SDCBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.05240803
2modulation by symbiont of host defense response (GO:0052031)5.57050586
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.57050586
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.57050586
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.57050586
6modulation by symbiont of host immune response (GO:0052553)5.57050586
7positive regulation by symbiont of host defense response (GO:0052509)5.57050586
8neutrophil activation involved in immune response (GO:0002283)5.38497199
9response to peptidoglycan (GO:0032494)4.51944848
10regulation of interferon-beta biosynthetic process (GO:0045357)4.49990557
11macrophage activation involved in immune response (GO:0002281)4.33077032
12regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.16885834
13positive regulation of gamma-delta T cell activation (GO:0046645)4.10894041
14response to host immune response (GO:0052572)4.08734028
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.08734028
16respiratory burst (GO:0045730)4.06644706
17negative regulation of interleukin-12 production (GO:0032695)4.03164644
18positive regulation of interferon-alpha production (GO:0032727)3.97714703
19platelet dense granule organization (GO:0060155)3.96687212
20microglial cell activation (GO:0001774)3.91377996
21immunoglobulin mediated immune response (GO:0016064)3.91312001
22Arp2/3 complex-mediated actin nucleation (GO:0034314)3.86846816
23regulation of B cell receptor signaling pathway (GO:0050855)3.80228794
24regulation of interferon-alpha production (GO:0032647)3.78068641
25production of molecular mediator involved in inflammatory response (GO:0002532)3.68684519
26myeloid cell activation involved in immune response (GO:0002275)3.68201447
27response to host (GO:0075136)3.66072778
28response to host defenses (GO:0052200)3.66072778
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.66072778
30positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.52058144
31cellular response to thyroid hormone stimulus (GO:0097067)3.50320529
32detection of other organism (GO:0098543)3.50216464
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49794783
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49794783
35neutrophil activation (GO:0042119)3.47346527
36detection of external biotic stimulus (GO:0098581)3.46427357
37positive regulation of B cell differentiation (GO:0045579)3.46236442
38regulation of chemokine biosynthetic process (GO:0045073)3.43711168
39granulocyte activation (GO:0036230)3.43171016
40negative regulation of interleukin-17 production (GO:0032700)3.42194678
41regulation of interleukin-8 biosynthetic process (GO:0045414)3.40099000
42B cell mediated immunity (GO:0019724)3.39828332
43regulation of mast cell activation (GO:0033003)3.37066999
44macrophage activation (GO:0042116)3.33946010
45response to interferon-beta (GO:0035456)3.30322115
46antigen processing and presentation of endogenous antigen (GO:0019883)3.30198256
47defense response to protozoan (GO:0042832)3.28402844
48lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27646071
49regulation of cytokine secretion involved in immune response (GO:0002739)3.25577552
50negative regulation of interleukin-1 beta production (GO:0032691)3.22819250
51negative regulation of mast cell activation (GO:0033004)3.21573148
52actin nucleation (GO:0045010)3.19463772
53positive regulation of cellular amide metabolic process (GO:0034250)3.18979194
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17991808
55regulation of mast cell degranulation (GO:0043304)3.16188619
56positive regulation of antigen processing and presentation (GO:0002579)3.14638415
57detection of molecule of bacterial origin (GO:0032490)3.14276846
58positive regulation of macrophage differentiation (GO:0045651)3.12237955
59phagosome maturation (GO:0090382)3.11927091
60neutrophil mediated immunity (GO:0002446)3.11773333
61positive regulation of chemokine biosynthetic process (GO:0045080)3.11041204
62positive regulation of mast cell activation (GO:0033005)3.10301757
63negative regulation of interleukin-1 production (GO:0032692)3.07505222
64response to protozoan (GO:0001562)3.07400078
65response to interferon-alpha (GO:0035455)3.06139749
66mast cell activation (GO:0045576)3.05115623
67proteasome assembly (GO:0043248)3.04732664
68negative regulation of production of molecular mediator of immune response (GO:0002701)3.04688722
69leukocyte migration involved in inflammatory response (GO:0002523)3.03642251
70melanin biosynthetic process (GO:0042438)3.02533192
71positive regulation of toll-like receptor signaling pathway (GO:0034123)3.01065843
72positive regulation of natural killer cell differentiation (GO:0032825)3.01021286
73regulation of mast cell activation involved in immune response (GO:0033006)2.99430259
74positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99179527
75negative regulation of erythrocyte differentiation (GO:0045647)2.98993395
76type I interferon signaling pathway (GO:0060337)2.98440185
77cellular response to type I interferon (GO:0071357)2.98440185
78interferon-gamma-mediated signaling pathway (GO:0060333)2.98102815
79negative regulation of cell killing (GO:0031342)2.97146781
80negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97146781
81phagocytosis, engulfment (GO:0006911)2.97118678
82detection of biotic stimulus (GO:0009595)2.96785567
83myeloid leukocyte activation (GO:0002274)2.95702344
84response to type I interferon (GO:0034340)2.95655661
85superoxide anion generation (GO:0042554)2.94482107
86negative regulation of myeloid cell apoptotic process (GO:0033033)2.93340750
87regulation of B cell differentiation (GO:0045577)2.92180762
88cellular extravasation (GO:0045123)2.92145435
89myeloid dendritic cell activation (GO:0001773)2.91859102
90endosome to melanosome transport (GO:0035646)2.91031084
91endosome to pigment granule transport (GO:0043485)2.91031084
92positive regulation of interferon-beta production (GO:0032728)2.89416665
93regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.88838893
94response to lipoprotein particle (GO:0055094)2.88183091
95secondary metabolite biosynthetic process (GO:0044550)2.87576318
96cellular response to interferon-beta (GO:0035458)2.87553199
97membrane invagination (GO:0010324)2.87239964
98detection of bacterium (GO:0016045)2.84730020
99response to xenobiotic stimulus (GO:0009410)2.83976066
100angiogenesis involved in wound healing (GO:0060055)2.82999067
101leukocyte mediated cytotoxicity (GO:0001909)2.82863412
102cytokine secretion (GO:0050663)2.80470433
103leukocyte degranulation (GO:0043299)2.79873370
104phospholipid homeostasis (GO:0055091)2.79658172
105Rap protein signal transduction (GO:0032486)2.79223405
106regulation of mononuclear cell migration (GO:0071675)2.77031856
107positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.74960686
108negative regulation of cytokine production involved in immune response (GO:0002719)2.74380210
109positive regulation of mast cell degranulation (GO:0043306)2.74305465
110positive regulation of mast cell activation involved in immune response (GO:0033008)2.74305465
111regulation of antigen processing and presentation (GO:0002577)2.74027871
112myeloid dendritic cell differentiation (GO:0043011)2.73264188
113positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.70849914
114interferon-gamma production (GO:0032609)2.70766004
115dendritic cell migration (GO:0036336)2.69234523
116positive regulation of interleukin-1 beta secretion (GO:0050718)2.68122110
117antigen processing and presentation via MHC class Ib (GO:0002475)2.66392811
118definitive hemopoiesis (GO:0060216)2.65929809
119amino sugar catabolic process (GO:0046348)2.64859775
120oligosaccharide catabolic process (GO:0009313)2.64774095
121negative regulation of phagocytosis (GO:0050765)2.64550398
122neutrophil chemotaxis (GO:0030593)2.63667714
123histamine secretion (GO:0001821)2.63474786
124positive regulation of interleukin-6 production (GO:0032755)2.63455685
125positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.62483913
126leukocyte aggregation (GO:0070486)2.62019851
127dendritic cell differentiation (GO:0097028)2.61209761
128regulation of interleukin-1 beta secretion (GO:0050706)2.59554533
129natural killer cell mediated cytotoxicity (GO:0042267)2.59473442
130natural killer cell mediated immunity (GO:0002228)2.59473442
131negative regulation of viral genome replication (GO:0045071)2.59270029
132signal peptide processing (GO:0006465)2.58318541
133positive regulation of interleukin-1 secretion (GO:0050716)2.57194113
134response to muramyl dipeptide (GO:0032495)2.56558686
135neutrophil migration (GO:1990266)2.56397512
136myeloid leukocyte mediated immunity (GO:0002444)2.56181335
137positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.56008544
138negative regulation of lymphocyte mediated immunity (GO:0002707)2.55819623
139melanin metabolic process (GO:0006582)2.55466454
140positive regulation of NF-kappaB import into nucleus (GO:0042346)2.54872749
141keratan sulfate catabolic process (GO:0042340)2.54555911
142response to thyroid hormone (GO:0097066)2.51068912
143positive regulation of monocyte chemotaxis (GO:0090026)2.49975284
144intracellular pH reduction (GO:0051452)2.49075051
145T-helper 1 type immune response (GO:0042088)2.48434051
146positive regulation of macrophage cytokine production (GO:0060907)2.47741070
147regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.47470482
148glycosphingolipid catabolic process (GO:0046479)2.43689652
149regulation of heat generation (GO:0031650)2.41143976
150regulation of podosome assembly (GO:0071801)2.38273094
151negative regulation of lipid storage (GO:0010888)2.37697341
152regulation of fever generation (GO:0031620)2.37535726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.19601707
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.08375261
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.07890759
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.05143361
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.00672960
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.98147572
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.93031989
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.57541476
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.55426340
10GATA1_22025678_ChIP-Seq_K562_Human3.51924221
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34813207
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.28711455
13* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.26599409
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.90303214
15SCL_19346495_ChIP-Seq_HPC-7_Human2.81507694
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.80551698
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72022429
18SPI1_23547873_ChIP-Seq_NB4_Human2.51464609
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49572453
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47102024
21* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35102706
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28817405
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26270781
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.21362908
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17758547
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11737121
27* GATA2_21666600_ChIP-Seq_HMVEC_Human2.07986479
28* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05348101
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00242606
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.98931745
31RUNX_20019798_ChIP-Seq_JUKART_Human1.94105189
32* MYB_26560356_Chip-Seq_TH2_Human1.90115377
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87786484
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82631791
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.82365436
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82121624
37PU_27001747_Chip-Seq_BMDM_Mouse1.77181082
38SPI1_23127762_ChIP-Seq_K562_Human1.76804946
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74549987
40P300_19829295_ChIP-Seq_ESCs_Human1.74390278
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72137569
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70025486
43VDR_24763502_ChIP-Seq_THP-1_Human1.69332017
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.55405482
45* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54612254
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53859039
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52420767
48* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50902086
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50547729
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50475724
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49284945
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.49023115
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47063947
54VDR_24787735_ChIP-Seq_THP-1_Human1.46590586
55* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45418900
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40418646
57TAF15_26573619_Chip-Seq_HEK293_Human1.39952460
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39518454
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39038565
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.38490100
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.34153729
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33321512
63MYB_26560356_Chip-Seq_TH1_Human1.33311319
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31680546
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31548447
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30828981
67GATA3_27048872_Chip-Seq_THYMUS_Human1.29435116
68* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29297814
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27898165
70* SOX2_20726797_ChIP-Seq_SW620_Human1.27274337
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26459426
72* GATA3_26560356_Chip-Seq_TH2_Human1.25982171
73MAF_26560356_Chip-Seq_TH1_Human1.25597665
74* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24988302
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23264570
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22784252
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22075201
78ELK1_19687146_ChIP-ChIP_HELA_Human1.20987184
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.17493947
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17325310
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17253112
82SALL4_22934838_ChIP-ChIP_CD34+_Human1.16162312
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15128718
84BCAT_22108803_ChIP-Seq_LS180_Human1.15072136
85* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14850046
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14742649
87EWS_26573619_Chip-Seq_HEK293_Human1.14000084
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13266724
89CDX2_22108803_ChIP-Seq_LS180_Human1.12473550
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.12347915
91ZNF274_21170338_ChIP-Seq_K562_Hela1.10743632
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10083630
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.09675166
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.09316698
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08477568
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08295224
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07839449
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06735882
99TFEB_21752829_ChIP-Seq_HELA_Human1.06558636
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06158251
101SOX2_19829295_ChIP-Seq_ESCs_Human1.05711953
102NANOG_19829295_ChIP-Seq_ESCs_Human1.05711953
103GBX2_23144817_ChIP-Seq_PC3_Human1.05681876
104* BRD4_25478319_ChIP-Seq_HGPS_Human1.04252575
105* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03567337
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.03466224
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03323948
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03323948
109VDR_22108803_ChIP-Seq_LS180_Human1.03265153
110TP53_16413492_ChIP-PET_HCT116_Human1.02743164
111* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02621513
112ER_23166858_ChIP-Seq_MCF-7_Human1.02490418
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.01988001
114VDR_21846776_ChIP-Seq_THP-1_Human1.01806795
115GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01020049
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00513019
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00361713
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.00126258
119TCF4_22108803_ChIP-Seq_LS180_Human0.99695549
120SMAD3_21741376_ChIP-Seq_EPCs_Human0.98887714
121SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97881252
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97373457
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97295415
124P53_22387025_ChIP-Seq_ESCs_Mouse0.95816073
125RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95526747
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94809025
127FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94729882
128* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94164723
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93372558
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93339870
131CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92993868
132IGF1R_20145208_ChIP-Seq_DFB_Human0.92656439
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92307511
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92304408
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92138244
136* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91091902
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90304747
138E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89682893
139CJUN_26792858_Chip-Seq_BT549_Human0.89189453
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.88892848
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88054248
142ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87436479
143NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86293100
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84001308
145SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84001308
146GATA1_19941827_ChIP-Seq_MEL_Mouse0.82965411
147UTX_26944678_Chip-Seq_JUKART_Human0.81273169
148SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81148652
149EGR1_19032775_ChIP-ChIP_M12_Human0.80128928
150GATA2_19941826_ChIP-Seq_K562_Human0.75966481
151KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.75345193
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74715511
153IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74562825
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72341223
155RARG_19884340_ChIP-ChIP_MEFs_Mouse0.71122759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.11704025
2MP0003724_increased_susceptibility_to3.43409831
3MP0009785_altered_susceptibility_to3.31885942
4MP0003436_decreased_susceptibility_to3.27253642
5MP0002148_abnormal_hypersensitivity_rea3.24704674
6MP0005058_abnormal_lysosome_morphology3.19485372
7MP0002419_abnormal_innate_immunity3.02753593
8MP0005000_abnormal_immune_tolerance2.83814333
9MP0005464_abnormal_platelet_physiology2.60067779
10MP0005025_abnormal_response_to2.59489483
11MP0006082_CNS_inflammation2.46762398
12MP0003303_peritoneal_inflammation2.44621705
13MP0002452_abnormal_antigen_presenting2.38810120
14MP0005671_abnormal_response_to2.37375897
15MP0005408_hypopigmentation2.32952030
16MP0003172_abnormal_lysosome_physiology2.27888335
17MP0004510_myositis2.25155173
18MP0002723_abnormal_immune_serum2.17570623
19MP0005248_abnormal_Harderian_gland2.17291710
20MP0001819_abnormal_immune_cell2.12564402
21MP0002420_abnormal_adaptive_immunity2.11405990
22MP0003806_abnormal_nucleotide_metabolis2.07818370
23MP0005387_immune_system_phenotype2.05401162
24MP0001790_abnormal_immune_system2.05401162
25MP0005075_abnormal_melanosome_morpholog2.04976898
26MP0001800_abnormal_humoral_immune2.03055566
27MP0006054_spinal_hemorrhage1.99917412
28MP0000343_altered_response_to1.99847361
29MP0003195_calcinosis1.99372519
30MP0003136_yellow_coat_color1.97125921
31MP0001533_abnormal_skeleton_physiology1.97049171
32MP0000685_abnormal_immune_system1.94424951
33MP0005397_hematopoietic_system_phenotyp1.84745387
34MP0001545_abnormal_hematopoietic_system1.84745387
35MP0001853_heart_inflammation1.80672048
36MP0003183_abnormal_peptide_metabolism1.77568631
37MP0001845_abnormal_inflammatory_respons1.74350829
38MP0000372_irregular_coat_pigmentation1.73979871
39MP0002405_respiratory_system_inflammati1.68991495
40MP0005167_abnormal_blood-brain_barrier1.66547808
41MP0005174_abnormal_tail_pigmentation1.63466043
42MP0000569_abnormal_digit_pigmentation1.60795649
43MP0000465_gastrointestinal_hemorrhage1.60712974
44MP0002006_tumorigenesis1.59207376
45MP0010155_abnormal_intestine_physiology1.58259631
46MP0003300_gastrointestinal_ulcer1.57083376
47MP0002166_altered_tumor_susceptibility1.54252718
48MP0002398_abnormal_bone_marrow1.52661582
49MP0009333_abnormal_splenocyte_physiolog1.51994941
50MP0009764_decreased_sensitivity_to1.51965271
51MP0000716_abnormal_immune_system1.51398413
52MP0004808_abnormal_hematopoietic_stem1.51220443
53MP0000015_abnormal_ear_pigmentation1.46426194
54MP0005310_abnormal_salivary_gland1.44394133
55MP0002396_abnormal_hematopoietic_system1.44131945
56MP0002090_abnormal_vision1.42780932
57MP0009840_abnormal_foam_cell1.42289854
58MP0003448_altered_tumor_morphology1.41403941
59MP0004381_abnormal_hair_follicle1.40781879
60MP0008469_abnormal_protein_level1.40459328
61MP0002998_abnormal_bone_remodeling1.39766607
62MP0003075_altered_response_to1.38505998
63MP0004947_skin_inflammation1.38293563
64MP0003191_abnormal_cellular_cholesterol1.37852706
65MP0009278_abnormal_bone_marrow1.36695885
66MP0001324_abnormal_eye_pigmentation1.36525649
67MP0000689_abnormal_spleen_morphology1.34958173
68MP0002132_abnormal_respiratory_system1.34645425
69MP0000858_altered_metastatic_potential1.33189217
70MP0001986_abnormal_taste_sensitivity1.32173226
71MP0002933_joint_inflammation1.29510903
72MP0003656_abnormal_erythrocyte_physiolo1.29478940
73MP0005164_abnormal_response_to1.29425302
74MP0002429_abnormal_blood_cell1.28851777
75MP0005166_decreased_susceptibility_to1.27229620
76MP0002102_abnormal_ear_morphology1.27010858
77MP0010386_abnormal_urinary_bladder1.25276459
78MP0002722_abnormal_immune_system1.16231602
79MP0005171_absent_coat_pigmentation1.13826797
80MP0001879_abnormal_lymphatic_vessel1.13101104
81MP0003221_abnormal_cardiomyocyte_apopto1.12604511
82MP0004782_abnormal_surfactant_physiolog1.12601151
83MP0003828_pulmonary_edema1.11049900
84MP0004147_increased_porphyrin_level1.08933835
85MP0004883_abnormal_blood_vessel1.05284118
86MP0003279_aneurysm1.03700765
87MP0005257_abnormal_intraocular_pressure1.03229773
88MP0001958_emphysema1.03150267
89MP0002095_abnormal_skin_pigmentation1.02673153
90MP0003011_delayed_dark_adaptation1.01297587
91MP0000249_abnormal_blood_vessel1.00701969
92MP0008260_abnormal_autophagy0.99789694
93MP0004484_altered_response_of0.99430204
94MP0002877_abnormal_melanocyte_morpholog0.98663511
95MP0002332_abnormal_exercise_endurance0.97998159
96MP0005390_skeleton_phenotype0.96792034
97MP0003866_abnormal_defecation0.95812287
98MP0008004_abnormal_stomach_pH0.95468364
99MP0000604_amyloidosis0.95333638
100MP0005367_renal/urinary_system_phenotyp0.95027701
101MP0000516_abnormal_urinary_system0.95027701
102MP0000490_abnormal_crypts_of0.94496665
103MP0001873_stomach_inflammation0.94227082
104MP0000681_abnormal_thyroid_gland0.91556371
105MP0003186_abnormal_redox_activity0.88400007
106MP0005253_abnormal_eye_physiology0.85879158
107MP0003795_abnormal_bone_structure0.84505816
108MP0001851_eye_inflammation0.82975624
109MP0001663_abnormal_digestive_system0.80240795
110MP0000920_abnormal_myelination0.80228979
111MP0003763_abnormal_thymus_physiology0.79458491
112MP0000371_diluted_coat_color0.79457652
113MP0005647_abnormal_sex_gland0.79415506
114MP0001764_abnormal_homeostasis0.78996114
115MP0003690_abnormal_glial_cell0.78292655
116MP0002277_abnormal_respiratory_mucosa0.77632614
117MP0009763_increased_sensitivity_to0.75696398
118MP0002735_abnormal_chemical_nociception0.75448928
119MP0003943_abnormal_hepatobiliary_system0.74836877
120MP0002075_abnormal_coat/hair_pigmentati0.73947425
121MP0003890_abnormal_embryonic-extraembry0.73538530
122MP0000767_abnormal_smooth_muscle0.72469807
123MP0001186_pigmentation_phenotype0.71899178
124MP0002254_reproductive_system_inflammat0.71889438
125MP0009697_abnormal_copulation0.70465611
126MP0002138_abnormal_hepatobiliary_system0.70022510
127MP0001915_intracranial_hemorrhage0.68723907
128MP0003566_abnormal_cell_adhesion0.68423953
129MP0005165_increased_susceptibility_to0.68323129
130MP0002139_abnormal_hepatobiliary_system0.66529748
131MP0005376_homeostasis/metabolism_phenot0.62417796
132MP0009765_abnormal_xenobiotic_induced0.56982547

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.53415584
2Recurrent bacterial skin infections (HP:0005406)5.62323017
3Eczematoid dermatitis (HP:0000976)5.55724160
4Increased cerebral lipofuscin (HP:0011813)5.18382303
5Increased neuronal autofluorescent lipopigment (HP:0002074)5.10840552
6Vacuolated lymphocytes (HP:0001922)5.03458504
7Abnormality of macrophages (HP:0004311)4.65460845
8Recurrent gram-negative bacterial infections (HP:0005420)4.24872689
9Myositis (HP:0100614)4.17276089
10Elevated erythrocyte sedimentation rate (HP:0003565)3.84165371
11Dysostosis multiplex (HP:0000943)3.79264187
12Interstitial pulmonary disease (HP:0006530)3.54896165
13Orchitis (HP:0100796)3.53451961
14Mediastinal lymphadenopathy (HP:0100721)3.45466078
15Petechiae (HP:0000967)3.43765466
16Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.33819587
17Optic neuritis (HP:0100653)3.29271002
18Retrobulbar optic neuritis (HP:0100654)3.29271002
19Albinism (HP:0001022)3.25890209
20Urinary glycosaminoglycan excretion (HP:0003541)3.25122922
21Mucopolysacchariduria (HP:0008155)3.25122922
22Recurrent skin infections (HP:0001581)3.24838968
23Systemic lupus erythematosus (HP:0002725)3.18780330
24Gingivitis (HP:0000230)3.18279015
25Chronic obstructive pulmonary disease (HP:0006510)3.16716310
26Obstructive lung disease (HP:0006536)3.16716310
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.13849994
28Stomatitis (HP:0010280)2.97396345
29Aplasia/Hypoplasia of the fovea (HP:0008060)2.96430307
30Hypoplasia of the fovea (HP:0007750)2.96430307
31Abnormality of glycolipid metabolism (HP:0010969)2.96334940
32Abnormality of liposaccharide metabolism (HP:0010968)2.96334940
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.96334940
34Hypothermia (HP:0002045)2.95460471
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.94241894
36Abnormality of polysaccharide metabolism (HP:0011012)2.94241894
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.94241894
38Keratoconjunctivitis (HP:0001096)2.88400106
39Mutism (HP:0002300)2.84392729
40Recurrent fungal infections (HP:0002841)2.84120104
41Amyloidosis (HP:0011034)2.82705569
42Myocardial infarction (HP:0001658)2.81824908
43Cellulitis (HP:0100658)2.79943824
44IgM deficiency (HP:0002850)2.79421652
45Disinhibition (HP:0000734)2.73981679
46Autoimmune thrombocytopenia (HP:0001973)2.73893656
47Aplasia/Hypoplasia of the macula (HP:0008059)2.70632103
48Chronic otitis media (HP:0000389)2.64973188
49Nuclear cataract (HP:0100018)2.64062544
50Agnosia (HP:0010524)2.62130575
51Vasculitis (HP:0002633)2.59457421
52Abnormality of the fovea (HP:0000493)2.58930040
53Prolonged bleeding time (HP:0003010)2.57429320
54Vertebral compression fractures (HP:0002953)2.56150698
55Osteomyelitis (HP:0002754)2.55313374
56Axonal loss (HP:0003447)2.48590160
57Spontaneous hematomas (HP:0007420)2.47619131
58Ocular albinism (HP:0001107)2.46511587
59Hematochezia (HP:0002573)2.46455127
60T lymphocytopenia (HP:0005403)2.45193393
61Aplasia/Hypoplasia affecting the retina (HP:0008061)2.43871178
62Periodontitis (HP:0000704)2.39465780
63Prostate neoplasm (HP:0100787)2.39446784
64Abnormality of T cell number (HP:0011839)2.38436334
65Increased CSF protein (HP:0002922)2.38395686
66Basal ganglia calcification (HP:0002135)2.38296927
67Thrombocytosis (HP:0001894)2.37999303
68Pustule (HP:0200039)2.36912246
69Recurrent viral infections (HP:0004429)2.32556369
70Meningitis (HP:0001287)2.30510023
71Generalized hypopigmentation (HP:0007513)2.30398603
72Beaking of vertebral bodies (HP:0004568)2.30256404
73Loss of speech (HP:0002371)2.28067854
74Abnormality of the lumbar spine (HP:0100712)2.27931870
75Abnormal platelet function (HP:0011869)2.27391920
76Impaired platelet aggregation (HP:0003540)2.27391920
77J-shaped sella turcica (HP:0002680)2.26541501
78Inappropriate behavior (HP:0000719)2.26367309
79Glomerulonephritis (HP:0000099)2.25599405
80Purpura (HP:0000979)2.24868187
81Iris hypopigmentation (HP:0007730)2.22727866
82Polyneuropathy (HP:0001271)2.22013695
83Recurrent pneumonia (HP:0006532)2.21507903
84Cutaneous melanoma (HP:0012056)2.19778174
85Arterial thrombosis (HP:0004420)2.18804922
86Keratitis (HP:0000491)2.18207437
87Gingival bleeding (HP:0000225)2.17406320
88Epistaxis (HP:0000421)2.16364820
89Congenital sensorineural hearing impairment (HP:0008527)2.15483998
90Episodic fever (HP:0001954)2.14998300
91Pulmonary infiltrates (HP:0002113)2.13758723
92Abnormal auditory evoked potentials (HP:0006958)2.13178635
93Hepatosplenomegaly (HP:0001433)2.12795616
94Facial diplegia (HP:0001349)2.11465877
95Hypochromic microcytic anemia (HP:0004840)2.09711737
96Encephalitis (HP:0002383)2.08633166
97Amyotrophic lateral sclerosis (HP:0007354)2.08606394
98Nausea (HP:0002018)2.07675107
99Eosinophilia (HP:0001880)2.07395610
100Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04143646
101Subacute progressive viral hepatitis (HP:0006572)2.04136207
102Dyschromatopsia (HP:0007641)2.01587135
103Keratoconjunctivitis sicca (HP:0001097)1.98917074
104Progressive neurologic deterioration (HP:0002344)1.98670553
105Atrophy/Degeneration involving motor neurons (HP:0007373)1.97864248
106Abnormality of the prostate (HP:0008775)1.97169941
107Neoplasm of head and neck (HP:0012288)1.94538642
108Esophageal neoplasm (HP:0100751)1.94538642
109Hemoptysis (HP:0002105)1.94114461
110Reduced antithrombin III activity (HP:0001976)1.93336027
111Hypergammaglobulinemia (HP:0010702)1.93042792
112Tetraparesis (HP:0002273)1.91900127
113Urticaria (HP:0001025)1.91408337
114Hypokinesia (HP:0002375)1.90970978
115Choroideremia (HP:0001139)1.88858236
116Blue irides (HP:0000635)1.88472929
117Patchy hypopigmentation of hair (HP:0011365)1.88328843
118White forelock (HP:0002211)1.86678500
119Recurrent lower respiratory tract infections (HP:0002783)1.86248299
120Recurrent bronchitis (HP:0002837)1.84371864
121Thick nail (HP:0001805)1.84139530
122Spondylolisthesis (HP:0003302)1.83519838
123Parakeratosis (HP:0001036)1.83507953
124Pathologic fracture (HP:0002756)1.82455479
125Thyroiditis (HP:0100646)1.80744445
126Poor head control (HP:0002421)1.80738356
127Abnormality of eosinophils (HP:0001879)1.80389113
128Degeneration of anterior horn cells (HP:0002398)1.79783156
129Abnormality of the anterior horn cell (HP:0006802)1.79783156
130Chronic mucocutaneous candidiasis (HP:0002728)1.78574964
131Recurrent cutaneous fungal infections (HP:0011370)1.78574964
132Metaphyseal dysplasia (HP:0100255)1.78408946
133Abnormality of the nasal mucosa (HP:0000433)1.78143936
134Thoracic kyphosis (HP:0002942)1.77145397
135Abnormal hair whorl (HP:0010721)1.76253500
136Osteolytic defects of the phalanges of the hand (HP:0009771)1.75593569
137Osteolytic defects of the hand bones (HP:0009699)1.75593569
138Leukocytosis (HP:0001974)1.75493240
139Cerebral hemorrhage (HP:0001342)1.75472982
140Anorexia (HP:0002039)1.74175742
141Cervical subluxation (HP:0003308)1.73988056
142Intrahepatic cholestasis (HP:0001406)1.73957244
143Abnormality of T cell physiology (HP:0011840)1.73408500
144Sepsis (HP:0100806)1.73304500
145Increased IgM level (HP:0003496)1.72349048
146Thoracolumbar scoliosis (HP:0002944)1.72130067
147Gangrene (HP:0100758)1.68950761
148Chest pain (HP:0100749)1.63047536
149Pulmonary embolism (HP:0002204)1.62258350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.03612309
2RIPK43.22085316
3MAP3K123.19844793
4BLK3.15620456
5KIT2.92748020
6TGFBR22.68867810
7MAP3K142.61370791
8TBK12.59757478
9IRAK42.37381828
10PDK22.34291110
11WNK32.32272342
12BCR2.32147259
13TXK2.26455147
14JAK32.22969621
15PIM22.18664645
16CAMKK22.14975513
17MAP4K12.12090053
18NME22.04026026
19TEC2.03654111
20ZAP701.96164647
21BTK1.90406039
22MATK1.82837582
23NEK91.81827325
24SYK1.80445316
25TYK21.77158057
26MST1R1.76814234
27IKBKE1.74436161
28FGR1.72185715
29TGFBR11.65163984
30MST41.62696561
31KDR1.51524383
32IKBKB1.46946232
33FER1.46070427
34WEE11.45395895
35TNIK1.39239219
36MAP2K31.38509354
37SCYL21.37768835
38IRAK31.36819987
39SIK31.36550731
40CSF1R1.34081789
41LYN1.33486753
42GRK71.31782799
43TIE11.31092089
44MAP4K21.29294904
45KSR11.29163916
46FES1.23749517
47MAPKAPK51.23471673
48ERBB31.22158604
49JAK11.18115409
50BMPR1B1.16997539
51LCK1.07731786
52IRAK21.05995245
53HCK1.04870284
54PBK1.04704514
55EPHA31.04331239
56NUAK11.03510341
57ERN11.03184563
58ACVR1B1.01730732
59MAP3K30.95988616
60PAK30.89663215
61MARK30.89369573
62PRKG20.89307039
63ADRBK20.89303400
64FGFR30.86579722
65TAOK30.86421562
66JAK20.84182337
67ITK0.82813688
68FLT30.82319703
69LRRK20.82149345
70MYLK0.81665991
71CSNK1G20.80823059
72CHUK0.79937654
73TRPM70.78394804
74PIM10.77383482
75MKNK20.77245252
76MAP3K110.76542408
77PRKCD0.75593724
78YES10.75204014
79BMPR20.74266235
80MKNK10.73644037
81MAP3K130.73478063
82PTK2B0.72571866
83CSK0.72413194
84DDR20.72187956
85ARAF0.70320552
86NEK10.69845544
87FRK0.66223794
88EIF2AK10.65885507
89TESK10.65430960
90STK160.64451781
91EPHB10.63896466
92MAP3K10.63357286
93DYRK30.62261862
94CSNK1G30.61067605
95CSNK1G10.60219540
96CDK60.58964777
97PLK30.58487924
98MAPK130.58251138
99ERBB40.58198600
100TNK20.57824376
101PINK10.57612856
102TAOK10.57318372
103MAP3K20.56696977
104CSNK1A1L0.56587587
105DAPK10.55718845
106STK30.54082128
107ROCK20.53032904
108RPS6KA40.51757229
109STK100.51563801
110CAMKK10.50740515
111ABL20.50155261
112BRSK20.49966966
113PDK10.49509571
114MAPKAPK20.48832822
115RPS6KA20.48220228
116LMTK20.46546814
117PRKCE0.45952240
118PAK40.45463162
119IGF1R0.44916401
120RPS6KA60.44082237
121CLK10.43452134
122EIF2AK30.42936570
123PIK3CG0.41890566
124MOS0.40840124
125EGFR0.40758739
126OXSR10.40636297
127ABL10.40615133
128NLK0.40337311
129PLK20.39416019
130ROCK10.38519651
131RAF10.38212877
132GRK50.37696921
133NEK60.37233207
134CDK80.36673004
135RPS6KC10.36041469
136RPS6KL10.36041469
137MAPK40.34901939
138IRAK10.34646199
139MAP3K50.34288881

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.90608414
2Lysosome_Homo sapiens_hsa041422.45953781
3Phagosome_Homo sapiens_hsa041452.40119697
4Other glycan degradation_Homo sapiens_hsa005112.34909766
5Rheumatoid arthritis_Homo sapiens_hsa053232.32065309
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.21855119
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.20361945
8Legionellosis_Homo sapiens_hsa051342.18999991
9Pertussis_Homo sapiens_hsa051332.18050354
10Osteoclast differentiation_Homo sapiens_hsa043802.15156136
11Tuberculosis_Homo sapiens_hsa051522.04604508
12Malaria_Homo sapiens_hsa051442.02627248
13Staphylococcus aureus infection_Homo sapiens_hsa051501.95325607
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86653903
15Steroid biosynthesis_Homo sapiens_hsa001001.82031399
16Salmonella infection_Homo sapiens_hsa051321.79132976
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75751943
18Hematopoietic cell lineage_Homo sapiens_hsa046401.73582427
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71708243
20Measles_Homo sapiens_hsa051621.71013991
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70634615
22Shigellosis_Homo sapiens_hsa051311.70358904
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.70154985
24Collecting duct acid secretion_Homo sapiens_hsa049661.69637395
25Graft-versus-host disease_Homo sapiens_hsa053321.65440553
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58440127
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55973058
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53362047
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52138987
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.51777118
31B cell receptor signaling pathway_Homo sapiens_hsa046621.49783126
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49394853
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48563193
34Vibrio cholerae infection_Homo sapiens_hsa051101.40520565
35Propanoate metabolism_Homo sapiens_hsa006401.39332654
36Allograft rejection_Homo sapiens_hsa053301.38573418
37Antigen processing and presentation_Homo sapiens_hsa046121.38060781
38TNF signaling pathway_Homo sapiens_hsa046681.33028338
39Toxoplasmosis_Homo sapiens_hsa051451.32734252
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31889286
41Fatty acid elongation_Homo sapiens_hsa000621.30082347
42Influenza A_Homo sapiens_hsa051641.29408218
43Glutathione metabolism_Homo sapiens_hsa004801.27977784
44Asthma_Homo sapiens_hsa053101.27468852
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.24293306
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23457729
47African trypanosomiasis_Homo sapiens_hsa051431.18693702
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17189882
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13358105
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13183437
51Apoptosis_Homo sapiens_hsa042101.13032919
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11746731
53Hepatitis B_Homo sapiens_hsa051611.11575872
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09628805
55Platelet activation_Homo sapiens_hsa046111.08971391
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.08526310
57Type I diabetes mellitus_Homo sapiens_hsa049401.08392320
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.07596142
59Chemokine signaling pathway_Homo sapiens_hsa040621.07577350
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07159735
61Protein export_Homo sapiens_hsa030601.05080909
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03951209
63Complement and coagulation cascades_Homo sapiens_hsa046100.96390469
64Primary immunodeficiency_Homo sapiens_hsa053400.93626935
65Proteasome_Homo sapiens_hsa030500.93552401
66Herpes simplex infection_Homo sapiens_hsa051680.92324712
67Caffeine metabolism_Homo sapiens_hsa002320.90771267
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88122706
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87411327
70Renin-angiotensin system_Homo sapiens_hsa046140.84261006
71Hepatitis C_Homo sapiens_hsa051600.82759101
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.80568871
73Viral myocarditis_Homo sapiens_hsa054160.75951814
74PPAR signaling pathway_Homo sapiens_hsa033200.75699084
75Acute myeloid leukemia_Homo sapiens_hsa052210.74063129
76N-Glycan biosynthesis_Homo sapiens_hsa005100.70950729
77Fatty acid metabolism_Homo sapiens_hsa012120.69843789
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67355917
79Prolactin signaling pathway_Homo sapiens_hsa049170.66670961
80Pancreatic cancer_Homo sapiens_hsa052120.65912359
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.65866020
82T cell receptor signaling pathway_Homo sapiens_hsa046600.65846206
83Peroxisome_Homo sapiens_hsa041460.65369962
84Synaptic vesicle cycle_Homo sapiens_hsa047210.65273114
85Amoebiasis_Homo sapiens_hsa051460.65165110
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64269758
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63382543
88Sphingolipid metabolism_Homo sapiens_hsa006000.61993743
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59601324
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59548705
91Dorso-ventral axis formation_Homo sapiens_hsa043200.59465824
92Non-homologous end-joining_Homo sapiens_hsa034500.58041711
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57608685
94Chronic myeloid leukemia_Homo sapiens_hsa052200.56411826
95Autoimmune thyroid disease_Homo sapiens_hsa053200.56162212
96Endocytosis_Homo sapiens_hsa041440.55802036
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53010023
98Fatty acid degradation_Homo sapiens_hsa000710.52348799
99Epstein-Barr virus infection_Homo sapiens_hsa051690.51615296
100Nitrogen metabolism_Homo sapiens_hsa009100.49527639
101p53 signaling pathway_Homo sapiens_hsa041150.47246095
102Sulfur metabolism_Homo sapiens_hsa009200.47202752
103HIF-1 signaling pathway_Homo sapiens_hsa040660.45655904
104Thyroid cancer_Homo sapiens_hsa052160.42785751
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41919024
106Viral carcinogenesis_Homo sapiens_hsa052030.40245243
107VEGF signaling pathway_Homo sapiens_hsa043700.36136181
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34905899
109Mineral absorption_Homo sapiens_hsa049780.34768573
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34486577
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34279502
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32565030
113Basal transcription factors_Homo sapiens_hsa030220.31052692
114Galactose metabolism_Homo sapiens_hsa000520.29647760
115Proteoglycans in cancer_Homo sapiens_hsa052050.29028049
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28105459
117Prion diseases_Homo sapiens_hsa050200.27648778
118Focal adhesion_Homo sapiens_hsa045100.25188480
119Butanoate metabolism_Homo sapiens_hsa006500.24875848
120Regulation of autophagy_Homo sapiens_hsa041400.24378033
121Non-small cell lung cancer_Homo sapiens_hsa052230.24297739
122Rap1 signaling pathway_Homo sapiens_hsa040150.23817281
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23009684
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22778444
125Arachidonic acid metabolism_Homo sapiens_hsa005900.22011608

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