SCUBE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)9.04549347
2lateral sprouting from an epithelium (GO:0060601)8.01029209
3prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060527.53825399
4mesenchymal-epithelial cell signaling (GO:0060638)7.02380887
5cell proliferation in forebrain (GO:0021846)6.12217631
6bone trabecula formation (GO:0060346)5.94337736
7behavioral response to nicotine (GO:0035095)5.70783538
8cell proliferation involved in metanephros development (GO:0072203)5.66476484
9regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.46457941
10negative regulation of osteoblast proliferation (GO:0033689)5.46021045
11cell proliferation involved in kidney development (GO:0072111)5.27931055
12planar cell polarity pathway involved in neural tube closure (GO:0090179)5.25688512
13branching involved in prostate gland morphogenesis (GO:0060442)5.23436132
14regulation of non-canonical Wnt signaling pathway (GO:2000050)5.15354166
15sulfation (GO:0051923)5.13223862
16craniofacial suture morphogenesis (GO:0097094)5.02238983
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.92045150
18regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.84714554
19radial glial cell differentiation (GO:0060019)4.83737130
20mesenchymal cell proliferation (GO:0010463)4.75506452
21somite development (GO:0061053)4.72261812
22branching involved in labyrinthine layer morphogenesis (GO:0060670)4.49045419
23branching involved in salivary gland morphogenesis (GO:0060445)4.47371257
24limb bud formation (GO:0060174)4.43003106
25keratinocyte proliferation (GO:0043616)4.41142101
26convergent extension (GO:0060026)4.34578078
27neuronal ion channel clustering (GO:0045161)4.33793873
28prostate gland epithelium morphogenesis (GO:0060740)4.17718835
29cellular response to vitamin D (GO:0071305)4.17234872
30negative regulation of fibroblast apoptotic process (GO:2000270)4.16065586
31cellular response to prostaglandin stimulus (GO:0071379)4.13884064
32neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.08122456
33dorsal/ventral axis specification (GO:0009950)3.97056321
34pyrimidine nucleobase catabolic process (GO:0006208)3.96998655
35negative regulation of catenin import into nucleus (GO:0035414)3.96553063
36negative regulation of JUN kinase activity (GO:0043508)3.93053217
37renal system development (GO:0072001)3.90745753
38presynaptic membrane assembly (GO:0097105)3.86545687
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.83381266
40water-soluble vitamin biosynthetic process (GO:0042364)3.69231949
41cranial suture morphogenesis (GO:0060363)3.68596592
42central nervous system projection neuron axonogenesis (GO:0021952)3.68318649
43artery smooth muscle contraction (GO:0014824)3.67555947
44protein polyglutamylation (GO:0018095)3.65559081
45cellular response to cholesterol (GO:0071397)3.65162751
46regulation of glomerulus development (GO:0090192)3.61972474
47postsynaptic membrane organization (GO:0001941)3.61237146
48otic vesicle formation (GO:0030916)3.60136300
49digestive tract morphogenesis (GO:0048546)3.59916543
50branch elongation of an epithelium (GO:0060602)3.59442752
51positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.58372445
52presynaptic membrane organization (GO:0097090)3.56397944
53negative regulation of axon guidance (GO:1902668)3.56014795
54negative regulation of gluconeogenesis (GO:0045721)3.54595225
55sequestering of extracellular ligand from receptor (GO:0035581)3.51739233
56artery development (GO:0060840)3.50661244
57regulation of posttranscriptional gene silencing (GO:0060147)3.48893675
58regulation of gene silencing by miRNA (GO:0060964)3.48893675
59regulation of gene silencing by RNA (GO:0060966)3.48893675
60negative chemotaxis (GO:0050919)3.47317287
61negative regulation of transcription regulatory region DNA binding (GO:2000678)3.45664374
62epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.42151252
63lung epithelium development (GO:0060428)3.41636786
64Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.40109153
65axis elongation (GO:0003401)3.38424703
66hindlimb morphogenesis (GO:0035137)3.37872447
67gamma-aminobutyric acid transport (GO:0015812)3.32152497
68transmission of nerve impulse (GO:0019226)3.32111952
69spinal cord development (GO:0021510)3.29308660
70regulation of establishment of planar polarity (GO:0090175)3.27699253
71tonic smooth muscle contraction (GO:0014820)3.25052263
72negative regulation of smoothened signaling pathway (GO:0045879)3.24763813
73regulation of collateral sprouting (GO:0048670)3.24032922
74positive regulation of cardiac muscle cell differentiation (GO:2000727)3.22971158
75regulation of smoothened signaling pathway (GO:0008589)3.22476368
76retinal ganglion cell axon guidance (GO:0031290)3.19862974
77negative regulation of axon extension involved in axon guidance (GO:0048843)3.19752247
78cellular response to ATP (GO:0071318)3.17136572
79negative regulation of systemic arterial blood pressure (GO:0003085)3.15453494
80kynurenine metabolic process (GO:0070189)3.14855263
81regulation of keratinocyte proliferation (GO:0010837)3.14775905
82response to prostaglandin E (GO:0034695)3.14377642
83organ growth (GO:0035265)3.13379826
84regulation of short-term neuronal synaptic plasticity (GO:0048172)3.12197841
85pituitary gland development (GO:0021983)3.10967104
86mesenchymal cell differentiation (GO:0048762)3.09655173
87dentate gyrus development (GO:0021542)3.08838213
88hair follicle morphogenesis (GO:0031069)3.08326970
89glial cell migration (GO:0008347)3.03779823
90hematopoietic stem cell differentiation (GO:0060218)3.03742943
91lung-associated mesenchyme development (GO:0060484)3.03132254
92cell differentiation involved in kidney development (GO:0061005)3.02592852
93regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.01762358
94NLS-bearing protein import into nucleus (GO:0006607)3.01497783
95limb development (GO:0060173)3.00573814
96appendage development (GO:0048736)3.00573814
97nucleobase catabolic process (GO:0046113)2.99967400
98positive regulation of cAMP-mediated signaling (GO:0043950)2.98707097
