SCUBE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)9.08590450
2lateral sprouting from an epithelium (GO:0060601)8.79800200
3mesenchymal-epithelial cell signaling (GO:0060638)7.81383969
4prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060527.68523005
5regulation of branching involved in salivary gland morphogenesis (GO:0060693)6.30588864
6craniofacial suture morphogenesis (GO:0097094)6.29325491
7bone trabecula formation (GO:0060346)6.29175911
8cell proliferation involved in metanephros development (GO:0072203)5.83740028
9branching involved in labyrinthine layer morphogenesis (GO:0060670)5.78563320
10planar cell polarity pathway involved in neural tube closure (GO:0090179)5.62600975
11branching involved in prostate gland morphogenesis (GO:0060442)5.61106826
12chondrocyte proliferation (GO:0035988)5.60722714
13cell proliferation involved in kidney development (GO:0072111)5.38691818
14regulation of non-canonical Wnt signaling pathway (GO:2000050)5.34796705
15regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.31473990
16arginine catabolic process (GO:0006527)5.30778766
17mesenchymal cell proliferation (GO:0010463)5.26351543
18branching involved in salivary gland morphogenesis (GO:0060445)5.23696121
19radial glial cell differentiation (GO:0060019)5.20396933
20regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.92216006
21cranial suture morphogenesis (GO:0060363)4.80312464
22negative regulation of axon guidance (GO:1902668)4.63708803
23somite development (GO:0061053)4.58156794
24negative regulation of osteoblast proliferation (GO:0033689)4.56741996
25convergent extension (GO:0060026)4.48476961
26negative regulation of axon extension involved in axon guidance (GO:0048843)4.41425198
27NLS-bearing protein import into nucleus (GO:0006607)4.40026148
28keratinocyte proliferation (GO:0043616)4.33999035
29prostate gland epithelium morphogenesis (GO:0060740)4.28856431
30collagen fibril organization (GO:0030199)4.22663310
31sequestering of extracellular ligand from receptor (GO:0035581)4.22592048
32negative regulation of fibroblast apoptotic process (GO:2000270)4.14559899
33lung-associated mesenchyme development (GO:0060484)4.12827856
34positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)4.11984494
35otic vesicle formation (GO:0030916)4.10929909
36cellular response to interferon-alpha (GO:0035457)4.07195267
37dorsal/ventral axis specification (GO:0009950)4.05331359
38proximal/distal pattern formation (GO:0009954)4.04738806
39fibroblast migration (GO:0010761)4.02886688
40protein retention in ER lumen (GO:0006621)4.00085663
41renal system development (GO:0072001)3.99841068
42cellular response to vitamin D (GO:0071305)3.97845089
43limb bud formation (GO:0060174)3.96137315
44hindlimb morphogenesis (GO:0035137)3.93930771
45substrate adhesion-dependent cell spreading (GO:0034446)3.93190337
46paraxial mesoderm development (GO:0048339)3.91467354
47axis elongation (GO:0003401)3.88238640
48cellular response to cholesterol (GO:0071397)3.86165923
49positive regulation of protein autophosphorylation (GO:0031954)3.80372645
50ovulation cycle (GO:0042698)3.75404796
51Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.74646119
52digestive tract morphogenesis (GO:0048546)3.73407465
53vagina development (GO:0060068)3.72017777
54negative regulation of catenin import into nucleus (GO:0035414)3.68253762
55negative regulation of smoothened signaling pathway (GO:0045879)3.67216811
56artery smooth muscle contraction (GO:0014824)3.65491169
57regulation of establishment of planar polarity (GO:0090175)3.63871208
58regulation of axon guidance (GO:1902667)3.61310891
59axon extension involved in axon guidance (GO:0048846)3.60819921
60neuron projection extension involved in neuron projection guidance (GO:1902284)3.60819921
61mesenchymal cell differentiation (GO:0048762)3.59882556
62branch elongation of an epithelium (GO:0060602)3.58909717
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54214727
64regulation of keratinocyte proliferation (GO:0010837)3.50870193
65regulation of smoothened signaling pathway (GO:0008589)3.49815336
66neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.48466603
67hair follicle morphogenesis (GO:0031069)3.48334552
68female genitalia development (GO:0030540)3.47280508
69embryonic hindlimb morphogenesis (GO:0035116)3.46577825
70organ induction (GO:0001759)3.43158861
71regulation of axon extension involved in axon guidance (GO:0048841)3.34287674
72regulation of integrin-mediated signaling pathway (GO:2001044)3.33262714
73glial cell migration (GO:0008347)3.32865832
74protein localization to cell surface (GO:0034394)3.31418527
75morphogenesis of an epithelial fold (GO:0060571)3.31257015
76neuronal ion channel clustering (GO:0045161)3.31152498
77cellular response to prostaglandin stimulus (GO:0071379)3.30695905
78response to pheromone (GO:0019236)3.30589350
79non-canonical Wnt signaling pathway (GO:0035567)3.23383427
80regulation of morphogenesis of a branching structure (GO:0060688)3.23371521
81tonic smooth muscle contraction (GO:0014820)3.22819896
82negative regulation of JUN kinase activity (GO:0043508)3.20142994
83negative regulation of chondrocyte differentiation (GO:0032331)3.18929316
84organ growth (GO:0035265)3.18859401
85negative regulation of gluconeogenesis (GO:0045721)3.12442872
86embryonic limb morphogenesis (GO:0030326)3.11224480
87embryonic appendage morphogenesis (GO:0035113)3.11224480
88organ formation (GO:0048645)3.07819976
89somatic stem cell division (GO:0048103)3.07721737
90positive regulation of natural killer cell differentiation (GO:0032825)3.07077711
91type B pancreatic cell proliferation (GO:0044342)3.06305064
92mesodermal cell differentiation (GO:0048333)3.01145078
93dermatan sulfate biosynthetic process (GO:0030208)3.01027694
94embryonic forelimb morphogenesis (GO:0035115)3.00911794
95genitalia morphogenesis (GO:0035112)2.99880034
96hematopoietic stem cell differentiation (GO:0060218)2.98938772
97appendage morphogenesis (GO:0035107)2.98057393
98limb morphogenesis (GO:0035108)2.98057393
99regulation of osteoblast proliferation (GO:0033688)2.97457693
