ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.17181433
2	response to pheromone (GO:0019236)	4.80072725
3	intraciliary transport (GO:0042073)	4.77554694
4	resolution of meiotic recombination intermediates (GO:0000712)	4.48787401
5	nonmotile primary cilium assembly (GO:0035058)	4.46216948
6	indolalkylamine metabolic process (GO:0006586)	4.44208799
7	acrosome reaction (GO:0007340)	4.27414570
8	epithelial cilium movement (GO:0003351)	4.08174487
9	cellular biogenic amine biosynthetic process (GO:0042401)	4.01775372
10	ATP synthesis coupled proton transport (GO:0015986)	4.00508011
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.00508011
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.95490098
13	regulation of cilium movement (GO:0003352)	3.93678913
14	fusion of sperm to egg plasma membrane (GO:0007342)	3.88653815
15	amine biosynthetic process (GO:0009309)	3.88229572
16	centriole replication (GO:0007099)	3.87347138
17	negative regulation of inclusion body assembly (GO:0090084)	3.82969624
18	dopamine biosynthetic process (GO:0042416)	3.82323881
19	piRNA metabolic process (GO:0034587)	3.80305057
20	sperm motility (GO:0030317)	3.79702816
21	catecholamine biosynthetic process (GO:0042423)	3.73743551
22	catechol-containing compound biosynthetic process (GO:0009713)	3.73743551
23	cilium organization (GO:0044782)	3.73390834
24	exocrine pancreas development (GO:0031017)	3.73059062
25	cilium assembly (GO:0042384)	3.70836057
26	protein complex biogenesis (GO:0070271)	3.65442076
27	detection of light stimulus involved in sensory perception (GO:0050962)	3.62588882
28	detection of light stimulus involved in visual perception (GO:0050908)	3.62588882
29	photoreceptor cell maintenance (GO:0045494)	3.56970875
30	alkaloid metabolic process (GO:0009820)	3.52185730
31	RNA destabilization (GO:0050779)	3.45085845
32	platelet dense granule organization (GO:0060155)	3.40142644
33	male meiosis I (GO:0007141)	3.35947524
34	axonemal dynein complex assembly (GO:0070286)	3.35097161
35	regulation of hexokinase activity (GO:1903299)	3.33849632
36	regulation of glucokinase activity (GO:0033131)	3.33849632
37	replication fork processing (GO:0031297)	3.32097818
38	protein polyglutamylation (GO:0018095)	3.31874930
39	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.30785271
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.30785271
41	NADH dehydrogenase complex assembly (GO:0010257)	3.30785271
42	regulation of meiosis I (GO:0060631)	3.27565449
43	protein targeting to Golgi (GO:0000042)	3.24398667
44	establishment of protein localization to Golgi (GO:0072600)	3.23533471
45	behavioral response to nicotine (GO:0035095)	3.22443288
46	pyrimidine dimer repair (GO:0006290)	3.21257111
47	primary amino compound metabolic process (GO:1901160)	3.20590974
48	mitochondrial respiratory chain complex assembly (GO:0033108)	3.18289920
49	cellular ketone body metabolic process (GO:0046950)	3.16738742
50	serotonin metabolic process (GO:0042428)	3.16609755
51	positive regulation of meiosis (GO:0045836)	3.16531449
52	protein refolding (GO:0042026)	3.16472170
53	seminiferous tubule development (GO:0072520)	3.14693319
54	positive regulation of meiotic cell cycle (GO:0051446)	3.11758581
55	sequestering of actin monomers (GO:0042989)	3.11300094
56	plasma membrane fusion (GO:0045026)	3.11168682
57	centriole assembly (GO:0098534)	3.09465285
58	inner ear receptor stereocilium organization (GO:0060122)	3.08429804
59	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.07962020
60	positive regulation of mitochondrial fission (GO:0090141)	3.07095493
61	cilium movement (GO:0003341)	3.06948743
62	regulation of DNA endoreduplication (GO:0032875)	3.05234304
63	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.04483921
64	branched-chain amino acid catabolic process (GO:0009083)	3.02065276
65	cilium morphogenesis (GO:0060271)	3.00093792
66	photoreceptor cell development (GO:0042461)	2.98973160
67	protein localization to cilium (GO:0061512)	2.97078100
68	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.95005908
69	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.88890964
70	reciprocal DNA recombination (GO:0035825)	2.84968075
71	reciprocal meiotic recombination (GO:0007131)	2.84968075
72	cerebral cortex radially oriented cell migration (GO:0021799)	2.83500805
