SCX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)6.07582251
2cell-cell junction maintenance (GO:0045217)5.70573406
3mannose metabolic process (GO:0006013)5.05659252
4hemidesmosome assembly (GO:0031581)4.91322231
5actin-myosin filament sliding (GO:0033275)4.86975498
6muscle filament sliding (GO:0030049)4.86975498
7semaphorin-plexin signaling pathway (GO:0071526)4.80407121
8muscle cell fate commitment (GO:0042693)4.76968381
9chondrocyte proliferation (GO:0035988)4.67057376
10metanephric mesenchyme development (GO:0072075)4.62020274
11kidney mesenchyme development (GO:0072074)4.42746769
12cell junction maintenance (GO:0034331)4.38255717
13actin-mediated cell contraction (GO:0070252)4.20255557
14planar cell polarity pathway involved in neural tube closure (GO:0090179)4.18173818
15activation of MAPKKK activity (GO:0000185)4.17158838
16myoblast fusion (GO:0007520)4.09823493
17sarcomere organization (GO:0045214)4.06355158
18glutathione biosynthetic process (GO:0006750)3.99277359
19nonribosomal peptide biosynthetic process (GO:0019184)3.87889955
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.86861134
21positive regulation of myotube differentiation (GO:0010831)3.80203734
22skeletal muscle fiber development (GO:0048741)3.77375881
23cell-substrate junction assembly (GO:0007044)3.76501247
24epithelial cell-cell adhesion (GO:0090136)3.76051006
25* collagen fibril organization (GO:0030199)3.73500642
26regulation of skeletal muscle contraction (GO:0014819)3.73165713
27cell adhesion mediated by integrin (GO:0033627)3.70080768
28endodermal cell differentiation (GO:0035987)3.69936479
29syncytium formation by plasma membrane fusion (GO:0000768)3.69440828
30negative regulation of chondrocyte differentiation (GO:0032331)3.61531615
31bone trabecula formation (GO:0060346)3.60820460
32syncytium formation (GO:0006949)3.59560013
33positive regulation of histone deacetylation (GO:0031065)3.56228405
34negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.54921952
35negative regulation of fatty acid transport (GO:2000192)3.54349025
36skeletal muscle contraction (GO:0003009)3.53357891
37outer ear morphogenesis (GO:0042473)3.52737166
38imidazole-containing compound metabolic process (GO:0052803)3.51960936
39actin filament-based movement (GO:0030048)3.46364234
40negative regulation of macroautophagy (GO:0016242)3.39834152
41embryonic cranial skeleton morphogenesis (GO:0048701)3.37370435
42negative regulation of cell size (GO:0045792)3.36827522
43protein heterotrimerization (GO:0070208)3.36715967
44pattern specification involved in kidney development (GO:0061004)3.31924928
45G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.30793210
46regulation of ARF GTPase activity (GO:0032312)3.27782669
47organ induction (GO:0001759)3.27685358
48apoptotic process involved in morphogenesis (GO:0060561)3.27564024
49regulation of apoptotic process involved in morphogenesis (GO:1902337)3.27492218
50regulation of hydrogen peroxide metabolic process (GO:0010310)3.20764394
51basement membrane organization (GO:0071711)3.20636169
52hippo signaling (GO:0035329)3.18090800
53protein retention in ER lumen (GO:0006621)3.17144462
54regulation of histone deacetylation (GO:0031063)3.16449682
55mitochondrion transport along microtubule (GO:0047497)3.15038875
56establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.15038875
57regulation of ruffle assembly (GO:1900027)3.13576290
58facial nerve structural organization (GO:0021612)3.13357712
59positive regulation of endothelial cell apoptotic process (GO:2000353)3.10720695
60middle ear morphogenesis (GO:0042474)3.10225574
61regulation of heart morphogenesis (GO:2000826)3.07288459
62endothelial cell morphogenesis (GO:0001886)3.06465747
63endocardial cushion development (GO:0003197)3.04689873
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.04501190
65cochlea morphogenesis (GO:0090103)3.04370459
66iron coordination entity transport (GO:1901678)3.04222063
67adherens junction assembly (GO:0034333)3.03375955
68embryonic body morphogenesis (GO:0010172)3.02793866
69positive regulation of p38MAPK cascade (GO:1900745)3.02636466
70cardiac myofibril assembly (GO:0055003)3.01811415
71renal filtration (GO:0097205)3.00682484
72body morphogenesis (GO:0010171)2.99151717
73regulation of early endosome to late endosome transport (GO:2000641)2.98844223
74cytoskeletal anchoring at plasma membrane (GO:0007016)2.98185532
75actomyosin structure organization (GO:0031032)2.97865524
76wound healing, spreading of epidermal cells (GO:0035313)2.96170899
77UV protection (GO:0009650)2.95774321
78positive regulation of mast cell activation involved in immune response (GO:0033008)2.95141921
79positive regulation of mast cell degranulation (GO:0043306)2.95141921
80cellular response to vitamin D (GO:0071305)2.94813748
81response to parathyroid hormone (GO:0071107)2.94183029
82myotube cell development (GO:0014904)2.93830413
83proximal/distal pattern formation (GO:0009954)2.92518788
84peptide biosynthetic process (GO:0043043)2.92373502
85negative regulation of cartilage development (GO:0061037)2.89315849
86mRNA transcription from RNA polymerase II promoter (GO:0042789)2.86582732
87positive regulation of action potential (GO:0045760)2.86455959
88regulation of cardioblast proliferation (GO:0003264)2.84881735
89regulation of secondary heart field cardioblast proliferation (GO:0003266)2.84881735
90negative regulation of erythrocyte differentiation (GO:0045647)2.84382621
91ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.84260159
92positive regulation of protein deacetylation (GO:0090312)2.84103787
93cell-substrate adherens junction assembly (GO:0007045)2.82654654
94focal adhesion assembly (GO:0048041)2.82654654
95cellular response to vitamin (GO:0071295)2.82227084
96embryonic skeletal joint morphogenesis (GO:0060272)2.82101752
97GDP-mannose metabolic process (GO:0019673)2.81531739
98regulation of tight junction assembly (GO:2000810)2.81386345