993-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.95490915
100purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.95490915
101regulation of DNA endoreduplication (GO:0032875)2.94700229
102regulation of developmental pigmentation (GO:0048070)2.94381325
103tryptophan catabolic process (GO:0006569)2.93622011
104indole-containing compound catabolic process (GO:0042436)2.93622011
105indolalkylamine catabolic process (GO:0046218)2.93622011
106regulation of morphogenesis of a branching structure (GO:0060688)2.92387525
107indolalkylamine metabolic process (GO:0006586)2.91533113
108spinal cord motor neuron differentiation (GO:0021522)2.91355468
109synaptic vesicle docking involved in exocytosis (GO:0016081)2.91222517
110embryonic hindlimb morphogenesis (GO:0035116)2.91051193
111proximal/distal pattern formation (GO:0009954)2.90793342
112organ formation (GO:0048645)2.90653713
113regulation of cell proliferation involved in kidney development (GO:1901722)2.90255432
114positive regulation of gastrulation (GO:2000543)2.89471800
115locomotory exploration behavior (GO:0035641)2.88512698
116negative regulation of multicellular organism growth (GO:0040015)2.86931669
117resolution of meiotic recombination intermediates (GO:0000712)2.86094591
118axon extension involved in axon guidance (GO:0048846)2.85745645
119neuron projection extension involved in neuron projection guidance (GO:1902284)2.85745645
120secondary heart field specification (GO:0003139)2.84480967
121heart field specification (GO:0003128)2.84480967
122protein localization to cell surface (GO:0034394)2.84298775
123regulation of pigment cell differentiation (GO:0050932)2.84074259
124synaptic vesicle maturation (GO:0016188)2.83809021
125regulation of systemic arterial blood pressure by hormone (GO:0001990)2.83273417
126regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.83273417
127endocrine process (GO:0050886)2.83273417
128cellular response to sterol (GO:0036315)2.82941002
129regulation of mesoderm development (GO:2000380)2.82634886
130protein targeting to plasma membrane (GO:0072661)2.82570771
131regulation of osteoblast proliferation (GO:0033688)2.81930628
132vocalization behavior (GO:0071625)2.81612639
133tryptophan metabolic process (GO:0006568)2.80727825
134tongue development (GO:0043586)2.80006552
135central nervous system neuron axonogenesis (GO:0021955)2.79924103
136layer formation in cerebral cortex (GO:0021819)2.78363042
137dendritic spine morphogenesis (GO:0060997)2.77229141
138protein localization to synapse (GO:0035418)2.75937269
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75680774
140mitochondrial respiratory chain complex I assembly (GO:0032981)2.75680774
141NADH dehydrogenase complex assembly (GO:0010257)2.75680774
142cellular response to vitamin (GO:0071295)2.75381632
143thalamus development (GO:0021794)2.75308713
144non-canonical Wnt signaling pathway (GO:0035567)2.73282574
145glutamate secretion (GO:0014047)2.72773394
146mesonephros development (GO:0001823)2.71705786
147positive regulation of fat cell differentiation (GO:0045600)2.71429750
148positive regulation of smoothened signaling pathway (GO:0045880)2.71107489
149cartilage morphogenesis (GO:0060536)2.70804410
150negative regulation of response to food (GO:0032096)2.70541647
151negative regulation of appetite (GO:0032099)2.70541647
152negative regulation of telomere maintenance (GO:0032205)2.70149529
153kidney morphogenesis (GO:0060993)2.67767624
154vascular smooth muscle contraction (GO:0014829)2.67472653
155organ induction (GO:0001759)2.66720845
156negative regulation of osteoblast differentiation (GO:0045668)2.65451502
157dorsal/ventral pattern formation (GO:0009953)2.65109346
158positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.65037811
159positive regulation of fatty acid beta-oxidation (GO:0032000)2.64793196
160pharyngeal system development (GO:0060037)2.64493167
161response to follicle-stimulating hormone (GO:0032354)2.63448617
162negative regulation of astrocyte differentiation (GO:0048712)2.63211679
163olfactory bulb development (GO:0021772)2.60860475
164outer ear morphogenesis (GO:0042473)2.59064583
165negative regulation of DNA binding (GO:0043392)2.58197960
166fucose catabolic process (GO:0019317)2.58089763
167L-fucose metabolic process (GO:0042354)2.58089763
168L-fucose catabolic process (GO:0042355)2.58089763
169protein complex biogenesis (GO:0070271)2.55691527
170head development (GO:0060322)2.55617309
171neuron fate determination (GO:0048664)2.54682288
172epithelial cilium movement (GO:0003351)2.54566934
173regulation of phospholipid biosynthetic process (GO:0071071)2.51368112
174neural precursor cell proliferation (GO:0061351)2.51282856
175response to pheromone (GO:0019236)2.50999675
176dopaminergic neuron differentiation (GO:0071542)2.48978924
177epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45314735
178positive regulation of fatty acid oxidation (GO:0046321)2.42996638
179regulation of hippo signaling (GO:0035330)2.42561258
180G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41142015
181hindbrain development (GO:0030902)2.40917218
182nonmotile primary cilium assembly (GO:0035058)2.40482390
183detection of light stimulus involved in sensory perception (GO:0050962)2.39882335
184detection of light stimulus involved in visual perception (GO:0050908)2.39882335
185fear response (GO:0042596)2.38686858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67539030
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.37922071
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.15008453
4GBX2_23144817_ChIP-Seq_PC3_Human2.98355405
5* EED_16625203_ChIP-ChIP_MESCs_Mouse2.88568339
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87064726
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86084447
8* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.75044107
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74719270
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.74268848
11ZNF274_21170338_ChIP-Seq_K562_Hela2.66878897
