SCYL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)4.22119287
2regulation of response to tumor cell (GO:0002834)4.08994429
3positive regulation of response to tumor cell (GO:0002836)4.08994429
4positive regulation of immune response to tumor cell (GO:0002839)4.08994429
5regulation of immune response to tumor cell (GO:0002837)4.08994429
6urea cycle (GO:0000050)3.99071853
7urea metabolic process (GO:0019627)3.99071853
8pore complex assembly (GO:0046931)3.94649202
9growth hormone receptor signaling pathway (GO:0060396)3.80341286
10phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.79879821
11positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.73737573
12positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.73737573
13positive regulation of mitotic sister chromatid separation (GO:1901970)3.73737573
14necroptotic process (GO:0070266)3.71978026
15regulation of cAMP-dependent protein kinase activity (GO:2000479)3.63523226
16proline biosynthetic process (GO:0006561)3.55131987
17regulation of RNA export from nucleus (GO:0046831)3.52571748
18nitrogen cycle metabolic process (GO:0071941)3.41728616
19monoubiquitinated protein deubiquitination (GO:0035520)3.38812595
20cysteine metabolic process (GO:0006534)3.36351154
21embryonic retina morphogenesis in camera-type eye (GO:0060059)3.32463963
22negative regulation of neurotransmitter secretion (GO:0046929)3.27402400
23COPII vesicle coating (GO:0048208)3.23894888
24histone H2A monoubiquitination (GO:0035518)3.23791260
25mitotic sister chromatid cohesion (GO:0007064)3.22855933
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.21970484
27nerve growth factor signaling pathway (GO:0038180)3.20906800
28Rap protein signal transduction (GO:0032486)3.18245914
29cellular response to growth hormone stimulus (GO:0071378)3.18002612
30protein localization to microtubule (GO:0035372)3.13325566
31L-phenylalanine catabolic process (GO:0006559)3.12101962
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.12101962
33chondrocyte development (GO:0002063)3.09127385
34regulation of nucleobase-containing compound transport (GO:0032239)3.07304506
35acrosome assembly (GO:0001675)3.05843264
36negative regulation of cholesterol transport (GO:0032375)3.05830465
37negative regulation of sterol transport (GO:0032372)3.05830465
38negative regulation of interleukin-17 production (GO:0032700)3.05464941
39negative regulation of keratinocyte proliferation (GO:0010839)3.05136149
40negative regulation of fibrinolysis (GO:0051918)3.04980509
41alpha-linolenic acid metabolic process (GO:0036109)3.00735005
42positive regulation of fatty acid beta-oxidation (GO:0032000)3.00472073
43NLS-bearing protein import into nucleus (GO:0006607)3.00393755
44regulation of cholesterol homeostasis (GO:2000188)2.99121595
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.99071296
46L-phenylalanine metabolic process (GO:0006558)2.99071296
47necrotic cell death (GO:0070265)2.98900353
48regulation of Rac protein signal transduction (GO:0035020)2.98641141
49regulation of histone H3-K9 methylation (GO:0051570)2.96604389
50nuclear pore complex assembly (GO:0051292)2.96427164
51phospholipid homeostasis (GO:0055091)2.92515191
52protein targeting to Golgi (GO:0000042)2.88056160
53drug catabolic process (GO:0042737)2.86027265
54retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84594069
55sulfur amino acid catabolic process (GO:0000098)2.83586962
56protein carboxylation (GO:0018214)2.82631880
57peptidyl-glutamic acid carboxylation (GO:0017187)2.82631880
58lysine metabolic process (GO:0006553)2.82147956
59lysine catabolic process (GO:0006554)2.82147956
60iron ion import (GO:0097286)2.82139682
61protein localization to chromosome, centromeric region (GO:0071459)2.81848537
62regulation of fatty acid beta-oxidation (GO:0031998)2.81740259
63cellular response to ethanol (GO:0071361)2.80207981
64complement activation, alternative pathway (GO:0006957)2.79903040
65programmed necrotic cell death (GO:0097300)2.79796132
66interkinetic nuclear migration (GO:0022027)2.78880468
67regulation of NFAT protein import into nucleus (GO:0051532)2.77956382
68clathrin coat assembly (GO:0048268)2.77650008
69early endosome to late endosome transport (GO:0045022)2.76908052
70negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.76215777
71kynurenine metabolic process (GO:0070189)2.76157604
72homocysteine metabolic process (GO:0050667)2.74470200
73hippo signaling (GO:0035329)2.74081055
74regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.73392164
75aromatic amino acid family catabolic process (GO:0009074)2.73171445
76protein-lipid complex assembly (GO:0065005)2.73085686
77megakaryocyte development (GO:0035855)2.73002731
78insulin-like growth factor receptor signaling pathway (GO:0048009)2.72598813
79establishment of protein localization to Golgi (GO:0072600)2.72478321
80epithelial cell-cell adhesion (GO:0090136)2.71641106
81regulation of protein activation cascade (GO:2000257)2.70578432
82vesicle coating (GO:0006901)2.67865561
83pre-miRNA processing (GO:0031054)2.67461255
84dicarboxylic acid biosynthetic process (GO:0043650)2.66625372
85hepatocyte apoptotic process (GO:0097284)2.66088939
86negative regulation of lipid transport (GO:0032369)2.66031589
87plasma lipoprotein particle assembly (GO:0034377)2.66006028
88serine family amino acid catabolic process (GO:0009071)2.64656049
89histone H3-K36 demethylation (GO:0070544)2.64204538
90positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64132737
91negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.63589524
92regulation of sister chromatid cohesion (GO:0007063)2.61040457
93cell adhesion mediated by integrin (GO:0033627)2.60322977
94positive regulation of lipid catabolic process (GO:0050996)2.60234387
95high-density lipoprotein particle remodeling (GO:0034375)2.60116406
96reverse cholesterol transport (GO:0043691)2.59770961
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56626122
98protein localization to endosome (GO:0036010)2.56584029
99urate metabolic process (GO:0046415)2.55880826
100glycoprotein catabolic process (GO:0006516)2.54707956
101interleukin-6-mediated signaling pathway (GO:0070102)2.54576366
102protein localization to microtubule cytoskeleton (GO:0072698)2.54347520
103mesodermal cell differentiation (GO:0048333)2.54297686
104embryonic process involved in female pregnancy (GO:0060136)2.54143737
105poly(A)+ mRNA export from nucleus (GO:0016973)2.53502879
106regulation of triglyceride catabolic process (GO:0010896)2.53166496
107histone lysine demethylation (GO:0070076)2.52580740
108phospholipid efflux (GO:0033700)2.52153508
109response to growth hormone (GO:0060416)2.52108716
110mitotic chromosome condensation (GO:0007076)2.51845063
111regulation of complement activation (GO:0030449)2.51667696
112protein localization to kinetochore (GO:0034501)2.51656767
113lymphoid progenitor cell differentiation (GO:0002320)2.51597474
114sphingosine metabolic process (GO:0006670)2.50703981
115regulation of fibrinolysis (GO:0051917)2.49936997
116corticosteroid receptor signaling pathway (GO:0031958)2.49427497
117plasma lipoprotein particle clearance (GO:0034381)2.48549254
118tryptophan metabolic process (GO:0006568)2.46970716
119regulation of Golgi to plasma membrane protein transport (GO:0042996)2.45799777
120definitive hemopoiesis (GO:0060216)2.43349394
121positive regulation of glycolytic process (GO:0045821)2.43286551
122protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.43011438
123regulation of transforming growth factor beta2 production (GO:0032909)2.42956631
124positive regulation of protein autophosphorylation (GO:0031954)2.42440732
125positive regulation of chromosome segregation (GO:0051984)2.40471626
126protein targeting to vacuole (GO:0006623)2.39840733
127protein targeting to lysosome (GO:0006622)2.39840733
128establishment of protein localization to vacuole (GO:0072666)2.39840733
129epoxygenase P450 pathway (GO:0019373)2.39699936
130regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.38277218
131skin morphogenesis (GO:0043589)2.38234389
132tryptophan catabolic process (GO:0006569)2.38066945
133indole-containing compound catabolic process (GO:0042436)2.38066945
134indolalkylamine catabolic process (GO:0046218)2.38066945
135germ cell migration (GO:0008354)2.37563686
136viral entry into host cell (GO:0046718)2.37484935
137macroautophagy (GO:0016236)2.37268868
138regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.36931913
139regulation of bile acid biosynthetic process (GO:0070857)2.36670474
140bile acid biosynthetic process (GO:0006699)2.36029416
141thrombin receptor signaling pathway (GO:0070493)2.35176035
142cholesterol efflux (GO:0033344)2.34979908
143nuclear pore organization (GO:0006999)2.34978625
144positive regulation of hormone biosynthetic process (GO:0046886)2.34928008
145negative regulation of histone methylation (GO:0031061)2.34916805
146regulation of transforming growth factor beta production (GO:0071634)2.34777441
147cytokine production involved in immune response (GO:0002367)2.34693363
148ether lipid metabolic process (GO:0046485)2.33796966
149low-density lipoprotein particle clearance (GO:0034383)2.33613719
150histone H3-K9 demethylation (GO:0033169)2.33445858
151histone demethylation (GO:0016577)2.33391602
152dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.33300694
153regulation of protein export from nucleus (GO:0046825)2.32198823
154bile acid metabolic process (GO:0008206)2.31716101
155response to lipoprotein particle (GO:0055094)2.31135604
156regulation of membrane protein ectodomain proteolysis (GO:0051043)2.31094062
157localization within membrane (GO:0051668)2.29301968
158membrane budding (GO:0006900)2.28965797
159magnesium ion transport (GO:0015693)2.28844148
160fibroblast migration (GO:0010761)2.28740930
161midgut development (GO:0007494)2.27673055
162triglyceride homeostasis (GO:0070328)2.27471305
163acylglycerol homeostasis (GO:0055090)2.27471305
164glutamate metabolic process (GO:0006536)2.27337757
165gastrulation with mouth forming second (GO:0001702)2.26451186
166negative regulation of DNA repair (GO:0045738)2.25706138
167tyrosine metabolic process (GO:0006570)2.25618085
168positive regulation of insulin receptor signaling pathway (GO:0046628)2.25617385
169microtubule anchoring (GO:0034453)2.25476821
170morphogenesis of an epithelial sheet (GO:0002011)2.25417568
171regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.25337133
172glucocorticoid receptor signaling pathway (GO:0042921)2.24740652
173stress fiber assembly (GO:0043149)2.23996398
174lipoprotein metabolic process (GO:0042157)2.23641580
175bile acid and bile salt transport (GO:0015721)2.23326069
176single strand break repair (GO:0000012)2.22412123
177regulation of histone H3-K27 methylation (GO:0061085)2.20283654
178negative regulation of NF-kappaB import into nucleus (GO:0042347)2.20110008
179Golgi to endosome transport (GO:0006895)2.19885953
180negative regulation of fibroblast apoptotic process (GO:2000270)2.19521084
181protein localization to chromosome (GO:0034502)2.19499100
182cellular response to fluid shear stress (GO:0071498)2.18042597
183cellular protein complex localization (GO:0034629)2.18019784
184myelin assembly (GO:0032288)2.17453910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.11953090
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.78746996
3GATA1_22025678_ChIP-Seq_K562_Human3.54517653
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.27532459
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.27434284
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.02926216
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.00564941
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.93108504
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.83172738
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.79708090
11* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.66879430
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.64277866
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.46484737
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.25957999
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.20075940
16CLOCK_20551151_ChIP-Seq_293T_Human2.17060521
17FOXO3_23340844_ChIP-Seq_DLD1_Human2.03803833
18NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.02880790
19NRF2_20460467_ChIP-Seq_MEFs_Mouse2.02880790
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94384481
21TAF15_26573619_Chip-Seq_HEK293_Human1.78131787
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76697443
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76012771
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.75656699
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70209046
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.69461810
27FUS_26573619_Chip-Seq_HEK293_Human1.69411124
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69188728
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.67444625
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65111486
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64630867
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64128040
33FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.60352521
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59396899
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58434914
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55631123
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54694199
38FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.54466767
39IGF1R_20145208_ChIP-Seq_DFB_Human1.53665874
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51789978
41EWS_26573619_Chip-Seq_HEK293_Human1.50086431
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.49770999
43GBX2_23144817_ChIP-Seq_PC3_Human1.48809557
44GATA6_25053715_ChIP-Seq_YYC3_Human1.48231960
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47961146
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47400885
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47140343
48TP53_16413492_ChIP-PET_HCT116_Human1.45825501
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45733561
50AR_21909140_ChIP-Seq_LNCAP_Human1.44782275
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44105868
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.41793353
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41553945
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38652759
55ER_23166858_ChIP-Seq_MCF-7_Human1.38513666
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38327948
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.37343129
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35430424
59BRD4_25478319_ChIP-Seq_HGPS_Human1.35246544
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33779173
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33412748
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32988215
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32436180
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.32281640
65SMAD4_21799915_ChIP-Seq_A2780_Human1.30054112
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.29523370
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28961534
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.27553283
69GATA4_25053715_ChIP-Seq_YYC3_Human1.26866266
70P300_19829295_ChIP-Seq_ESCs_Human1.26180868
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25090688
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.25063543
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24964864
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.23884514
75TCF7_22412390_ChIP-Seq_EML_Mouse1.23750373
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23225060
77P53_22387025_ChIP-Seq_ESCs_Mouse1.20299652
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20245378
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19956243
80AHR_22903824_ChIP-Seq_MCF-7_Human1.19512462
81* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19187821
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18366980
83* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17485172
84E2F7_22180533_ChIP-Seq_HELA_Human1.16281802
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16158610
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15670372
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15670372
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15414872
89CJUN_26792858_Chip-Seq_BT549_Human1.15036673
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12379059
91ZNF263_19887448_ChIP-Seq_K562_Human1.11092558
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10967719
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10703736
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10532982
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10022273
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.09764848
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08595406
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07330655
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07153646
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.07086088
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07040394
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.06050061
103ATF3_27146783_Chip-Seq_COLON_Human1.06039672
104ELK1_19687146_ChIP-ChIP_HELA_Human1.06029760
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05794756
106HNF4A_19822575_ChIP-Seq_HepG2_Human1.05512651
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05045030
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.04875599
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04522532
110ISL1_27105846_Chip-Seq_CPCs_Mouse1.04047085
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.03884476
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03630025
113P300_18555785_Chip-Seq_ESCs_Mouse1.03622607
114STAT3_23295773_ChIP-Seq_U87_Human1.03547557
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03109583
116VDR_24787735_ChIP-Seq_THP-1_Human1.02710967
117SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01972630
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01163335
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.00876993
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00335049
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00275200
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.00268225
123SOX2_18555785_Chip-Seq_ESCs_Mouse0.99938432
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.99816447
125* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99716781
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99225576
127E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98732771
128RUNX1_27514584_Chip-Seq_MCF-7_Human0.98570144
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98391412
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98179612
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98107706
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98064685
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97896861
134CDX2_22108803_ChIP-Seq_LS180_Human0.97795595
135ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97592992
136RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97418501
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.97072864
138TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96999217
139RXR_22108803_ChIP-Seq_LS180_Human0.95889820
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95258946
141TP53_18474530_ChIP-ChIP_U2OS_Human0.95102263
142OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94891187
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94340120
144FOXA1_25552417_ChIP-Seq_VCAP_Human0.94337229
145NMYC_18555785_Chip-Seq_ESCs_Mouse0.94081051
146KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93732306
147KDM2B_26808549_Chip-Seq_DND41_Human0.93574405
148TP63_23658742_ChIP-Seq_EP156T_Human0.93257963
149* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91565026
150AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91543427
151ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91485600
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90495253
153MYC_22102868_ChIP-Seq_BL_Human0.90170276
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89416767
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89102229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.90243373
2MP0002139_abnormal_hepatobiliary_system4.74362545
3MP0008057_abnormal_DNA_replication4.07577325
4MP0003705_abnormal_hypodermis_morpholog3.87335181
5MP0005365_abnormal_bile_salt3.83207408
6MP0005085_abnormal_gallbladder_physiolo3.42350924
7MP0002009_preneoplasia3.39214283
8MP0010234_abnormal_vibrissa_follicle3.27459531
9MP0003300_gastrointestinal_ulcer3.13843386
10MP0003252_abnormal_bile_duct3.03174442
11MP0008875_abnormal_xenobiotic_pharmacok2.74187416
12MP0000569_abnormal_digit_pigmentation2.73080350
13MP0003656_abnormal_erythrocyte_physiolo2.65111682
14MP0006054_spinal_hemorrhage2.58981838
15MP0005076_abnormal_cell_differentiation2.49628416
16MP0010352_gastrointestinal_tract_polyps2.26398120
17MP0003221_abnormal_cardiomyocyte_apopto2.20326864
18MP0004264_abnormal_extraembryonic_tissu2.11359299
19MP0002138_abnormal_hepatobiliary_system2.03391327
20MP0010329_abnormal_lipoprotein_level2.00109579
21MP0004808_abnormal_hematopoietic_stem1.98778692
22MP0003941_abnormal_skin_development1.98681286
23MP0005083_abnormal_biliary_tract1.98635983
24MP0004185_abnormal_adipocyte_glucose1.89826648
25MP0010307_abnormal_tumor_latency1.79546165
26MP0005451_abnormal_body_composition1.77870127
27MP0001666_abnormal_nutrient_absorption1.75959604
28MP0000465_gastrointestinal_hemorrhage1.74831128
29MP0001188_hyperpigmentation1.71316542
30MP0003890_abnormal_embryonic-extraembry1.64738788
31MP0000609_abnormal_liver_physiology1.62088702
32MP0003566_abnormal_cell_adhesion1.59981642
33MP0008961_abnormal_basal_metabolism1.57375152
34MP0003943_abnormal_hepatobiliary_system1.57371343
35MP0009840_abnormal_foam_cell1.49946483
36MP0003303_peritoneal_inflammation1.49073971
37MP0003868_abnormal_feces_composition1.48165882
38MP0003828_pulmonary_edema1.47589610
39MP0005409_darkened_coat_color1.46759113
40MP0004019_abnormal_vitamin_homeostasis1.46189175
41MP0001849_ear_inflammation1.40403634
42MP0004957_abnormal_blastocyst_morpholog1.40371580
43MP0003315_abnormal_perineum_morphology1.39594000
44MP0004272_abnormal_basement_membrane1.38412704
45MP0003091_abnormal_cell_migration1.37788765
46MP0005248_abnormal_Harderian_gland1.37592786
47MP0009053_abnormal_anal_canal1.37467937
48MP0010678_abnormal_skin_adnexa1.30647887
49MP0002796_impaired_skin_barrier1.28869729
50MP0005187_abnormal_penis_morphology1.26970247
51MP0003191_abnormal_cellular_cholesterol1.26493356
52MP0004883_abnormal_blood_vessel1.25580425
53MP0001915_intracranial_hemorrhage1.25223012
54MP0001879_abnormal_lymphatic_vessel1.24455264
55MP0000537_abnormal_urethra_morphology1.23187347
56MP0002254_reproductive_system_inflammat1.22769888
57MP0008004_abnormal_stomach_pH1.21904079
58MP0004084_abnormal_cardiac_muscle1.20952098
59MP0009697_abnormal_copulation1.19917179
60MP0003950_abnormal_plasma_membrane1.18113864
61MP0003453_abnormal_keratinocyte_physiol1.16981217
62MP0005666_abnormal_adipose_tissue1.14628265
63MP0002928_abnormal_bile_duct1.13295878
64MP0002086_abnormal_extraembryonic_tissu1.13265715
65MP0005275_abnormal_skin_tensile1.11939956
66MP0001881_abnormal_mammary_gland1.10343332
67MP0000733_abnormal_muscle_development1.09498174
68MP0002168_other_aberrant_phenotype1.00698143
69MP0005621_abnormal_cell_physiology1.00515522
70MP0002084_abnormal_developmental_patter0.99557117
71MP0003448_altered_tumor_morphology0.99494449
72MP0002396_abnormal_hematopoietic_system0.99281817
73MP0005023_abnormal_wound_healing0.98562034
74MP0008932_abnormal_embryonic_tissue0.97841790
75MP0003195_calcinosis0.97073719
76MP0005380_embryogenesis_phenotype0.97068232
77MP0001672_abnormal_embryogenesis/_devel0.97068232
78MP0009384_cardiac_valve_regurgitation0.96751282
79MP0003115_abnormal_respiratory_system0.96723141
80MP0001191_abnormal_skin_condition0.96144091
81MP0002088_abnormal_embryonic_growth/wei0.95871786
82MP0004947_skin_inflammation0.95758550
83MP0003787_abnormal_imprinting0.94588894
84MP0003984_embryonic_growth_retardation0.93763557
85MP0005395_other_phenotype0.93642771
86MP0002118_abnormal_lipid_homeostasis0.93550598
87MP0001730_embryonic_growth_arrest0.93277266
88MP0009672_abnormal_birth_weight0.92906131
89MP0003077_abnormal_cell_cycle0.92487360
90MP0005408_hypopigmentation0.92378923
91MP0005332_abnormal_amino_acid0.91601938
92MP0002233_abnormal_nose_morphology0.91199514
93MP0005464_abnormal_platelet_physiology0.91075991
94MP0000598_abnormal_liver_morphology0.90370100
95MP0000432_abnormal_head_morphology0.90335493
96MP0003755_abnormal_palate_morphology0.89770181
97MP0005501_abnormal_skin_physiology0.89082545
98MP0002098_abnormal_vibrissa_morphology0.88644886
99MP0004233_abnormal_muscle_weight0.88198789
100MP0004130_abnormal_muscle_cell0.88117890
101MP0000627_abnormal_mammary_gland0.87540671
102MP0005174_abnormal_tail_pigmentation0.86846254
103MP0003045_fibrosis0.86549835
104MP0002166_altered_tumor_susceptibility0.85642871
105MP0000427_abnormal_hair_cycle0.84947631
106MP0003937_abnormal_limbs/digits/tail_de0.84387584
107MP0009278_abnormal_bone_marrow0.84241314
108MP0001727_abnormal_embryo_implantation0.83761823
109MP0000462_abnormal_digestive_system0.83412628
110MP0005220_abnormal_exocrine_pancreas0.80654261
111MP0009703_decreased_birth_body0.79699074
112MP0005164_abnormal_response_to0.78647135
113MP0004036_abnormal_muscle_relaxation0.78464560
114MP0001299_abnormal_eye_distance/0.77939703
115MP0005384_cellular_phenotype0.77930105
116MP0001697_abnormal_embryo_size0.77325593
117MP0002006_tumorigenesis0.77044065
118MP0002877_abnormal_melanocyte_morpholog0.76803975
119MP0002092_abnormal_eye_morphology0.75648756
120MP0004197_abnormal_fetal_growth/weight/0.75563514
121MP0002896_abnormal_bone_mineralization0.75523210
122MP0002085_abnormal_embryonic_tissue0.73802745
123MP0000383_abnormal_hair_follicle0.73145798
124MP0004484_altered_response_of0.72801241
125MP0002060_abnormal_skin_morphology0.72739944
126MP0003718_maternal_effect0.72161921
127MP0000767_abnormal_smooth_muscle0.71796545
128MP0001216_abnormal_epidermal_layer0.71607049
129MP0000428_abnormal_craniofacial_morphol0.71538088
130MP0000647_abnormal_sebaceous_gland0.71491084
131MP0000516_abnormal_urinary_system0.71282711
132MP0005367_renal/urinary_system_phenotyp0.71282711
133MP0005375_adipose_tissue_phenotype0.69984828
134MP0000377_abnormal_hair_follicle0.69748120
135MP0002971_abnormal_brown_adipose0.69628550
136MP0002697_abnormal_eye_size0.69123681
137MP0000467_abnormal_esophagus_morphology0.69041156
138MP0003699_abnormal_female_reproductive0.68938029
139MP0000579_abnormal_nail_morphology0.68566884
140MP0000604_amyloidosis0.68212765
141MP0002925_abnormal_cardiovascular_devel0.67631317
142MP0005257_abnormal_intraocular_pressure0.67536691
143MP0009780_abnormal_chondrocyte_physiolo0.67222857
144MP0000350_abnormal_cell_proliferation0.66893824
145MP0003935_abnormal_craniofacial_develop0.65591974
146MP0005647_abnormal_sex_gland0.62227396
147MP0009643_abnormal_urine_homeostasis0.61260049
148MP0002102_abnormal_ear_morphology0.59538025
149MP0005319_abnormal_enzyme/_coenzyme0.59378120
150MP0003121_genomic_imprinting0.57976678

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.34975611
2Curly hair (HP:0002212)4.11416622
3Cortical dysplasia (HP:0002539)3.71352488
4Termporal pattern (HP:0011008)3.61871229
5Insidious onset (HP:0003587)3.61871229
6Intrahepatic cholestasis (HP:0001406)3.43146808
7Deep philtrum (HP:0002002)3.41393931
8Absent frontal sinuses (HP:0002688)3.23208099
9Papillary thyroid carcinoma (HP:0002895)3.12886846
10Esophageal varix (HP:0002040)3.03147657
11Myocardial infarction (HP:0001658)3.01174871
12Spinal cord lesions (HP:0100561)2.90580314
13Syringomyelia (HP:0003396)2.90580314
14Abnormality of the fingertips (HP:0001211)2.89013992
15Subacute progressive viral hepatitis (HP:0006572)2.88489081
16Abnormality of monocarboxylic acid metabolism (HP:0010996)2.88100144
17Hypobetalipoproteinemia (HP:0003563)2.86604226
18Abnormal platelet volume (HP:0011876)2.82776131
19Cystic hygroma (HP:0000476)2.80380163
20Sparse lateral eyebrow (HP:0005338)2.74991197
21Xanthomatosis (HP:0000991)2.74701661
22Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.69621768
23Heterotopia (HP:0002282)2.67353362
24Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65482979
25Epidermoid cyst (HP:0200040)2.62609915
26Hypoalphalipoproteinemia (HP:0003233)2.60556432
27Complement deficiency (HP:0004431)2.59989616
28Hypolipoproteinemia (HP:0010981)2.57558240
29Rectal prolapse (HP:0002035)2.55780382
30Bilateral sensorineural hearing impairment (HP:0008619)2.48554630
31Asymmetry of the thorax (HP:0001555)2.47193856
32Abnormality of sulfur amino acid metabolism (HP:0004339)2.46206257
33Abnormality of the common coagulation pathway (HP:0010990)2.41167856
34Hepatocellular carcinoma (HP:0001402)2.40296036
35Scanning speech (HP:0002168)2.37580942
36Abnormality of the vasculature of the conjunctiva (HP:0008054)2.37292743
37Relative macrocephaly (HP:0004482)2.34016416
38Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.33459162
39Tetraparesis (HP:0002273)2.30890747
40Male infertility (HP:0003251)2.30470932
41Muscle hypertrophy of the lower extremities (HP:0008968)2.29169666
42Acanthocytosis (HP:0001927)2.29026578
43Back pain (HP:0003418)2.23828540
44Long toe (HP:0010511)2.23061942
45Spastic diplegia (HP:0001264)2.21952455
46Overgrowth (HP:0001548)2.18393509
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16116238
48Pulmonic stenosis (HP:0001642)2.15647576
49Arterial tortuosity (HP:0005116)2.14701176
50Aortic aneurysm (HP:0004942)2.13797299
51Abnormality of the musculature of the pelvis (HP:0001469)2.13100060
52Abnormality of the hip-girdle musculature (HP:0001445)2.13100060
53Transitional cell carcinoma of the bladder (HP:0006740)2.12877616
54Spondylolisthesis (HP:0003302)2.12500702
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12436202
56Macroorchidism (HP:0000053)2.11169464
57Cubitus valgus (HP:0002967)2.10441709
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10127825
59Hypochromic microcytic anemia (HP:0004840)2.09843185
60Abnormality of the left ventricular outflow tract (HP:0011103)2.08832196
61Subaortic stenosis (HP:0001682)2.08832196
62Abnormal auditory evoked potentials (HP:0006958)2.06908191
63Gastrointestinal carcinoma (HP:0002672)2.06632583
64Malignant gastrointestinal tract tumors (HP:0006749)2.06632583
65Ankyloglossia (HP:0010296)2.05938513
66Neonatal hypoglycemia (HP:0001998)2.04848071
67Short middle phalanx of the 5th finger (HP:0004220)2.04264361
68Abnormality of purine metabolism (HP:0004352)2.02947993
69Mitral valve prolapse (HP:0001634)2.02929628
70Bladder neoplasm (HP:0009725)2.02667977
71Bladder carcinoma (HP:0002862)2.02667977
72Abnormality of nail color (HP:0100643)2.02637625
73Disinhibition (HP:0000734)2.02625790
74Shallow orbits (HP:0000586)2.02586752
75Conjunctival telangiectasia (HP:0000524)2.01775155
76Freckling (HP:0001480)2.01288412
77Abnormality of macular pigmentation (HP:0008002)2.01233244
78Metaphyseal dysplasia (HP:0100255)2.01210515
79Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.00540709
80Abnormality of the frontal sinuses (HP:0002687)2.00473405
81Central scotoma (HP:0000603)2.00386225
82Pelvic girdle muscle weakness (HP:0003749)2.00312832
83Dysmetric saccades (HP:0000641)1.99483210
84Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.97429522
85Pheochromocytoma (HP:0002666)1.95984433
86Hypercholesterolemia (HP:0003124)1.95481486
87Narrow palate (HP:0000189)1.95079012
88Volvulus (HP:0002580)1.94656881
89Spontaneous abortion (HP:0005268)1.94327220
90Cerebral aneurysm (HP:0004944)1.94254967
91Uterine leiomyosarcoma (HP:0002891)1.93955182
92Leiomyosarcoma (HP:0100243)1.93955182
93Enlarged penis (HP:0000040)1.93417925
94Aneurysm (HP:0002617)1.93120876
95Hematochezia (HP:0002573)1.92012517
96Large earlobe (HP:0009748)1.90581677
97Hip dysplasia (HP:0001385)1.90187832
98Exostoses (HP:0100777)1.89035527
99Biliary tract neoplasm (HP:0100574)1.88547110
100Lip pit (HP:0100267)1.86535632
101Shawl scrotum (HP:0000049)1.86183039
102Facial hemangioma (HP:0000329)1.86114987
103Thickened calvaria (HP:0002684)1.85355939
104Hyperglycemia (HP:0003074)1.85117680
105Vascular tortuosity (HP:0004948)1.83940055
106Oligodactyly (hands) (HP:0001180)1.82603403
107Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.82388896
108Gout (HP:0001997)1.81659644
109Abnormality of chromosome segregation (HP:0002916)1.79786992
110Hydroxyprolinuria (HP:0003080)1.79158520
111Abnormality of proline metabolism (HP:0010907)1.79158520
112Long clavicles (HP:0000890)1.79105519
113Rhabdomyosarcoma (HP:0002859)1.79043735
114Germ cell neoplasia (HP:0100728)1.78698146
115Increased number of teeth (HP:0011069)1.78519842
116Decreased skull ossification (HP:0004331)1.78219289
117Hypoplastic labia majora (HP:0000059)1.77301546
118Osteolytic defects of the hand bones (HP:0009699)1.77133520
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.77133520
120Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76968485
121Increased density of long bones (HP:0006392)1.76475354
122Urinary bladder sphincter dysfunction (HP:0002839)1.76207594
123Autoamputation (HP:0001218)1.75435068
124Sandal gap (HP:0001852)1.74935846
125Renal cell carcinoma (HP:0005584)1.74895847
126Striae distensae (HP:0001065)1.73141261
127Pseudobulbar signs (HP:0002200)1.72745606
128Right ventricular cardiomyopathy (HP:0011663)1.72689878
129Truncal obesity (HP:0001956)1.72452420
130Shoulder girdle muscle weakness (HP:0003547)1.72015236
131Acute myeloid leukemia (HP:0004808)1.71784405
132Upper motor neuron abnormality (HP:0002127)1.71718417
133Lymphangioma (HP:0100764)1.71704521
134Skin nodule (HP:0200036)1.71311290
135Acute lymphatic leukemia (HP:0006721)1.70927708
136Low posterior hairline (HP:0002162)1.69934649
137Embryonal renal neoplasm (HP:0011794)1.69855823
138Vertebral arch anomaly (HP:0008438)1.68847696
139Microglossia (HP:0000171)1.68029098
140Persistence of primary teeth (HP:0006335)1.67669674
141Peritonitis (HP:0002586)1.67054878
142Sensorimotor neuropathy (HP:0007141)1.66598692
143Inappropriate behavior (HP:0000719)1.66290269
144Nephroblastoma (Wilms tumor) (HP:0002667)1.65618854
145Abnormal foot bone ossification (HP:0010675)1.65415311
146Coarse hair (HP:0002208)1.64794990
147Abnormality of nucleobase metabolism (HP:0010932)1.64683100
148Prolonged partial thromboplastin time (HP:0003645)1.64620610
149Abnormality of complement system (HP:0005339)1.64582335
150Polycythemia (HP:0001901)1.63485063
151Abnormality of chromosome stability (HP:0003220)1.63379255
152Increased mean platelet volume (HP:0011877)1.63224984
153Thickened nuchal skin fold (HP:0000474)1.63214406
154Spontaneous hematomas (HP:0007420)1.63093550
155Focal segmental glomerulosclerosis (HP:0000097)1.62854915
156Neoplasm of the small intestine (HP:0100833)1.62801997
157Camptodactyly of toe (HP:0001836)1.62117187
158Thyroid carcinoma (HP:0002890)1.62007443
159Genetic anticipation (HP:0003743)1.61894103
160Abnormality of the labia majora (HP:0012881)1.61368553
161Oligodactyly (HP:0012165)1.60484379
162Cutis marmorata (HP:0000965)1.60163286
163Oligodontia (HP:0000677)1.60157639
164Cardiovascular calcification (HP:0011915)1.59015061
165Turricephaly (HP:0000262)1.58708952
166Midline defect of the nose (HP:0004122)1.58266320
167Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.57998161
168Short 4th metacarpal (HP:0010044)1.57998161
169Renovascular hypertension (HP:0100817)1.57409290
170Fat malabsorption (HP:0002630)1.56452650
171Vascular calcification (HP:0004934)1.55699616
172Hyperglycinemia (HP:0002154)1.55108248
173Abnormality of aspartate family amino acid metabolism (HP:0010899)1.55006360
174Abnormality of the nasal septum (HP:0000419)1.52949182
175Malnutrition (HP:0004395)1.52814925
176Ulnar bowing (HP:0003031)1.52018117
177Abnormality of the lower motor neuron (HP:0002366)1.51649779
178Hemorrhage of the eye (HP:0011885)1.50852139
179Joint hemorrhage (HP:0005261)1.50101369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.18382098
2TRPM73.95923693
3CDK123.38577361
4ERBB32.88128242
5LATS22.69659097
6TRIB32.67373506
7TAOK32.57553605
8EIF2AK32.54407685
9TRIM282.53538458
10PKN22.41038598
11SIK12.35563489
12STK32.27781689
13AKT32.19585871
14CASK2.10842406
15EEF2K2.08532533
16IRAK12.07675043
17BRSK22.06179596
18FRK1.97568381
19CAMK1D1.97180217
20PTK61.96882407
21BCR1.92384067
22BMPR21.90974259
23FGFR41.89663144
24ACVR1B1.79439892
25DMPK1.78634849
26YES11.77936160
27STK101.73663821
28STK38L1.72624435
29DYRK31.66031516
30RIPK11.64903054
31ERBB41.63002743
32FGFR31.58764345
33CAMK1G1.57288982
34MATK1.56175820
35MST41.55164620
36EIF2AK11.53928732
37WEE11.53152761
38SIK31.50243315
39MAP3K121.48725310
40ERN11.46357670
41STK241.45527355
42CDK61.43358791
43MKNK11.42580466
44NEK21.41716296
45TAOK11.40265611
46TNIK1.35454527
47RET1.28557606
48MAP3K101.25216274
49MAP3K91.25142514
50FGFR21.23160942
51CDC71.22420135
52EPHA21.21701321
53MKNK21.18717220
54PDGFRA1.15398503
55PDGFRB1.14455968
56MAP3K21.14199502
57LMTK21.14080179
58MTOR1.10169868
59KSR21.05637974
60MAP3K61.04675160
61MELK1.02867539
62PTK21.01582063
63NUAK11.01250097
64JAK11.00601163
65TYRO30.99559597
66EPHA30.97103904
67PNCK0.96902563
68ILK0.94833095
69SGK30.93989789
70MAP3K140.92050041
71EPHB10.89714644
72KSR10.89299720
73TTN0.89102546
74MET0.88119002
75CDK90.87891444
76MAP2K70.84513278
77PIK3CG0.84362747
78FER0.83796871
79RPS6KB10.82260680
80TTK0.82022165
81FLT30.81652451
82LRRK20.79962584
83PLK30.79154914
84STK390.79008107
85DDR20.78359754
86JAK20.76999254
87FGFR10.76751858
88PRKAA20.76293593
89NLK0.74696501
90NEK90.73857191
91ERBB20.73735254
92PRKAA10.72899350
93CHUK0.72340083
94CLK10.71352314
95SIK20.69021318
96CAMKK20.68356290
97JAK30.68107651
98SCYL20.64647976
99TSSK60.64453608
100RAF10.64283017
101STK380.64278786
102TYK20.63553259
103MAP3K80.61435578
104MST1R0.61334635
105IRAK20.60372602
106SGK20.59015973
107MAP2K40.58877347
108PAK40.57134138
109MAP3K70.56200740
110MAP3K40.55890720
111EPHB20.55881810
112PAK20.54506467
113CSNK1D0.51156217
114EGFR0.50250481
115EIF2AK20.49855599
116NEK60.48775510
117BMX0.48630104
118MARK20.48393716
119PBK0.47820414
120CDK40.47655775
121PLK20.47549047
122BRD40.47413606
123FGR0.46662992
124ALK0.46406078
125MAP3K50.45260467
126ATM0.44800421
127RPS6KB20.44694936
128CHEK20.43988953
129PAK60.42511523
130RPS6KA40.41435168
131ROCK10.40539950
132CSNK1G10.39630982
133MARK30.38645847
134GSK3A0.38340621
135MAPK110.38202149
136MOS0.37898347
137STK110.36736274
138TGFBR10.36161324
139ITK0.35404599
140CHEK10.35284862
141ABL10.34989651
142MAPK100.33921929
143IGF1R0.33347374
144TGFBR20.32926213
145DYRK1B0.32704849
146CSK0.32548954
147PLK40.32266440
148BRAF0.32122338
149IRAK30.31924043
150CSNK1A1L0.31804198
151PIK3CA0.29415024
152PAK30.28755494

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.55888488
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.47848084
3Arginine biosynthesis_Homo sapiens_hsa002202.43470923
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.42015802
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40366393
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96958929
7Caffeine metabolism_Homo sapiens_hsa002321.87691915
8Complement and coagulation cascades_Homo sapiens_hsa046101.83341924
9Lysine degradation_Homo sapiens_hsa003101.80399463
10Non-homologous end-joining_Homo sapiens_hsa034501.64356475
11Thyroid cancer_Homo sapiens_hsa052161.63589572
12Adherens junction_Homo sapiens_hsa045201.53648664
13Staphylococcus aureus infection_Homo sapiens_hsa051501.50552037
14Legionellosis_Homo sapiens_hsa051341.47290839
15Tryptophan metabolism_Homo sapiens_hsa003801.44705377
16Acute myeloid leukemia_Homo sapiens_hsa052211.40992311
17Pancreatic cancer_Homo sapiens_hsa052121.35692605
18Bile secretion_Homo sapiens_hsa049761.34615188
19mTOR signaling pathway_Homo sapiens_hsa041501.32108924
20PPAR signaling pathway_Homo sapiens_hsa033201.30498955
21Platelet activation_Homo sapiens_hsa046111.29437795
22Steroid biosynthesis_Homo sapiens_hsa001001.24435446
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23639150
24Insulin resistance_Homo sapiens_hsa049311.19421141
25Sphingolipid metabolism_Homo sapiens_hsa006001.19130737
26Fatty acid degradation_Homo sapiens_hsa000711.18746413
27Small cell lung cancer_Homo sapiens_hsa052221.16884842
28Inositol phosphate metabolism_Homo sapiens_hsa005621.13945577
29Dorso-ventral axis formation_Homo sapiens_hsa043201.13315764
30MicroRNAs in cancer_Homo sapiens_hsa052061.13205315
31Butanoate metabolism_Homo sapiens_hsa006501.10620085
32B cell receptor signaling pathway_Homo sapiens_hsa046621.10153149
33Chronic myeloid leukemia_Homo sapiens_hsa052201.08453734
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08405576
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08268423
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05867306
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03899130
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.02859706
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01982202
40Melanoma_Homo sapiens_hsa052180.99719254
41Endometrial cancer_Homo sapiens_hsa052130.99262840
42Selenocompound metabolism_Homo sapiens_hsa004500.99074282
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98451513
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95632303
45Cell cycle_Homo sapiens_hsa041100.94541543
46Type II diabetes mellitus_Homo sapiens_hsa049300.94043773
47Proteoglycans in cancer_Homo sapiens_hsa052050.93674934
48Renal cell carcinoma_Homo sapiens_hsa052110.93157358
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93050892
50Prolactin signaling pathway_Homo sapiens_hsa049170.91531994
51Fat digestion and absorption_Homo sapiens_hsa049750.91195199
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90615412
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88429411
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87694185
55Shigellosis_Homo sapiens_hsa051310.86566020
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.86047800
57TGF-beta signaling pathway_Homo sapiens_hsa043500.85904945
58Axon guidance_Homo sapiens_hsa043600.84603273
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84471345
60Colorectal cancer_Homo sapiens_hsa052100.84212534
61FoxO signaling pathway_Homo sapiens_hsa040680.84042789
62Measles_Homo sapiens_hsa051620.83547754
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82616852
64Malaria_Homo sapiens_hsa051440.82600116
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82260637
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.82195598
67Retinol metabolism_Homo sapiens_hsa008300.81961479
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81888963
69Salmonella infection_Homo sapiens_hsa051320.81208135
70Amoebiasis_Homo sapiens_hsa051460.78860239
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78785756
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.78517021
73Toxoplasmosis_Homo sapiens_hsa051450.77933066
74AMPK signaling pathway_Homo sapiens_hsa041520.77405211
75Starch and sucrose metabolism_Homo sapiens_hsa005000.77034149
76Fatty acid metabolism_Homo sapiens_hsa012120.76055892
77Hippo signaling pathway_Homo sapiens_hsa043900.76053345
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75722528
79Focal adhesion_Homo sapiens_hsa045100.75371365
80ABC transporters_Homo sapiens_hsa020100.74920064
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73275244
82Chemokine signaling pathway_Homo sapiens_hsa040620.73035488
83Pathways in cancer_Homo sapiens_hsa052000.72987379
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72562019
85African trypanosomiasis_Homo sapiens_hsa051430.71965684
86Gap junction_Homo sapiens_hsa045400.71629499
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70793317
88Non-small cell lung cancer_Homo sapiens_hsa052230.70569793
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70128074
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.69868412
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.68930738
92mRNA surveillance pathway_Homo sapiens_hsa030150.68633614
93Prostate cancer_Homo sapiens_hsa052150.68300670
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67347848
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67186033
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66730669
97Chemical carcinogenesis_Homo sapiens_hsa052040.66710322
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65955681
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65908736
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65313278
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65046699
102TNF signaling pathway_Homo sapiens_hsa046680.64575121
103Basal transcription factors_Homo sapiens_hsa030220.63673926
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62795981
105Endocytosis_Homo sapiens_hsa041440.62625544
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62410228
107Glioma_Homo sapiens_hsa052140.60320423
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59972868
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59876337
110Histidine metabolism_Homo sapiens_hsa003400.59591229
111Insulin signaling pathway_Homo sapiens_hsa049100.59531886
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.59133806
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58834766
114Fatty acid biosynthesis_Homo sapiens_hsa000610.58797827
115Osteoclast differentiation_Homo sapiens_hsa043800.56844271
116Rap1 signaling pathway_Homo sapiens_hsa040150.56714921
117Wnt signaling pathway_Homo sapiens_hsa043100.55902226
118VEGF signaling pathway_Homo sapiens_hsa043700.55354795
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.55168001
120beta-Alanine metabolism_Homo sapiens_hsa004100.55096146
121Peroxisome_Homo sapiens_hsa041460.54883751
122Hepatitis B_Homo sapiens_hsa051610.54881370
123Ovarian steroidogenesis_Homo sapiens_hsa049130.53891065
124Bladder cancer_Homo sapiens_hsa052190.53871220
125Hepatitis C_Homo sapiens_hsa051600.53459850
126Tuberculosis_Homo sapiens_hsa051520.51792115
127Glucagon signaling pathway_Homo sapiens_hsa049220.51280356
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50817182
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.50795993
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50274935
131Viral myocarditis_Homo sapiens_hsa054160.49941355
132Glycerolipid metabolism_Homo sapiens_hsa005610.49798505
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49447717
134Viral carcinogenesis_Homo sapiens_hsa052030.48257162
135Choline metabolism in cancer_Homo sapiens_hsa052310.47872242
136Propanoate metabolism_Homo sapiens_hsa006400.47232353
137ErbB signaling pathway_Homo sapiens_hsa040120.46506736
138Phenylalanine metabolism_Homo sapiens_hsa003600.44728471
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43109425
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.43083542
141ECM-receptor interaction_Homo sapiens_hsa045120.42308182
142Tight junction_Homo sapiens_hsa045300.41705268
143p53 signaling pathway_Homo sapiens_hsa041150.40901891
144Estrogen signaling pathway_Homo sapiens_hsa049150.40725335
145Biosynthesis of amino acids_Homo sapiens_hsa012300.40215117
146T cell receptor signaling pathway_Homo sapiens_hsa046600.38839338
147Influenza A_Homo sapiens_hsa051640.38470279
148Circadian rhythm_Homo sapiens_hsa047100.38305131

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