100outer ear morphogenesis (GO:0042473)2.96833524
101female gonad development (GO:0008585)2.96676162
102negative chemotaxis (GO:0050919)2.95719191
103mesonephros development (GO:0001823)2.94980946
104heart morphogenesis (GO:0003007)2.93557712
105cellular response to sterol (GO:0036315)2.92288594
106positive regulation of fibroblast migration (GO:0010763)2.91814087
107histone H2A acetylation (GO:0043968)2.90280964
108regulation of developmental pigmentation (GO:0048070)2.89536903
109positive regulation of actin filament depolymerization (GO:0030836)2.88855277
110anatomical structure regression (GO:0060033)2.88049781
111regulation of chondrocyte differentiation (GO:0032330)2.87831235
112anterograde synaptic vesicle transport (GO:0048490)2.87012064
113negative regulation of multicellular organism growth (GO:0040015)2.86031161
114retinal ganglion cell axon guidance (GO:0031290)2.85289122
115epithelial tube branching involved in lung morphogenesis (GO:0060441)2.84908875
116branching involved in ureteric bud morphogenesis (GO:0001658)2.84773882
117tube closure (GO:0060606)2.84629534
118negative regulation of osteoblast differentiation (GO:0045668)2.83674017
119heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.83182631
120smooth muscle tissue development (GO:0048745)2.83065189
121positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.82632369
122positive regulation of cell cycle G2/M phase transition (GO:1902751)2.82632369
123positive regulation of smoothened signaling pathway (GO:0045880)2.81820092
124chondrocyte development (GO:0002063)2.81143974
125regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80031664
126intraciliary transport (GO:0042073)2.79528553
127regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.79372821
128endocrine process (GO:0050886)2.79372821
129regulation of systemic arterial blood pressure by hormone (GO:0001990)2.79372821
130negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.79148075
131cell differentiation involved in kidney development (GO:0061005)2.77964803
132regulation of cartilage development (GO:0061035)2.76699726
133arginine metabolic process (GO:0006525)2.75830069
134lens fiber cell development (GO:0070307)2.73277409
135negative regulation of stem cell proliferation (GO:2000647)2.72676474
136branched-chain amino acid catabolic process (GO:0009083)2.71218615
137cullin deneddylation (GO:0010388)2.65097980
138lymphangiogenesis (GO:0001946)2.61569935
139regulation of organ formation (GO:0003156)2.59727439
140generation of neurons (GO:0048699)2.58851698
141ventricular cardiac muscle cell development (GO:0055015)2.57149945
142metanephric mesenchyme development (GO:0072075)2.54604605
143cell migration involved in heart development (GO:0060973)2.52703719
144kidney mesenchyme development (GO:0072074)2.49783408
145mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.48764592
146cilium morphogenesis (GO:0060271)2.48498006
147actin filament depolymerization (GO:0030042)2.47342192
148cell aggregation (GO:0098743)2.47152492
149cartilage condensation (GO:0001502)2.47152492
150myoblast migration (GO:0051451)2.44451012
151epithelial cilium movement (GO:0003351)2.43476559
152regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.42731352
153embryonic cranial skeleton morphogenesis (GO:0048701)2.42635103
154regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.40711053
155substrate-dependent cell migration (GO:0006929)2.40239633
156peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.39376988
157extracellular negative regulation of signal transduction (GO:1900116)2.38556372
158extracellular regulation of signal transduction (GO:1900115)2.38556372
159smoothened signaling pathway (GO:0007224)2.37934598
160cartilage morphogenesis (GO:0060536)2.37360002
161negative regulation of embryonic development (GO:0045992)2.37031155
162cardiac muscle cell development (GO:0055013)2.36633881
163face morphogenesis (GO:0060325)2.36157454
164regulation of protein autophosphorylation (GO:0031952)2.35280236
165olfactory bulb development (GO:0021772)2.33436913
166cornea development in camera-type eye (GO:0061303)2.32912423
167protein deneddylation (GO:0000338)2.32555328
168axon extension (GO:0048675)2.32511928
169protein polyglutamylation (GO:0018095)2.31181801
170dopaminergic neuron differentiation (GO:0071542)2.28741830
171palate development (GO:0060021)2.27748636
172anterior/posterior axis specification, embryo (GO:0008595)2.25218943
173head development (GO:0060322)2.24430847
174regulation of timing of cell differentiation (GO:0048505)2.23781879
175myelin assembly (GO:0032288)2.23459604
176apoptotic cell clearance (GO:0043277)2.22811535
177embryonic camera-type eye development (GO:0031076)2.21610723
178appendage development (GO:0048736)2.20645518
179limb development (GO:0060173)2.20645518
180positive regulation of interleukin-8 secretion (GO:2000484)2.19696415
181forelimb morphogenesis (GO:0035136)2.18961539
182short-term memory (GO:0007614)2.18398385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.38930967
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.00461209
3TP63_19390658_ChIP-ChIP_HaCaT_Human2.97324362
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.96038087
5ZNF274_21170338_ChIP-Seq_K562_Hela2.68457576
6EZH2_22144423_ChIP-Seq_EOC_Human2.61197113
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.58794918
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.45746064
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.40557755
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.30154617
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.29225689
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.29225689
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.29225689
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26160957
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.22707100
16EWS_26573619_Chip-Seq_HEK293_Human2.21114040
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.20892291
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17876179
19BRD4_25478319_ChIP-Seq_HGPS_Human2.14174707
