SDAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.51517866
2nuclear pore complex assembly (GO:0051292)5.43038560
3establishment of integrated proviral latency (GO:0075713)4.52840005
4DNA unwinding involved in DNA replication (GO:0006268)4.51501620
5proteasome assembly (GO:0043248)4.49640060
6IMP biosynthetic process (GO:0006188)4.42347011
7mitotic nuclear envelope disassembly (GO:0007077)4.35721123
8protein localization to kinetochore (GO:0034501)4.34740335
9pore complex assembly (GO:0046931)4.26479986
10folic acid-containing compound biosynthetic process (GO:0009396)4.09906252
11nuclear envelope disassembly (GO:0051081)4.06751979
12membrane disassembly (GO:0030397)4.06751979
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.05607478
14DNA replication initiation (GO:0006270)3.98585640
15regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.95141049
16nucleobase biosynthetic process (GO:0046112)3.94794811
17DNA strand elongation involved in DNA replication (GO:0006271)3.87922716
18DNA double-strand break processing (GO:0000729)3.86629433
19maturation of SSU-rRNA (GO:0030490)3.86593973
20DNA replication-dependent nucleosome organization (GO:0034723)3.84916605
21DNA replication-dependent nucleosome assembly (GO:0006335)3.84916605
22rRNA modification (GO:0000154)3.84712213
23mitotic metaphase plate congression (GO:0007080)3.83582075
24formation of translation preinitiation complex (GO:0001731)3.80568212
25IMP metabolic process (GO:0046040)3.80054386
26mitotic sister chromatid cohesion (GO:0007064)3.77655289
27anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.77190783
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76383806
29ribosome assembly (GO:0042255)3.74355492
30mitotic chromosome condensation (GO:0007076)3.72351370
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.71464135
32negative regulation of ligase activity (GO:0051352)3.71464135
33DNA strand elongation (GO:0022616)3.68794937
34DNA duplex unwinding (GO:0032508)3.67310449
35DNA geometric change (GO:0032392)3.65936335
36protein localization to chromosome, centromeric region (GO:0071459)3.65735614
37rRNA methylation (GO:0031167)3.63533974
38pre-miRNA processing (GO:0031054)3.63062606
39regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.61754940
40regulation of mitotic spindle checkpoint (GO:1903504)3.61754940
41mitotic spindle checkpoint (GO:0071174)3.59578876
42telomere maintenance via semi-conservative replication (GO:0032201)3.57433367
43negative regulation of DNA-dependent DNA replication (GO:2000104)3.55778069
44ribosome biogenesis (GO:0042254)3.55318345
45heterochromatin organization (GO:0070828)3.55268964
46DNA catabolic process, exonucleolytic (GO:0000738)3.53961585
47negative regulation of mitotic sister chromatid separation (GO:2000816)3.53142303
48negative regulation of sister chromatid segregation (GO:0033046)3.53142303
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.53142303
50negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.53142303
51negative regulation of mitotic sister chromatid segregation (GO:0033048)3.53142303
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.50602388
53ribosomal small subunit assembly (GO:0000028)3.50429461
54kinetochore organization (GO:0051383)3.49973400
55DNA replication checkpoint (GO:0000076)3.49191192
56regulation of histone H3-K9 methylation (GO:0051570)3.48072051
57telomere maintenance via telomerase (GO:0007004)3.47978637
58metaphase plate congression (GO:0051310)3.47551142
59purine nucleobase biosynthetic process (GO:0009113)3.47133524
60cullin deneddylation (GO:0010388)3.46674696
61establishment of viral latency (GO:0019043)3.45462297
62regulation of spindle organization (GO:0090224)3.45107918
63double-strand break repair via nonhomologous end joining (GO:0006303)3.42528439
64non-recombinational repair (GO:0000726)3.42528439
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.42356117
66mitotic sister chromatid segregation (GO:0000070)3.42082687
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39762579
68somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.39298678
69somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.39298678
70isotype switching (GO:0045190)3.39298678
71mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38210941
72spliceosomal snRNP assembly (GO:0000387)3.38168141
73histone mRNA metabolic process (GO:0008334)3.37191928
74telomere maintenance via recombination (GO:0000722)3.34092207
75sister chromatid segregation (GO:0000819)3.33686907
76regulation of translational termination (GO:0006449)3.33674925
77RNA-dependent DNA replication (GO:0006278)3.33564628
78chromatin remodeling at centromere (GO:0031055)3.33268085
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33016952
80lactate metabolic process (GO:0006089)3.32312414
81amino acid activation (GO:0043038)3.32104660
82tRNA aminoacylation (GO:0043039)3.32104660
83mitotic recombination (GO:0006312)3.31644249
84tRNA aminoacylation for protein translation (GO:0006418)3.28730690
85mitotic spindle assembly checkpoint (GO:0007094)3.28546199
86termination of RNA polymerase III transcription (GO:0006386)3.27749274
87transcription elongation from RNA polymerase III promoter (GO:0006385)3.27749274
88regulation of sister chromatid segregation (GO:0033045)3.27342140
89regulation of mitotic sister chromatid separation (GO:0010965)3.27342140
90regulation of mitotic sister chromatid segregation (GO:0033047)3.27342140
91spindle assembly checkpoint (GO:0071173)3.25459620
92regulation of DNA endoreduplication (GO:0032875)3.24331626
93positive regulation of chromosome segregation (GO:0051984)3.22539705
94signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.21401086
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.21401086
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.21401086
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20428897
98response to X-ray (GO:0010165)3.20115565
99negative regulation of histone methylation (GO:0031061)3.19761257
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19733624
101protein deneddylation (GO:0000338)3.18888561
102regulation of gene silencing by RNA (GO:0060966)3.18850723
103regulation of posttranscriptional gene silencing (GO:0060147)3.18850723
104regulation of gene silencing by miRNA (GO:0060964)3.18850723
105DNA damage response, detection of DNA damage (GO:0042769)3.18825038
106meiotic chromosome segregation (GO:0045132)3.18575398
107intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18074574
108signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18074574
109DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17998240
110regulation of cellular amino acid metabolic process (GO:0006521)3.16789580
111attachment of spindle microtubules to kinetochore (GO:0008608)3.15873357
112DNA replication-independent nucleosome organization (GO:0034724)3.15116760
113DNA replication-independent nucleosome assembly (GO:0006336)3.15116760
114CENP-A containing nucleosome assembly (GO:0034080)3.14930919
115* ribonucleoprotein complex biogenesis (GO:0022613)3.14737521
116translesion synthesis (GO:0019985)3.13098487
117regulation of mitotic spindle organization (GO:0060236)3.12988789
118nuclear envelope organization (GO:0006998)3.12419134
119signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11845567
120signal transduction involved in DNA damage checkpoint (GO:0072422)3.11845567
121pseudouridine synthesis (GO:0001522)3.10023446
122DNA conformation change (GO:0071103)3.09148963
123negative regulation of RNA splicing (GO:0033119)3.09052529
124somatic hypermutation of immunoglobulin genes (GO:0016446)3.07955830
125somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07955830
126histone H2A acetylation (GO:0043968)3.06916890
127chromatin assembly (GO:0031497)3.06890184
128regulation of helicase activity (GO:0051095)3.06797502
129establishment of chromosome localization (GO:0051303)3.06771468
130histone H4-K12 acetylation (GO:0043983)3.06616440
131dosage compensation (GO:0007549)3.06167733
132regulation of centrosome cycle (GO:0046605)3.05503414
133regulation of translational fidelity (GO:0006450)3.05331560
134telomere maintenance via telomere lengthening (GO:0010833)3.04878847
135regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03461859
136chromatin assembly or disassembly (GO:0006333)3.01645982
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01525063
138rRNA processing (GO:0006364)2.99889367
139regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99271509
140mRNA transport (GO:0051028)2.97717157
141intra-S DNA damage checkpoint (GO:0031573)2.96573988
142positive regulation of mitotic sister chromatid separation (GO:1901970)2.96291222
143positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96291222
144positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96291222
145kinetochore assembly (GO:0051382)2.95635120
146regulation of RNA export from nucleus (GO:0046831)2.94845976
147regulation of centriole replication (GO:0046599)2.93063256
148rRNA metabolic process (GO:0016072)2.92904221
149postreplication repair (GO:0006301)2.92076653
150spliceosomal tri-snRNP complex assembly (GO:0000244)2.91972854
151nucleotide-excision repair, DNA gap filling (GO:0006297)2.91905362
152histone exchange (GO:0043486)2.90203833
153RNA splicing, via transesterification reactions (GO:0000375)2.89530617
154regulation of chromosome segregation (GO:0051983)2.88943057
155mRNA splicing, via spliceosome (GO:0000398)2.88346330
156RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.88346330
157negative regulation of chromosome segregation (GO:0051985)2.87455469
158RNA export from nucleus (GO:0006405)2.87246651
159protein K6-linked ubiquitination (GO:0085020)2.87008088
160regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83621788
161spindle checkpoint (GO:0031577)2.83156916
162protein localization to chromosome (GO:0034502)2.83080594
163translational initiation (GO:0006413)2.83052618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.72431723
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.43380834
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.17137584
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.96893196
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19312937
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10565273
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08845760
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80818410
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.79093137
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70289028
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47216239
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44852013
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.44524436
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42184658
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33544548
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.23399321
17MYC_22102868_ChIP-Seq_BL_Human2.19935108
18AR_21909140_ChIP-Seq_LNCAP_Human2.19017433
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.16865453
20XRN2_22483619_ChIP-Seq_HELA_Human2.16704860
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13182443
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.07529268
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04790328
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98155558
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97483907
26VDR_23849224_ChIP-Seq_CD4+_Human1.97018733
27* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94413907
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90805781
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82346464
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80367891
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.77669331
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72751072
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70649408
34TTF2_22483619_ChIP-Seq_HELA_Human1.65176056
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.64919664
36KDM5A_27292631_Chip-Seq_BREAST_Human1.61455031
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61392637
38CIITA_25753668_ChIP-Seq_RAJI_Human1.59792144
39* SRF_21415370_ChIP-Seq_HL-1_Mouse1.57817299
40DCP1A_22483619_ChIP-Seq_HELA_Human1.57213312
41ELK1_19687146_ChIP-ChIP_HELA_Human1.56653798
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56577503
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56559480
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55530612
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.54448460
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53923306
47EWS_26573619_Chip-Seq_HEK293_Human1.53769224
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.53727820
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53631490
50* GABP_19822575_ChIP-Seq_HepG2_Human1.52593936
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48926763
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48672988
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43407527
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39733320
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38250246
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37757701
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35120510
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33016736
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33006882
60FUS_26573619_Chip-Seq_HEK293_Human1.32841947
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32152587
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31148692
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30610837
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.27626983
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25299983
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24566980
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24274841
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23685090
69ZNF274_21170338_ChIP-Seq_K562_Hela1.22923321
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22754966
71* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19865056
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19667823
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.19652590
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19605617
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19192480
76TFEB_21752829_ChIP-Seq_HELA_Human1.18755561
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18086869
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16859999
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16859999
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16859999
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14765785
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13704212
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13646134
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12022488
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11827392
86* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11405444
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11141752
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10119942
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09720752
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09303048
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09212750
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08748601
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08231434
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.06846645
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.06741225
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06218868
97VDR_21846776_ChIP-Seq_THP-1_Human1.05387058
98VDR_22108803_ChIP-Seq_LS180_Human1.04069048
99TAF15_26573619_Chip-Seq_HEK293_Human0.99699762
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97908351
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95484650
102NANOG_21062744_ChIP-ChIP_HESCs_Human0.94192637
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92521969
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89797958
105SOX2_16153702_ChIP-ChIP_HESCs_Human0.89506288
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89483966
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88887861
108* SOX17_20123909_ChIP-Seq_XEN_Mouse0.88848781
109SPI1_23547873_ChIP-Seq_NB4_Human0.88741581
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88674181
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88581750
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88147455
113EZH2_27294783_Chip-Seq_NPCs_Mouse0.87855278
114MYC_18940864_ChIP-ChIP_HL60_Human0.87366663
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86679647
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85889872
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85605842
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85574850
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85098658
120NFE2_27457419_Chip-Seq_LIVER_Mouse0.84145509
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83573202
122NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82902994
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81419452
124MYB_26560356_Chip-Seq_TH1_Human0.80389109
125P300_19829295_ChIP-Seq_ESCs_Human0.80026617
126CHD1_26751641_Chip-Seq_LNCaP_Human0.79998600
127ELF5_23300383_ChIP-Seq_T47D_Human0.78717222
128NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77790803
129UTX_26944678_Chip-Seq_JUKART_Human0.77170950
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74089443
131MYB_26560356_Chip-Seq_TH2_Human0.73664967
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72330706
133SALL4_22934838_ChIP-ChIP_CD34+_Human0.70941228
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70539027
135IRF1_19129219_ChIP-ChIP_H3396_Human0.69776144
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.66943191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.54779249
2MP0010094_abnormal_chromosome_stability4.44649081
3MP0008057_abnormal_DNA_replication4.14414365
4MP0003111_abnormal_nucleus_morphology4.07534720
5MP0004957_abnormal_blastocyst_morpholog3.87066953
6MP0003077_abnormal_cell_cycle3.69540779
7MP0008058_abnormal_DNA_repair3.13626247
8MP0010352_gastrointestinal_tract_polyps2.79168578
9MP0008877_abnormal_DNA_methylation2.77987281
10MP0008007_abnormal_cellular_replicative2.73188062
11MP0003123_paternal_imprinting2.60347379
12MP0002396_abnormal_hematopoietic_system2.59729649
13MP0009697_abnormal_copulation2.54582700
14MP0001730_embryonic_growth_arrest2.40905998
15MP0010307_abnormal_tumor_latency2.32841768
16MP0000350_abnormal_cell_proliferation2.30479407
17MP0008932_abnormal_embryonic_tissue2.06751533
18MP0006035_abnormal_mitochondrial_morpho1.95854816
19MP0005076_abnormal_cell_differentiation1.93848049
20MP0003786_premature_aging1.92667679
21MP0005380_embryogenesis_phenotype1.92553544
22MP0001672_abnormal_embryogenesis/_devel1.92553544
23MP0004808_abnormal_hematopoietic_stem1.81740201
24MP0004197_abnormal_fetal_growth/weight/1.80778638
25MP0003984_embryonic_growth_retardation1.79765168
26MP0002088_abnormal_embryonic_growth/wei1.76164951
27MP0003186_abnormal_redox_activity1.75694692
28MP0005075_abnormal_melanosome_morpholog1.75161469
29MP0001697_abnormal_embryo_size1.74196534
30MP0006036_abnormal_mitochondrial_physio1.70509507
31MP0002084_abnormal_developmental_patter1.69927101
32MP0002086_abnormal_extraembryonic_tissu1.64286716
33MP0006072_abnormal_retinal_apoptosis1.63867007
34MP0003121_genomic_imprinting1.62116810
35MP0002085_abnormal_embryonic_tissue1.60790684
36MP0002080_prenatal_lethality1.60114002
37MP0002102_abnormal_ear_morphology1.58069947
38MP0003787_abnormal_imprinting1.53235190
39MP0003567_abnormal_fetal_cardiomyocyte1.48327574
40MP0003890_abnormal_embryonic-extraembry1.47440673
41MP0000490_abnormal_crypts_of1.42845807
42MP0000372_irregular_coat_pigmentation1.41904375
43MP0000313_abnormal_cell_death1.41146548
44MP0002019_abnormal_tumor_incidence1.38641903
45MP0001529_abnormal_vocalization1.34175484
46MP0006292_abnormal_olfactory_placode1.33709261
47MP0001293_anophthalmia1.33535894
48MP0002210_abnormal_sex_determination1.32961469
49MP0002254_reproductive_system_inflammat1.32260439
50MP0003763_abnormal_thymus_physiology1.30515130
51MP0005408_hypopigmentation1.28598828
52MP0009053_abnormal_anal_canal1.24026716
53MP0009333_abnormal_splenocyte_physiolog1.22890343
54MP0000703_abnormal_thymus_morphology1.22641615
55MP0005395_other_phenotype1.20400294
56MP0002938_white_spotting1.17073121
57MP0002398_abnormal_bone_marrow1.16501105
58MP0001145_abnormal_male_reproductive1.16129176
59MP0002163_abnormal_gland_morphology1.12483779
60MP0005397_hematopoietic_system_phenotyp1.10591692
61MP0001545_abnormal_hematopoietic_system1.10591692
62MP0003705_abnormal_hypodermis_morpholog1.10427846
63MP0001929_abnormal_gametogenesis1.07528822
64MP0002722_abnormal_immune_system1.06103607
65MP0000689_abnormal_spleen_morphology1.05084652
66MP0010030_abnormal_orbit_morphology1.01815854
67MP0002090_abnormal_vision1.00452559
68MP0008789_abnormal_olfactory_epithelium0.99438068
69MP0000647_abnormal_sebaceous_gland0.98155628
70MP0005023_abnormal_wound_healing0.97467320
71MP0005379_endocrine/exocrine_gland_phen0.96799009
72MP0000371_diluted_coat_color0.96656602
73MP0002233_abnormal_nose_morphology0.96022604
74MP0000653_abnormal_sex_gland0.95209174
75MP0003566_abnormal_cell_adhesion0.95026549
76MP0009278_abnormal_bone_marrow0.92393410
77MP0009672_abnormal_birth_weight0.92332760
78MP0003119_abnormal_digestive_system0.91907041
79MP0004264_abnormal_extraembryonic_tissu0.90892934
80MP0000428_abnormal_craniofacial_morphol0.90086580
81MP0003941_abnormal_skin_development0.87502187
82MP0009703_decreased_birth_body0.86701742
83MP0002751_abnormal_autonomic_nervous0.86489891
84MP0000537_abnormal_urethra_morphology0.86353476
85MP0001881_abnormal_mammary_gland0.86163487
86MP0001915_intracranial_hemorrhage0.85624476
87MP0003718_maternal_effect0.85374662
88MP0002111_abnormal_tail_morphology0.85240739
89MP0003303_peritoneal_inflammation0.84748275
90MP0002429_abnormal_blood_cell0.83619978
91MP0003195_calcinosis0.82327584
92MP0003315_abnormal_perineum_morphology0.81455231
93MP0004147_increased_porphyrin_level0.80102823
94MP0002075_abnormal_coat/hair_pigmentati0.80068586
95MP0003221_abnormal_cardiomyocyte_apopto0.79325758
96MP0005384_cellular_phenotype0.79051140
97MP0005621_abnormal_cell_physiology0.77987383
98MP0002160_abnormal_reproductive_system0.77058874
99MP0000733_abnormal_muscle_development0.76986620
100MP0001119_abnormal_female_reproductive0.76981562
101MP0002092_abnormal_eye_morphology0.76373127
102MP0001764_abnormal_homeostasis0.75470284
103MP0001800_abnormal_humoral_immune0.75022072
104MP0000716_abnormal_immune_system0.74897183
105MP0001835_abnormal_antigen_presentation0.73259542
106MP0000569_abnormal_digit_pigmentation0.72398838
107MP0001853_heart_inflammation0.71203428
108MP0000627_abnormal_mammary_gland0.70903785
109MP0003937_abnormal_limbs/digits/tail_de0.70869558
110MP0000358_abnormal_cell_content/0.69275934
111MP0002697_abnormal_eye_size0.68475747
112MP0010234_abnormal_vibrissa_follicle0.67982773
113MP0000858_altered_metastatic_potential0.67506362
114MP0001188_hyperpigmentation0.66818906
115MP0005084_abnormal_gallbladder_morpholo0.66802630
116MP0000432_abnormal_head_morphology0.66750912
117MP0002925_abnormal_cardiovascular_devel0.66705032
118MP0005253_abnormal_eye_physiology0.66440347
119MP0003936_abnormal_reproductive_system0.65522106
120MP0003448_altered_tumor_morphology0.65168385
121MP0002452_abnormal_antigen_presenting0.65045921
122MP0004215_abnormal_myocardial_fiber0.64985595
123MP0003115_abnormal_respiratory_system0.64581119
124MP0002405_respiratory_system_inflammati0.64510057
125MP0000427_abnormal_hair_cycle0.63476172
126MP0000477_abnormal_intestine_morphology0.62542370
127MP0002653_abnormal_ependyma_morphology0.61833470
128MP0005389_reproductive_system_phenotype0.61803911
129MP0002420_abnormal_adaptive_immunity0.61527702
130MP0001286_abnormal_eye_development0.61352525
131MP0005501_abnormal_skin_physiology0.61200164
132MP0001849_ear_inflammation0.61169843
133MP0001819_abnormal_immune_cell0.61000276
134MP0005367_renal/urinary_system_phenotyp0.60612844
135MP0000516_abnormal_urinary_system0.60612844
136MP0003943_abnormal_hepatobiliary_system0.59351563
137MP0003755_abnormal_palate_morphology0.58991174
138MP0008995_early_reproductive_senescence0.58589358
139MP0003806_abnormal_nucleotide_metabolis0.58156974
140MP0003011_delayed_dark_adaptation0.57621613
141MP0003698_abnormal_male_reproductive0.55758171
142MP0002796_impaired_skin_barrier0.54926507
143MP0003699_abnormal_female_reproductive0.54052666
144MP0005391_vision/eye_phenotype0.52882866

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.98823222
2Ependymoma (HP:0002888)3.92827312
3Acute necrotizing encephalopathy (HP:0006965)3.74708067
4Medulloblastoma (HP:0002885)3.69436305
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.65550169
6Birth length less than 3rd percentile (HP:0003561)3.51372286
7Acute encephalopathy (HP:0006846)3.45111504
8Abnormal mitochondria in muscle tissue (HP:0008316)3.27735153
9Progressive macrocephaly (HP:0004481)3.23079214
10Abnormality of methionine metabolism (HP:0010901)3.21573427
11Increased CSF lactate (HP:0002490)3.18139368
12Colon cancer (HP:0003003)3.16569326
13Selective tooth agenesis (HP:0001592)3.14708716
14Abnormality of chromosome stability (HP:0003220)3.09535524
15Reticulocytopenia (HP:0001896)3.09328069
16Increased hepatocellular lipid droplets (HP:0006565)2.96860801
17Mitochondrial inheritance (HP:0001427)2.95274890
18Agnosia (HP:0010524)2.92463525
19Hepatocellular necrosis (HP:0001404)2.87605484
20Increased serum pyruvate (HP:0003542)2.85916233
21Abnormality of the labia minora (HP:0012880)2.82788688
22Rhabdomyosarcoma (HP:0002859)2.82416966
23Myelodysplasia (HP:0002863)2.79094516
24Astrocytoma (HP:0009592)2.76649205
25Abnormality of the astrocytes (HP:0100707)2.76649205
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.74955776
27Breast hypoplasia (HP:0003187)2.73253795
28Abnormality of the anterior horn cell (HP:0006802)2.73119881
29Degeneration of anterior horn cells (HP:0002398)2.73119881
30Pancreatic islet-cell hyperplasia (HP:0004510)2.71331043
31Meckel diverticulum (HP:0002245)2.71167840
32Impulsivity (HP:0100710)2.70858790
33Oral leukoplakia (HP:0002745)2.69701269
34Cerebral edema (HP:0002181)2.68708046
35Microvesicular hepatic steatosis (HP:0001414)2.65250244
36Basal cell carcinoma (HP:0002671)2.61597506
37Methylmalonic acidemia (HP:0002912)2.61164485
38Abnormality of cells of the erythroid lineage (HP:0012130)2.59850808
39Type I transferrin isoform profile (HP:0003642)2.58770990
40Abnormality of the preputium (HP:0100587)2.56810411
41Ectopic kidney (HP:0000086)2.56809307
42Abnormality of the ileum (HP:0001549)2.55952738
43Patellar aplasia (HP:0006443)2.55797174
44Hepatic necrosis (HP:0002605)2.55315875
45Volvulus (HP:0002580)2.54099535
4611 pairs of ribs (HP:0000878)2.53212746
47Abnormality of glycolysis (HP:0004366)2.52728655
48Absent thumb (HP:0009777)2.51078927
49Aplastic anemia (HP:0001915)2.50680720
50Abnormal number of incisors (HP:0011064)2.50253798
51Glioma (HP:0009733)2.49701043
52Proximal placement of thumb (HP:0009623)2.49635705
53Deviation of the thumb (HP:0009603)2.48874779
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.46591156
55Increased serum lactate (HP:0002151)2.45028515
56Increased nuchal translucency (HP:0010880)2.44894845
57Abnormal number of erythroid precursors (HP:0012131)2.42244887
58Lipid accumulation in hepatocytes (HP:0006561)2.41956454
59Amaurosis fugax (HP:0100576)2.41533876
60Prominent nose (HP:0000448)2.39732519
61Aplasia/Hypoplasia of the patella (HP:0006498)2.39301614
62Neoplasm of the oral cavity (HP:0100649)2.31589560
63Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31380709
64Short 4th metacarpal (HP:0010044)2.31380709
65Small intestinal stenosis (HP:0012848)2.31188750
66Duodenal stenosis (HP:0100867)2.31188750
673-Methylglutaconic aciduria (HP:0003535)2.30740835
68Missing ribs (HP:0000921)2.29364533
69Neoplasm of striated muscle (HP:0009728)2.28734584
70Multiple enchondromatosis (HP:0005701)2.22156873
71Carpal bone hypoplasia (HP:0001498)2.21897250
72Biliary tract neoplasm (HP:0100574)2.20042662
73Thrombocytosis (HP:0001894)2.18735344
74Abnormality of serum amino acid levels (HP:0003112)2.17166826
75Premature graying of hair (HP:0002216)2.16696238
76Leukodystrophy (HP:0002415)2.16614765
77Supernumerary spleens (HP:0009799)2.16385855
78Bone marrow hypocellularity (HP:0005528)2.14363252
79Facial hemangioma (HP:0000329)2.13917342
80Neoplasm of the pancreas (HP:0002894)2.13154426
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13042757
82Abnormality of alanine metabolism (HP:0010916)2.13042757
83Hyperalaninemia (HP:0003348)2.13042757
84Cafe-au-lait spot (HP:0000957)2.12031501
85Rough bone trabeculation (HP:0100670)2.11592586
86Squamous cell carcinoma (HP:0002860)2.10991596
87Abnormal protein glycosylation (HP:0012346)2.10742701
88Abnormal glycosylation (HP:0012345)2.10742701
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10742701
90Abnormal protein N-linked glycosylation (HP:0012347)2.10742701
91Reduced antithrombin III activity (HP:0001976)2.10287208
92Abnormal lung lobation (HP:0002101)2.09664600
93Absent radius (HP:0003974)2.08871610
94Sloping forehead (HP:0000340)2.04736912
95Lactic acidosis (HP:0003128)2.03291666
96Atresia of the external auditory canal (HP:0000413)2.01546466
97High pitched voice (HP:0001620)2.00798234
98Stenosis of the external auditory canal (HP:0000402)2.00549630
99Tracheoesophageal fistula (HP:0002575)2.00350394
100Nephroblastoma (Wilms tumor) (HP:0002667)1.97274440
101Urethral obstruction (HP:0000796)1.96285481
102Lymphoma (HP:0002665)1.94156912
103Neoplasm of the adrenal gland (HP:0100631)1.94075101
104Acute myeloid leukemia (HP:0004808)1.93522448
105Cutaneous melanoma (HP:0012056)1.92699164
106Abnormality of the duodenum (HP:0002246)1.92583149
107Abnormality of the carotid arteries (HP:0005344)1.91629818
108Abnormality of the fingertips (HP:0001211)1.91627293
109Abnormal spermatogenesis (HP:0008669)1.91555878
110Pancytopenia (HP:0001876)1.91285528
111Pelvic girdle muscle weakness (HP:0003749)1.90435299
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.89656451
113Aplasia involving forearm bones (HP:0009822)1.87430578
114Absent forearm bone (HP:0003953)1.87430578
115Gastrointestinal carcinoma (HP:0002672)1.86822758
116Malignant gastrointestinal tract tumors (HP:0006749)1.86822758
117Hyperinsulinemic hypoglycemia (HP:0000825)1.86588278
118Short thumb (HP:0009778)1.86286085
119Posterior subcapsular cataract (HP:0007787)1.86123517
120Long eyelashes (HP:0000527)1.85766794
121Sparse eyelashes (HP:0000653)1.85754979
122Cerebral hypomyelination (HP:0006808)1.85600505
123Renal Fanconi syndrome (HP:0001994)1.85233566
124Abnormality of sulfur amino acid metabolism (HP:0004339)1.85028879
125Cellular immunodeficiency (HP:0005374)1.84777787
126Respiratory failure (HP:0002878)1.84644405
127Megaloblastic anemia (HP:0001889)1.84634462
128Amniotic constriction ring (HP:0009775)1.84468966
129Abnormality of placental membranes (HP:0011409)1.84468966
130Abnormality of the calcaneus (HP:0008364)1.83839485
131Supernumerary bones of the axial skeleton (HP:0009144)1.83733889
132Spinal muscular atrophy (HP:0007269)1.83154065
133Triphalangeal thumb (HP:0001199)1.83114558
134Aplasia/hypoplasia of the humerus (HP:0006507)1.82627535
135Supernumerary ribs (HP:0005815)1.82398116
136Abnormal hair whorl (HP:0010721)1.81854816
137Neoplasm of the colon (HP:0100273)1.81798179
138Abnormality of endocrine pancreas physiology (HP:0012093)1.81732182
139Abnormality of the pancreatic islet cells (HP:0006476)1.81732182
140Embryonal renal neoplasm (HP:0011794)1.80393676
141Sensory axonal neuropathy (HP:0003390)1.79749698
142Methylmalonic aciduria (HP:0012120)1.77141590
143Median cleft lip (HP:0000161)1.77064539
144Pallor (HP:0000980)1.77000867
145Congenital, generalized hypertrichosis (HP:0004540)1.76539199
146Horseshoe kidney (HP:0000085)1.75053698
147Increased density of long bones (HP:0006392)1.74309449
148Macrocytic anemia (HP:0001972)1.72513041
149Hypoplasia of the pons (HP:0012110)1.72406568
150Trismus (HP:0000211)1.72297968
151Ovarian neoplasm (HP:0100615)1.71155949
152Prominent metopic ridge (HP:0005487)1.70884775
153Deep philtrum (HP:0002002)1.70094300
154Abnormality of the pons (HP:0007361)1.69395374
155Rib fusion (HP:0000902)1.69024666
156Exercise intolerance (HP:0003546)1.67195710
157Broad palm (HP:0001169)1.66520830
158Skin tags (HP:0010609)1.66096193
159Postnatal microcephaly (HP:0005484)1.66036682
160Abnormality of the septum pellucidum (HP:0007375)1.65899655
161Short humerus (HP:0005792)1.65086339
162Abnormality of homocysteine metabolism (HP:0010919)1.64814859
163Homocystinuria (HP:0002156)1.64814859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.52784304
2CDK123.50457465
3EEF2K3.23002730
4MST43.21881222
5WEE13.21330931
6BUB12.96086298
7TSSK62.79587371
8NEK22.70489974
9PBK2.56135934
10VRK22.52150045
11TRIM282.51607876
12SRPK12.49019837
13TTK2.34559931
14STK162.20255124
15RPS6KB22.13816921
16BRD42.10886641
17PASK2.00112390
18EIF2AK11.99385070
19ATR1.95977908
20MAP3K101.89009333
21BMPR1B1.87940907
22MKNK11.85464426
23WNK31.84305849
24ACVR1B1.83427985
25PLK11.79749628
26NEK11.78310932
27PLK31.66711793
28CDK71.63793114
29STK101.63663253
30BRSK21.63041164
31MKNK21.63012960
32PLK41.61491037
33RPS6KA41.60568314
34MAP3K121.59397019
35CHEK11.58352168
36CDK41.57298334
37TAF11.56958773
38AURKB1.56933732
39NME11.56665566
40TNIK1.55728035
41MAP4K11.50888940
42ALK1.50566627
43EIF2AK31.43676466
44MAP2K31.42073181
45TGFBR11.31638227
46MAP3K81.29598400
47CHEK21.27904220
48BCR1.27672099
49ATM1.18639161
50EPHA21.18393603
51ERBB31.16085891
52PIM11.14086817
53TLK11.12785966
54PKN21.12205630
55PAK41.08572323
56STK31.07104198
57CDK21.05813355
58STK41.05208635
59PLK21.05141837
60CDK60.96250643
61SCYL20.95229079
62DYRK30.93668386
63MTOR0.92566208
64ZAK0.92384582
65MAP4K20.90998321
66VRK10.90021015
67NME20.82543657
68CSNK1G10.81239777
69AURKA0.79728828
70ZAP700.77783921
71CDK10.77085404
72CSNK2A20.74711656
73MAP3K60.72719304
74FLT30.71628305
75MELK0.69215671
76BRSK10.66380593
77TAOK20.66266256
78ERBB40.65945387
79LATS10.65814006
80TESK20.64423847
81CSNK1G20.60243798
82CSNK1G30.59737439
83STK240.59577837
84PDK40.58250499
85PDK30.58250499
86LRRK20.57833578
87PIM20.57664637
88MAP3K40.57414556
89JAK30.56311339
90PAK20.55058731
91CSNK1E0.53931470
92PRKDC0.52972811
93CSNK2A10.52525862
94CHUK0.52047310
95CDK190.51779577
96FRK0.51313717
97PNCK0.50415512
98CSNK1A1L0.50139619
99STK390.48977227
100MAPKAPK30.48963264
101OXSR10.48042058
102CCNB10.47800980
103CLK10.46813584
104RPS6KB10.46605834
105PDK20.45673673
106MAPK140.45330518
107TXK0.44838355
108FGFR10.43204774
109MAP3K30.43110735
110MST1R0.41932962
111CSNK1D0.41582673
112NLK0.41499851
113CDK90.41332686
114MAP3K50.41309505
115GRK60.41070180
116BTK0.39446233
117AKT30.39427858
118TEC0.39266270
119MAPKAPK50.38951210
120EIF2AK20.38535685
121PAK10.36968820
122CDK30.35398817
123MARK30.33864462
124STK38L0.33356164
125TTN0.33204298
126IKBKB0.32648999
127NEK90.31117544
128MAPK10.31017193
129SIK30.30655372
130CDK80.30514068
131TESK10.30069331
132NUAK10.29975249
133AKT20.29406354
134MET0.28947945
135MINK10.28843517
136GSK3B0.28256708
137CSF1R0.28249963
138DAPK10.27864990
139GRK10.25408202
140EGFR0.25187541

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.38511124
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.11795669
3Mismatch repair_Homo sapiens_hsa034304.01555291
4Protein export_Homo sapiens_hsa030603.48833913
5RNA transport_Homo sapiens_hsa030133.38924772
6Spliceosome_Homo sapiens_hsa030403.29528410
7One carbon pool by folate_Homo sapiens_hsa006703.01683727
8Homologous recombination_Homo sapiens_hsa034402.77721620
9Base excision repair_Homo sapiens_hsa034102.76912931
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71751341
11Cell cycle_Homo sapiens_hsa041102.65508867
12Nucleotide excision repair_Homo sapiens_hsa034202.55000517
13RNA polymerase_Homo sapiens_hsa030202.42526851
14Ribosome_Homo sapiens_hsa030102.41099235
15Fanconi anemia pathway_Homo sapiens_hsa034602.30000346
16mRNA surveillance pathway_Homo sapiens_hsa030152.17523641
17Oxidative phosphorylation_Homo sapiens_hsa001902.17096067
18Non-homologous end-joining_Homo sapiens_hsa034502.12069511
19RNA degradation_Homo sapiens_hsa030182.03453340
20Proteasome_Homo sapiens_hsa030501.98945528
21Parkinsons disease_Homo sapiens_hsa050121.92494734
22Basal transcription factors_Homo sapiens_hsa030221.90158710
23Pyrimidine metabolism_Homo sapiens_hsa002401.81172957
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65845833
25Propanoate metabolism_Homo sapiens_hsa006401.56757112
26p53 signaling pathway_Homo sapiens_hsa041151.55165170
27Huntingtons disease_Homo sapiens_hsa050161.44736246
28Antigen processing and presentation_Homo sapiens_hsa046121.43910301
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43563873
30Epstein-Barr virus infection_Homo sapiens_hsa051691.32095895
31Herpes simplex infection_Homo sapiens_hsa051681.32017871
32Systemic lupus erythematosus_Homo sapiens_hsa053221.25661402
33Viral carcinogenesis_Homo sapiens_hsa052031.25213905
34Pyruvate metabolism_Homo sapiens_hsa006201.21192376
35Selenocompound metabolism_Homo sapiens_hsa004501.19848003
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19447099
37Fatty acid elongation_Homo sapiens_hsa000621.17613249
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16829414
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15998039
40Alzheimers disease_Homo sapiens_hsa050101.14656368
41Steroid biosynthesis_Homo sapiens_hsa001001.11497437
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09358909
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05057301
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02324437
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01352804
46HTLV-I infection_Homo sapiens_hsa051660.98543959
47Legionellosis_Homo sapiens_hsa051340.95190041
48MicroRNAs in cancer_Homo sapiens_hsa052060.94094000
49Thyroid cancer_Homo sapiens_hsa052160.92180474
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91952692
51Primary immunodeficiency_Homo sapiens_hsa053400.90337406
52Purine metabolism_Homo sapiens_hsa002300.88054518
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87947389
54Oocyte meiosis_Homo sapiens_hsa041140.85705107
55Small cell lung cancer_Homo sapiens_hsa052220.84345807
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82790263
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81888147
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.79416324
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78745724
60Carbon metabolism_Homo sapiens_hsa012000.72680120
61Lysine degradation_Homo sapiens_hsa003100.71967424
62Biosynthesis of amino acids_Homo sapiens_hsa012300.69866073
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69514064
64Glutathione metabolism_Homo sapiens_hsa004800.67968892
65Measles_Homo sapiens_hsa051620.67266032
66TGF-beta signaling pathway_Homo sapiens_hsa043500.66547927
67Folate biosynthesis_Homo sapiens_hsa007900.66318496
68Chronic myeloid leukemia_Homo sapiens_hsa052200.65898172
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63767020
70Colorectal cancer_Homo sapiens_hsa052100.62761571
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.62539257
72Apoptosis_Homo sapiens_hsa042100.61453209
73Hippo signaling pathway_Homo sapiens_hsa043900.60375700
74Influenza A_Homo sapiens_hsa051640.59199289
75Notch signaling pathway_Homo sapiens_hsa043300.59151636
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58820900
77Hepatitis B_Homo sapiens_hsa051610.56984387
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.56870586
79Metabolic pathways_Homo sapiens_hsa011000.56422781
80Basal cell carcinoma_Homo sapiens_hsa052170.56145116
81mTOR signaling pathway_Homo sapiens_hsa041500.55256123
82Pentose phosphate pathway_Homo sapiens_hsa000300.54814563
83Acute myeloid leukemia_Homo sapiens_hsa052210.54210681
84Viral myocarditis_Homo sapiens_hsa054160.51308283
85Leishmaniasis_Homo sapiens_hsa051400.50326355
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.50174306
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48609782
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47875315
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47569754
90T cell receptor signaling pathway_Homo sapiens_hsa046600.46276028
91Adherens junction_Homo sapiens_hsa045200.45823656
92Peroxisome_Homo sapiens_hsa041460.44099669
93Shigellosis_Homo sapiens_hsa051310.43372968
94HIF-1 signaling pathway_Homo sapiens_hsa040660.42849266
95Fatty acid metabolism_Homo sapiens_hsa012120.42761455
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42640796
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41703417
98Sulfur metabolism_Homo sapiens_hsa009200.39954672
99B cell receptor signaling pathway_Homo sapiens_hsa046620.39549869
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.39083755
101Prostate cancer_Homo sapiens_hsa052150.38158607
102Pathways in cancer_Homo sapiens_hsa052000.36382462
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35890642
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35478101
105Toxoplasmosis_Homo sapiens_hsa051450.35288774
106Alcoholism_Homo sapiens_hsa050340.35131051
107Hematopoietic cell lineage_Homo sapiens_hsa046400.34780091
108Caffeine metabolism_Homo sapiens_hsa002320.34371327
109Vitamin digestion and absorption_Homo sapiens_hsa049770.33853666
110Regulation of autophagy_Homo sapiens_hsa041400.33056000
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31843151
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31182190
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30668744
114Cardiac muscle contraction_Homo sapiens_hsa042600.30633476
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.28202840
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27688914
117Renin-angiotensin system_Homo sapiens_hsa046140.27455982
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27435537
119Pancreatic cancer_Homo sapiens_hsa052120.27261551
120TNF signaling pathway_Homo sapiens_hsa046680.27038580
121FoxO signaling pathway_Homo sapiens_hsa040680.26916244
122Proteoglycans in cancer_Homo sapiens_hsa052050.26651814
123Vitamin B6 metabolism_Homo sapiens_hsa007500.25756261
124N-Glycan biosynthesis_Homo sapiens_hsa005100.25560069
125Wnt signaling pathway_Homo sapiens_hsa043100.25553107
126Non-small cell lung cancer_Homo sapiens_hsa052230.25225549
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.25030258
128Hedgehog signaling pathway_Homo sapiens_hsa043400.24446331
129Phototransduction_Homo sapiens_hsa047440.23594040
130Retinol metabolism_Homo sapiens_hsa008300.22739902
131Butanoate metabolism_Homo sapiens_hsa006500.22572169
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22560063
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.22113296
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21885052
135Osteoclast differentiation_Homo sapiens_hsa043800.21854381
136Endometrial cancer_Homo sapiens_hsa052130.21745657
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21533187
138Bladder cancer_Homo sapiens_hsa052190.21405650
139Fatty acid degradation_Homo sapiens_hsa000710.17179030
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14565721
141Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.13909253
142Circadian rhythm_Homo sapiens_hsa047100.10995186
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.10380861
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08981501
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.08108938
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07249171
147beta-Alanine metabolism_Homo sapiens_hsa004100.06506799

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