SCYL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.92727884
2Golgi transport vesicle coating (GO:0048200)5.92727884
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.42071621
4activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.22103445
5protein retention in ER lumen (GO:0006621)4.14724505
6plasma membrane repair (GO:0001778)4.11847481
7apoptotic cell clearance (GO:0043277)4.01352866
8positive regulation of nuclease activity (GO:0032075)3.98295641
94-hydroxyproline metabolic process (GO:0019471)3.87206775
10proline biosynthetic process (GO:0006561)3.74833741
11negative regulation of cell size (GO:0045792)3.69550376
12* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.68566836
13low-density lipoprotein particle clearance (GO:0034383)3.65450130
14endoplasmic reticulum unfolded protein response (GO:0030968)3.61250182
15regulation of nuclease activity (GO:0032069)3.60300618
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.52891817
17lysine metabolic process (GO:0006553)3.50505759
18lysine catabolic process (GO:0006554)3.50505759
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49534545
20tricarboxylic acid metabolic process (GO:0072350)3.48662216
21regulation of cholesterol homeostasis (GO:2000188)3.45619221
22cellular response to unfolded protein (GO:0034620)3.43525078
23regulation of fatty acid beta-oxidation (GO:0031998)3.39212531
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.34698433
25negative regulation of erythrocyte differentiation (GO:0045647)3.31219962
26macroautophagy (GO:0016236)3.29971340
27ER-nucleus signaling pathway (GO:0006984)3.29675329
282-oxoglutarate metabolic process (GO:0006103)3.27770765
29barbed-end actin filament capping (GO:0051016)3.27390699
30modulation by symbiont of host cellular process (GO:0044068)3.26439260
31peptidyl-proline hydroxylation (GO:0019511)3.22155440
32protein hydroxylation (GO:0018126)3.22058837
33maternal placenta development (GO:0001893)3.21038088
34cellular response to topologically incorrect protein (GO:0035967)3.20875931
35regulation of mammary gland epithelial cell proliferation (GO:0033599)3.18068298
36negative regulation of fatty acid transport (GO:2000192)3.15008513
37sarcomere organization (GO:0045214)3.06427118
38regulation of cholesterol storage (GO:0010885)3.05485652
39positive regulation of fatty acid beta-oxidation (GO:0032000)3.05375213
40pinocytosis (GO:0006907)3.02247840
41stress fiber assembly (GO:0043149)3.01166190
42positive regulation of Cdc42 GTPase activity (GO:0043089)3.01161437
43regulation of fatty acid oxidation (GO:0046320)3.00331368
44COPII vesicle coating (GO:0048208)2.99349511
45modulation by virus of host process (GO:0019054)2.97819024
46activation of Rac GTPase activity (GO:0032863)2.97404344
47apoptotic process involved in morphogenesis (GO:0060561)2.95283514
48basement membrane organization (GO:0071711)2.93144925
49epithelial cell-cell adhesion (GO:0090136)2.92436196
50modulation by virus of host morphology or physiology (GO:0019048)2.88551675
51positive regulation of p38MAPK cascade (GO:1900745)2.88361794
52positive regulation of histone deacetylation (GO:0031065)2.86683703
53vesicle coating (GO:0006901)2.85328494
54proline metabolic process (GO:0006560)2.84685657
55oxaloacetate metabolic process (GO:0006107)2.84390083
56protein heterotrimerization (GO:0070208)2.84365784
57valine metabolic process (GO:0006573)2.81602000
58skin morphogenesis (GO:0043589)2.79837859
59regulation of cholesterol biosynthetic process (GO:0045540)2.79502180
60response to laminar fluid shear stress (GO:0034616)2.78799215
61positive regulation of blood vessel endothelial cell migration (GO:0043536)2.77076536
62response to endoplasmic reticulum stress (GO:0034976)2.76806092
63carnitine shuttle (GO:0006853)2.76189170
64positive regulation of triglyceride biosynthetic process (GO:0010867)2.74528569
65cellular response to nutrient (GO:0031670)2.73878556
66mannose metabolic process (GO:0006013)2.73027928
67positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72713696
68fatty acid transmembrane transport (GO:1902001)2.71158488
69semaphorin-plexin signaling pathway (GO:0071526)2.71152138
70regulation of p38MAPK cascade (GO:1900744)2.69853233
71vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.69746434
72positive regulation of fatty acid oxidation (GO:0046321)2.69690631
73response to unfolded protein (GO:0006986)2.68404462
74NADH metabolic process (GO:0006734)2.67342795
75epithelial cell differentiation involved in prostate gland development (GO:0060742)2.64668920
76aspartate family amino acid catabolic process (GO:0009068)2.63444082
77endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.62336246
78glucose 6-phosphate metabolic process (GO:0051156)2.60851605
79cytoskeletal anchoring at plasma membrane (GO:0007016)2.60453071
80adherens junction assembly (GO:0034333)2.60350048
81positive regulation of glycogen biosynthetic process (GO:0045725)2.60156868
82alpha-linolenic acid metabolic process (GO:0036109)2.59500862
83regulation of extracellular matrix disassembly (GO:0010715)2.59119766
84fatty acid beta-oxidation (GO:0006635)2.59085494
85positive regulation of protein dephosphorylation (GO:0035307)2.58754039
86cell-substrate junction assembly (GO:0007044)2.58581654
87cardiac myofibril assembly (GO:0055003)2.57975901
88vascular endothelial growth factor signaling pathway (GO:0038084)2.56560753