99axon extension involved in axon guidance (GO:0048846)2.81291242
100neuron projection extension involved in neuron projection guidance (GO:1902284)2.81291242
101positive regulation of skeletal muscle tissue development (GO:0048643)2.81161867
102regulation of p38MAPK cascade (GO:1900744)2.79711335
103negative regulation of potassium ion transmembrane transport (GO:1901380)2.79410981
104mRNA transcription (GO:0009299)2.78855861
105regulation of skeletal muscle cell differentiation (GO:2001014)2.78396421
106nephron tubule formation (GO:0072079)2.76961009
107craniofacial suture morphogenesis (GO:0097094)2.76024364
108mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.76007567
109positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.75359451
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74330491
111cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.74301197
112regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74107976
113non-canonical Wnt signaling pathway (GO:0035567)2.73980256
114cranial nerve morphogenesis (GO:0021602)2.73639743
115ear development (GO:0043583)2.73545748
116glomerular basement membrane development (GO:0032836)2.73524878
117cell migration involved in sprouting angiogenesis (GO:0002042)2.73442697
118Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70982931
119polarized epithelial cell differentiation (GO:0030859)2.69769205
120positive regulation of receptor recycling (GO:0001921)2.68737495
121respiratory system process (GO:0003016)2.68591070
122muscle cell migration (GO:0014812)2.65800818
123myofibril assembly (GO:0030239)2.65418935
124collagen metabolic process (GO:0032963)2.64745490
125negative regulation of catenin import into nucleus (GO:0035414)2.64141691
126wound healing, spreading of cells (GO:0044319)2.64000811
127paraxial mesoderm development (GO:0048339)2.63991073
128protein insertion into membrane (GO:0051205)2.63452173
129neuronal ion channel clustering (GO:0045161)2.62960697
130muscle organ development (GO:0007517)2.61191600
131peptidyl-proline hydroxylation (GO:0019511)2.61095926
132cAMP biosynthetic process (GO:0006171)2.60344116
133regulation of hippo signaling (GO:0035330)2.60060447
134glial cell migration (GO:0008347)2.59728515
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59390118
136cellular component maintenance (GO:0043954)2.59177405
137regulation of protein kinase C signaling (GO:0090036)2.58869550
138regulation of establishment of planar polarity (GO:0090175)2.58322640
139embryonic camera-type eye development (GO:0031076)2.57652800
140muscle structure development (GO:0061061)2.57517755
141establishment of mitochondrion localization (GO:0051654)2.57401278
142branching involved in salivary gland morphogenesis (GO:0060445)2.57324556
143positive regulation of vesicle fusion (GO:0031340)2.57159662
144collagen catabolic process (GO:0030574)2.57141209
145collecting duct development (GO:0072044)2.56603546
146sarcoplasmic reticulum calcium ion transport (GO:0070296)2.55573935
147stress fiber assembly (GO:0043149)2.55480789
148* mesenchyme development (GO:0060485)2.54836686
149negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.54816914
150positive regulation of Cdc42 GTPase activity (GO:0043089)2.54565225
151skin morphogenesis (GO:0043589)2.54328661
152protein targeting to plasma membrane (GO:0072661)2.54112252
153response to manganese ion (GO:0010042)2.53457521
154calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.52386960
155virion attachment to host cell (GO:0019062)2.50855226
156adhesion of symbiont to host cell (GO:0044650)2.50855226
157autophagic vacuole assembly (GO:0000045)2.50337057
158peptide catabolic process (GO:0043171)2.46799298
159cell proliferation in forebrain (GO:0021846)2.46193630
160response to magnesium ion (GO:0032026)2.46076349
161glucose 6-phosphate metabolic process (GO:0051156)2.42209488
162positive regulation of synapse maturation (GO:0090129)2.42155517
163activation of Rac GTPase activity (GO:0032863)2.41251101
164regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.41077405
165adenosine receptor signaling pathway (GO:0001973)2.40466090
166vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.36834427
167apoptotic process involved in development (GO:1902742)2.36014732
168negative regulation of axon extension involved in axon guidance (GO:0048843)2.33847032
169positive regulation of protein kinase C signaling (GO:0090037)2.33593127
170regulation of glycogen (starch) synthase activity (GO:2000465)2.33147363
171establishment or maintenance of monopolar cell polarity (GO:0061339)2.32150507
172establishment of monopolar cell polarity (GO:0061162)2.32150507
173white fat cell differentiation (GO:0050872)2.31657045
174glycosphingolipid catabolic process (GO:0046479)2.31413954
175dopamine receptor signaling pathway (GO:0007212)2.31142568
176specification of organ identity (GO:0010092)2.30785122
177metanephric nephron epithelium development (GO:0072243)2.30282902
178positive regulation of lymphocyte apoptotic process (GO:0070230)2.30030521
179positive regulation of filopodium assembly (GO:0051491)2.29927201
180synaptic vesicle endocytosis (GO:0048488)2.29867363
181adhesion of symbiont to host (GO:0044406)2.29014474
182tooth mineralization (GO:0034505)2.27834363
183positive regulation of leukocyte degranulation (GO:0043302)2.27555584
184positive regulation of T cell apoptotic process (GO:0070234)2.25677093
185activation of JUN kinase activity (GO:0007257)2.25565488
186renal system development (GO:0072001)2.24699091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.01661084
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.14079477
3* TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.52533965
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.25378527
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.12699502
6CLOCK_20551151_ChIP-Seq_293T_Human2.74146764
7VDR_21846776_ChIP-Seq_THP-1_Human2.69727141
8* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.62835692
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.60292245
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.46822608
11* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.38294331
12* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.37761360
13ZNF263_19887448_ChIP-Seq_K562_Human2.26933019
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21099031
15TP53_20018659_ChIP-ChIP_R1E_Mouse2.08225227
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.06347401
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.05893088
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04606104
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03050567
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01907158
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.01813061
22P68_20966046_ChIP-Seq_HELA_Human2.00802580
23ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99737722
24* TET1_21451524_ChIP-Seq_MESCs_Mouse1.96677404
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.91254016
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.83430083
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81559240
28RACK7_27058665_Chip-Seq_MCF-7_Human1.81263971
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.80144435
30* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.79055868
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75220394
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75220394
33CTCF_27219007_Chip-Seq_Bcells_Human1.75021287
34SMC4_20622854_ChIP-Seq_HELA_Human1.74741715
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.71119403
36TCF7_22412390_ChIP-Seq_EML_Mouse1.70567643
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.69348042
38* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.67605395
39* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.66710377
40ATF3_27146783_Chip-Seq_COLON_Human1.66499043
41KDM2B_26808549_Chip-Seq_K562_Human1.66092872
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65310290
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65221917
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64411344
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.64341270
46DROSHA_22980978_ChIP-Seq_HELA_Human1.62623202
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61573029
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60598084
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60598084
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.60417135
51LXR_22292898_ChIP-Seq_THP-1_Human1.60337154
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58966619
53* TBX20_22328084_ChIP-Seq_HEART_Mouse1.56985216
54* TBX20_22080862_ChIP-Seq_HEART_Mouse1.56985216
55* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56934928
56CJUN_26792858_Chip-Seq_BT549_Human1.56912502
57KDM2B_26808549_Chip-Seq_DND41_Human1.55773991
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55348775
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54104354
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54082231
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54074907
62BCL6_27268052_Chip-Seq_Bcells_Human1.53968707
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52992063
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.50771044
65MYC_22102868_ChIP-Seq_BL_Human1.48243257
66MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.47304173
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45097500
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.44281755
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43902474
70BRD4_25478319_ChIP-Seq_HGPS_Human1.43901286
71MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.43797904
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43752166
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42272897
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.41966011
75* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40664333
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40308549
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.39179789
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.39040333
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38809062
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38609835
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38164914
82BCOR_27268052_Chip-Seq_Bcells_Human1.38117604
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37822044
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37700227
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36433536
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35515389
87* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34929404
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33481232
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30525399
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28264304
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28163523
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27736374
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.27719592
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27535266
95STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.26472746
96CREB1_26743006_Chip-Seq_LNCaP_Human1.25692769
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.25350643
98TP53_22127205_ChIP-Seq_IMR90_Human1.22200900
99MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21502513
100* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20608054
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.20590199
102JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19903170
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19511429
104VDR_24763502_ChIP-Seq_THP-1_Human1.19369241
105EGR1_19374776_ChIP-ChIP_THP-1_Human1.19188633
106OCT4_19829295_ChIP-Seq_ESCs_Human1.19182486
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.18098457
108SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17927412
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17799687
110TP63_22573176_ChIP-Seq_HFKS_Human1.17540642
111SA1_27219007_Chip-Seq_Bcells_Human1.17467802
112EZH2_27294783_Chip-Seq_ESCs_Mouse1.16993738
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.16749201
114* TP53_23651856_ChIP-Seq_MEFs_Mouse1.15492854
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.15449804
116EZH2_27304074_Chip-Seq_ESCs_Mouse1.14812813
117PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13693568
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13412438
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.13257057
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.13132404
121E2F1_20622854_ChIP-Seq_HELA_Human1.11812525
122CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11618077
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11428098
124RARB_24833708_ChIP-Seq_LIVER_Mouse1.11332691
125SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11215919
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10955548
127ISL1_27105846_Chip-Seq_CPCs_Mouse1.10755117
128CTCF_20526341_ChIP-Seq_ESCs_Human1.10376658
129PHF8_20622854_ChIP-Seq_HELA_Human1.10265217
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09182596
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09122733
132CTCF_26484167_Chip-Seq_Bcells_Mouse1.08649175
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08278448
134EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08211543
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07949299
136CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07668655
137IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06964855
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06760649
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06025839
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05156338
141EZH2_22144423_ChIP-Seq_EOC_Human1.05063381
142P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04811533
143SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04685381
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04218737
145KLF5_25053715_ChIP-Seq_YYC3_Human1.03980504
146MAF_26560356_Chip-Seq_TH2_Human1.03260974
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03118592
148NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02702692
149SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02364113
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01990236
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99778845
152JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99601181
153CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98069457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.14778410
2MP0009840_abnormal_foam_cell3.90345393
3MP0005623_abnormal_meninges_morphology3.59620989
4MP0000751_myopathy3.53744076
5MP0005058_abnormal_lysosome_morphology3.36951494
6MP0010030_abnormal_orbit_morphology3.35313262
7MP0003879_abnormal_hair_cell3.26948198
8MP0003705_abnormal_hypodermis_morpholog3.23835841
9MP0000733_abnormal_muscle_development2.86940096
10MP0000749_muscle_degeneration2.70230855
11MP0004233_abnormal_muscle_weight2.54233005
12* MP0005503_abnormal_tendon_morphology2.42272968
13MP0005275_abnormal_skin_tensile2.41891518
14MP0000750_abnormal_muscle_regeneration2.39979075
15MP0003385_abnormal_body_wall2.38993281
16MP0005257_abnormal_intraocular_pressure2.38060676
17MP0003787_abnormal_imprinting2.33490711
18MP0003646_muscle_fatigue2.31330408
19MP0004272_abnormal_basement_membrane2.15501381
20MP0009250_abnormal_appendicular_skeleto2.11982287
21MP0003279_aneurysm2.10639586
22MP0005451_abnormal_body_composition2.07069649
23MP0003566_abnormal_cell_adhesion2.06096054
24MP0003183_abnormal_peptide_metabolism2.04846069
25MP0002877_abnormal_melanocyte_morpholog2.03510609
26MP0004145_abnormal_muscle_electrophysio2.01807804
27MP0000747_muscle_weakness2.00053966
28MP0003453_abnormal_keratinocyte_physiol1.99285311
29MP0000759_abnormal_skeletal_muscle1.97485882
30MP0003941_abnormal_skin_development1.94370134
31MP0004087_abnormal_muscle_fiber1.92061434
32MP0003172_abnormal_lysosome_physiology1.85778165
33MP0000013_abnormal_adipose_tissue1.84194045
34MP0009053_abnormal_anal_canal1.83783391
35MP0004084_abnormal_cardiac_muscle1.79051827
36MP0002269_muscular_atrophy1.77296066
37MP0004510_myositis1.77043607
38MP0001958_emphysema1.72974447
39MP0003942_abnormal_urinary_system1.71630172
40MP0001299_abnormal_eye_distance/1.69765014
41MP0005666_abnormal_adipose_tissue1.69451301
42MP0000534_abnormal_ureter_morphology1.69271441
43MP0002060_abnormal_skin_morphology1.68867688
44MP0000428_abnormal_craniofacial_morphol1.68005772
45MP0001873_stomach_inflammation1.66714920
46MP0005083_abnormal_biliary_tract1.63824222
47MP0000678_abnormal_parathyroid_gland1.62836754
48MP0000681_abnormal_thyroid_gland1.62685960
49MP0005330_cardiomyopathy1.60572621
50* MP0002108_abnormal_muscle_morphology1.58739817
51MP0000762_abnormal_tongue_morphology1.58142361
52MP0009384_cardiac_valve_regurgitation1.57912365
53MP0002106_abnormal_muscle_physiology1.55356645
54MP0002837_dystrophic_cardiac_calcinosis1.55315610
55MP0003091_abnormal_cell_migration1.53197829
56MP0001346_abnormal_lacrimal_gland1.48390857
57MP0002249_abnormal_larynx_morphology1.47604698
58* MP0005369_muscle_phenotype1.46733362
59* MP0005508_abnormal_skeleton_morphology1.46226188
60MP0005670_abnormal_white_adipose1.43200163
61MP0005023_abnormal_wound_healing1.36554721
62MP0003755_abnormal_palate_morphology1.36435090
63MP0000537_abnormal_urethra_morphology1.33191083
64MP0010352_gastrointestinal_tract_polyps1.29382365
65MP0002254_reproductive_system_inflammat1.29282008
66MP0000049_abnormal_middle_ear1.27690772
67MP0002735_abnormal_chemical_nociception1.27594553
68MP0001849_ear_inflammation1.26839772
69MP0002932_abnormal_joint_morphology1.26770073
70MP0001348_abnormal_lacrimal_gland1.22284376
