-Seq_MESCs_Mouse0.62669127
153EZH2_18974828_ChIP-Seq_MESCs_Mouse0.62669127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.48690504
2MP0005360_urolithiasis6.47186319
3MP0005085_abnormal_gallbladder_physiolo5.64490862
4MP0005365_abnormal_bile_salt5.17677132
5MP0008875_abnormal_xenobiotic_pharmacok4.42357740
6MP0003806_abnormal_nucleotide_metabolis4.15330163
7MP0003195_calcinosis3.42865733
8MP0003252_abnormal_bile_duct3.33716359
9MP0010329_abnormal_lipoprotein_level2.92189695
10MP0005083_abnormal_biliary_tract2.80679693
11MP0005332_abnormal_amino_acid2.66958365
12MP0002102_abnormal_ear_morphology2.36809166
13MP0009840_abnormal_foam_cell2.34253008
14MP0001984_abnormal_olfaction2.27591007
15MP0001666_abnormal_nutrient_absorption2.23694387
16MP0000569_abnormal_digit_pigmentation2.22016609
17MP0005645_abnormal_hypothalamus_physiol1.99695975
18MP0002118_abnormal_lipid_homeostasis1.96890929
19MP0008877_abnormal_DNA_methylation1.96213841
20MP0004084_abnormal_cardiac_muscle1.92851118
21MP0006072_abnormal_retinal_apoptosis1.91343151
22MP0001529_abnormal_vocalization1.89828972
23MP0002837_dystrophic_cardiac_calcinosis1.88775269
24MP0003191_abnormal_cellular_cholesterol1.80584991
25MP0005253_abnormal_eye_physiology1.80442617
26MP0003122_maternal_imprinting1.78857529
27MP0004019_abnormal_vitamin_homeostasis1.77427535
28MP0002638_abnormal_pupillary_reflex1.73375327
29MP0003656_abnormal_erythrocyte_physiolo1.70822758
30MP0002138_abnormal_hepatobiliary_system1.69916164
31MP0005551_abnormal_eye_electrophysiolog1.67733358
32MP0000609_abnormal_liver_physiology1.66985786
33MP0003868_abnormal_feces_composition1.61573735
34MP0003635_abnormal_synaptic_transmissio1.60730890
35MP0005584_abnormal_enzyme/coenzyme_acti1.58381152
36MP0004885_abnormal_endolymph1.56778262
37MP0005319_abnormal_enzyme/_coenzyme1.55585090
38MP0003787_abnormal_imprinting1.51806368
39MP0001764_abnormal_homeostasis1.51393150
40MP0009697_abnormal_copulation1.47648159
41MP0005646_abnormal_pituitary_gland1.45969091
42MP0002822_catalepsy1.45855789
43MP0006036_abnormal_mitochondrial_physio1.45309863
44MP0004924_abnormal_behavior1.41875517
45MP0005386_behavior/neurological_phenoty1.41875517
46MP0005187_abnormal_penis_morphology1.40218584
47MP0002734_abnormal_mechanical_nocicepti1.39649106
48MP0002572_abnormal_emotion/affect_behav1.38920413
49MP0004147_increased_porphyrin_level1.35718851
50MP0004043_abnormal_pH_regulation1.35071276
51MP0003121_genomic_imprinting1.34365826
52MP0002909_abnormal_adrenal_gland1.34222001
53MP0000778_abnormal_nervous_system1.34062255
54MP0000751_myopathy1.33307714
55MP0004133_heterotaxia1.28519542
56MP0002063_abnormal_learning/memory/cond1.25451532
57MP0002234_abnormal_pharynx_morphology1.24925650
58MP0003690_abnormal_glial_cell1.23924011
59MP0009643_abnormal_urine_homeostasis1.20128367
60MP0008057_abnormal_DNA_replication1.20083824
61MP0005379_endocrine/exocrine_gland_phen1.19874722
62MP0010386_abnormal_urinary_bladder1.18980294
63MP0005535_abnormal_body_temperature1.18831040
64MP0004130_abnormal_muscle_cell1.18802908
65MP0003329_amyloid_beta_deposits1.18780397
66MP0005670_abnormal_white_adipose1.18705229
67MP0008058_abnormal_DNA_repair1.18062706
68MP0004484_altered_response_of1.16471327
69MP0002876_abnormal_thyroid_physiology1.16285178
70MP0000604_amyloidosis1.16056268
71MP0002067_abnormal_sensory_capabilities1.15771125
72MP0008789_abnormal_olfactory_epithelium1.15354794
73MP0005636_abnormal_mineral_homeostasis1.13619516
74MP0005423_abnormal_somatic_nervous1.12606089
75MP0005620_abnormal_muscle_contractility1.11853766