89embryo implantation (GO:0007566)2.56158296
90glucose catabolic process (GO:0006007)2.55660933
91regulation of membrane protein ectodomain proteolysis (GO:0051043)2.55413392
92response to topologically incorrect protein (GO:0035966)2.55195586
93endodermal cell differentiation (GO:0035987)2.54907322
94protein targeting to plasma membrane (GO:0072661)2.54244648
95GDP-mannose metabolic process (GO:0019673)2.53827777
96negative regulation of viral release from host cell (GO:1902187)2.53092061
97positive regulation of receptor recycling (GO:0001921)2.52986082
98tricarboxylic acid cycle (GO:0006099)2.52273284
99negative regulation of necroptotic process (GO:0060546)2.51406329
100insulin-like growth factor receptor signaling pathway (GO:0048009)2.49313349
101cell adhesion mediated by integrin (GO:0033627)2.48747649
102adhesion of symbiont to host (GO:0044406)2.47505315
103activation of MAPKKK activity (GO:0000185)2.45662406
104pentose-phosphate shunt (GO:0006098)2.45266200
105endothelial cell chemotaxis (GO:0035767)2.44579344
1063-UTR-mediated mRNA stabilization (GO:0070935)2.43692561
107cellular response to vitamin (GO:0071295)2.42627776
108planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41956405
109amyloid precursor protein catabolic process (GO:0042987)2.41777003
110polarized epithelial cell differentiation (GO:0030859)2.41766010
111regulation of early endosome to late endosome transport (GO:2000641)2.41648614
112cell migration involved in sprouting angiogenesis (GO:0002042)2.40741311
113cell-cell junction maintenance (GO:0045217)2.40283862
114regulation of tight junction assembly (GO:2000810)2.40101203
115embryonic process involved in female pregnancy (GO:0060136)2.39963316
116focal adhesion assembly (GO:0048041)2.38421172
117cell-substrate adherens junction assembly (GO:0007045)2.38421172
118regulation of NFAT protein import into nucleus (GO:0051532)2.37977615
119regulation of glucose import in response to insulin stimulus (GO:2001273)2.37645060
120collagen fibril organization (GO:0030199)2.36773153
121actin-myosin filament sliding (GO:0033275)2.36429380
122muscle filament sliding (GO:0030049)2.36429380
123negative regulation of lipid transport (GO:0032369)2.36101963
124fatty acid oxidation (GO:0019395)2.35163124
125positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.34662287
126negative regulation of fibrinolysis (GO:0051918)2.33885371
127sulfur amino acid catabolic process (GO:0000098)2.33571705
128UV protection (GO:0009650)2.33360135
129positive regulation of extracellular matrix organization (GO:1903055)2.32635686
130protein localization to endosome (GO:0036010)2.31941592
131fatty acid homeostasis (GO:0055089)2.31742171
132L-alpha-amino acid transmembrane transport (GO:1902475)2.31130223
133protein maturation by protein folding (GO:0022417)2.31029937
134blood vessel endothelial cell migration (GO:0043534)2.31019111
135response to mercury ion (GO:0046689)2.30420774
136regulation of defense response to virus by virus (GO:0050690)2.29015525
137lipid oxidation (GO:0034440)2.28551060
138retrograde transport, endosome to Golgi (GO:0042147)2.28164234
139growth hormone receptor signaling pathway (GO:0060396)2.27997647
140regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.27925494
141hyaluronan catabolic process (GO:0030214)2.27749257
142actin filament bundle organization (GO:0061572)2.27375559
143actin filament bundle assembly (GO:0051017)2.27375559
144negative regulation of skeletal muscle tissue development (GO:0048642)2.27218506
145positive regulation of triglyceride metabolic process (GO:0090208)2.27111906
146peptidyl-glutamic acid carboxylation (GO:0017187)2.26736801
147protein carboxylation (GO:0018214)2.26736801
148negative regulation of potassium ion transmembrane transport (GO:1901380)2.26347906
149positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.24528514
150regulation of cholesterol metabolic process (GO:0090181)2.23816298
151regulation of ARF protein signal transduction (GO:0032012)2.23758471
152regulation of necrotic cell death (GO:0010939)2.23552261
153regulation of superoxide anion generation (GO:0032928)2.22999602
154cortical actin cytoskeleton organization (GO:0030866)2.21031149
155positive regulation of myotube differentiation (GO:0010831)2.20405434
156peptidyl-tyrosine autophosphorylation (GO:0038083)2.19980804
157intracellular estrogen receptor signaling pathway (GO:0030520)2.19615928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.19615133
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.79243716
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.55914673
4CLOCK_20551151_ChIP-Seq_293T_Human2.89585554
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.87954065
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.83049319
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.75395764
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61862265
9LXR_22292898_ChIP-Seq_THP-1_Human2.34797946
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.21116276
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.19973407
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.18846013
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.15790229
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.12066710
15ZNF263_19887448_ChIP-Seq_K562_Human2.06582762
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01665026
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96067101
18* RACK7_27058665_Chip-Seq_MCF-7_Human1.94398166
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89889211
20KDM2B_26808549_Chip-Seq_DND41_Human1.83088348
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80711288
22* MYC_22102868_ChIP-Seq_BL_Human1.77282757
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.76262049
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.73087820
25ATF3_27146783_Chip-Seq_COLON_Human1.72486329
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67109624
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66668995
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66636328
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65654898
30* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61906853
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60307925
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57026119
33TBX20_22328084_ChIP-Seq_HEART_Mouse1.56946682
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.56946682
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55909612
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55211760
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.52604588
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52276045
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.49076327
40TCF7_22412390_ChIP-Seq_EML_Mouse1.48485127
41VDR_21846776_ChIP-Seq_THP-1_Human1.47824864
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43154185
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40478396
44* KDM2B_26808549_Chip-Seq_K562_Human1.39946250
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39058441
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38076383
47* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37689116
48VDR_24763502_ChIP-Seq_THP-1_Human1.36454009
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.35846729
50* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35039842
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34693089
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34590582
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31977357
54P68_20966046_ChIP-Seq_HELA_Human1.31597043
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29534471
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26802012
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26637364
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25270387
59* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25221901
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25104112
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24251666
62* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23904515
63* CREB1_26743006_Chip-Seq_LNCaP_Human1.22892985
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22461950
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21837548
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21441400
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21199378
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20127890
69FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.19794855
70NCOR1_26117541_ChIP-Seq_K562_Human1.18039253
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17337737
72MAF_26560356_Chip-Seq_TH2_Human1.16924416
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15661709
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15466499
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.15397674
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.15037233
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14806435
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13120515
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13056068
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12800789
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12617572
82* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11973893
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11822398
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.11564590
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11201908
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.11134884
87TP53_22127205_ChIP-Seq_IMR90_Human1.11007890
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.10541556
89GATA1_19941826_ChIP-Seq_K562_Human1.10142093
90SMC4_20622854_ChIP-Seq_HELA_Human1.10108531
91BCOR_27268052_Chip-Seq_Bcells_Human1.09782392
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09575391
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09278184
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08820564
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08164458
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07665120
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07417668
98GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06499018
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06426592
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05776944
101MAF_26560356_Chip-Seq_TH1_Human1.05269604
102* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05169818
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.04969234
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04908176
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04863944
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03458280
107MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03261329
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02928268
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01657168
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01566869
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01314000
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00970487
113SPI1_23127762_ChIP-Seq_K562_Human1.00357180
114UTX_26944678_Chip-Seq_JUKART_Human0.99875541
115TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99620471
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99507088
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99455718
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99112331
119BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98944308
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.98896327
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.98759784
122CTCF_21964334_Chip-Seq_Bcells_Human0.98358496
123TP63_22573176_ChIP-Seq_HFKS_Human0.98277424
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.98261583
125FOXA2_19822575_ChIP-Seq_HepG2_Human0.98065020
126BCL6_27268052_Chip-Seq_Bcells_Human0.96594849
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95872723
128* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93210467
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.92807591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.25135200
2MP0008438_abnormal_cutaneous_collagen3.87230878
3MP0005451_abnormal_body_composition3.71401073
4MP0002837_dystrophic_cardiac_calcinosis3.01593139
5MP0008260_abnormal_autophagy2.34890365
6MP0000751_myopathy2.32293196
7MP0000013_abnormal_adipose_tissue2.30800055
8MP0005670_abnormal_white_adipose2.29946068
9MP0009840_abnormal_foam_cell2.16572294
10MP0003566_abnormal_cell_adhesion2.12938299
11MP0005275_abnormal_skin_tensile2.09492850
12MP0004084_abnormal_cardiac_muscle2.04363718
13MP0004272_abnormal_basement_membrane1.93677876
14MP0002877_abnormal_melanocyte_morpholog1.93633221
15MP0005083_abnormal_biliary_tract1.89779242
16MP0003436_decreased_susceptibility_to1.89625777
17MP0005666_abnormal_adipose_tissue1.89267351
18MP0003283_abnormal_digestive_organ1.87444674
19MP0005058_abnormal_lysosome_morphology1.85717665
20MP0000749_muscle_degeneration1.84401167
21MP0003300_gastrointestinal_ulcer1.83878605
22MP0002139_abnormal_hepatobiliary_system1.81987543
23MP0003279_aneurysm1.79811341
24MP0010352_gastrointestinal_tract_polyps1.79493094
25MP0004130_abnormal_muscle_cell1.76260899
26MP0004185_abnormal_adipocyte_glucose1.75579088
27MP0001958_emphysema1.74442973
28MP0003329_amyloid_beta_deposits1.74022155
29MP0005375_adipose_tissue_phenotype1.72647652
30* MP0004087_abnormal_muscle_fiber1.66821908
31MP0003191_abnormal_cellular_cholesterol1.65188974
32MP0003195_calcinosis1.63481102
33MP0000678_abnormal_parathyroid_gland1.62683521
34MP0005360_urolithiasis1.62391887
35* MP0002269_muscular_atrophy1.61671213
36* MP0004858_abnormal_nervous_system1.61033526
37MP0000003_abnormal_adipose_tissue1.58384569
38MP0000747_muscle_weakness1.57721621
39MP0005365_abnormal_bile_salt1.57086815
40MP0005330_cardiomyopathy1.55732846
41MP0003453_abnormal_keratinocyte_physiol1.54306095
42MP0000858_altered_metastatic_potential1.52641184
43MP0004036_abnormal_muscle_relaxation1.51356330
44MP0003172_abnormal_lysosome_physiology1.50325035
45MP0009278_abnormal_bone_marrow1.48647058
46MP0002909_abnormal_adrenal_gland1.47816734
47MP0003252_abnormal_bile_duct1.46210736
48MP0008961_abnormal_basal_metabolism1.45678905
49MP0005076_abnormal_cell_differentiation1.42831294
50MP0005257_abnormal_intraocular_pressure1.41971225
51MP0002896_abnormal_bone_mineralization1.38268996
52MP0005623_abnormal_meninges_morphology1.37859392
53* MP0000750_abnormal_muscle_regeneration1.37299531
54MP0010329_abnormal_lipoprotein_level1.33165155
55MP0005023_abnormal_wound_healing1.31399775
56* MP0000759_abnormal_skeletal_muscle1.28989095
57MP0004947_skin_inflammation1.28716914
58MP0002796_impaired_skin_barrier1.26365367
59MP0001849_ear_inflammation1.24870443
60MP0005167_abnormal_blood-brain_barrier1.23030083
61MP0008775_abnormal_heart_ventricle1.22593555
62MP0003045_fibrosis1.21410367
63MP0006054_spinal_hemorrhage1.21020570
64MP0010630_abnormal_cardiac_muscle1.18669815
65MP0000733_abnormal_muscle_development1.18470693
66MP0009643_abnormal_urine_homeostasis1.17198557
67MP0005501_abnormal_skin_physiology1.17012359
68MP0003075_altered_response_to1.16509908
69MP0003646_muscle_fatigue1.15631809
70MP0002168_other_aberrant_phenotype1.15018092
71MP0000604_amyloidosis1.14352827
72MP0001348_abnormal_lacrimal_gland1.11504861
73MP0010368_abnormal_lymphatic_system1.10657806
74MP0005332_abnormal_amino_acid1.09619567
75MP0001756_abnormal_urination1.09450181
76MP0002249_abnormal_larynx_morphology1.07719868
77MP0005319_abnormal_enzyme/_coenzyme1.07490356
78MP0003091_abnormal_cell_migration1.07455201
79MP0009384_cardiac_valve_regurgitation1.07338149
80MP0002138_abnormal_hepatobiliary_system1.07329567
81MP0003879_abnormal_hair_cell1.07070704
82MP0001915_intracranial_hemorrhage1.06893933
83MP0000609_abnormal_liver_physiology1.06399541
84MP0004043_abnormal_pH_regulation1.05970783
85MP0001666_abnormal_nutrient_absorption1.05453841
86MP0002118_abnormal_lipid_homeostasis1.04633142
87MP0001544_abnormal_cardiovascular_syste1.04206509
88MP0005385_cardiovascular_system_phenoty1.04206509
89MP0005409_darkened_coat_color1.03542382
90MP0004233_abnormal_muscle_weight1.01686037
91MP0005503_abnormal_tendon_morphology1.00854950
92MP0009333_abnormal_splenocyte_physiolog1.00623482
93MP0000537_abnormal_urethra_morphology1.00232833
94MP0005620_abnormal_muscle_contractility1.00025867
95MP0009780_abnormal_chondrocyte_physiolo0.99359638
96MP0005085_abnormal_gallbladder_physiolo0.98731595
97MP0005220_abnormal_exocrine_pancreas0.97080128
98MP0002078_abnormal_glucose_homeostasis0.96783415
99MP0002972_abnormal_cardiac_muscle0.96266900
100MP0003303_peritoneal_inflammation0.96252478
101MP0004510_myositis0.95920885
102* MP0002106_abnormal_muscle_physiology0.94121490
103MP0003123_paternal_imprinting0.93358650
104MP0003221_abnormal_cardiomyocyte_apopto0.93052721
105MP0000767_abnormal_smooth_muscle0.92905578
106MP0001533_abnormal_skeleton_physiology0.92767720
107MP0005621_abnormal_cell_physiology0.92382165
108MP0010234_abnormal_vibrissa_follicle0.91572141
109MP0000681_abnormal_thyroid_gland0.90509228
110MP0006138_congestive_heart_failure0.89671194
111MP0004215_abnormal_myocardial_fiber0.89225834
112MP0002060_abnormal_skin_morphology0.89021359
113MP0004264_abnormal_extraembryonic_tissu0.86562393
114MP0001944_abnormal_pancreas_morphology0.82359304
115MP0000343_altered_response_to0.80843796
116MP0002998_abnormal_bone_remodeling0.80547982
117* MP0005369_muscle_phenotype0.80327145
118MP0008875_abnormal_xenobiotic_pharmacok0.79893875
119MP0005464_abnormal_platelet_physiology0.79331472
120MP0002089_abnormal_postnatal_growth/wei0.78715293
121MP0002971_abnormal_brown_adipose0.78631824
122MP0002295_abnormal_pulmonary_circulatio0.78291209
123MP0003634_abnormal_glial_cell0.77917438
124MP0001542_abnormal_bone_strength0.77711921
125MP0001661_extended_life_span0.76934356
126MP0001730_embryonic_growth_arrest0.76339825
127MP0010030_abnormal_orbit_morphology0.76089560
128MP0005390_skeleton_phenotype0.76020313
129MP0009931_abnormal_skin_appearance0.75820569
130MP0000534_abnormal_ureter_morphology0.75438912
131MP0001243_abnormal_dermal_layer0.75095097
132MP0005508_abnormal_skeleton_morphology0.74306583
133MP0008874_decreased_physiological_sensi0.74127034
134MP0001545_abnormal_hematopoietic_system0.73851853
135MP0005397_hematopoietic_system_phenotyp0.73851853
136MP0001879_abnormal_lymphatic_vessel0.72831267
137MP0000598_abnormal_liver_morphology0.72110686
138MP0003828_pulmonary_edema0.70738270
139MP0004808_abnormal_hematopoietic_stem0.70505527
140MP0003183_abnormal_peptide_metabolism0.69739357
141MP0000266_abnormal_heart_morphology0.69159576
142MP0002128_abnormal_blood_circulation0.69020871
143MP0002970_abnormal_white_adipose0.67935504
144MP0002332_abnormal_exercise_endurance0.67806416
145MP0009672_abnormal_birth_weight0.65886987
146MP0003795_abnormal_bone_structure0.64883541
147MP0003942_abnormal_urinary_system0.64381569
148MP0001216_abnormal_epidermal_layer0.62075834
149MP0003448_altered_tumor_morphology0.61254806
150MP0001873_stomach_inflammation0.60773741
151MP0002113_abnormal_skeleton_development0.60534334

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.45501749
2Premature rupture of membranes (HP:0001788)3.96378134
3Cerebral aneurysm (HP:0004944)3.81668735
4Increased connective tissue (HP:0009025)3.50029908
5Hyperacusis (HP:0010780)3.27923088
6Asymmetric septal hypertrophy (HP:0001670)3.16548357
7Type 1 muscle fiber predominance (HP:0003803)3.04726412
8Myoglobinuria (HP:0002913)3.00532604
9Shallow orbits (HP:0000586)2.90606202
10Long toe (HP:0010511)2.89163923
11Hypoglycemic coma (HP:0001325)2.88163564
12Broad metatarsal (HP:0001783)2.88148931
13Ankle contracture (HP:0006466)2.82368938
14Difficulty climbing stairs (HP:0003551)2.77605481
15Distal lower limb amyotrophy (HP:0008944)2.76619467
16Exercise-induced muscle cramps (HP:0003710)2.70669196
17Distal lower limb muscle weakness (HP:0009053)2.70268801
18Upper limb amyotrophy (HP:0009129)2.67856435
19Distal upper limb amyotrophy (HP:0007149)2.67856435
20Muscle fiber splitting (HP:0003555)2.66555707
21Flat acetabular roof (HP:0003180)2.65180233
22Hyporeflexia of lower limbs (HP:0002600)2.63412966
23Centrally nucleated skeletal muscle fibers (HP:0003687)2.62180321
24Ketoacidosis (HP:0001993)2.61829850
25Aneurysm (HP:0002617)2.60657206
26Exercise-induced myalgia (HP:0003738)2.54934095
27Cervical subluxation (HP:0003308)2.52915645
28Hand muscle atrophy (HP:0009130)2.52528549
29Increased variability in muscle fiber diameter (HP:0003557)2.50203900
30Peritonitis (HP:0002586)2.46379793
31Sudden death (HP:0001699)2.45829075
32Difficulty running (HP:0009046)2.44304212
33Mildly elevated creatine phosphokinase (HP:0008180)2.44111780
34Lymphangioma (HP:0100764)2.37579002
35Right ventricular cardiomyopathy (HP:0011663)2.36028343
36Myopathic facies (HP:0002058)2.35759594
37Mitral valve prolapse (HP:0001634)2.35454595
38Deep venous thrombosis (HP:0002625)2.31730032
39Vertebral compression fractures (HP:0002953)2.31342788
40Urinary glycosaminoglycan excretion (HP:0003541)2.29436616
41Mucopolysacchariduria (HP:0008155)2.29436616
42Dysostosis multiplex (HP:0000943)2.27076997
43Disproportionate tall stature (HP:0001519)2.26753620
44Bladder diverticulum (HP:0000015)2.26626044
45Ketosis (HP:0001946)2.26018097
46Abnormality of the Achilles tendon (HP:0005109)2.25326586
47Achilles tendon contracture (HP:0001771)2.25112305
48Aortic dissection (HP:0002647)2.24354962
49Broad face (HP:0000283)2.24063438
50Axonal loss (HP:0003447)2.23754722
51Polycythemia (HP:0001901)2.23727950
52Atrophic scars (HP:0001075)2.23639903
53Insomnia (HP:0100785)2.23153844
54Gout (HP:0001997)2.22771016
55Mitral regurgitation (HP:0001653)2.22568527
56Abnormality of skeletal muscle fiber size (HP:0012084)2.21026809
57Aortic aneurysm (HP:0004942)2.20896410
58Xanthomatosis (HP:0000991)2.20643236
59Dilatation of the ascending aorta (HP:0005111)2.19477612
60Abnormality of the distal phalanges of the toes (HP:0010182)2.16062827
61Hyperinsulinemic hypoglycemia (HP:0000825)2.15197482
62Short nail (HP:0001799)2.13883401
63Ventricular tachycardia (HP:0004756)2.13589736
64Thin bony cortex (HP:0002753)2.13025275
65Turricephaly (HP:0000262)2.12822303
66Late onset (HP:0003584)2.12806649
67Abnormality of polysaccharide metabolism (HP:0011012)2.12602870
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12602870
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12602870
70Scapular winging (HP:0003691)2.12031863
71Hyperglycemia (HP:0003074)2.11445189
72Spinal rigidity (HP:0003306)2.08409416
73Long palpebral fissure (HP:0000637)2.08191378
74Elbow flexion contracture (HP:0002987)2.08026699
75Stridor (HP:0010307)2.04489443
76Cerebral inclusion bodies (HP:0100314)2.03373980
77Back pain (HP:0003418)1.99727709
78Blue sclerae (HP:0000592)1.99685717
79Rhabdomyolysis (HP:0003201)1.97000536
80Obstructive sleep apnea (HP:0002870)1.96964310
81Fragile skin (HP:0001030)1.95472322
82Abnormality of carpal bone ossification (HP:0006257)1.93591357
83Skin nodule (HP:0200036)1.92878408
84Hemorrhage of the eye (HP:0011885)1.92016246
85Cholecystitis (HP:0001082)1.92004785
86Abnormal gallbladder physiology (HP:0012438)1.92004785
87Trismus (HP:0000211)1.91200562
88Genu recurvatum (HP:0002816)1.90516907
89Bundle branch block (HP:0011710)1.90046257
90Lower limb amyotrophy (HP:0007210)1.89371185
91Enlarged penis (HP:0000040)1.89356895
92Myocardial infarction (HP:0001658)1.88942648
93EMG: myopathic abnormalities (HP:0003458)1.87249874
94Hyperparathyroidism (HP:0000843)1.86550448
95Lipoatrophy (HP:0100578)1.85237578
96Abnormality of the acetabulum (HP:0003170)1.84689656
97Premature skin wrinkling (HP:0100678)1.84374514
98Soft skin (HP:0000977)1.84339517
99Abnormal ossification of hand bones (HP:0005921)1.83425124
100Abnormal cartilage morphology (HP:0002763)1.80533064
101Hypoalphalipoproteinemia (HP:0003233)1.80393000
102Metaphyseal cupping (HP:0003021)1.79402121
103J-shaped sella turcica (HP:0002680)1.79396852
104Abnormality of glycolipid metabolism (HP:0010969)1.78990039
105Abnormality of liposaccharide metabolism (HP:0010968)1.78990039
106Abnormality of glycosphingolipid metabolism (HP:0004343)1.78990039
107Ragged-red muscle fibers (HP:0003200)1.78347894
108Upper motor neuron abnormality (HP:0002127)1.78194040
109Ulnar deviation of the wrist (HP:0003049)1.77847306
110Limb-girdle muscle atrophy (HP:0003797)1.77186180
111Vascular tortuosity (HP:0004948)1.76700310
112Coxa vara (HP:0002812)1.76475961
113Abnormality of the thoracic spine (HP:0100711)1.75583989
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.74951310
115Osteolytic defects of the hand bones (HP:0009699)1.74951310
116Abnormality of the left ventricular outflow tract (HP:0011103)1.74567444
117Subaortic stenosis (HP:0001682)1.74567444
118Growth hormone excess (HP:0000845)1.74210644
119Frequent falls (HP:0002359)1.74022546
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73881417
121Asymmetry of the thorax (HP:0001555)1.72501798
122Striae distensae (HP:0001065)1.72363271
123Global brain atrophy (HP:0002283)1.70924327
124Bulbar palsy (HP:0001283)1.70184636
125Reticulocytosis (HP:0001923)1.69920442
126Hypercortisolism (HP:0001578)1.68358162
127Ulnar bowing (HP:0003031)1.68155701
128Cellulitis (HP:0100658)1.68126429
129Ovoid vertebral bodies (HP:0003300)1.67902174
130Slender build (HP:0001533)1.67737992
131Abnormality of dentin (HP:0010299)1.67684836
132Joint laxity (HP:0001388)1.67651151
133Generalized amyotrophy (HP:0003700)1.67269482
134Insulin-resistant diabetes mellitus (HP:0000831)1.66999218
135Wormian bones (HP:0002645)1.66874846
136Hypoglycemic seizures (HP:0002173)1.66475504
137Neurofibrillary tangles (HP:0002185)1.66190227
138Ectopia lentis (HP:0001083)1.65403449
139Arterial tortuosity (HP:0005116)1.64789743
140EMG: neuropathic changes (HP:0003445)1.64486371
141Bowed forearm bones (HP:0003956)1.63602346
142Bowing of the arm (HP:0006488)1.63602346
143Round ear (HP:0100830)1.63564911
144Segmental peripheral demyelination/remyelination (HP:0003481)1.63179261
145Abnormality of the distal phalanx of the thumb (HP:0009617)1.62824567
146Patellar dislocation (HP:0002999)1.62646349
147Abnormality of the calf musculature (HP:0001430)1.62562096
148Insulin resistance (HP:0000855)1.62133589
149Radial bowing (HP:0002986)1.62111205
150Congenital glaucoma (HP:0001087)1.61550900
151Abnormality of purine metabolism (HP:0004352)1.61458978
152Complement deficiency (HP:0004431)1.60951145
153Joint stiffness (HP:0001387)1.60643555
154Muscle stiffness (HP:0003552)1.60541752
155Bowel diverticulosis (HP:0005222)1.60368119
156Biconcave vertebral bodies (HP:0004586)1.57363325
157Mitral stenosis (HP:0001718)1.57344607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.28604730
2ERN14.01970109
3PKN23.80848870
4TTN3.68622821
5PRPF4B3.08667694
6IRAK32.97882822
7SMG12.86058651
8NME22.58941449
9SIK12.57489516
10RIPK12.45241788
11PDGFRA2.22350638
12PTK62.22167188
13BCKDK2.04962655
14EEF2K1.95538239
15ARAF1.80641143
16SCYL21.77939169
17TESK21.71367354
18TBK11.62142398
19MAP3K101.61881739
20FLT31.56360177
21DDR21.55274948
22PTK21.45787999
23PRKD21.44790761
24CAMK1D1.41800160
25PIM21.39205478
26MAP2K31.38573345
27LRRK21.35788709
28FGFR41.34607826
29NEK11.27064319
30BMX1.23718316
31PHKG21.20417535
32PHKG11.20417535
33LATS21.19517702
34LMTK21.17852080
35LATS11.17806297
36PAK41.17504367
37TAOK11.17411767
38RIPK41.15183647
39TESK11.12924266
40CAMK1G1.08717944
41EPHB11.07905201
42DMPK1.05507363
43TGFBR21.01908978
44MST1R0.98947239
45MET0.98347027
46PDK40.98305595
47PDK30.98305595
48KSR20.97363537
49RPS6KA40.95501721
50MTOR0.95491401
51KDR0.95175254
52IRAK20.95097913
53ICK0.94745150
54NTRK10.92391965
55FER0.91278843
56MAP3K30.91123664
57BRAF0.90586114
58PAK30.88640004
59RET0.85427575
60PAK20.84175962
61MAP3K110.83918600
62CAMKK10.83843702
63MAP3K10.83394071
64JAK10.83338057
65PRKD10.82965775
66MAP3K70.78365331
67HIPK20.76863923
68MAP3K130.75726275
69STK380.75501986
70EPHA30.74790386
71PRKD30.74716039
72IRAK40.72883781
73DAPK30.72834367
74MAP4K10.70579899
75ILK0.69885488
76CDC42BPA0.69560262
77MAPKAPK30.67448720
78EPHA20.67212446
79MOS0.67042718
80EPHB20.65200448
81WNK40.64834380
82INSRR0.64578225
83PRKCH0.64417063
84MAP2K10.64068845
85PIK3CG0.63905788
86PDK20.63471604
87ALK0.62633143
88PDGFRB0.60947347
89ZAP700.60796549
90MAP3K60.60560202
91MAPK110.60133216
92RPS6KL10.59908617
93TNK20.59580721
94MAP3K20.59068782
95PDPK10.57987351
96RPS6KA20.57430001
97CAMKK20.57363631
98OBSCN0.56285700
99MAPK120.55960858
100JAK20.55424781
101DYRK1B0.55423143
102MAP2K20.55085409
103MYLK0.52378540
104ABL20.51777251
105MAP3K80.49640828
106CDK70.48404273
107PRKAA10.47901959
108PDK10.47038687
109GRK60.46997709
110PRKCI0.46764433
111TAOK20.46587807
112RAF10.46333362
113LIMK10.43441736
114PRKG20.42042548
115AKT20.41583311
116ROCK10.41110729
117RPS6KB20.40488671
118NEK90.39564920
119TYK20.39254321
120PAK60.39127265
121FGFR10.38752721
122CAMK2G0.38347147
123SIK20.38268968
124MARK20.37142357
125RPS6KA60.36621593
126PAK10.36523224
127TAOK30.35784977
128CDK120.35712370
129AURKA0.35216069
130DAPK20.35123363
131CAMK40.34262377
132CDK11A0.33137580
133PASK0.33087185
134STK100.31380422
135RPS6KC10.31352156
136SIK30.31261683
137JAK30.30284024
138CDK150.29606266

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.99768064
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.83362494
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.70998517
4Fatty acid degradation_Homo sapiens_hsa000712.20888057
5Nitrogen metabolism_Homo sapiens_hsa009102.04358396
6Maturity onset diabetes of the young_Homo sapiens_hsa049501.95244104
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90609213
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72310870
9Carbon metabolism_Homo sapiens_hsa012001.66977851
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64977642
11Arginine biosynthesis_Homo sapiens_hsa002201.56611584
12Non-small cell lung cancer_Homo sapiens_hsa052231.54501013
13PPAR signaling pathway_Homo sapiens_hsa033201.54315350
14Insulin resistance_Homo sapiens_hsa049311.53999755
15Propanoate metabolism_Homo sapiens_hsa006401.52678143
16Tryptophan metabolism_Homo sapiens_hsa003801.49356355
17Fatty acid metabolism_Homo sapiens_hsa012121.43503625
18Caffeine metabolism_Homo sapiens_hsa002321.39356249
19Focal adhesion_Homo sapiens_hsa045101.38289004
20Dilated cardiomyopathy_Homo sapiens_hsa054141.37410545
21Notch signaling pathway_Homo sapiens_hsa043301.35230896
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34938851
23Biosynthesis of amino acids_Homo sapiens_hsa012301.34424658
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.30143215
25Starch and sucrose metabolism_Homo sapiens_hsa005001.28908488
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28478593
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26638217
28Pyruvate metabolism_Homo sapiens_hsa006201.26519891
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26491463
30Selenocompound metabolism_Homo sapiens_hsa004501.26305528
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24125000
32Endometrial cancer_Homo sapiens_hsa052131.23616576
33Lysosome_Homo sapiens_hsa041421.23071609
34ECM-receptor interaction_Homo sapiens_hsa045121.21319664
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.21097983
36Thyroid cancer_Homo sapiens_hsa052161.20136714
37Vibrio cholerae infection_Homo sapiens_hsa051101.20113784
38Galactose metabolism_Homo sapiens_hsa000521.18952610
39Fatty acid biosynthesis_Homo sapiens_hsa000611.17228768
40Protein digestion and absorption_Homo sapiens_hsa049741.16743877
41Amoebiasis_Homo sapiens_hsa051461.15836139
42Butanoate metabolism_Homo sapiens_hsa006501.14941510
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13332101
44Lysine degradation_Homo sapiens_hsa003101.13311994
45Fat digestion and absorption_Homo sapiens_hsa049751.12353553
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.08716177
47Bladder cancer_Homo sapiens_hsa052191.08447647
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.07663753
49Other glycan degradation_Homo sapiens_hsa005111.06873418
50Type II diabetes mellitus_Homo sapiens_hsa049301.06489143
51Renal cell carcinoma_Homo sapiens_hsa052111.06057651