71MP0003283_abnormal_digestive_organ1.20966462
72MP0002234_abnormal_pharynx_morphology1.20765258
73MP0005409_darkened_coat_color1.19172762
74MP0000003_abnormal_adipose_tissue1.19143754
75MP0002896_abnormal_bone_mineralization1.18130597
76MP0003123_paternal_imprinting1.17929823
77MP0004130_abnormal_muscle_cell1.17820303
78MP0003937_abnormal_limbs/digits/tail_de1.16159193
79MP0000767_abnormal_smooth_muscle1.16009157
80MP0002233_abnormal_nose_morphology1.14806892
81MP0010630_abnormal_cardiac_muscle1.11011107
82MP0003115_abnormal_respiratory_system1.10604053
83MP0001502_abnormal_circadian_rhythm1.10059922
84MP0002168_other_aberrant_phenotype1.03455850
85MP0009780_abnormal_chondrocyte_physiolo1.03361684
86MP0004036_abnormal_muscle_relaxation1.03236114
87MP0002114_abnormal_axial_skeleton1.01666329
88MP0004859_abnormal_synaptic_plasticity1.00919537
89MP0002972_abnormal_cardiac_muscle1.00896816
90MP0002184_abnormal_innervation1.00621609
91MP0000163_abnormal_cartilage_morphology1.00620272
92MP0005620_abnormal_muscle_contractility1.00273709
93MP0002332_abnormal_exercise_endurance1.00272277
94MP0003935_abnormal_craniofacial_develop0.99740721
95MP0005248_abnormal_Harderian_gland0.99653771
96MP0002822_catalepsy0.96984988
97MP0003122_maternal_imprinting0.96733901
98MP0010386_abnormal_urinary_bladder0.96231277
99MP0002282_abnormal_trachea_morphology0.96112834
100MP0008260_abnormal_autophagy0.95186752
101MP0001542_abnormal_bone_strength0.95142108
102MP0004381_abnormal_hair_follicle0.94327449
103MP0003806_abnormal_nucleotide_metabolis0.93761444
104MP0002177_abnormal_outer_ear0.93121279
105MP0005381_digestive/alimentary_phenotyp0.92969358
106MP0001663_abnormal_digestive_system0.92800949
107MP0005197_abnormal_uvea_morphology0.92528695
108* MP0002115_abnormal_skeleton_extremities0.92257568
109MP0006138_congestive_heart_failure0.90953055
110MP0000467_abnormal_esophagus_morphology0.90183362
111MP0005076_abnormal_cell_differentiation0.89857537
112MP0002971_abnormal_brown_adipose0.89771760
113MP0005377_hearing/vestibular/ear_phenot0.87701720
114MP0003878_abnormal_ear_physiology0.87701720
115MP0001340_abnormal_eyelid_morphology0.87416949
116MP0001270_distended_abdomen0.87330458
117MP0003300_gastrointestinal_ulcer0.85860696
118MP0002116_abnormal_craniofacial_bone0.85405133
119MP0002796_impaired_skin_barrier0.83210451
120MP0000432_abnormal_head_morphology0.82414119
121MP0005423_abnormal_somatic_nervous0.80378002
122* MP0002109_abnormal_limb_morphology0.80096244
123MP0003329_amyloid_beta_deposits0.79756011
124MP0004858_abnormal_nervous_system0.77067659
125MP0002734_abnormal_mechanical_nocicepti0.76551803
126MP0002089_abnormal_postnatal_growth/wei0.76497597
127MP0004185_abnormal_adipocyte_glucose0.76053294
128MP0005595_abnormal_vascular_smooth0.74657415
129MP0003191_abnormal_cellular_cholesterol0.73753653
130* MP0002113_abnormal_skeleton_development0.73734212
131MP0004197_abnormal_fetal_growth/weight/0.71902545
132MP0010234_abnormal_vibrissa_follicle0.71307505
133MP0005193_abnormal_anterior_eye0.71163457
134MP0001544_abnormal_cardiovascular_syste0.71027845
135MP0005385_cardiovascular_system_phenoty0.71027845
136MP0000026_abnormal_inner_ear0.70967438
137MP0003436_decreased_susceptibility_to0.70633834
138MP0001970_abnormal_pain_threshold0.70587039
139MP0002998_abnormal_bone_remodeling0.70058102
140MP0010368_abnormal_lymphatic_system0.69923218
141MP0008007_abnormal_cellular_replicative0.69893671
142MP0004133_heterotaxia0.69529212
143MP0005375_adipose_tissue_phenotype0.68695527
144MP0001243_abnormal_dermal_layer0.67468427
145MP0002733_abnormal_thermal_nociception0.67271773
146MP0002092_abnormal_eye_morphology0.66898060
147MP0002128_abnormal_blood_circulation0.66779253
148* MP0005390_skeleton_phenotype0.65839964
149MP0003634_abnormal_glial_cell0.65553828
150MP0002933_joint_inflammation0.65440390
151MP0008775_abnormal_heart_ventricle0.64874915
152MP0000470_abnormal_stomach_morphology0.63672220
153MP0003638_abnormal_response/metabolism_0.63450419
154MP0005501_abnormal_skin_physiology0.60558839

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)4.87988181
2Premature rupture of membranes (HP:0001788)4.82301569
3Stridor (HP:0010307)4.53748030
4Popliteal pterygium (HP:0009756)4.31496830
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.27648185
6Protrusio acetabuli (HP:0003179)4.20236904
7Muscle fiber inclusion bodies (HP:0100299)4.08143187
8Round ear (HP:0100830)4.07145367
9Fetal akinesia sequence (HP:0001989)3.95716249
10Aplasia of the musculature (HP:0100854)3.89844993
11J-shaped sella turcica (HP:0002680)3.88753941
12Nemaline bodies (HP:0003798)3.81305923
13Increased connective tissue (HP:0009025)3.68433079
14Malignant hyperthermia (HP:0002047)3.67950363
15Distal arthrogryposis (HP:0005684)3.62804955
16Muscle fiber splitting (HP:0003555)3.53882709
17Obstructive sleep apnea (HP:0002870)3.52989407
18Difficulty climbing stairs (HP:0003551)3.52592807
19Shallow orbits (HP:0000586)3.42400323
20Amniotic constriction ring (HP:0009775)3.39559433
21Abnormality of placental membranes (HP:0011409)3.39559433
22Pterygium (HP:0001059)3.38683964
23Fatigable weakness (HP:0003473)3.31449016
24Abnormality of the neuromuscular junction (HP:0003398)3.31449016
25Thin ribs (HP:0000883)3.28316175
26Hyporeflexia of lower limbs (HP:0002600)3.21828538
27Calcaneovalgus deformity (HP:0001848)3.19909846
28Scapular winging (HP:0003691)3.13588638
29Joint stiffness (HP:0001387)3.13293577
30Deformed tarsal bones (HP:0008119)3.10273200
31Increased variability in muscle fiber diameter (HP:0003557)3.09132061
32Absent phalangeal crease (HP:0006109)3.05567370
33Abnormality of skeletal muscle fiber size (HP:0012084)3.03125190
34Mildly elevated creatine phosphokinase (HP:0008180)3.03063150
35Abnormality of the calf musculature (HP:0001430)3.01176668
36Dysostosis multiplex (HP:0000943)2.97594222
37Type 2 muscle fiber atrophy (HP:0003554)2.92509857
38Diaphragmatic weakness (HP:0009113)2.92440204
