SCUBE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)6.35276729
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.64399454
3myofibril assembly (GO:0030239)5.40114224
4sarcomere organization (GO:0045214)5.38340991
5keratan sulfate catabolic process (GO:0042340)5.01118493
6cardiac muscle cell development (GO:0055013)4.88951447
7negative regulation of potassium ion transmembrane transport (GO:1901380)4.80345859
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.73202630
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.68230173
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.64288635
11ear development (GO:0043583)4.63354374
12insulin-like growth factor receptor signaling pathway (GO:0048009)4.62118734
13cardiac cell development (GO:0055006)4.59564217
14cardiac muscle tissue morphogenesis (GO:0055008)4.37068076
15chondrocyte development (GO:0002063)4.31268227
16regulation of cardioblast differentiation (GO:0051890)4.25154032
17ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.21969815
18cardiac muscle contraction (GO:0060048)4.17686414
19notochord development (GO:0030903)4.16762337
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.15867767
21plasma membrane repair (GO:0001778)4.12765405
22muscle tissue morphogenesis (GO:0060415)4.08213486
23regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.05192145
24muscle filament sliding (GO:0030049)4.01012504
25actin-myosin filament sliding (GO:0033275)4.01012504
26cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.88219971
27cartilage condensation (GO:0001502)3.85252754
28cell aggregation (GO:0098743)3.85252754
29regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.82216739
30negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.80174132
31actomyosin structure organization (GO:0031032)3.77330489
32protein hydroxylation (GO:0018126)3.76012204
33striated muscle hypertrophy (GO:0014897)3.75389386
34branching involved in salivary gland morphogenesis (GO:0060445)3.74699761
35adult heart development (GO:0007512)3.73991888
36ventricular cardiac muscle cell action potential (GO:0086005)3.69234830
37peptidyl-proline hydroxylation (GO:0019511)3.67996020
38semaphorin-plexin signaling pathway (GO:0071526)3.67685477
39regulation of sarcomere organization (GO:0060297)3.66957679
40regulation of actin filament-based movement (GO:1903115)3.66533370
41ventricular cardiac muscle cell development (GO:0055015)3.63434591
42artery development (GO:0060840)3.62969735
43limb bud formation (GO:0060174)3.62369204
44cardiac muscle hypertrophy (GO:0003300)3.60165090
45endocrine hormone secretion (GO:0060986)3.54982356
46cell wall macromolecule catabolic process (GO:0016998)3.53206037
47cell wall macromolecule metabolic process (GO:0044036)3.53206037
48negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.48335424
49heart trabecula formation (GO:0060347)3.48131530
50hemidesmosome assembly (GO:0031581)3.47332555
51collagen fibril organization (GO:0030199)3.46388111
52regulation of skeletal muscle contraction (GO:0014819)3.42025171
53branching involved in prostate gland morphogenesis (GO:0060442)3.39694589
54regulation of relaxation of muscle (GO:1901077)3.35621496
55actin-mediated cell contraction (GO:0070252)3.35393722
56negative regulation of striated muscle cell apoptotic process (GO:0010664)3.34947236
57regulation of establishment or maintenance of cell polarity (GO:0032878)3.33394775
58muscle hypertrophy (GO:0014896)3.33292329
59cardiac right ventricle morphogenesis (GO:0003215)3.32613114
60positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.30297706
61atrioventricular valve morphogenesis (GO:0003181)3.30206936
62regulation of cell communication by electrical coupling (GO:0010649)3.29851841
63cell communication involved in cardiac conduction (GO:0086065)3.27906793
64desmosome organization (GO:0002934)3.26993628
65endothelial cell chemotaxis (GO:0035767)3.26038073
66acrosome reaction (GO:0007340)3.24793764
67intestinal epithelial cell development (GO:0060576)3.24430290
68lymph vessel development (GO:0001945)3.24053112
69regulation of the force of heart contraction (GO:0002026)3.23290061
70dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.22706063
71tricarboxylic acid cycle (GO:0006099)3.21067975
72endothelial cell morphogenesis (GO:0001886)3.20882443
73ovulation from ovarian follicle (GO:0001542)3.20486372
74negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.18719376
75polarized epithelial cell differentiation (GO:0030859)3.18260170
76regulation of striated muscle contraction (GO:0006942)3.16029290
77positive regulation of fatty acid beta-oxidation (GO:0032000)3.15818938
78glomerular filtration (GO:0003094)3.15004403
79otic vesicle formation (GO:0030916)3.14366219
80apical protein localization (GO:0045176)3.12438110
81striated muscle contraction (GO:0006941)3.10408603
82retina vasculature morphogenesis in camera-type eye (GO:0061299)3.09215076
83fusion of sperm to egg plasma membrane (GO:0007342)3.08163698
84regulation of axon extension involved in axon guidance (GO:0048841)3.07683438
85protein heterotrimerization (GO:0070208)3.07314985
86regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.06988110
87trabecula formation (GO:0060343)3.05712825
88regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.05354304
89regulation of fatty acid beta-oxidation (GO:0031998)3.05168845
90vascular endothelial growth factor signaling pathway (GO:0038084)3.04674762
91regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.04440903
92cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.04211336
93cell proliferation involved in metanephros development (GO:0072203)3.01847174
94bone trabecula formation (GO:0060346)3.01583452
95cell migration involved in heart development (GO:0060973)3.00281724
96regulation of water loss via skin (GO:0033561)2.99377641
97glomerular basement membrane development (GO:0032836)2.95550643
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93676947
99regulation of cell proliferation involved in kidney development (GO:1901722)2.92449121
100heart process (GO:0003015)2.92222136
101heart contraction (GO:0060047)2.92222136
102norepinephrine metabolic process (GO:0042415)2.90913545
103endocardial cushion morphogenesis (GO:0003203)2.89936535
104regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84623957
105response to BMP (GO:0071772)2.83395660
106cellular response to BMP stimulus (GO:0071773)2.83395660
107negative regulation of cell size (GO:0045792)2.81812146
108regulation of cardiac muscle contraction (GO:0055117)2.81191738
109epithelial cell-cell adhesion (GO:0090136)2.80340437
110negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.80250939
111cardiac muscle cell action potential (GO:0086001)2.79141104
112establishment of apical/basal cell polarity (GO:0035089)2.78974204
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.78849653
114embryonic heart tube development (GO:0035050)2.78801590
115positive regulation of chondrocyte differentiation (GO:0032332)2.78798802
116cardiac muscle cell action potential involved in contraction (GO:0086002)2.78267626
117lymphangiogenesis (GO:0001946)2.77131932
118regulation of striated muscle cell apoptotic process (GO:0010662)2.76663786
119renal filtration (GO:0097205)2.76392602
120dermatan sulfate metabolic process (GO:0030205)2.75920738
121gonadal mesoderm development (GO:0007506)2.75618518
122heart morphogenesis (GO:0003007)2.75389790
123multicellular organismal water homeostasis (GO:0050891)2.74550390
124cell communication by electrical coupling (GO:0010644)2.73476015
125sarcoplasmic reticulum calcium ion transport (GO:0070296)2.73382373
126heart valve formation (GO:0003188)2.72910192
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72244704
128embryonic skeletal joint morphogenesis (GO:0060272)2.71769740
129striated muscle cell development (GO:0055002)2.71314747
130mesonephros development (GO:0001823)2.69416049
131regulation of establishment of cell polarity (GO:2000114)2.69039574
132outflow tract septum morphogenesis (GO:0003148)2.68936736
133basement membrane organization (GO:0071711)2.66401489
134response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.65773568
135atrial septum morphogenesis (GO:0060413)2.65550996
136prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.65494928
137COPI coating of Golgi vesicle (GO:0048205)2.62725017
138Golgi transport vesicle coating (GO:0048200)2.62725017
139face development (GO:0060324)2.62625507
140regulation of hippo signaling (GO:0035330)2.62100564
141organ formation (GO:0048645)2.61749170
142regulation of membrane repolarization (GO:0060306)2.61360730
143cardiac muscle adaptation (GO:0014887)2.61239929
144cardiac muscle hypertrophy in response to stress (GO:0014898)2.61239929
145muscle hypertrophy in response to stress (GO:0003299)2.61239929
146asymmetric protein localization (GO:0008105)2.60292708
147regulation of axon guidance (GO:1902667)2.58389237
148exocrine pancreas development (GO:0031017)2.57492284
149striated muscle atrophy (GO:0014891)2.56862747
150positive regulation of keratinocyte differentiation (GO:0045618)2.55130737
151negative regulation of axon extension involved in axon guidance (GO:0048843)2.51929636
152regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.50897806
153regulation of protein localization to cell surface (GO:2000008)2.50599818
154positive regulation of fatty acid oxidation (GO:0046321)2.50452321
155embryonic retina morphogenesis in camera-type eye (GO:0060059)2.49780905
156phosphatidylinositol 3-kinase signaling (GO:0014065)2.49623417
157cell-cell junction maintenance (GO:0045217)2.48870192
158mammary gland epithelial cell differentiation (GO:0060644)2.48776215
159regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48353317
160white fat cell differentiation (GO:0050872)2.47826653
161biotin metabolic process (GO:0006768)2.45902085
162regulation of ruffle assembly (GO:1900027)2.45637943
163epithelial cell maturation (GO:0002070)2.44383532
164establishment of monopolar cell polarity (GO:0061162)2.43811909
165establishment or maintenance of monopolar cell polarity (GO:0061339)2.43811909
166branching involved in mammary gland duct morphogenesis (GO:0060444)2.42958139
167regulation of clathrin-mediated endocytosis (GO:2000369)2.41411446
168peptidyl-tyrosine autophosphorylation (GO:0038083)2.41304216
169skeletal muscle adaptation (GO:0043501)2.41215034
170positive regulation of glycogen biosynthetic process (GO:0045725)2.39176140
171surfactant homeostasis (GO:0043129)2.37066363
172cellular zinc ion homeostasis (GO:0006882)2.36961103
173vagina development (GO:0060068)2.36360001
174neuron projection extension involved in neuron projection guidance (GO:1902284)2.36039521
175axon extension involved in axon guidance (GO:0048846)2.36039521
176quaternary ammonium group transport (GO:0015697)2.34932012
177establishment of skin barrier (GO:0061436)2.33789612
178regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.33564537
179maternal placenta development (GO:0001893)2.32824453
180macroautophagy (GO:0016236)2.32714978
181regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.32684670
182cell junction maintenance (GO:0034331)2.32419963
183cytoskeletal anchoring at plasma membrane (GO:0007016)2.30278862
184cardiac ventricle morphogenesis (GO:0003208)2.29699859
185lung lobe morphogenesis (GO:0060463)2.29037338
186glucocorticoid biosynthetic process (GO:0006704)2.28819580
187adherens junction assembly (GO:0034333)2.28515842
188facial nerve structural organization (GO:0021612)2.28118341
189toxin transport (GO:1901998)2.26519094
190water homeostasis (GO:0030104)2.26170023
191regulation of glomerular filtration (GO:0003093)2.26112348
192neuromuscular junction development (GO:0007528)2.24036656
193extracellular matrix assembly (GO:0085029)2.23090613
194negative regulation of endothelial cell apoptotic process (GO:2000352)2.23026909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.53945837
2EZH2_22144423_ChIP-Seq_EOC_Human3.66119305
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.60232705
4TFAP2C_20629094_ChIP-Seq_MCF-7_Human3.18370504
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.43069097
6* TBX20_22328084_ChIP-Seq_HEART_Mouse2.40431270
7* TBX20_22080862_ChIP-Seq_HEART_Mouse2.40431270
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.40362361
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.34265262
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.18794570
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13876019
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.13831707
13ZNF263_19887448_ChIP-Seq_K562_Human2.10712387
14DROSHA_22980978_ChIP-Seq_HELA_Human2.10585298
15RACK7_27058665_Chip-Seq_MCF-7_Human1.96322654
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95478517
17ZNF274_21170338_ChIP-Seq_K562_Hela1.91543136
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91521696
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91493466
20GATA1_22025678_ChIP-Seq_K562_Human1.90060858
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89396655
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.89214163
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86919013
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77812608
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.76821592
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.76654469
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.74572565
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71441962
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66817694
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66551425
31CJUN_26792858_Chip-Seq_BT549_Human1.62976060
32VDR_22108803_ChIP-Seq_LS180_Human1.62644687
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60929990
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60752107
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59135655
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.58870776
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.58760076
38GATA3_24758297_ChIP-Seq_MCF-7_Human1.58463017
39MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.55630592
40ISL1_27105846_Chip-Seq_CPCs_Mouse1.52631403
41* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50506288
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.50236227
43SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49783200
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49596359
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46486472
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43552399
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.40353661
48CLOCK_20551151_ChIP-Seq_293T_Human1.36408206
49KDM2B_26808549_Chip-Seq_K562_Human1.36044188
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35754198
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35515592
52TBX3_20139965_ChIP-Seq_ESCs_Mouse1.33664540
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.31549317
54TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31418867
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30996363
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.30183132
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29470993
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29111777
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27270275
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25970906
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24770873
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22861463
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22447350
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21661033
65LXR_22292898_ChIP-Seq_THP-1_Human1.19906183
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19346807
67AHR_22903824_ChIP-Seq_MCF-7_Human1.19342391
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17832921
69* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17823626
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17199284
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16382280
72KLF5_25053715_ChIP-Seq_YYC3_Human1.16166115
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15656045
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.15466658
75CTCF_27219007_Chip-Seq_Bcells_Human1.15163449
76* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13525895
77* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13525895
78* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12174779
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.11638845
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11436017
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11003522
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09800585
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09063562
84CREB1_26743006_Chip-Seq_LNCaP_Human1.08715714
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08430909
86P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08071638
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05690271
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04355463
89* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03679977
90TP53_20018659_ChIP-ChIP_R1E_Mouse1.02064260
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01481581
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00994284
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.00428042
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00134895
95* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99965589
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99638986
97GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98860951
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.98580989
99SMC4_20622854_ChIP-Seq_HELA_Human0.98562367
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.97575353
101TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96579534
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95716251
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.95532143
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95478224
105* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95387781