52Insulin signaling pathway_Homo sapiens_hsa049101.04773784
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04153541
54B cell receptor signaling pathway_Homo sapiens_hsa046621.04117933
55ErbB signaling pathway_Homo sapiens_hsa040121.01612302
56Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01007164
57Bile secretion_Homo sapiens_hsa049760.99697240
58Proteoglycans in cancer_Homo sapiens_hsa052050.99479976
59GnRH signaling pathway_Homo sapiens_hsa049120.99411138
60AMPK signaling pathway_Homo sapiens_hsa041520.97877546
61Hepatitis C_Homo sapiens_hsa051600.96742723
62Osteoclast differentiation_Homo sapiens_hsa043800.96240493
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96085455
64Shigellosis_Homo sapiens_hsa051310.95775208
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94876714
66Glucagon signaling pathway_Homo sapiens_hsa049220.94656918
67Salmonella infection_Homo sapiens_hsa051320.93479114
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88843616
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88636505
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87798642
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87595776
72Chronic myeloid leukemia_Homo sapiens_hsa052200.87150203
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87092925
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86586213
75Complement and coagulation cascades_Homo sapiens_hsa046100.86194557
76Apoptosis_Homo sapiens_hsa042100.85694617
77TNF signaling pathway_Homo sapiens_hsa046680.85222493
78Hepatitis B_Homo sapiens_hsa051610.82870993
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.81859168
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80112939
81mTOR signaling pathway_Homo sapiens_hsa041500.79967039
82N-Glycan biosynthesis_Homo sapiens_hsa005100.78366526
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77603946
84Glycerolipid metabolism_Homo sapiens_hsa005610.77169723
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76969404
86Prostate cancer_Homo sapiens_hsa052150.75528990
87Fructose and mannose metabolism_Homo sapiens_hsa000510.73131278
88Prion diseases_Homo sapiens_hsa050200.72108769
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71692388
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.70618534
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69377940
92beta-Alanine metabolism_Homo sapiens_hsa004100.68957646
93Adherens junction_Homo sapiens_hsa045200.68640291
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68548516
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67897292
96Choline metabolism in cancer_Homo sapiens_hsa052310.67804686
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65344845
98Inositol phosphate metabolism_Homo sapiens_hsa005620.65184930
99Influenza A_Homo sapiens_hsa051640.62715015
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60901330
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60690270
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59985838
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.59913804
104Synaptic vesicle cycle_Homo sapiens_hsa047210.59873757
105Small cell lung cancer_Homo sapiens_hsa052220.59633497
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.59119868
107Viral carcinogenesis_Homo sapiens_hsa052030.58433648
108HIF-1 signaling pathway_Homo sapiens_hsa040660.57454520
109HTLV-I infection_Homo sapiens_hsa051660.56999413
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56181885
111Toxoplasmosis_Homo sapiens_hsa051450.55705307
112Long-term potentiation_Homo sapiens_hsa047200.54694414
113Insulin secretion_Homo sapiens_hsa049110.53776658
114VEGF signaling pathway_Homo sapiens_hsa043700.53150551
115Pentose phosphate pathway_Homo sapiens_hsa000300.52866470
116Colorectal cancer_Homo sapiens_hsa052100.52729125
117Phenylalanine metabolism_Homo sapiens_hsa003600.52116063
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51876336
119Tuberculosis_Homo sapiens_hsa051520.51793263
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51460070
121Arginine and proline metabolism_Homo sapiens_hsa003300.49828650
122ABC transporters_Homo sapiens_hsa020100.49758205
123Malaria_Homo sapiens_hsa051440.49513577
124Peroxisome_Homo sapiens_hsa041460.49474802
125Viral myocarditis_Homo sapiens_hsa054160.48727218
126Sulfur relay system_Homo sapiens_hsa041220.48164454
127Leishmaniasis_Homo sapiens_hsa051400.48156930
128Prolactin signaling pathway_Homo sapiens_hsa049170.47945510
129Pertussis_Homo sapiens_hsa051330.47833618
130Staphylococcus aureus infection_Homo sapiens_hsa051500.47825444
131Estrogen signaling pathway_Homo sapiens_hsa049150.47342671
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46578666
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46398943
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.45820662
135Acute myeloid leukemia_Homo sapiens_hsa052210.45352611
136Glioma_Homo sapiens_hsa052140.44550653
137MicroRNAs in cancer_Homo sapiens_hsa052060.44439923
138Endocytosis_Homo sapiens_hsa041440.44384670
139Pancreatic cancer_Homo sapiens_hsa052120.44274072
140Legionellosis_Homo sapiens_hsa051340.43564752
141Sulfur metabolism_Homo sapiens_hsa009200.43398744
142Thyroid hormone synthesis_Homo sapiens_hsa049180.42254856
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41425045

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