SCTR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurotransmitter catabolic process (GO:0042135)8.15544415
2behavioral response to ethanol (GO:0048149)7.70650027
3norepinephrine metabolic process (GO:0042415)7.35847583
4catechol-containing compound biosynthetic process (GO:0009713)7.09536948
5catecholamine biosynthetic process (GO:0042423)7.09536948
6dopamine metabolic process (GO:0042417)7.01574077
7calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.69418691
8catecholamine transport (GO:0051937)6.66277348
9synaptic transmission, cholinergic (GO:0007271)6.49154801
10positive regulation of potassium ion transmembrane transporter activity (GO:1901018)6.05298743
11response to water (GO:0009415)5.97215902
12maternal behavior (GO:0042711)5.96645260
13cellular response to nicotine (GO:0071316)5.89313452
14positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.66755286
15short-chain fatty acid metabolic process (GO:0046459)5.61787798
16sodium-independent organic anion transport (GO:0043252)5.42361000
17negative regulation of microtubule polymerization (GO:0031115)5.35843647
18alkaloid metabolic process (GO:0009820)5.25439215
19parental behavior (GO:0060746)5.23175923
20dopamine biosynthetic process (GO:0042416)5.07614559
21oxygen transport (GO:0015671)5.00215744
22catechol-containing compound metabolic process (GO:0009712)4.95450809
23catecholamine metabolic process (GO:0006584)4.95450809
24neuromuscular synaptic transmission (GO:0007274)4.92983182
25response to pain (GO:0048265)4.89557254
26positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.89182120
27regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.89182120
28regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.80318900
29cellular response to nerve growth factor stimulus (GO:1990090)4.80185352
30response to nerve growth factor (GO:1990089)4.80185352
31transepithelial transport (GO:0070633)4.77145376
32regulation of secondary heart field cardioblast proliferation (GO:0003266)4.76751099
33regulation of cardioblast proliferation (GO:0003264)4.76751099
34cell migration in hindbrain (GO:0021535)4.72916168
35dopaminergic neuron differentiation (GO:0071542)4.65637294
36neurotransmitter biosynthetic process (GO:0042136)4.42629613
37benzene-containing compound metabolic process (GO:0042537)4.37293028
38regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.29887796
39regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.29887796
40lung vasculature development (GO:0060426)4.28256518
41response to hepatocyte growth factor (GO:0035728)4.17047369
42cellular response to hepatocyte growth factor stimulus (GO:0035729)4.17047369
43phenol-containing compound biosynthetic process (GO:0046189)4.15485249
44water-soluble vitamin biosynthetic process (GO:0042364)4.09834134
45proline transport (GO:0015824)4.09611419
46monoamine transport (GO:0015844)4.01554744
47ganglion development (GO:0061548)3.99455607
48enteric nervous system development (GO:0048484)3.96288800
49negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.89540245
50activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.88930745
51response to amphetamine (GO:0001975)3.86504554
52coronary vasculature morphogenesis (GO:0060977)3.86249152
53regulation of respiratory gaseous exchange (GO:0043576)3.86244289
54response to nicotine (GO:0035094)3.81007338
55fatty acid derivative transport (GO:1901571)3.77431454
56icosanoid transport (GO:0071715)3.77431454
57detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.76570876
58detection of temperature stimulus involved in sensory perception (GO:0050961)3.76570876
59regulation of hexokinase activity (GO:1903299)3.72332088
60regulation of glucokinase activity (GO:0033131)3.72332088
61indole-containing compound catabolic process (GO:0042436)3.53867474
62indolalkylamine catabolic process (GO:0046218)3.53867474
63tryptophan catabolic process (GO:0006569)3.53867474
64positive regulation of potassium ion transmembrane transport (GO:1901381)3.51515783
65lung lobe morphogenesis (GO:0060463)3.51138372
66positive regulation of protein kinase C signaling (GO:0090037)3.48832568
67regulation of acrosome reaction (GO:0060046)3.48348057
68regulation of vesicle fusion (GO:0031338)3.47519827
69muscle organ morphogenesis (GO:0048644)3.42072816
70chemical homeostasis within a tissue (GO:0048875)3.40379624
71nerve growth factor signaling pathway (GO:0038180)3.39946852
72surfactant homeostasis (GO:0043129)3.39451411
73detection of temperature stimulus (GO:0016048)3.38585022
74intestinal cholesterol absorption (GO:0030299)3.37622788
75adult feeding behavior (GO:0008343)3.35784555
76nucleobase catabolic process (GO:0046113)3.32523789
77regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.32010100
78positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.29531068
79toxin metabolic process (GO:0009404)3.27773927
80positive regulation of metanephros development (GO:0072216)3.27352214
81positive regulation of vesicle fusion (GO:0031340)3.27106691
82neurotransmitter metabolic process (GO:0042133)3.25862458
83glycine transport (GO:0015816)3.23949188
84mast cell activation involved in immune response (GO:0002279)3.23635943
85mast cell degranulation (GO:0043303)3.23635943
86multi-organism reproductive behavior (GO:0044705)3.22913689
87neurotransmitter secretion (GO:0007269)3.22890397
88alanine transport (GO:0032328)3.22487554
89negative regulation of striated muscle cell apoptotic process (GO:0010664)3.22060628
90negative regulation of JUN kinase activity (GO:0043508)3.21966429
91auditory receptor cell differentiation (GO:0042491)3.21677109
92regulation of neurotransmitter transport (GO:0051588)3.19674837
93regulation of oxidative phosphorylation (GO:0002082)3.17544550
94cellular biogenic amine catabolic process (GO:0042402)3.16818449
95amine catabolic process (GO:0009310)3.16818449
96regulation of neurotransmitter uptake (GO:0051580)3.16038382
97parturition (GO:0007567)3.13995028
98actin filament depolymerization (GO:0030042)3.13660427
99fibroblast migration (GO:0010761)3.13293500
100cobalamin metabolic process (GO:0009235)3.13288463
101negative regulation of complement activation (GO:0045916)3.13095337
102multicellular organismal reproductive behavior (GO:0033057)3.11763436
103positive regulation of neurotransmitter transport (GO:0051590)3.10345350
104phasic smooth muscle contraction (GO:0014821)3.08032416
105aromatic amino acid family catabolic process (GO:0009074)3.06573103
106mating behavior (GO:0007617)3.04933920
107endocrine pancreas development (GO:0031018)3.04694167
108tryptophan metabolic process (GO:0006568)3.03666611
109neurotransmitter transport (GO:0006836)3.03194514
110indolalkylamine metabolic process (GO:0006586)3.01818750
111mannosylation (GO:0097502)3.01698207
112reproductive behavior (GO:0019098)3.01644361
113regulation of synaptic transmission, dopaminergic (GO:0032225)3.00532091
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99861964
115* digestion (GO:0007586)2.96495488
116platelet dense granule organization (GO:0060155)2.94481084
117response to insecticide (GO:0017085)2.91850061
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91677855
119negative regulation of protein activation cascade (GO:2000258)2.91406598
120respiratory chain complex IV assembly (GO:0008535)2.91095717
121regulation of neurotransmitter secretion (GO:0046928)2.90581957
122phosphatidylethanolamine metabolic process (GO:0046337)2.89673013
123gas transport (GO:0015669)2.89064568
124regulation of response to food (GO:0032095)2.88904136
125dopamine transport (GO:0015872)2.87154965
126tyrosine phosphorylation of STAT protein (GO:0007260)2.86406990
127negative regulation of neurological system process (GO:0031645)2.84971855
128drug catabolic process (GO:0042737)2.83258919
129mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81107705
130phosphatidylethanolamine biosynthetic process (GO:0006646)2.80928888
131serotonin receptor signaling pathway (GO:0007210)2.80903146
132glycerophospholipid catabolic process (GO:0046475)2.80163151
133myelin assembly (GO:0032288)2.79610382
134G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.78950206
135positive regulation of glycolytic process (GO:0045821)2.78453398
136vesicle transport along microtubule (GO:0047496)2.77875941
137response to amine (GO:0014075)2.77569386
138outflow tract septum morphogenesis (GO:0003148)2.77023349
139xenobiotic catabolic process (GO:0042178)2.74792445
140L-fucose metabolic process (GO:0042354)2.73940760
141L-fucose catabolic process (GO:0042355)2.73940760
142fucose catabolic process (GO:0019317)2.73940760
143regulation of neurotransmitter levels (GO:0001505)2.73498637
144cytochrome complex assembly (GO:0017004)2.72312277
145aldehyde catabolic process (GO:0046185)2.72005271
146cardiac chamber formation (GO:0003207)2.70817301
147L-ascorbic acid metabolic process (GO:0019852)2.70461234
148positive regulation of protein depolymerization (GO:1901881)2.69386379
149positive regulation of transcription regulatory region DNA binding (GO:2000679)2.68491243
150primary amino compound metabolic process (GO:1901160)2.68485934
151electron transport chain (GO:0022900)2.68168835
152regulation of short-term neuronal synaptic plasticity (GO:0048172)2.67498784
153regulation of energy homeostasis (GO:2000505)2.67118908
154negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66170010
155tyrosine metabolic process (GO:0006570)2.65957551
156nephron tubule morphogenesis (GO:0072078)2.65430243
157nephron epithelium morphogenesis (GO:0072088)2.65430243
158regulation of calcium ion-dependent exocytosis (GO:0017158)2.64601867
159spinal cord motor neuron differentiation (GO:0021522)2.63477605
160atrial cardiac muscle cell action potential (GO:0086014)2.62113924
161cellular ketone body metabolic process (GO:0046950)2.61772408
162regulation of microtubule polymerization (GO:0031113)2.61457813
163ATP synthesis coupled proton transport (GO:0015986)2.59882820
164energy coupled proton transport, down electrochemical gradient (GO:0015985)2.59882820
165kynurenine metabolic process (GO:0070189)2.59597837
166cellular copper ion homeostasis (GO:0006878)2.59350083
167multicellular organismal response to stress (GO:0033555)2.59293844
168positive regulation of astrocyte differentiation (GO:0048711)2.59086791
169maintenance of gastrointestinal epithelium (GO:0030277)2.58704169
170piRNA metabolic process (GO:0034587)2.58081702
171positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.57958795
172positive regulation of calcium ion import (GO:0090280)2.56297871
173mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.56197810
174cellular response to nitric oxide (GO:0071732)2.55547419
175intraciliary transport (GO:0042073)2.55533578
176nitric oxide mediated signal transduction (GO:0007263)2.54201693
177L-phenylalanine catabolic process (GO:0006559)2.53366935
178erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.53366935
179cellular extravasation (GO:0045123)2.50608923
180glucuronate metabolic process (GO:0019585)2.50013989
181uronic acid metabolic process (GO:0006063)2.50013989
182protein K11-linked deubiquitination (GO:0035871)2.49819887
183reflex (GO:0060004)2.48860029
184detection of light stimulus involved in sensory perception (GO:0050962)2.48055885
185detection of light stimulus involved in visual perception (GO:0050908)2.48055885
186regulation of metanephros development (GO:0072215)2.47481196
187photoreceptor cell maintenance (GO:0045494)2.47322054
188one-carbon compound transport (GO:0019755)2.44895565
189single strand break repair (GO:0000012)2.44165008
190axoneme assembly (GO:0035082)2.42560938
191auditory receptor cell stereocilium organization (GO:0060088)2.42155848
192regulation of triglyceride biosynthetic process (GO:0010866)2.40219177
193thyroid hormone metabolic process (GO:0042403)2.39762590
194regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.39093687
195tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37978917
196phenol-containing compound catabolic process (GO:0019336)17.5789349
197behavioral response to nicotine (GO:0035095)11.4714795
198sympathetic nervous system development (GO:0048485)10.6725818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.86778176
2NR3C1_23031785_ChIP-Seq_PC12_Mouse3.79609357
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.73016044
4EZH2_22144423_ChIP-Seq_EOC_Human3.55677907
5ZNF274_21170338_ChIP-Seq_K562_Hela3.01789387
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90029878
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77822209
8ZNF263_19887448_ChIP-Seq_K562_Human2.70823794
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.67685472
10VDR_22108803_ChIP-Seq_LS180_Human2.61133642
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54111421
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50514062
13TAF15_26573619_Chip-Seq_HEK293_Human2.43812250
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38626503
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33066440
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.28959734
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27462988
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25275678
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25172787
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25172787
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.20525472
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17732509
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14013199
24EGR1_23403033_ChIP-Seq_LIVER_Mouse2.10556370
25AR_21572438_ChIP-Seq_LNCaP_Human2.09921860
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.09712263
27ERG_21242973_ChIP-ChIP_JURKAT_Human2.09264038
28CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02213778
29JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00530872
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98898780
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91984706
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91831697
33REST_21632747_ChIP-Seq_MESCs_Mouse1.87303420
34BCAT_22108803_ChIP-Seq_LS180_Human1.86019039
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85225924
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.82611159
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.76636252
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.74714948
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.73642241
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.70877048
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69602804
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.69284885
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66283325
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64299333
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.61992954
46CBP_20019798_ChIP-Seq_JUKART_Human1.61572242
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61572242
48* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61260748
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59923637
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59332771
51IGF1R_20145208_ChIP-Seq_DFB_Human1.57904665
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54128719
53* EZH2_27294783_Chip-Seq_ESCs_Mouse1.53220658
54GBX2_23144817_ChIP-Seq_PC3_Human1.51594394
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48998643
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45655082
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.44917295
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41379535
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41370956
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.39700924
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36596991
62CLOCK_20551151_ChIP-Seq_293T_Human1.36397316
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35956721
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35325923
65STAT3_23295773_ChIP-Seq_U87_Human1.34898769
66P300_19829295_ChIP-Seq_ESCs_Human1.34288535
67AR_25329375_ChIP-Seq_VCAP_Human1.33808121
68CDX2_22108803_ChIP-Seq_LS180_Human1.31789621
69* GATA3_21878914_ChIP-Seq_MCF-7_Human1.31098562
70* TCF4_23295773_ChIP-Seq_U87_Human1.30620741
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28262367
72CDX2_20551321_ChIP-Seq_CACO-2_Human1.27171088
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26472362
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.26060688
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24694731
76* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23482195
77HOXB7_26014856_ChIP-Seq_BT474_Human1.23363407
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.22949009
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22089581
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.22043964
81TP53_22573176_ChIP-Seq_HFKS_Human1.21407001
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.21243130
83GATA4_25053715_ChIP-Seq_YYC3_Human1.21179744
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20913666
85SOX2_19829295_ChIP-Seq_ESCs_Human1.20648927
86NANOG_19829295_ChIP-Seq_ESCs_Human1.20648927
87SMAD4_21799915_ChIP-Seq_A2780_Human1.20242002
88AHR_22903824_ChIP-Seq_MCF-7_Human1.20129577
89FUS_26573619_Chip-Seq_HEK293_Human1.19556956
90FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19302881
91FOXA1_25329375_ChIP-Seq_VCAP_Human1.19302881
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17537509
93ER_23166858_ChIP-Seq_MCF-7_Human1.16824760
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16178213
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16150747
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14376582
97EWS_26573619_Chip-Seq_HEK293_Human1.11584045
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11428728
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.11195053
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11054992
101CJUN_26792858_Chip-Seq_BT549_Human1.10851961
102AR_20517297_ChIP-Seq_VCAP_Human1.10636249
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.10576940
104PHF8_20622853_ChIP-Seq_HELA_Human1.10078592
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08467326
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08406338
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07814175
108SOX2_20726797_ChIP-Seq_SW620_Human1.07733859
109ERA_21632823_ChIP-Seq_H3396_Human1.07512884
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.07396410
111JUN_21703547_ChIP-Seq_K562_Human1.06324749
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06286394
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06143400
114TCF4_22108803_ChIP-Seq_LS180_Human1.05872209
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05147128
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05112346
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04206530
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04184495
119SMAD4_21741376_ChIP-Seq_HESCs_Human1.04103315
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04013102
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03474945
122* EZH2_27294783_Chip-Seq_NPCs_Mouse1.03398563
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.03261779
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02585659
125ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02278911
126TP53_16413492_ChIP-PET_HCT116_Human1.02241208
127SOX2_21211035_ChIP-Seq_LN229_Gbm1.01937458
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01352015
129CTCF_27219007_Chip-Seq_Bcells_Human1.01297212
130PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00991433
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00672797
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00515760
133NFYB_21822215_ChIP-Seq_K562_Human0.99795685
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98783212
135TBL1_22424771_ChIP-Seq_293T_Human0.98491455
136DROSHA_22980978_ChIP-Seq_HELA_Human0.97545826
137ETV1_20927104_ChIP-Seq_GIST48_Human0.97249625
138CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97129084
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97002480
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.96386570
141CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95785537
142FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95638903
143RBPJ_21746931_ChIP-Seq_IB4_Human0.95413612
144AR_21909140_ChIP-Seq_LNCAP_Human0.95102396
145POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94849938
146PRDM14_20953172_ChIP-Seq_ESCs_Human0.94838197
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94337220
148FOXA2_19822575_ChIP-Seq_HepG2_Human0.94330530
149OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93906828
150NCOR_22424771_ChIP-Seq_293T_Human0.93709834
151* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93351974
152RARB_27405468_Chip-Seq_BRAIN_Mouse0.93138254
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92502154
154TAF2_19829295_ChIP-Seq_ESCs_Human0.92385628
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91808661
156WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89172458
157EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88379151
158PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.87337959
159RUNX2_22187159_ChIP-Seq_PCA_Human0.86807554
160ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85693420
161EOMES_21245162_ChIP-Seq_HESCs_Human0.84736813
162NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82703412
163NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82703412
164ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81310882
165CBX2_27304074_Chip-Seq_ESCs_Mouse0.81009323
166KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80434793
167SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78197054
168CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76932203
169RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76455184
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.76257757
171FOXO3_23340844_ChIP-Seq_DLD1_Human0.76247155
172ZFP281_18757296_ChIP-ChIP_E14_Mouse0.75629028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex5.55928549
2MP0010386_abnormal_urinary_bladder5.55304626
3MP0003136_yellow_coat_color4.66959292
4MP0003195_calcinosis3.99822942
5MP0003300_gastrointestinal_ulcer3.70915556
6MP0001905_abnormal_dopamine_level3.29550118
7MP0009840_abnormal_foam_cell3.27285977
8MP0002138_abnormal_hepatobiliary_system3.08591905
9MP0004270_analgesia3.08308431
10MP0001529_abnormal_vocalization3.03671078
11MP0003252_abnormal_bile_duct2.94671049
12MP0005365_abnormal_bile_salt2.92513734
13MP0000538_abnormal_urinary_bladder2.86390448
14MP0000372_irregular_coat_pigmentation2.80461977
15MP0004858_abnormal_nervous_system2.70898458
16MP0008875_abnormal_xenobiotic_pharmacok2.67693387
17MP0006276_abnormal_autonomic_nervous2.65761654
18MP0002751_abnormal_autonomic_nervous2.62781387
19MP0001440_abnormal_grooming_behavior2.53349459
20MP0002928_abnormal_bile_duct2.50217883
21MP0002734_abnormal_mechanical_nocicepti2.31403107
22MP0008872_abnormal_physiological_respon2.28962172
23MP0005084_abnormal_gallbladder_morpholo2.28285047
24MP0009745_abnormal_behavioral_response2.27028363
25MP0001666_abnormal_nutrient_absorption2.22225295
26MP0002733_abnormal_thermal_nociception2.19478333
27MP0002876_abnormal_thyroid_physiology2.19215318
28MP0001970_abnormal_pain_threshold2.17045968
29MP0005220_abnormal_exocrine_pancreas2.11726615
30MP0002822_catalepsy11.7597157
31MP0002102_abnormal_ear_morphology1.98182824
32MP0005174_abnormal_tail_pigmentation1.90873958
33MP0002132_abnormal_respiratory_system1.89447620
34MP0003646_muscle_fatigue1.81891666
35MP0004924_abnormal_behavior1.81347914
36MP0005386_behavior/neurological_phenoty1.81347914
37MP0004043_abnormal_pH_regulation1.71284888
38MP0001501_abnormal_sleep_pattern1.66452333
39MP0010329_abnormal_lipoprotein_level1.65472152
40MP0003011_delayed_dark_adaptation1.65051808
41MP0009379_abnormal_foot_pigmentation1.64139176
42MP0001944_abnormal_pancreas_morphology1.62856884
43MP0000015_abnormal_ear_pigmentation1.61910929
44MP0000383_abnormal_hair_follicle1.60550884
45MP0005551_abnormal_eye_electrophysiolog1.60071208
46MP0003635_abnormal_synaptic_transmissio1.55450988
47MP0005197_abnormal_uvea_morphology1.53663013
48MP0002277_abnormal_respiratory_mucosa1.52911963
49MP0003279_aneurysm1.50034286
50MP0002064_seizures1.47412399
51MP0003633_abnormal_nervous_system1.47378986
52MP0005410_abnormal_fertilization1.44124507
53MP0004859_abnormal_synaptic_plasticity1.42690070
54MP0002572_abnormal_emotion/affect_behav1.41064933
55MP0008995_early_reproductive_senescence1.38571149
56MP0002127_abnormal_cardiovascular_syste1.37261010
57MP0002163_abnormal_gland_morphology1.36076919
58MP0010678_abnormal_skin_adnexa1.33512729
59MP0000751_myopathy1.33266995
60MP0003283_abnormal_digestive_organ1.32487854
61MP0001485_abnormal_pinna_reflex1.30006171
62MP0000462_abnormal_digestive_system1.29005565
63MP0005085_abnormal_gallbladder_physiolo1.26435614
64MP0002837_dystrophic_cardiac_calcinosis1.26235244
65MP0001984_abnormal_olfaction1.24995664
66MP0005408_hypopigmentation1.24729694
67MP0003631_nervous_system_phenotype1.18007613
68MP0008569_lethality_at_weaning1.16327992
69MP0002118_abnormal_lipid_homeostasis1.14312641
70MP0005448_abnormal_energy_balance1.13037948
71MP0002063_abnormal_learning/memory/cond1.12358325
72MP0004782_abnormal_surfactant_physiolog1.12262036
73MP0002272_abnormal_nervous_system1.11764262
74MP0005646_abnormal_pituitary_gland1.11403974
75MP0002693_abnormal_pancreas_physiology1.10621178
76MP0003866_abnormal_defecation1.09738058
77MP0000013_abnormal_adipose_tissue1.09459861
78MP0004233_abnormal_muscle_weight1.08890816
79MP0004381_abnormal_hair_follicle1.08552534
80* MP0009643_abnormal_urine_homeostasis1.07442832
81MP0002909_abnormal_adrenal_gland1.04987899
82MP0003656_abnormal_erythrocyte_physiolo1.03448420
83MP0005253_abnormal_eye_physiology1.03394241
84MP0001764_abnormal_homeostasis1.02550571
85MP0005535_abnormal_body_temperature1.00876804
86MP0002184_abnormal_innervation0.98668659
87MP0000749_muscle_degeneration0.98148662
88MP0005645_abnormal_hypothalamus_physiol0.97099394
89MP0004134_abnormal_chest_morphology0.94800234
90MP0008874_decreased_physiological_sensi0.94310238
91MP0005379_endocrine/exocrine_gland_phen0.93392505
92MP0004019_abnormal_vitamin_homeostasis0.92092334
93MP0002139_abnormal_hepatobiliary_system0.91208346
94MP0003943_abnormal_hepatobiliary_system0.90646015
95MP0000747_muscle_weakness0.88094602
96MP0003045_fibrosis0.87429264
97MP0001324_abnormal_eye_pigmentation0.84948854
98MP0000631_abnormal_neuroendocrine_gland0.83734339
99MP0004147_increased_porphyrin_level0.82796595
100* MP0002078_abnormal_glucose_homeostasis0.81918028
101MP0000778_abnormal_nervous_system0.81051112
102MP0002095_abnormal_skin_pigmentation0.80745547
103MP0003329_amyloid_beta_deposits0.80428370
104MP0005167_abnormal_blood-brain_barrier0.79560319
105MP0004885_abnormal_endolymph0.77834513
106MP0008004_abnormal_stomach_pH0.77359572
107MP0002168_other_aberrant_phenotype0.76586145
108MP0004133_heterotaxia0.76077323
109MP0002160_abnormal_reproductive_system0.75785444
110MP0005083_abnormal_biliary_tract0.75694630
111MP0004142_abnormal_muscle_tone0.74480419
112MP0002735_abnormal_chemical_nociception0.72681214
113MP0002067_abnormal_sensory_capabilities0.71852787
114MP0001340_abnormal_eyelid_morphology0.71782101
115MP0002089_abnormal_postnatal_growth/wei0.71187184
116MP0005195_abnormal_posterior_eye0.69888653
117MP0004811_abnormal_neuron_physiology0.68623022
118MP0002557_abnormal_social/conspecific_i0.67319554
119MP0002066_abnormal_motor_capabilities/c0.66988540
120MP0000955_abnormal_spinal_cord0.66905625
121MP0005636_abnormal_mineral_homeostasis0.66822706
122* MP0002136_abnormal_kidney_physiology0.65804161
123MP0001486_abnormal_startle_reflex0.65566729
124MP0000470_abnormal_stomach_morphology0.65392423
125MP0001270_distended_abdomen0.65296029
126MP0000569_abnormal_digit_pigmentation0.65219171
127MP0002090_abnormal_vision0.65082728
128MP0003122_maternal_imprinting0.64962242
129MP0003959_abnormal_lean_body0.63847546
130MP0005409_darkened_coat_color0.63725935
131MP0001968_abnormal_touch/_nociception0.63522814
132MP0005171_absent_coat_pigmentation0.63101147
133MP0005023_abnormal_wound_healing0.62930655
134MP0006138_congestive_heart_failure0.62731139
135* MP0002135_abnormal_kidney_morphology0.62350360
136MP0001958_emphysema0.61486233
137MP0002332_abnormal_exercise_endurance0.61339759
138* MP0001756_abnormal_urination0.60493171
139MP0001188_hyperpigmentation0.59574483
140MP0000049_abnormal_middle_ear0.59458919
141MP0001664_abnormal_digestion0.59012736
142MP0000759_abnormal_skeletal_muscle0.58488350
143MP0002882_abnormal_neuron_morphology0.58430023
144* MP0003953_abnormal_hormone_level0.58369128
145MP0004130_abnormal_muscle_cell0.57236319
146MP0006292_abnormal_olfactory_placode0.57083255
147MP0009046_muscle_twitch0.56828155
148MP0003632_abnormal_nervous_system0.55854066
149MP0005620_abnormal_muscle_contractility0.54377273
150MP0003942_abnormal_urinary_system0.54128658
151* MP0002069_abnormal_eating/drinking_beha0.52629283
152MP0005394_taste/olfaction_phenotype0.51776859
153MP0005499_abnormal_olfactory_system0.51776859
154MP0004085_abnormal_heartbeat0.50071841
155MP0008789_abnormal_olfactory_epithelium0.49733200
156MP0005623_abnormal_meninges_morphology0.47265882
157MP0002152_abnormal_brain_morphology0.47163864
158MP0005423_abnormal_somatic_nervous0.46542361
159MP0004272_abnormal_basement_membrane0.45686722
160MP0002752_abnormal_somatic_nervous0.45591080
161MP0005670_abnormal_white_adipose0.44798171
162MP0001881_abnormal_mammary_gland0.42861548
163MP0005332_abnormal_amino_acid0.40091165
164MP0009780_abnormal_chondrocyte_physiolo0.39794422
165MP0002106_abnormal_muscle_physiology0.38451397
166MP0001502_abnormal_circadian_rhythm0.38242344
167MP0006072_abnormal_retinal_apoptosis0.37957374
168MP0003567_abnormal_fetal_cardiomyocyte0.36844973
169MP0006036_abnormal_mitochondrial_physio0.35047416

Predicted human phenotypes

RankGene SetZ-score
1Neonatal hypoglycemia (HP:0001998)8.48654150
2Abnormal autonomic nervous system physiology (HP:0012332)8.23885777
3Myokymia (HP:0002411)6.48281444
4Amblyopia (HP:0000646)4.96655464
5Hypotension (HP:0002615)4.86115924
6Severe visual impairment (HP:0001141)4.78671615
7Exotropia (HP:0000577)4.55054825
8Limb dystonia (HP:0002451)4.51183770
9Autoamputation (HP:0001218)4.46327477
10Exocrine pancreatic insufficiency (HP:0001738)4.45841975
11Scotoma (HP:0000575)4.26718043
12Abnormal rod and cone electroretinograms (HP:0008323)4.20484209
13Myotonia (HP:0002486)4.17277186
14Abnormality of macular pigmentation (HP:0008002)3.82134420
15Cerebral palsy (HP:0100021)3.63663495
16Pancreatic cysts (HP:0001737)3.61728181
17Attenuation of retinal blood vessels (HP:0007843)3.56766790
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.50817336
19Arthropathy (HP:0003040)3.49596353
20Abnormality of the renal medulla (HP:0100957)3.48722913
21Impulsivity (HP:0100710)3.36900082
22Large for gestational age (HP:0001520)3.31830091
23Abnormality of the renal cortex (HP:0011035)3.31659127
24Tubulointerstitial fibrosis (HP:0005576)3.29542365
25Nephronophthisis (HP:0000090)3.21428327
26Abnormality of midbrain morphology (HP:0002418)3.18548379
27Molar tooth sign on MRI (HP:0002419)3.18548379
28Hypomagnesemia (HP:0002917)3.17008697
29Hyperthyroidism (HP:0000836)3.14147421
30Abnormality of the fovea (HP:0000493)3.09782324
31Type II lissencephaly (HP:0007260)3.05275355
32Recurrent corneal erosions (HP:0000495)3.00004614
33Tubular atrophy (HP:0000092)2.96317131
34External ophthalmoplegia (HP:0000544)2.94210701
35Tachypnea (HP:0002789)2.91951000
36Hypoventilation (HP:0002791)2.90721508
37Impaired pain sensation (HP:0007328)2.89168602
38Abnormality of pain sensation (HP:0010832)2.89168602
39Central scotoma (HP:0000603)2.88898333
40Severe Myopia (HP:0011003)2.83376004
41Azoospermia (HP:0000027)2.82795713
42Pancreatic fibrosis (HP:0100732)2.82559949
43Pheochromocytoma (HP:0002666)2.80827786
44True hermaphroditism (HP:0010459)2.80602980
45Polydipsia (HP:0001959)2.79558855
46Abnormal drinking behavior (HP:0030082)2.79558855
47Abnormality of chloride homeostasis (HP:0011422)2.78630121
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.71994625
49Ketoacidosis (HP:0001993)2.69331430
50Bony spicule pigmentary retinopathy (HP:0007737)2.65908364
51Focal motor seizures (HP:0011153)2.65494858
52Seborrheic dermatitis (HP:0001051)2.63751510
53Congenital stationary night blindness (HP:0007642)2.63589862
54Neuroendocrine neoplasm (HP:0100634)2.58279262
55Cystic liver disease (HP:0006706)2.56547516
56Tubulointerstitial abnormality (HP:0001969)2.53977958
57Rectal prolapse (HP:0002035)2.47773271
58Abnormal pupillary function (HP:0007686)2.47271052
59Dysautonomia (HP:0002459)2.43338304
60Duplicated collecting system (HP:0000081)2.43212617
61Ileus (HP:0002595)2.41958669
62Polyuria (HP:0000103)2.41277288
63Abnormality of the renal collecting system (HP:0004742)2.41006893
64Cerebellar dysplasia (HP:0007033)2.39163711
65Acute necrotizing encephalopathy (HP:0006965)2.38331350
66Steatorrhea (HP:0002570)2.37232573
67Clubbing of toes (HP:0100760)2.36530884
68Abnormality of urine glucose concentration (HP:0011016)2.31554165
69Glycosuria (HP:0003076)2.31554165
70Neonatal onset (HP:0003623)2.30188629
71Abnormality of magnesium homeostasis (HP:0004921)2.29790434
72Potter facies (HP:0002009)2.28754556
73Facial shape deformation (HP:0011334)2.28754556
74Hypoproteinemia (HP:0003075)2.28249026
75Late onset (HP:0003584)2.27882093
76Thyroid carcinoma (HP:0002890)2.27381634
77Episodic fever (HP:0001954)2.26764230
78Hyperventilation (HP:0002883)2.25962685
79Agitation (HP:0000713)2.25291009
80Abnormality of renal excretion (HP:0011036)2.25165832
81Limb hypertonia (HP:0002509)2.24284822
82Focal seizures (HP:0007359)2.23997677
83Fair hair (HP:0002286)2.22598852
84Progressive macrocephaly (HP:0004481)2.19420464
85Decreased central vision (HP:0007663)2.17875711
86Increased circulating renin level (HP:0000848)2.17341265
87Generalized tonic-clonic seizures (HP:0002069)2.16853731
88Hyperglycinemia (HP:0002154)2.16355189
89Glossoptosis (HP:0000162)2.15869000
90Abnormal pancreas size (HP:0012094)2.13846697
91Atonic seizures (HP:0010819)2.13546997
92Visual hallucinations (HP:0002367)2.12300735
93Hypoplasia of the uterus (HP:0000013)2.12022304
94Abnormal mitochondria in muscle tissue (HP:0008316)2.10494957
95Hyperinsulinemic hypoglycemia (HP:0000825)2.10089742
96Irregular vertebral endplates (HP:0003301)2.09948615
97Medial flaring of the eyebrow (HP:0010747)2.09073843
98Mitochondrial inheritance (HP:0001427)2.08636886
99Aplasia/hypoplasia of the uterus (HP:0008684)2.08069302
100Widely spaced teeth (HP:0000687)2.06762369
101Postural tremor (HP:0002174)2.06426086
102Action tremor (HP:0002345)2.04385190
103Pendular nystagmus (HP:0012043)2.04124186
104Sensory axonal neuropathy (HP:0003390)2.03221868
105Abnormal urine output (HP:0012590)2.03020360
106Anxiety (HP:0000739)2.03008749
107Hyperlipoproteinemia (HP:0010980)2.02467612
108Acute encephalopathy (HP:0006846)2.02142737
109Generalized aminoaciduria (HP:0002909)2.01727313
110Neoplasm of the lung (HP:0100526)2.01378477
111Hypothermia (HP:0002045)15.6140587
112Orthostatic hypotension (HP:0001278)10.4066302
113Emotional lability (HP:0000712)1.99090382
114Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98684652
115Renal Fanconi syndrome (HP:0001994)1.96548437
116Anhidrosis (HP:0000970)1.95791819
117Hypoglycemic coma (HP:0001325)1.95545079
118Hyporeflexia of lower limbs (HP:0002600)1.93053767
119Congenital sensorineural hearing impairment (HP:0008527)1.93005594
120Muscle stiffness (HP:0003552)1.92264559
121Abnormality of dental color (HP:0011073)1.90970578
122Abnormality of the pancreatic islet cells (HP:0006476)1.90787900
123Abnormality of endocrine pancreas physiology (HP:0012093)1.90787900
124Ketosis (HP:0001946)1.88754534
125Increased corneal curvature (HP:0100692)1.87108448
126Keratoconus (HP:0000563)1.87108448
127Severe muscular hypotonia (HP:0006829)1.86460818
128Cerebral edema (HP:0002181)1.85765627
129Hypoglycemic seizures (HP:0002173)1.85477301
130Fat malabsorption (HP:0002630)1.85309518
131Abolished electroretinogram (ERG) (HP:0000550)1.85279893
132Craniofacial dystonia (HP:0012179)1.84475499
133Metaphyseal dysplasia (HP:0100255)1.82740774
134Tubulointerstitial nephritis (HP:0001970)1.82596503
135Increased hepatocellular lipid droplets (HP:0006565)1.81550639
136Palpitations (HP:0001962)1.80407681
137Exercise-induced myalgia (HP:0003738)1.79780847
138Epileptic encephalopathy (HP:0200134)1.79717642
139Prominent metopic ridge (HP:0005487)1.79092479
140Progressive cerebellar ataxia (HP:0002073)1.78055487
141Stage 5 chronic kidney disease (HP:0003774)1.77331800
142Bradycardia (HP:0001662)1.76255266
143Torticollis (HP:0000473)1.75548939
144Pancreatic islet-cell hyperplasia (HP:0004510)1.75206081
145Wrist flexion contracture (HP:0001239)1.74923575
146Goiter (HP:0000853)1.74837092
147Menstrual irregularities (HP:0000858)1.74485571
148Oligomenorrhea (HP:0000876)1.73721135
149Focal dystonia (HP:0004373)1.72451439
150Lipid accumulation in hepatocytes (HP:0006561)1.71902797
151Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.70068244
152Exercise-induced muscle cramps (HP:0003710)1.69221871
153Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68190110
154Abnormality of the corticospinal tract (HP:0002492)1.66837790
155Hypokinesia (HP:0002375)1.65724652
156Abnormal ciliary motility (HP:0012262)1.64693836
157Neuroblastoma (HP:0003006)1.64142150
158Primitive neuroectodermal tumor (HP:0030065)1.64142150
159Neuroblastic tumors (HP:0004376)1.64142150
160Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.64142150
161Insidious onset (HP:0003587)1.62759987
162Termporal pattern (HP:0011008)1.62759987
163Hypoplasia of the brainstem (HP:0002365)1.61225023
164Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61225023
165Hypotrichosis (HP:0001006)1.60932435
166Ankle clonus (HP:0011448)1.58314368
167Increased CSF lactate (HP:0002490)1.58211161
168Absence seizures (HP:0002121)1.57476295
169Rapidly progressive (HP:0003678)1.56874663
170Increased serum pyruvate (HP:0003542)1.53895823
171Abnormality of glycolysis (HP:0004366)1.53895823
172Asymmetric septal hypertrophy (HP:0001670)1.53823291
173Retinal atrophy (HP:0001105)1.52269889
174Febrile seizures (HP:0002373)1.52018359
175Growth hormone excess (HP:0000845)1.50429631
176Supranuclear gaze palsy (HP:0000605)1.50151438
177Neoplasm of the thyroid gland (HP:0100031)1.48555549
178Self-mutilation (HP:0000742)1.48017027
179Hepatic necrosis (HP:0002605)1.47731859
180Hepatocellular necrosis (HP:0001404)1.46497067
181Hypercortisolism (HP:0001578)1.45881683
182Difficulty running (HP:0009046)1.44270496
183Aplasia/Hypoplasia of the macula (HP:0008059)1.43675534
184Optic disc pallor (HP:0000543)1.43504033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK17.97258145
2GRK76.44844145
3FRK4.68537932
4MATK4.44163034
5GRK53.44955154
6NLK2.47230427
7MAP4K22.35125752
8STK38L2.35078852
9MAP3K42.30299314
10BMPR1B2.21251207
11BCKDK2.16279154
12PNCK2.11780810
13ADRBK22.11335678
14MAPKAPK52.09237024
15BUB11.98179012
16ADRBK11.96976516
17NTRK31.92632509
18MAP2K11.92131503
19OXSR11.87632053
20NUAK11.84585773
21CSNK1G31.80924217
22MAP2K71.75291327
23TNIK1.73732439
24PIK3CA1.69259983
25GRK11.59695860
26ARAF1.58688498
27CSNK1G21.55058490
28TAOK31.52810469
29NME21.51160020
30PRKG21.49951747
31BRSK21.48743767
32NTRK21.47616946
33DAPK21.46471948
34FER1.41492264
35EPHA31.36684954
36PHKG21.30961435
37PHKG11.30961435
38STK381.30072382
39MUSK1.28786870
40PIK3CG1.28632255
41ERBB31.27921680
42FGFR21.24987933
43CSNK1G11.23664011
44GRK61.22690114
45MAP2K41.21751562
46NME11.20944655
47MINK11.20181243
48MAP3K21.13245757
49TGFBR21.12012977
50SGK21.11536989
51UHMK11.11131841
52MARK11.10258527
53PRKCE1.06752476
54TRIM281.05966400
55LATS21.05120072
56LIMK11.04461300
57PRKCQ1.03645878
58TSSK61.03144231
59MAP3K70.99757203
60PASK0.98879987
61MAP3K120.98229205
62STK160.98066912
63VRK20.95398679
64ERBB20.93343943
65KSR20.92511494
66MAPK40.92454784
67WNK10.92386646
68STK30.92382384
69LMTK20.89465836
70MAP3K90.87300681
71WNK30.85848559
72TESK10.84523507
73INSRR0.84436796
74CASK0.84214549
75PINK10.83800769
76ILK0.77428248
77WNK40.74009830
78HIPK20.73430548
79MKNK20.72484865
80PRKAA20.72288338
81CAMKK20.71781303
82RPS6KB20.71690729
83SGK30.71100604
84RPS6KA20.69646761
85SGK4940.69354389
86SGK2230.69354389
87TRPM70.67980197
88AKT30.67971065
89PTK2B0.66623152
90MAPK130.65726540
91STK240.65387267
92PRKAA10.64149327
93MAP2K60.61921665
94STK390.61722884
95PRKCG0.60674016
96MAPKAPK30.60393518
97DYRK20.60206312
98CDK50.60105332
99BMPR20.59797428
100FGR0.59415103
101DAPK10.59153448
102PDK30.58453118
103PDK40.58453118
104SIK10.58165381
105ACVR1B0.58147490
106LATS10.57584891
107CAMK2B0.57434437
108IRAK10.57039342
109MYLK0.56757507
110CDK150.55947318
111CDK180.55171240
112CAMK2G0.54417862
113ROCK10.54093292
114MAP2K20.53181417
115CDK140.50795796
116CDK11A0.50341535
117ERBB40.49841342
118PLK40.49657259
119SIK30.48790109
120IGF1R0.48081137
121PRKD20.46835829
122MAPK120.46394150
123FLT30.46243755
124MAPK150.44041057
125OBSCN0.43653957
126RPS6KA50.42852449
127PRKD10.42820767
128MST40.42112172
129DAPK30.41070517
130CAMK10.41068399
131EEF2K0.41045506
132PRKACA0.40483468
133CAMK2D0.40014767
134PIM20.39849049
135CSNK1E0.39817741
136MET0.39380065
137CAMK2A0.39001422
138PRKG10.37947673
139PRKCA0.37655034
140IKBKB0.37400812
141CAMKK10.36935844
142PLK20.36750900
143TGFBR10.36141427
144RET0.34986749
145PRKACG0.33494886
146PDGFRA0.32686210
147TIE10.31885777
148SRC0.31853750
149CSNK1A10.30270234
150LRRK20.29664809
151PAK30.29045246
152STK110.28790700
153MAPK80.28706386
154DYRK30.27573949
155PRKCB0.26563593
156SIK20.26180575
157CSNK1D0.25428842
158TTN0.23846820
159PDK20.23371969
160PRKCZ0.22476076
161CHUK0.21613085
162DYRK1A0.21472799
163FGFR10.20541891

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003505.23225347
2Phenylalanine metabolism_Homo sapiens_hsa003604.65222177
3Maturity onset diabetes of the young_Homo sapiens_hsa049504.08347599
4Histidine metabolism_Homo sapiens_hsa003403.20346468
5Oxidative phosphorylation_Homo sapiens_hsa001902.84863087
6Cocaine addiction_Homo sapiens_hsa050302.81998137
7Parkinsons disease_Homo sapiens_hsa050122.71371094
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.64926104
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.29550042
10Cholinergic synapse_Homo sapiens_hsa047252.28510121
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.23005098
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22968825
13Tryptophan metabolism_Homo sapiens_hsa003802.10993954
14Amphetamine addiction_Homo sapiens_hsa050312.09131188
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08831626
16Alzheimers disease_Homo sapiens_hsa050102.03331555
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95406057
18Synaptic vesicle cycle_Homo sapiens_hsa047211.92674240
19Serotonergic synapse_Homo sapiens_hsa047261.90502465
20Collecting duct acid secretion_Homo sapiens_hsa049661.89985313
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86537449
22Dopaminergic synapse_Homo sapiens_hsa047281.86175658
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.84267587
24Proteasome_Homo sapiens_hsa030501.80620218
25Phototransduction_Homo sapiens_hsa047441.80077022
26Retinol metabolism_Homo sapiens_hsa008301.72520901
27Circadian rhythm_Homo sapiens_hsa047101.72510261
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71827822
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66797133
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65167867
31ABC transporters_Homo sapiens_hsa020101.60111944
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.59942243
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59804062
34Huntingtons disease_Homo sapiens_hsa050161.53843117
35Chemical carcinogenesis_Homo sapiens_hsa052041.50470706
36Renin secretion_Homo sapiens_hsa049241.48649788
37Arginine and proline metabolism_Homo sapiens_hsa003301.45847155
38RNA polymerase_Homo sapiens_hsa030201.43863556
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43017824
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39686346
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.38918236
42Propanoate metabolism_Homo sapiens_hsa006401.36460892
43Selenocompound metabolism_Homo sapiens_hsa004501.30827771
44Caffeine metabolism_Homo sapiens_hsa002321.28425511
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27677999
46* Bile secretion_Homo sapiens_hsa049761.27211749
47Complement and coagulation cascades_Homo sapiens_hsa046101.25745250
48Peroxisome_Homo sapiens_hsa041461.24841569
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21792503
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18629575
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15655418
52Gastric acid secretion_Homo sapiens_hsa049711.14721489
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13966272
54Long-term depression_Homo sapiens_hsa047301.13874546
55African trypanosomiasis_Homo sapiens_hsa051431.13250232
56Insulin secretion_Homo sapiens_hsa049111.12498675
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11225124
58Sulfur metabolism_Homo sapiens_hsa009201.10779772
59Gap junction_Homo sapiens_hsa045401.09350622
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08702575
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08141350
62Starch and sucrose metabolism_Homo sapiens_hsa005001.08085458
63Butanoate metabolism_Homo sapiens_hsa006501.04351431
64Circadian entrainment_Homo sapiens_hsa047131.04178207
65Vitamin digestion and absorption_Homo sapiens_hsa049771.02942198
66Salivary secretion_Homo sapiens_hsa049701.01739759
67Glycerolipid metabolism_Homo sapiens_hsa005611.00186090
68GnRH signaling pathway_Homo sapiens_hsa049121.00107486
69Basal transcription factors_Homo sapiens_hsa030220.99176011
70Olfactory transduction_Homo sapiens_hsa047400.97393304
71Protein digestion and absorption_Homo sapiens_hsa049740.97009922
72Fatty acid elongation_Homo sapiens_hsa000620.96212484
73Protein export_Homo sapiens_hsa030600.95438893
74Steroid biosynthesis_Homo sapiens_hsa001000.95091401
75Pyruvate metabolism_Homo sapiens_hsa006200.94954535
76Cardiac muscle contraction_Homo sapiens_hsa042600.93887178
77Nitrogen metabolism_Homo sapiens_hsa009100.93599538
78Vibrio cholerae infection_Homo sapiens_hsa051100.92003367
79Fatty acid metabolism_Homo sapiens_hsa012120.87379455
80Sphingolipid metabolism_Homo sapiens_hsa006000.86998357
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86965126
82Glutamatergic synapse_Homo sapiens_hsa047240.86750773
83* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84708677
84Regulation of autophagy_Homo sapiens_hsa041400.83419564
85Arachidonic acid metabolism_Homo sapiens_hsa005900.83176578
86Glutathione metabolism_Homo sapiens_hsa004800.78996737
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78912255
88Renin-angiotensin system_Homo sapiens_hsa046140.78069969
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77806647
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76378236
91* Pancreatic secretion_Homo sapiens_hsa049720.75779608
92Estrogen signaling pathway_Homo sapiens_hsa049150.74243706
93Tight junction_Homo sapiens_hsa045300.73401248
94Fatty acid degradation_Homo sapiens_hsa000710.72799636
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70712318
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70150352
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.68658222
98Linoleic acid metabolism_Homo sapiens_hsa005910.68552224
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.68136584
100Folate biosynthesis_Homo sapiens_hsa007900.68077055
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.67688507
102Taste transduction_Homo sapiens_hsa047420.67629934
103Alcoholism_Homo sapiens_hsa050340.67034297
104beta-Alanine metabolism_Homo sapiens_hsa004100.66553208
105Thyroid hormone synthesis_Homo sapiens_hsa049180.64260343
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63199521
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62340090
108Long-term potentiation_Homo sapiens_hsa047200.60836552
109PPAR signaling pathway_Homo sapiens_hsa033200.60304962
110Glucagon signaling pathway_Homo sapiens_hsa049220.60072183
111Dorso-ventral axis formation_Homo sapiens_hsa043200.59950288
112Hepatitis C_Homo sapiens_hsa051600.56263816
113Thyroid cancer_Homo sapiens_hsa052160.55130772
114Calcium signaling pathway_Homo sapiens_hsa040200.55037569
115One carbon pool by folate_Homo sapiens_hsa006700.53272194
116Oxytocin signaling pathway_Homo sapiens_hsa049210.52979619
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51524099
118Ovarian steroidogenesis_Homo sapiens_hsa049130.51007015
119Fructose and mannose metabolism_Homo sapiens_hsa000510.50374415
120RNA degradation_Homo sapiens_hsa030180.47814248
121Ether lipid metabolism_Homo sapiens_hsa005650.47647098
122Carbon metabolism_Homo sapiens_hsa012000.47275676
123Arginine biosynthesis_Homo sapiens_hsa002200.46934360
124Ribosome_Homo sapiens_hsa030100.46696863
125GABAergic synapse_Homo sapiens_hsa047270.45252033
126cAMP signaling pathway_Homo sapiens_hsa040240.44117125
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.42639730
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42577149
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.42059068
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41847594
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40731696
132Fat digestion and absorption_Homo sapiens_hsa049750.40386284
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.39881080
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39838144
135Melanogenesis_Homo sapiens_hsa049160.39688453
136Prion diseases_Homo sapiens_hsa050200.39665374
137Lysosome_Homo sapiens_hsa041420.37284108
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37216019
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37188345
140Phagosome_Homo sapiens_hsa041450.36301472
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36060523
142TGF-beta signaling pathway_Homo sapiens_hsa043500.35619554
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34184575
144Sulfur relay system_Homo sapiens_hsa041220.33811499
145Metabolic pathways_Homo sapiens_hsa011000.33686973
146Purine metabolism_Homo sapiens_hsa002300.32770455
147Fatty acid biosynthesis_Homo sapiens_hsa000610.32643465
148Pyrimidine metabolism_Homo sapiens_hsa002400.31308382
149Rheumatoid arthritis_Homo sapiens_hsa053230.30582851
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30288146
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.30234587
152Mineral absorption_Homo sapiens_hsa049780.29840054
153Type II diabetes mellitus_Homo sapiens_hsa049300.29410339
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.28203270
155Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26979428
156Insulin signaling pathway_Homo sapiens_hsa049100.26023749
157Pentose phosphate pathway_Homo sapiens_hsa000300.25935176
158Morphine addiction_Homo sapiens_hsa050320.25812294

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