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66080701
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66080701
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53186170
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48271591
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41070054
17AR_21572438_ChIP-Seq_LNCaP_Human2.34330015
18IGF1R_20145208_ChIP-Seq_DFB_Human2.33280775
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23648740
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.19393891
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17158232
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.15370645
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10687704
24EWS_26573619_Chip-Seq_HEK293_Human2.09418281
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07005265
26* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.02464830
27VDR_22108803_ChIP-Seq_LS180_Human1.97471859
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91579730
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89579322
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89326773
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83622076
32RNF2_27304074_Chip-Seq_NSC_Mouse1.83307603
33IRF1_19129219_ChIP-ChIP_H3396_Human1.80606582
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78992714
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.75947536
36DROSHA_22980978_ChIP-Seq_HELA_Human1.74161575
37* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70858916
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70743111
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70716970
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70012463
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68488154
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68368828
43SMAD4_21799915_ChIP-Seq_A2780_Human1.66420513
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64030999
45P300_19829295_ChIP-Seq_ESCs_Human1.64015403
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.58868499
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57592868
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.55736160
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50545982
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48496757
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48442691
52AHR_22903824_ChIP-Seq_MCF-7_Human1.47097338
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.46913175
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.46170210
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45527694
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45432052
57CBP_20019798_ChIP-Seq_JUKART_Human1.43941046
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43941046
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43266420
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42000358
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41484036
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40226867
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40154516
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39298925
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38933926
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38497933
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38497933
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37836590
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37437731
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.36198551
71TBX3_20139965_ChIP-Seq_ESCs_Mouse1.36056722
72ER_23166858_ChIP-Seq_MCF-7_Human1.36027442
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.35342103
74TBX3_20139965_ChIP-Seq_MESCs_Mouse1.35147870
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.34544574
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.33359667
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.32325292
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31906577
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.27498493
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27389955
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26960602
82TAF15_26573619_Chip-Seq_HEK293_Human1.26358426
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26004552
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25961171
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25907828
86REST_21632747_ChIP-Seq_MESCs_Mouse1.24887329
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24857702
88STAT3_23295773_ChIP-Seq_U87_Human1.24267349
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.24254855
90MYC_18940864_ChIP-ChIP_HL60_Human1.23732622
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23562217
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23099681
93FUS_26573619_Chip-Seq_HEK293_Human1.22994538
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22569068
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22355887
96RARB_27405468_Chip-Seq_BRAIN_Mouse1.22083716
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19807397
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19343661
99TP53_18474530_ChIP-ChIP_U2OS_Human1.18368031
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17585141
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15005772
102AR_19668381_ChIP-Seq_PC3_Human1.14550360
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14488722
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.13490617
105RXR_22108803_ChIP-Seq_LS180_Human1.12879750
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11690194
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11360284
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09911890
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08982657
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07867486
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07806944
112NANOG_16153702_ChIP-ChIP_HESCs_Human1.07468335
113TP53_16413492_ChIP-PET_HCT116_Human1.06782828
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06286143
