SDC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.66675074
2layer formation in cerebral cortex (GO:0021819)4.66041218
3locomotory exploration behavior (GO:0035641)4.55996679
4pyrimidine nucleobase catabolic process (GO:0006208)4.28419197
5presynaptic membrane assembly (GO:0097105)4.25548192
6dermatan sulfate biosynthetic process (GO:0030208)4.24913887
7regulation of synapse structural plasticity (GO:0051823)4.23594420
8nucleobase catabolic process (GO:0046113)4.18147395
9dermatan sulfate metabolic process (GO:0030205)4.01769825
10vocalization behavior (GO:0071625)3.98749341
11presynaptic membrane organization (GO:0097090)3.92522186
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.92498310
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.86780409
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.81550135
15clathrin coat assembly (GO:0048268)3.81114282
16exploration behavior (GO:0035640)3.71084462
17proline transport (GO:0015824)3.67689254
18regulation of axon extension involved in axon guidance (GO:0048841)3.59853890
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.58248818
20apoptotic cell clearance (GO:0043277)3.57730499
21dendrite morphogenesis (GO:0048813)3.54649713
22regulation of glutamate receptor signaling pathway (GO:1900449)3.52880829
23positive regulation of axon extension (GO:0045773)3.43629228
24sodium ion export (GO:0071436)3.42253614
25regulation of synaptic vesicle exocytosis (GO:2000300)3.40294361
26synaptic vesicle exocytosis (GO:0016079)3.37736329
27glutamate secretion (GO:0014047)3.32571987
28protein localization to synapse (GO:0035418)3.32237141
29dendritic spine morphogenesis (GO:0060997)3.31708537
30neuron cell-cell adhesion (GO:0007158)3.26466848
31regulation of axon guidance (GO:1902667)3.20236756
32neurotransmitter-gated ion channel clustering (GO:0072578)3.15584905
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.15492570
34gamma-aminobutyric acid transport (GO:0015812)3.15378531
35chondroitin sulfate catabolic process (GO:0030207)3.14445724
36auditory behavior (GO:0031223)3.14263314
37activation of protein kinase A activity (GO:0034199)3.12779400
38negative regulation of catenin import into nucleus (GO:0035414)3.10070457
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09293580
40negative regulation of cell killing (GO:0031342)3.09293580
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08235106
42cerebellar Purkinje cell layer development (GO:0021680)3.05987045
43response to auditory stimulus (GO:0010996)3.05428143
44synaptic transmission, glutamatergic (GO:0035249)3.03455396
45negative regulation of axon extension involved in axon guidance (GO:0048843)3.00146360
46astrocyte differentiation (GO:0048708)3.00041203
47regulation of ARF protein signal transduction (GO:0032012)2.99498598
48alanine transport (GO:0032328)2.98661045
49cytoskeletal anchoring at plasma membrane (GO:0007016)2.98276560
50axon extension (GO:0048675)2.97951048
51membrane assembly (GO:0071709)2.96911864
52negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95554756
53potassium ion homeostasis (GO:0055075)2.91465418
54camera-type eye morphogenesis (GO:0048593)2.90259097
55transmission of nerve impulse (GO:0019226)2.89365684
56cellular potassium ion homeostasis (GO:0030007)2.88773677
57regulation of synaptic vesicle transport (GO:1902803)2.87476747
58neuromuscular process controlling balance (GO:0050885)2.87271838
59positive regulation of synapse assembly (GO:0051965)2.84626359
60postsynaptic membrane organization (GO:0001941)2.82688599
61neuron projection regeneration (GO:0031102)2.81860575
62neurotransmitter secretion (GO:0007269)2.80624935
63regulation of long-term neuronal synaptic plasticity (GO:0048169)2.80585347
64neuron recognition (GO:0008038)2.79463104
65positive regulation of synapse maturation (GO:0090129)2.79416996
66ionotropic glutamate receptor signaling pathway (GO:0035235)2.76738242
67cell migration in hindbrain (GO:0021535)2.76281306
68semaphorin-plexin signaling pathway (GO:0071526)2.75700042
69axonal fasciculation (GO:0007413)2.75178817
70regulation of neuronal synaptic plasticity (GO:0048168)2.73583709
71L-amino acid import (GO:0043092)2.71644872
72potassium ion import (GO:0010107)2.69801788
73planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69678852
74cell communication by electrical coupling (GO:0010644)2.69635417
75axon ensheathment in central nervous system (GO:0032291)2.69476377
76central nervous system myelination (GO:0022010)2.69476377
77myelination in peripheral nervous system (GO:0022011)2.68726793
78peripheral nervous system axon ensheathment (GO:0032292)2.68726793
79neuron projection extension (GO:1990138)2.68498838
80cell adhesion mediated by integrin (GO:0033627)2.68309292
81astrocyte development (GO:0014002)2.65226808
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64864606
83axon extension involved in axon guidance (GO:0048846)2.62827440
84neuron projection extension involved in neuron projection guidance (GO:1902284)2.62827440
85positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.61638650
86neuronal ion channel clustering (GO:0045161)2.58912638
87response to pheromone (GO:0019236)2.58586659
88regulation of cholesterol storage (GO:0010885)2.58070442
89positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.57874614
90central nervous system projection neuron axonogenesis (GO:0021952)2.57141670
91regulation of axon extension (GO:0030516)2.57101348
92negative chemotaxis (GO:0050919)2.57073766
93neuron remodeling (GO:0016322)2.57043038
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.56959218
95nerve growth factor signaling pathway (GO:0038180)2.52609606
96positive regulation by organism of defense response of other organism involved in symbiotic interact2.51473598
97modulation by symbiont of host immune response (GO:0052553)2.51473598
98positive regulation by symbiont of host defense response (GO:0052509)2.51473598
99modulation by symbiont of host defense response (GO:0052031)2.51473598
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51473598
101modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.51473598
102protein heterotrimerization (GO:0070208)2.50316465
103synaptic vesicle endocytosis (GO:0048488)2.50216635
104regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.50014755
105negative regulation of axon guidance (GO:1902668)2.49775794
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.47784382
107spinal cord development (GO:0021510)2.47171324
108cellular sodium ion homeostasis (GO:0006883)2.46964398
109synapse assembly (GO:0007416)2.46270465
110organelle transport along microtubule (GO:0072384)2.45183646
111regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.45105448
112axon regeneration (GO:0031103)2.45032767
113regulation of synapse maturation (GO:0090128)2.43876296
114axon cargo transport (GO:0008088)2.43729282
115establishment of nucleus localization (GO:0040023)2.43032195
116negative regulation of microtubule polymerization (GO:0031115)2.42647565
117tooth mineralization (GO:0034505)2.41696548
118cellular response to nerve growth factor stimulus (GO:1990090)2.41057951
119response to nerve growth factor (GO:1990089)2.41057951
120positive regulation of fibroblast migration (GO:0010763)2.40233552
121regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.39787964
122establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.39344028
123mitochondrion transport along microtubule (GO:0047497)2.39344028
124positive regulation of dendritic spine development (GO:0060999)2.38064417
125vesicle transport along microtubule (GO:0047496)2.37665349
126cell proliferation in forebrain (GO:0021846)2.36696944
127regulation of axonogenesis (GO:0050770)2.35624823
128outer ear morphogenesis (GO:0042473)2.35499731
129negative regulation of axon extension (GO:0030517)2.35404967
130positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.35199981
131positive regulation of axonogenesis (GO:0050772)2.35197121
132positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.34638390
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.34460415
134regulation of ARF GTPase activity (GO:0032312)2.32990365
135mechanosensory behavior (GO:0007638)2.32740415
136dendritic spine organization (GO:0097061)2.32415885
137regulation of respiratory system process (GO:0044065)2.32331331
138heparan sulfate proteoglycan metabolic process (GO:0030201)2.32316287
139amino acid import (GO:0043090)2.31345423
140glutamate receptor signaling pathway (GO:0007215)2.30635864
141dopamine receptor signaling pathway (GO:0007212)2.28970419
142membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.27629230
143glycine transport (GO:0015816)2.27414513
144positive regulation of filopodium assembly (GO:0051491)2.27175738
145cerebellar granule cell differentiation (GO:0021707)2.24715215
146positive regulation of nitric-oxide synthase activity (GO:0051000)2.23216254
147mating behavior (GO:0007617)2.22630368
148regulation of extent of cell growth (GO:0061387)2.21748436
149regulation of dendritic spine morphogenesis (GO:0061001)2.21663013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.79347372
2STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31744876
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29802925
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27261887
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.23964531
6DROSHA_22980978_ChIP-Seq_HELA_Human2.23898870
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17828683
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15840889
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15840889
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14387049
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09841781
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06480069
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03457392
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00035282
15IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96645339
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96049215
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94488650
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94040616
19GBX2_23144817_ChIP-Seq_PC3_Human1.80103137
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.78903430
21REST_21632747_ChIP-Seq_MESCs_Mouse1.77632474
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75314874
23* KDM2B_26808549_Chip-Seq_K562_Human1.74851079
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74035052
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.73509832
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.72426358
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.71818047
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.70946100
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.69418690
30AR_21572438_ChIP-Seq_LNCaP_Human1.65369780
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65311454
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64110833
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63536947
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61570485
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.58492048
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55685301
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52229164
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.51888335
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47510901
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47104046
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45505492
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.45022743
43* LXR_22292898_ChIP-Seq_THP-1_Human1.44871288
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39319366
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38521229
46* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35598216
47KDM2B_26808549_Chip-Seq_DND41_Human1.34152332
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33986718
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26561177
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25818836
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25377857
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22959246
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22269838
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.20929637
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.20887950
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19147637
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18167879
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18071158
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17059847
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16020743
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15622679
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.15107037
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14806300
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12382735
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.11529449
66TP53_23651856_ChIP-Seq_MEFs_Mouse1.11518442
67* IRF8_27001747_Chip-Seq_BMDM_Mouse1.11518301
68* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06331794
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05896213
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05411443
71* CTCF_27219007_Chip-Seq_Bcells_Human1.04941959
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03968355
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02922853
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02810563
75VDR_24787735_ChIP-Seq_THP-1_Human1.02434761
76AHR_22903824_ChIP-Seq_MCF-7_Human1.01928622
77* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01304508
78* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99664759
79ESR2_21235772_ChIP-Seq_MCF-7_Human0.99260039
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98815472
81SPI1_23127762_ChIP-Seq_K562_Human0.98464226
82* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98256112
83AR_19668381_ChIP-Seq_PC3_Human0.97270929
84* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97080840
85TP53_16413492_ChIP-PET_HCT116_Human0.96253816
86ISL1_27105846_Chip-Seq_CPCs_Mouse0.95936315
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95390007
88RING1B_27294783_Chip-Seq_NPCs_Mouse0.95109001
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.94536270
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92834746
91* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90652207
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89984846
93RNF2_27304074_Chip-Seq_NSC_Mouse0.89708076
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87553168
95GATA1_26923725_Chip-Seq_HPCs_Mouse0.87493107
96* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86980496
97ZNF274_21170338_ChIP-Seq_K562_Hela0.86882402
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85685634
99TP63_17297297_ChIP-ChIP_HaCaT_Human0.85636674
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.85249496
101BP1_19119308_ChIP-ChIP_Hs578T_Human0.84919933
102SMAD3_21741376_ChIP-Seq_ESCs_Human0.84810439
103* SMAD4_21741376_ChIP-Seq_HESCs_Human0.84535307
104NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83779444
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83708631
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83315664
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83247722
108* TET1_21490601_ChIP-Seq_MESCs_Mouse0.82635282
109* SMAD4_21799915_ChIP-Seq_A2780_Human0.82328900
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81211976
111TP53_18474530_ChIP-ChIP_U2OS_Human0.80745962
112BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80380179
113* ELK3_25401928_ChIP-Seq_HUVEC_Human0.80369849
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80339304
115GATA1_19941826_ChIP-Seq_K562_Human0.80018719
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79877252
117ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79869249
118RXR_22108803_ChIP-Seq_LS180_Human0.78851371
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.78718201
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78600008
121TCF7_22412390_ChIP-Seq_EML_Mouse0.77983701
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77918215
123NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.77821584
124SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76965033
125POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75536863
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.75495370
127RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75407123
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74900669
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.73028242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.50731724
2MP0004858_abnormal_nervous_system3.34182031
3MP0003329_amyloid_beta_deposits3.28311097
4MP0003635_abnormal_synaptic_transmissio3.17337901
5MP0003303_peritoneal_inflammation3.16059805
6MP0004270_analgesia3.03171719
7MP0000604_amyloidosis2.79377954
8MP0000569_abnormal_digit_pigmentation2.55810637
9MP0009780_abnormal_chondrocyte_physiolo2.54636769
10MP0005423_abnormal_somatic_nervous2.53523637
11MP0002063_abnormal_learning/memory/cond2.44719390
12MP0005171_absent_coat_pigmentation2.39836185
13MP0003172_abnormal_lysosome_physiology2.35136724
14MP0005503_abnormal_tendon_morphology2.31144016
15MP0002909_abnormal_adrenal_gland2.24053811
16MP0003880_abnormal_central_pattern2.21723971
17MP0002064_seizures2.16386250
18MP0004510_myositis2.15497663
19MP0001968_abnormal_touch/_nociception2.06906009
20MP0003705_abnormal_hypodermis_morpholog2.03337621
21MP0009745_abnormal_behavioral_response2.02082044
22MP0002734_abnormal_mechanical_nocicepti2.00075185
23MP0005058_abnormal_lysosome_morphology1.98994281
24MP0000778_abnormal_nervous_system1.98984186
25MP0003075_altered_response_to1.96162664
26MP0002733_abnormal_thermal_nociception1.85870733
27MP0002249_abnormal_larynx_morphology1.84794651
28MP0003690_abnormal_glial_cell1.84733171
29MP0004811_abnormal_neuron_physiology1.76831857
30MP0009046_muscle_twitch1.72548535
31MP0002572_abnormal_emotion/affect_behav1.71076562
32MP0000049_abnormal_middle_ear1.70699405
33MP0000534_abnormal_ureter_morphology1.68026373
34MP0005409_darkened_coat_color1.63995678
35MP0002736_abnormal_nociception_after1.63545072
36MP0003191_abnormal_cellular_cholesterol1.60055728
37MP0008438_abnormal_cutaneous_collagen1.58260957
38MP0003634_abnormal_glial_cell1.56843766
39MP0002735_abnormal_chemical_nociception1.56239109
40MP0003136_yellow_coat_color1.55026065
41MP0004885_abnormal_endolymph1.50768047
42MP0001970_abnormal_pain_threshold1.50660489
43MP0002184_abnormal_innervation1.48210683
44MP0009250_abnormal_appendicular_skeleto1.47310446
45MP0004130_abnormal_muscle_cell1.44480318
46MP0009384_cardiac_valve_regurgitation1.42479606
47MP0001440_abnormal_grooming_behavior1.39432619
48MP0000955_abnormal_spinal_cord1.37323922
49MP0009053_abnormal_anal_canal1.37153536
50MP0009379_abnormal_foot_pigmentation1.36760044
51MP0003633_abnormal_nervous_system1.35572284
52MP0001486_abnormal_startle_reflex1.33313548
53MP0003942_abnormal_urinary_system1.33116042
54MP0004134_abnormal_chest_morphology1.29744687
55MP0005646_abnormal_pituitary_gland1.27851408
56MP0004272_abnormal_basement_membrane1.27048243
57MP0008569_lethality_at_weaning1.24492405
58MP0001348_abnormal_lacrimal_gland1.22383316
59MP0005623_abnormal_meninges_morphology1.22119412
60MP0002067_abnormal_sensory_capabilities1.21016499
61MP0003300_gastrointestinal_ulcer1.19980521
62MP0001501_abnormal_sleep_pattern1.18937383
63MP0000751_myopathy1.18493254
64MP0005508_abnormal_skeleton_morphology1.16069341
65MP0002557_abnormal_social/conspecific_i1.15538442
66MP0003938_abnormal_ear_development1.14905929
67MP0000537_abnormal_urethra_morphology1.14493585
68MP0005275_abnormal_skin_tensile1.13971992
69MP0002090_abnormal_vision1.13180853
70MP0003632_abnormal_nervous_system1.11568234
71MP0003631_nervous_system_phenotype1.11496742
72MP0009840_abnormal_foam_cell1.11426085
73MP0003879_abnormal_hair_cell1.10534077
74MP0001533_abnormal_skeleton_physiology1.10420144
75MP0000678_abnormal_parathyroid_gland1.09841292
76MP0005167_abnormal_blood-brain_barrier1.08607090
77MP0001299_abnormal_eye_distance/1.06062300
78MP0002882_abnormal_neuron_morphology1.05576482
79MP0002116_abnormal_craniofacial_bone1.05465895
80MP0000026_abnormal_inner_ear1.05460168
81MP0005076_abnormal_cell_differentiation1.01858338
82MP0000428_abnormal_craniofacial_morphol1.01702083
83MP0005166_decreased_susceptibility_to1.01601457
84MP0003091_abnormal_cell_migration1.01381817
85MP0008961_abnormal_basal_metabolism1.01093830
86MP0002066_abnormal_motor_capabilities/c1.00556662
87MP0005386_behavior/neurological_phenoty0.96961062
88MP0004924_abnormal_behavior0.96961062
89MP0002822_catalepsy0.95899421
90MP0002272_abnormal_nervous_system0.95730319
91MP0010368_abnormal_lymphatic_system0.95458306
92MP0001963_abnormal_hearing_physiology0.94854045
93MP0001958_emphysema0.94847063
94MP0002998_abnormal_bone_remodeling0.94281156
95MP0003385_abnormal_body_wall0.94050322
96MP0000733_abnormal_muscle_development0.93434647
97MP0002152_abnormal_brain_morphology0.93084269
98MP0003861_abnormal_nervous_system0.92932061
99MP0005595_abnormal_vascular_smooth0.92588524
100MP0003122_maternal_imprinting0.92309288
101MP0000920_abnormal_myelination0.92192590
102MP0000631_abnormal_neuroendocrine_gland0.91535531
103MP0010030_abnormal_orbit_morphology0.91452989
104MP0003436_decreased_susceptibility_to0.91123774
105MP0001905_abnormal_dopamine_level0.90571132
106MP0002896_abnormal_bone_mineralization0.90030389
107MP0001485_abnormal_pinna_reflex0.89637405
108MP0002932_abnormal_joint_morphology0.86629890
109MP0000762_abnormal_tongue_morphology0.86583946
110MP0002108_abnormal_muscle_morphology0.84457623
111MP0001984_abnormal_olfaction0.83716879
112MP0005257_abnormal_intraocular_pressure0.82667423
113MP0003283_abnormal_digestive_organ0.82475101
114MP0002752_abnormal_somatic_nervous0.82198800
115MP0005187_abnormal_penis_morphology0.81846367
116MP0005248_abnormal_Harderian_gland0.78007237
117MP0000579_abnormal_nail_morphology0.77404302
118MP0002653_abnormal_ependyma_morphology0.76607870
119MP0001849_ear_inflammation0.73830846
120MP0002089_abnormal_postnatal_growth/wei0.73346830
121MP0002139_abnormal_hepatobiliary_system0.72035727
122MP0003045_fibrosis0.71965629
123MP0002419_abnormal_innate_immunity0.70066457
124MP0003566_abnormal_cell_adhesion0.64577129
125MP0002295_abnormal_pulmonary_circulatio0.64565854
126MP0003279_aneurysm0.62943585
127MP0008874_decreased_physiological_sensi0.62926907
128MP0005535_abnormal_body_temperature0.61670058
129MP0006082_CNS_inflammation0.61068522
130MP0006276_abnormal_autonomic_nervous0.59168444
131MP0001502_abnormal_circadian_rhythm0.59004583
132MP0001177_atelectasis0.58977620
133MP0002229_neurodegeneration0.58905318
134MP0005645_abnormal_hypothalamus_physiol0.58845496
135MP0003448_altered_tumor_morphology0.56709744
136MP0003183_abnormal_peptide_metabolism0.56061131
137MP0005387_immune_system_phenotype0.56002127
138MP0001790_abnormal_immune_system0.56002127
139MP0009278_abnormal_bone_marrow0.55043447
140MP0000747_muscle_weakness0.53907685
141MP0004085_abnormal_heartbeat0.53062497

Predicted human phenotypes

RankGene SetZ-score
1Mutism (HP:0002300)4.70640700
2Supranuclear gaze palsy (HP:0000605)4.33882104
3Systemic lupus erythematosus (HP:0002725)4.31776081
4Neurofibrillary tangles (HP:0002185)3.69576489
5Papilledema (HP:0001085)3.61675974
6Protrusio acetabuli (HP:0003179)3.60856011
7Cerebral inclusion bodies (HP:0100314)3.52465352
8Increased cerebral lipofuscin (HP:0011813)3.48953728
9Apathy (HP:0000741)3.40995697
10Disinhibition (HP:0000734)3.39500715
11Visual hallucinations (HP:0002367)3.29658790
12Shallow orbits (HP:0000586)3.23698800
13Myokymia (HP:0002411)3.20532349
14Premature rupture of membranes (HP:0001788)3.19513154
15Morphological abnormality of the middle ear (HP:0008609)3.18504964
16Diminished motivation (HP:0000745)3.15714756
17Neonatal short-limb short stature (HP:0008921)2.98606381
18Inappropriate behavior (HP:0000719)2.92439385
19Dysostosis multiplex (HP:0000943)2.91819878
20Glomerulonephritis (HP:0000099)2.85247512
21Focal seizures (HP:0007359)2.81964004
22Action tremor (HP:0002345)2.79636392
23Aplasia involving bones of the extremities (HP:0009825)2.75488486
24Aplasia involving bones of the upper limbs (HP:0009823)2.75488486
25Aplasia of the phalanges of the hand (HP:0009802)2.75488486
26Short 4th metacarpal (HP:0010044)2.71312948
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71312948
28Mucopolysacchariduria (HP:0008155)2.63094660
29Urinary glycosaminoglycan excretion (HP:0003541)2.63094660
30Abnormality of binocular vision (HP:0011514)2.59829170
31Diplopia (HP:0000651)2.59829170
32Amyotrophic lateral sclerosis (HP:0007354)2.59058939
33Loss of speech (HP:0002371)2.56595744
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.55162931
35Abnormality of the 4th metacarpal (HP:0010012)2.54765584
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.53850581
37Neuronal loss in central nervous system (HP:0002529)2.53338644
38Vascular tortuosity (HP:0004948)2.47135261
39Abnormality of polysaccharide metabolism (HP:0011012)2.46494904
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46494904
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46494904
42Akinesia (HP:0002304)2.45593575
43Complement deficiency (HP:0004431)2.42934375
44Hemiplegia (HP:0002301)2.42898286
45Coronal craniosynostosis (HP:0004440)2.42043222
46Agitation (HP:0000713)2.39790262
47Hypoventilation (HP:0002791)2.38464464
48Ankle clonus (HP:0011448)2.36695540
49Polyphagia (HP:0002591)2.36410203
50Mild short stature (HP:0003502)2.36219040
51Elfin facies (HP:0004428)2.36162429
52Hand muscle atrophy (HP:0009130)2.36057351
53Bowel diverticulosis (HP:0005222)2.35902058
54Abnormality of complement system (HP:0005339)2.35121096
55Torticollis (HP:0000473)2.32266968
56Cerebral aneurysm (HP:0004944)2.31850614
57Enlarged penis (HP:0000040)2.29403012
58Focal motor seizures (HP:0011153)2.27714164
59Obstructive sleep apnea (HP:0002870)2.27149225
60Renal duplication (HP:0000075)2.23430066
61Urinary bladder sphincter dysfunction (HP:0002839)2.22070684
62Renovascular hypertension (HP:0100817)2.22068664
63Termporal pattern (HP:0011008)2.22048377
64Insidious onset (HP:0003587)2.22048377
65Abnormal eating behavior (HP:0100738)2.21811425
66Hyperacusis (HP:0010780)2.19160656
67Overriding aorta (HP:0002623)2.18991925
68Atrophic scars (HP:0001075)2.18273633
69Bronchomalacia (HP:0002780)2.18202695
70Morphological abnormality of the inner ear (HP:0011390)2.16852581
71Hemiparesis (HP:0001269)2.16812366
72Recurrent gram-negative bacterial infections (HP:0005420)2.16531350
73Upper limb amyotrophy (HP:0009129)2.15594710
74Distal upper limb amyotrophy (HP:0007149)2.15594710
75Cortical dysplasia (HP:0002539)2.14952069
76Depression (HP:0000716)2.10875864
77Mitral regurgitation (HP:0001653)2.09947643
78Asymmetric septal hypertrophy (HP:0001670)2.09658964
79Abnormality of the diencephalon (HP:0010662)2.08621579
80Sleep apnea (HP:0010535)2.06372357
81Abnormality of the lower motor neuron (HP:0002366)2.06100460
82Septo-optic dysplasia (HP:0100842)2.06012378
83Abnormality of glycolipid metabolism (HP:0010969)2.05828433
84Abnormality of liposaccharide metabolism (HP:0010968)2.05828433
85Abnormality of glycosphingolipid metabolism (HP:0004343)2.05828433
86Peripheral hypomyelination (HP:0007182)2.05815357
87Insomnia (HP:0100785)2.05473543
88Soft skin (HP:0000977)2.05037702
89Ankle contracture (HP:0006466)2.04975215
90J-shaped sella turcica (HP:0002680)2.03742577
91Cutaneous finger syndactyly (HP:0010554)2.03027668
92Peritonitis (HP:0002586)2.01476461
93Hypoplasia of the iris (HP:0007676)2.00665649
94Drooling (HP:0002307)2.00473305
95Excessive salivation (HP:0003781)2.00473305
96Flat cornea (HP:0007720)1.98891429
97Generalized tonic-clonic seizures (HP:0002069)1.98491776
98Rapidly progressive (HP:0003678)1.98432698
99Turricephaly (HP:0000262)1.97998695
100Abnormality of dentin (HP:0010299)1.97508248
101Megalencephaly (HP:0001355)1.97409447
102Biconcave vertebral bodies (HP:0004586)1.95254689
103Abnormality of the corticospinal tract (HP:0002492)1.94989150
104Postural instability (HP:0002172)1.94796430
105Genetic anticipation (HP:0003743)1.94692289
106Fragile skin (HP:0001030)1.91732180
107Vitreoretinal degeneration (HP:0000655)1.91491856
108Aortic dissection (HP:0002647)1.91200059
109Epileptic encephalopathy (HP:0200134)1.90746020
110Poor eye contact (HP:0000817)1.89492003
111Wide anterior fontanel (HP:0000260)1.88491255
112Spinal rigidity (HP:0003306)1.86695497
113Shawl scrotum (HP:0000049)1.86306587
114Lower limb amyotrophy (HP:0007210)1.86271139
115Impaired social interactions (HP:0000735)1.86108614
116Abnormal social behavior (HP:0012433)1.86108614
117Megalocornea (HP:0000485)1.85366647
118Progressive cerebellar ataxia (HP:0002073)1.84781823
119Cutaneous syndactyly (HP:0012725)1.84090663
120Synostosis of carpal bones (HP:0005048)1.83939147
121Hyperextensible skin (HP:0000974)1.82211804
122Macroorchidism (HP:0000053)1.82173233
123Focal dystonia (HP:0004373)1.80261288
124Aqueductal stenosis (HP:0002410)1.79597152
125Stereotypic behavior (HP:0000733)1.79073195
126Deviation of the hallux (HP:0010051)1.78687213
127Anomalous pulmonary venous return (HP:0010772)1.78683296
128Craniofacial dystonia (HP:0012179)1.77670267
129Subacute progressive viral hepatitis (HP:0006572)1.77396136
130Broad metatarsal (HP:0001783)1.77220246
131Wrist flexion contracture (HP:0001239)1.76873353
132Truncal ataxia (HP:0002078)1.76132900
133Wormian bones (HP:0002645)1.75954571
134Polygenic inheritance (HP:0010982)1.74529113
135Abnormality of the pulmonary veins (HP:0011718)1.73911577
136Arterial tortuosity (HP:0005116)1.73826362
137Hallux valgus (HP:0001822)1.73636390
138Nephritis (HP:0000123)1.73108333
139Increased corneal curvature (HP:0100692)1.72783086
140Keratoconus (HP:0000563)1.72783086
141Abnormality of the middle phalanges of the toes (HP:0010183)1.71742877
142Dementia (HP:0000726)1.70750892
143Urinary urgency (HP:0000012)1.70574532
144Ulnar bowing (HP:0003031)1.70434042
145Mitral valve prolapse (HP:0001634)1.70239283
146Tibial bowing (HP:0002982)1.69531153
147Absence seizures (HP:0002121)1.68424043
148Limb dystonia (HP:0002451)1.67213739
149Increased variability in muscle fiber diameter (HP:0003557)1.65002230
150Bladder diverticulum (HP:0000015)1.63906978
151Lymphangioma (HP:0100764)1.63797723
152Vacuolated lymphocytes (HP:0001922)1.63514895
153Overgrowth (HP:0001548)1.63421441
154Confusion (HP:0001289)1.63333548
155Progressive inability to walk (HP:0002505)1.62986768
156Vertebral arch anomaly (HP:0008438)1.62779864
157Myotonia (HP:0002486)1.62578181
158Genu recurvatum (HP:0002816)1.62400148
159Bowing of the arm (HP:0006488)1.61306973
160Bowed forearm bones (HP:0003956)1.61306973
161Arnold-Chiari malformation (HP:0002308)1.59319200
162Anxiety (HP:0000739)1.57286791
163Partial duplication of the phalanx of hand (HP:0009999)1.56507591
164Intention tremor (HP:0002080)1.56506205
165Aortic regurgitation (HP:0001659)1.55604458
166Heterochromia iridis (HP:0001100)1.52703435
167Venous insufficiency (HP:0005293)1.52120718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.71061618
2MAP3K93.48156561
3CASK2.95913239
4TRIB32.69063347
5DAPK22.57679579
6CAMKK12.27706127
7MINK12.23476514
8RIPK12.17056911
9PHKG22.16947766
10PHKG12.16947766
11PKN22.11005240
12PAK62.08915946
13NTRK22.04426064
14NTRK31.99015584
15TNIK1.95901458
16LATS21.88413520
17SIK21.79393438
18NTRK11.78754947
19PRKD21.67825448
20KSR21.64648404
21MAP3K41.60449253
22CAMK1G1.56128117
23PRKD31.30836667
24RET1.28719311
25CAMK1D1.25932224
26TAOK11.24568580
27EPHB21.22458924
28ERN11.22167630
29SCYL21.21203524
30PRKCH1.20722582
31CAMKK21.20027528
32MAP2K41.19774580
33CDK51.19472020
34ERBB31.17310617
35MST1R1.16717625
36RIPK41.16416265
37BMX1.16223684
38STK381.14728289
39KSR11.13942112
40SGK2231.11761187
41SGK4941.11761187
42MOS1.11075033
43FES1.10051741
44CAMK2B1.06506202
45DYRK21.06480694
46EPHA41.04802295
47MAP2K71.03753491
48ROCK21.03716328
49ALK1.01414074
50PLK21.01180597
51ERBB41.00184200
52MAPK130.96621184
53PTK60.96301149
54PAK20.95072734
55TTN0.94336184
56RPS6KA20.94181913
57EPHA30.93611962
58PDGFRA0.92307967
59FGFR20.91588126
60TYRO30.90519157
61MAP3K20.88012476
62PINK10.85850735
63DDR20.85824857
64LMTK20.85685036
65DAPK10.84086223
66SGK20.83120453
67PAK30.82986311
68CAMK2G0.82557837
69CSNK1G20.81978997
70FGR0.75486825
71MARK20.74934670
72LIMK10.74849737
73PNCK0.73137521
74PRKCG0.72939380
75MAPK120.72325686
76GRK50.71024906
77STK110.70827010
78PRKCZ0.69452551
79BLK0.69032556
80PKN10.68327236
81MTOR0.65359336
82CDK140.64672973
83* FYN0.64187296
84ICK0.63759649
85CDK150.63219749
86CAMK10.60983224
87ARAF0.60249182
88CDK180.59906814
89DMPK0.59325659
90JAK10.58990225
91CAMK2D0.57673093
92SGK10.55707071
93PRKD10.55340634
94MAPK40.54441344
95ROCK10.54048213
96CSNK1A1L0.53734965
97MAPK100.52093899
98TBK10.51788900
99FGFR40.50738007
100CDK11A0.50565551
101HCK0.50464289
102GRK10.49316476
103NEK60.48548696
104CSNK1G30.48413158
105PDPK10.47720803
106ABL20.47637307
107ERBB20.46885311
108MAP3K10.46488063
109EGFR0.45496325
110UHMK10.45388849
111DYRK1A0.44499648
112SGK30.43968773
113DAPK30.43385472
114TESK10.43109862
115MUSK0.42896437
116PRPF4B0.42817556
117EPHB10.42723758
118SRC0.41067519
119CAMK2A0.40804216
120PDGFRB0.40520602
121PRKCE0.39894871
122PDK10.39563593
123PTK20.39142756
124CDC42BPA0.38807159
125KIT0.38766032
126PTK2B0.38664782
127JAK20.38502892
128NEK90.38022678
129SIK10.38008379
130CSNK1G10.37830381
131FGFR30.37385381
132RPS6KA30.36356745
133MAPKAPK50.35579357
134EEF2K0.35322343
135RPS6KL10.34079191
136RPS6KC10.34079191

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.11051657
2Staphylococcus aureus infection_Homo sapiens_hsa051502.06880012
3Olfactory transduction_Homo sapiens_hsa047401.96994035
4ECM-receptor interaction_Homo sapiens_hsa045121.92485167
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85318588
6Circadian entrainment_Homo sapiens_hsa047131.62710409
7GABAergic synapse_Homo sapiens_hsa047271.60818865
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.56144703
9Nicotine addiction_Homo sapiens_hsa050331.50698412
10Glutamatergic synapse_Homo sapiens_hsa047241.49835594
11Basal cell carcinoma_Homo sapiens_hsa052171.49100333
12Morphine addiction_Homo sapiens_hsa050321.45599358
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45584384
14Nitrogen metabolism_Homo sapiens_hsa009101.44442927
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41420528
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37516574
17Long-term potentiation_Homo sapiens_hsa047201.36928235
18Cholinergic synapse_Homo sapiens_hsa047251.35769526
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34306676
20Protein digestion and absorption_Homo sapiens_hsa049741.33865574
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33506401
22Dopaminergic synapse_Homo sapiens_hsa047281.32474084
23Axon guidance_Homo sapiens_hsa043601.32209455
24Hedgehog signaling pathway_Homo sapiens_hsa043401.28528763
25Lysosome_Homo sapiens_hsa041421.28136790
26Salivary secretion_Homo sapiens_hsa049701.27138313
27Type II diabetes mellitus_Homo sapiens_hsa049301.23839722
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23585611
29Glioma_Homo sapiens_hsa052141.22651238
30Gastric acid secretion_Homo sapiens_hsa049711.22428917
31Prion diseases_Homo sapiens_hsa050201.21517273
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20096011
33Melanoma_Homo sapiens_hsa052181.19668219
34Pertussis_Homo sapiens_hsa051331.18942659
35Hippo signaling pathway_Homo sapiens_hsa043901.17303136
36Notch signaling pathway_Homo sapiens_hsa043301.16611154
37Renin secretion_Homo sapiens_hsa049241.15633981
38Estrogen signaling pathway_Homo sapiens_hsa049151.13015552
39Gap junction_Homo sapiens_hsa045401.12693044
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12621604
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09428587
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.09402914
43Insulin secretion_Homo sapiens_hsa049111.08789193
44Oxytocin signaling pathway_Homo sapiens_hsa049211.07467427
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05222659
46GnRH signaling pathway_Homo sapiens_hsa049121.05060565
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03143862
48Ras signaling pathway_Homo sapiens_hsa040141.00206887
49Wnt signaling pathway_Homo sapiens_hsa043100.99948629
50Amphetamine addiction_Homo sapiens_hsa050310.99466374
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99022899
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98496823
53Cocaine addiction_Homo sapiens_hsa050300.98394627
54Long-term depression_Homo sapiens_hsa047300.96221527
55Amoebiasis_Homo sapiens_hsa051460.94981957
56Tuberculosis_Homo sapiens_hsa051520.94348417
57Thyroid hormone synthesis_Homo sapiens_hsa049180.94275620
58Endometrial cancer_Homo sapiens_hsa052130.93013766
59Phagosome_Homo sapiens_hsa041450.91424647
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90806326
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90428820
62Chemokine signaling pathway_Homo sapiens_hsa040620.90383919
63Dilated cardiomyopathy_Homo sapiens_hsa054140.89981517
64Other glycan degradation_Homo sapiens_hsa005110.89114985
65Renal cell carcinoma_Homo sapiens_hsa052110.89002324
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87767480
67Dorso-ventral axis formation_Homo sapiens_hsa043200.86902134
68Leishmaniasis_Homo sapiens_hsa051400.86508704
69Osteoclast differentiation_Homo sapiens_hsa043800.85893165
70VEGF signaling pathway_Homo sapiens_hsa043700.85752784
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.85348959
72Serotonergic synapse_Homo sapiens_hsa047260.85139052
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84835807
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.84365206
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83926921
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83616905
77Complement and coagulation cascades_Homo sapiens_hsa046100.82872861
78ErbB signaling pathway_Homo sapiens_hsa040120.82592812
79cAMP signaling pathway_Homo sapiens_hsa040240.82591918
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80589979
81Viral myocarditis_Homo sapiens_hsa054160.80097864
82Colorectal cancer_Homo sapiens_hsa052100.79505999
83MicroRNAs in cancer_Homo sapiens_hsa052060.79331761
84Endocytosis_Homo sapiens_hsa041440.78725305
85B cell receptor signaling pathway_Homo sapiens_hsa046620.76459385
86Melanogenesis_Homo sapiens_hsa049160.76023936
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75299184
88Cardiac muscle contraction_Homo sapiens_hsa042600.74961494
89Focal adhesion_Homo sapiens_hsa045100.73241378
90mTOR signaling pathway_Homo sapiens_hsa041500.72597025
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.71677564
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71498997
93* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71230314
94Bile secretion_Homo sapiens_hsa049760.71211789
95Adherens junction_Homo sapiens_hsa045200.70560608
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70339450
97Salmonella infection_Homo sapiens_hsa051320.70006071
98Calcium signaling pathway_Homo sapiens_hsa040200.68993173
99Platelet activation_Homo sapiens_hsa046110.68586051
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68421635
101Rap1 signaling pathway_Homo sapiens_hsa040150.68013339
102Tight junction_Homo sapiens_hsa045300.67504278
103Proteoglycans in cancer_Homo sapiens_hsa052050.66698342
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66657090
105Chronic myeloid leukemia_Homo sapiens_hsa052200.66645880
106Pancreatic cancer_Homo sapiens_hsa052120.66330672
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65001397
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63433580
109Pathways in cancer_Homo sapiens_hsa052000.62781678
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62753103
111Choline metabolism in cancer_Homo sapiens_hsa052310.62523287
112Insulin signaling pathway_Homo sapiens_hsa049100.61398453
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61363366
114Malaria_Homo sapiens_hsa051440.60970837
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60691905
116MAPK signaling pathway_Homo sapiens_hsa040100.60678600
117Vibrio cholerae infection_Homo sapiens_hsa051100.59699884
118Non-small cell lung cancer_Homo sapiens_hsa052230.59394277
119PPAR signaling pathway_Homo sapiens_hsa033200.58406478
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58018152
121Pancreatic secretion_Homo sapiens_hsa049720.57906057
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57471465
123Insulin resistance_Homo sapiens_hsa049310.57378553
124Prolactin signaling pathway_Homo sapiens_hsa049170.54827191
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53336878
126Taste transduction_Homo sapiens_hsa047420.52950230
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52621373
128Phototransduction_Homo sapiens_hsa047440.50165169
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46519254
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45347891
131Vitamin B6 metabolism_Homo sapiens_hsa007500.44236913
132AMPK signaling pathway_Homo sapiens_hsa041520.44033116

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