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.11148385
21AR_21572438_ChIP-Seq_LNCaP_Human2.09424866
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09136720
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.07741072
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07627430
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04255047
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.03726855
27GBX2_23144817_ChIP-Seq_PC3_Human2.02154299
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01814398
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01814398
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97377385
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93207334
32TBX3_20139965_ChIP-Seq_ESCs_Mouse1.92576703
33TBX3_20139965_ChIP-Seq_MESCs_Mouse1.91218763
34* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.89906324
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88689394
36* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.87171718
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86097303
38TAF15_26573619_Chip-Seq_HEK293_Human1.85082111
39CJUN_26792858_Chip-Seq_BT549_Human1.81376790
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81243167
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80039529
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.79918204
43* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79896711
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.79581297
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78565704
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75354842
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70382012
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.69437587
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.66866220
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.66866220
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65136242
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60108405
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59482695
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58694687
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57283290
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.57176708
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.57129436
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56018810
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53281715
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52707146
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52707146
62* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51796046
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50049388
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49308918
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48963063
66* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48897074
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48815252
68* RING1B_27294783_Chip-Seq_NPCs_Mouse1.46986266
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45999656
70AHR_22903824_ChIP-Seq_MCF-7_Human1.45179324
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.43908494
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40609053
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39358029
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.38411723
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38321042
76ELK1_19687146_ChIP-ChIP_HELA_Human1.37523927
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37150924
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36159582
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36116215
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36111681
81SMAD4_21799915_ChIP-Seq_A2780_Human1.34385803
82ER_23166858_ChIP-Seq_MCF-7_Human1.34248876
83FUS_26573619_Chip-Seq_HEK293_Human1.32136223
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32100190
85IGF1R_20145208_ChIP-Seq_DFB_Human1.31531891
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.31146034
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30997723
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30193609
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30082236
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29193853
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29179030
92AR_25329375_ChIP-Seq_VCAP_Human1.28708538
93DROSHA_22980978_ChIP-Seq_HELA_Human1.28093907
94SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.27815805
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27601043
96EGR1_19374776_ChIP-ChIP_THP-1_Human1.26327770
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.26243816
98P300_19829295_ChIP-Seq_ESCs_Human1.26111328
99* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24544563
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23769182
101RXR_22108803_ChIP-Seq_LS180_Human1.22847445
102* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22627934
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22455599
104TRIM28_21343339_ChIP-Seq_HEK293_Human1.22000518
105* TP53_20018659_ChIP-ChIP_R1E_Mouse1.21823214
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21291278
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20955899
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19604498
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.19456961
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.19281439
111WT1_19549856_ChIP-ChIP_CCG9911_Human1.19167484
112P53_22387025_ChIP-Seq_ESCs_Mouse1.18402286
113* RING1B_27294783_Chip-Seq_ESCs_Mouse1.16880264
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16775327
115TCF4_23295773_ChIP-Seq_U87_Human1.16169665
116VDR_22108803_ChIP-Seq_LS180_Human1.14015162
117* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13899148
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13110989
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12958140
120SOX2_21211035_ChIP-Seq_LN229_Gbm1.12929820
121TP53_16413492_ChIP-PET_HCT116_Human1.12640625
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11909666
123CBP_20019798_ChIP-Seq_JUKART_Human1.10034453
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10034453
125* RUNX2_22187159_ChIP-Seq_PCA_Human1.09817394
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09651704
127EP300_21415370_ChIP-Seq_HL-1_Mouse1.09437506
128TP53_18474530_ChIP-ChIP_U2OS_Human1.09243274
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09191707
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09122765
131RNF2_27304074_Chip-Seq_NSC_Mouse1.07690972
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.07549864
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06462282
134SMAD_19615063_ChIP-ChIP_OVARY_Human1.06103170
135CBX2_27304074_Chip-Seq_ESCs_Mouse1.05750141
136EZH2_27294783_Chip-Seq_ESCs_Mouse1.05535796
137STAT3_23295773_ChIP-Seq_U87_Human1.05247990
138CMYC_18555785_Chip-Seq_ESCs_Mouse1.05179800
139SOX9_26525672_Chip-Seq_HEART_Mouse1.04831323
140JUN_21703547_ChIP-Seq_K562_Human1.04715699
141SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04559099
142KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04241671
143CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04232619
144* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03034041
145TCF4_18268006_ChIP-ChIP_LS174T_Human1.02871779
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01807118
147MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01327815
148AR_19668381_ChIP-Seq_PC3_Human1.00903961
149SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00516179
150OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99546779
151NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99246290
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99165130
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98432854
154STAT3_18555785_Chip-Seq_ESCs_Mouse0.98150240
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97213587
156OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96679350
157EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94117413
158BCAT_22108803_ChIP-Seq_LS180_Human0.93291899
159* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90590925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005187_abnormal_penis_morphology4.23967383
2MP0002938_white_spotting3.96533113
3MP0005503_abnormal_tendon_morphology3.75445417
4MP0000566_synostosis3.64996496
5MP0010030_abnormal_orbit_morphology3.30734049
6MP0003950_abnormal_plasma_membrane3.28097540
7MP0001299_abnormal_eye_distance/3.26618576
8MP0005171_absent_coat_pigmentation3.21216634
9MP0009250_abnormal_appendicular_skeleto2.95311796
10MP0000372_irregular_coat_pigmentation2.93230797
11MP0000537_abnormal_urethra_morphology2.85702353
12MP0004272_abnormal_basement_membrane2.85259771
13MP0005248_abnormal_Harderian_gland2.73983575
14MP0001293_anophthalmia2.70278271
15MP0005275_abnormal_skin_tensile2.67759687
16MP0000428_abnormal_craniofacial_morphol2.64129440
17MP0002282_abnormal_trachea_morphology2.60724803
18MP0006054_spinal_hemorrhage2.40099085
19MP0005623_abnormal_meninges_morphology2.27350761
20MP0004134_abnormal_chest_morphology2.25970324
21MP0001958_emphysema2.22919617
22MP0003942_abnormal_urinary_system2.19849690
23MP0003385_abnormal_body_wall2.15835319
24MP0009053_abnormal_anal_canal2.12013882
25MP0003279_aneurysm2.11613840
26MP0001661_extended_life_span2.02695107
27MP0003937_abnormal_limbs/digits/tail_de1.98981154
28MP0002108_abnormal_muscle_morphology1.88392888
29MP0002116_abnormal_craniofacial_bone1.81064274
30MP0005257_abnormal_intraocular_pressure1.80485186
31MP0003935_abnormal_craniofacial_develop1.74358091
32MP0000579_abnormal_nail_morphology1.66450883
33MP0003755_abnormal_palate_morphology1.64009734
34MP0003122_maternal_imprinting1.61868825
35MP0000516_abnormal_urinary_system1.60672365
36MP0005367_renal/urinary_system_phenotyp1.60672365
37MP0003938_abnormal_ear_development1.57470806
38MP0005508_abnormal_skeleton_morphology1.55289485
39MP0002932_abnormal_joint_morphology1.55120617
40MP0001346_abnormal_lacrimal_gland1.54561011
41MP0003941_abnormal_skin_development1.52680183
42MP0000427_abnormal_hair_cycle1.52501151
43MP0000647_abnormal_sebaceous_gland1.52192029
44MP0004084_abnormal_cardiac_muscle1.51530255
45MP0000462_abnormal_digestive_system1.50249425
46MP0002109_abnormal_limb_morphology1.49170334
47MP0000762_abnormal_tongue_morphology1.46646246
48MP0000432_abnormal_head_morphology1.45862532
49MP0009384_cardiac_valve_regurgitation1.45589660
50MP0000534_abnormal_ureter_morphology1.43710588
51MP0000049_abnormal_middle_ear1.43282225
52MP0002102_abnormal_ear_morphology1.40004507
53MP0000569_abnormal_digit_pigmentation1.38665531
54MP0000538_abnormal_urinary_bladder1.35344898
55MP0005174_abnormal_tail_pigmentation1.34048848
56MP0000163_abnormal_cartilage_morphology1.33899676
57MP0002115_abnormal_skeleton_extremities1.30844085
58MP0000767_abnormal_smooth_muscle1.29826172
59MP0000015_abnormal_ear_pigmentation1.26284935
60MP0002092_abnormal_eye_morphology1.25752217
61MP0002177_abnormal_outer_ear1.24983030
62MP0010307_abnormal_tumor_latency1.24216042
63MP0010368_abnormal_lymphatic_system1.20018009
64MP0004133_heterotaxia1.19917946
65MP0003121_genomic_imprinting1.19207591
66MP0000751_myopathy1.19170938
67MP0002090_abnormal_vision1.18322091
68MP0002089_abnormal_postnatal_growth/wei1.17151660
69MP0005075_abnormal_melanosome_morpholog1.17046839
70MP0003705_abnormal_hypodermis_morpholog1.16315631
71MP0002249_abnormal_larynx_morphology1.16303131
72MP0005084_abnormal_gallbladder_morpholo1.15873844
73MP0003123_paternal_imprinting1.14952655
74MP0010386_abnormal_urinary_bladder1.11640120
75MP0002896_abnormal_bone_mineralization1.11075728
76MP0003115_abnormal_respiratory_system1.08536671
77MP0001485_abnormal_pinna_reflex1.08235662
78MP0002233_abnormal_nose_morphology1.07878838
79MP0002114_abnormal_axial_skeleton1.07069629
80MP0003119_abnormal_digestive_system1.06474362
81MP0004197_abnormal_fetal_growth/weight/1.04730743
82MP0001340_abnormal_eyelid_morphology1.03278740
83MP0002098_abnormal_vibrissa_morphology1.03175309
84MP0005076_abnormal_cell_differentiation1.03134840
85MP0003861_abnormal_nervous_system1.00637185
86MP0002697_abnormal_eye_size1.00589530
87MP0003252_abnormal_bile_duct1.00388904
88MP0002085_abnormal_embryonic_tissue0.99036912
89MP0001177_atelectasis0.98338923
90MP0000778_abnormal_nervous_system0.97603754
91MP0000733_abnormal_muscle_development0.97362279
92MP0002113_abnormal_skeleton_development0.97291958
93MP0003880_abnormal_central_pattern0.96888209
94MP0002295_abnormal_pulmonary_circulatio0.93997828
95MP0005551_abnormal_eye_electrophysiolog0.93376036
96MP0003283_abnormal_digestive_organ0.93325908
97MP0001529_abnormal_vocalization0.93188708
98MP0008775_abnormal_heart_ventricle0.91986989
99MP0005408_hypopigmentation0.91605213
100MP0002111_abnormal_tail_morphology0.89380963
101MP0008438_abnormal_cutaneous_collagen0.88981317
102MP0002234_abnormal_pharynx_morphology0.88487634
103MP0004885_abnormal_endolymph0.88174614
104MP0002084_abnormal_developmental_patter0.87318883
105MP0005253_abnormal_eye_physiology0.87100164
106MP0002928_abnormal_bile_duct0.86281432
107MP0009703_decreased_birth_body0.84951030
108MP0003936_abnormal_reproductive_system0.84072924
109MP0005197_abnormal_uvea_morphology0.83828178
110MP0000639_abnormal_adrenal_gland0.83780260
111MP0009780_abnormal_chondrocyte_physiolo0.82631423
112MP0005023_abnormal_wound_healing0.82345581
113MP0005595_abnormal_vascular_smooth0.81920089
114MP0001879_abnormal_lymphatic_vessel0.80351543
115MP0002160_abnormal_reproductive_system0.79540602
116MP0005220_abnormal_exocrine_pancreas0.78954045
117MP0000371_diluted_coat_color0.78841113
118MP0003011_delayed_dark_adaptation0.78610494
119MP0002751_abnormal_autonomic_nervous0.78442176
120MP0001849_ear_inflammation0.77474508
121MP0002925_abnormal_cardiovascular_devel0.76875197
122MP0006072_abnormal_retinal_apoptosis0.76560816
123MP0001243_abnormal_dermal_layer0.76305776
124MP0001119_abnormal_female_reproductive0.76040811
125MP0003943_abnormal_hepatobiliary_system0.75967260
126MP0006292_abnormal_olfactory_placode0.75869721
127MP0003890_abnormal_embryonic-extraembry0.75854672
128MP0001286_abnormal_eye_development0.74651968
129MP0005391_vision/eye_phenotype0.73923739
130MP0000026_abnormal_inner_ear0.73351499
131MP0005377_hearing/vestibular/ear_phenot0.73013392
132MP0003878_abnormal_ear_physiology0.73013392
133MP0002081_perinatal_lethality0.69929219
134MP0005195_abnormal_posterior_eye0.69621646
135MP0000383_abnormal_hair_follicle0.69000698
136MP0002088_abnormal_embryonic_growth/wei0.68711250
137MP0001175_abnormal_lung_morphology0.68412497
138MP0002095_abnormal_skin_pigmentation0.67378263
139MP0005193_abnormal_anterior_eye0.67274707
140MP0002168_other_aberrant_phenotype0.66443386
141MP0005409_darkened_coat_color0.66188703
142MP0000631_abnormal_neuroendocrine_gland0.65864778
143MP0000749_muscle_degeneration0.65608567
144MP0003136_yellow_coat_color0.65037130

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the parietal bone (HP:0002696)6.64687559
2Midline defect of the nose (HP:0004122)6.17032870
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)6.10125822
4Short 4th metacarpal (HP:0010044)6.10125822
5Trigonocephaly (HP:0000243)5.17837172
6Abnormality of the 4th metacarpal (HP:0010012)4.40666112
7Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.04143581
8Abnormality of the diencephalon (HP:0010662)3.94195540
9Nasolacrimal duct obstruction (HP:0000579)3.94042377
10Vitreoretinal degeneration (HP:0000655)3.88071684
11Toxemia of pregnancy (HP:0100603)3.87695998
12Cervical subluxation (HP:0003308)3.76784944
13Neoplasm of the heart (HP:0100544)3.76248803
14Abnormality of the nasal septum (HP:0000419)3.74789877
15Abnormality of the distal phalanx of the thumb (HP:0009617)3.67698620
16Shallow orbits (HP:0000586)3.65156148
17Anteriorly placed anus (HP:0001545)3.54568084
18Broad metatarsal (HP:0001783)3.51091962
19Premature rupture of membranes (HP:0001788)3.42015521
20Broad face (HP:0000283)3.36004216
21Abnormality of the lacrimal duct (HP:0011481)3.32560391
22Soft skin (HP:0000977)3.27524588
23Aortic dissection (HP:0002647)3.26532350
24Abnormality of the nasolacrimal system (HP:0000614)3.20712454
25Abnormal number of incisors (HP:0011064)3.20041701
26Alacrima (HP:0000522)3.13966958
27Exostoses (HP:0100777)3.11430338
28Short phalanx of the thumb (HP:0009660)3.10214790
29Abnormality of the labia minora (HP:0012880)3.03676138
30Disproportionate short-trunk short stature (HP:0003521)3.01752747
31Abnormality of midbrain morphology (HP:0002418)2.97959416
32Molar tooth sign on MRI (HP:0002419)2.97959416
33Large earlobe (HP:0009748)2.93991675
34Aplasia of the phalanges of the hand (HP:0009802)2.93827160
35Aplasia involving bones of the extremities (HP:0009825)2.93827160
36Aplasia involving bones of the upper limbs (HP:0009823)2.93827160
37Supernumerary ribs (HP:0005815)2.89544626
38Hypoplasia of the odontoid process (HP:0003311)2.88740856
39Bifid tongue (HP:0010297)2.88593294
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.86847151
41Abnormality of the incisor (HP:0000676)2.86008708
42Coronal craniosynostosis (HP:0004440)2.85952276
43Neoplasm of the oral cavity (HP:0100649)2.84300404
44Flat capital femoral epiphysis (HP:0003370)2.78736281
45Partial duplication of the phalanx of hand (HP:0009999)2.75983236
46Hypoplastic ischia (HP:0003175)2.74210581
47Pancreatic fibrosis (HP:0100732)2.72426899
48Depressed nasal tip (HP:0000437)2.71937158
49Delayed gross motor development (HP:0002194)2.70332538
50Aplasia cutis congenita (HP:0001057)2.67734536
51Turricephaly (HP:0000262)2.66583300
52Medulloblastoma (HP:0002885)2.63280529
53Partial duplication of thumb phalanx (HP:0009944)2.63013368
54Flared iliac wings (HP:0002869)2.62190021
55Limited hip movement (HP:0008800)2.62130346
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.60465505
57Nephronophthisis (HP:0000090)2.59589404
58Bilateral microphthalmos (HP:0007633)2.59504050
59Humeroradial synostosis (HP:0003041)2.58481823
60Synostosis involving the elbow (HP:0003938)2.58481823
61Supernumerary bones of the axial skeleton (HP:0009144)2.58221110
62Neonatal short-limb short stature (HP:0008921)2.57400417
63Down-sloping shoulders (HP:0200021)2.55943828
64Abnormality of the proximal phalanges of the hand (HP:0009834)2.55754843
65Concave nail (HP:0001598)2.55540927
66True hermaphroditism (HP:0010459)2.55121127
67Short tibia (HP:0005736)2.55053840
68Follicular hyperkeratosis (HP:0007502)2.53731017
69Abnormality of incisor morphology (HP:0011063)2.52808535
70Broad toe (HP:0001837)2.51937793
71Decreased lacrimation (HP:0000633)2.51037196
72Rectal fistula (HP:0100590)2.50580203
73Rectovaginal fistula (HP:0000143)2.50580203
74Bell-shaped thorax (HP:0001591)2.49396471
75Aortic aneurysm (HP:0004942)2.47553885
76Microglossia (HP:0000171)2.46780798
77Broad hallux (HP:0010055)2.45110728
78Barrel-shaped chest (HP:0001552)2.45048054
79Protrusio acetabuli (HP:0003179)2.44050867
80Mesomelia (HP:0003027)2.39933054
81Abnormality of the ischium (HP:0003174)2.39755359
82Intestinal fistula (HP:0100819)2.39232236
83Abnormality of dentin (HP:0010299)2.36462214
84Anophthalmia (HP:0000528)2.36303719
85Cerebellar dysplasia (HP:0007033)2.35610442
86Vascular tortuosity (HP:0004948)2.34288427
87Pancreatic cysts (HP:0001737)2.33590565
88Hip contracture (HP:0003273)2.33107649
89Sparse lateral eyebrow (HP:0005338)2.32527661
90Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.31974612
91Short 1st metacarpal (HP:0010034)2.31974612
92Broad thumb (HP:0011304)2.31438300
93Narrow palate (HP:0000189)2.30346139
94Increased corneal curvature (HP:0100692)2.28098909
95Keratoconus (HP:0000563)2.28098909
96Albinism (HP:0001022)2.27913263
97Aqueductal stenosis (HP:0002410)2.26661707
98Fibular hypoplasia (HP:0003038)2.25000048
99Bronchomalacia (HP:0002780)2.24685243
100Hypoplastic labia majora (HP:0000059)2.24137775
101Small hand (HP:0200055)2.21556262
102Abnormality of the odontoid process (HP:0003310)2.20687131
103Spondylolisthesis (HP:0003302)2.20407963
104Arterial tortuosity (HP:0005116)2.20043572
105Abnormality of carpal bone ossification (HP:0006257)2.19081980
106Abnormality of the middle phalanges of the hand (HP:0009833)2.16787451
107Hypoplastic pelvis (HP:0008839)2.16607364
108Aplasia/Hypoplasia of the tongue (HP:0010295)2.16152234
109Wide anterior fontanel (HP:0000260)2.16068091
110Abnormal ossification of hand bones (HP:0005921)2.14203311
111Hip dysplasia (HP:0001385)2.12585745
112Abnormality of the middle phalanges of the toes (HP:0010183)2.12325412
113Glioma (HP:0009733)2.11965669
114Abnormal hand bone ossification (HP:0010660)2.11892584
115Abnormality of the renal medulla (HP:0100957)2.11606993
116Vaginal fistula (HP:0004320)2.10605108
117Chorioretinal atrophy (HP:0000533)2.07390624
118Increased number of teeth (HP:0011069)2.06460331
119White forelock (HP:0002211)2.06346949
120Type II lissencephaly (HP:0007260)2.02568512
121Hemivertebrae (HP:0002937)2.00829762
122Hypoplasia of the iris (HP:0007676)2.00769385
123Abnormality of the labia majora (HP:0012881)2.00102012
124Hypoplastic iliac wings (HP:0002866)1.99958474
125Broad phalanx (HP:0006009)1.99544021
126Supernumerary spleens (HP:0009799)1.97167441
127Aortic regurgitation (HP:0001659)1.97045145
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96373909
129Abnormality of the antihelix (HP:0009738)1.96046142
130Hypoplasia of the maxilla (HP:0000327)1.95532574
131Abnormality of the 1st metacarpal (HP:0010009)1.94342035
132Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94213019
133Acute lymphatic leukemia (HP:0006721)1.93639479
134Broad phalanges of the hand (HP:0009768)1.93571208
135Vaginal atresia (HP:0000148)1.93075139
136Anencephaly (HP:0002323)1.92436431
137Genital tract atresia (HP:0001827)1.91891627
138Abnormality of the wing of the ilium (HP:0011867)1.91530304
139Broad finger (HP:0001500)1.90980160
140Broad long bones (HP:0005622)1.90476868
141Genu recurvatum (HP:0002816)1.89903199
142Neoplasm of striated muscle (HP:0009728)1.89163088
143Anal stenosis (HP:0002025)1.88244081
144Deformed sella turcica (HP:0002681)1.87845116
145Preaxial foot polydactyly (HP:0001841)1.87727682
146Infantile muscular hypotonia (HP:0008947)1.85886933
147Short metatarsal (HP:0010743)1.85477264
148Milia (HP:0001056)1.85151908
149Short middle phalanx of finger (HP:0005819)1.84988606
150Omphalocele (HP:0001539)1.83784530
151Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.83702486
152Postaxial hand polydactyly (HP:0001162)1.83602331
153Long clavicles (HP:0000890)1.83342296
154Optic nerve hypoplasia (HP:0000609)1.82934809
155Occipital encephalocele (HP:0002085)1.82358956
156Aortic valve stenosis (HP:0001650)1.82250336
157Recurrent corneal erosions (HP:0000495)1.79423531
158Medial flaring of the eyebrow (HP:0010747)1.79345769
159Micromelia (HP:0002983)1.78565014
160Pulmonary artery stenosis (HP:0004415)1.77854619
161Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.77677252
162Mixed hearing impairment (HP:0000410)1.76721395
163Aplasia/Hypoplasia of the fibula (HP:0006492)1.73952503
164Abnormality of the 2nd finger (HP:0004100)1.71716594
165Cystic liver disease (HP:0006706)1.70603236
166Abnormality of the phalanges of the hallux (HP:0010057)1.67654581
167Renal duplication (HP:0000075)1.67017185
168Morphological abnormality of the middle ear (HP:0008609)1.66692523
169Abnormality of the acetabulum (HP:0003170)1.64938572
170Abnormality of the anterior chamber (HP:0000593)1.62523409
171Chronic hepatic failure (HP:0100626)1.62308020
172Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62263385
173Synostosis of carpal bones (HP:0005048)1.62009982
174Short 5th finger (HP:0009237)1.61074373
175Postaxial foot polydactyly (HP:0001830)1.60510958
176Tubular atrophy (HP:0000092)1.59579253
177Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.59456927
178Short foot (HP:0001773)1.59220456
179Bladder diverticulum (HP:0000015)1.58325972
180Arthropathy (HP:0003040)1.58055418
181Abnormality of the fibula (HP:0002991)1.57982104
182Knee flexion contracture (HP:0006380)1.56945844
183Hyperventilation (HP:0002883)1.56387184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR26.33881634
2LATS15.28140722
3DDR24.98192689
4FRK3.57692514
5LIMK13.44623983
6CDK123.03127501
7FGFR12.85091868
8PDGFRA2.53672597
9SIK12.51108819
10TRIM282.46284085
11PAK32.26375462
12PLK22.22067439
13TNIK2.08860153
14MYLK2.06445742
15BMX2.06390769
16CAMK1G1.99317275
17BRD41.99317155
18BCR1.96641170
19ADRBK21.92068654
20BMPR1B1.91142851
21ACVR1B1.85438560
22EPHA41.79390467
23LATS21.79375245
24CAMK1D1.76892853
25NEK91.74555006
26BRSK21.73566692
27MAP3K121.67891132
28WEE11.57315027
29EPHB21.51078303
30NLK1.49590488
31STK391.49106529
32SIK21.47431683
33PDGFRB1.45371161
34STK31.45110721
35NUAK11.43256252
36WNK31.42536869
37PLK31.39444246
38ICK1.36443821
39PIK3CA1.31750600
40MAP4K21.31516951
41TESK11.28783973
42EPHA31.26925129
43MTOR1.20830612
44PNCK1.17432056
45PRKD31.16418185
46RIPK11.15856064
47GRK71.15010671
48CSNK1A1L1.09516180
49MAPKAPK51.06867651
50FER1.04709621
51TGFBR21.02910437
52MARK21.02833300
53VRK21.02653266
54AKT31.02224866
55CAMK40.95089365
56WNK40.94789776
57GRK10.92128307
58CASK0.92126255
59NTRK30.90193978
60CDC70.90049813
61PIK3CG0.89611740
62DMPK0.88857521
63TYRO30.85100806
64WNK10.84439007
65DYRK20.81298955
66CSNK1G20.80799243
67CHEK20.80221309
68TTN0.78385169
69FLT30.76097557
70BRSK10.75900884
71EIF2AK30.75758821
72ILK0.75617470
73KSR10.74911736
74MUSK0.74561526
75ADRBK10.74242257
76CSNK1G30.74091490
77RET0.74019295
78CDC42BPA0.72737062
79NTRK20.72344107
80MARK10.71357847
81SGK30.71268921
82ROCK20.71179379
83PLK40.70976095
84OXSR10.70598289
85CDK70.70218578
86MAP3K70.69067274
87PTK20.66662034
88CDK60.66350491
89CHUK0.65791145
90SIK30.63718756
91CLK10.60305731
92MAP3K100.57595743
93CDK90.57328546
94MKNK20.56934435
95KIT0.56596712
96TGFBR10.56385731
97PAK20.56297497
98PKN10.55654782
99MKNK10.55533436
100TAOK20.55298517
101ALK0.54650705
102ERBB30.53631196
103TSSK60.51402160
104SGK20.51391588
105MAPK100.51371165
106CAMK2D0.51073358
107MAPK10.50736801
108CDK40.50514351
109PTK2B0.50286837
110STK38L0.49738050
111INSRR0.49435177
112FGFR30.49143969
113MAPK80.48968324
114GSK3A0.48380960
115ATM0.48275435
116CHEK10.47229306
117PRKCG0.47112948
118SGK10.47085673
119CDK10.44908506
120PLK10.44296593
121TRPM70.43784653
122VRK10.42812175
123ERBB20.42127813
124MAPK70.42006600
125ROCK10.41858641
126MAP2K10.41823940
127PAK60.41754758
128GSK3B0.41744104
129MAPK140.41673390
130MINK10.41181276
131MAPK130.40466710
132CSNK1D0.40019043
133PRKAA10.39517770
134TAF10.39324415
135PRKCE0.39130202
136PRKD10.39084844
137TAOK10.38874883
138MAP3K40.38556126
139INSR0.37523074
140CSNK1G10.37491174
141STK110.37324692
142AKT10.37305329
143PRPF4B0.36809082
144PRKCH0.36768388
145AKT20.35944791
146ATR0.35792472
147PTK60.35414865
148CAMK2A0.35016364
149PRKD20.34928396
150SGK4940.34357339
151SGK2230.34357339
152MELK0.33764539
153STK380.33234095
154MET0.32848371
155PAK40.32217722
156DAPK30.31706465
157PINK10.31642053

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052175.31861903
2Hedgehog signaling pathway_Homo sapiens_hsa043404.84920658
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.89791510
4Protein export_Homo sapiens_hsa030602.79086047
5Wnt signaling pathway_Homo sapiens_hsa043102.57784304
6Non-homologous end-joining_Homo sapiens_hsa034502.48935457
7Hippo signaling pathway_Homo sapiens_hsa043902.31408887
8Propanoate metabolism_Homo sapiens_hsa006402.31314874
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.20816655
10ECM-receptor interaction_Homo sapiens_hsa045122.20515664
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.11888261
12TGF-beta signaling pathway_Homo sapiens_hsa043502.11412791
13Adherens junction_Homo sapiens_hsa045202.04893699
14Melanoma_Homo sapiens_hsa052182.03064937
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89632196
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.89061421
17Phototransduction_Homo sapiens_hsa047441.87852322
18Fanconi anemia pathway_Homo sapiens_hsa034601.86546653
19Pathways in cancer_Homo sapiens_hsa052001.83576261
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80282128
21Colorectal cancer_Homo sapiens_hsa052101.76716900
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71394019
23Proteoglycans in cancer_Homo sapiens_hsa052051.69767559
24Prostate cancer_Homo sapiens_hsa052151.69034537
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68853824
26Axon guidance_Homo sapiens_hsa043601.66661527
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.63222840
28Homologous recombination_Homo sapiens_hsa034401.56577464
29Focal adhesion_Homo sapiens_hsa045101.47852927
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.46004807
31MicroRNAs in cancer_Homo sapiens_hsa052061.42908426
32Melanogenesis_Homo sapiens_hsa049161.42021548
33Lysine degradation_Homo sapiens_hsa003101.41098956
34Small cell lung cancer_Homo sapiens_hsa052221.37096492
35Endometrial cancer_Homo sapiens_hsa052131.33789015
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31331870
37Basal transcription factors_Homo sapiens_hsa030221.28396701
38Protein digestion and absorption_Homo sapiens_hsa049741.27758418
39Dilated cardiomyopathy_Homo sapiens_hsa054141.24807629
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.23557185
41cAMP signaling pathway_Homo sapiens_hsa040241.22895393
42Chronic myeloid leukemia_Homo sapiens_hsa052201.20493223
43Rap1 signaling pathway_Homo sapiens_hsa040151.20419566
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18479420
45ErbB signaling pathway_Homo sapiens_hsa040121.16068463
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15982791
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15890708
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.12848547
49Circadian rhythm_Homo sapiens_hsa047101.11966400
50Cocaine addiction_Homo sapiens_hsa050301.11917437
51MAPK signaling pathway_Homo sapiens_hsa040101.11007768
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08239377
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08090698
54Renin secretion_Homo sapiens_hsa049241.07991155
55Glioma_Homo sapiens_hsa052141.07880671
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05428129
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04908996
58Viral myocarditis_Homo sapiens_hsa054161.03380050
59Type II diabetes mellitus_Homo sapiens_hsa049301.00374283
60Linoleic acid metabolism_Homo sapiens_hsa005910.98689904
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98627060
62Amoebiasis_Homo sapiens_hsa051460.96217159
63Amphetamine addiction_Homo sapiens_hsa050310.96098723
64Ras signaling pathway_Homo sapiens_hsa040140.92084243
65Regulation of autophagy_Homo sapiens_hsa041400.90604013
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90099163
67Nucleotide excision repair_Homo sapiens_hsa034200.89512389
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89249104
69Notch signaling pathway_Homo sapiens_hsa043300.88925151
70mTOR signaling pathway_Homo sapiens_hsa041500.87945531
71Gap junction_Homo sapiens_hsa045400.87885951
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87725222
73Proteasome_Homo sapiens_hsa030500.86610090
74Nitrogen metabolism_Homo sapiens_hsa009100.86505175
75Circadian entrainment_Homo sapiens_hsa047130.85383824
76RNA polymerase_Homo sapiens_hsa030200.85147563
77Taste transduction_Homo sapiens_hsa047420.84730864
78Glutathione metabolism_Homo sapiens_hsa004800.84381081
79HTLV-I infection_Homo sapiens_hsa051660.84222035
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83465390
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.83310692
82N-Glycan biosynthesis_Homo sapiens_hsa005100.82865008
83p53 signaling pathway_Homo sapiens_hsa041150.80590811
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80086173
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79719377
86Vibrio cholerae infection_Homo sapiens_hsa051100.79419996
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79348500
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79096558
89mRNA surveillance pathway_Homo sapiens_hsa030150.78873986
90Renal cell carcinoma_Homo sapiens_hsa052110.78477918
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78324857
92Tryptophan metabolism_Homo sapiens_hsa003800.77851497
93Cholinergic synapse_Homo sapiens_hsa047250.77844283
94Estrogen signaling pathway_Homo sapiens_hsa049150.77492941
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77346198
96RNA degradation_Homo sapiens_hsa030180.76165720
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75693177
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75626159
99Caffeine metabolism_Homo sapiens_hsa002320.75572980
100AMPK signaling pathway_Homo sapiens_hsa041520.75558393
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75128958
102Morphine addiction_Homo sapiens_hsa050320.74825614
103Thyroid cancer_Homo sapiens_hsa052160.74530644
104Long-term potentiation_Homo sapiens_hsa047200.73720453
105Oocyte meiosis_Homo sapiens_hsa041140.73466764
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73288075
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.72756832
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72349469
109Glutamatergic synapse_Homo sapiens_hsa047240.72071983
110Butanoate metabolism_Homo sapiens_hsa006500.70708942
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69761318
112Non-small cell lung cancer_Homo sapiens_hsa052230.69270490
113Dopaminergic synapse_Homo sapiens_hsa047280.69116993
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68273521
115Olfactory transduction_Homo sapiens_hsa047400.67976938
116Oxytocin signaling pathway_Homo sapiens_hsa049210.67309944
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66304869
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65911743
119Cell cycle_Homo sapiens_hsa041100.64991722
120One carbon pool by folate_Homo sapiens_hsa006700.64746259
121Acute myeloid leukemia_Homo sapiens_hsa052210.64607933
122Tight junction_Homo sapiens_hsa045300.64311705
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63371735
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63273131
125Ovarian steroidogenesis_Homo sapiens_hsa049130.62358396
126Choline metabolism in cancer_Homo sapiens_hsa052310.61876142
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61819475
128GnRH signaling pathway_Homo sapiens_hsa049120.61352854
129Ether lipid metabolism_Homo sapiens_hsa005650.60742565
130Toxoplasmosis_Homo sapiens_hsa051450.60700089
131Chemical carcinogenesis_Homo sapiens_hsa052040.60637684
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.60562553
133Nicotine addiction_Homo sapiens_hsa050330.59840150
134Long-term depression_Homo sapiens_hsa047300.58872779
135Dorso-ventral axis formation_Homo sapiens_hsa043200.57178778
136Pancreatic cancer_Homo sapiens_hsa052120.55103326
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55063424
138GABAergic synapse_Homo sapiens_hsa047270.54499654
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.53132974
140Selenocompound metabolism_Homo sapiens_hsa004500.52508692
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51238199
142Alcoholism_Homo sapiens_hsa050340.51052411
143Bladder cancer_Homo sapiens_hsa052190.50919694
144FoxO signaling pathway_Homo sapiens_hsa040680.50784953
145Insulin signaling pathway_Homo sapiens_hsa049100.50685401
146Steroid biosynthesis_Homo sapiens_hsa001000.49949913
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.48965361
148beta-Alanine metabolism_Homo sapiens_hsa004100.44620957
149Arachidonic acid metabolism_Homo sapiens_hsa005900.43979803
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.43952226
151Oxidative phosphorylation_Homo sapiens_hsa001900.43787791
152Insulin resistance_Homo sapiens_hsa049310.43179663
153Retinol metabolism_Homo sapiens_hsa008300.41946044
154Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41480168
155Huntingtons disease_Homo sapiens_hsa050160.41277185
156Glucagon signaling pathway_Homo sapiens_hsa049220.39490554
157Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39465969
158Cardiac muscle contraction_Homo sapiens_hsa042600.39321718
159Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38171575
160Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36869741
161Metabolic pathways_Homo sapiens_hsa011000.36824936
162Purine metabolism_Homo sapiens_hsa002300.35469072
163Calcium signaling pathway_Homo sapiens_hsa040200.34509272
164Sphingolipid metabolism_Homo sapiens_hsa006000.34194507

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