SCYL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.13290085
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)7.01101663
3membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.63258374
4membrane repolarization during action potential (GO:0086011)6.01782572
5response to lipoprotein particle (GO:0055094)5.96433671
6intestinal epithelial cell development (GO:0060576)5.26165712
7DNA deamination (GO:0045006)5.07724649
8water-soluble vitamin biosynthetic process (GO:0042364)5.03011279
9proteasome assembly (GO:0043248)4.86483316
10organ formation (GO:0048645)4.71758428
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.71407200
12termination of RNA polymerase III transcription (GO:0006386)4.71407200
13ribosomal small subunit biogenesis (GO:0042274)4.71135440
14regulation of nuclear cell cycle DNA replication (GO:0033262)4.69835999
15rRNA modification (GO:0000154)4.68740159
16regulation of skeletal muscle contraction (GO:0014819)4.58222340
17ribosome assembly (GO:0042255)4.53252921
18regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.49406134
19behavioral response to nicotine (GO:0035095)4.46160048
20maturation of SSU-rRNA (GO:0030490)4.32948984
217-methylguanosine mRNA capping (GO:0006370)4.23518285
22cAMP catabolic process (GO:0006198)4.22142627
23protein-cofactor linkage (GO:0018065)4.18911576
24RNA capping (GO:0036260)4.17976858
257-methylguanosine RNA capping (GO:0009452)4.17976858
26telomere maintenance via semi-conservative replication (GO:0032201)4.17142993
27regulation of female receptivity (GO:0045924)4.16524695
28DNA replication checkpoint (GO:0000076)4.10928579
29DNA damage response, detection of DNA damage (GO:0042769)4.09338709
30deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.07910034
31middle ear morphogenesis (GO:0042474)4.04247235
32deoxyribonucleotide biosynthetic process (GO:0009263)4.03526143
33mitochondrial DNA replication (GO:0006264)4.01711398
34respiratory tube development (GO:0030323)4.00660940
35embryonic skeletal joint morphogenesis (GO:0060272)4.00370414
36histone H4-K12 acetylation (GO:0043983)3.99150703
37ribosomal large subunit biogenesis (GO:0042273)3.98396665
38RNA destabilization (GO:0050779)3.97465286
39regulation of mitochondrial translation (GO:0070129)3.94732836
40NADH dehydrogenase complex assembly (GO:0010257)3.92383514
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92383514
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.92383514
43deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.90517586
44membrane repolarization (GO:0086009)3.87070607
45DNA strand elongation involved in DNA replication (GO:0006271)3.85216442
46negative regulation of mast cell activation (GO:0033004)3.83599330
47ribonucleoprotein complex biogenesis (GO:0022613)3.83432650
48positive regulation of triglyceride biosynthetic process (GO:0010867)3.81047331
49regulation of double-strand break repair via homologous recombination (GO:0010569)3.80301029
50RNA methylation (GO:0001510)3.79942930
51rRNA methylation (GO:0031167)3.77341394
52DNA-dependent DNA replication (GO:0006261)3.77325410
53transcription-coupled nucleotide-excision repair (GO:0006283)3.75055584
54negative regulation of DNA-dependent DNA replication (GO:2000104)3.70534067
55positive regulation of potassium ion transmembrane transport (GO:1901381)3.68468722
56DNA strand elongation (GO:0022616)3.67442241
57magnesium ion transport (GO:0015693)3.66950083
58cyclic nucleotide catabolic process (GO:0009214)3.66232647
59somite development (GO:0061053)3.65613887
60transepithelial transport (GO:0070633)3.64808986
61telomere maintenance via recombination (GO:0000722)3.63850801
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62982972
63transcription elongation from RNA polymerase I promoter (GO:0006362)3.61798764
64transcription from RNA polymerase I promoter (GO:0006360)3.61144130
65termination of RNA polymerase I transcription (GO:0006363)3.60456300
66positive regulation of megakaryocyte differentiation (GO:0045654)3.55286814
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52140850
68regulation of glomerulus development (GO:0090192)3.49528824
69DNA replication initiation (GO:0006270)3.48419138
70ribosome biogenesis (GO:0042254)3.46979019
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45781771
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45781771
73cellular potassium ion homeostasis (GO:0030007)3.43435542
74lymphangiogenesis (GO:0001946)3.42740737
75morphogenesis of an endothelium (GO:0003159)3.42120513
76endothelial tube morphogenesis (GO:0061154)3.42120513
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40892143
78maturation of 5.8S rRNA (GO:0000460)3.40575134
79female mating behavior (GO:0060180)3.37897656
80rRNA processing (GO:0006364)3.37791593
81artery development (GO:0060840)3.37430420
82regulation of mesoderm development (GO:2000380)3.36873141
83regulation of triglyceride catabolic process (GO:0010896)3.36203803
84establishment of protein localization to mitochondrial membrane (GO:0090151)3.35151136
85regulation of membrane repolarization (GO:0060306)3.34789200
86telomere maintenance via telomere lengthening (GO:0010833)3.33891693
87lung morphogenesis (GO:0060425)3.32836159
88positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.31256658
89GTP biosynthetic process (GO:0006183)3.31237250
90rRNA metabolic process (GO:0016072)3.29446159
91pituitary gland development (GO:0021983)3.29266353
92regulation of cellular amino acid metabolic process (GO:0006521)3.27915388
93tRNA methylation (GO:0030488)3.27478836
94negative regulation of T cell differentiation in thymus (GO:0033085)3.26814144
95purine nucleobase biosynthetic process (GO:0009113)3.26043236
96protein complex biogenesis (GO:0070271)3.24481308
97mitotic recombination (GO:0006312)3.23248204
98spliceosomal snRNP assembly (GO:0000387)3.22391412
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.21375076
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.21375076
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.21375076
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20658770
103amino acid salvage (GO:0043102)3.18364318
104L-methionine salvage (GO:0071267)3.18364318
105L-methionine biosynthetic process (GO:0071265)3.18364318
106DNA synthesis involved in DNA repair (GO:0000731)3.16827797
107anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15940022
108positive regulation of endothelial cell differentiation (GO:0045603)3.15565595
109nucleobase biosynthetic process (GO:0046112)3.15425650
110cellular component biogenesis (GO:0044085)3.14143620
111negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13914876
112negative regulation of ligase activity (GO:0051352)3.13914876
113signal transduction involved in DNA damage checkpoint (GO:0072422)3.13185218
114signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13185218
115pseudouridine synthesis (GO:0001522)3.13145970
116positive regulation of fatty acid oxidation (GO:0046321)3.12228640
117ribosomal small subunit assembly (GO:0000028)3.11349495
118negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.10562195
119signal transduction involved in cell cycle checkpoint (GO:0072395)3.10479521
120nucleotide-excision repair, DNA gap filling (GO:0006297)3.08958806
121regulation of cardioblast proliferation (GO:0003264)3.07752362
122regulation of secondary heart field cardioblast proliferation (GO:0003266)3.07752362
123platelet dense granule organization (GO:0060155)3.07117693
124mRNA modification (GO:0016556)3.05854936
125spliceosomal complex assembly (GO:0000245)3.05618769
126positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.05474120
127UTP biosynthetic process (GO:0006228)3.04478801
128cell proliferation in forebrain (GO:0021846)3.02651999
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02165122
130pancreas development (GO:0031016)3.01987970
131nucleobase-containing small molecule interconversion (GO:0015949)3.01902605
132centriole replication (GO:0007099)3.01133840
133transcription initiation from RNA polymerase I promoter (GO:0006361)2.99992542
134DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.99620188
135organ induction (GO:0001759)2.99002948
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98020566
137vitamin biosynthetic process (GO:0009110)2.97622322
138piRNA metabolic process (GO:0034587)2.97387945
139CENP-A containing nucleosome assembly (GO:0034080)2.97065622
140negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.96685894
141translation (GO:0006412)2.96059490
142transcription elongation from RNA polymerase II promoter (GO:0006368)2.95679974
143viral transcription (GO:0019083)2.95077361
144intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94087549
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94087549
146positive regulation of viral transcription (GO:0050434)2.93620588
147mitochondrial respiratory chain complex assembly (GO:0033108)2.92292282
148regulation of heart rate by cardiac conduction (GO:0086091)2.92284722
149chromatin remodeling at centromere (GO:0031055)2.91470247
150mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90826149
151membrane depolarization during action potential (GO:0086010)2.90474124
152endoderm formation (GO:0001706)2.90119735
153translational termination (GO:0006415)2.89988685
154cellular response to ATP (GO:0071318)2.89774426
155positive regulation of defense response to virus by host (GO:0002230)2.88638516
156DNA methylation involved in gamete generation (GO:0043046)2.88452506
157guanosine-containing compound biosynthetic process (GO:1901070)2.88139328
158negative regulation of DNA biosynthetic process (GO:2000279)2.86691897
159mitotic metaphase plate congression (GO:0007080)2.86362826
160antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.86265042
161cytidine metabolic process (GO:0046087)2.82978367
162cytidine catabolic process (GO:0006216)2.82978367
163cytidine deamination (GO:0009972)2.82978367
164positive regulation of glomerulus development (GO:0090193)2.82952951
165positive regulation of oligodendrocyte differentiation (GO:0048714)2.81484070
166regulation of triglyceride biosynthetic process (GO:0010866)2.81447343
167regulation of organ formation (GO:0003156)2.79981568
168negative regulation of telomere maintenance (GO:0032205)2.76829744
169spinal cord development (GO:0021510)2.75179432
170indolalkylamine metabolic process (GO:0006586)2.73146983
171potassium ion import (GO:0010107)2.72951978
172sulfation (GO:0051923)2.71777924
173response to xenobiotic stimulus (GO:0009410)2.71251353
174regulation of regulatory T cell differentiation (GO:0045589)2.70327244
175pharyngeal system development (GO:0060037)2.69908764
176intra-S DNA damage checkpoint (GO:0031573)2.68588228
177negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.68124439
178positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.62864429
179regulation of lipoprotein particle clearance (GO:0010984)2.62574396
180regulation of cytokine production involved in inflammatory response (GO:1900015)2.62099807
181regulation of endothelial cell differentiation (GO:0045601)2.61445107
182head development (GO:0060322)2.61231727
183negative regulation of telomerase activity (GO:0051974)2.61044351
184regulation of sequestering of triglyceride (GO:0010889)2.60819347
185axoneme assembly (GO:0035082)2.60752315
186relaxation of cardiac muscle (GO:0055119)2.60449190
187prostate gland growth (GO:0060736)2.59796608
188cellular response to exogenous dsRNA (GO:0071360)2.59672920
189protein polyglutamylation (GO:0018095)2.58471690
190mesonephros development (GO:0001823)2.58120354
191indole-containing compound catabolic process (GO:0042436)2.57681053
192indolalkylamine catabolic process (GO:0046218)2.57681053
193tryptophan catabolic process (GO:0006569)2.57681053
194synaptic transmission, cholinergic (GO:0007271)2.57259940
195negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57099823
196DNA damage response, signal transduction resulting in transcription (GO:0042772)2.56204535
197double-strand break repair via homologous recombination (GO:0000724)2.55956038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.66720054
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.92190402
3EZH2_22144423_ChIP-Seq_EOC_Human4.31758379
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.18856214
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.89194758
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.85577870
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.83645861
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.64020621
9VDR_22108803_ChIP-Seq_LS180_Human3.59976999
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.28151544
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11588331
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.93068222
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90782047
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88332890
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84060485
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83930457
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80368244
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78859996
19* VDR_23849224_ChIP-Seq_CD4+_Human2.78337020
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.76782406
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74145263
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70583632
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67015994
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60928315
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60689812
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53715719
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53294822
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51239530
29ZNF274_21170338_ChIP-Seq_K562_Hela2.49491791
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39656482
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31610227
32FOXP3_21729870_ChIP-Seq_TREG_Human2.28915796
33GBX2_23144817_ChIP-Seq_PC3_Human2.27008741
34XRN2_22483619_ChIP-Seq_HELA_Human2.24517533
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15133564
36ELK1_19687146_ChIP-ChIP_HELA_Human2.12652442
37JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12649478
38EZH2_27304074_Chip-Seq_ESCs_Mouse2.08164085
39SRF_21415370_ChIP-Seq_HL-1_Mouse2.06585972
40DCP1A_22483619_ChIP-Seq_HELA_Human2.02455192
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01326305
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.99333188
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.97977877
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95298498
45* YY1_21170310_ChIP-Seq_MESCs_Mouse1.93118080
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87838006
47* TTF2_22483619_ChIP-Seq_HELA_Human1.87683660
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87519065
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86552103
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85644219
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.84845293
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84139548
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83436551
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82421770
55GABP_19822575_ChIP-Seq_HepG2_Human1.81952350
56* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76054065
57* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74962706
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74286835
59RNF2_27304074_Chip-Seq_NSC_Mouse1.73167520
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72787583
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.71597721
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70850385
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66887438
64* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65656346
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64279829
66* CIITA_25753668_ChIP-Seq_RAJI_Human1.62086849
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61785853
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.59764732
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.57429383
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.55504411
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53558781
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51291647
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49876153
74* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48848409
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46875285
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45132696
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43065140
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42040073
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.41851361
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.41584151
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37215427
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37117636
83EWS_26573619_Chip-Seq_HEK293_Human1.35421409
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.35240175
85* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34277787
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32797034
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32421540
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31878379
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31186550
90P300_19829295_ChIP-Seq_ESCs_Human1.30432129
91MYC_18940864_ChIP-ChIP_HL60_Human1.27901809
92RNF2_27304074_Chip-Seq_ESCs_Mouse1.27790449
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27245762
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.26876890
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.26397830
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25778001
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25705825
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25056558
99AR_25329375_ChIP-Seq_VCAP_Human1.24546088
100* ELK1_22589737_ChIP-Seq_MCF10A_Human1.24428684
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24400439
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.24342599
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.24044563
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22843068
105CBP_20019798_ChIP-Seq_JUKART_Human1.22843068
106RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22251357
107EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22251357
108KDM5A_27292631_Chip-Seq_BREAST_Human1.22085311
109FUS_26573619_Chip-Seq_HEK293_Human1.21477393
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21476685
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21420701
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.19521201
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19521201
114ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17365968
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17056634
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17008849
117IGF1R_20145208_ChIP-Seq_DFB_Human1.16384483
118NANOG_19829295_ChIP-Seq_ESCs_Human1.16287883
119SOX2_19829295_ChIP-Seq_ESCs_Human1.16287883
120STAT3_23295773_ChIP-Seq_U87_Human1.14009314
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13798725
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13366019
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12985277
124EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12694817
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12483949
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11957132
127* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11886409
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.11560973
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11067142
130TCF4_23295773_ChIP-Seq_U87_Human1.10938216
131REST_21632747_ChIP-Seq_MESCs_Mouse1.10718430
132* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10659110
133TP53_22573176_ChIP-Seq_HFKS_Human1.09666465
134LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09052048
135ARNT_22903824_ChIP-Seq_MCF-7_Human1.08904929
136ER_23166858_ChIP-Seq_MCF-7_Human1.07454182
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.07358394
138MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06810024
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06732752
140SMAD4_21799915_ChIP-Seq_A2780_Human1.06278245
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05675753
142TAF2_19829295_ChIP-Seq_ESCs_Human1.05460846
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04000204
144AHR_22903824_ChIP-Seq_MCF-7_Human1.03352574
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03343930
146CTCF_20526341_ChIP-Seq_ESCs_Human1.02765681
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02387522
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02036023
149FOXH1_21741376_ChIP-Seq_EPCs_Human1.01090317
150SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01076347
151NANOG_20526341_ChIP-Seq_ESCs_Human1.00713315
152POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00532279
153NCOR_22424771_ChIP-Seq_293T_Human1.00124461
154MYC_19829295_ChIP-Seq_ESCs_Human0.98011265
155SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97945745
156KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97304030
157AR_21909140_ChIP-Seq_LNCAP_Human0.96596488
158CDX2_22108803_ChIP-Seq_LS180_Human0.94484637
159KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94261747
160SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92884316
161SMRT_27268052_Chip-Seq_Bcells_Human0.92665184
162FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92213914
163KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92123716
164SOX17_20123909_ChIP-Seq_XEN_Mouse0.91411651
165* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91312192
166FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91254559
167GATA1_22025678_ChIP-Seq_K562_Human0.90228378
168CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88253857
169SPI1_23547873_ChIP-Seq_NB4_Human0.86132334
170* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85728973
171* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84934420
172IRF1_19129219_ChIP-ChIP_H3396_Human0.82772172
173GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82319222
174DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81338569
175HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79332372
176NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78077180
177RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77809899
178HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76953300
179FLI1_27457419_Chip-Seq_LIVER_Mouse0.76873400
180KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76121016
181KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76121016
182KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76121016
183MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.73231770
184DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73002681
185IRF8_21731497_ChIP-ChIP_J774_Mouse0.70899159
186CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70882183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ8.26621392
2MP0008057_abnormal_DNA_replication4.62178117
3MP0003693_abnormal_embryo_hatching4.61766207
4MP0003111_abnormal_nucleus_morphology3.89095116
5MP0002138_abnormal_hepatobiliary_system3.84177004
6MP0008058_abnormal_DNA_repair3.76020109
7MP0005646_abnormal_pituitary_gland3.62146449
8MP0008877_abnormal_DNA_methylation3.52187907
9MP0010094_abnormal_chromosome_stability3.17868030
10MP0000049_abnormal_middle_ear2.98567916
11MP0003724_increased_susceptibility_to2.93332843
12MP0002102_abnormal_ear_morphology2.77798170
13MP0003077_abnormal_cell_cycle2.70488277
14MP0003718_maternal_effect2.55417706
15MP0004885_abnormal_endolymph2.54166054
16MP0004957_abnormal_blastocyst_morpholog2.48696673
17MP0001485_abnormal_pinna_reflex2.38845161
18MP0004381_abnormal_hair_follicle2.33949473
19MP0003786_premature_aging2.29213154
20MP0003938_abnormal_ear_development2.29205691
21MP0003119_abnormal_digestive_system2.27666522
22MP0002160_abnormal_reproductive_system2.26501084
23MP0000566_synostosis2.25403788
24MP0008007_abnormal_cellular_replicative2.19462621
25MP0003806_abnormal_nucleotide_metabolis2.17758766
26MP0000631_abnormal_neuroendocrine_gland2.13867900
27MP0008932_abnormal_embryonic_tissue2.13800243
28MP0004134_abnormal_chest_morphology2.13375647
29MP0009379_abnormal_foot_pigmentation2.06230909
30MP0001853_heart_inflammation2.03356681
31MP0000013_abnormal_adipose_tissue1.99595138
32MP0001188_hyperpigmentation1.94637853
33MP0005389_reproductive_system_phenotype1.90646653
34MP0003879_abnormal_hair_cell1.85701017
35MP0002751_abnormal_autonomic_nervous1.80278869
36MP0003646_muscle_fatigue1.75847832
37MP0006292_abnormal_olfactory_placode1.73283666
38MP0002210_abnormal_sex_determination1.71725508
39MP0005409_darkened_coat_color1.66433461
40MP0004130_abnormal_muscle_cell1.65631326
41MP0003941_abnormal_skin_development1.64477167
42MP0000516_abnormal_urinary_system1.61579846
43MP0005367_renal/urinary_system_phenotyp1.61579846
44MP0006035_abnormal_mitochondrial_morpho1.59607899
45MP0008995_early_reproductive_senescence1.53984115
46MP0001929_abnormal_gametogenesis1.53569922
47MP0001529_abnormal_vocalization1.52710959
48MP0002277_abnormal_respiratory_mucosa1.51901489
49MP0001145_abnormal_male_reproductive1.48753390
50MP0009780_abnormal_chondrocyte_physiolo1.47626518
51MP0001968_abnormal_touch/_nociception1.44911316
52MP0001764_abnormal_homeostasis1.44456694
53MP0005075_abnormal_melanosome_morpholog1.44446272
54MP0005670_abnormal_white_adipose1.41017792
55MP0005551_abnormal_eye_electrophysiolog1.37171606
56MP0001986_abnormal_taste_sensitivity1.36691550
57MP0003763_abnormal_thymus_physiology1.34917918
58MP0000653_abnormal_sex_gland1.34353032
59MP0002837_dystrophic_cardiac_calcinosis1.34219638
60MP0003195_calcinosis1.33873842
61MP0003890_abnormal_embryonic-extraembry1.32095343
62MP0005174_abnormal_tail_pigmentation1.27081717
63MP0001919_abnormal_reproductive_system1.25678436
64MP0002272_abnormal_nervous_system1.25341159
65MP0005423_abnormal_somatic_nervous1.24945084
66MP0000703_abnormal_thymus_morphology1.20829123
67MP0008260_abnormal_autophagy1.20087308
68MP0009053_abnormal_anal_canal1.18513567
69MP0000313_abnormal_cell_death1.17772766
70MP0005645_abnormal_hypothalamus_physiol1.16716631
71MP0003186_abnormal_redox_activity1.16649779
72MP0003011_delayed_dark_adaptation1.16237141
73MP0003567_abnormal_fetal_cardiomyocyte1.15636250
74MP0003937_abnormal_limbs/digits/tail_de1.15576970
75MP0000015_abnormal_ear_pigmentation1.14626212
76MP0003698_abnormal_male_reproductive1.12595305
77MP0003123_paternal_imprinting1.08349168
78MP0002876_abnormal_thyroid_physiology1.08328324
79MP0009250_abnormal_appendicular_skeleto1.07105362
80MP0003315_abnormal_perineum_morphology1.06816857
81MP0002132_abnormal_respiratory_system1.06777100
82MP0001440_abnormal_grooming_behavior1.05884914
83MP0000689_abnormal_spleen_morphology1.05036881
84MP0009333_abnormal_splenocyte_physiolog1.04828924
85MP0000613_abnormal_salivary_gland1.03364142
86MP0002722_abnormal_immune_system1.03219987
87MP0000470_abnormal_stomach_morphology1.00579349
88MP0006072_abnormal_retinal_apoptosis0.99385541
89MP0001800_abnormal_humoral_immune0.98758569
90MP0005000_abnormal_immune_tolerance0.97818975
91MP0008872_abnormal_physiological_respon0.96925617
92MP0008789_abnormal_olfactory_epithelium0.96750938
93MP0002249_abnormal_larynx_morphology0.96589548
94MP0000678_abnormal_parathyroid_gland0.96008457
95MP0009697_abnormal_copulation0.95336142
96MP0009745_abnormal_behavioral_response0.94865129
97MP0002723_abnormal_immune_serum0.94305647
98MP0002019_abnormal_tumor_incidence0.93092417
99MP0004145_abnormal_muscle_electrophysio0.91966134
100MP0002398_abnormal_bone_marrow0.91865147
101MP0000350_abnormal_cell_proliferation0.91387841
102MP0005395_other_phenotype0.90774204
103MP0005408_hypopigmentation0.90723410
104MP0001119_abnormal_female_reproductive0.90114973
105MP0005379_endocrine/exocrine_gland_phen0.89479961
106MP0003950_abnormal_plasma_membrane0.88967615
107MP0001730_embryonic_growth_arrest0.87900701
108MP0001905_abnormal_dopamine_level0.86998307
109MP0002736_abnormal_nociception_after0.86885161
110MP0002733_abnormal_thermal_nociception0.85977383
111MP0004019_abnormal_vitamin_homeostasis0.84714027
112MP0001661_extended_life_span0.84711525
113MP0006276_abnormal_autonomic_nervous0.84593013
114MP0000685_abnormal_immune_system0.84128215
115MP0003121_genomic_imprinting0.83659456
116MP0002420_abnormal_adaptive_immunity0.83031979
117MP0000716_abnormal_immune_system0.82877562
118MP0001963_abnormal_hearing_physiology0.82691468
119MP0000026_abnormal_inner_ear0.82659107
120MP0001835_abnormal_antigen_presentation0.82498032
121MP0001819_abnormal_immune_cell0.81859982
122MP0005332_abnormal_amino_acid0.81553847
123MP0000681_abnormal_thyroid_gland0.81052113
124MP0009765_abnormal_xenobiotic_induced0.80522869
125MP0005384_cellular_phenotype0.80118217
126MP0000358_abnormal_cell_content/0.79617509
127MP0006036_abnormal_mitochondrial_physio0.78196325
128MP0002452_abnormal_antigen_presenting0.77941421
129MP0004133_heterotaxia0.77930488
130MP0001765_abnormal_ion_homeostasis0.77546989
131MP0005671_abnormal_response_to0.77072552
132MP0004142_abnormal_muscle_tone0.76822501
133MP0005410_abnormal_fertilization0.75811446
134MP0002282_abnormal_trachea_morphology0.75803061
135MP0000462_abnormal_digestive_system0.75569365
136MP0002429_abnormal_blood_cell0.74961947
137MP0003936_abnormal_reproductive_system0.74393912
138MP0009046_muscle_twitch0.74026614
139MP0008875_abnormal_xenobiotic_pharmacok0.73514404
140MP0000465_gastrointestinal_hemorrhage0.72950659
141MP0001186_pigmentation_phenotype0.72684490
142MP0005253_abnormal_eye_physiology0.72172549
143MP0000490_abnormal_crypts_of0.72093986
144MP0008469_abnormal_protein_level0.71385844
145MP0002734_abnormal_mechanical_nocicepti0.70265174
146MP0000230_abnormal_systemic_arterial0.70177298
147MP0002735_abnormal_chemical_nociception0.70155345
148MP0003436_decreased_susceptibility_to0.70119467
149MP0000647_abnormal_sebaceous_gland0.69890162
150MP0002396_abnormal_hematopoietic_system0.69854783
151MP0002139_abnormal_hepatobiliary_system0.69391626
152MP0000427_abnormal_hair_cycle0.69295669
153MP0002177_abnormal_outer_ear0.69011997
154MP0001970_abnormal_pain_threshold0.67413770
155MP0002419_abnormal_innate_immunity0.66817160
156MP0005621_abnormal_cell_physiology0.66764939
157MP0000383_abnormal_hair_follicle0.66688342
158MP0002098_abnormal_vibrissa_morphology0.66586728
159MP0002095_abnormal_skin_pigmentation0.66570932
160MP0003942_abnormal_urinary_system0.66507647
161MP0005464_abnormal_platelet_physiology0.66125142
162MP0002909_abnormal_adrenal_gland0.66073173
163MP0005195_abnormal_posterior_eye0.64016842
164MP0004185_abnormal_adipocyte_glucose0.63581064
165MP0001879_abnormal_lymphatic_vessel0.62136576
166MP0004742_abnormal_vestibular_system0.61930655
167MP0001944_abnormal_pancreas_morphology0.61863914
168MP0000639_abnormal_adrenal_gland0.61503755
169MP0001293_anophthalmia0.56353136
170MP0000537_abnormal_urethra_morphology0.55212427
171MP0002938_white_spotting0.55025746
172MP0002163_abnormal_gland_morphology0.54800373
173MP0005387_immune_system_phenotype0.53093409
174MP0001790_abnormal_immune_system0.53093409

Predicted human phenotypes

RankGene SetZ-score
1Progressive external ophthalmoplegia (HP:0000590)6.74634842
2Clumsiness (HP:0002312)6.05352916
3Megalencephaly (HP:0001355)5.43775547
4Muscle abnormality related to mitochondrial dysfunction (HP:0003800)5.37328869
5Breast hypoplasia (HP:0003187)4.58674541
6Birth length less than 3rd percentile (HP:0003561)4.52057331
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.16390344
8Short 1st metacarpal (HP:0010034)3.88367003
9Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.88367003
10Hematochezia (HP:0002573)3.77409995
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.73572803
12Granulocytopenia (HP:0001913)3.71247492
13Duplicated collecting system (HP:0000081)3.62823695
14Chromsome breakage (HP:0040012)3.57027022
15Stomach cancer (HP:0012126)3.45301237
16Reticulocytopenia (HP:0001896)3.41724060
17Disproportionate short-trunk short stature (HP:0003521)3.41523905
18Abnormality of the 1st metacarpal (HP:0010009)3.39708767
19External ophthalmoplegia (HP:0000544)3.38912411
20Proximal tubulopathy (HP:0000114)3.37010252
21Stenosis of the external auditory canal (HP:0000402)3.36350661
22Cerebral hypomyelination (HP:0006808)3.35862675
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.34928896
24Methylmalonic aciduria (HP:0012120)3.32302867
25Progressive muscle weakness (HP:0003323)3.30900883
26Abnormality of the renal collecting system (HP:0004742)3.16666573
27Methylmalonic acidemia (HP:0002912)3.16240291
28Abnormality of the nasal septum (HP:0000419)3.13345516
29Macrocytic anemia (HP:0001972)3.12658759
30Renal Fanconi syndrome (HP:0001994)3.11732135
31Abnormality of the proximal phalanges of the hand (HP:0009834)2.96329220
323-Methylglutaconic aciduria (HP:0003535)2.96148987
33Persistence of primary teeth (HP:0006335)2.95664015
34Pendular nystagmus (HP:0012043)2.93929173
35Congenital sensorineural hearing impairment (HP:0008527)2.85924524
36Thyroid-stimulating hormone excess (HP:0002925)2.85526766
37Increased hepatocellular lipid droplets (HP:0006565)2.83406799
38Short hallux (HP:0010109)2.81483771
39Morphological abnormality of the middle ear (HP:0008609)2.77613887
40Oligomenorrhea (HP:0000876)2.75056677
41Aplasia/Hypoplasia of the hallux (HP:0008362)2.72308464
42Congenital stationary night blindness (HP:0007642)2.71617500
43Decreased circulating renin level (HP:0003351)2.71081979
44Increased serum lactate (HP:0002151)2.69122075
45Mitochondrial inheritance (HP:0001427)2.68067578
46Exertional dyspnea (HP:0002875)2.64217831
47Aplasia/hypoplasia of the uterus (HP:0008684)2.61870094
48Congenital, generalized hypertrichosis (HP:0004540)2.57857542
49Abnormality of the preputium (HP:0100587)2.57629528
50Abolished electroretinogram (ERG) (HP:0000550)2.53725384
51Short phalanx of the thumb (HP:0009660)2.53029953
52Oligodontia (HP:0000677)2.52794290
53Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.50853772
54Synostosis of carpal bones (HP:0005048)2.49846534
55Parakeratosis (HP:0001036)2.49561814
56Abnormality of chromosome stability (HP:0003220)2.49035998
57Abnormal spermatogenesis (HP:0008669)2.48868842
58Abnormality of the middle phalanges of the toes (HP:0010183)2.48774472
59IgM deficiency (HP:0002850)2.47815305
60Acute necrotizing encephalopathy (HP:0006965)2.47053037
61Microvesicular hepatic steatosis (HP:0001414)2.46911112
62Meckel diverticulum (HP:0002245)2.44986761
63Hepatocellular necrosis (HP:0001404)2.43493216
64Acute lymphatic leukemia (HP:0006721)2.42468440
65Severe visual impairment (HP:0001141)2.41600282
66Lipid accumulation in hepatocytes (HP:0006561)2.40749597
67Adrenal hypoplasia (HP:0000835)2.39727275
68Neoplasm of the adrenal cortex (HP:0100641)2.37659484
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.35495676
70Nephronophthisis (HP:0000090)2.33583827
71Carpal bone hypoplasia (HP:0001498)2.33183584
72Exercise intolerance (HP:0003546)2.32961317
73Secondary amenorrhea (HP:0000869)2.32810493
74Eosinophilia (HP:0001880)2.32461299
75Abnormality of the phalanges of the 5th finger (HP:0004213)2.31002720
76Paralysis (HP:0003470)2.30531590
77Increased CSF lactate (HP:0002490)2.29632707
78Abnormality of the ileum (HP:0001549)2.28555518
79Abnormality of renal resorption (HP:0011038)2.28194685
80Patellar aplasia (HP:0006443)2.26436093
81Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24958007
82Small hand (HP:0200055)2.23636518
83Azoospermia (HP:0000027)2.21545717
84Megaloblastic anemia (HP:0001889)2.19164168
85Pancreatic fibrosis (HP:0100732)2.18804558
86CNS hypomyelination (HP:0003429)2.18399615
87Abnormality of the frontal sinuses (HP:0002687)2.17841788
88Pallor (HP:0000980)2.16971040
89Symphalangism affecting the phalanges of the hand (HP:0009773)2.15418124
90Fused cervical vertebrae (HP:0002949)2.15398111
91Horseshoe kidney (HP:0000085)2.14935726
92Pancytopenia (HP:0001876)2.13530129
93Bone marrow hypocellularity (HP:0005528)2.12632143
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12375121
95Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12375121
96Sclerocornea (HP:0000647)2.12168818
97Hepatic necrosis (HP:0002605)2.12040884
98Metabolic alkalosis (HP:0200114)2.11785320
99Aplasia/Hypoplasia of the patella (HP:0006498)2.11737867
100Abnormality of midbrain morphology (HP:0002418)2.10605878
101Molar tooth sign on MRI (HP:0002419)2.10605878
102Abnormality of DNA repair (HP:0003254)2.10469538
103Premature ovarian failure (HP:0008209)2.10456260
104Abnormal number of erythroid precursors (HP:0012131)2.09839933
105Acute encephalopathy (HP:0006846)2.08715269
106Abnormality of cells of the erythroid lineage (HP:0012130)2.08604430
107Keratoconus (HP:0000563)2.08471850
108Increased corneal curvature (HP:0100692)2.08471850
109Rough bone trabeculation (HP:0100670)2.07376737
110Aplasia/Hypoplasia of the uvula (HP:0010293)2.06066116
111Abnormality of eosinophils (HP:0001879)2.04899498
112True hermaphroditism (HP:0010459)2.04696495
113Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.04208341
114Ureteral duplication (HP:0000073)2.02711044
115Abnormal respiratory motile cilium morphology (HP:0005938)2.02251561
116Abnormal respiratory epithelium morphology (HP:0012253)2.02251561
117Abnormality of pyrimidine metabolism (HP:0004353)2.01262589
118Abnormality of placental membranes (HP:0011409)2.01072352
119Amniotic constriction ring (HP:0009775)2.01072352
120Absent radius (HP:0003974)2.00816803
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00669166
122Abnormality of alanine metabolism (HP:0010916)2.00669166
123Hyperalaninemia (HP:0003348)2.00669166
124Abnormality of the renal medulla (HP:0100957)2.00588794
125Abnormality of the renal cortex (HP:0011035)2.00471833
126Aplasia/Hypoplasia of the tibia (HP:0005772)2.00311604
127Abnormal drinking behavior (HP:0030082)1.99971975
128Polydipsia (HP:0001959)1.99971975
129Clubbing of toes (HP:0100760)1.99949933
130Preauricular pit (HP:0004467)1.99934734
131Periauricular skin pits (HP:0100277)1.99934734
132Progressive neurologic deterioration (HP:0002344)1.99608179
133Genu varum (HP:0002970)1.99157160
134Pancreatic cysts (HP:0001737)1.99044623
135Impulsivity (HP:0100710)1.98508630
136Humeroradial synostosis (HP:0003041)1.97533502
137Synostosis involving the elbow (HP:0003938)1.97533502
138Cellular immunodeficiency (HP:0005374)1.97430356
139Abnormal mitochondria in muscle tissue (HP:0008316)1.97170163
140Short tibia (HP:0005736)1.96815973
141Cortical visual impairment (HP:0100704)1.95956283
142Hyperglycinemia (HP:0002154)1.95153337
143CNS demyelination (HP:0007305)1.94755186
144Respiratory difficulties (HP:0002880)1.94613571
145Seborrheic dermatitis (HP:0001051)1.94121371
146Lactic acidosis (HP:0003128)1.94004167
147Asplenia (HP:0001746)1.92317905
148Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91985965
149Osteomalacia (HP:0002749)1.91985544
150Concave nail (HP:0001598)1.91342855
151Severe muscular hypotonia (HP:0006829)1.91104858
152Erythroderma (HP:0001019)1.90503062
153Maternal diabetes (HP:0009800)1.90249525
154Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90025522
155Attenuation of retinal blood vessels (HP:0007843)1.89178973
156Aplasia involving forearm bones (HP:0009822)1.89127860
157Absent forearm bone (HP:0003953)1.89127860
158Abnormal ciliary motility (HP:0012262)1.88989188
159Hypoplastic pelvis (HP:0008839)1.87921272
160Unsteady gait (HP:0002317)1.87215166
161Prostate neoplasm (HP:0100787)1.86730805
162Prolonged neonatal jaundice (HP:0006579)1.86348050
163IgG deficiency (HP:0004315)1.85363973
164Type I transferrin isoform profile (HP:0003642)1.84559662
165Glucose intolerance (HP:0000833)1.84154868
166Aplastic anemia (HP:0001915)1.82346414
167Progressive macrocephaly (HP:0004481)1.81435639
168Decreased central vision (HP:0007663)1.81127976
169Aplasia/Hypoplasia of the spleen (HP:0010451)1.81030704
170Abnormal rod and cone electroretinograms (HP:0008323)1.79236528
171Genetic anticipation (HP:0003743)1.78954259
172Ectopic kidney (HP:0000086)1.78725526
173Absent thumb (HP:0009777)1.77920811
174Triphalangeal thumb (HP:0001199)1.77261699
175Delusions (HP:0000746)1.76896050
176Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.76711107
177Panhypogammaglobulinemia (HP:0003139)1.76646236
178Type II lissencephaly (HP:0007260)1.75595108
179Lymphoma (HP:0002665)1.75240688
180Chorioretinal atrophy (HP:0000533)1.75166371
181Bulbous nose (HP:0000414)1.74724005
182Abnormality of macrophages (HP:0004311)1.74369403
183Encephalitis (HP:0002383)1.73135572
184Diastasis recti (HP:0001540)1.72944303
185Decreased subcutaneous fat (HP:0001002)1.69038354
186Cystic liver disease (HP:0006706)1.68590090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK37.22929570
2STK164.39359520
3PLK44.26816985
4MARK13.96801739
5ZAK3.93708932
6IRAK43.75653647
7BUB13.74068960
8FRK3.35188853
9IRAK23.11951080
10IRAK13.02075565
11PNCK2.69156846
12TAOK32.62752148
13WEE12.37364129
14SRPK12.16029420
15TTK1.97660603
16EPHA21.79198738
17EIF2AK11.74901923
18EIF2AK31.62471202
19TLK11.61398218
20MAPK131.59940976
21TSSK61.58255666
22PRKD21.53033917
23PHKG11.47245188
24PHKG21.47245188
25VRK11.41644142
26MAP4K21.41549629
27WNK41.32153006
28KIT1.31047208
29NUAK11.28948926
30DYRK31.26426328
31CDC71.18663238
32PRKCI1.14678700
33PLK31.11366506
34PLK11.06723952
35NME11.04831639
36ATR1.04761833
37BRD41.01746166
38MAP2K21.00826561
39PIK3CA0.99680622
40SGK20.99242251
41MST40.95043161
42TESK20.94356822
43WNK30.93115434
44MAP2K10.89786553
45MAPK150.87569429
46NEK90.86082837
47STK390.83683165
48PBK0.83439189
49FLT30.83151091
50ADRBK10.82775529
51PASK0.81331480
52OXSR10.78741121
53ACVR1B0.78541094
54RPS6KA60.76214317
55WNK10.75342384
56SYK0.72327705
57CHEK20.72278943
58BLK0.70067229
59EIF2AK20.69047448
60SGK4940.68608243
61SGK2230.68608243
62IKBKE0.68408404
63CDC42BPA0.68292555
64BRAF0.67659982
65BRSK20.64024670
66TXK0.63538772
67AURKA0.63084279
68PRKACA0.57705484
69MUSK0.57124826
70PRKCQ0.56686672
71TGFBR10.56531274
72STK38L0.56428027
73PIM20.56017185
74GRK50.55898475
75NEK60.55382197
76DAPK20.55118183
77KDR0.55063010
78BMPR1B0.54925929
79CHEK10.54697369
80STK40.54400958
81EPHA40.54281746
82CLK10.54097991
83RPS6KA50.53329441
84ARAF0.53090929
85CAMKK20.52799560
86PRKCG0.52059955
87CDK90.51698530
88AURKB0.50675800
89CSNK1G20.50575630
90ATM0.50359689
91CAMK2B0.50019047
92MAP4K10.49459756
93MAP2K60.49286895
94PINK10.48783570
95TYK20.48015160
96NTRK30.47913071
97ADRBK20.47789236
98IGF1R0.47383935
99EPHA30.47363106
100PRKCE0.47069448
101MAP3K40.47021249
102MYLK0.46960098
103CAMK10.46715993
104CSNK1A10.46646464
105RPS6KA20.46538105
106ITK0.46037419
107ABL20.45890259
108LCK0.45793608
109RPS6KL10.45074746
110RPS6KC10.45074746
111NME20.44828621
112RPS6KB20.44762966
113SGK30.44664978
114MAP3K110.44423589
115STK110.44014636
116NEK20.43839139
117CSNK1G30.43462160
118MATK0.43145167
119PRKCZ0.43074343
120INSRR0.41530706
121IKBKB0.40561787
122AKT30.40554517
123MAP3K80.40510360
124MKNK20.40505129
125DYRK20.40430281
126GRK60.40160892
127MAPK40.39865181
128CSNK1G10.39797080
129MAP3K140.39714762
130PAK30.39663664
131MAPK70.39050806
132CSNK2A20.38469534
133CSK0.38123027
134MKNK10.37669211
135CDK70.37291068
136PLK20.36582352
137CAMK2G0.35515225
138GRK70.33493079
139OBSCN0.33077674
140MARK30.32664120
141CSNK2A10.32570949
142ABL10.32405818
143PRKCA0.32270145
144TIE10.31679394
145NLK0.30329607
146PTK2B0.29916780
147FES0.29730714
148TNIK0.29384493
149SGK10.29288991
150BMPR20.28887526
151CHUK0.28743659
152CDK10.28651364
153CDK20.28321400
154CSNK1E0.24286640
155BRSK10.23176888
156SCYL20.23146060
157CAMK2D0.22679525
158TEC0.22200027
159PKN10.21316627
160PRKDC0.20304916
161MAP2K70.20049603
162BCKDK0.19216338
163LYN0.19140469
164PIM10.18362190
165STK100.14763776
166CASK0.14042739
167GRK10.13377723

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.43901441
2Proteasome_Homo sapiens_hsa030504.25371987
3Ribosome_Homo sapiens_hsa030103.72164103
4DNA replication_Homo sapiens_hsa030303.65873801
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.43401566
6Mismatch repair_Homo sapiens_hsa034303.30161849
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10959275
8Pyrimidine metabolism_Homo sapiens_hsa002403.01214890
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.82661205
10Spliceosome_Homo sapiens_hsa030402.65058810
11Fanconi anemia pathway_Homo sapiens_hsa034602.63436582
12Homologous recombination_Homo sapiens_hsa034402.52102283
13Oxidative phosphorylation_Homo sapiens_hsa001902.43663117
14Nucleotide excision repair_Homo sapiens_hsa034202.36934176
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.13658139
16One carbon pool by folate_Homo sapiens_hsa006702.01571117
17Basal transcription factors_Homo sapiens_hsa030222.01519463
18RNA transport_Homo sapiens_hsa030131.95497734
19Protein export_Homo sapiens_hsa030601.93528817
20Parkinsons disease_Homo sapiens_hsa050121.89467803
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89282306
22Morphine addiction_Homo sapiens_hsa050321.87555893
23Nicotine addiction_Homo sapiens_hsa050331.82154486
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79023787
25Huntingtons disease_Homo sapiens_hsa050161.77792248
26Base excision repair_Homo sapiens_hsa034101.77423963
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72664590
28Non-homologous end-joining_Homo sapiens_hsa034501.70362576
29Caffeine metabolism_Homo sapiens_hsa002321.69361211
30Nitrogen metabolism_Homo sapiens_hsa009101.69352920
31RNA degradation_Homo sapiens_hsa030181.67450211
32Purine metabolism_Homo sapiens_hsa002301.66600883
33Tryptophan metabolism_Homo sapiens_hsa003801.57947292
34Cell cycle_Homo sapiens_hsa041101.45580178
35Asthma_Homo sapiens_hsa053101.45465851
36Glycerolipid metabolism_Homo sapiens_hsa005611.38025587
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31609002
38Epstein-Barr virus infection_Homo sapiens_hsa051691.31597654
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31586827
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31177776
41Alzheimers disease_Homo sapiens_hsa050101.25875153
42Glutathione metabolism_Homo sapiens_hsa004801.21043425
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17924526
44p53 signaling pathway_Homo sapiens_hsa041151.16241774
45Allograft rejection_Homo sapiens_hsa053301.14939268
46Other glycan degradation_Homo sapiens_hsa005111.11753793
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.11617258
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10628224
49Cardiac muscle contraction_Homo sapiens_hsa042601.09942662
50Renin secretion_Homo sapiens_hsa049241.09849950
51Graft-versus-host disease_Homo sapiens_hsa053321.09241046
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04896041
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.01897352
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00510714
55Fat digestion and absorption_Homo sapiens_hsa049751.00300641
56Folate biosynthesis_Homo sapiens_hsa007900.97750396
57Olfactory transduction_Homo sapiens_hsa047400.97048499
58Vitamin B6 metabolism_Homo sapiens_hsa007500.92936917
59Primary immunodeficiency_Homo sapiens_hsa053400.92636052
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90382727
61Type I diabetes mellitus_Homo sapiens_hsa049400.88630470
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.86446811
63Taste transduction_Homo sapiens_hsa047420.85314942
64mRNA surveillance pathway_Homo sapiens_hsa030150.85032260
65Pentose phosphate pathway_Homo sapiens_hsa000300.83001330
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82906374
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82589855
68Cholinergic synapse_Homo sapiens_hsa047250.80743521
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80122175
70Linoleic acid metabolism_Homo sapiens_hsa005910.80060002
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79287051
72Circadian entrainment_Homo sapiens_hsa047130.78866418
73Serotonergic synapse_Homo sapiens_hsa047260.77561980
74GABAergic synapse_Homo sapiens_hsa047270.75691482
75Arachidonic acid metabolism_Homo sapiens_hsa005900.74578324
76Metabolic pathways_Homo sapiens_hsa011000.74090466
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.72929650
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72640180
79Calcium signaling pathway_Homo sapiens_hsa040200.72333799
80Histidine metabolism_Homo sapiens_hsa003400.71378003
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.70655285
82beta-Alanine metabolism_Homo sapiens_hsa004100.70581123
83Systemic lupus erythematosus_Homo sapiens_hsa053220.68759494
84Insulin secretion_Homo sapiens_hsa049110.68274148
85ABC transporters_Homo sapiens_hsa020100.67834460
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66737417
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66535227
88Vitamin digestion and absorption_Homo sapiens_hsa049770.66232357
89Glutamatergic synapse_Homo sapiens_hsa047240.64586789
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64194441
91Type II diabetes mellitus_Homo sapiens_hsa049300.62598847
92cAMP signaling pathway_Homo sapiens_hsa040240.62079314
93Sulfur relay system_Homo sapiens_hsa041220.61570696
94Arginine and proline metabolism_Homo sapiens_hsa003300.61255852
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59862067
96African trypanosomiasis_Homo sapiens_hsa051430.58820026
97Butanoate metabolism_Homo sapiens_hsa006500.56229543
98Phenylalanine metabolism_Homo sapiens_hsa003600.55254993
99Dorso-ventral axis formation_Homo sapiens_hsa043200.55032016
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53771905
101Sphingolipid metabolism_Homo sapiens_hsa006000.53732841
102Collecting duct acid secretion_Homo sapiens_hsa049660.52498602
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51743185
104Ether lipid metabolism_Homo sapiens_hsa005650.49061292
105Tyrosine metabolism_Homo sapiens_hsa003500.48848253
106Gastric acid secretion_Homo sapiens_hsa049710.47844546
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47331657
108Ovarian steroidogenesis_Homo sapiens_hsa049130.46915769
109Rheumatoid arthritis_Homo sapiens_hsa053230.46393559
110Oxytocin signaling pathway_Homo sapiens_hsa049210.45877312
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.45453225
112Herpes simplex infection_Homo sapiens_hsa051680.44731517
113Regulation of autophagy_Homo sapiens_hsa041400.44566943
114Fatty acid elongation_Homo sapiens_hsa000620.43179071
115Retinol metabolism_Homo sapiens_hsa008300.42319096
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.40084485
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38653362
118Phototransduction_Homo sapiens_hsa047440.38070743
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37382365
120Chemical carcinogenesis_Homo sapiens_hsa052040.37232686
121Viral carcinogenesis_Homo sapiens_hsa052030.35779479
122Mineral absorption_Homo sapiens_hsa049780.34710609
123Basal cell carcinoma_Homo sapiens_hsa052170.33831003
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33655981
125Selenocompound metabolism_Homo sapiens_hsa004500.32907365
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.32778826
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31517647
128Antigen processing and presentation_Homo sapiens_hsa046120.31400501
129Peroxisome_Homo sapiens_hsa041460.30536484
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.30463760
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30286794
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29619064
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.26694257
134Measles_Homo sapiens_hsa051620.25233674
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24024317
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22336186
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19759439
138Steroid biosynthesis_Homo sapiens_hsa001000.19664744
139Hematopoietic cell lineage_Homo sapiens_hsa046400.19542118
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16520677
141Vibrio cholerae infection_Homo sapiens_hsa051100.16439994
142Autoimmune thyroid disease_Homo sapiens_hsa053200.15662498
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15447489
144Oocyte meiosis_Homo sapiens_hsa041140.14324400
145Biosynthesis of amino acids_Homo sapiens_hsa012300.13385108
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13367045
147Renin-angiotensin system_Homo sapiens_hsa046140.13202221
148HTLV-I infection_Homo sapiens_hsa051660.12420151
149Sulfur metabolism_Homo sapiens_hsa009200.09634050

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