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06080551
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05170941
117AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04239103
118RUNX2_22187159_ChIP-Seq_PCA_Human1.03501784
119BP1_19119308_ChIP-ChIP_Hs578T_Human1.01835789
120KDM2B_26808549_Chip-Seq_REH_Human1.00232533
121TRIM28_21343339_ChIP-Seq_HEK293_Human1.00117135
122* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99556801
123SALL1_21062744_ChIP-ChIP_HESCs_Human0.99344880
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.99256883
125BCAT_22108803_ChIP-Seq_LS180_Human0.98555353
126* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98091510
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.96902244
128* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96717117
129TCF4_23295773_ChIP-Seq_U87_Human0.96657250
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.96632060
131KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96628640
132* REST_18959480_ChIP-ChIP_MESCs_Mouse0.96244312
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95740384
134TP53_22573176_ChIP-Seq_HFKS_Human0.95589690
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95167345
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94870537
137AR_25329375_ChIP-Seq_VCAP_Human0.94291351
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.94234691
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.93926305
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93196229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005187_abnormal_penis_morphology5.00993110
2MP0006292_abnormal_olfactory_placode4.66676469
3MP0002938_white_spotting3.82839542
4MP0005503_abnormal_tendon_morphology3.50734005
5MP0000566_synostosis3.20780402
6MP0001299_abnormal_eye_distance/3.01270991
7MP0005248_abnormal_Harderian_gland2.70063578
8MP0004859_abnormal_synaptic_plasticity2.69910075
9MP0004272_abnormal_basement_membrane2.66978338
10MP0009250_abnormal_appendicular_skeleto2.42361743
11MP0001661_extended_life_span2.38182390
12MP0002102_abnormal_ear_morphology2.36353637
13MP0000537_abnormal_urethra_morphology2.35446718
14MP0003011_delayed_dark_adaptation2.29776546
15MP0010030_abnormal_orbit_morphology2.26722767
16MP0002653_abnormal_ependyma_morphology2.16778523
17MP0002282_abnormal_trachea_morphology2.14400379
18MP0000428_abnormal_craniofacial_morphol2.14351584
19MP0001485_abnormal_pinna_reflex2.06784710
20MP0001293_anophthalmia2.02599734
21MP0004134_abnormal_chest_morphology1.96727501
22MP0003880_abnormal_central_pattern1.91513453
23MP0003635_abnormal_synaptic_transmissio1.87944353
24MP0001529_abnormal_vocalization1.83879258
25MP0000569_abnormal_digit_pigmentation1.83735874
26MP0006276_abnormal_autonomic_nervous1.80727984
27MP0008789_abnormal_olfactory_epithelium1.79196196
28MP0003942_abnormal_urinary_system1.78849282
29MP0003385_abnormal_body_wall1.76722531
30MP0000778_abnormal_nervous_system1.75270172
31MP0000579_abnormal_nail_morphology1.73792877
32MP0000751_myopathy1.73275839
33MP0009780_abnormal_chondrocyte_physiolo1.72527886
34MP0003938_abnormal_ear_development1.66422081
35MP0002108_abnormal_muscle_morphology1.66078845
36MP0005646_abnormal_pituitary_gland1.61611015
37MP0000647_abnormal_sebaceous_gland1.58994498
38MP0003283_abnormal_digestive_organ1.58452820
39MP0000462_abnormal_digestive_system1.57207246
40MP0003122_maternal_imprinting1.56243672
41MP0009053_abnormal_anal_canal1.55078372
42MP0002160_abnormal_reproductive_system1.53005642
43MP0000026_abnormal_inner_ear1.52532314
44MP0009379_abnormal_foot_pigmentation1.52219117
45MP0005551_abnormal_eye_electrophysiolog1.51849837
46MP0002063_abnormal_learning/memory/cond1.48400277
47MP0004270_analgesia1.48248347
48MP0006072_abnormal_retinal_apoptosis1.42800125
49* MP0002116_abnormal_craniofacial_bone1.40601980
50MP0002572_abnormal_emotion/affect_behav1.37373268
51MP0002089_abnormal_postnatal_growth/wei1.37351288
52MP0005499_abnormal_olfactory_system1.37011786
53MP0005394_taste/olfaction_phenotype1.37011786
54MP0005257_abnormal_intraocular_pressure1.36306312
55MP0003195_calcinosis1.35532670
56MP0005367_renal/urinary_system_phenotyp1.33426834
57MP0000516_abnormal_urinary_system1.33426834
58MP0005377_hearing/vestibular/ear_phenot1.29621840
59MP0003878_abnormal_ear_physiology1.29621840
60MP0000427_abnormal_hair_cycle1.28541957
61MP0002557_abnormal_social/conspecific_i1.28165788
62MP0003890_abnormal_embryonic-extraembry1.27126204
63MP0003935_abnormal_craniofacial_develop1.25604590
64MP0005253_abnormal_eye_physiology1.24094812
65MP0004142_abnormal_muscle_tone1.22013824
66MP0003937_abnormal_limbs/digits/tail_de1.20932847
67MP0003755_abnormal_palate_morphology1.20782064
68MP0008775_abnormal_heart_ventricle1.20054266
69MP0002234_abnormal_pharynx_morphology1.19722787
70MP0004145_abnormal_muscle_electrophysio1.18150839
71MP0002064_seizures1.18140179
72MP0005075_abnormal_melanosome_morpholog1.17900959
73MP0002109_abnormal_limb_morphology1.17790725
74MP0002932_abnormal_joint_morphology1.17729810
75MP0002736_abnormal_nociception_after1.16461890
76MP0005508_abnormal_skeleton_morphology1.15724889
77MP0009046_muscle_twitch1.15662420
78MP0001177_atelectasis1.15492436
79MP0005195_abnormal_posterior_eye1.14847826
80MP0000955_abnormal_spinal_cord1.14345395
81MP0000534_abnormal_ureter_morphology1.13896518
82MP0001286_abnormal_eye_development1.13153528
83MP0009745_abnormal_behavioral_response1.12944066
84* MP0002752_abnormal_somatic_nervous1.12553359
85MP0000762_abnormal_tongue_morphology1.12148177
86MP0008877_abnormal_DNA_methylation1.11406200
87MP0001486_abnormal_startle_reflex1.10904005
88MP0005389_reproductive_system_phenotype1.10009253
89MP0003567_abnormal_fetal_cardiomyocyte1.09979500
90MP0005171_absent_coat_pigmentation1.09569633
91MP0001963_abnormal_hearing_physiology1.09171610
92MP0008872_abnormal_physiological_respon1.08545221
93MP0003646_muscle_fatigue1.08092460
94MP0002138_abnormal_hepatobiliary_system1.07664453
95MP0002751_abnormal_autonomic_nervous1.07544204
96MP0001984_abnormal_olfaction1.07472438
97MP0003119_abnormal_digestive_system1.07124057