39Weak cry (HP:0001612)2.92351539
40Abnormality of liposaccharide metabolism (HP:0010968)2.90916136
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.90916136
42Abnormality of glycolipid metabolism (HP:0010969)2.90916136
43Muscle fiber atrophy (HP:0100295)2.83798714
44Ankle contracture (HP:0006466)2.83305686
45Asymmetric septal hypertrophy (HP:0001670)2.82996419
46Nuclear cataract (HP:0100018)2.82670010
47Ulnar bowing (HP:0003031)2.79343450
48Spinal rigidity (HP:0003306)2.78446428
49Difficulty running (HP:0009046)2.78183318
50Ulnar deviation of the wrist (HP:0003049)2.77085276
51Broad face (HP:0000283)2.76939900
52Atrophic scars (HP:0001075)2.75242462
53Abnormality of the calcaneus (HP:0008364)2.74957324
54Hip contracture (HP:0003273)2.72618294
55Fragile skin (HP:0001030)2.71852386
56Hyperthyroidism (HP:0000836)2.68691800
57Broad metatarsal (HP:0001783)2.68365523
58EMG: myopathic abnormalities (HP:0003458)2.66055124
59Cerebral aneurysm (HP:0004944)2.64808989
60Gowers sign (HP:0003391)2.62630476
61Thin bony cortex (HP:0002753)2.62080467
62Mucopolysacchariduria (HP:0008155)2.53940941
63Urinary glycosaminoglycan excretion (HP:0003541)2.53940941
64Akinesia (HP:0002304)2.52133095
65Distal lower limb amyotrophy (HP:0008944)2.51479202
66Abnormal finger flexion creases (HP:0006143)2.50904416
67Abnormality of polysaccharide metabolism (HP:0011012)2.48804682
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.48804682
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.48804682
70Cervical subluxation (HP:0003308)2.48659551
71Deformed sella turcica (HP:0002681)2.45285085
72Thoracic kyphosis (HP:0002942)2.44126740
73Right ventricular cardiomyopathy (HP:0011663)2.43462335
74Limb-girdle muscle atrophy (HP:0003797)2.43020589
75Myopathic facies (HP:0002058)2.38800981
76Tetany (HP:0001281)2.37905027
77Renal tubular acidosis (HP:0001947)2.35255075
78Aortic dissection (HP:0002647)2.33813665
79Aortic regurgitation (HP:0001659)2.33089991
80Wrist flexion contracture (HP:0001239)2.31543655
81Fragile nails (HP:0001808)2.27792365
82Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.24316165
83Distal lower limb muscle weakness (HP:0009053)2.23709310
84Sudden death (HP:0001699)2.21796892
85Trismus (HP:0000211)2.20620003
86Knee flexion contracture (HP:0006380)2.20413105
87Turricephaly (HP:0000262)2.19697411
88Colitis (HP:0002583)2.19423563
89Soft skin (HP:0000977)2.18636876
90Abnormality of the vertebral endplates (HP:0005106)2.16141985
91Abnormality of the femoral head (HP:0003368)2.16071173
92Bulbar palsy (HP:0001283)2.13667348
93Aplasia/Hypoplasia involving the musculature (HP:0001460)2.12735245
94Abnormality of dentin (HP:0010299)2.12517245
95Neurofibrillary tangles (HP:0002185)2.11098458
96Down-sloping shoulders (HP:0200021)2.10529169
97Bowed forearm bones (HP:0003956)2.08574962
98Bowing of the arm (HP:0006488)2.08574962
99Limited hip movement (HP:0008800)2.08541075
100Elbow flexion contracture (HP:0002987)2.08273497
101Hypoplastic heart (HP:0001961)2.08219682
102Axonal loss (HP:0003447)2.06898461
103Achilles tendon contracture (HP:0001771)2.06881955
104Bladder diverticulum (HP:0000015)2.06759420
105Exercise-induced myalgia (HP:0003738)2.05224773
106Calf muscle hypertrophy (HP:0008981)2.03603293
107Abnormalities of placenta or umbilical cord (HP:0001194)2.03545545
108Exercise-induced muscle cramps (HP:0003710)2.01133588
109Upper limb amyotrophy (HP:0009129)1.99904216
110Distal upper limb amyotrophy (HP:0007149)1.99904216
111Chin dimple (HP:0010751)1.99897671
112Mitral valve prolapse (HP:0001634)1.99769691
113Coxa vara (HP:0002812)1.99185311
114Lower limb amyotrophy (HP:0007210)1.99109459
115Abnormal drinking behavior (HP:0030082)1.98719996
116Polydipsia (HP:0001959)1.98719996
117Muscle hypertrophy of the lower extremities (HP:0008968)1.98489133
118Ankle clonus (HP:0011448)1.98256173
119EMG: neuropathic changes (HP:0003445)1.96944874
120Waddling gait (HP:0002515)1.96795058
121Abnormality of the epiphysis of the femoral head (HP:0010574)1.96682163
122Overgrowth (HP:0001548)1.96663298
123Short nail (HP:0001799)1.96412048
124Increased density of long bones (HP:0006392)1.95654797
125Hyperacusis (HP:0010780)1.95325791
126Peritonitis (HP:0002586)1.94559438
127Abnormality of the distal phalanges of the toes (HP:0010182)1.94514674
128Abnormality of the shoulder girdle musculature (HP:0001435)1.94388679
129Hypoplastic ischia (HP:0003175)1.93643404
130Flat capital femoral epiphysis (HP:0003370)1.93586253
131Bronchomalacia (HP:0002780)1.92688074
132Camptodactyly of toe (HP:0001836)1.90761865
133Flattened epiphyses (HP:0003071)1.90057563
134Tarsal synostosis (HP:0008368)1.89990954
135Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.89764539
136Abnormality of femoral epiphyses (HP:0006499)1.89764539
137Generalized muscle weakness (HP:0003324)1.87868425
138Easy fatigability (HP:0003388)1.87072899
139Limb-girdle muscle weakness (HP:0003325)1.86841357
140Prolonged neonatal jaundice (HP:0006579)1.86788267
141Neonatal short-limb short stature (HP:0008921)1.86648227
142Dilatation of the ascending aorta (HP:0005111)1.86520445
143Respiratory insufficiency due to muscle weakness (HP:0002747)1.85390949
144Mesomelia (HP:0003027)1.84981998
145Retinal atrophy (HP:0001105)1.84022141
146Myotonia (HP:0002486)1.83619937
147Abnormality of the 2nd finger (HP:0004100)1.82798101
148Coronal craniosynostosis (HP:0004440)1.81771664
149Infantile muscular hypotonia (HP:0008947)1.81553158
150Abnormality of the thoracic spine (HP:0100711)1.81474006
151Hypophosphatemia (HP:0002148)1.81251220
152Neck muscle weakness (HP:0000467)1.80976496
153Protuberant abdomen (HP:0001538)1.80553366
154Genu recurvatum (HP:0002816)1.80498645
155Supranuclear gaze palsy (HP:0000605)1.80330926
156Increased serum ferritin (HP:0003281)1.80078856
157Hyperparathyroidism (HP:0000843)1.79717250
158Mitral regurgitation (HP:0001653)1.79183022
159Lymphangioma (HP:0100764)1.75980647