73	cornea development in camera-type eye (GO:0061303)	2.82625928
74	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.80367376
75	sperm-egg recognition (GO:0035036)	2.78161440
76	adenosine metabolic process (GO:0046085)	2.77669831
77	response to insecticide (GO:0017085)	2.76316148
78	microtubule depolymerization (GO:0007019)	2.75866282
79	ketone body metabolic process (GO:1902224)	2.74719298
80	auditory receptor cell stereocilium organization (GO:0060088)	2.73026738
81	retinal rod cell development (GO:0046548)	2.71577227
82	eye photoreceptor cell development (GO:0042462)	2.70919316
83	indole-containing compound metabolic process (GO:0042430)	2.70801829
84	meiosis I (GO:0007127)	2.70764927
85	histone H2A acetylation (GO:0043968)	2.70446907
86	toxin metabolic process (GO:0009404)	2.70325715
87	cellular component assembly involved in morphogenesis (GO:0010927)	2.69587938
88	spermatid development (GO:0007286)	2.68795368
89	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.68699911
90	protein prenylation (GO:0018342)	2.65555535
91	prenylation (GO:0097354)	2.65555535
92	negative regulation of mast cell activation (GO:0033004)	2.63939962
93	DNA methylation involved in gamete generation (GO:0043046)	2.62942464
94	regulation of microtubule-based movement (GO:0060632)	2.62181502
95	pyrimidine nucleotide catabolic process (GO:0006244)	2.62144068
96	multicellular organismal aging (GO:0010259)	2.61311441
97	nephron tubule morphogenesis (GO:0072078)	2.59442271
98	nephron epithelium morphogenesis (GO:0072088)	2.59442271
99	protein localization to Golgi apparatus (GO:0034067)	2.57458598
100	mannosylation (GO:0097502)	2.57061409

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.77631310
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.36536034
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.12755962
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.04200943
5	VDR_22108803_ChIP-Seq_LS180_Human	2.87476843
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.86377095
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.76342516
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.71403061
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.69436005
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.68366686
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.66623740
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56312789
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.55674853
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.39349896
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.20878827
16	FUS_26573619_Chip-Seq_HEK293_Human	2.18174221
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16611432
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.15279832
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.12181423
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.11455791
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.08747992
22	EWS_26573619_Chip-Seq_HEK293_Human	2.07572548
23	P300_19829295_ChIP-Seq_ESCs_Human	2.03788559
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00558994
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.95220010
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94318848
27	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.87101442
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.80876283
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.73895716
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.72236341
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.70531534
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.70347078
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.68258498
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59788164
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58380458
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57281110
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.55356400
38	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.51703622
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.50647216
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50647216
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48921365
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44034826
43	STAT3_23295773_ChIP-Seq_U87_Human	1.42129299
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41507704
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.41402226
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40594330
47	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.38135229
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37939022
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36667619
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36667619
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36118325
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35759315
53	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35393846
54	AR_25329375_ChIP-Seq_VCAP_Human	1.35089749
55	VDR_23849224_ChIP-Seq_CD4+_Human	1.34609495
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32505106
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32505106
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.31015459
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29856204
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29805647
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28280922
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.27795531
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27631404
64	TCF4_23295773_ChIP-Seq_U87_Human	1.26470323
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25468213
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25050792
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24886409
68	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.24225628
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.23034720
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.21647817
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18909086
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15038245
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14078674
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14008918
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12676205
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11892977
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10066448
78	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09204176
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09173312
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07562166
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06526261
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06139930
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05073949
84	BCAT_22108803_ChIP-Seq_LS180_Human	1.05067198
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01453742
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.01379222
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01326126
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01326126
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00460478
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98497235
91	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97278957
92	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.96750114
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.96732619
94	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.96564502
95	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96370379
96	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.95415974
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94871176
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.94799127
99	P300_18555785_Chip-Seq_ESCs_Mouse	0.93551619
100	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.92767564

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.18807968
2	MP0006292_abnormal_olfactory_placode	3.66077760
3	MP0003787_abnormal_imprinting	3.42048415
4	MP0008877_abnormal_DNA_methylation	2.80755215
5	MP0006072_abnormal_retinal_apoptosis	2.71255300
6	MP0003011_delayed_dark_adaptation	2.64731125
7	MP0005410_abnormal_fertilization	2.63593007
8	MP0003121_genomic_imprinting	2.59394580
9	MP0002160_abnormal_reproductive_system	2.47487000
10	MP0003880_abnormal_central_pattern	2.39036809
11	MP0005253_abnormal_eye_physiology	2.21443967
12	MP0005551_abnormal_eye_electrophysiolog	2.14596345
13	MP0009697_abnormal_copulation	2.13011435
14	MP0002653_abnormal_ependyma_morphology	2.06013104
15	MP0003123_paternal_imprinting	1.94940524
16	MP0002735_abnormal_chemical_nociception	1.92468674
17	MP0002938_white_spotting	1.87953903
18	MP0003698_abnormal_male_reproductive	1.84250389
19	MP0006276_abnormal_autonomic_nervous	1.78467911
20	MP0003195_calcinosis	1.78168918
21	MP0000631_abnormal_neuroendocrine_gland	1.75178773
22	MP0005646_abnormal_pituitary_gland	1.71892725
23	MP0005423_abnormal_somatic_nervous	1.68646906
24	MP0008789_abnormal_olfactory_epithelium	1.68620179
25	MP0001929_abnormal_gametogenesis	1.68240495
26	MP0002638_abnormal_pupillary_reflex	1.65276413
27	MP0005084_abnormal_gallbladder_morpholo	1.63182392
28	MP0003718_maternal_effect	1.62139848
29	MP0005389_reproductive_system_phenotype	1.57770378
30	MP0000372_irregular_coat_pigmentation	1.57205921
31	MP0003136_yellow_coat_color	1.55367712
32	MP0004145_abnormal_muscle_electrophysio	1.51162242
33	MP0009046_muscle_twitch	1.50349290
34	MP0002210_abnormal_sex_determination	1.49989064
35	MP0001986_abnormal_taste_sensitivity	1.44022073
36	MP0004142_abnormal_muscle_tone	1.44020489
37	MP0001984_abnormal_olfaction	1.37651756
38	MP0005075_abnormal_melanosome_morpholog	1.36809788
39	MP0003122_maternal_imprinting	1.34498208
40	MP0005499_abnormal_olfactory_system	1.33225785
41	MP0005394_taste/olfaction_phenotype	1.33225785
42	MP0008058_abnormal_DNA_repair	1.31010516
43	MP0002184_abnormal_innervation	1.29754237
44	MP0002928_abnormal_bile_duct	1.28640742
45	MP0004885_abnormal_endolymph	1.28618889
46	MP0001764_abnormal_homeostasis	1.27118411
47	MP0003567_abnormal_fetal_cardiomyocyte	1.25543034
48	MP0001879_abnormal_lymphatic_vessel	1.24545332
49	MP0004742_abnormal_vestibular_system	1.22620717
50	MP0010368_abnormal_lymphatic_system	1.22532068
51	MP0002272_abnormal_nervous_system	1.21996782
52	MP0000653_abnormal_sex_gland	1.21930579
53	MP0001529_abnormal_vocalization	1.20773157
54	MP0002102_abnormal_ear_morphology	1.16476170
55	MP0000778_abnormal_nervous_system	1.14678896
56	MP0001145_abnormal_male_reproductive	1.12464210
57	MP0005367_renal/urinary_system_phenotyp	1.10952214
58	MP0000516_abnormal_urinary_system	1.10952214
59	MP0002557_abnormal_social/conspecific_i	1.10780426
60	MP0000569_abnormal_digit_pigmentation	1.09525776
61	MP0003950_abnormal_plasma_membrane	1.06747516
62	MP0008995_early_reproductive_senescence	1.05398470
63	MP0002295_abnormal_pulmonary_circulatio	1.04663890
64	MP0002572_abnormal_emotion/affect_behav	1.03530587
65	MP0002752_abnormal_somatic_nervous	1.00446740
66	MP0002751_abnormal_autonomic_nervous	0.99555528
67	MP0005391_vision/eye_phenotype	0.99124909
68	MP0004043_abnormal_pH_regulation	0.98704830
69	MP0002067_abnormal_sensory_capabilities	0.97653900
70	MP0002736_abnormal_nociception_after	0.96645293
71	MP0000647_abnormal_sebaceous_gland	0.95832357
72	MP0000026_abnormal_inner_ear	0.94817657
73	MP0001486_abnormal_startle_reflex	0.94001586
74	MP0001968_abnormal_touch/_nociception	0.93357407
75	MP0010030_abnormal_orbit_morphology	0.92462270
76	MP0002161_abnormal_fertility/fecundity	0.90235095
77	MP0005645_abnormal_hypothalamus_physiol	0.89617322
78	MP0005195_abnormal_posterior_eye	0.88154280
79	MP0008872_abnormal_physiological_respon	0.83904903
80	MP0002233_abnormal_nose_morphology	0.83347154
81	MP0009745_abnormal_behavioral_response	0.83264737
82	MP0003938_abnormal_ear_development	0.82882598
83	MP0000955_abnormal_spinal_cord	0.82636259
84	MP0005083_abnormal_biliary_tract	0.80257558
85	MP0001963_abnormal_hearing_physiology	0.77776840
86	MP0001919_abnormal_reproductive_system	0.77623002
87	MP0004484_altered_response_of	0.76927423
88	MP0001324_abnormal_eye_pigmentation	0.76544425
89	MP0002132_abnormal_respiratory_system	0.74982203
90	MP0001286_abnormal_eye_development	0.74044749
91	MP0005332_abnormal_amino_acid	0.71827613
92	MP0001299_abnormal_eye_distance/	0.71675603
93	MP0001119_abnormal_female_reproductive	0.71609662
94	MP0004085_abnormal_heartbeat	0.71059139
95	MP0009379_abnormal_foot_pigmentation	0.69259488
96	MP0003755_abnormal_palate_morphology	0.67930338
97	MP0010386_abnormal_urinary_bladder	0.67298553
98	MP0003878_abnormal_ear_physiology	0.65671156
99	MP0005377_hearing/vestibular/ear_phenot	0.65671156
100	MP0000049_abnormal_middle_ear	0.64429558

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	5.60851869
2	Hypothermia (HP:0002045)	4.59620472
3	Congenital primary aphakia (HP:0007707)	3.94465862
4	Gait imbalance (HP:0002141)	3.92440522
5	Limb dystonia (HP:0002451)	3.87989697
6	Nephronophthisis (HP:0000090)	3.66809431
7	3-Methylglutaconic aciduria (HP:0003535)	3.58219740
8	Nephrogenic diabetes insipidus (HP:0009806)	3.46670427
9	Decreased central vision (HP:0007663)	3.38948966
10	Abnormality of midbrain morphology (HP:0002418)	3.33687261
11	Molar tooth sign on MRI (HP:0002419)	3.33687261
12	Renal Fanconi syndrome (HP:0001994)	3.28581456
13	Abnormal pupillary function (HP:0007686)	3.24532328
14	Retinal dysplasia (HP:0007973)	3.13558875
15	Abnormality of the renal medulla (HP:0100957)	3.12867174
16	Bony spicule pigmentary retinopathy (HP:0007737)	3.08877365
17	Increased hepatocellular lipid droplets (HP:0006565)	3.08419499
18	Type II lissencephaly (HP:0007260)	3.01797357
19	Acute necrotizing encephalopathy (HP:0006965)	3.01153281
20	Genital tract atresia (HP:0001827)	2.99045535
21	Vaginal atresia (HP:0000148)	2.98016806
22	Mitochondrial inheritance (HP:0001427)	2.96450078
23	Pancreatic cysts (HP:0001737)	2.96443369
24	Progressive macrocephaly (HP:0004481)	2.94732125
25	Hypoglycemic coma (HP:0001325)	2.84056961
26	Abolished electroretinogram (ERG) (HP:0000550)	2.78140078
27	Poor coordination (HP:0002370)	2.75536090
28	Rhinitis (HP:0012384)	2.72611717
29	Limb hypertonia (HP:0002509)	2.66378586
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.65011826
31	Abnormal respiratory motile cilium physiology (HP:0012261)	2.64708485
32	Chronic hepatic failure (HP:0100626)	2.64378184
33	Hepatic necrosis (HP:0002605)	2.59760874
34	Exertional dyspnea (HP:0002875)	2.58158942
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.54431290
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.54431290
37	Pancreatic fibrosis (HP:0100732)	2.54253380
38	True hermaphroditism (HP:0010459)	2.52824724
39	Lipid accumulation in hepatocytes (HP:0006561)	2.50870337
40	Tubulointerstitial nephritis (HP:0001970)	2.48894252
41	Abnormality of the renal cortex (HP:0011035)	2.47698266
42	Generalized aminoaciduria (HP:0002909)	2.47547227
43	Increased CSF lactate (HP:0002490)	2.46241938
44	Hyperinsulinemic hypoglycemia (HP:0000825)	2.42692943
45	Postaxial hand polydactyly (HP:0001162)	2.42374375
46	Cone-rod dystrophy (HP:0000548)	2.40961375
47	Abnormal ciliary motility (HP:0012262)	2.40348106
48	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.39264950
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.36472681
50	Acute encephalopathy (HP:0006846)	2.30326198
51	Broad foot (HP:0001769)	2.30156477
52	Abnormality of urine glucose concentration (HP:0011016)	2.29199059
53	Glycosuria (HP:0003076)	2.29199059
54	Hypoglycemic seizures (HP:0002173)	2.29173524
55	Increased intramyocellular lipid droplets (HP:0012240)	2.24004498
56	Type 2 muscle fiber atrophy (HP:0003554)	2.19033714
57	Prominent nasal bridge (HP:0000426)	2.18434407
58	Attenuation of retinal blood vessels (HP:0007843)	2.17490591
59	Intestinal atresia (HP:0011100)	2.16900386
60	Decreased testicular size (HP:0008734)	2.16802701
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.16481376
62	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.16481376
63	Exercise-induced muscle cramps (HP:0003710)	2.16420484
64	Hepatocellular necrosis (HP:0001404)	2.15369277
65	Congenital sensorineural hearing impairment (HP:0008527)	2.12928430
66	Concave nail (HP:0001598)	2.12853476
67	Congenital hepatic fibrosis (HP:0002612)	2.12748069
68	Cerebral edema (HP:0002181)	2.11986207
69	Bifid tongue (HP:0010297)	2.09683239
70	Dyschromatopsia (HP:0007641)	2.09142108
71	Polydipsia (HP:0001959)	2.07699780
72	Abnormal drinking behavior (HP:0030082)	2.07699780
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.07536211
74	Renal cortical cysts (HP:0000803)	2.05200371
75	Large for gestational age (HP:0001520)	2.04320265
76	Abnormality of renal resorption (HP:0011038)	2.01999911
77	Febrile seizures (HP:0002373)	2.01059755
78	Aplasia/Hypoplasia of the lens (HP:0008063)	1.99347168
79	Abnormal number of erythroid precursors (HP:0012131)	1.96879189
80	Specific learning disability (HP:0001328)	1.95736482
81	Optic nerve hypoplasia (HP:0000609)	1.94745098
82	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.93305753
83	Focal motor seizures (HP:0011153)	1.89653551
84	Retinitis pigmentosa (HP:0000510)	1.89175845
85	Cerebellar dysplasia (HP:0007033)	1.88790116
86	Gonadotropin excess (HP:0000837)	1.87321297
87	Left ventricular hypertrophy (HP:0001712)	1.87068083
88	Adrenal hypoplasia (HP:0000835)	1.86341757
89	Ketosis (HP:0001946)	1.85098424
90	Tubulointerstitial abnormality (HP:0001969)	1.82642842
91	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.82090214
92	Absent/shortened dynein arms (HP:0200106)	1.82090214
93	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.81523763
94	Tubular atrophy (HP:0000092)	1.81489897
95	Muscle fiber atrophy (HP:0100295)	1.79614766
96	Abnormality of macular pigmentation (HP:0008002)	1.78173312
97	Proximal tubulopathy (HP:0000114)	1.77897573
98	Ketoacidosis (HP:0001993)	1.77889673
99	Methylmalonic acidemia (HP:0002912)	1.77833804
100	Hemiparesis (HP:0001269)	1.77202626

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.65932923
2	PNCK	3.65382094
3	TRIM28	3.25096603
4	BCKDK	3.22108538
5	FRK	2.99256007
6	TNIK	2.51282623
7	WEE1	2.20381324
8	STK16	2.01330626
9	PINK1	2.00747154
10	CDK19	1.96229058
11	STK39	1.94547016
12	NUAK1	1.89351920
13	TLK1	1.87950740
14	BMPR1B	1.87180470
15	TSSK6	1.85271092
16	ACVR1B	1.79593445
17	ADRBK2	1.74300558
18	GRK1	1.56732042
19	TAF1	1.56175696
20	WNK3	1.53582486
21	EIF2AK3	1.52166788
22	NTRK3	1.51852107
23	VRK2	1.51254338
24	VRK1	1.51136982
25	BRD4	1.50403995
26	PLK2	1.47513138
27	FLT3	1.47039325
28	INSRR	1.45510150
29	PLK4	1.44641377
30	OXSR1	1.43690521
31	AKT3	1.41431929
32	TAOK3	1.30647305
33	KIT	1.27458982
34	MAPK13	1.22152820
35	TIE1	1.17770849
36	MAP3K4	1.16529233
37	MAPK15	1.09206574
38	TESK2	1.06781842
39	OBSCN	1.06660335
40	EIF2AK1	1.05422485
41	CDK3	1.03511849
42	MUSK	1.01781376
43	CSF1R	0.99201019
44	DYRK3	0.98587757
45	FGFR2	0.92847175
46	DYRK2	0.84865877
47	ERBB3	0.80708450
48	LATS1	0.79573670
49	ZAK	0.78311902
50	PIK3CA	0.77193065
51	PAK3	0.76171478
52	SRPK1	0.75293899
53	WNK4	0.74314166
54	MAPKAPK5	0.73240600
55	TEC	0.72445297
56	PRKCE	0.71671080
57	PHKG2	0.71402106
58	PHKG1	0.71402106
59	PRKCG	0.70007584
60	MAP3K9	0.67839403
61	CCNB1	0.65501497
62	DDR2	0.62642730
63	PIK3CG	0.62476349
64	MKNK2	0.60869302
65	DYRK1A	0.60365988
66	MAP2K2	0.59987637
67	SGK2	0.57117696
68	RPS6KA5	0.56819975
69	MKNK1	0.55915604
70	PLK3	0.55083944
71	TGFBR2	0.52880421
72	RPS6KA4	0.52007772
73	CHUK	0.48543346
74	FGFR1	0.47091551
75	MARK1	0.47017193
76	EPHA4	0.46258807
77	PRKACB	0.46025846
78	PRKG1	0.45234431
79	IGF1R	0.43981617
80	MYLK	0.43928902
81	PTK2B	0.43746119
82	STK3	0.43473704
83	PRKACA	0.43083834
84	NTRK2	0.42694716
85	ABL1	0.42352401
86	CAMK2A	0.40707047
87	MINK1	0.40043613
88	AURKB	0.36111378
89	IRAK2	0.35053440
90	PBK	0.35015445
91	SGK223	0.34638726
92	SGK494	0.34638726
93	CSNK2A1	0.34588017
94	CASK	0.33355033
95	BRSK2	0.30270778
96	STK24	0.30023053
97	PLK1	0.28502879
98	DYRK1B	0.26939724
99	CDK7	0.24717323
100	EPHB2	0.24471389

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.96776145
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.54460155
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.42937189
4	Parkinsons disease_Homo sapiens_hsa05012	2.70125808
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.51027383
6	Regulation of autophagy_Homo sapiens_hsa04140	2.46063445
7	Ribosome_Homo sapiens_hsa03010	2.41759849
8	Propanoate metabolism_Homo sapiens_hsa00640	2.40226238
9	Asthma_Homo sapiens_hsa05310	2.07196917
10	Phenylalanine metabolism_Homo sapiens_hsa00360	2.05276255
11	Huntingtons disease_Homo sapiens_hsa05016	2.05009483
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.99617832
13	Phototransduction_Homo sapiens_hsa04744	1.91790780
14	Butanoate metabolism_Homo sapiens_hsa00650	1.91669177
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.83518897
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.80204641
17	Basal transcription factors_Homo sapiens_hsa03022	1.80153649
18	Histidine metabolism_Homo sapiens_hsa00340	1.74839136
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65162319
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.64922890
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62669542
22	Alzheimers disease_Homo sapiens_hsa05010	1.55274329
23	Homologous recombination_Homo sapiens_hsa03440	1.51818587
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.42624405
25	Olfactory transduction_Homo sapiens_hsa04740	1.39198694
26	Peroxisome_Homo sapiens_hsa04146	1.36681015
27	Mismatch repair_Homo sapiens_hsa03430	1.35353586
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.30766391
29	Caffeine metabolism_Homo sapiens_hsa00232	1.30382376
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.22861888
31	RNA polymerase_Homo sapiens_hsa03020	1.22615300
32	Taste transduction_Homo sapiens_hsa04742	1.17365206
33	Nicotine addiction_Homo sapiens_hsa05033	1.16489173
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.13501649
35	Serotonergic synapse_Homo sapiens_hsa04726	1.08301089
36	RNA degradation_Homo sapiens_hsa03018	1.06474601
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02338893
38	RNA transport_Homo sapiens_hsa03013	1.01180567
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.97074892
40	Linoleic acid metabolism_Homo sapiens_hsa00591	0.91881922
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90295126
42	GABAergic synapse_Homo sapiens_hsa04727	0.89476164
43	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.88521546
44	Fatty acid elongation_Homo sapiens_hsa00062	0.87859494
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87144740
46	Morphine addiction_Homo sapiens_hsa05032	0.86379851
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.84269846
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82987826
49	Proteasome_Homo sapiens_hsa03050	0.82740086
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.81974978
51	Spliceosome_Homo sapiens_hsa03040	0.81773801
52	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80916006
53	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80173046
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.79973107
55	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.78345698
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77267205
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.75628053
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.72803545
59	Oocyte meiosis_Homo sapiens_hsa04114	0.70731878
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70368647
61	ABC transporters_Homo sapiens_hsa02010	0.69630361
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.68750832
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68612496
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.68207078
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.67972218
66	Metabolic pathways_Homo sapiens_hsa01100	0.67616491
67	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.65331056
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.63916791
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.63313695
70	Alcoholism_Homo sapiens_hsa05034	0.63226491
71	Base excision repair_Homo sapiens_hsa03410	0.63101178
72	Retinol metabolism_Homo sapiens_hsa00830	0.61788413
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61450533
74	Amphetamine addiction_Homo sapiens_hsa05031	0.61175508
75	Purine metabolism_Homo sapiens_hsa00230	0.60582363
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60371935
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.60337252
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60234068
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.60172323
80	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55886886
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.55109845
82	Insulin secretion_Homo sapiens_hsa04911	0.54017938
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.49584643
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48596973
85	Fatty acid degradation_Homo sapiens_hsa00071	0.47711994
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46518040
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.46101633
88	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45792965
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43934380
90	Long-term depression_Homo sapiens_hsa04730	0.43361893
91	Circadian entrainment_Homo sapiens_hsa04713	0.43345686
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42829872
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41676185
94	Renin-angiotensin system_Homo sapiens_hsa04614	0.41415832
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.40295200
96	Glutathione metabolism_Homo sapiens_hsa00480	0.37926214
97	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.37619998
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35481171
99	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.34304160
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32534652

SDAD1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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