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95006420
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94704722
108TET1_21490601_ChIP-Seq_MESCs_Mouse0.94652236
109TP63_22573176_ChIP-Seq_HFKS_Human0.93872587
110AR_21572438_ChIP-Seq_LNCaP_Human0.93659771
111ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93377812
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.92152000
113RUNX1_27514584_Chip-Seq_MCF-7_Human0.91806351
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91786457
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91080672
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90936160
117YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90500867
118* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90214391
119ELK3_25401928_ChIP-Seq_HUVEC_Human0.90059031
120SMAD4_21799915_ChIP-Seq_A2780_Human0.90014606
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89608478
122* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89269064
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88889111
124SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88771817
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88771817
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88497997
127GATA6_25053715_ChIP-Seq_YYC3_Human0.88488156
128ER_23166858_ChIP-Seq_MCF-7_Human0.87948496
129* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87635830
130BCAT_22108803_ChIP-Seq_LS180_Human0.87155293
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.86892087
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.86329766
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85745971
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85532975
135RING1B_27294783_Chip-Seq_ESCs_Mouse0.84616977
136GBX2_23144817_ChIP-Seq_PC3_Human0.84408769
137BRD4_25478319_ChIP-Seq_HGPS_Human0.83411365
138SUZ12_27294783_Chip-Seq_ESCs_Mouse0.83336633
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83299589
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.82838061
141DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82722915
142BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82637646
143NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81561114
144TP53_23651856_ChIP-Seq_MEFs_Mouse0.81492668
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.80805168
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80154575
147MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80133432
148SOX2_21211035_ChIP-Seq_LN229_Gbm0.79829804
149PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79337495
150P68_20966046_ChIP-Seq_HELA_Human0.78952001
151RXR_22158963_ChIP-Seq_LIVER_Mouse0.78752300
152PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78506924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.46754135
2MP0000751_myopathy4.31537365
3MP0004084_abnormal_cardiac_muscle4.08017658
4MP0002837_dystrophic_cardiac_calcinosis3.74936300
5MP0002254_reproductive_system_inflammat3.56537670
6MP0005503_abnormal_tendon_morphology3.23445691
7MP0004264_abnormal_extraembryonic_tissu3.10024657
8MP0004215_abnormal_myocardial_fiber3.08454968
9MP0004036_abnormal_muscle_relaxation2.84198158
10MP0005330_cardiomyopathy2.76190998
11MP0002282_abnormal_trachea_morphology2.66129477
12MP0000749_muscle_degeneration2.62683697
13MP0004272_abnormal_basement_membrane2.62511099
14MP0005275_abnormal_skin_tensile2.60085663
15MP0008438_abnormal_cutaneous_collagen2.55819315
16MP0006138_congestive_heart_failure2.46451732
17MP0003137_abnormal_impulse_conducting2.37124501
18MP0000750_abnormal_muscle_regeneration2.26716039
19MP0002796_impaired_skin_barrier2.18871566
20MP0004484_altered_response_of2.18155410
21MP0005409_darkened_coat_color2.16989128
22MP0002972_abnormal_cardiac_muscle2.11736253
23MP0004087_abnormal_muscle_fiber2.11221617
24MP0003941_abnormal_skin_development2.11177547
25MP0005670_abnormal_white_adipose2.05799723
26MP0003828_pulmonary_edema2.05143353
27MP0000383_abnormal_hair_follicle2.03823073
28MP0005385_cardiovascular_system_phenoty2.03049827
29MP0001544_abnormal_cardiovascular_syste2.03049827
30MP0001849_ear_inflammation2.02459484
31MP0005410_abnormal_fertilization1.97452357
32MP0010630_abnormal_cardiac_muscle1.91859217
33MP0002108_abnormal_muscle_morphology1.90206264
34MP0005076_abnormal_cell_differentiation1.88947736
35MP0008775_abnormal_heart_ventricle1.87635042
36MP0000462_abnormal_digestive_system1.84287913
37MP0009250_abnormal_appendicular_skeleto1.82885234
38MP0002876_abnormal_thyroid_physiology1.81398480
39MP0005083_abnormal_biliary_tract1.80057795
40MP0004085_abnormal_heartbeat1.78237405
41MP0004134_abnormal_chest_morphology1.74341617
42MP0004381_abnormal_hair_follicle1.73884489
43MP0005058_abnormal_lysosome_morphology1.71833680
44MP0002106_abnormal_muscle_physiology1.69583109
45MP0001958_emphysema1.68524061
46MP0002098_abnormal_vibrissa_morphology1.67829646
47MP0004185_abnormal_adipocyte_glucose1.66878878
48MP0005369_muscle_phenotype1.66866952
49MP0005666_abnormal_adipose_tissue1.66158859
50MP0005620_abnormal_muscle_contractility1.65157960
51MP0005248_abnormal_Harderian_gland1.63276845
52MP0005623_abnormal_meninges_morphology1.62382472
53MP0000762_abnormal_tongue_morphology1.62089422
54MP0004145_abnormal_muscle_electrophysio1.58690291
55MP0002269_muscular_atrophy1.56823648
56MP0001299_abnormal_eye_distance/1.56768892
57MP0010030_abnormal_orbit_morphology1.55086866
58MP0004858_abnormal_nervous_system1.51133845
59MP0003567_abnormal_fetal_cardiomyocyte1.48279415
60MP0005508_abnormal_skeleton_morphology1.45960758
61MP0002127_abnormal_cardiovascular_syste1.42656006
62MP0002234_abnormal_pharynx_morphology1.39366195
63MP0000759_abnormal_skeletal_muscle1.38635649
64MP0010678_abnormal_skin_adnexa1.36852112
65MP0005375_adipose_tissue_phenotype1.36766092
66MP0000163_abnormal_cartilage_morphology1.35921986
67MP0010368_abnormal_lymphatic_system1.34779070
68MP0000013_abnormal_adipose_tissue1.33930309
69MP0000427_abnormal_hair_cycle1.33546216
70MP0005257_abnormal_intraocular_pressure1.32457986
71MP0003705_abnormal_hypodermis_morpholog1.31815117
72MP0004233_abnormal_muscle_weight1.31686416
73MP0000537_abnormal_urethra_morphology1.26839217
74MP0002932_abnormal_joint_morphology1.24402646
75MP0002896_abnormal_bone_mineralization1.22834911
76MP0003221_abnormal_cardiomyocyte_apopto1.22810796
77MP0003566_abnormal_cell_adhesion1.22114659
78MP0002822_catalepsy1.17990495
79MP0003283_abnormal_digestive_organ1.16815789
80MP0002089_abnormal_postnatal_growth/wei1.15499851
81MP0009384_cardiac_valve_regurgitation1.15294376
82MP0000747_muscle_weakness1.13729021
83MP0002060_abnormal_skin_morphology1.13348200
84MP0003279_aneurysm1.11905846
85MP0000627_abnormal_mammary_gland1.10257956
86MP0005377_hearing/vestibular/ear_phenot1.09146557
87MP0003878_abnormal_ear_physiology1.09146557
88MP0001879_abnormal_lymphatic_vessel1.08634815
89MP0003755_abnormal_palate_morphology1.08411549
90MP0003935_abnormal_craniofacial_develop1.08178757
91MP0000377_abnormal_hair_follicle1.08142526
92MP0000767_abnormal_smooth_muscle1.07818599
93MP0000049_abnormal_middle_ear1.07476734
94MP0000266_abnormal_heart_morphology1.06962883
95MP0001502_abnormal_circadian_rhythm1.05922279
96MP0000003_abnormal_adipose_tissue1.05753614
97MP0009780_abnormal_chondrocyte_physiolo1.05603004
98MP0000428_abnormal_craniofacial_morphol1.03970348
99MP0005595_abnormal_vascular_smooth1.01949420
100MP0002933_joint_inflammation1.01685707
101MP0002249_abnormal_larynx_morphology1.01565614
102MP0003385_abnormal_body_wall1.00269148
103MP0005501_abnormal_skin_physiology0.99605554
104MP0002115_abnormal_skeleton_extremities0.99055637
105MP0003936_abnormal_reproductive_system0.98643149
106MP0010329_abnormal_lipoprotein_level0.98240666
107MP0005408_hypopigmentation0.97009115
108MP0000467_abnormal_esophagus_morphology0.94566798
109MP0004782_abnormal_surfactant_physiolog0.93724894
110MP0003950_abnormal_plasma_membrane0.93656186
111MP0004270_analgesia0.93647836
112MP0000534_abnormal_ureter_morphology0.92716629
113MP0003183_abnormal_peptide_metabolism0.92631539
114MP0002113_abnormal_skeleton_development0.92195851
115MP0001270_distended_abdomen0.91685955
116MP0003115_abnormal_respiratory_system0.90533077
117MP0002653_abnormal_ependyma_morphology0.90289137
118MP0010234_abnormal_vibrissa_follicle0.90054758
119MP0002116_abnormal_craniofacial_bone0.89466366
120MP0005646_abnormal_pituitary_gland0.88370864
121MP0002751_abnormal_autonomic_nervous0.87783917
122MP0000432_abnormal_head_morphology0.87531498
123MP0000343_altered_response_to0.87109868
124MP0002925_abnormal_cardiovascular_devel0.86871558
125MP0000371_diluted_coat_color0.86817601
126MP0002332_abnormal_exercise_endurance0.86519716
127MP0005187_abnormal_penis_morphology0.86477069
128MP0002128_abnormal_blood_circulation0.85011415
129MP0003937_abnormal_limbs/digits/tail_de0.84670946
130MP0003122_maternal_imprinting0.84399645
131MP0002109_abnormal_limb_morphology0.84226606
132MP0003942_abnormal_urinary_system0.82709305
133MP0001881_abnormal_mammary_gland0.80621352
134MP0000681_abnormal_thyroid_gland0.80440940
135MP0009115_abnormal_fat_cell0.80035924
136MP0000538_abnormal_urinary_bladder0.79722755
137MP0004197_abnormal_fetal_growth/weight/0.79520301
138MP0004130_abnormal_muscle_cell0.78167955
139MP0003119_abnormal_digestive_system0.77418353
140MP0010771_integument_phenotype0.76261272
141MP0001177_atelectasis0.75280029
142MP0002295_abnormal_pulmonary_circulatio0.74674130
143MP0005367_renal/urinary_system_phenotyp0.74559959
144MP0000516_abnormal_urinary_system0.74559959
145MP0003638_abnormal_response/metabolism_0.73102739
146MP0001664_abnormal_digestion0.72986107
147MP0003938_abnormal_ear_development0.71844300
148MP0003191_abnormal_cellular_cholesterol0.71374520
149MP0000733_abnormal_muscle_development0.71320804
150MP0005390_skeleton_phenotype0.70168576
151MP0002971_abnormal_brown_adipose0.70158891
152MP0003091_abnormal_cell_migration0.70012794
153MP0005167_abnormal_blood-brain_barrier0.69594129
154MP0000026_abnormal_inner_ear0.68483164
155MP0000566_synostosis0.67763871
156MP0002909_abnormal_adrenal_gland0.67435808
157MP0002133_abnormal_respiratory_system0.66687742
158MP0005388_respiratory_system_phenotype0.66687742
159MP0000579_abnormal_nail_morphology0.65983049
160MP0009840_abnormal_foam_cell0.64820929
161MP0001784_abnormal_fluid_regulation0.64466302
162MP0003136_yellow_coat_color0.63470766
163MP0002075_abnormal_coat/hair_pigmentati0.63099559

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)5.92845909
2Hypoplastic ischia (HP:0003175)5.61025077
3Abnormality of the ischium (HP:0003174)4.97402836
4Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.77114384
5Sudden death (HP:0001699)4.70991740
6Epiphyseal dysplasia (HP:0002656)4.69119755
7Vitreoretinal degeneration (HP:0000655)4.65048964
8Irregular epiphyses (HP:0010582)4.44722535
9Ventricular tachycardia (HP:0004756)4.28902942
10Muscle fiber splitting (HP:0003555)4.05218996
11Deformed sella turcica (HP:0002681)3.91018411
12Lymphangioma (HP:0100764)3.90717208
13Flat capital femoral epiphysis (HP:0003370)3.89169000
14Abnormality of the calf musculature (HP:0001430)3.86714717
15Atrial fibrillation (HP:0005110)3.85578576
16Broad face (HP:0000283)3.83898269
17Abnormal tarsal ossification (HP:0008369)3.73574241
18Calf muscle hypertrophy (HP:0008981)3.71867805
19Aortic regurgitation (HP:0001659)3.67067493
20Primary atrial arrhythmia (HP:0001692)3.61449096
21Obstructive sleep apnea (HP:0002870)3.60816275
22Cupped ribs (HP:0000887)3.55263011
23Supraventricular tachycardia (HP:0004755)3.47733864
24Supraventricular arrhythmia (HP:0005115)3.47100581
25Neonatal short-limb short stature (HP:0008921)3.45872881
26Flat acetabular roof (HP:0003180)3.44509549
27Right ventricular cardiomyopathy (HP:0011663)3.28735990
28Muscle hypertrophy of the lower extremities (HP:0008968)3.26923365
29Hip contracture (HP:0003273)3.26488280
30Lipoatrophy (HP:0100578)3.14101799
31Increased connective tissue (HP:0009025)3.12739112
32Bundle branch block (HP:0011710)3.07455067
33Limited hip movement (HP:0008800)3.06127551
34Hyporeflexia of lower limbs (HP:0002600)2.99211555
35Biconcave vertebral bodies (HP:0004586)2.99080538
36Neoplasm of the heart (HP:0100544)2.97739033
37Exercise-induced muscle cramps (HP:0003710)2.89625125
38Genu varum (HP:0002970)2.88986595
39Abnormality of the left ventricular outflow tract (HP:0011103)2.87707005
40Subaortic stenosis (HP:0001682)2.87707005
41Concave nail (HP:0001598)2.85372445
42Abnormality of the pubic bones (HP:0003172)2.82916035
43Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.81521147
44Abnormality of femoral epiphyses (HP:0006499)2.81521147
45Delayed epiphyseal ossification (HP:0002663)2.77703584
46Small epiphyses (HP:0010585)2.76285464
47Exercise-induced myalgia (HP:0003738)2.74885666
48Bronchomalacia (HP:0002780)2.71758975
49Type 1 muscle fiber predominance (HP:0003803)2.71360132
50Abnormal vertebral ossification (HP:0100569)2.70981450
51Metaphyseal cupping (HP:0003021)2.69201596
52Broad metatarsal (HP:0001783)2.65377741
53Abnormality of the sella turcica (HP:0002679)2.62515035
54Abnormality of the phalanges of the 2nd finger (HP:0009541)2.62099565
55Shallow orbits (HP:0000586)2.61120804
56Syncope (HP:0001279)2.59524825
57Abnormal foot bone ossification (HP:0010675)2.59406567
58Asymmetric septal hypertrophy (HP:0001670)2.58179559
59Prolonged QT interval (HP:0001657)2.56747067
60Cerebral aneurysm (HP:0004944)2.56154688
61Abnormality of the epiphysis of the femoral head (HP:0010574)2.55907070
62Germ cell neoplasia (HP:0100728)2.54745416
63Mildly elevated creatine phosphokinase (HP:0008180)2.52857456
64Visceral angiomatosis (HP:0100761)2.51872724
65Infantile muscular hypotonia (HP:0008947)2.49933930
66Stridor (HP:0010307)2.46252924
67Abnormal atrioventricular conduction (HP:0005150)2.41688566
68Thin bony cortex (HP:0002753)2.38568434
69EMG: myopathic abnormalities (HP:0003458)2.38194858
70Soft skin (HP:0000977)2.37329668
71Hypoplasia of the odontoid process (HP:0003311)2.36566989
72Severe Myopia (HP:0011003)2.35615565
73Flattened epiphyses (HP:0003071)2.34022223
74Spontaneous abortion (HP:0005268)2.32704182
75Dilated cardiomyopathy (HP:0001644)2.32356835
76Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.31657762
77Absent epiphyses (HP:0010577)2.31657762
78Exostoses (HP:0100777)2.29821497
79Abnormality of the 2nd finger (HP:0004100)2.29556400
80Heart block (HP:0012722)2.29491573
81Hemangiomatosis (HP:0007461)2.29277109
82Abnormality of the femoral head (HP:0003368)2.27382360
83Bladder diverticulum (HP:0000015)2.26509939
84Spinal rigidity (HP:0003306)2.22768278
85Ventricular arrhythmia (HP:0004308)2.21314313
86Difficulty climbing stairs (HP:0003551)2.21123336
87Morphological abnormality of the middle ear (HP:0008609)2.20826010
88Tracheal stenosis (HP:0002777)2.20497366
89Retinal atrophy (HP:0001105)2.18460796
90Dysostosis multiplex (HP:0000943)2.17688004
91Osteoarthritis (HP:0002758)2.16269580
92Waddling gait (HP:0002515)2.16171501
93Cervical subluxation (HP:0003308)2.15538914
94Limb-girdle muscle atrophy (HP:0003797)2.15490419
95Palpitations (HP:0001962)2.14200146
96Hyperacusis (HP:0010780)2.13773170
97Aortic valve stenosis (HP:0001650)2.13733244
98Mitral regurgitation (HP:0001653)2.13707779
99Aortic dissection (HP:0002647)2.12399629
100Mucopolysacchariduria (HP:0008155)2.11025853
101Urinary glycosaminoglycan excretion (HP:0003541)2.11025853
102Oligomenorrhea (HP:0000876)2.10492911
103Mesomelia (HP:0003027)2.08915976
104Short femoral neck (HP:0100864)2.08253695
105Abnormality of the proximal phalanges of the hand (HP:0009834)2.07644203
106Aplasia involving bones of the extremities (HP:0009825)2.06696152
107Aplasia involving bones of the upper limbs (HP:0009823)2.06696152
108Aplasia of the phalanges of the hand (HP:0009802)2.06696152
109Abnormality of the odontoid process (HP:0003310)2.06569842
110Lumbar hyperlordosis (HP:0002938)2.06475521
111Hypoplasia of the iris (HP:0007676)2.05125074
112Hyperkalemia (HP:0002153)2.03009609
113Diaphragmatic weakness (HP:0009113)2.01005905
114Distal lower limb muscle weakness (HP:0009053)2.00060453
115Atrioventricular block (HP:0001678)1.99909602
116Protrusio acetabuli (HP:0003179)1.98899215
117Flared iliac wings (HP:0002869)1.98635017
118Thin ribs (HP:0000883)1.97704228
119Abnormality of polysaccharide metabolism (HP:0011012)1.96898094
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96898094
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96898094
122Protuberant abdomen (HP:0001538)1.95070472
123Hypopigmentation of the fundus (HP:0007894)1.94830822
124Increased variability in muscle fiber diameter (HP:0003557)1.93513380
125Platyspondyly (HP:0000926)1.92549882
126Premature rupture of membranes (HP:0001788)1.92188015
127Abnormality of incisor morphology (HP:0011063)1.91088009
128Joint stiffness (HP:0001387)1.90252610
129Absent frontal sinuses (HP:0002688)1.89467542
130Renal dysplasia (HP:0000110)1.89136862
131Abnormality of the nasal septum (HP:0000419)1.89036157
132Ankle contracture (HP:0006466)1.88656990
133Enlarged penis (HP:0000040)1.88443577
134Esophageal varix (HP:0002040)1.87606982
135Myoglobinuria (HP:0002913)1.86807746
136Patent foramen ovale (HP:0001655)1.86613371
137Wide anterior fontanel (HP:0000260)1.84799078
138Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.84772017
139Abnormal delivery (HP:0001787)1.83794637
140Mild short stature (HP:0003502)1.83338976
141Keratoconus (HP:0000563)1.82891951
142Increased corneal curvature (HP:0100692)1.82891951
143Abnormality of the parietal bone (HP:0002696)1.82885436
144Follicular hyperkeratosis (HP:0007502)1.80713254
145Advanced eruption of teeth (HP:0006288)1.79499409
146Difficulty running (HP:0009046)1.78439890
147Hypoplastic left heart (HP:0004383)1.78413128
148Pulmonary artery stenosis (HP:0004415)1.78203801
149Abnormal hand bone ossification (HP:0010660)1.78020920
150Asymmetry of the thorax (HP:0001555)1.76738845
151Hyperextensible skin (HP:0000974)1.76626453
152Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75965575
153Myotonia (HP:0002486)1.75789356
154Bell-shaped thorax (HP:0001591)1.75244304
155Broad thumb (HP:0011304)1.74843156
156Abnormality of carpal bone ossification (HP:0006257)1.74061337
157Renovascular hypertension (HP:0100817)1.74037939
158Beaking of vertebral bodies (HP:0004568)1.73943053
159Atrophic scars (HP:0001075)1.73533945
160Abnormality of molar (HP:0011077)1.73095449
161Abnormality of molar morphology (HP:0011070)1.73095449
162Stage 5 chronic kidney disease (HP:0003774)1.71364476
163Abnormality of the distal phalanx of the thumb (HP:0009617)1.67481009
164Septate vagina (HP:0001153)1.64844803
165Easy fatigability (HP:0003388)1.64662550
166Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.64379352
167Aneurysm (HP:0002617)1.63837989
168Long toe (HP:0010511)1.63739272
169Tubular atrophy (HP:0000092)1.63193036
170Aplasia/hypoplasia of the femur (HP:0005613)1.62430390
171Bicornuate uterus (HP:0000813)1.61929434
172Mitral valve prolapse (HP:0001634)1.61684080
173Macroorchidism (HP:0000053)1.60822862
174Spinal cord compression (HP:0002176)1.59987222
175Wormian bones (HP:0002645)1.59910793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.19955559
2PDK34.19955559
3TTN3.74690610
4PDK23.65814586
5DDR23.13349768
6MYLK2.85815949
7LATS12.64331150
8OBSCN2.57747735
9EPHA22.56869130
10TIE12.37045643
11LMTK22.31089591
12PHKG22.23451658
13PHKG12.23451658
14DMPK2.18058572
15MAP3K32.09750097
16NEK62.03244560
17TNK21.87757000
18STK38L1.82172681
19MUSK1.79734413
20PDGFRA1.73484818
21PRKD31.67072229
22ACVR1B1.66472852
23PIK3CA1.65160931
24RPS6KB21.64130727
25AKT31.59607614
26TESK11.57833634
27EPHB21.56249960
28STK241.54640421
29ERBB21.46278760
30RIPK11.45066695
31CHUK1.44846920
32PINK11.38471397
33MAP3K61.37570899
34FGFR41.36572025
35ROCK11.36253281
36ZAK1.36197576
37NME11.34152557
38ERBB31.33663552
39TRIB31.33140828
40LATS21.28053384
41SCYL21.27155020
42TRPM71.22622521
43TGFBR11.19770827
44TYRO31.15915647
45MAP3K71.15564510
46CASK1.14966082
47CAMK41.14858062
48PKN21.14771334
49MAPK151.13951872
50ICK1.11823973
51NTRK31.10237568
52EPHA31.09100557
53SIK11.09093948
54PAK31.07818019
55RET1.02602295
56EPHB11.01083791
57FER0.99139291
58WNK40.98792526
59MAP2K20.97726626
60MAPK70.96955451
61ERN10.95974559
62BMX0.93753910
63MARK20.93720660
64PTK2B0.93087706
65PRKD10.90991050
66FRK0.90607112
67PTK20.89838398
68CDC42BPA0.83945403
69MAP3K50.79569573
70EEF2K0.78703214
71PRKD20.78313365
72PRKAA20.77046552
73MAP2K30.76447037
74DYRK1B0.75473555
75STK380.74385617
76RPS6KB10.73725132
77BMPR1B0.73378486
78MAPK120.72442576
79PDGFRB0.71638383
80MTOR0.71203293
81HIPK20.69098388
82BCR0.66155891
83STK30.65611921
84MET0.64034734
85MAPK40.63528017
86CAMK2D0.63181197
87ROCK20.61311290
88CDK120.61300600
89PAK40.60852279
90ILK0.60526633
91INSRR0.60325074
92PRKCI0.59006540
93FGFR20.58908259
94RPS6KL10.58755619
95RPS6KC10.58755619
96FGFR10.56918043
97GRK70.56283811
98MAPK80.56201726
99CAMK10.54277148
100MARK10.53846955
101DAPK30.53337484
102TGFBR20.52637111
103TAOK20.52565206
104SGK4940.52368607
105SGK2230.52368607
106WNK10.52334835
107CAMK2A0.49464346
108PRKCE0.49209766
109MAPK30.48761996
110MAP2K60.47156132
111PRKAA10.46647675
112MST1R0.45980398
113NUAK10.45935779
114MAPKAPK30.45170497
115CSF1R0.44468460
116SIK30.43917442
117AKT20.42611640
118PRKCZ0.41925965
119CAMK2G0.41122214
120PRKG20.41087287
121MAPKAPK20.40648412
122SMG10.40493131
123CAMK2B0.40475431
124SGK30.40329551
125FGFR30.39551199
126RPS6KA60.39476871
127ADRBK10.38520022
128MAP3K20.37773742
129MAPK10.37413312
130STK390.37312559
131CSNK1A10.37093982
132NTRK10.36958483
133SGK20.33811151
134RPS6KA10.32779905
135CAMK1G0.32697614
136PRKCH0.32491057
137RPS6KA20.31282367
138GRK10.28839238
139PRKACB0.28226145
140CAMK1D0.26871649
141PTK60.26568802
142PRKACG0.26275504
143PKN10.25838742
144MAP2K10.24851494
145SIK20.24417077
146PDPK10.24187388
147PRKACA0.23765143

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.86347631
2ECM-receptor interaction_Homo sapiens_hsa045123.83687471
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.73892296
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.63789460
5Dilated cardiomyopathy_Homo sapiens_hsa054143.62943486
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.84925763
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.56929568
8Oxidative phosphorylation_Homo sapiens_hsa001902.52144064
9Parkinsons disease_Homo sapiens_hsa050122.30722203
10Protein digestion and absorption_Homo sapiens_hsa049742.10949484
11Propanoate metabolism_Homo sapiens_hsa006402.08556012
12Focal adhesion_Homo sapiens_hsa045102.07004797
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97449061
14Basal cell carcinoma_Homo sapiens_hsa052171.90100500
15Huntingtons disease_Homo sapiens_hsa050161.83178340
16Other glycan degradation_Homo sapiens_hsa005111.77418952
17Hedgehog signaling pathway_Homo sapiens_hsa043401.76255614
18Alzheimers disease_Homo sapiens_hsa050101.74443553
19Adherens junction_Homo sapiens_hsa045201.69395012
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65875197
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58866024
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55237211
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54809381
24ABC transporters_Homo sapiens_hsa020101.42950888
25TGF-beta signaling pathway_Homo sapiens_hsa043501.37561273
26mTOR signaling pathway_Homo sapiens_hsa041501.37195554
27Choline metabolism in cancer_Homo sapiens_hsa052311.35149143
28Viral myocarditis_Homo sapiens_hsa054161.34543793
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34409515
30Carbon metabolism_Homo sapiens_hsa012001.32737469
31Sphingolipid metabolism_Homo sapiens_hsa006001.30439979
32Hippo signaling pathway_Homo sapiens_hsa043901.30274763
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28981545
34Glucagon signaling pathway_Homo sapiens_hsa049221.26836073
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.26526763
36Amoebiasis_Homo sapiens_hsa051461.24970378
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.22952669
38Endometrial cancer_Homo sapiens_hsa052131.22939665
39Lysine degradation_Homo sapiens_hsa003101.20374091
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17905696
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15267729
42Proteoglycans in cancer_Homo sapiens_hsa052051.14422757
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.13990076
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.13329201
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11156853
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09872296
47Small cell lung cancer_Homo sapiens_hsa052221.09472054
48Tight junction_Homo sapiens_hsa045301.09124247
49Wnt signaling pathway_Homo sapiens_hsa043101.06576161
50Pyruvate metabolism_Homo sapiens_hsa006201.05813305
51PPAR signaling pathway_Homo sapiens_hsa033201.05659373
52ErbB signaling pathway_Homo sapiens_hsa040121.04929382
53Fatty acid degradation_Homo sapiens_hsa000710.97966662
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97931408
55Thyroid cancer_Homo sapiens_hsa052160.97509847
56VEGF signaling pathway_Homo sapiens_hsa043700.96855987
57Nitrogen metabolism_Homo sapiens_hsa009100.96472861
58Acute myeloid leukemia_Homo sapiens_hsa052210.94643137
59Inositol phosphate metabolism_Homo sapiens_hsa005620.93456111
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92714720
61Insulin resistance_Homo sapiens_hsa049310.90485109
62Renin secretion_Homo sapiens_hsa049240.89915424
63Bile secretion_Homo sapiens_hsa049760.86590872
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85132498
65Prolactin signaling pathway_Homo sapiens_hsa049170.84821553
66Sulfur metabolism_Homo sapiens_hsa009200.84685895
67HIF-1 signaling pathway_Homo sapiens_hsa040660.83881938
68Circadian rhythm_Homo sapiens_hsa047100.82047598
69Glycerolipid metabolism_Homo sapiens_hsa005610.79671295
70Pathways in cancer_Homo sapiens_hsa052000.78508406
71Lysosome_Homo sapiens_hsa041420.77714444
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76751838
73Melanogenesis_Homo sapiens_hsa049160.76122489
74Glioma_Homo sapiens_hsa052140.75789076
75Notch signaling pathway_Homo sapiens_hsa043300.75083702
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74356898
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74164844
78Calcium signaling pathway_Homo sapiens_hsa040200.71465420
79GnRH signaling pathway_Homo sapiens_hsa049120.70545554
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70328043
81AMPK signaling pathway_Homo sapiens_hsa041520.69571251
82Vitamin digestion and absorption_Homo sapiens_hsa049770.69072716
83Arginine and proline metabolism_Homo sapiens_hsa003300.69026055
84cAMP signaling pathway_Homo sapiens_hsa040240.68389986
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66044346
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65236762
87Fatty acid metabolism_Homo sapiens_hsa012120.65197282
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63957036
89Hepatitis C_Homo sapiens_hsa051600.62333985
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.62264403
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.62052008
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60511203
93Histidine metabolism_Homo sapiens_hsa003400.60282065
94Linoleic acid metabolism_Homo sapiens_hsa005910.59492687
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58881105
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.58361744
97Platelet activation_Homo sapiens_hsa046110.58194243
98Insulin signaling pathway_Homo sapiens_hsa049100.57755849
99Oxytocin signaling pathway_Homo sapiens_hsa049210.57710082
100Glutamatergic synapse_Homo sapiens_hsa047240.57365286
101Fat digestion and absorption_Homo sapiens_hsa049750.57091591
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56523977
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.56405176
104Taste transduction_Homo sapiens_hsa047420.56096894
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55955245
106Estrogen signaling pathway_Homo sapiens_hsa049150.55673857
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54827805
108Prostate cancer_Homo sapiens_hsa052150.54612438
109Pancreatic secretion_Homo sapiens_hsa049720.53727217
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52160383
111Salivary secretion_Homo sapiens_hsa049700.51756668
112Endocytosis_Homo sapiens_hsa041440.51512996
113Thyroid hormone synthesis_Homo sapiens_hsa049180.51447148
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51309950
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51149816
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51130959
117Gap junction_Homo sapiens_hsa045400.50796736
118Chronic myeloid leukemia_Homo sapiens_hsa052200.50448022
119Ovarian steroidogenesis_Homo sapiens_hsa049130.49764716
120Ras signaling pathway_Homo sapiens_hsa040140.47426713
121Renal cell carcinoma_Homo sapiens_hsa052110.46949809
122Melanoma_Homo sapiens_hsa052180.44111915
123Vibrio cholerae infection_Homo sapiens_hsa051100.43304665
124Fructose and mannose metabolism_Homo sapiens_hsa000510.42913638
125MicroRNAs in cancer_Homo sapiens_hsa052060.42795114
126Toxoplasmosis_Homo sapiens_hsa051450.42219490
127Insulin secretion_Homo sapiens_hsa049110.41143074
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40521468
129Starch and sucrose metabolism_Homo sapiens_hsa005000.40237700
130Galactose metabolism_Homo sapiens_hsa000520.39339505
131Rap1 signaling pathway_Homo sapiens_hsa040150.38597265
132Axon guidance_Homo sapiens_hsa043600.37740628
133Type II diabetes mellitus_Homo sapiens_hsa049300.36580575
134Amphetamine addiction_Homo sapiens_hsa050310.35637920
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34693038
136Dorso-ventral axis formation_Homo sapiens_hsa043200.33590183
137Gastric acid secretion_Homo sapiens_hsa049710.30832065
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27562496
139Circadian entrainment_Homo sapiens_hsa047130.27425259
140HTLV-I infection_Homo sapiens_hsa051660.26340754
141Selenocompound metabolism_Homo sapiens_hsa004500.25848538
142Bladder cancer_Homo sapiens_hsa052190.23721456

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