SDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.04927478
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.04927478
3L-phenylalanine metabolic process (GO:0006558)5.73549953
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.73549953
5aromatic amino acid family catabolic process (GO:0009074)5.26450182
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07902249
7negative regulation of fibrinolysis (GO:0051918)4.96997927
8bile acid biosynthetic process (GO:0006699)4.83284414
9alpha-linolenic acid metabolic process (GO:0036109)4.79103952
10protein carboxylation (GO:0018214)4.79007022
11peptidyl-glutamic acid carboxylation (GO:0017187)4.79007022
12regulation of fibrinolysis (GO:0051917)4.71489434
13glyoxylate metabolic process (GO:0046487)4.71363833
14regulation of protein activation cascade (GO:2000257)4.67481695
15indole-containing compound catabolic process (GO:0042436)4.58340751
16indolalkylamine catabolic process (GO:0046218)4.58340751
17tryptophan catabolic process (GO:0006569)4.58340751
18kynurenine metabolic process (GO:0070189)4.50631905
19sulfur amino acid catabolic process (GO:0000098)4.48205407
20regulation of apoptotic cell clearance (GO:2000425)4.47788232
21regulation of complement activation (GO:0030449)4.45766875
22complement activation, alternative pathway (GO:0006957)4.38278539
23high-density lipoprotein particle remodeling (GO:0034375)4.37324276
24tryptophan metabolic process (GO:0006568)4.34239500
25homocysteine metabolic process (GO:0050667)4.32934426
26cysteine metabolic process (GO:0006534)4.32065879
27tyrosine metabolic process (GO:0006570)4.20040146
28oligosaccharide catabolic process (GO:0009313)4.18863342
29urea cycle (GO:0000050)4.11389385
30urea metabolic process (GO:0019627)4.11389385
31keratan sulfate catabolic process (GO:0042340)4.07012541
32reverse cholesterol transport (GO:0043691)4.05811382
33fat-soluble vitamin biosynthetic process (GO:0042362)4.01225868
34cellular glucuronidation (GO:0052695)4.00060616
35regulation of cholesterol storage (GO:0010885)3.98519360
36bile acid metabolic process (GO:0008206)3.98498322
37very-low-density lipoprotein particle assembly (GO:0034379)3.88230876
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.86753470
39serine family amino acid catabolic process (GO:0009071)3.86472629
40lysine metabolic process (GO:0006553)3.86249833
41lysine catabolic process (GO:0006554)3.86249833
42protein-lipid complex remodeling (GO:0034368)3.86191919
43macromolecular complex remodeling (GO:0034367)3.86191919
44plasma lipoprotein particle remodeling (GO:0034369)3.86191919
45aromatic amino acid family metabolic process (GO:0009072)3.85816293
46regulation of cholesterol esterification (GO:0010872)3.84893104
47epoxygenase P450 pathway (GO:0019373)3.84621411
48positive regulation of fatty acid beta-oxidation (GO:0032000)3.83107731
49amino-acid betaine metabolic process (GO:0006577)3.82049006
50glycosphingolipid catabolic process (GO:0046479)3.81982773
51nitrogen cycle metabolic process (GO:0071941)3.74896679
52apoptotic cell clearance (GO:0043277)3.74151515
53fibrinolysis (GO:0042730)3.72628494
54cellular modified amino acid catabolic process (GO:0042219)3.70993025
55coenzyme catabolic process (GO:0009109)3.68876282
56regulation of plasminogen activation (GO:0010755)3.68565995
57regulation of mononuclear cell migration (GO:0071675)3.67903750
58alpha-amino acid catabolic process (GO:1901606)3.67776268
59negative regulation of protein activation cascade (GO:2000258)3.67363924
60glutamate metabolic process (GO:0006536)3.64859345
61protein-lipid complex assembly (GO:0065005)3.64001151
62cellular ketone body metabolic process (GO:0046950)3.63958018
63glucuronate metabolic process (GO:0019585)3.62687075
64uronic acid metabolic process (GO:0006063)3.62687075
65regulation of triglyceride catabolic process (GO:0010896)3.57561818
66acylglycerol homeostasis (GO:0055090)3.56481272
67triglyceride homeostasis (GO:0070328)3.56481272
68positive regulation of extracellular matrix organization (GO:1903055)3.53899075
69low-density lipoprotein particle remodeling (GO:0034374)3.51048060
70plasma lipoprotein particle organization (GO:0071827)3.47413150
71cellular amino acid catabolic process (GO:0009063)3.46829179
72positive regulation of lipoprotein lipase activity (GO:0051006)3.46790405
73positive regulation of triglyceride lipase activity (GO:0061365)3.46790405
74ethanol oxidation (GO:0006069)3.43841728
75glycolipid catabolic process (GO:0019377)3.43304704
76negative regulation of sterol transport (GO:0032372)3.42421876
77negative regulation of cholesterol transport (GO:0032375)3.42421876
78collagen fibril organization (GO:0030199)3.41398511
79bile acid and bile salt transport (GO:0015721)3.40801945
80protein-lipid complex subunit organization (GO:0071825)3.39401228
81opsonization (GO:0008228)3.39207367
82plasma lipoprotein particle clearance (GO:0034381)3.38891180
83positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.38239041
84dicarboxylic acid biosynthetic process (GO:0043650)3.36235655
85benzene-containing compound metabolic process (GO:0042537)3.35957696
86chondrocyte proliferation (GO:0035988)3.35658404
87cell adhesion mediated by integrin (GO:0033627)3.35410176
88low-density lipoprotein particle clearance (GO:0034383)3.33077914
89indolalkylamine metabolic process (GO:0006586)3.32594682
90endodermal cell differentiation (GO:0035987)3.31370619
91blood coagulation, intrinsic pathway (GO:0007597)3.30674749
92phospholipid efflux (GO:0033700)3.30206022
93positive regulation of fatty acid oxidation (GO:0046321)3.27274061
94short-chain fatty acid metabolic process (GO:0046459)3.27208255
95positive regulation of lipid catabolic process (GO:0050996)3.21730541
96regulation of cholesterol homeostasis (GO:2000188)3.20381611
97arginine metabolic process (GO:0006525)3.18369911
98positive regulation of blood coagulation (GO:0030194)3.18076330
99positive regulation of hemostasis (GO:1900048)3.18076330
100cholesterol efflux (GO:0033344)3.16847796
101neuron projection extension involved in neuron projection guidance (GO:1902284)3.16243916
102axon extension involved in axon guidance (GO:0048846)3.16243916
103drug catabolic process (GO:0042737)3.15088789
104ketone body metabolic process (GO:1902224)3.14738491
105negative regulation of complement activation (GO:0045916)3.13281849
106positive regulation of coagulation (GO:0050820)3.12606336
107amine catabolic process (GO:0009310)3.11984203
108cellular biogenic amine catabolic process (GO:0042402)3.11984203
109retina vasculature morphogenesis in camera-type eye (GO:0061299)3.10407183
110regulation of fatty acid beta-oxidation (GO:0031998)3.09735224
111aldehyde catabolic process (GO:0046185)3.07028179
112midgut development (GO:0007494)3.05161785
113imidazole-containing compound metabolic process (GO:0052803)3.04186801
114serine family amino acid metabolic process (GO:0009069)3.03747020
115carboxylic acid catabolic process (GO:0046395)3.02720286
116organic acid catabolic process (GO:0016054)3.02720286
117complement activation (GO:0006956)3.01544443
118complement activation, classical pathway (GO:0006958)2.99713379
119regulation of bile acid biosynthetic process (GO:0070857)2.99283380
120ceramide catabolic process (GO:0046514)2.99028115
121G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.98973102
122plasma lipoprotein particle assembly (GO:0034377)2.98553289
123regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.98167132
124basement membrane organization (GO:0071711)2.96808854
125lipoprotein metabolic process (GO:0042157)2.96230027
126barbed-end actin filament capping (GO:0051016)2.94822776
127negative regulation of lipase activity (GO:0060192)2.94522565
128glycine metabolic process (GO:0006544)2.94164330
129carnitine metabolic process (GO:0009437)2.93530414
130acetyl-CoA metabolic process (GO:0006084)2.93053125
131positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.92354163
132protein activation cascade (GO:0072376)2.91540793
133alkaloid metabolic process (GO:0009820)2.90441118
134monocarboxylic acid catabolic process (GO:0072329)2.90251957
135aspartate family amino acid catabolic process (GO:0009068)2.89754048
136negative regulation of lipid transport (GO:0032369)2.88424896
137membrane lipid catabolic process (GO:0046466)2.87539748
138negative regulation of blood coagulation (GO:0030195)2.85300355
139negative regulation of hemostasis (GO:1900047)2.85300355
140collagen metabolic process (GO:0032963)2.83673525
141regulation of macrophage chemotaxis (GO:0010758)2.80302636
142collagen catabolic process (GO:0030574)2.78640883
143vitamin D metabolic process (GO:0042359)2.77918989
144negative regulation of coagulation (GO:0050819)2.77912735
145protein retention in ER lumen (GO:0006621)2.77603965
146acute-phase response (GO:0006953)2.75700669
147paraxial mesoderm development (GO:0048339)2.75169082
148sterol transport (GO:0015918)2.71588777
149cholesterol transport (GO:0030301)2.71588777
150sphingolipid catabolic process (GO:0030149)2.70472693
151skin morphogenesis (GO:0043589)2.69769902
152negative regulation of wound healing (GO:0061045)2.69072512
153craniofacial suture morphogenesis (GO:0097094)2.67405335
154positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.65398684
155cellular response to thyroid hormone stimulus (GO:0097067)2.64321299
156maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63172810
157multicellular organismal macromolecule metabolic process (GO:0044259)2.62213822
158regulation of heterotypic cell-cell adhesion (GO:0034114)2.62106424
159omega-hydroxylase P450 pathway (GO:0097267)2.60049793
160positive regulation of cholesterol efflux (GO:0010875)2.58843378
161glial cell migration (GO:0008347)2.57356214
162pinocytosis (GO:0006907)2.53586609
163cell proliferation involved in metanephros development (GO:0072203)2.52672967
164glomerular basement membrane development (GO:0032836)2.52161536
1654-hydroxyproline metabolic process (GO:0019471)2.52005309
166positive regulation of fatty acid biosynthetic process (GO:0045723)2.51921204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.02564628
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.68549740
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.67748963
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.57283458
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.19215596
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.48504413
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.37204934
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.29654260
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.09147102
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.72377610
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.55619266
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50051431
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.43025222
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.39936007
15* CLOCK_20551151_ChIP-Seq_293T_Human2.29501342
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.17291917
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90887604
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87932595
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.81466070
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77864791
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.74104442
22NRF2_20460467_ChIP-Seq_MEFs_Mouse1.74104442
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73906774
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64773440
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64032353
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60720817
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54897518
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.53540110
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48481690
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46163094
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43805338
32* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43644396
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43184280
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.42646880
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40776555
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39018024
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38586532
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38412763
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34821266
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33855725
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31874065
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.31135807
43* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29790646
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.29034560
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28485121
46* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27898085
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27676723
48* CJUN_26792858_Chip-Seq_BT549_Human1.27331595
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26644253
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25568166
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22703821
52GBX2_23144817_ChIP-Seq_PC3_Human1.19331442
53* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17203239
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16733727
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15564116
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15564116
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15252847
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15006006
59TP53_18474530_ChIP-ChIP_U2OS_Human1.14818529
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.14758176
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14397161
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13962155
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.13737200
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13531991
65ISL1_27105846_Chip-Seq_CPCs_Mouse1.13341650
66BCAT_22108803_ChIP-Seq_LS180_Human1.12793354
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11381173
68HTT_18923047_ChIP-ChIP_STHdh_Human1.10878720
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.09521122
70ZNF263_19887448_ChIP-Seq_K562_Human1.07880056
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07194456
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04978848
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04403469
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02823189
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02310564
76SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01063413
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98463003
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98289741
79ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97829764
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96394590
81* HNF4A_19822575_ChIP-Seq_HepG2_Human0.96296962
82AR_21572438_ChIP-Seq_LNCaP_Human0.95053618
83* SA1_22415368_ChIP-Seq_MEFs_Mouse0.94924071
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94412837
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93660129
86PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92678137
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91498473
88JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91386533
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90801479
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90514733
91SOX2_20726797_ChIP-Seq_SW620_Human0.90014460
92TP53_16413492_ChIP-PET_HCT116_Human0.88224661
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88071552
94* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87024701
95RING1B_27294783_Chip-Seq_ESCs_Mouse0.86235746
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.86012479
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85806477
98AR_21909140_ChIP-Seq_LNCAP_Human0.85698153
99TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85392923
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85267941
101IRF8_27001747_Chip-Seq_BMDM_Mouse0.85150053
102TP53_20018659_ChIP-ChIP_R1E_Mouse0.84808625
103ESR1_20079471_ChIP-ChIP_T-47D_Human0.84198386
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83899949
105KDM2B_26808549_Chip-Seq_K562_Human0.83680809
106GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83413367
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83117178
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82657098
109TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82574761
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.82565910
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82446828
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82146117
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82125071
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76197050
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.75673728
116RXR_22108803_ChIP-Seq_LS180_Human0.73709902
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72115547
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.71510629
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.71197586
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.69598967
121* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68909939
122CTBP2_25329375_ChIP-Seq_LNCAP_Human0.68608653
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.68544207
124EZH2_27304074_Chip-Seq_ESCs_Mouse0.68442576
125TP63_23658742_ChIP-Seq_EP156T_Human0.68243424
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.68208860
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.67018834
128BRD4_25478319_ChIP-Seq_HGPS_Human0.66833016
129JARID2_20064375_ChIP-Seq_MESCs_Mouse0.66236687
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.66134624
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.65966909
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65882852
133SMAD4_21799915_ChIP-Seq_A2780_Human0.65658671
134* TBX20_22328084_ChIP-Seq_HEART_Mouse0.65376911
135* TBX20_22080862_ChIP-Seq_HEART_Mouse0.65376911
136EZH2_27294783_Chip-Seq_ESCs_Mouse0.65036245
137DROSHA_22980978_ChIP-Seq_HELA_Human0.64529736
138P300_19829295_ChIP-Seq_ESCs_Human0.63782453
139SOX2_27498859_Chip-Seq_STOMACH_Mouse0.63706644
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.62467668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.61236875
2MP0005360_urolithiasis5.99076065
3MP0005085_abnormal_gallbladder_physiolo4.65760770
4MP0005365_abnormal_bile_salt4.55292391
5MP0008438_abnormal_cutaneous_collagen4.37649685
6MP0005058_abnormal_lysosome_morphology3.81743496
7MP0008875_abnormal_xenobiotic_pharmacok3.75877882
8MP0003252_abnormal_bile_duct3.54059730
9MP0005503_abnormal_tendon_morphology3.21311635
10MP0003806_abnormal_nucleotide_metabolis2.98516620
11MP0003195_calcinosis2.82034357
12MP0003122_maternal_imprinting2.80681786
13MP0003705_abnormal_hypodermis_morpholog2.75648099
14MP0006054_spinal_hemorrhage2.72169333
15MP0005275_abnormal_skin_tensile2.71564792
16MP0010329_abnormal_lipoprotein_level2.69861192
17MP0005332_abnormal_amino_acid2.43500747
18MP0009384_cardiac_valve_regurgitation2.29828958
19MP0009840_abnormal_foam_cell2.25094040
20MP0005083_abnormal_biliary_tract2.01436861
21MP0003279_aneurysm1.97842728
22MP0003172_abnormal_lysosome_physiology1.88616636
23MP0001666_abnormal_nutrient_absorption1.73080527
24MP0004272_abnormal_basement_membrane1.64761528
25MP0001915_intracranial_hemorrhage1.61502200
26MP0000343_altered_response_to1.61493581
27MP0004019_abnormal_vitamin_homeostasis1.59398237
28MP0002118_abnormal_lipid_homeostasis1.54040996
29MP0003868_abnormal_feces_composition1.47384676
30MP0010368_abnormal_lymphatic_system1.46803889
31MP0001958_emphysema1.45096069
32MP0000609_abnormal_liver_physiology1.36091177
33MP0002138_abnormal_hepatobiliary_system1.33861479
34MP0009780_abnormal_chondrocyte_physiolo1.31135189
35MP0009053_abnormal_anal_canal1.30619701
36MP0002295_abnormal_pulmonary_circulatio1.29431022
37MP0002998_abnormal_bone_remodeling1.29134784
38MP0005319_abnormal_enzyme/_coenzyme1.26404761
39MP0005167_abnormal_blood-brain_barrier1.24914592
40MP0002108_abnormal_muscle_morphology1.18344800
41MP0003011_delayed_dark_adaptation1.18167999
42MP0000566_synostosis1.13236595
43MP0005584_abnormal_enzyme/coenzyme_acti1.12395033
44MP0000013_abnormal_adipose_tissue1.11693219
45MP0002092_abnormal_eye_morphology1.10649295
46MP0006082_CNS_inflammation1.09050439
47MP0009697_abnormal_copulation1.08705377
48MP0003941_abnormal_skin_development1.06671051
49MP0005508_abnormal_skeleton_morphology1.05660890
50MP0002060_abnormal_skin_morphology1.05089958
51MP0002837_dystrophic_cardiac_calcinosis1.04643938
52MP0002089_abnormal_postnatal_growth/wei1.03665697
53MP0003191_abnormal_cellular_cholesterol1.02424361
54MP0003075_altered_response_to1.01883409
55MP0001542_abnormal_bone_strength0.98692660
56MP0000920_abnormal_myelination0.98413394
57MP0002896_abnormal_bone_mineralization0.97312328
58MP0002168_other_aberrant_phenotype0.96232699
59MP0005193_abnormal_anterior_eye0.94985089
60MP0003300_gastrointestinal_ulcer0.94954812
61MP0009643_abnormal_urine_homeostasis0.94515795
62MP0003634_abnormal_glial_cell0.93125890
63MP0002697_abnormal_eye_size0.92497229
64MP0002938_white_spotting0.88835708
65MP0004858_abnormal_nervous_system0.88155284
66MP0002254_reproductive_system_inflammat0.88150167
67MP0003690_abnormal_glial_cell0.86776655
68MP0005084_abnormal_gallbladder_morpholo0.86640033
69MP0005595_abnormal_vascular_smooth0.86111737
70MP0009250_abnormal_appendicular_skeleto0.85644014
71MP0003632_abnormal_nervous_system0.84454464
72MP0005623_abnormal_meninges_morphology0.81991877
73MP0002233_abnormal_nose_morphology0.81580272
74MP0005220_abnormal_exocrine_pancreas0.81551226
75MP0003123_paternal_imprinting0.80460661
76MP0003942_abnormal_urinary_system0.79157312
77MP0002282_abnormal_trachea_morphology0.79084642
78MP0001661_extended_life_span0.79074195
79MP0001764_abnormal_homeostasis0.79036422
80MP0001849_ear_inflammation0.78297751
81MP0000639_abnormal_adrenal_gland0.78091765
82MP0001243_abnormal_dermal_layer0.77390053
83MP0005647_abnormal_sex_gland0.77111859
84MP0005023_abnormal_wound_healing0.75257329
85MP0000604_amyloidosis0.74728365
86MP0000163_abnormal_cartilage_morphology0.74427758
87MP0002113_abnormal_skeleton_development0.74348578
88MP0000598_abnormal_liver_morphology0.72073912
89MP0010030_abnormal_orbit_morphology0.71972478
90MP0002115_abnormal_skeleton_extremities0.71570486
91MP0003186_abnormal_redox_activity0.71248555
92MP0003329_amyloid_beta_deposits0.71202248
93MP0005257_abnormal_intraocular_pressure0.71007547
94MP0002249_abnormal_larynx_morphology0.70966176
95MP0000534_abnormal_ureter_morphology0.69142702
96MP0005451_abnormal_body_composition0.68976573
97MP0002909_abnormal_adrenal_gland0.68461326
98MP0001324_abnormal_eye_pigmentation0.67248108
99MP0005248_abnormal_Harderian_gland0.67142808
100MP0002928_abnormal_bile_duct0.66364793
101MP0004130_abnormal_muscle_cell0.66241648
102MP0000371_diluted_coat_color0.65220526
103MP0001614_abnormal_blood_vessel0.64418943
104MP0005670_abnormal_white_adipose0.64308470
105MP0005164_abnormal_response_to0.64172241
106MP0004883_abnormal_blood_vessel0.63690997
107MP0001299_abnormal_eye_distance/0.62874862
108MP0001756_abnormal_urination0.62769527
109MP0002933_joint_inflammation0.62713587
110MP0001533_abnormal_skeleton_physiology0.62660110
111MP0005171_absent_coat_pigmentation0.62216285
112MP0009764_decreased_sensitivity_to0.62204431
113MP0002876_abnormal_thyroid_physiology0.62126678
114MP0000767_abnormal_smooth_muscle0.61264533
115MP0000428_abnormal_craniofacial_morphol0.60964332
116MP0001293_anophthalmia0.60835263
117MP0001177_atelectasis0.60665678
118MP0005390_skeleton_phenotype0.60637218
119MP0005408_hypopigmentation0.59540184
120MP0002971_abnormal_brown_adipose0.58572245
121MP0002090_abnormal_vision0.57897058
122MP0003566_abnormal_cell_adhesion0.57504174
123MP0005395_other_phenotype0.56550023
124MP0003115_abnormal_respiratory_system0.56500088
125MP0005376_homeostasis/metabolism_phenot0.56322118
126MP0003385_abnormal_body_wall0.55799891
127MP0005197_abnormal_uvea_morphology0.54647559
128MP0000751_myopathy0.54471932
129MP0000230_abnormal_systemic_arterial0.52453919
130MP0005636_abnormal_mineral_homeostasis0.52331016
131MP0003091_abnormal_cell_migration0.52172068
132MP0002078_abnormal_glucose_homeostasis0.51516289
133MP0003283_abnormal_digestive_organ0.51512112
134MP0009642_abnormal_blood_homeostasis0.50140154
135MP0000003_abnormal_adipose_tissue0.50093227
136MP0002128_abnormal_blood_circulation0.49205785
137MP0005334_abnormal_fat_pad0.49137124

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.21750782
2Intrahepatic cholestasis (HP:0001406)5.62933304
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.42791707
4Xanthomatosis (HP:0000991)5.31988114
5Protrusio acetabuli (HP:0003179)4.85174693
6Abnormality of liposaccharide metabolism (HP:0010968)4.76703453
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.76703453
8Abnormality of glycolipid metabolism (HP:0010969)4.76703453
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.74996852
10Prolonged partial thromboplastin time (HP:0003645)4.70898744
11Hyperlipoproteinemia (HP:0010980)4.45028167
12Hypobetalipoproteinemia (HP:0003563)4.40051213
13Complement deficiency (HP:0004431)4.25561524
14Premature rupture of membranes (HP:0001788)4.02604276
15Vacuolated lymphocytes (HP:0001922)3.91976568
16Hypoalphalipoproteinemia (HP:0003233)3.86648795
17Hypolipoproteinemia (HP:0010981)3.83850337
18Abnormality of the common coagulation pathway (HP:0010990)3.57587277
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.55336465
20Ketosis (HP:0001946)3.47127025
21Hyperglycinemia (HP:0002154)3.41279442
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.38637184
23Hyperammonemia (HP:0001987)3.37170432
24Epidermoid cyst (HP:0200040)3.25253855
25Abnormality of the intrinsic pathway (HP:0010989)3.24548490
26Mitral stenosis (HP:0001718)3.22367239
27Joint hemorrhage (HP:0005261)3.20241131
28Hyperglycinuria (HP:0003108)3.19637218
29Abnormality of serine family amino acid metabolism (HP:0010894)3.18465256
30Abnormality of glycine metabolism (HP:0010895)3.18465256
31Dysostosis multiplex (HP:0000943)3.11475029
32Hypoglycemic coma (HP:0001325)3.08882421
33Urinary glycosaminoglycan excretion (HP:0003541)3.07336891
34Mucopolysacchariduria (HP:0008155)3.07336891
35Abnormality of complement system (HP:0005339)3.06029429
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.04946002
37Neurofibrillary tangles (HP:0002185)3.04479713
38Nuclear cataract (HP:0100018)3.03214013
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.99228790
40Abnormality of methionine metabolism (HP:0010901)2.95438851
41Abnormality of polysaccharide metabolism (HP:0011012)2.92745811
42Abnormality of glycosaminoglycan metabolism (HP:0004371)2.92745811
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.92745811
44Fat malabsorption (HP:0002630)2.92396523
45Skin nodule (HP:0200036)2.89341485
46Broad metatarsal (HP:0001783)2.87841014
47Ketoacidosis (HP:0001993)2.87669950
48Cardiovascular calcification (HP:0011915)2.84574216
49Peritonitis (HP:0002586)2.71741789
50Delayed CNS myelination (HP:0002188)2.62785279
51Myocardial infarction (HP:0001658)2.60234095
52Hepatocellular carcinoma (HP:0001402)2.58720562
53Metaphyseal irregularity (HP:0003025)2.55631574
54Biconcave vertebral bodies (HP:0004586)2.52882920
55Hypercholesterolemia (HP:0003124)2.51257609
56Vascular tortuosity (HP:0004948)2.49019154
57Vascular calcification (HP:0004934)2.47859619
58Conjugated hyperbilirubinemia (HP:0002908)2.40687378
59Abnormality of fatty-acid metabolism (HP:0004359)2.39420302
60Aortic dissection (HP:0002647)2.39218585
61Back pain (HP:0003418)2.37625417
62Loss of speech (HP:0002371)2.35230873
63Ankle contracture (HP:0006466)2.34607850
64Increased cerebral lipofuscin (HP:0011813)2.34555483
65Arterial tortuosity (HP:0005116)2.34390658
66Neonatal short-limb short stature (HP:0008921)2.33243334
67Infantile muscular hypotonia (HP:0008947)2.32283308
68Nephritis (HP:0000123)2.30638699
69Spontaneous abortion (HP:0005268)2.30315491
70Ovoid vertebral bodies (HP:0003300)2.29373520
71Ectopia lentis (HP:0001083)2.27411947
72Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.24993398
73Renal duplication (HP:0000075)2.24042405
74Disinhibition (HP:0000734)2.18922080
75Hydroxyprolinuria (HP:0003080)2.18888028
76Abnormality of proline metabolism (HP:0010907)2.18888028
77Enlarged kidneys (HP:0000105)2.18578864
78Abnormality of dentin (HP:0010299)2.14905535
79Coronal craniosynostosis (HP:0004440)2.13933262
80Abnormality of the lumbar spine (HP:0100712)2.13216458
81Abnormality of serum amino acid levels (HP:0003112)2.12668548
82Shallow orbits (HP:0000586)2.12469810
83Recurrent gram-negative bacterial infections (HP:0005420)2.12443360
84Hyperbilirubinemia (HP:0002904)2.12300420
85Cerebral inclusion bodies (HP:0100314)2.11785341
86Amyloidosis (HP:0011034)2.09661722
87Soft skin (HP:0000977)2.09200560
88Abnormal delivery (HP:0001787)2.08690849
89Flared iliac wings (HP:0002869)2.08546593
90Turricephaly (HP:0000262)2.07091586
91Axonal loss (HP:0003447)2.06964414
92Steatorrhea (HP:0002570)2.06501423
93Arthropathy (HP:0003040)2.05388725
94Hypoglycemic seizures (HP:0002173)2.04133339
95Blue sclerae (HP:0000592)2.03735889
96Cupped ribs (HP:0000887)2.03620927
97Aortic aneurysm (HP:0004942)2.03460396
98Hepatoblastoma (HP:0002884)2.03117831
99Follicular hyperkeratosis (HP:0007502)2.02565958
100Retinal atrophy (HP:0001105)2.02504909
101Pathologic fracture (HP:0002756)2.01803045
102Abnormality of purine metabolism (HP:0004352)2.01377860
103Mitral valve prolapse (HP:0001634)2.01220413
104Abnormal cartilage morphology (HP:0002763)2.00612363
105Gout (HP:0001997)1.98151023
106Sensorimotor neuropathy (HP:0007141)1.97708007
107Hypophosphatemic rickets (HP:0004912)1.97690500
108Thin bony cortex (HP:0002753)1.95603058
109Vertebral compression fractures (HP:0002953)1.95070872
110Abnormality of nucleobase metabolism (HP:0010932)1.94999190
111Abnormality of carpal bone ossification (HP:0006257)1.91955220
112Cervical subluxation (HP:0003308)1.90529495
113Hyperextensible skin (HP:0000974)1.88227343
114Beaking of vertebral bodies (HP:0004568)1.86991702
115Neonatal onset (HP:0003623)1.85577674
116Vitreoretinal degeneration (HP:0000655)1.85084687
117Purpura (HP:0000979)1.83986390
118Protuberant abdomen (HP:0001538)1.83760457
119Metabolic acidosis (HP:0001942)1.82978519
120Abnormality of pyrimidine metabolism (HP:0004353)1.82241849
121Spastic diplegia (HP:0001264)1.82081622
122Cortical dysplasia (HP:0002539)1.81674664
123Abnormality of the acetabulum (HP:0003170)1.80793546
124Upper motor neuron abnormality (HP:0002127)1.80658215
125Osteoarthritis (HP:0002758)1.79087034
126Wide anterior fontanel (HP:0000260)1.77246793
127Abnormal gallbladder morphology (HP:0012437)1.76125276
128Rickets (HP:0002748)1.74513060
129Spondylolisthesis (HP:0003302)1.74329925
130Lethargy (HP:0001254)1.74288514
131Cerebral aneurysm (HP:0004944)1.73252330
132Systemic lupus erythematosus (HP:0002725)1.72266093
133Epiphyseal dysplasia (HP:0002656)1.71784497
134Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71776466
135Dicarboxylic aciduria (HP:0003215)1.71776466
136Glomerulonephritis (HP:0000099)1.71627422
137Long toe (HP:0010511)1.70695339
138Pulmonary artery stenosis (HP:0004415)1.70561940
139Dilatation of the ascending aorta (HP:0005111)1.70371940
140Aplasia involving bones of the upper limbs (HP:0009823)1.69773280
141Aplasia of the phalanges of the hand (HP:0009802)1.69773280
142Aplasia involving bones of the extremities (HP:0009825)1.69773280
143Delayed epiphyseal ossification (HP:0002663)1.69384860
144Joint stiffness (HP:0001387)1.69196310
145Wormian bones (HP:0002645)1.68983815
146Bladder diverticulum (HP:0000015)1.68599784
147Overgrowth (HP:0001548)1.68301810
148Abnormality of the Achilles tendon (HP:0005109)1.67767556
149Esophageal varix (HP:0002040)1.67654791
150Atrophic scars (HP:0001075)1.67176678
151Mitral regurgitation (HP:0001653)1.64596292
152Abnormal ossification of hand bones (HP:0005921)1.63876353
153Asymmetric septal hypertrophy (HP:0001670)1.63774728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.35851347
2BCKDK3.69027449
3DDR23.20532548
4LATS12.78086919
5TRIB32.72669074
6ERN12.67135465
7LIMK12.52535090
8PDGFRA2.49940956
9FRK2.42402537
10FGFR42.41451057
11ERBB42.25837794
12INSRR2.22576055
13TYRO32.10148348
14PAK32.02698133
15TESK11.94961508
16LATS21.94552809
17STK38L1.91205948
18TTN1.87769810
19IRAK31.81698301
20FGFR21.81547486
21RIPK11.77849013
22EPHB21.71695480
23PIK3CG1.69671179
24EPHA31.57438415
25PAK41.56588120
26ICK1.55750158
27PKN21.54124487
28FER1.50872055
29CDC42BPA1.49905863
30STK241.45252486
31GRK71.44324383
32MST1R1.43937908
33PTK61.42817028
34PTK21.42642862
35MET1.37965396
36MAP2K41.35204589
37NEK91.27093202
38PIK3CA1.22549551
39MYLK1.22433381
40FGR1.20100232
41NME21.18079677
42CAMKK21.14224892
43NTRK11.10679688
44PAK21.09640658
45ROCK11.07378156
46PTK2B1.03887179
47CAMK1D1.00852190
48FGFR10.96471827
49ACVR1B0.96388494
50BMX0.95387734
51ABL20.93715620
52ARAF0.91326280
53DMPK0.87220846
54BCR0.87019809
55CAMK1G0.86348700
56MOS0.85031981
57PIM20.84674781
58CAMK2G0.84605958
59MAP3K30.84446390
60EPHA40.83858918
61TGFBR20.83601400
62MATK0.83310231
63MAP2K10.82934768
64RPS6KA20.82164683
65WNK40.79993340
66TRPM70.77203781
67PDK30.77049454
68PDK40.77049454
69CDK150.76944943
70STK30.76670856
71LMTK20.76227778
72PHKG20.75702180
73PHKG10.75702180
74PRKCH0.74914467
75RET0.74825164
76CDK180.73437720
77MAPK110.73382461
78MAP3K70.71014970
79DAPK20.70748809
80ERBB30.69403777
81CDK11A0.68842610
82PAK60.68400723
83ERBB20.68114162
84CDK140.68105798
85FLT30.67403290
86PRKAA20.66618102
87MAPK120.65805740
88PLK20.64675409
89JAK10.64568452
90MAPK70.63673200
91ADRBK10.63263849
92MAPK150.60869772
93MAPKAPK50.60443340
94IGF1R0.59122536
95PRKCZ0.58823290
96PRKCE0.58300353
97PDK20.58283143
98PRKG20.57942897
99GSK3A0.57354836
100CSNK1A1L0.57059076
101CAMK2D0.55342513
102FGFR30.54135773
103CSNK1G30.53635592
104PDGFRB0.53408687
105MTOR0.52423840
106CAMK2A0.51440878
107SGK30.51096486
108TAOK30.50459465
109PRKD30.50427468
110PRKACG0.49452570
111ROCK20.49091749
112DYRK30.48947990
113RPS6KC10.47374603
114RPS6KL10.47374603
115MAP3K50.47128538
116NUAK10.46671443
117DYRK1B0.46352860
118CSNK1G10.46237333
119MAP3K60.46179968
120SGK4940.45982901
121SGK2230.45982901
122EPHB10.45909962
123INSR0.45799541
124* SRC0.44906874
125NTRK20.44541150
126KSR20.43924593
127SGK20.43579769
128PRKD10.43456194
129TNIK0.41247220
130NEK10.40962468
131PRKACB0.40794657
132PRKAA10.40519350
133PINK10.40375387
134WNK10.40273843
135MAP3K140.39419568
136DAPK30.39031553
137MAPK40.38155756
138* PRKCG0.37988591
139MAP3K90.37744491
140CAMKK10.36917793
141YES10.36259131
142CDK60.33742840
143STK380.33686696
144CSNK1G20.33432662

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.13290437
2Nitrogen metabolism_Homo sapiens_hsa009103.87659945
3Other glycan degradation_Homo sapiens_hsa005113.21862127
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10944776
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94069506
6Lysosome_Homo sapiens_hsa041422.79427437
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.74279192
8Arginine biosynthesis_Homo sapiens_hsa002202.73935496
9Complement and coagulation cascades_Homo sapiens_hsa046102.66343398
10Fatty acid degradation_Homo sapiens_hsa000712.52642370
11Tryptophan metabolism_Homo sapiens_hsa003802.52340810
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43560266
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37716774
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34087750
15Butanoate metabolism_Homo sapiens_hsa006502.19642513
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.16888087
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08957621
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00967056
19Fatty acid metabolism_Homo sapiens_hsa012121.99341602
20Propanoate metabolism_Homo sapiens_hsa006401.98764674
21PPAR signaling pathway_Homo sapiens_hsa033201.94273744
22Peroxisome_Homo sapiens_hsa041461.92366414
23Chemical carcinogenesis_Homo sapiens_hsa052041.88140725
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.83857436
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83603412
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66063728
27Bile secretion_Homo sapiens_hsa049761.65781938
28Histidine metabolism_Homo sapiens_hsa003401.62897897
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61330170
30Sulfur metabolism_Homo sapiens_hsa009201.58845487
31Retinol metabolism_Homo sapiens_hsa008301.53424736
32Phenylalanine metabolism_Homo sapiens_hsa003601.48016300
33beta-Alanine metabolism_Homo sapiens_hsa004101.47900337
34Tyrosine metabolism_Homo sapiens_hsa003501.47408352
35Caffeine metabolism_Homo sapiens_hsa002321.45799583
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40988369
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39147938
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39084140
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37642366
40Starch and sucrose metabolism_Homo sapiens_hsa005001.37197646
41Pyruvate metabolism_Homo sapiens_hsa006201.36121055
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32324779
43Pertussis_Homo sapiens_hsa051331.30533732
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.27696305
45Steroid biosynthesis_Homo sapiens_hsa001001.21579961
46Fatty acid elongation_Homo sapiens_hsa000621.20380786
47Staphylococcus aureus infection_Homo sapiens_hsa051501.20085864
48Vibrio cholerae infection_Homo sapiens_hsa051101.17531299
49Selenocompound metabolism_Homo sapiens_hsa004501.15087067
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13215099
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01726024
52Carbon metabolism_Homo sapiens_hsa012001.01650143
53Arginine and proline metabolism_Homo sapiens_hsa003301.01349995
54Biosynthesis of amino acids_Homo sapiens_hsa012300.98127420
55Phagosome_Homo sapiens_hsa041450.97101100
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.96647181
57Sphingolipid metabolism_Homo sapiens_hsa006000.90574617
58ABC transporters_Homo sapiens_hsa020100.89948179
59Fatty acid biosynthesis_Homo sapiens_hsa000610.85490886
60Fat digestion and absorption_Homo sapiens_hsa049750.83869206
61Vitamin digestion and absorption_Homo sapiens_hsa049770.79344105
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.76312849
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75157940
64Mineral absorption_Homo sapiens_hsa049780.74783814
65Lysine degradation_Homo sapiens_hsa003100.74186274
66ECM-receptor interaction_Homo sapiens_hsa045120.72148967
67Folate biosynthesis_Homo sapiens_hsa007900.70681533
68Basal cell carcinoma_Homo sapiens_hsa052170.70060312
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70011844
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68719853
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67716107
72Adherens junction_Homo sapiens_hsa045200.67186787
73Rheumatoid arthritis_Homo sapiens_hsa053230.66850463
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65905180
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.65195122
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64005829
77Glutathione metabolism_Homo sapiens_hsa004800.63828159
78Collecting duct acid secretion_Homo sapiens_hsa049660.62358747
79Salmonella infection_Homo sapiens_hsa051320.58968603
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55348939
81Glycerolipid metabolism_Homo sapiens_hsa005610.55243870
82Sulfur relay system_Homo sapiens_hsa041220.54271312
83Vitamin B6 metabolism_Homo sapiens_hsa007500.53090511
84Prion diseases_Homo sapiens_hsa050200.50956062
85Hippo signaling pathway_Homo sapiens_hsa043900.48511646
86Protein digestion and absorption_Homo sapiens_hsa049740.46239175
87N-Glycan biosynthesis_Homo sapiens_hsa005100.45438660
88Hedgehog signaling pathway_Homo sapiens_hsa043400.44050003
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43798428
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39433777
91Notch signaling pathway_Homo sapiens_hsa043300.37163101
92* Malaria_Homo sapiens_hsa051440.37134729
93Metabolic pathways_Homo sapiens_hsa011000.35302165
94Insulin resistance_Homo sapiens_hsa049310.30573117
95Thyroid hormone synthesis_Homo sapiens_hsa049180.30357813
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.28590343
97Ovarian steroidogenesis_Homo sapiens_hsa049130.28374699
98Glucagon signaling pathway_Homo sapiens_hsa049220.27782479
99Focal adhesion_Homo sapiens_hsa045100.26994495
100Amoebiasis_Homo sapiens_hsa051460.25952099
101Pentose phosphate pathway_Homo sapiens_hsa000300.25131772
102Galactose metabolism_Homo sapiens_hsa000520.21919174
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19387731
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18230751
105One carbon pool by folate_Homo sapiens_hsa006700.17557414
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15224150
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15046291
108Dilated cardiomyopathy_Homo sapiens_hsa054140.14471872
109Bladder cancer_Homo sapiens_hsa052190.13277397
110AMPK signaling pathway_Homo sapiens_hsa041520.11322231
111Fructose and mannose metabolism_Homo sapiens_hsa000510.09612469
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09582851
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09531178
114TGF-beta signaling pathway_Homo sapiens_hsa043500.08717703
115Cocaine addiction_Homo sapiens_hsa050300.07587901
116* Proteoglycans in cancer_Homo sapiens_hsa052050.06987863
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04978331
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.01507163
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.00824503
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.00076112
121Linoleic acid metabolism_Homo sapiens_hsa00591-0.0159430
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0082499
123Renin-angiotensin system_Homo sapiens_hsa04614-0.0032544
124Insulin signaling pathway_Homo sapiens_hsa04910-0.0010553

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