76MP0001188_hyperpigmentation1.11331778
77MP0005451_abnormal_body_composition1.10803495
78MP0002095_abnormal_skin_pigmentation1.07143600
79MP0000427_abnormal_hair_cycle1.06827309
80MP0001970_abnormal_pain_threshold1.05165698
81MP0000631_abnormal_neuroendocrine_gland1.04040281
82MP0002078_abnormal_glucose_homeostasis1.03109887
83MP0003186_abnormal_redox_activity1.02940817
84MP0001905_abnormal_dopamine_level0.99858853
85MP0002184_abnormal_innervation0.99354356
86MP0005248_abnormal_Harderian_gland0.96619415
87MP0005174_abnormal_tail_pigmentation0.95204075
88MP0000372_irregular_coat_pigmentation0.94220892
89MP0003136_yellow_coat_color0.93391549
90MP0002106_abnormal_muscle_physiology0.92828909
91MP0002557_abnormal_social/conspecific_i0.92704776
92MP0004811_abnormal_neuron_physiology0.91716241
93MP0002733_abnormal_thermal_nociception0.91636384
94MP0004270_analgesia0.91427496
95MP0002971_abnormal_brown_adipose0.90339792
96MP0005084_abnormal_gallbladder_morpholo0.88956382
97MP0006035_abnormal_mitochondrial_morpho0.88703339
98MP0002751_abnormal_autonomic_nervous0.88093412
99MP0004085_abnormal_heartbeat0.87789050
100MP0000955_abnormal_spinal_cord0.86666100
101MP0000013_abnormal_adipose_tissue0.86330659
102MP0001661_extended_life_span0.86179835
103MP0008775_abnormal_heart_ventricle0.86042561
104MP0002882_abnormal_neuron_morphology0.84738500
105MP0005394_taste/olfaction_phenotype0.84221469
106MP0005499_abnormal_olfactory_system0.84221469
107MP0009780_abnormal_chondrocyte_physiolo0.83556122
108MP0003221_abnormal_cardiomyocyte_apopto0.83395248
109MP0002127_abnormal_cardiovascular_syste0.83012648
110MP0003137_abnormal_impulse_conducting0.82461332
111MP0000647_abnormal_sebaceous_gland0.82032932
112MP0000920_abnormal_myelination0.81246482
113MP0002752_abnormal_somatic_nervous0.81194245
114MP0002332_abnormal_exercise_endurance0.80906310
115MP0005171_absent_coat_pigmentation0.80618329
116MP0005647_abnormal_sex_gland0.80532101
117MP0009764_decreased_sensitivity_to0.80358883
118MP0001501_abnormal_sleep_pattern0.79942241
119MP0004142_abnormal_muscle_tone0.79743958
120MP0002269_muscular_atrophy0.79041110
121MP0000747_muscle_weakness0.77746130
122MP0005334_abnormal_fat_pad0.76537539
123MP0002735_abnormal_chemical_nociception0.75751820
124MP0005376_homeostasis/metabolism_phenot0.74945343
125MP0004036_abnormal_muscle_relaxation0.74852053
126MP0000749_muscle_degeneration0.73469301
127MP0009642_abnormal_blood_homeostasis0.73261072
128MP0003880_abnormal_central_pattern0.72880590
129MP0000598_abnormal_liver_morphology0.72527817
130MP0000230_abnormal_systemic_arterial0.72433632
131MP0005266_abnormal_metabolism0.70336049
132MP0003183_abnormal_peptide_metabolism0.69100927
133MP0002272_abnormal_nervous_system0.68355252
134MP0003011_delayed_dark_adaptation0.68111235
135MP0004859_abnormal_synaptic_plasticity0.67696726
136MP0004145_abnormal_muscle_electrophysio0.66948072
137MP0002064_seizures0.66040593
138MP0005408_hypopigmentation0.65664910
139MP0001765_abnormal_ion_homeostasis0.64482278
140MP0005448_abnormal_energy_balance0.64156017
141MP0008874_decreased_physiological_sensi0.62694210
142MP0001756_abnormal_urination0.62593158
143MP0005666_abnormal_adipose_tissue0.62579040
144MP0009745_abnormal_behavioral_response0.62509098
145MP0002229_neurodegeneration0.60520926
146MP0006276_abnormal_autonomic_nervous0.60375438
147MP0009763_increased_sensitivity_to0.60145853
148MP0004215_abnormal_myocardial_fiber0.58764285
149MP0003633_abnormal_nervous_system0.58725465
150MP0001440_abnormal_grooming_behavior0.57983896
151MP0005058_abnormal_lysosome_morphology0.57079069
152MP0005220_abnormal_exocrine_pancreas0.56072149
153MP0009384_cardiac_valve_regurgitation0.56054070
154MP0003953_abnormal_hormone_level0.55172106
155MP0005330_cardiomyopathy0.54961210
156MP0000639_abnormal_adrenal_gland0.54309682
157MP0002736_abnormal_nociception_after0.53186909
158MP0003646_muscle_fatigue0.52263701
159MP0001486_abnormal_startle_reflex0.51262581
160MP0008872_abnormal_physiological_respon0.50637624
161MP0008260_abnormal_autophagy0.50458801
162MP0003631_nervous_system_phenotype0.50136585
163MP0002090_abnormal_vision0.49959736
164MP0001968_abnormal_touch/_nociception0.49601694
165MP0008469_abnormal_protein_level0.49583168
166MP0009046_muscle_twitch0.49360035
167MP0003075_altered_response_to0.49322638

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.23784951
2Intrahepatic cholestasis (HP:0001406)6.01058188
3Deep venous thrombosis (HP:0002625)5.69908139
4Prolonged partial thromboplastin time (HP:0003645)5.49305515
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.11873829
6Hypobetalipoproteinemia (HP:0003563)5.05024043
7Xanthomatosis (HP:0000991)5.04283258
8Hyperlipoproteinemia (HP:0010980)4.53681615
9Ketosis (HP:0001946)4.26727109
10Complement deficiency (HP:0004431)4.22541916
11Hyperglycinemia (HP:0002154)4.20411970
12Hyperammonemia (HP:0001987)4.03485973
13Hypoglycemic coma (HP:0001325)4.01977239
14Hypolipoproteinemia (HP:0010981)3.85780719
15Medial flaring of the eyebrow (HP:0010747)3.76928006
16Abnormality of glycine metabolism (HP:0010895)3.73126604
17Abnormality of serine family amino acid metabolism (HP:0010894)3.73126604
18Hyperglycinuria (HP:0003108)3.65864636
19Ketoacidosis (HP:0001993)3.64776992
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.63738246
21Abnormality of methionine metabolism (HP:0010901)3.58858999
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.56165221
23Exercise-induced muscle cramps (HP:0003710)3.55900697
24Joint hemorrhage (HP:0005261)3.55568961
25Abnormality of the common coagulation pathway (HP:0010990)3.52811285
26Fat malabsorption (HP:0002630)3.48109895
27Abnormality of fatty-acid metabolism (HP:0004359)3.42751779
28Hypoalphalipoproteinemia (HP:0003233)3.40391894
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.36431879
30Gait imbalance (HP:0002141)3.36153460
31Epidermoid cyst (HP:0200040)3.33016677
32Conjugated hyperbilirubinemia (HP:0002908)3.31215078
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27983489
34Congenital primary aphakia (HP:0007707)3.25893156
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.25323331
36Abnormality of the intrinsic pathway (HP:0010989)3.25142494
37Febrile seizures (HP:0002373)3.22743052
38Hyperbilirubinemia (HP:0002904)3.11209201
39Pancreatic cysts (HP:0001737)3.01718173
40Nephrogenic diabetes insipidus (HP:0009806)3.01172938
41Nephronophthisis (HP:0000090)3.00913891
42Gout (HP:0001997)2.98037819
43Abnormality of serum amino acid levels (HP:0003112)2.97357783
44Hyperinsulinemic hypoglycemia (HP:0000825)2.94560875
45Gaze-evoked nystagmus (HP:0000640)2.93583250
46Pancreatic fibrosis (HP:0100732)2.93431376
47True hermaphroditism (HP:0010459)2.92953621
48Genetic anticipation (HP:0003743)2.92231683
49Absent speech (HP:0001344)2.88547998
50Metabolic acidosis (HP:0001942)2.87979083
51Abnormality of complement system (HP:0005339)2.86397737
52Abnormal gallbladder morphology (HP:0012437)2.86074193
53Cerebral edema (HP:0002181)2.85156943
54Molar tooth sign on MRI (HP:0002419)2.81975023
55Abnormality of midbrain morphology (HP:0002418)2.81975023
56Hypoglycemic seizures (HP:0002173)2.81658191
57Cholelithiasis (HP:0001081)2.79413172
58Lethargy (HP:0001254)2.72507429
59Steatorrhea (HP:0002570)2.70788688
60Dicarboxylic aciduria (HP:0003215)2.69596936
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69596936
62Hypercholesterolemia (HP:0003124)2.66944789
63Genital tract atresia (HP:0001827)2.65426141
64Drooling (HP:0002307)2.60683754
65Abnormality of the renal cortex (HP:0011035)2.59051783
66Abnormality of purine metabolism (HP:0004352)2.57775285
67Delayed CNS myelination (HP:0002188)2.56065058
68Abnormality of the renal medulla (HP:0100957)2.55627729
69Abnormality of nucleobase metabolism (HP:0010932)2.53627322
70Calf muscle hypertrophy (HP:0008981)2.50991809
71Vaginal atresia (HP:0000148)2.50304442
72Amyotrophic lateral sclerosis (HP:0007354)2.49634539
73Abnormal gallbladder physiology (HP:0012438)2.49534741
74Cholecystitis (HP:0001082)2.49534741
75Skin nodule (HP:0200036)2.48054150
76Generalized aminoaciduria (HP:0002909)2.47591618
77Muscle fiber inclusion bodies (HP:0100299)2.47220298
78Progressive cerebellar ataxia (HP:0002073)2.46794163
79Chronic hepatic failure (HP:0100626)2.45974202
80Renal cortical cysts (HP:0000803)2.45419441
81Abnormality of pyrimidine metabolism (HP:0004353)2.45331396
82Nemaline bodies (HP:0003798)2.43105219
83Muscle hypertrophy of the lower extremities (HP:0008968)2.41664905
84Hypochromic microcytic anemia (HP:0004840)2.40384355
85Hypoplasia of the fovea (HP:0007750)2.39679100
86Aplasia/Hypoplasia of the fovea (HP:0008060)2.39679100
87Broad-based gait (HP:0002136)2.37928704
88Rimmed vacuoles (HP:0003805)2.36651002
89Pheochromocytoma (HP:0002666)2.35412716
90Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.33218003
91Vascular calcification (HP:0004934)2.31611678
92Thyroiditis (HP:0100646)2.30342750
93Progressive inability to walk (HP:0002505)2.30282803
94Excessive salivation (HP:0003781)2.28543430
95Hepatocellular carcinoma (HP:0001402)2.27616493
96Polyphagia (HP:0002591)2.26570585
97Hemiparesis (HP:0001269)2.25786343
98Irritability (HP:0000737)2.24748566
99Focal motor seizures (HP:0011153)2.23391693
100Myoglobinuria (HP:0002913)2.23258705
101Vomiting (HP:0002013)2.22881817
102Acanthocytosis (HP:0001927)2.22473726
103Volvulus (HP:0002580)2.21945814
104Poor coordination (HP:0002370)2.20771687
105Abnormality of the fovea (HP:0000493)2.20089803
106Sensorimotor neuropathy (HP:0007141)2.19385870
107Tubulointerstitial nephritis (HP:0001970)2.19226959
108Exercise-induced myalgia (HP:0003738)2.18646108
109Abnormality of the gallbladder (HP:0005264)2.18308714
110Abnormality of glycolysis (HP:0004366)2.17516864
111Increased serum pyruvate (HP:0003542)2.17516864
112Late onset (HP:0003584)2.17378315
113Spontaneous abortion (HP:0005268)2.15326780
114Acute encephalopathy (HP:0006846)2.14991439
115Brushfield spots (HP:0001088)2.13985990
116Symptomatic seizures (HP:0011145)2.12782943
117Aplasia/Hypoplasia of the tibia (HP:0005772)2.12279801
118Hypothermia (HP:0002045)2.11595451
119Inability to walk (HP:0002540)2.09333983
120Hyperventilation (HP:0002883)2.07319778
121Intestinal atresia (HP:0011100)2.07172841
122Neonatal onset (HP:0003623)2.05987900
123Cardiovascular calcification (HP:0011915)2.04678083
124Abnormality of the calf musculature (HP:0001430)2.04619015
125Congenital hepatic fibrosis (HP:0002612)2.04200637
126Anterior segment dysgenesis (HP:0007700)2.03016531
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02308688
128Abnormality of alanine metabolism (HP:0010916)2.02308688
129Hyperalaninemia (HP:0003348)2.02308688
130Neuroendocrine neoplasm (HP:0100634)2.01706188
131Abnormality of vitamin metabolism (HP:0100508)2.01576290
132Postaxial foot polydactyly (HP:0001830)1.99732639
133Status epilepticus (HP:0002133)1.99516602
134Papillary thyroid carcinoma (HP:0002895)1.99212308
135Hypoproteinemia (HP:0003075)1.97324508
136Mitral stenosis (HP:0001718)1.96466856
137Spastic paraparesis (HP:0002313)1.95083886
138Left ventricular hypertrophy (HP:0001712)1.94136411
139Fair hair (HP:0002286)1.93078903
140Hyperglycemia (HP:0003074)1.92930558
141Proximal tubulopathy (HP:0000114)1.92868014
142Poikilocytosis (HP:0004447)1.92734065
143Increased purine levels (HP:0004368)1.91824421
144Hyperuricemia (HP:0002149)1.91824421
145Rickets (HP:0002748)1.91687082
146Opisthotonus (HP:0002179)1.90899026
147Postaxial hand polydactyly (HP:0001162)1.89005516
148Methylmalonic acidemia (HP:0002912)1.88948497
149Glomerulonephritis (HP:0000099)1.88703811
150Hepatic necrosis (HP:0002605)1.88545202
151Widely spaced teeth (HP:0000687)1.87853703
152Abnormality of urine glucose concentration (HP:0011016)1.87672808
153Glycosuria (HP:0003076)1.87672808
154Short foot (HP:0001773)1.86965539
155Systemic lupus erythematosus (HP:0002725)1.86385866
156Alkalosis (HP:0001948)1.85966657
157Hypophosphatemic rickets (HP:0004912)1.85707971
158Myocardial infarction (HP:0001658)1.85579980
159Malnutrition (HP:0004395)1.83881983
160Cerebral hemorrhage (HP:0001342)1.80776010
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.80179564
162Abnormality of the left ventricular outflow tract (HP:0011103)1.79889385
163Subaortic stenosis (HP:0001682)1.79889385
1643-Methylglutaconic aciduria (HP:0003535)1.79721520
165Attenuation of retinal blood vessels (HP:0007843)1.79656833
166Acute hepatic failure (HP:0006554)1.79536256
167Reticulocytosis (HP:0001923)1.79376406
168EEG with generalized epileptiform discharges (HP:0011198)1.79175102
169Pancreatitis (HP:0001733)1.77818641
170Specific learning disability (HP:0001328)1.77496839
171Congenital stationary night blindness (HP:0007642)1.75784626
172Abnormal drinking behavior (HP:0030082)1.75246895
173Polydipsia (HP:0001959)1.75246895
174Focal seizures (HP:0007359)1.74069634
175Epileptiform EEG discharges (HP:0011182)1.74050140
176Cerebellar dysplasia (HP:0007033)1.73623529
177Hypsarrhythmia (HP:0002521)1.72722617
178Long clavicles (HP:0000890)1.72389670
179Aplasia/Hypoplasia of the lens (HP:0008063)1.72139031
180Broad foot (HP:0001769)1.71276182
181Hip dysplasia (HP:0001385)1.70686293
182Large for gestational age (HP:0001520)1.67933622
183Agitation (HP:0000713)1.67497467
184Decreased testicular size (HP:0008734)1.65528248
185Abnormality of the musculature of the pelvis (HP:0001469)1.65132140
186Abnormality of the hip-girdle musculature (HP:0001445)1.65132140
187Thyroid carcinoma (HP:0002890)1.64948253
188Atonic seizures (HP:0010819)1.64863603
189Albinism (HP:0001022)1.64733949
190Dyskinesia (HP:0100660)1.64489404
191Cystic liver disease (HP:0006706)1.63666182
192Type II lissencephaly (HP:0007260)1.62472530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.98834312
2INSRR3.43046447
3MAP2K43.07998100
4MARK12.63931396
5TAOK32.55286568
6STK392.54613681
7PIK3CG2.54577762
8OXSR12.53692862
9SIK12.51718668
10TRIM282.37951815
11PINK12.28092550
12ERBB32.25043794
13BMPR1B2.21623839
14ERBB42.18059954
15WNK42.07319371
16EPHA41.92798773
17MAPK131.87218226
18MAP4K21.75508933
19OBSCN1.72101443
20PHKG21.63750825
21PHKG11.63750825
22DAPK21.62965399
23FGFR41.62585805
24NTRK31.61700897
25PLK21.59957288
26MAP3K41.50211178
27ERN11.49537167
28CASK1.44737005
29ACVR1B1.43043527
30NUAK11.41008343
31SGK2231.34910324
32SGK4941.34910324
33MET1.28620381
34PDK41.27851322
35PDK31.27851322
36NTRK11.25437295
37MAP3K71.23223016
38MAP3K121.22979605
39MAP3K131.21479343
40CAMK2G1.18966849
41MAP2K71.18820017
42AKT31.17093160
43KSR11.14012005
44EPHB11.12565094
45KSR21.12470291
46NEK91.10948604
47ADRBK21.08392293
48CSNK1A1L1.05939147
49ARAF1.04504044
50MAPK111.04238311
51FRK1.03604851
52PRKAA21.03558995
53TXK1.03453751
54MAP3K21.01847602
55PAK31.01374514
56MST1R0.99708762
57BCR0.98793553
58EIF2AK30.95078895
59WNK30.94419000
60SGK20.94045737
61PRKCG0.92266389
62GRK50.91987161
63PIK3CA0.89897454
64CAMK2A0.89877587
65MAPK120.89712308
66WNK10.88892562
67PAK60.88473477
68MKNK20.87443188
69FGFR20.87114506
70PDK20.87039260
71PDPK10.85463016
72PRPF4B0.85237790
73NTRK20.84985667
74CSNK1G20.82924713
75LATS10.81612913
76DYRK30.81270107
77GRK70.80704847
78MKNK10.78945453
79PBK0.78860527
80CAMK2B0.76744891
81RPS6KA40.75956559
82CAMKK20.75729708
83CAMK2D0.75709715
84PRKCQ0.73270508
85SGK30.72489487
86ABL20.72464112
87PRKAA10.72237071
88PKN10.71305728
89LIMK10.71216683
90PRKACG0.70618808
91MAPK150.70372400
92TNIK0.70005518
93CCNB10.69563994
94MAP3K10.69151446
95PRKG10.68817082
96PLK40.67586931
97JAK20.65935181
98PTK2B0.64732600
99EIF2AK10.63921393
100STK30.63302817
101MAP2K10.63207597
102SIK30.62596069
103RET0.61312120
104MAP3K60.61226508
105NEK60.61012705
106BRSK20.60557729
107MINK10.58663937
108DYRK1A0.56843735
109FER0.55748977
110PRKACA0.55227186
111UHMK10.54891901
112DYRK20.53529950
113ADRBK10.52169334
114SRPK10.51640590
115PTK20.51158508
116CAMKK10.50798081
117PRKCE0.50774641
118CAMK1G0.49851321
119PDK10.49054053
120MUSK0.47794389
121CDK50.47618202
122PRKCZ0.47331854
123STK380.46800011
124TTN0.46580063
125CSNK1G30.44426024
126MAP2K30.44009345
127CAMK40.43792752
128PRKCA0.43481559
129MAPK70.43272524
130LMTK20.42595026
131GRK10.42513575
132PRKD30.42393016
133STK38L0.42089735
134CSNK1D0.42007845
135NEK10.41551607
136MAPKAPK30.41366642
137RPS6KA30.40931195
138EPHA30.40840584
139CAMK10.40521497
140PRKACB0.40403920
141CSNK1G10.40351172
142CSNK1A10.38342522
143MAP3K50.38118744
144RAF10.36331008
145PLK30.33428551
146RPS6KB10.32186596

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.97072807
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25296457
3Nitrogen metabolism_Homo sapiens_hsa009103.16595045
4Arginine biosynthesis_Homo sapiens_hsa002202.80788489
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.75608437
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66192706
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61492764
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60378380
9Tryptophan metabolism_Homo sapiens_hsa003802.56918671
10Fatty acid degradation_Homo sapiens_hsa000712.48437252
11Butanoate metabolism_Homo sapiens_hsa006502.42735621
12Propanoate metabolism_Homo sapiens_hsa006402.37463432
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27150891
14Complement and coagulation cascades_Homo sapiens_hsa046102.24478115
15Peroxisome_Homo sapiens_hsa041462.10672192
16Non-homologous end-joining_Homo sapiens_hsa034501.94277281
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91736332
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91549472
19Fatty acid metabolism_Homo sapiens_hsa012121.91483998
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.91185069
21Histidine metabolism_Homo sapiens_hsa003401.86734231
22Fatty acid elongation_Homo sapiens_hsa000621.80226928
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77257638
24Sulfur metabolism_Homo sapiens_hsa009201.76063610
25Pyruvate metabolism_Homo sapiens_hsa006201.76010404
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75841157
27beta-Alanine metabolism_Homo sapiens_hsa004101.73198380
28Taste transduction_Homo sapiens_hsa047421.67389710
29PPAR signaling pathway_Homo sapiens_hsa033201.65739834
30Circadian entrainment_Homo sapiens_hsa047131.65688709
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63035658
32Chemical carcinogenesis_Homo sapiens_hsa052041.61071649
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.60882770
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57540345
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56590403
36Phenylalanine metabolism_Homo sapiens_hsa003601.50573912
37Bile secretion_Homo sapiens_hsa049761.43655489
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41175416
39Tyrosine metabolism_Homo sapiens_hsa003501.39989573
40Morphine addiction_Homo sapiens_hsa050321.39157804
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38878650
42Retinol metabolism_Homo sapiens_hsa008301.38710747
43Glutamatergic synapse_Homo sapiens_hsa047241.38271582
44Phototransduction_Homo sapiens_hsa047441.36307879
45Caffeine metabolism_Homo sapiens_hsa002321.34984097
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33474104
47Serotonergic synapse_Homo sapiens_hsa047261.33237260
48Dopaminergic synapse_Homo sapiens_hsa047281.32270576
49Long-term depression_Homo sapiens_hsa047301.26091856
50Amphetamine addiction_Homo sapiens_hsa050311.25886169
51Starch and sucrose metabolism_Homo sapiens_hsa005001.25796714
52Staphylococcus aureus infection_Homo sapiens_hsa051501.24517595
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.23956440
54Carbon metabolism_Homo sapiens_hsa012001.23736782
55ABC transporters_Homo sapiens_hsa020101.22857021
56Renin secretion_Homo sapiens_hsa049241.22681116
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21525889
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.21001439
59Steroid biosynthesis_Homo sapiens_hsa001001.20311804
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.18107377
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15867952
62Arginine and proline metabolism_Homo sapiens_hsa003301.14327374
63Selenocompound metabolism_Homo sapiens_hsa004501.11215260
64Biosynthesis of amino acids_Homo sapiens_hsa012301.04228845
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03550307
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01616789
67Basal transcription factors_Homo sapiens_hsa030221.01164009
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00803249
69Salivary secretion_Homo sapiens_hsa049701.00508247
70Cocaine addiction_Homo sapiens_hsa050301.00419787
71Dorso-ventral axis formation_Homo sapiens_hsa043201.00401265
72Olfactory transduction_Homo sapiens_hsa047401.00351840
73Folate biosynthesis_Homo sapiens_hsa007900.97196653
74Fat digestion and absorption_Homo sapiens_hsa049750.89193812
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.87251583
76Vitamin B6 metabolism_Homo sapiens_hsa007500.87187040
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84158094
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83864839
79Gastric acid secretion_Homo sapiens_hsa049710.81379015
80Calcium signaling pathway_Homo sapiens_hsa040200.80246309
81Oocyte meiosis_Homo sapiens_hsa041140.77806072
82Long-term potentiation_Homo sapiens_hsa047200.76876914
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73525418
84Oxytocin signaling pathway_Homo sapiens_hsa049210.73455606
85Dilated cardiomyopathy_Homo sapiens_hsa054140.70225475
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69811533
87Glycerolipid metabolism_Homo sapiens_hsa005610.69111986
88Sulfur relay system_Homo sapiens_hsa041220.68274664
89cAMP signaling pathway_Homo sapiens_hsa040240.67967224
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.67869759
91Vitamin digestion and absorption_Homo sapiens_hsa049770.67609325
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67169529
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66909739
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59880462
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59683087
96Cholinergic synapse_Homo sapiens_hsa047250.58567510
97Lysine degradation_Homo sapiens_hsa003100.57536359
98Glutathione metabolism_Homo sapiens_hsa004800.57028410
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56320447
100Pancreatic secretion_Homo sapiens_hsa049720.55943889
101Metabolic pathways_Homo sapiens_hsa011000.55730632
102Hedgehog signaling pathway_Homo sapiens_hsa043400.52359706
103Oxidative phosphorylation_Homo sapiens_hsa001900.51512860
104Fanconi anemia pathway_Homo sapiens_hsa034600.50007739
105Gap junction_Homo sapiens_hsa045400.49053104
106Fatty acid biosynthesis_Homo sapiens_hsa000610.48589859
107Platelet activation_Homo sapiens_hsa046110.47457005
108RNA degradation_Homo sapiens_hsa030180.46850886
109Regulation of autophagy_Homo sapiens_hsa041400.34784360
110Prion diseases_Homo sapiens_hsa050200.34506387
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33040632
112Pentose phosphate pathway_Homo sapiens_hsa000300.32493912
113Glucagon signaling pathway_Homo sapiens_hsa049220.29967866
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29608452
115Parkinsons disease_Homo sapiens_hsa050120.27370810
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.26988836
117Linoleic acid metabolism_Homo sapiens_hsa005910.26891201
118Alzheimers disease_Homo sapiens_hsa050100.25163017
119Fructose and mannose metabolism_Homo sapiens_hsa000510.24514528
120GABAergic synapse_Homo sapiens_hsa047270.23970406
121Insulin resistance_Homo sapiens_hsa049310.23226920
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.22104585
123Collecting duct acid secretion_Homo sapiens_hsa049660.17910231
124Insulin secretion_Homo sapiens_hsa049110.12370438
125Protein export_Homo sapiens_hsa030600.10637075
126Ovarian steroidogenesis_Homo sapiens_hsa049130.09040045
127Galactose metabolism_Homo sapiens_hsa000520.07900697
128Circadian rhythm_Homo sapiens_hsa047100.07525586
129Cardiac muscle contraction_Homo sapiens_hsa042600.06545748
130AMPK signaling pathway_Homo sapiens_hsa041520.06389245
131Synaptic vesicle cycle_Homo sapiens_hsa047210.04680346
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02715836
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.02677840
134Thyroid hormone synthesis_Homo sapiens_hsa049180.02175663
135Insulin signaling pathway_Homo sapiens_hsa049100.01836204
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.01135682
137Ether lipid metabolism_Homo sapiens_hsa005650.00850549
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0372958
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0295632
140Nicotine addiction_Homo sapiens_hsa05033-0.0245710
141Type II diabetes mellitus_Homo sapiens_hsa04930-0.0042628

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