160Polygenic inheritance (HP:0010982)1.75595914
161Increased cerebral lipofuscin (HP:0011813)1.74896075
162Short femoral neck (HP:0100864)1.74202339
163Abnormality of the Achilles tendon (HP:0005109)1.73911958
164Bundle branch block (HP:0011710)1.73454064
165Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.72090641
166Aplasia/hypoplasia of the femur (HP:0005613)1.72011855
167Abnormality of lateral ventricle (HP:0030047)1.71942490
168Lumbar hyperlordosis (HP:0002938)1.71771200
169Abdominal distention (HP:0003270)1.71318470
170Hypercalciuria (HP:0002150)1.70915301
171Bell-shaped thorax (HP:0001591)1.70759091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.81832959
2TRIB35.18903281
3TTN4.87768649
4PKN22.98189490
5DDR22.97716768
6MOS2.65401618
7IRAK32.63241147
8TLK12.46147634
9EPHB22.41273683
10PDGFRA2.41134657
11ERN12.26081569
12LATS12.14057184
13LRRK22.13373720
14LATS22.10751933
15MAP3K61.94801129
16ILK1.84584186
17MAP3K101.82380820
18PIK3CG1.78024760
19EPHA21.77238377
20PTK61.73237309
21PAK41.72463517
22PAK31.61306041
23MARK21.59203595
24MUSK1.53580449
25PAK21.50627068
26FER1.49072063
27TAOK11.43971701
28RIPK11.43927601
29BMX1.40730661
30PTK21.40314549
31ROCK21.38368615
32EEF2K1.36547470
33PIM21.36481443
34MAP3K111.32629320
35TRPM71.32186989
36TBK11.31949056
37MAP2K11.31263098
38OBSCN1.30568219
39TGFBR11.27530504
40MST1R1.24487600
41DYRK31.23948705
42MET1.20836191
43MAPKAPK31.15064838
44RPS6KA61.13787917
45ROCK11.13688440
46EPHB11.10306502
47LIMK11.09628461
48DAPK31.08855136
49MARK31.08580285
50MAP2K61.06916403
51SIK21.03973180
52DAPK20.98877129
53TNK20.94302703
54MAP3K30.91096942
55NTRK10.90247014
56RPS6KB20.89850548
57ERBB30.89082441
58CDK60.88366635
59MAP2K30.85232073
60MAP3K10.84946684
61TAOK20.84274534
62NEK90.82552315
63PIK3CA0.82119837
64PTK2B0.81528331
65FGFR10.81223998
66CDK150.81129420
67CDK140.80922817
68MAP4K10.79272797
69PHKG20.79198649
70PHKG10.79198649
71SMG10.78851126
72MAPK120.78231562
73MTOR0.77102563
74NTRK30.76518726
75CDK180.74357670
76CDK80.74054763
77CDK11A0.73854693
78PRPF4B0.73047207
79NME10.71656685
80STK160.70873631
81ARAF0.70868563
82PRKD10.70391867
83PAK60.69904348
84MAP3K90.67705495
85CSK0.66549462
86DYRK1B0.66510330
87ABL20.66482652
88STK30.66013602
89CHUK0.64654867
90PDGFRB0.63803860
91MATK0.63203106
92DMPK0.62964385
93LMTK20.62201302
94TYRO30.62189127
95PAK10.61588125
96MARK10.58817975
97MAPK40.58748726
98TGFBR20.57613721
99NTRK20.56598110
100STK38L0.56010998
101AKT20.55905771
102MAP2K20.55612293
103MAP3K130.55352718
104CDK120.55268886
105PRKCH0.53969806
106PDPK10.53343117
107NME20.52595984
108PRKD20.52458096
109STK100.51457149
110BRAF0.50340125
111SIK10.50319013
112PKN10.50080410
113MYLK0.49174355
114BCKDK0.48309133
115FGFR20.48261710
116DAPK10.48237900
117PRKCI0.45015878
118CAMK2G0.44254790
119ICK0.44218122
120RPS6KA10.43823486
121RET0.43179614
122CDC42BPA0.42886647
123ZAK0.42452769
124ADRBK10.42363924
125RPS6KA20.42143157
126MINK10.41352861
127MAP3K80.40534676
128BMPR1B0.40198687
129MAP2K70.39780481
130INSR0.38163235
131IKBKB0.38144425
132GSK3A0.37894599
133SIK30.37888222
134WNK10.37693582
135STK380.36589139
136WNK40.36426825
137TESK10.34126362
138CAMK2B0.33793918
139PRKAA10.32401523
140MAPK80.32362250
141CAMKK10.32116268
142IRAK40.31716462
143PRKD30.30448161
144MELK0.29810830
145HIPK20.29405647
146ALK0.28008241
147MAPK90.27988815
148RPS6KC10.27404129
149RPS6KL10.27404129
150MAP3K70.26787918

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.34515250
2Dilated cardiomyopathy_Homo sapiens_hsa054143.42506735
3ECM-receptor interaction_Homo sapiens_hsa045123.28379208
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.25106141
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.19543644
6Focal adhesion_Homo sapiens_hsa045102.72634994
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.70976774
8Proteoglycans in cancer_Homo sapiens_hsa052052.52212998
9Bladder cancer_Homo sapiens_hsa052192.46872316
10Basal cell carcinoma_Homo sapiens_hsa052172.31550519
11Hippo signaling pathway_Homo sapiens_hsa043902.29613352
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98370414
13Tight junction_Homo sapiens_hsa045301.97853040
14Hedgehog signaling pathway_Homo sapiens_hsa043401.89691624
15Amoebiasis_Homo sapiens_hsa051461.84425876
16Chronic myeloid leukemia_Homo sapiens_hsa052201.78800598
17Lysosome_Homo sapiens_hsa041421.78276930
18Adherens junction_Homo sapiens_hsa045201.75336982
19Cardiac muscle contraction_Homo sapiens_hsa042601.62327016
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60855895
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.60409220
22Melanogenesis_Homo sapiens_hsa049161.60103262
23TGF-beta signaling pathway_Homo sapiens_hsa043501.57261251
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56687807
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54960202
26Small cell lung cancer_Homo sapiens_hsa052221.54254053
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51068503
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49853966
29Axon guidance_Homo sapiens_hsa043601.49353802
30Glioma_Homo sapiens_hsa052141.45689323
31Melanoma_Homo sapiens_hsa052181.44744869
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40477427
33Fructose and mannose metabolism_Homo sapiens_hsa000511.39454598
34Galactose metabolism_Homo sapiens_hsa000521.35742358
35Protein digestion and absorption_Homo sapiens_hsa049741.35496358
36Synaptic vesicle cycle_Homo sapiens_hsa047211.34247514
37MicroRNAs in cancer_Homo sapiens_hsa052061.34243118
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.33648351
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.32621060
40Ribosome_Homo sapiens_hsa030101.29849782
41Viral myocarditis_Homo sapiens_hsa054161.28494987
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25122220
43Gap junction_Homo sapiens_hsa045401.21154937
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16852940
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.15764053
46Wnt signaling pathway_Homo sapiens_hsa043101.14258085
47Renal cell carcinoma_Homo sapiens_hsa052111.13053030
48Prion diseases_Homo sapiens_hsa050201.12767920
49PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12354015
50Prostate cancer_Homo sapiens_hsa052151.10170081
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08414012
52Estrogen signaling pathway_Homo sapiens_hsa049151.07242319
53Hepatitis C_Homo sapiens_hsa051601.07049035
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.04923122
55Oxytocin signaling pathway_Homo sapiens_hsa049211.04517870
56Notch signaling pathway_Homo sapiens_hsa043301.01784433
57Histidine metabolism_Homo sapiens_hsa003400.98419736
58Endometrial cancer_Homo sapiens_hsa052130.96187394
59GnRH signaling pathway_Homo sapiens_hsa049120.95560779
60Rap1 signaling pathway_Homo sapiens_hsa040150.95206518
61HTLV-I infection_Homo sapiens_hsa051660.95054446
62Pathways in cancer_Homo sapiens_hsa052000.94123492
63Insulin signaling pathway_Homo sapiens_hsa049100.93442820
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92254011
65VEGF signaling pathway_Homo sapiens_hsa043700.90502342
66Sphingolipid metabolism_Homo sapiens_hsa006000.89852669
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89366696
68Osteoclast differentiation_Homo sapiens_hsa043800.89120085
69Pancreatic cancer_Homo sapiens_hsa052120.88633514
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86973773
71TNF signaling pathway_Homo sapiens_hsa046680.86671687
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85870202
73B cell receptor signaling pathway_Homo sapiens_hsa046620.84516174
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.81933998
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79504590
76Platelet activation_Homo sapiens_hsa046110.79373765
77Collecting duct acid secretion_Homo sapiens_hsa049660.79217887
78AMPK signaling pathway_Homo sapiens_hsa041520.78915271
79Non-small cell lung cancer_Homo sapiens_hsa052230.77772697
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75896059
81ErbB signaling pathway_Homo sapiens_hsa040120.74601109
82Thyroid cancer_Homo sapiens_hsa052160.74428526
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73578405
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72263016
85MAPK signaling pathway_Homo sapiens_hsa040100.71763871
86Insulin secretion_Homo sapiens_hsa049110.71634902
87Salivary secretion_Homo sapiens_hsa049700.71290565
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71266832
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.70139546
90Arginine biosynthesis_Homo sapiens_hsa002200.69938918
91Ovarian steroidogenesis_Homo sapiens_hsa049130.69605772
92mTOR signaling pathway_Homo sapiens_hsa041500.69130732
93Malaria_Homo sapiens_hsa051440.68578138
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67684732
95Choline metabolism in cancer_Homo sapiens_hsa052310.66599631
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63814438
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63282787
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63125707
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62340846
100Thyroid hormone synthesis_Homo sapiens_hsa049180.61782015
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61314446
102Salmonella infection_Homo sapiens_hsa051320.60885419
103HIF-1 signaling pathway_Homo sapiens_hsa040660.60863823
104Acute myeloid leukemia_Homo sapiens_hsa052210.60854258
105Viral carcinogenesis_Homo sapiens_hsa052030.60777720
106Gastric acid secretion_Homo sapiens_hsa049710.60760161
107FoxO signaling pathway_Homo sapiens_hsa040680.60756896
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60043591
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60008869
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59985341
111Vibrio cholerae infection_Homo sapiens_hsa051100.59492904
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.59471803
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58426666
114Dopaminergic synapse_Homo sapiens_hsa047280.57939922
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.57798281
116Prolactin signaling pathway_Homo sapiens_hsa049170.55855787
117Colorectal cancer_Homo sapiens_hsa052100.54729116
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54713462
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54393745
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53119112
121Toxoplasmosis_Homo sapiens_hsa051450.52503330
122Endocytosis_Homo sapiens_hsa041440.52008699
123p53 signaling pathway_Homo sapiens_hsa041150.51863870
124Long-term depression_Homo sapiens_hsa047300.51761856
125Renin-angiotensin system_Homo sapiens_hsa046140.51662120
126Apoptosis_Homo sapiens_hsa042100.51268560
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51208176
128Cocaine addiction_Homo sapiens_hsa050300.50586869
129Long-term potentiation_Homo sapiens_hsa047200.49154793
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49056557
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48849687
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48528299
133Dorso-ventral axis formation_Homo sapiens_hsa043200.47016410
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.46602051
135Sulfur relay system_Homo sapiens_hsa041220.45914303
136Alzheimers disease_Homo sapiens_hsa050100.45730206
137Cholinergic synapse_Homo sapiens_hsa047250.45648529
138Renin secretion_Homo sapiens_hsa049240.45023789
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44937113
140Glucagon signaling pathway_Homo sapiens_hsa049220.43774229
141Shigellosis_Homo sapiens_hsa051310.42690812
142Ras signaling pathway_Homo sapiens_hsa040140.42476994
143Insulin resistance_Homo sapiens_hsa049310.41632955
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.38756423
145Parkinsons disease_Homo sapiens_hsa050120.38297439
146Phenylalanine metabolism_Homo sapiens_hsa003600.37629337

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