98MP0002735_abnormal_chemical_nociception1.06808595
99MP0002638_abnormal_pupillary_reflex1.05640700
100MP0000049_abnormal_middle_ear1.04960089
101MP0002177_abnormal_outer_ear1.02461211
102MP0004742_abnormal_vestibular_system1.02243433
103MP0002184_abnormal_innervation1.02156469
104MP0001970_abnormal_pain_threshold1.01448062
105MP0000163_abnormal_cartilage_morphology1.01439061
106MP0002876_abnormal_thyroid_physiology1.00311614
107MP0000639_abnormal_adrenal_gland0.98750387
108MP0002295_abnormal_pulmonary_circulatio0.98050964
109MP0004133_heterotaxia0.97871460
110MP0002115_abnormal_skeleton_extremities0.96434010
111* MP0003861_abnormal_nervous_system0.95233167
112MP0005084_abnormal_gallbladder_morpholo0.95046943
113MP0000432_abnormal_head_morphology0.94292710
114MP0005391_vision/eye_phenotype0.94044009
115MP0004885_abnormal_endolymph0.93735676
116MP0002896_abnormal_bone_mineralization0.92693222
117MP0002249_abnormal_larynx_morphology0.92550548
118MP0001346_abnormal_lacrimal_gland0.92528151
119MP0003136_yellow_coat_color0.91444219
120MP0010368_abnormal_lymphatic_system0.90851145
121MP0000383_abnormal_hair_follicle0.90694018
122MP0001340_abnormal_eyelid_morphology0.89641481
123MP0000631_abnormal_neuroendocrine_gland0.88209645
124MP0002882_abnormal_neuron_morphology0.86777627
125MP0002163_abnormal_gland_morphology0.86206304
126MP0003787_abnormal_imprinting0.86019327
127MP0001502_abnormal_circadian_rhythm0.85887855
128MP0002272_abnormal_nervous_system0.84214481
129* MP0002152_abnormal_brain_morphology0.84214463
130MP0001542_abnormal_bone_strength0.84134738
131MP0004811_abnormal_neuron_physiology0.83381532
132MP0005409_darkened_coat_color0.83213162
133MP0000371_diluted_coat_color0.82618433
134MP0003115_abnormal_respiratory_system0.81108077
135MP0005386_behavior/neurological_phenoty0.80649536
136MP0004924_abnormal_behavior0.80649536
137MP0003121_genomic_imprinting0.79147155
138MP0001968_abnormal_touch/_nociception0.77380273
139MP0002734_abnormal_mechanical_nocicepti0.77086122
140MP0002114_abnormal_axial_skeleton0.76663897
141MP0002733_abnormal_thermal_nociception0.76499272
142MP0005595_abnormal_vascular_smooth0.75131005
143MP0002233_abnormal_nose_morphology0.74844942
144MP0002092_abnormal_eye_morphology0.74147400
145MP0002113_abnormal_skeleton_development0.73165459

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the parietal bone (HP:0002696)6.71769712
2Midline defect of the nose (HP:0004122)6.41116860
3Short 4th metacarpal (HP:0010044)6.08226758
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)6.08226758
5Trigonocephaly (HP:0000243)5.08124791
6Neoplasm of the heart (HP:0100544)4.62061983
7Abnormality of the diencephalon (HP:0010662)4.48907571
8Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.41058552
9Abnormality of the 4th metacarpal (HP:0010012)4.29969302
10Nasolacrimal duct obstruction (HP:0000579)3.98136698
11True hermaphroditism (HP:0010459)3.97348878
12Pancreatic fibrosis (HP:0100732)3.93409970
13Toxemia of pregnancy (HP:0100603)3.90903847
14Pendular nystagmus (HP:0012043)3.86569358
15Abnormality of the nasal septum (HP:0000419)3.78968531
16Pancreatic cysts (HP:0001737)3.69901073
17Septo-optic dysplasia (HP:0100842)3.65194937
18Anteriorly placed anus (HP:0001545)3.54422610
19Alacrima (HP:0000522)3.52266094
20Abnormal number of incisors (HP:0011064)3.45809978
21Genetic anticipation (HP:0003743)3.39558729
22Abnormality of the distal phalanx of the thumb (HP:0009617)3.36143096
23Abnormality of the lacrimal duct (HP:0011481)3.35292833
24Short phalanx of the thumb (HP:0009660)3.33607273
25Aplasia involving bones of the extremities (HP:0009825)3.32903902
26Aplasia involving bones of the upper limbs (HP:0009823)3.32903902
27Aplasia of the phalanges of the hand (HP:0009802)3.32903902
28Broad face (HP:0000283)3.31693527
29Vitreoretinal degeneration (HP:0000655)3.30949792
30Hypoplastic pelvis (HP:0008839)3.30379732
31Bilateral microphthalmos (HP:0007633)3.20166889
32Abnormality of the nasolacrimal system (HP:0000614)3.18767892
33Abnormality of the labia minora (HP:0012880)3.10070828
34Abnormality of the incisor (HP:0000676)3.05525862
35Large earlobe (HP:0009748)3.05386684
36Shallow orbits (HP:0000586)3.05327064
37Broad metatarsal (HP:0001783)3.03851333
38Progressive cerebellar ataxia (HP:0002073)2.99713440
39Supernumerary ribs (HP:0005815)2.96541026
40Keratoconus (HP:0000563)2.94793075
41Increased corneal curvature (HP:0100692)2.94793075
42Exostoses (HP:0100777)2.94628608
43Decreased lacrimation (HP:0000633)2.92061318
44Abolished electroretinogram (ERG) (HP:0000550)2.91757718
45Depressed nasal tip (HP:0000437)2.91731574
46Concave nail (HP:0001598)2.84696948
47Agitation (HP:0000713)2.78629152
48Abnormality of incisor morphology (HP:0011063)2.74629530
49Nephronophthisis (HP:0000090)2.73953834
50Abnormality of midbrain morphology (HP:0002418)2.73499894
51Molar tooth sign on MRI (HP:0002419)2.73499894
52Abnormality of the vertebral endplates (HP:0005106)2.72055799
53Colon cancer (HP:0003003)2.72027059
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.71786673
55Down-sloping shoulders (HP:0200021)2.71108361
56Partial duplication of the phalanx of hand (HP:0009999)2.68116032
57Neoplasm of the oral cavity (HP:0100649)2.65996745
58Polyphagia (HP:0002591)2.65238045
59Supernumerary bones of the axial skeleton (HP:0009144)2.64656908
60Partial duplication of thumb phalanx (HP:0009944)2.62931745
61Sclerocornea (HP:0000647)2.60519994
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.59578598
63Cystic liver disease (HP:0006706)2.59412532
64Aplasia cutis congenita (HP:0001057)2.58108951
65Methylmalonic acidemia (HP:0002912)2.57077302
66Coronal craniosynostosis (HP:0004440)2.55170103
67Microglossia (HP:0000171)2.51887052
68Medulloblastoma (HP:0002885)2.50698984
69Decreased central vision (HP:0007663)2.50001764
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.47992458
71Focal motor seizures (HP:0011153)2.47196935
72Turricephaly (HP:0000262)2.46705324
73Congenital stationary night blindness (HP:0007642)2.45785020
