SCRT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.53332431
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.28624985
3locomotory exploration behavior (GO:0035641)6.24473052
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.84949380
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.78282694
6vocalization behavior (GO:0071625)5.60256690
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.41407022
8synaptic vesicle exocytosis (GO:0016079)5.28241147
9regulation of synaptic vesicle exocytosis (GO:2000300)5.17644852
10glutamate secretion (GO:0014047)5.14887312
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.96475918
12regulation of glutamate receptor signaling pathway (GO:1900449)4.95747639
13layer formation in cerebral cortex (GO:0021819)4.95088647
14neuronal action potential propagation (GO:0019227)4.86588805
15neurotransmitter secretion (GO:0007269)4.71301695
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.66429857
17protein localization to synapse (GO:0035418)4.64588696
18regulation of synaptic vesicle transport (GO:1902803)4.60662529
19dendritic spine morphogenesis (GO:0060997)4.60160148
20exploration behavior (GO:0035640)4.59718060
21regulation of neuronal synaptic plasticity (GO:0048168)4.56359547
22gamma-aminobutyric acid transport (GO:0015812)4.54990821
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53100126
24central nervous system myelination (GO:0022010)4.50817157
25axon ensheathment in central nervous system (GO:0032291)4.50817157
26regulation of synapse structural plasticity (GO:0051823)4.45926811
27neurofilament cytoskeleton organization (GO:0060052)4.22609475
28neuron cell-cell adhesion (GO:0007158)4.22589855
29substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.19397216
30substrate-independent telencephalic tangential migration (GO:0021826)4.19397216
31cellular potassium ion homeostasis (GO:0030007)4.19083437
32synaptic transmission, glutamatergic (GO:0035249)4.14153345
33presynaptic membrane organization (GO:0097090)4.13831404
34glycine transport (GO:0015816)4.11298281
35sodium ion export (GO:0071436)4.11282091
36glutamate receptor signaling pathway (GO:0007215)4.05110174
37cerebellar Purkinje cell differentiation (GO:0021702)4.04714930
38establishment of mitochondrion localization (GO:0051654)4.00978530
39long-term memory (GO:0007616)3.96854282
40behavioral response to nicotine (GO:0035095)3.96759664
41neurotransmitter-gated ion channel clustering (GO:0072578)3.95505159
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92059617
43positive regulation of membrane potential (GO:0045838)3.90276597
44pyrimidine nucleobase catabolic process (GO:0006208)3.87556087
45neuron-neuron synaptic transmission (GO:0007270)3.85913063
46neuromuscular process controlling balance (GO:0050885)3.85183754
47proline transport (GO:0015824)3.84129239
48neurotransmitter transport (GO:0006836)3.79565534
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.72908560
50auditory behavior (GO:0031223)3.71196867
51spinal cord association neuron differentiation (GO:0021527)3.69826854
52establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.68989202
53mitochondrion transport along microtubule (GO:0047497)3.68989202
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66105859
55positive regulation of synapse maturation (GO:0090129)3.62069741
56transmission of nerve impulse (GO:0019226)3.60767590
57regulation of dendritic spine morphogenesis (GO:0061001)3.60333063
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.59620386
59neuromuscular process controlling posture (GO:0050884)3.56070048
60activation of protein kinase A activity (GO:0034199)3.56035329
61regulation of postsynaptic membrane potential (GO:0060078)3.54843154
62dendrite morphogenesis (GO:0048813)3.53083703
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51723891
64neuron recognition (GO:0008038)3.51628421
65regulation of neurotransmitter levels (GO:0001505)3.49945009
66regulation of synaptic plasticity (GO:0048167)3.48721880
67regulation of neurotransmitter secretion (GO:0046928)3.45571025
68response to auditory stimulus (GO:0010996)3.44752121
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.44197631
70cell communication by electrical coupling (GO:0010644)3.42665991
71prepulse inhibition (GO:0060134)3.42008527
72L-amino acid import (GO:0043092)3.38774539
73synaptic vesicle endocytosis (GO:0048488)3.36670611
74neuronal ion channel clustering (GO:0045161)3.36548834
75neuromuscular synaptic transmission (GO:0007274)3.33629049
76axonal fasciculation (GO:0007413)3.32814864
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.28431755
78cerebellar granule cell differentiation (GO:0021707)3.25986771
79cell migration in hindbrain (GO:0021535)3.24379151
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24351300
81membrane depolarization during action potential (GO:0086010)3.23032379
82regulation of ARF protein signal transduction (GO:0032012)3.22543443
83dendritic spine organization (GO:0097061)3.22004793
84regulation of neurotransmitter transport (GO:0051588)3.20764973
85regulation of synaptic transmission, glutamatergic (GO:0051966)3.20586276
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19886767
87membrane hyperpolarization (GO:0060081)3.19443971
88positive regulation of dendritic spine development (GO:0060999)3.17600771
89postsynaptic membrane organization (GO:0001941)3.17465707
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16357390
91nucleobase catabolic process (GO:0046113)3.16216969
92membrane depolarization (GO:0051899)3.15998461
93response to pheromone (GO:0019236)3.15927380
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14602677
95potassium ion import (GO:0010107)3.14004609
96regulation of vesicle fusion (GO:0031338)3.12011016
97forebrain neuron differentiation (GO:0021879)3.10947015
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10776464
99positive regulation of neurotransmitter transport (GO:0051590)3.09557136
100long-term synaptic potentiation (GO:0060291)3.08413248
101neuromuscular process (GO:0050905)3.08327105
102gamma-aminobutyric acid signaling pathway (GO:0007214)3.08263119
103positive regulation of gastrulation (GO:2000543)3.08199149
104mechanosensory behavior (GO:0007638)3.07890046
105calcium ion-dependent exocytosis (GO:0017156)3.07799063
106cerebellar Purkinje cell layer development (GO:0021680)3.07240951
107cerebellum development (GO:0021549)3.07164872
108positive regulation of neurotransmitter secretion (GO:0001956)3.05683411
109urogenital system development (GO:0001655)3.05617310
110negative regulation of neurotransmitter secretion (GO:0046929)3.05120846
111adult walking behavior (GO:0007628)3.04229768
112regulation of dendritic spine development (GO:0060998)3.03375891
113negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02670978
114G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01516493
115cell differentiation in hindbrain (GO:0021533)3.01322904
116mating behavior (GO:0007617)3.00821024
117potassium ion homeostasis (GO:0055075)2.99160153
118social behavior (GO:0035176)2.98362993
119intraspecies interaction between organisms (GO:0051703)2.98362993
120learning (GO:0007612)2.98057480
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.97988395
122synapse assembly (GO:0007416)2.95601896
123adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.95263767
124regulation of synapse maturation (GO:0090128)2.93617384
125regulation of microtubule-based movement (GO:0060632)2.76806601
126axon extension (GO:0048675)2.76654297
127membrane repolarization (GO:0086009)2.74445453
128negative regulation of axonogenesis (GO:0050771)2.74380535
129positive regulation of dendritic spine morphogenesis (GO:0061003)2.73914528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96037466
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11155208
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09777719
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08404470
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94757361
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87470362
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87470362
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.82226598
9DROSHA_22980978_ChIP-Seq_HELA_Human2.78045050
10GBX2_23144817_ChIP-Seq_PC3_Human2.77582412
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.73843037
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72100687
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59992662
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59902606
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54614975
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.54052708
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52771693
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52044906
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.45707367
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43907868
21* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.42237052
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.33215963
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.31746625
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29875555
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.28295466
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.28248986
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12328822
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03158415
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80322399
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.78519710
31AR_21572438_ChIP-Seq_LNCaP_Human1.75105510
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70647982
33* RING1B_27294783_Chip-Seq_ESCs_Mouse1.47996466
34* KDM2B_26808549_Chip-Seq_K562_Human1.46569194
35* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46132547
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42692837
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41597957
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37865897
39SMAD4_21799915_ChIP-Seq_A2780_Human1.35029391
40* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34867605
41ZNF274_21170338_ChIP-Seq_K562_Hela1.33114699
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32143914
43* RING1B_27294783_Chip-Seq_NPCs_Mouse1.27273589
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.26706889
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25801098
46* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25685925
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24426720
48AR_19668381_ChIP-Seq_PC3_Human1.23246415
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22195797
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21014518
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.20128398
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19044919
53* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18016117
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17977816
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16482012
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14592772
57OCT4_19829295_ChIP-Seq_ESCs_Human1.14309042
58* CBX2_27304074_Chip-Seq_ESCs_Mouse1.11239270
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10518965
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10518965
61* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09420647
62* LXR_22292898_ChIP-Seq_THP-1_Human1.08496946
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08480466
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07116338
65TAF15_26573619_Chip-Seq_HEK293_Human1.05804284
66STAT3_23295773_ChIP-Seq_U87_Human1.05804105
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05460674
68* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05418637
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.03599929
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03279044
71* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01810335
72AR_25329375_ChIP-Seq_VCAP_Human1.01192888
73ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97869201
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97796540
75TET1_21490601_ChIP-Seq_MESCs_Mouse0.97395460
76RNF2_27304074_Chip-Seq_NSC_Mouse0.96894540
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96652263
78YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96562992
79CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96070670
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95386660
81SMAD_19615063_ChIP-ChIP_OVARY_Human0.95110158
82CTCF_27219007_Chip-Seq_Bcells_Human0.94810954
83BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94810618
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94376239
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93959054
86P300_19829295_ChIP-Seq_ESCs_Human0.93353987
87SMAD4_21741376_ChIP-Seq_HESCs_Human0.93285597
88SMAD3_21741376_ChIP-Seq_ESCs_Human0.92243164
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92189189
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91726378
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91550396
92TCF4_23295773_ChIP-Seq_U87_Human0.91491187
93SMC4_20622854_ChIP-Seq_HELA_Human0.91111016
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.90734041
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90539055
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89850047
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88722613
98* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88719475
99AHR_22903824_ChIP-Seq_MCF-7_Human0.88503239
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.88422377
101* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88369586
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87982517
103* P68_20966046_ChIP-Seq_HELA_Human0.87499391
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86324129
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86097349
106ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85448452
107* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83867776
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.83661102
109RXR_22108803_ChIP-Seq_LS180_Human0.83646562
110* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.82274533
111* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81292678
112NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81092289
113KLF4_19829295_ChIP-Seq_ESCs_Human0.79901430
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79775004
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.78850613
116* SMAD4_21741376_ChIP-Seq_ESCs_Human0.78762256
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78528649
118* KDM2B_26808549_Chip-Seq_JURKAT_Human0.78512641
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77556315
120* RUNX2_22187159_ChIP-Seq_PCA_Human0.77267386
121* CREB1_26743006_Chip-Seq_LNCaP_Human0.76188508
122SA1_27219007_Chip-Seq_Bcells_Human0.76059341
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75917042
124* DPY_21335234_ChIP-Seq_ESCs_Mouse0.73940323
125ETV2_25802403_ChIP-Seq_MESCs_Mouse0.72719410
126TET1_21451524_ChIP-Seq_MESCs_Mouse0.71684872
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.69036640
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.68051971
129WDR5_24793694_ChIP-Seq_LNCAP_Human0.66849817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.84213573
2MP0003880_abnormal_central_pattern4.55454226
3MP0003635_abnormal_synaptic_transmissio4.27609830
4MP0004270_analgesia3.82134187
5MP0009745_abnormal_behavioral_response3.39541420
6MP0009046_muscle_twitch3.35311571
7MP0002063_abnormal_learning/memory/cond3.32919468
8MP0005423_abnormal_somatic_nervous3.31618336
9MP0002064_seizures3.19929093
10MP0003123_paternal_imprinting3.16472259
11MP0001968_abnormal_touch/_nociception2.81699013
12MP0001486_abnormal_startle_reflex2.71092712
13MP0002572_abnormal_emotion/affect_behav2.70854744
14MP0002734_abnormal_mechanical_nocicepti2.70161823
15MP0002272_abnormal_nervous_system2.65460681
16MP0002822_catalepsy2.60123720
17MP0008569_lethality_at_weaning2.27391651
18MP0001501_abnormal_sleep_pattern2.23548093
19MP0002733_abnormal_thermal_nociception2.08792654
20MP0001440_abnormal_grooming_behavior2.05612462
21MP0002909_abnormal_adrenal_gland2.01053686
22MP0002067_abnormal_sensory_capabilities1.99151346
23MP0002736_abnormal_nociception_after1.98790901
24MP0001970_abnormal_pain_threshold1.98581790
25MP0006292_abnormal_olfactory_placode1.96679208
26MP0009780_abnormal_chondrocyte_physiolo1.93885313
27MP0002735_abnormal_chemical_nociception1.93543995
28MP0004811_abnormal_neuron_physiology1.91517829
29MP0003329_amyloid_beta_deposits1.89899590
30MP0000778_abnormal_nervous_system1.89191283
31MP0002184_abnormal_innervation1.88302843
32MP0004858_abnormal_nervous_system1.88069910
33MP0002557_abnormal_social/conspecific_i1.80033464
34MP0004885_abnormal_endolymph1.78932537
35MP0000955_abnormal_spinal_cord1.75500187
36MP0004924_abnormal_behavior1.69748502
37MP0005386_behavior/neurological_phenoty1.69748502
38MP0003121_genomic_imprinting1.58525054
39MP0005646_abnormal_pituitary_gland1.57442931
40MP0003879_abnormal_hair_cell1.50740592
41MP0002882_abnormal_neuron_morphology1.50276815
42MP0002066_abnormal_motor_capabilities/c1.49672691
43MP0006276_abnormal_autonomic_nervous1.46604029
44MP0001348_abnormal_lacrimal_gland1.45220412
45MP0003633_abnormal_nervous_system1.43633776
46MP0002653_abnormal_ependyma_morphology1.41225593
47MP0003787_abnormal_imprinting1.37031057
48MP0004142_abnormal_muscle_tone1.35629407
49MP0001984_abnormal_olfaction1.35617111
50MP0000569_abnormal_digit_pigmentation1.34928304
51MP0001502_abnormal_circadian_rhythm1.25814825
52MP0003283_abnormal_digestive_organ1.24650448
53MP0005645_abnormal_hypothalamus_physiol1.23933716
54MP0003631_nervous_system_phenotype1.21497325
55MP0002152_abnormal_brain_morphology1.20272186
56MP0003890_abnormal_embryonic-extraembry1.15279415
57MP0004145_abnormal_muscle_electrophysio1.14279346
58MP0008961_abnormal_basal_metabolism1.11466877
59MP0008877_abnormal_DNA_methylation1.10072261
60MP0003690_abnormal_glial_cell1.09301392
61MP0004742_abnormal_vestibular_system1.06097924
62MP0000920_abnormal_myelination1.03531217
63MP0001986_abnormal_taste_sensitivity1.01399424
64MP0002229_neurodegeneration1.00767882
65MP0008872_abnormal_physiological_respon0.99086678
66MP0003122_maternal_imprinting0.98737186
67MP0003632_abnormal_nervous_system0.95335853
68MP0001529_abnormal_vocalization0.95326928
69MP0001905_abnormal_dopamine_level0.95057367
70MP0002069_abnormal_eating/drinking_beha0.94999558
71MP0003075_altered_response_to0.93631564
72MP0003634_abnormal_glial_cell0.92574095
73MP0001177_atelectasis0.90757786
74MP0009379_abnormal_foot_pigmentation0.88321410
75MP0008874_decreased_physiological_sensi0.86451051
76MP0005551_abnormal_eye_electrophysiolog0.85901079
77MP0002876_abnormal_thyroid_physiology0.84319041
78MP0004130_abnormal_muscle_cell0.83590553
79MP0005394_taste/olfaction_phenotype0.82786777
80MP0005499_abnormal_olfactory_system0.82786777
81MP0000751_myopathy0.82662766
82MP0000013_abnormal_adipose_tissue0.82223650
83MP0002163_abnormal_gland_morphology0.82022851
84MP0005410_abnormal_fertilization0.81901173
85MP0000604_amyloidosis0.81250960
86MP0000534_abnormal_ureter_morphology0.80922669
87MP0003938_abnormal_ear_development0.80879819
88MP0000026_abnormal_inner_ear0.80751663
89MP0004085_abnormal_heartbeat0.80566102
90MP0005167_abnormal_blood-brain_barrier0.79336355
91MP0003137_abnormal_impulse_conducting0.78786299
92MP0001963_abnormal_hearing_physiology0.78403106
93MP0000631_abnormal_neuroendocrine_gland0.78097629
94MP0003172_abnormal_lysosome_physiology0.77493472
95MP0005535_abnormal_body_temperature0.77393605
96MP0002752_abnormal_somatic_nervous0.77084723
97MP0008789_abnormal_olfactory_epithelium0.75192315
98MP0001485_abnormal_pinna_reflex0.71509491
99MP0001299_abnormal_eye_distance/0.71221453
100MP0005623_abnormal_meninges_morphology0.71138094
101MP0003942_abnormal_urinary_system0.68853471
102MP0001188_hyperpigmentation0.68166677
103MP0003861_abnormal_nervous_system0.67203821
104MP0002160_abnormal_reproductive_system0.67151496
105MP0002638_abnormal_pupillary_reflex0.66208813
106MP0004134_abnormal_chest_morphology0.65590256
107MP0002090_abnormal_vision0.65528395
108MP0003011_delayed_dark_adaptation0.64776686
109MP0010386_abnormal_urinary_bladder0.64089806
110MP0005187_abnormal_penis_morphology0.63277972
111MP0004133_heterotaxia0.62579779
112MP0004043_abnormal_pH_regulation0.60646681
113MP0003698_abnormal_male_reproductive0.59703287
114MP0010769_abnormal_survival0.59511827
115MP0003948_abnormal_gas_homeostasis0.59439831
116MP0005379_endocrine/exocrine_gland_phen0.59208624
117MP0005195_abnormal_posterior_eye0.57821186
118MP0005409_darkened_coat_color0.57797040
119MP0001943_abnormal_respiration0.57524430
120MP0004510_myositis0.56570982
121MP0002082_postnatal_lethality0.55836036
122MP0010770_preweaning_lethality0.55836036
123MP0010768_mortality/aging0.55725310
124MP0004215_abnormal_myocardial_fiber0.55331836
125MP0002089_abnormal_postnatal_growth/wei0.52022084
126MP0004233_abnormal_muscle_weight0.51531935

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.08694146
2Focal motor seizures (HP:0011153)6.84190891
3Focal seizures (HP:0007359)5.56525822
4Visual hallucinations (HP:0002367)5.48688897
5Abnormal pancreas size (HP:0012094)4.70013158
6Action tremor (HP:0002345)4.64839164
7Progressive cerebellar ataxia (HP:0002073)4.62944837
8Supranuclear gaze palsy (HP:0000605)4.34326495
9Epileptic encephalopathy (HP:0200134)4.26115582
10Atonic seizures (HP:0010819)4.07855269
11Febrile seizures (HP:0002373)3.99874042
12Ankle clonus (HP:0011448)3.83209714
13Absence seizures (HP:0002121)3.72797471
14Generalized tonic-clonic seizures (HP:0002069)3.60965518
15Broad-based gait (HP:0002136)3.53826247
16Poor eye contact (HP:0000817)3.51207992
17Gaze-evoked nystagmus (HP:0000640)3.42855707
18Dysdiadochokinesis (HP:0002075)3.36166837
19Papilledema (HP:0001085)3.34345748
20Dialeptic seizures (HP:0011146)3.34324315
21Depression (HP:0000716)3.33841944
22Impaired vibration sensation in the lower limbs (HP:0002166)3.29586755
23Mutism (HP:0002300)3.22673923
24Abnormal social behavior (HP:0012433)3.19385160
25Impaired social interactions (HP:0000735)3.19385160
26Dysmetria (HP:0001310)3.18814093
27Genetic anticipation (HP:0003743)3.14833132
28Urinary bladder sphincter dysfunction (HP:0002839)3.14821903
29Postural instability (HP:0002172)3.10438862
30Hemiplegia (HP:0002301)3.01914203
31Anxiety (HP:0000739)3.00886003
32Abnormal eating behavior (HP:0100738)3.00582139
33Hemiparesis (HP:0001269)3.00189827
34Truncal ataxia (HP:0002078)3.00181876
35Intention tremor (HP:0002080)2.98476203
36Anomalous pulmonary venous return (HP:0010772)2.97680137
37Impaired smooth pursuit (HP:0007772)2.96904622
38Hepatoblastoma (HP:0002884)2.92238825
39Abnormality of the lower motor neuron (HP:0002366)2.90760825
40Urinary urgency (HP:0000012)2.88049766
41Ventricular fibrillation (HP:0001663)2.81766990
42Torticollis (HP:0000473)2.76360199
43Spastic gait (HP:0002064)2.76245897
44Insomnia (HP:0100785)2.71339281
45Diplopia (HP:0000651)2.71087715
46Abnormality of binocular vision (HP:0011514)2.71087715
47Scanning speech (HP:0002168)2.70361098
48Amblyopia (HP:0000646)2.66893165
49Megalencephaly (HP:0001355)2.65062567
50Hyperthyroidism (HP:0000836)2.63734696
51Neurofibrillary tangles (HP:0002185)2.60777300
52Annular pancreas (HP:0001734)2.60621141
53Abnormality of ocular smooth pursuit (HP:0000617)2.58845113
54Cerebral hypomyelination (HP:0006808)2.58423546
55Stereotypic behavior (HP:0000733)2.56724519
56Abnormality of the pulmonary veins (HP:0011718)2.54063979
57Focal dystonia (HP:0004373)2.52170049
58Pointed chin (HP:0000307)2.51169842
59Shawl scrotum (HP:0000049)2.50787933
60Neonatal hypoglycemia (HP:0001998)2.50690913
61Dysmetric saccades (HP:0000641)2.50541649
62Drooling (HP:0002307)2.49432530
63Excessive salivation (HP:0003781)2.49432530
64Neoplasm of the adrenal cortex (HP:0100641)2.46388329
65Hyperventilation (HP:0002883)2.41895619
66Spastic tetraplegia (HP:0002510)2.41653843
67Cerebral inclusion bodies (HP:0100314)2.40266672
68Progressive inability to walk (HP:0002505)2.37705757
69Diastasis recti (HP:0001540)2.37586059
70Thoracolumbar scoliosis (HP:0002944)2.37253944
71Bradykinesia (HP:0002067)2.37244773
72Agitation (HP:0000713)2.34713778
73Sleep apnea (HP:0010535)2.33062028
74Status epilepticus (HP:0002133)2.29155026
75Abnormality of the corticospinal tract (HP:0002492)2.29152140
76Metaphyseal dysplasia (HP:0100255)2.28169114
77Spastic tetraparesis (HP:0001285)2.27994657
78Abnormality of macular pigmentation (HP:0008002)2.25313657
79Bundle branch block (HP:0011710)2.23684121
80Insidious onset (HP:0003587)2.22520363
81Termporal pattern (HP:0011008)2.22520363
82Craniofacial dystonia (HP:0012179)2.22369412
83Morphological abnormality of the pyramidal tract (HP:0002062)2.21876109
84Amyotrophic lateral sclerosis (HP:0007354)2.21604243
85Lower limb muscle weakness (HP:0007340)2.20969290
86Obstructive sleep apnea (HP:0002870)2.18461664
87Peripheral hypomyelination (HP:0007182)2.17833460
88Impaired vibratory sensation (HP:0002495)2.17468947
89Epileptiform EEG discharges (HP:0011182)2.16556092
90EEG with generalized epileptiform discharges (HP:0011198)2.16127891
91Limb dystonia (HP:0002451)2.15895177
92Anosmia (HP:0000458)2.12768259
93Hypsarrhythmia (HP:0002521)2.11695468
94Clonus (HP:0002169)2.10571229
95Abnormality of saccadic eye movements (HP:0000570)2.07040912
96Overgrowth (HP:0001548)2.06306187
97Fetal akinesia sequence (HP:0001989)2.03761168
98Neuronal loss in central nervous system (HP:0002529)2.02263065
99Deep palmar crease (HP:0006191)2.02156715
100Absent speech (HP:0001344)2.01146268
101Gait imbalance (HP:0002141)2.00622448
102Gait ataxia (HP:0002066)1.98581489
103Akinesia (HP:0002304)1.98325005
104Pheochromocytoma (HP:0002666)1.98219930
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95609841
106Hand muscle atrophy (HP:0009130)1.93621497
107Generalized myoclonic seizures (HP:0002123)1.93090003
108Tetraplegia (HP:0002445)1.92959594
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.92207723
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92207723
111Aplasia involving bones of the extremities (HP:0009825)1.91405570
112Aplasia involving bones of the upper limbs (HP:0009823)1.91405570
113Aplasia of the phalanges of the hand (HP:0009802)1.91405570
114Growth hormone deficiency (HP:0000824)1.90900535
115Apathy (HP:0000741)1.89505286
116Incomplete penetrance (HP:0003829)1.89399504
117Lower limb asymmetry (HP:0100559)1.88533808
118Double outlet right ventricle (HP:0001719)1.86984879
119Congenital malformation of the right heart (HP:0011723)1.86984879
120Hyperacusis (HP:0010780)1.86582229
121Spinal canal stenosis (HP:0003416)1.85725353
122Abnormal EKG (HP:0003115)1.82752926
123Polyphagia (HP:0002591)1.82691004
124Inappropriate behavior (HP:0000719)1.81934754
125Failure to thrive in infancy (HP:0001531)1.81286063
126Prolonged QT interval (HP:0001657)1.80556589
127Ankyloglossia (HP:0010296)1.79168949
128Hypoplasia of the brainstem (HP:0002365)1.79119046
129Aplasia/Hypoplasia of the brainstem (HP:0007362)1.79119046
130Postural tremor (HP:0002174)1.78896205
131Lower limb amyotrophy (HP:0007210)1.77982805
132CNS hypomyelination (HP:0003429)1.77949780
133Hypoplasia of the corpus callosum (HP:0002079)1.77384644
134Elfin facies (HP:0004428)1.77217692
135Rigidity (HP:0002063)1.75002295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.07633628
2MAP3K93.94750951
3EPHA43.84022410
4MARK13.63403045
5MAP3K42.87650652
6MINK12.76288253
7PAK62.73792722
8DAPK22.60575931
9PRKD32.56843855
10CAMKK12.33222861
11NTRK22.22393605
12MAP2K72.21412902
13KSR21.96022386
14NTRK11.88444526
15MAP2K41.75605974
16STK381.69651087
17CDK51.65329321
18SIK21.64343142
19UHMK11.55449319
20KSR11.52745707
21RIPK41.51680978
22TYRO31.43150684
23TAOK11.42407714
24CDK191.42260048
25GRK51.29134748
26TNIK1.28268192
27CAMKK21.27372235
28MAPK131.24297195
29MAP3K111.23790993
30DAPK11.23285134
31RIPK11.23192481
32DYRK21.21247550
33FES1.21191185
34PNCK1.20390724
35DYRK1B1.19420698
36PRKCG1.17420644
37STK111.15989114
38PRPF4B1.15356033
39BRAF1.15298522
40MAP3K121.13122638
41PHKG21.10185526
42PHKG11.10185526
43ALK1.09126693
44MAP3K21.08934220
45LATS21.06968407
46CAMK1D1.04621581
47PLK21.04085136
48CAMK11.03521937
49PRKCH1.00000270
50CDK150.99410264
51CDK180.98701233
52WNK10.96488754
53PINK10.96268408
54SGK2230.92400017
55SGK4940.92400017
56CDK140.92062245
57RET0.91629384
58MARK20.89593375
59LIMK10.89073264
60WNK40.88580315
61CDK11A0.87376633
62LMTK20.81116196
63PAK30.80134722
64MAP3K130.79546617
65CAMK2A0.77741418
66ARAF0.76913948
67CASK0.73020396
68CAMK1G0.72365663
69DYRK1A0.70960433
70CDC42BPA0.70440778
71SGK30.70084941
72OXSR10.67726508
73PDK10.65830870
74SGK20.64902807
75SGK10.64765538
76CSNK1G20.64540438
77SCYL20.63444441
78BRSK10.63217445
79PDPK10.62011881
80CAMK2B0.60934438
81TNK20.58777728
82DYRK30.57961008
83NEK60.57640919
84EPHB20.57620158
85PRKCZ0.56928376
86ERBB20.56135859
87RPS6KA30.54487188
88ADRBK20.54307996
89ICK0.53970572
90CSNK1E0.53904326
91TESK10.53668591
92FYN0.53172756
93CAMK40.52316968
94MAP3K10.51950337
95RAF10.51429629
96MAPK100.51022553
97MAPK120.50678395
98MAP3K70.46115445
99CAMK2G0.42794580
100FGFR20.42709532
101PRKACA0.42620274
102PTK2B0.41272167
103NEK10.40558044
104PRKG10.37082701
105DAPK30.36785818
106ROCK20.36528419
107BMPR20.35791836
108PDGFRA0.35452865
109PKN10.35063875
110PRKAA10.34878803
111PRKCE0.34124745
112GSK3B0.33988493
113DMPK0.33538590
114PRKCA0.33251075
115PRKCB0.32283970
116CAMK2D0.31965688
117RPS6KA20.30895885
118ROCK10.30446297
119MAPK80.29901362
120CSNK1A10.29371134
121BRD40.28706976
122PRKD10.28422141
123BMPR1B0.27709106

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.43494591
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19158263
3GABAergic synapse_Homo sapiens_hsa047272.66531174
4Olfactory transduction_Homo sapiens_hsa047402.65678720
5Glutamatergic synapse_Homo sapiens_hsa047242.63325937
6Circadian entrainment_Homo sapiens_hsa047132.62601760
7Long-term potentiation_Homo sapiens_hsa047202.53168342
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49221767
9Morphine addiction_Homo sapiens_hsa050322.40224312
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36251304
11Amphetamine addiction_Homo sapiens_hsa050312.26604291
12Salivary secretion_Homo sapiens_hsa049702.15871604
13Dopaminergic synapse_Homo sapiens_hsa047282.10403925
14Insulin secretion_Homo sapiens_hsa049112.03918269
15Gastric acid secretion_Homo sapiens_hsa049711.96214329
16Cholinergic synapse_Homo sapiens_hsa047251.91974920
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85616778
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78313997
19Nitrogen metabolism_Homo sapiens_hsa009101.70579166
20Long-term depression_Homo sapiens_hsa047301.68157257
21Taste transduction_Homo sapiens_hsa047421.66859147
22Cocaine addiction_Homo sapiens_hsa050301.63130236
23Oxytocin signaling pathway_Homo sapiens_hsa049211.62994491
24Renin secretion_Homo sapiens_hsa049241.54864672
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52704860
26Calcium signaling pathway_Homo sapiens_hsa040201.47047312
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46489864
28Serotonergic synapse_Homo sapiens_hsa047261.44074951
29GnRH signaling pathway_Homo sapiens_hsa049121.42549318
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40540503
31Type II diabetes mellitus_Homo sapiens_hsa049301.40382279
32Gap junction_Homo sapiens_hsa045401.38126007
33cAMP signaling pathway_Homo sapiens_hsa040241.29796757
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29663947
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20087376
36Estrogen signaling pathway_Homo sapiens_hsa049151.19010765
37Axon guidance_Homo sapiens_hsa043601.18683232
38Glioma_Homo sapiens_hsa052141.15124412
39ErbB signaling pathway_Homo sapiens_hsa040121.05305259
40Oxidative phosphorylation_Homo sapiens_hsa001901.04245629
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03359144
42Melanogenesis_Homo sapiens_hsa049161.02356711
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02308703
44Alzheimers disease_Homo sapiens_hsa050100.94991164
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.94841133
46Pancreatic secretion_Homo sapiens_hsa049720.93192920
47Parkinsons disease_Homo sapiens_hsa050120.92913934
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92173564
49Vitamin B6 metabolism_Homo sapiens_hsa007500.91375452
50Dorso-ventral axis formation_Homo sapiens_hsa043200.91167728
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90188656
52Oocyte meiosis_Homo sapiens_hsa041140.87755264
53Cardiac muscle contraction_Homo sapiens_hsa042600.86681469
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.86556926
55Fatty acid biosynthesis_Homo sapiens_hsa000610.85958808
56Collecting duct acid secretion_Homo sapiens_hsa049660.85767485
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85254214
58Thyroid hormone synthesis_Homo sapiens_hsa049180.82810081
59Phototransduction_Homo sapiens_hsa047440.82686473
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81707577
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80636674
62Dilated cardiomyopathy_Homo sapiens_hsa054140.74750944
63Choline metabolism in cancer_Homo sapiens_hsa052310.74724451
64MAPK signaling pathway_Homo sapiens_hsa040100.74520316
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.72699561
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69693283
67VEGF signaling pathway_Homo sapiens_hsa043700.69365405
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67690968
69Bile secretion_Homo sapiens_hsa049760.65609475
70mTOR signaling pathway_Homo sapiens_hsa041500.64470610
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64180518
72Endocytosis_Homo sapiens_hsa041440.63106793
73Rap1 signaling pathway_Homo sapiens_hsa040150.60256430
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.59943988
75Huntingtons disease_Homo sapiens_hsa050160.58949507
76Ras signaling pathway_Homo sapiens_hsa040140.57294559
77Endometrial cancer_Homo sapiens_hsa052130.57155306
78Inositol phosphate metabolism_Homo sapiens_hsa005620.56596599
79Vibrio cholerae infection_Homo sapiens_hsa051100.56085259
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55071538
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53911926
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53155824
83Glucagon signaling pathway_Homo sapiens_hsa049220.52891087
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52068470
85Renal cell carcinoma_Homo sapiens_hsa052110.50900723
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50863520
87Alcoholism_Homo sapiens_hsa050340.50790902
88Non-small cell lung cancer_Homo sapiens_hsa052230.49898205
89Type I diabetes mellitus_Homo sapiens_hsa049400.49838484
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48272250
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46623713
92Wnt signaling pathway_Homo sapiens_hsa043100.45445786
93Circadian rhythm_Homo sapiens_hsa047100.44770576
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43365752
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43208704
96Notch signaling pathway_Homo sapiens_hsa043300.43090679
97Insulin signaling pathway_Homo sapiens_hsa049100.43050878
98Chemokine signaling pathway_Homo sapiens_hsa040620.41588462
99Regulation of autophagy_Homo sapiens_hsa041400.40780751
100Prion diseases_Homo sapiens_hsa050200.39659760
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36727807
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36528293
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36281849
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36096580
105Hedgehog signaling pathway_Homo sapiens_hsa043400.35422191
106Hippo signaling pathway_Homo sapiens_hsa043900.35407639
107Arginine and proline metabolism_Homo sapiens_hsa003300.33916068
108Ovarian steroidogenesis_Homo sapiens_hsa049130.33498029
109Colorectal cancer_Homo sapiens_hsa052100.31881165
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.30453183
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29612688
112Prolactin signaling pathway_Homo sapiens_hsa049170.28272721
113AMPK signaling pathway_Homo sapiens_hsa041520.26928215
114Platelet activation_Homo sapiens_hsa046110.26842728

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »