ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	central nervous system myelination (GO:0022010)	7.12568080
2	axon ensheathment in central nervous system (GO:0032291)	7.12568080
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.43996019
4	behavioral response to nicotine (GO:0035095)	4.90017782
5	gamma-aminobutyric acid transport (GO:0015812)	4.82773438
6	cell proliferation in forebrain (GO:0021846)	4.76510311
7	negative regulation of oligodendrocyte differentiation (GO:0048715)	4.60152920
8	negative regulation of astrocyte differentiation (GO:0048712)	4.58410971
9	retinal rod cell development (GO:0046548)	4.43561932
10	regulation of meiosis I (GO:0060631)	4.43016440
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.39015193
12	cilium or flagellum-dependent cell motility (GO:0001539)	4.23432697
13	transcription from mitochondrial promoter (GO:0006390)	4.13693680
14	intracellular protein transmembrane import (GO:0044743)	3.93577500
15	protein-cofactor linkage (GO:0018065)	3.82480752
16	pattern specification involved in kidney development (GO:0061004)	3.80892139
17	axonemal dynein complex assembly (GO:0070286)	3.73108202
18	nephron epithelium morphogenesis (GO:0072088)	3.56679530
19	nephron tubule morphogenesis (GO:0072078)	3.56679530
20	epithelial cilium movement (GO:0003351)	3.54662669
21	neuronal action potential propagation (GO:0019227)	3.54249639
22	cilium movement (GO:0003341)	3.48370775
23	regulation of mesoderm development (GO:2000380)	3.48195623
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.44644511
25	detection of light stimulus involved in visual perception (GO:0050908)	3.44644511
26	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.34736885
27	protein neddylation (GO:0045116)	3.34724842
28	protein import into peroxisome matrix (GO:0016558)	3.33546727
29	meiotic chromosome segregation (GO:0045132)	3.33535031
30	ATP synthesis coupled proton transport (GO:0015986)	3.32434489
31	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.32434489
32	auditory receptor cell differentiation (GO:0042491)	3.30096209
33	negative regulation of glial cell differentiation (GO:0045686)	3.27585009
34	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.23219449
35	intracellular protein transmembrane transport (GO:0065002)	3.17747319
36	regulation of gene expression by genetic imprinting (GO:0006349)	3.12772881
37	negative regulation of epidermal cell differentiation (GO:0045605)	3.07751922
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.06690649
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.06690649
40	NADH dehydrogenase complex assembly (GO:0010257)	3.06690649
41	centriole replication (GO:0007099)	3.06534594
42	rRNA methylation (GO:0031167)	3.04243424
43	prepulse inhibition (GO:0060134)	3.02323473
44	peripheral nervous system neuron development (GO:0048935)	2.94485396
45	limb development (GO:0060173)	2.93541428
46	appendage development (GO:0048736)	2.93541428
47	regulation of Rac GTPase activity (GO:0032314)	2.90847456
48	mitochondrial RNA metabolic process (GO:0000959)	2.90014238
49	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.89219493
50	nonmotile primary cilium assembly (GO:0035058)	2.87893352
51	regulation of cell fate commitment (GO:0010453)	2.87390244
52	C4-dicarboxylate transport (GO:0015740)	2.86972408
53	alanine transport (GO:0032328)	2.85896930
54	fucose catabolic process (GO:0019317)	2.85198167
55	L-fucose metabolic process (GO:0042354)	2.85198167
56	L-fucose catabolic process (GO:0042355)	2.85198167
57	reciprocal meiotic recombination (GO:0007131)	2.84594759
58	reciprocal DNA recombination (GO:0035825)	2.84594759
59	behavioral response to cocaine (GO:0048148)	2.81230363
60	histone H2A ubiquitination (GO:0033522)	2.80690557
61	exogenous drug catabolic process (GO:0042738)	2.80256075
62	response to auditory stimulus (GO:0010996)	2.75552022
63	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.74014602
64	mechanoreceptor differentiation (GO:0042490)	2.73927199
65	peptidyl-cysteine modification (GO:0018198)	2.73480892
66	tooth mineralization (GO:0034505)	2.72445639
67	histone H2A monoubiquitination (GO:0035518)	2.68528727
68	rRNA modification (GO:0000154)	2.66931335
69	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.64635266
70	termination of RNA polymerase III transcription (GO:0006386)	2.64635266
71	protein transmembrane transport (GO:0071806)	2.64443376
72	serotonin metabolic process (GO:0042428)	2.63064647
73	neuronal stem cell maintenance (GO:0097150)	2.62261414
74	mitochondrial respiratory chain complex assembly (GO:0033108)	2.61617948
75	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.61012318
76	chaperone-mediated protein transport (GO:0072321)	2.60610778
77	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.59840403
78	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.59049736
79	neuron fate determination (GO:0048664)	2.58548284
80	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.57608828
81	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.57391862
82	genetic imprinting (GO:0071514)	2.56801674
83	positive regulation of meiosis (GO:0045836)	2.55988011
84	protein complex biogenesis (GO:0070271)	2.55445192
85	negative regulation of response to food (GO:0032096)	2.55369836
86	negative regulation of appetite (GO:0032099)	2.55369836
87	negative regulation of cell fate commitment (GO:0010454)	2.53768293
88	parturition (GO:0007567)	2.50974924
89	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.50104333
90	synaptic transmission, glutamatergic (GO:0035249)	2.48321745
91	segment specification (GO:0007379)	2.48195747
92	rRNA catabolic process (GO:0016075)	2.47813284
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.47356011
94	GPI anchor metabolic process (GO:0006505)	2.46707462
95	regulation of astrocyte differentiation (GO:0048710)	2.46102333
96	oxidative demethylation (GO:0070989)	2.45892934
97	photoreceptor cell maintenance (GO:0045494)	2.44834840
98	labyrinthine layer development (GO:0060711)	2.43417065
99	head development (GO:0060322)	2.43159144
100	organic cation transport (GO:0015695)	2.41394150

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.87968097
2	VDR_22108803_ChIP-Seq_LS180_Human	3.47562982
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.12914403
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.04397539
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.84858532
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.80616645
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.51998657
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.50291506
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.26202266
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.05066227
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04485622
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.01897321
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99054420
14	EWS_26573619_Chip-Seq_HEK293_Human	1.92899477
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88328239
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77726939
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.76266117
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.75278252
19	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.71751355
20	P300_19829295_ChIP-Seq_ESCs_Human	1.68163394
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65636876
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.62411583
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56172696
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54645729
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.53534952
26	FUS_26573619_Chip-Seq_HEK293_Human	1.51746253
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.46862626
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45528576
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.44696963
30	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43336667
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37316925
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.35981276
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.34956308
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30261215
35	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27710808
36	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27702208
37	HTT_18923047_ChIP-ChIP_STHdh_Human	1.26647264
38	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.26118798
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25907453
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.24438674
41	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.23523626
42	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.22806113
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22676891
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22676891
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.22017100
46	JUN_21703547_ChIP-Seq_K562_Human	1.21945219
47	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.20855571
48	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.20606361
49	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20329146
50	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.19194707
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18756354
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18756354
53	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18490207
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.17912654
55	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16886495
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16660254
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.15111655
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14816916
59	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.14715653
60	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.14662400
61	AR_20517297_ChIP-Seq_VCAP_Human	1.14111848
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14034551
63	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.13937904
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12537616
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.11505274
66	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.10855189
67	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.10495146
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09225678
69	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.08881524
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08443712
71	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08371954
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07632613
73	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.07321589
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06928093
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06800251
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05637140
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05250577
78	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04671076
79	STAT3_23295773_ChIP-Seq_U87_Human	1.04090562
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02918772
81	CBP_20019798_ChIP-Seq_JUKART_Human	1.02918772
82	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.02487124
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.02292098
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01235868
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01235868
86	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00000534
87	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.99921423
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98245800
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97946122
90	TCF4_23295773_ChIP-Seq_U87_Human	0.96614164
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96196619
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96110555
93	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.95887655
94	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.95819456
95	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.95618067
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95593542
97	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.94931695
98	NCOR_22424771_ChIP-Seq_293T_Human	0.94789444
99	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.94537766
100	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.93796380

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.53644026
2	MP0004885_abnormal_endolymph	3.29278816
3	MP0003693_abnormal_embryo_hatching	2.97100031
4	MP0003646_muscle_fatigue	2.75873822
5	MP0003806_abnormal_nucleotide_metabolis	2.74351055
6	MP0002102_abnormal_ear_morphology	2.64353931
7	MP0002638_abnormal_pupillary_reflex	2.56949110
8	MP0004858_abnormal_nervous_system	2.48061541
9	MP0002653_abnormal_ependyma_morphology	2.46514633
10	MP0001485_abnormal_pinna_reflex	2.35067819
11	MP0003718_maternal_effect	2.29304832
12	MP0003787_abnormal_imprinting	2.24403595
13	MP0008789_abnormal_olfactory_epithelium	2.23533123
14	MP0005551_abnormal_eye_electrophysiolog	2.03909653
15	MP0004133_heterotaxia	1.85907926
16	MP0001293_anophthalmia	1.84807434
17	MP0008877_abnormal_DNA_methylation	1.80154203
18	MP0008872_abnormal_physiological_respon	1.78725717
19	MP0001986_abnormal_taste_sensitivity	1.77590321
20	MP0001348_abnormal_lacrimal_gland	1.76132398
21	MP0005423_abnormal_somatic_nervous	1.72721752
22	MP0009745_abnormal_behavioral_response	1.72229475
23	MP0006292_abnormal_olfactory_placode	1.71359010
24	MP0004142_abnormal_muscle_tone	1.69283946
25	MP0000049_abnormal_middle_ear	1.65444320
26	MP0005499_abnormal_olfactory_system	1.65320294
27	MP0005394_taste/olfaction_phenotype	1.65320294
28	MP0002272_abnormal_nervous_system	1.63100344
29	MP0001968_abnormal_touch/_nociception	1.62059411
30	MP0005379_endocrine/exocrine_gland_phen	1.61361954
31	MP0003121_genomic_imprinting	1.55463555
32	MP0003119_abnormal_digestive_system	1.54779559
33	MP0002572_abnormal_emotion/affect_behav	1.53896410
34	MP0003890_abnormal_embryonic-extraembry	1.53187074
35	MP0000383_abnormal_hair_follicle	1.48623594
36	MP0000026_abnormal_inner_ear	1.47994986
37	MP0005645_abnormal_hypothalamus_physiol	1.42696552
38	MP0006276_abnormal_autonomic_nervous	1.41384115
39	MP0000631_abnormal_neuroendocrine_gland	1.38631260
40	MP0003123_paternal_imprinting	1.35214739
41	MP0002734_abnormal_mechanical_nocicepti	1.32933589
42	MP0004742_abnormal_vestibular_system	1.29953705
43	MP0004859_abnormal_synaptic_plasticity	1.28063664
44	MP0002160_abnormal_reproductive_system	1.27518638
45	MP0003880_abnormal_central_pattern	1.18297996
46	MP0009046_muscle_twitch	1.16900388
47	MP0008875_abnormal_xenobiotic_pharmacok	1.16316765
48	MP0010030_abnormal_orbit_morphology	1.13153996
49	MP0003937_abnormal_limbs/digits/tail_de	1.12407754
50	MP0005377_hearing/vestibular/ear_phenot	1.12091698
51	MP0003878_abnormal_ear_physiology	1.12091698
52	MP0002210_abnormal_sex_determination	1.11116494
53	MP0009379_abnormal_foot_pigmentation	1.10675853
54	MP0003635_abnormal_synaptic_transmissio	1.10182275
55	MP0001929_abnormal_gametogenesis	1.09092041
56	MP0002067_abnormal_sensory_capabilities	1.08887381
57	MP0002557_abnormal_social/conspecific_i	1.08301172
58	MP0002282_abnormal_trachea_morphology	1.08176890
59	MP0002064_seizures	1.07731104
60	MP0001963_abnormal_hearing_physiology	1.05047326
61	MP0002909_abnormal_adrenal_gland	1.04903049
62	MP0005195_abnormal_posterior_eye	1.01408778
63	MP0005389_reproductive_system_phenotype	0.99515775
64	MP0002184_abnormal_innervation	0.98863428
65	MP0002837_dystrophic_cardiac_calcinosis	0.98427295
66	MP0003938_abnormal_ear_development	0.97064677
67	MP0002138_abnormal_hepatobiliary_system	0.96183819
68	MP0001984_abnormal_olfaction	0.96060372
69	MP0002736_abnormal_nociception_after	0.95755952
70	MP0000762_abnormal_tongue_morphology	0.95475594
71	MP0002752_abnormal_somatic_nervous	0.94574967
72	MP0001486_abnormal_startle_reflex	0.93300576
73	MP0001970_abnormal_pain_threshold	0.93016075
74	MP0000427_abnormal_hair_cycle	0.92677960
75	MP0000778_abnormal_nervous_system	0.91213463
76	MP0002090_abnormal_vision	0.91204465
77	MP0000566_synostosis	0.90915207
78	MP0002063_abnormal_learning/memory/cond	0.90876861
79	MP0001440_abnormal_grooming_behavior	0.90681473
80	MP0001501_abnormal_sleep_pattern	0.89920338
81	MP0002938_white_spotting	0.89917198
82	MP0001905_abnormal_dopamine_level	0.89614597
83	MP0008058_abnormal_DNA_repair	0.87711359
84	MP0005253_abnormal_eye_physiology	0.87690947
85	MP0003698_abnormal_male_reproductive	0.87386075
86	MP0000653_abnormal_sex_gland	0.86948267
87	MP0004215_abnormal_myocardial_fiber	0.86169319
88	MP0006036_abnormal_mitochondrial_physio	0.84589408
89	MP0010678_abnormal_skin_adnexa	0.84528758
90	MP0000647_abnormal_sebaceous_gland	0.84398804
91	MP0002733_abnormal_thermal_nociception	0.82971116
92	MP0005167_abnormal_blood-brain_barrier	0.81404523
93	MP0004043_abnormal_pH_regulation	0.81088604
94	MP0001919_abnormal_reproductive_system	0.80975553
95	MP0001145_abnormal_male_reproductive	0.79422677
96	MP0005410_abnormal_fertilization	0.77672746
97	MP0008961_abnormal_basal_metabolism	0.74175078
98	MP0005365_abnormal_bile_salt	0.74090562
99	MP0003195_calcinosis	0.73186843
100	MP0008775_abnormal_heart_ventricle	0.72354459

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	4.66127713
2	Lipid accumulation in hepatocytes (HP:0006561)	4.40638673
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.36490169
4	Absent/shortened dynein arms (HP:0200106)	4.36490169
5	Abnormal respiratory motile cilium physiology (HP:0012261)	3.57872404
6	3-Methylglutaconic aciduria (HP:0003535)	3.57705239
7	Hypoplasia of the fovea (HP:0007750)	3.56123260
8	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.56123260
9	Supernumerary spleens (HP:0009799)	3.50812204
10	Congenital, generalized hypertrichosis (HP:0004540)	3.46942272
11	Renal Fanconi syndrome (HP:0001994)	3.46533870
12	Abnormal ciliary motility (HP:0012262)	3.41360516
13	Bilateral microphthalmos (HP:0007633)	3.40688338
14	Septo-optic dysplasia (HP:0100842)	3.10665062
15	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.03530353
16	Anophthalmia (HP:0000528)	3.02166117
17	Abnormality of the labia minora (HP:0012880)	3.01649865
18	Pancreatic cysts (HP:0001737)	3.00932862
19	Medial flaring of the eyebrow (HP:0010747)	2.91257929
20	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.86334012
21	Rib fusion (HP:0000902)	2.83267843
22	Increased intramyocellular lipid droplets (HP:0012240)	2.82053674
23	Abnormal respiratory epithelium morphology (HP:0012253)	2.80488964
24	Abnormal respiratory motile cilium morphology (HP:0005938)	2.80488964
25	Fused cervical vertebrae (HP:0002949)	2.70577364
26	Abnormality of the fovea (HP:0000493)	2.60789540
27	Sclerocornea (HP:0000647)	2.57016397
28	Exertional dyspnea (HP:0002875)	2.55658032
29	Methylmalonic acidemia (HP:0002912)	2.54991550
30	Bile duct proliferation (HP:0001408)	2.49485401
31	Abnormal biliary tract physiology (HP:0012439)	2.49485401
32	Gait imbalance (HP:0002141)	2.44747455
33	Mitochondrial inheritance (HP:0001427)	2.44290563
34	Brushfield spots (HP:0001088)	2.43625285
35	Nephrogenic diabetes insipidus (HP:0009806)	2.41638388
36	Pendular nystagmus (HP:0012043)	2.40494042
37	True hermaphroditism (HP:0010459)	2.39870636
38	Abnormality of renal resorption (HP:0011038)	2.37466070
39	Pancreatic fibrosis (HP:0100732)	2.37163260
40	Abnormality of midbrain morphology (HP:0002418)	2.36882363
41	Molar tooth sign on MRI (HP:0002419)	2.36882363
42	Acute necrotizing encephalopathy (HP:0006965)	2.36765977
43	Increased CSF lactate (HP:0002490)	2.35960056
44	Increased muscle lipid content (HP:0009058)	2.35398131
45	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.33195697
46	Congenital primary aphakia (HP:0007707)	2.32088987
47	Type II lissencephaly (HP:0007260)	2.31964050
48	Methylmalonic aciduria (HP:0012120)	2.29417919
49	Polydipsia (HP:0001959)	2.27163694
50	Abnormal drinking behavior (HP:0030082)	2.27163694
51	Nephronophthisis (HP:0000090)	2.26996707
52	Abnormality of the right ventricle (HP:0001707)	2.26720930
53	Tubular atrophy (HP:0000092)	2.26037216
54	Vaginal atresia (HP:0000148)	2.23709609
55	Congenital stationary night blindness (HP:0007642)	2.23231995
56	Hyperglycinemia (HP:0002154)	2.20700053
57	Respiratory difficulties (HP:0002880)	2.19557784
58	Aplasia/Hypoplasia of the macula (HP:0008059)	2.18557415
59	Polyphagia (HP:0002591)	2.12642220
60	Genital tract atresia (HP:0001827)	2.12188791
61	Absent septum pellucidum (HP:0001331)	2.11813914
62	Vertebral fusion (HP:0002948)	2.10929620
63	Abnormality of the renal cortex (HP:0011035)	2.10090139
64	Concave nail (HP:0001598)	2.09777453
65	Glycosuria (HP:0003076)	2.09687113
66	Abnormality of urine glucose concentration (HP:0011016)	2.09687113
67	Small hand (HP:0200055)	2.08595661
68	Abnormality of the pons (HP:0007361)	2.07999540
69	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.03791307
70	Polyuria (HP:0000103)	2.02971268
71	Hyperglycinuria (HP:0003108)	1.99883232
72	Optic nerve hypoplasia (HP:0000609)	1.99352377
73	Acute encephalopathy (HP:0006846)	1.98672774
74	Chronic bronchitis (HP:0004469)	1.97530913
75	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.94913187
76	Adrenal hypoplasia (HP:0000835)	1.91465771
77	Hypoplasia of the pons (HP:0012110)	1.91191099
78	Abnormality of the renal medulla (HP:0100957)	1.90565797
79	Hyperphosphaturia (HP:0003109)	1.89387009
80	Progressive macrocephaly (HP:0004481)	1.89142770
81	Abnormal mitochondria in muscle tissue (HP:0008316)	1.88586379
82	Metabolic alkalosis (HP:0200114)	1.88134953
83	Hyperventilation (HP:0002883)	1.85824593
84	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.85426408
85	Rhinitis (HP:0012384)	1.85280623
86	Large for gestational age (HP:0001520)	1.85169050
87	Severe global developmental delay (HP:0011344)	1.84844880
88	Aplasia cutis congenita (HP:0001057)	1.83430877
89	Progressive microcephaly (HP:0000253)	1.82390847
90	Lissencephaly (HP:0001339)	1.81294376
91	Inability to walk (HP:0002540)	1.80754882
92	Abolished electroretinogram (ERG) (HP:0000550)	1.79853461
93	Cystic liver disease (HP:0006706)	1.78102396
94	Abnormality of the septum pellucidum (HP:0007375)	1.77090535
95	Hypoplasia of the ulna (HP:0003022)	1.76804882
96	Long nose (HP:0003189)	1.76606602
97	Adactyly (HP:0009776)	1.74507959
98	Posterior subcapsular cataract (HP:0007787)	1.74465740
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.73624788
100	Amelogenesis imperfecta (HP:0000705)	1.72976828

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.01347083
2	STK16	3.87931920
3	BMPR1B	3.52834575
4	NTRK2	3.34194283
5	TAF1	2.87881571
6	TSSK6	2.73165106
7	ZAK	2.72219173
8	PINK1	2.52473673
9	PBK	2.48584664
10	TLK1	2.35115551
11	WNK3	2.25654749
12	MAP3K9	2.25477047
13	FRK	2.22041487
14	ADRBK2	1.86521286
15	NUAK1	1.82876001
16	WEE1	1.79764250
17	EIF2AK1	1.77353874
18	TNIK	1.77085976
19	MAP2K7	1.75040317
20	MUSK	1.67679006
21	VRK2	1.64827693
22	VRK1	1.62129206
23	MAP3K4	1.59741650
24	CASK	1.51837290
25	PLK3	1.40552544
26	SIK2	1.36909059
27	GRK1	1.32890880
28	LATS1	1.32767712
29	PLK2	1.30994222
30	PLK4	1.30680877
31	NME2	1.27779609
32	PRKD3	1.26927648
33	WNK4	1.25695774
34	MAPK13	1.16296835
35	MKNK2	1.15541842
36	NTRK3	1.15033794
37	CSNK1G2	1.12981571
38	FGR	1.11048762
39	CDC7	1.07472537
40	PRKCG	1.06478136
41	PHKG2	1.04485667
42	PHKG1	1.04485667
43	MET	1.02295297
44	SRPK1	1.02164321
45	EIF2AK3	1.01872813
46	DYRK2	1.01204170
47	MKNK1	0.91231674
48	ARAF	0.91221186
49	MAPK15	0.87642359
50	NEK2	0.86621273
51	EPHB2	0.86509278
52	PTK2B	0.84262392
53	CSNK1G1	0.78527470
54	PIK3CA	0.77556567
55	STK3	0.73685222
56	MST4	0.71356606
57	PDK2	0.70710532
58	CSNK1G3	0.69078723
59	PLK1	0.65513540
60	INSRR	0.63123257
61	TIE1	0.62665172
62	MAPKAPK5	0.60596903
63	MAP3K13	0.59936783
64	OXSR1	0.58288889
65	TTK	0.57394833
66	CSNK1A1L	0.56683094
67	PKN1	0.54728176
68	MAP2K4	0.53630662
69	MAP3K6	0.52773064
70	PRKCE	0.50885400
71	DYRK1A	0.49907496
72	NEK1	0.49130790
73	CDK19	0.47007283
74	BMX	0.45510898
75	PIM2	0.44316343
76	CAMK2A	0.43980640
77	TEC	0.41768598
78	FES	0.41767798
79	STK39	0.38711654
80	EPHA4	0.37790914
81	CDK5	0.35723700
82	ADRBK1	0.34227610
83	ERBB2	0.34214925
84	CSNK1E	0.33870015
85	CSNK2A1	0.31270364
86	STK11	0.28980215
87	CSNK1D	0.28933172
88	CSNK1A1	0.28803842
89	ATR	0.28301040
90	DAPK2	0.26724981
91	MOS	0.25161690
92	DYRK3	0.24125748
93	PRKCZ	0.23768313
94	PRKCI	0.23004397
95	FGFR1	0.22874322
96	PRKCH	0.21981766
97	PRKACA	0.21881387
98	PRKCA	0.20816099
99	EPHA3	0.20169839
100	GSK3A	0.20011764

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.21213482
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.91055700
3	Nicotine addiction_Homo sapiens_hsa05033	2.77228855
4	Parkinsons disease_Homo sapiens_hsa05012	2.66729557
5	Ribosome_Homo sapiens_hsa03010	2.49266481
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.37232159
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.35485997
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.34519872
9	Basal transcription factors_Homo sapiens_hsa03022	2.19870500
10	Protein export_Homo sapiens_hsa03060	2.18133898
11	Huntingtons disease_Homo sapiens_hsa05016	2.12925929
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98919981
13	Phototransduction_Homo sapiens_hsa04744	1.95052148
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.89141926
15	Caffeine metabolism_Homo sapiens_hsa00232	1.87196921
16	RNA polymerase_Homo sapiens_hsa03020	1.83135935
17	Alzheimers disease_Homo sapiens_hsa05010	1.82040630
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.80235386
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.76786874
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76341526
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.70475656
22	Morphine addiction_Homo sapiens_hsa05032	1.64146309
23	Homologous recombination_Homo sapiens_hsa03440	1.61663549
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.60602539
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.57845961
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55900461
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.48512114
28	Olfactory transduction_Homo sapiens_hsa04740	1.47528123
29	Propanoate metabolism_Homo sapiens_hsa00640	1.42467856
30	GABAergic synapse_Homo sapiens_hsa04727	1.39911372
31	Steroid biosynthesis_Homo sapiens_hsa00100	1.30210097
32	Sulfur relay system_Homo sapiens_hsa04122	1.21120821
33	RNA degradation_Homo sapiens_hsa03018	1.20465857
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.17490413
35	One carbon pool by folate_Homo sapiens_hsa00670	1.16809821
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.15885640
37	Proteasome_Homo sapiens_hsa03050	1.15796092
38	Peroxisome_Homo sapiens_hsa04146	1.14392884
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.13915353
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.13043895
41	Pentose phosphate pathway_Homo sapiens_hsa00030	1.06937910
42	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.03093458
43	Taste transduction_Homo sapiens_hsa04742	1.01106120
44	Folate biosynthesis_Homo sapiens_hsa00790	0.98966862
45	Asthma_Homo sapiens_hsa05310	0.98550201
46	Retinol metabolism_Homo sapiens_hsa00830	0.97039074
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.96572572
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.95547927
49	RNA transport_Homo sapiens_hsa03013	0.93079604
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92634271
51	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.91710588
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.88580220
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83195797
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.81034188
55	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.80869536
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.80013967
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.79980284
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78936641
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.76918835
60	Spliceosome_Homo sapiens_hsa03040	0.75800132
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.75621474
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75498205
63	Insulin secretion_Homo sapiens_hsa04911	0.74740173
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73744309
65	Butanoate metabolism_Homo sapiens_hsa00650	0.70818082
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.69342313
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68453151
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68224586
69	Metabolic pathways_Homo sapiens_hsa01100	0.66856628
70	Hippo signaling pathway_Homo sapiens_hsa04390	0.66445211
71	Regulation of autophagy_Homo sapiens_hsa04140	0.66106374
72	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.65948200
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65439772
74	Gastric acid secretion_Homo sapiens_hsa04971	0.64144297
75	Purine metabolism_Homo sapiens_hsa00230	0.63971380
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63063114
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62674462
78	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60867861
79	Serotonergic synapse_Homo sapiens_hsa04726	0.60261388
80	Mineral absorption_Homo sapiens_hsa04978	0.58295310
81	Cocaine addiction_Homo sapiens_hsa05030	0.58214519
82	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.56195095
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54669497
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51859901
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.49925862
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48736343
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48023782
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.46736048
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46256533
90	Circadian entrainment_Homo sapiens_hsa04713	0.46118468
91	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.42456416
92	DNA replication_Homo sapiens_hsa03030	0.42156790
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41877632
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39427811
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.39019538
96	Non-homologous end-joining_Homo sapiens_hsa03450	0.37488912
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.36209458
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.35400479
99	PPAR signaling pathway_Homo sapiens_hsa03320	0.34441116
100	Histidine metabolism_Homo sapiens_hsa00340	0.34257150

SDAD1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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