74Optic nerve hypoplasia (HP:0000609)2.45595749
75Abnormal rod and cone electroretinograms (HP:0008323)2.41013189
76Anophthalmia (HP:0000528)2.39760827
77Hypophosphatemic rickets (HP:0004912)2.39226601
78Broad ribs (HP:0000885)2.37591884
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.36672974
80Anencephaly (HP:0002323)2.36440884
81Aqueductal stenosis (HP:0002410)2.34336674
82Irregular vertebral endplates (HP:0003301)2.33446820
83Flat capital femoral epiphysis (HP:0003370)2.31304247
84Deformed sella turcica (HP:0002681)2.30130916
85Glioma (HP:0009733)2.30008956
86Broad toe (HP:0001837)2.28366100
87Rectal fistula (HP:0100590)2.28025870
88Rectovaginal fistula (HP:0000143)2.28025870
89Hypoplastic ischia (HP:0003175)2.27111697
90Broad hallux (HP:0010055)2.22042849
91Asplenia (HP:0001746)2.17140849
92Aplasia/Hypoplasia of the spleen (HP:0010451)2.16920557
93Postaxial foot polydactyly (HP:0001830)2.16147808
94Abnormality of the proximal phalanges of the hand (HP:0009834)2.14189399
95Aplasia/Hypoplasia of the tibia (HP:0005772)2.14165003
96Confusion (HP:0001289)2.13983698
97White forelock (HP:0002211)2.13911140
98Abnormality of the middle phalanges of the hand (HP:0009833)2.12825294
99Hypoplastic labia majora (HP:0000059)2.12159971
100Abnormality of the renal medulla (HP:0100957)2.12061143
101Intestinal fistula (HP:0100819)2.11416495
102Porencephaly (HP:0002132)2.11254516
1033-Methylglutaconic aciduria (HP:0003535)2.10277121
104Short tibia (HP:0005736)2.10090012
105Male pseudohermaphroditism (HP:0000037)2.09912387
106Severe visual impairment (HP:0001141)2.09228270
107Abnormality of the phalanges of the 5th finger (HP:0004213)2.09092651
108Abnormal hand bone ossification (HP:0010660)2.08964599
109Type II lissencephaly (HP:0007260)2.08181042
110Narrow palate (HP:0000189)2.07645149
111Furrowed tongue (HP:0000221)2.07135994
112Humeroradial synostosis (HP:0003041)2.04983697
113Synostosis involving the elbow (HP:0003938)2.04983697
114Methylmalonic aciduria (HP:0012120)2.03799425
115Bronchomalacia (HP:0002780)2.03176723
116Attenuation of retinal blood vessels (HP:0007843)2.02756772
117Increased number of teeth (HP:0011069)2.02444876
118Recurrent corneal erosions (HP:0000495)2.01416982
119Abnormal ossification of hand bones (HP:0005921)2.01242740
120Mesomelia (HP:0003027)2.00850247
121Preaxial foot polydactyly (HP:0001841)1.97886621
122Papilledema (HP:0001085)1.97601682
123Abnormality of the ischium (HP:0003174)1.97124983
124Short femoral neck (HP:0100864)1.94130371
125Abnormality of the sella turcica (HP:0002679)1.93290050
126Hypoventilation (HP:0002791)1.92998086
127Abnormality of DNA repair (HP:0003254)1.91970114
128Bell-shaped thorax (HP:0001591)1.91529962
129Hepatoblastoma (HP:0002884)1.91351114
130Ectopic kidney (HP:0000086)1.90793447
131Hypoplasia of the maxilla (HP:0000327)1.89768348
132Medial flaring of the eyebrow (HP:0010747)1.88976217
133Esophageal atresia (HP:0002032)1.88851709
134Oligodactyly (HP:0012165)1.88707306
135Abnormality of the antihelix (HP:0009738)1.88601961
136Vaginal fistula (HP:0004320)1.88108708
137Abnormality of the labia majora (HP:0012881)1.87939890
138Synostosis of carpal bones (HP:0005048)1.87095875
139Growth hormone deficiency (HP:0000824)1.87001406
140Abnormality of cochlea (HP:0000375)1.86972491
141Small hand (HP:0200055)1.86918338
142Hypoplastic iliac wings (HP:0002866)1.86671327
143Fibular hypoplasia (HP:0003038)1.86420266
144Mixed hearing impairment (HP:0000410)1.86368732
145Blue irides (HP:0000635)1.85969661
146Postaxial hand polydactyly (HP:0001162)1.85025054
147Carpal bone hypoplasia (HP:0001498)1.84952189
148Conical tooth (HP:0000698)1.84771504
149Prominent supraorbital ridges (HP:0000336)1.84532312
150High anterior hairline (HP:0009890)1.84013571
151Congenital hepatic fibrosis (HP:0002612)1.83940667
152Heterochromia iridis (HP:0001100)1.83560232
153Telecanthus (HP:0000506)1.83255348
154Bony spicule pigmentary retinopathy (HP:0007737)1.82956703
155Milia (HP:0001056)1.82706731
156Aplasia/Hypoplasia of the patella (HP:0006498)1.82616943
157Broad thumb (HP:0011304)1.81515474
158Chronic hepatic failure (HP:0100626)1.81142359
159Preaxial hand polydactyly (HP:0001177)1.80727481
160Abnormality of the middle phalanges of the toes (HP:0010183)1.80635713
161Omphalocele (HP:0001539)1.80273178
162Congenital, generalized hypertrichosis (HP:0004540)1.79737481
163Oligodactyly (hands) (HP:0001180)1.79243442
164Absent septum pellucidum (HP:0001331)1.78250695
165Patchy hypopigmentation of hair (HP:0011365)1.78232773
166Rib fusion (HP:0000902)1.78081655
167Holoprosencephaly (HP:0001360)1.77467862
168Neoplasm of striated muscle (HP:0009728)1.76402140
169Aplasia/Hypoplasia of the fibula (HP:0006492)1.76227730
170Hemivertebrae (HP:0002937)1.76162413
171Vaginal atresia (HP:0000148)1.76157772
172Sparse lateral eyebrow (HP:0005338)1.75958794
173Thyroid-stimulating hormone excess (HP:0002925)1.75462998
174Genital tract atresia (HP:0001827)1.75094624
175Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.74553062
176Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71685935
177Focal seizures (HP:0007359)1.71602478
178Aplasia/Hypoplasia of the uvula (HP:0010293)1.71379132
179Chorioretinal atrophy (HP:0000533)1.71248311
180Congenital sensorineural hearing impairment (HP:0008527)1.70658660
181Genu varum (HP:0002970)1.69579531
182Osteomalacia (HP:0002749)1.69285055
183Gonadotropin excess (HP:0000837)1.68123354
184Abnormality of the 2nd finger (HP:0004100)1.66309373
185Maternal diabetes (HP:0009800)1.65435248
186Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.64857873
187Hypoplasia of the ulna (HP:0003022)1.63849713
188Hyperventilation (HP:0002883)1.63721406
189Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.63415890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR25.07430191
2ADRBK23.56418671
3MARK13.47801986
4EPHA43.33564536
5DDR23.18077244
6GRK12.91049077
7FRK2.55082644
8LATS12.50837324
9NTRK32.48451706
10CASK2.37051497
11WNK32.25246572
12MAP4K22.21877060
13TIE12.21635228
14SIK32.11982225
15PINK12.07732379
16MAP3K42.05630886
17KSR12.01623227
18MAP3K91.97566742
19BMPR1B1.95243795
20CDC71.93605651
21LATS21.92066963
22SIK21.87738776
23DAPK21.87661853
24VRK21.82776927
25NTRK21.81991784
26TAF11.80694712
27FGFR11.79695491
28EPHB21.78673114
29CAMK1G1.78058010
30PDGFRA1.75452746
31MAP2K71.70965238
32MINK11.70204509
33MKNK21.67131355
34PIK3CA1.66149069
35MKNK11.65048971
36ZAK1.62894271
37MAPK151.55665411
38VRK11.55561141
39MAP2K41.55237562
40MAP3K121.52756830
41PAK61.46508186
42TLK11.42653585
43PLK21.39264909
44PNCK1.36860897
45PRKD31.36580966
46MAPK131.31915020
47DYRK31.29974540
48FER1.26446650
49SIK11.25864189
50INSRR1.24685963
51DYRK21.21441425
52CSNK1G31.16691560
53NTRK11.14994955
54CDK51.10640150
55CAMK1D1.10593657
56AKT31.10124259
57PRKD21.09472119
58TAOK31.06042461
59TYRO31.05583287
60MARK21.02545642
61UHMK10.99618573
62ICK0.98046760
63CDK190.96869022
64DMPK0.96320451
65WNK40.94448600
66PDGFRB0.93991020
67RET0.92779736
68BMX0.89650180
69DAPK10.89517533
70CAMK40.89272597
71CSNK1A1L0.88474938
72ACVR1B0.83313224
73NUAK10.82792474
74TGFBR10.82455642
75ERBB30.79463620
76NLK0.78187673
77MAP3K60.74503912
78PHKG10.74282909
79PHKG20.74282909
80BCR0.73771669
81PKN10.73676100
82PRPF4B0.71684016
83MAP3K70.69190451
84TAOK10.69101414
85ADRBK10.69044692
86STK160.68854950
87PRKCE0.68203079
88CAMK10.65379758
89OXSR10.64834357
90BRD40.64673705
91CDC42BPA0.64063924
92STK110.64039990
93CDK180.63562742
94CSNK1G20.63278513
95SGK2230.63011119
96SGK4940.63011119
97RIPK10.62949293
98CAMKK10.62270395
99CLK10.61670286
100KSR20.61540408
101CCNB10.61539049
102MAPKAPK50.60896089
103PRKCG0.60871095
104ERBB20.60613465
105CSNK1A10.60580346
106SGK30.59754535
107STK38L0.59746707
108SGK20.59631827
109BCKDK0.58727702
110GRK50.58694606
111NEK20.58644534
112SGK10.58438057
113DYRK1A0.57676144
114PAK30.57223764
115SRPK10.56278400
116TNK20.55752715
117PLK30.55673974
118STK390.55486086
119MAPK100.54524955
120ATR0.54348763
121CHEK20.54184373
122CDK150.54109488
123PRKACA0.52654466
124CDK140.51996874
125PLK10.50671052
126MAPK70.49850661
127BRSK20.48703381
128PLK40.48171324
129PRKCH0.47862071
130RPS6KA50.47286201
131ALK0.46927169
132TRIM280.46832800
133EPHA30.46768209
134PRKCZ0.46446337
135WEE10.46083672
136CAMK2A0.45207240
137AURKA0.44759237
138CDK11A0.42968420
139MAP3K20.41983383
140CSNK1G10.41250450
141TXK0.40080216
142MAPK120.39092800
143FYN0.38683371
144NME10.38402142
145GRK70.37997410
146STK30.37956369
147STK380.37186337
148MTOR0.36232115
149CSNK1D0.36173923
150TNIK0.36013716
151MAPK80.35029037
152PTK2B0.34752025
153TEC0.33036157

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.14640834
2Hedgehog signaling pathway_Homo sapiens_hsa043403.86287341
3Phototransduction_Homo sapiens_hsa047442.62292141
4Oxidative phosphorylation_Homo sapiens_hsa001902.31324518
5Wnt signaling pathway_Homo sapiens_hsa043102.29396113
6Nicotine addiction_Homo sapiens_hsa050332.23927941
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20712180
8Homologous recombination_Homo sapiens_hsa034402.06566937
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06169224
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.03382849
11Axon guidance_Homo sapiens_hsa043601.98079945
12Parkinsons disease_Homo sapiens_hsa050121.91872099
13Circadian entrainment_Homo sapiens_hsa047131.89436078
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.88599497
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85370415
16Amphetamine addiction_Homo sapiens_hsa050311.83075298
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.81282645
18Ribosome_Homo sapiens_hsa030101.78923188
19Long-term potentiation_Homo sapiens_hsa047201.77451622
20Fanconi anemia pathway_Homo sapiens_hsa034601.76906905
21Glutamatergic synapse_Homo sapiens_hsa047241.74399510
22Synaptic vesicle cycle_Homo sapiens_hsa047211.73778410
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70876406
24Melanoma_Homo sapiens_hsa052181.68942296
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62588216
26Linoleic acid metabolism_Homo sapiens_hsa005911.62313715
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60153602
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60081624
29Morphine addiction_Homo sapiens_hsa050321.58878748
30Hippo signaling pathway_Homo sapiens_hsa043901.57965608
31Selenocompound metabolism_Homo sapiens_hsa004501.57848629
32Renin secretion_Homo sapiens_hsa049241.55839387
33GABAergic synapse_Homo sapiens_hsa047271.55332094
34Colorectal cancer_Homo sapiens_hsa052101.54946803
35Olfactory transduction_Homo sapiens_hsa047401.54820915
36Melanogenesis_Homo sapiens_hsa049161.52989509
37Dopaminergic synapse_Homo sapiens_hsa047281.52321100
38Nitrogen metabolism_Homo sapiens_hsa009101.51801049
39Cholinergic synapse_Homo sapiens_hsa047251.50803434
40cAMP signaling pathway_Homo sapiens_hsa040241.50660498
41Protein export_Homo sapiens_hsa030601.48485280
42Tryptophan metabolism_Homo sapiens_hsa003801.47344180
43Glioma_Homo sapiens_hsa052141.42323361
44ErbB signaling pathway_Homo sapiens_hsa040121.41609825
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41460224
46Cocaine addiction_Homo sapiens_hsa050301.40683244
47Cardiac muscle contraction_Homo sapiens_hsa042601.39783522
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38895403
49Basal transcription factors_Homo sapiens_hsa030221.38609652
50Huntingtons disease_Homo sapiens_hsa050161.37984759
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36127955
52Insulin secretion_Homo sapiens_hsa049111.33797616
53Type II diabetes mellitus_Homo sapiens_hsa049301.33098847
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32676054
55Alzheimers disease_Homo sapiens_hsa050101.32051142
56TGF-beta signaling pathway_Homo sapiens_hsa043501.30530609
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29995499
58Oxytocin signaling pathway_Homo sapiens_hsa049211.27038186
59Salivary secretion_Homo sapiens_hsa049701.26994816
60Dilated cardiomyopathy_Homo sapiens_hsa054141.24848841
61Gap junction_Homo sapiens_hsa045401.23731126
62Pathways in cancer_Homo sapiens_hsa052001.23172970
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22883251
64Endometrial cancer_Homo sapiens_hsa052131.22522433
65RNA polymerase_Homo sapiens_hsa030201.22474932
66Butanoate metabolism_Homo sapiens_hsa006501.21012828
67ECM-receptor interaction_Homo sapiens_hsa045121.18545129
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16697302
69Adherens junction_Homo sapiens_hsa045201.16455756
70Long-term depression_Homo sapiens_hsa047301.15848055
71Retinol metabolism_Homo sapiens_hsa008301.13388161
72Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11268441
73Sulfur metabolism_Homo sapiens_hsa009201.11214958
74Gastric acid secretion_Homo sapiens_hsa049711.11050195
75Chemical carcinogenesis_Homo sapiens_hsa052041.09950936
76GnRH signaling pathway_Homo sapiens_hsa049121.09619505
77MAPK signaling pathway_Homo sapiens_hsa040101.08357758
78Estrogen signaling pathway_Homo sapiens_hsa049151.07449872
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07327877
80Vitamin digestion and absorption_Homo sapiens_hsa049771.07147097
81Prostate cancer_Homo sapiens_hsa052151.06782670
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03366945
83Rap1 signaling pathway_Homo sapiens_hsa040151.01695006
84cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01333701
85Proteoglycans in cancer_Homo sapiens_hsa052051.01062065
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00566879
87Calcium signaling pathway_Homo sapiens_hsa040201.00293010
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99267531
89Serotonergic synapse_Homo sapiens_hsa047260.98565072
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97487319
91Ether lipid metabolism_Homo sapiens_hsa005650.97101236
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96321860
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95575910
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94281459
95Ras signaling pathway_Homo sapiens_hsa040140.92964970
96Focal adhesion_Homo sapiens_hsa045100.90465433
97Taste transduction_Homo sapiens_hsa047420.90321178
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89578648
99RNA degradation_Homo sapiens_hsa030180.85922487
100Systemic lupus erythematosus_Homo sapiens_hsa053220.85464646
101Oocyte meiosis_Homo sapiens_hsa041140.83140735
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82387155
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82257501
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81552399
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.80698013
106Choline metabolism in cancer_Homo sapiens_hsa052310.80190488
107Alcoholism_Homo sapiens_hsa050340.80146831
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80085936
109Steroid biosynthesis_Homo sapiens_hsa001000.78822371
110Caffeine metabolism_Homo sapiens_hsa002320.78245578
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77179069
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77173196
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76053604
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.75872325
115Renal cell carcinoma_Homo sapiens_hsa052110.74370960
116Propanoate metabolism_Homo sapiens_hsa006400.73229282
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.70201314
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.70097511
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70034492
120mTOR signaling pathway_Homo sapiens_hsa041500.69100578
121MicroRNAs in cancer_Homo sapiens_hsa052060.68783097
122Fat digestion and absorption_Homo sapiens_hsa049750.67503536
123Non-small cell lung cancer_Homo sapiens_hsa052230.67164353
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66042775
125AMPK signaling pathway_Homo sapiens_hsa041520.64557731
126Peroxisome_Homo sapiens_hsa041460.64482314
127Protein digestion and absorption_Homo sapiens_hsa049740.64349424
128Chronic myeloid leukemia_Homo sapiens_hsa052200.63784794
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63635010
130Viral myocarditis_Homo sapiens_hsa054160.63019203
131Nucleotide excision repair_Homo sapiens_hsa034200.62662721
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62255033
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.61530542
134Ovarian steroidogenesis_Homo sapiens_hsa049130.61151873
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58697927
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.58505817
137Amoebiasis_Homo sapiens_hsa051460.57979705
138DNA replication_Homo sapiens_hsa030300.55677005
139Arachidonic acid metabolism_Homo sapiens_hsa005900.54759871
140Lysine degradation_Homo sapiens_hsa003100.54575810
141VEGF signaling pathway_Homo sapiens_hsa043700.53848701
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52815219
143Small cell lung cancer_Homo sapiens_hsa052220.52795500
144Glycerolipid metabolism_Homo sapiens_hsa005610.51901484
145Insulin signaling pathway_Homo sapiens_hsa049100.51882130
146Dorso-ventral axis formation_Homo sapiens_hsa043200.51577009
147Pancreatic cancer_Homo sapiens_hsa052120.51240221
148Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49633085
149Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49198620
150Regulation of autophagy_Homo sapiens_hsa041400.47645366
151Purine metabolism_Homo sapiens_hsa002300.46554978
152Glucagon signaling pathway_Homo sapiens_hsa049220.46168147
153Mismatch repair_Homo sapiens_hsa034300.45756744
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45686620
155Collecting duct acid secretion_Homo sapiens_hsa049660.45499098
156Circadian rhythm_Homo sapiens_hsa047100.45007037
157Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44418626
158Sphingolipid signaling pathway_Homo sapiens_hsa040710.44123283
159Spliceosome_Homo sapiens_hsa030400.44037651
160Adipocytokine signaling pathway_Homo sapiens_hsa049200.41598704
161Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41002582
162Thyroid hormone synthesis_Homo sapiens_hsa049180.38759865
163Non-homologous end-joining_Homo sapiens_hsa034500.37728020
164Metabolic pathways_Homo sapiens_hsa011000.37118949

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »