SDCBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.53588087
2angiotensin maturation (GO:0002003)7.25446067
3pyrimidine-containing compound transmembrane transport (GO:0072531)7.10442024
4bundle of His cell to Purkinje myocyte communication (GO:0086069)6.37120269
5vitamin transmembrane transport (GO:0035461)6.11232940
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.05104077
7rRNA catabolic process (GO:0016075)5.98833556
8positive regulation of prostaglandin secretion (GO:0032308)5.75249482
9keratinization (GO:0031424)5.58907115
10purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.31847238
113-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.31847238
12carnitine shuttle (GO:0006853)5.27450151
13NADH metabolic process (GO:0006734)5.25666318
14negative regulation of cholesterol transport (GO:0032375)5.05391695
15negative regulation of sterol transport (GO:0032372)5.05391695
16flavonoid metabolic process (GO:0009812)5.04184814
17regulation of prostaglandin secretion (GO:0032306)4.91636140
18intestinal absorption (GO:0050892)4.90058270
19maintenance of gastrointestinal epithelium (GO:0030277)4.84587809
20epoxygenase P450 pathway (GO:0019373)4.81947729
21bile acid and bile salt transport (GO:0015721)4.81285143
22antimicrobial humoral response (GO:0019730)4.75671308
23fat-soluble vitamin biosynthetic process (GO:0042362)4.65940159
24antibacterial humoral response (GO:0019731)4.54094808
25intestinal epithelial cell development (GO:0060576)4.47619627
26histone-serine phosphorylation (GO:0035404)4.46946925
27hepatocyte apoptotic process (GO:0097284)4.43549035
28fatty acid homeostasis (GO:0055089)4.43292142
29phosphatidylserine acyl-chain remodeling (GO:0036150)4.41017934
30calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.40064138
31regulation of energy homeostasis (GO:2000505)4.38213154
32regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.36808424
33endocrine process (GO:0050886)4.36808424
34regulation of systemic arterial blood pressure by hormone (GO:0001990)4.36808424
35actin filament depolymerization (GO:0030042)4.27913997
36fatty acid transmembrane transport (GO:1902001)4.24752006
37sulfur amino acid catabolic process (GO:0000098)4.23195831
38lipoprotein transport (GO:0042953)4.19142602
39positive regulation of icosanoid secretion (GO:0032305)4.17196333
40cellular glucuronidation (GO:0052695)4.17131759
41regulation of bile acid biosynthetic process (GO:0070857)4.16390910
42hemidesmosome assembly (GO:0031581)4.15617182
43UDP-N-acetylglucosamine metabolic process (GO:0006047)4.14137274
44renal system process involved in regulation of blood volume (GO:0001977)4.12185877
45positive regulation of macrophage derived foam cell differentiation (GO:0010744)4.11235036
46regulation of water loss via skin (GO:0033561)4.08654499
47urea cycle (GO:0000050)4.06744912
48regulation of cellular extravasation (GO:0002691)4.05411418
49positive regulation of respiratory burst (GO:0060267)4.04528832
50carnitine transmembrane transport (GO:1902603)4.04253417
51positive regulation of glycolytic process (GO:0045821)4.01959969
52sulfate transmembrane transport (GO:1902358)3.97960094
53receptor guanylyl cyclase signaling pathway (GO:0007168)3.97827637
54epithelial structure maintenance (GO:0010669)3.93601061
55fructose metabolic process (GO:0006000)3.92860198
56phosphatidylinositol acyl-chain remodeling (GO:0036149)3.92639292
57regulation of systemic arterial blood pressure (GO:0003073)3.92597400
58urea metabolic process (GO:0019627)3.91013448
59phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.85745084
60drug metabolic process (GO:0017144)3.82827891
61regulation of guanylate cyclase activity (GO:0031282)3.81969929
62regulation of cholesterol efflux (GO:0010874)3.78961049
63establishment of skin barrier (GO:0061436)3.78289665
64phospholipid efflux (GO:0033700)3.77428984
65amino-acid betaine transport (GO:0015838)3.75992253
66carnitine transport (GO:0015879)3.75992253
67regulation of triglyceride catabolic process (GO:0010896)3.74658367
68diacylglycerol metabolic process (GO:0046339)3.67984909
69positive regulation of guanylate cyclase activity (GO:0031284)3.66583503
70regulation of T cell tolerance induction (GO:0002664)3.65269248
71glomerular filtration (GO:0003094)3.64986010
72phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.62762833
73galactose catabolic process (GO:0019388)3.61573056
74sulfur compound transport (GO:0072348)3.60371992
75glucuronate metabolic process (GO:0019585)3.60353299
76uronic acid metabolic process (GO:0006063)3.60353299
77nitrogen cycle metabolic process (GO:0071941)3.59911218
78hormone catabolic process (GO:0042447)3.59340337
79regulation of cholesterol homeostasis (GO:2000188)3.59054118
80positive regulation of pseudopodium assembly (GO:0031274)3.54379518
81very-low-density lipoprotein particle assembly (GO:0034379)3.49600316
82renal filtration (GO:0097205)3.47791836
83nucleoside diphosphate biosynthetic process (GO:0009133)3.43556310
84phosphatidylserine metabolic process (GO:0006658)3.41538810
85positive regulation of fatty acid transport (GO:2000193)3.40731666
86hypotonic response (GO:0006971)3.40443175
87cellular response to glucose starvation (GO:0042149)3.36934911
88regulation of cGMP biosynthetic process (GO:0030826)3.35771567
89water homeostasis (GO:0030104)3.35622948
90negative regulation of keratinocyte proliferation (GO:0010839)3.31792136
91macrophage chemotaxis (GO:0048246)3.29090542
92digestion (GO:0007586)3.28340035
93regulation of transforming growth factor beta1 production (GO:0032908)3.27879454
94positive regulation of Cdc42 GTPase activity (GO:0043089)3.27783008
95oligosaccharide biosynthetic process (GO:0009312)3.26752206
96sulfation (GO:0051923)3.24571493
97positive regulation of cGMP biosynthetic process (GO:0030828)3.24003177
98peptide catabolic process (GO:0043171)3.21650975
99sulfate transport (GO:0008272)3.21030167
100intermediate filament organization (GO:0045109)3.19979921
101plasma lipoprotein particle assembly (GO:0034377)3.18636364
102fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.12478774
103phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.12255060
104virion attachment to host cell (GO:0019062)3.11727185
105adhesion of symbiont to host cell (GO:0044650)3.11727185
106ethanol oxidation (GO:0006069)3.10962796
107glycolipid catabolic process (GO:0019377)3.10498428
108bicarbonate transport (GO:0015701)3.10410319
109nucleotide-sugar biosynthetic process (GO:0009226)3.10107427
110regulation of cholesterol transport (GO:0032374)3.08274008
111regulation of sterol transport (GO:0032371)3.08274008
112arginine metabolic process (GO:0006525)3.07328747
113vitamin A metabolic process (GO:0006776)3.06876284
114GDP-mannose metabolic process (GO:0019673)3.06639654
115regulation of pseudopodium assembly (GO:0031272)3.05782638
116positive regulation of lipid catabolic process (GO:0050996)3.05063319
117regulation of macrophage derived foam cell differentiation (GO:0010743)3.04598791
118glycosphingolipid catabolic process (GO:0046479)3.04191232
119cGMP-mediated signaling (GO:0019934)3.01405620
120protein-lipid complex assembly (GO:0065005)3.01184446
121digestive system process (GO:0022600)3.01101800
122transcytosis (GO:0045056)2.99694282
123positive regulation of lipid storage (GO:0010884)2.99308336
124morphogenesis of an epithelial fold (GO:0060571)2.97952702
125renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.95497537
126auditory receptor cell differentiation (GO:0042491)2.94979464
127regulation of icosanoid secretion (GO:0032303)2.94613672
128peptide hormone processing (GO:0016486)2.93106183
129positive regulation of glycoprotein metabolic process (GO:1903020)2.92687410
130intracellular lipid transport (GO:0032365)2.92224384
131respiratory tube development (GO:0030323)2.91558693
132alditol phosphate metabolic process (GO:0052646)2.90021900
133regulation of cholesterol esterification (GO:0010872)2.88991866
134sphingomyelin metabolic process (GO:0006684)2.88986685
135epithelial cell-cell adhesion (GO:0090136)2.88426939
136positive regulation of triglyceride lipase activity (GO:0061365)2.88162099
137positive regulation of lipoprotein lipase activity (GO:0051006)2.88162099
138glutamine family amino acid biosynthetic process (GO:0009084)2.84602805
139positive regulation of interleukin-1 secretion (GO:0050716)2.83475231
140cyclooxygenase pathway (GO:0019371)2.82171672
141lipoprotein metabolic process (GO:0042157)2.82024836
142phosphatidylcholine acyl-chain remodeling (GO:0036151)2.80305476
143phosphatidylcholine biosynthetic process (GO:0006656)2.79325064
144drug catabolic process (GO:0042737)2.77938492
145regulation of interleukin-1 secretion (GO:0050704)2.77747538
146sodium ion homeostasis (GO:0055078)2.77471130
147positive regulation of epidermal cell differentiation (GO:0045606)2.76674819
148regulation of vitamin metabolic process (GO:0030656)2.76087532
149O-glycan processing (GO:0016266)2.75571879
150positive regulation of cGMP metabolic process (GO:0030825)2.74635825
151alkaloid metabolic process (GO:0009820)2.74109125
152tumor necrosis factor-mediated signaling pathway (GO:0033209)2.73874810
153glycosylceramide metabolic process (GO:0006677)2.73854640
154intestinal cholesterol absorption (GO:0030299)2.72782726
155ventricular septum development (GO:0003281)2.71971954
156multicellular organismal water homeostasis (GO:0050891)2.71778153
157regulation of cGMP metabolic process (GO:0030823)2.69693754
158positive regulation of tolerance induction (GO:0002645)2.69550345
159regulation of cholesterol metabolic process (GO:0090181)2.66594478
160regulation of respiratory burst (GO:0060263)2.66541914
161positive regulation of glycoprotein biosynthetic process (GO:0010560)2.66535954
162regulation of proton transport (GO:0010155)2.64883932
163phosphatidylcholine metabolic process (GO:0046470)2.64825150
164phospholipid transport (GO:0015914)2.63996886
165positive regulation of T cell differentiation in thymus (GO:0033089)2.61363346
166negative regulation of protein oligomerization (GO:0032460)2.60987558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.96789316
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.99806954
3SRY_22984422_ChIP-ChIP_TESTIS_Rat3.34414589
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.24274846
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.22661123
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.17129833
7* SOX2_20726797_ChIP-Seq_SW620_Human2.85489055
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.74263471
9GATA6_25053715_ChIP-Seq_YYC3_Human2.55427454
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45572361
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.44799227
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.35624927
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.27422968
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25008190
15GATA4_25053715_ChIP-Seq_YYC3_Human2.22202620
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.07287865
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.00760345
18RACK7_27058665_Chip-Seq_MCF-7_Human1.99144102
19PPARA_22158963_ChIP-Seq_LIVER_Mouse1.93180633
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.91766966
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.90070056
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86875104
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85201850
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81178674
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76785436
26ATF3_27146783_Chip-Seq_COLON_Human1.74965564
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74901271
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.74643654
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.69931557
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67434530
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64343330
32ZNF263_19887448_ChIP-Seq_K562_Human1.63519422
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62644560
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62010251
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62010251
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58941253
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.55259415
38KLF5_25053715_ChIP-Seq_YYC3_Human1.55162587
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53091385
40P63_26484246_Chip-Seq_KERATINOCYTES_Human1.52724987
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.52005110
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47599623
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46818808
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45837592
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.45626514
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.43170299
47FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37267413
48BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.37210396
49* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36936582
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33616548
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.24639800
52OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22773898
53* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22751035
54* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22647497
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.20886679
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18517768
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.15693803
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.15638890
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15093163
60* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14883544
61* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12307134
62LXR_22292898_ChIP-Seq_THP-1_Human1.10090035
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09160093
64JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.08585025
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07280254
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06572121
67* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06398563
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06099301
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04471544
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04144226
71TCF4_18268006_ChIP-ChIP_LS174T_Human1.03721732
72FOXA1_25552417_ChIP-Seq_VCAP_Human1.02376186
73* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00434444
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00178093
75TP63_22573176_ChIP-Seq_HFKS_Human1.00009783
76DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98311257
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98202964
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97551675
79CLOCK_20551151_ChIP-Seq_293T_Human0.97512803
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96886441
81* TET1_21451524_ChIP-Seq_MESCs_Mouse0.96153092
82NANOG_20526341_ChIP-Seq_ESCs_Human0.95765381
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95070485
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94490058
85SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93634768
86CEBPB_22108803_ChIP-Seq_LS180_Human0.93116668
87* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92608832
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92551359
89* CREB1_26743006_Chip-Seq_LNCaP_Human0.92374486
90TP63_23658742_ChIP-Seq_EP156T_Human0.92264093
91CTCF_20526341_ChIP-Seq_ESCs_Human0.92069317
92* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91716419
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91607433
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91279753
95E2F1_20622854_ChIP-Seq_HELA_Human0.90810923
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90664460
97BCL6_27268052_Chip-Seq_Bcells_Human0.90500123
98* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89192966
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88936502
100ERG_21242973_ChIP-ChIP_JURKAT_Human0.88670208
101RXR_22108803_ChIP-Seq_LS180_Human0.88415470
102EGR1_19032775_ChIP-ChIP_M12_Human0.87658534
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.86843786
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.86438792
105* HNF4A_19822575_ChIP-Seq_HepG2_Human0.86238531
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85639527
107NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85394079
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85348123
109* ELK3_25401928_ChIP-Seq_HUVEC_Human0.84777505
110GATA1_19941826_ChIP-Seq_K562_Human0.84601589
111SA1_27219007_Chip-Seq_Bcells_Human0.83323853
112* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83006391
113SMAD_19615063_ChIP-ChIP_OVARY_Human0.82588200
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81997019
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81965645
116CTCF_27219007_Chip-Seq_Bcells_Human0.81587957
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81106862
118BCOR_27268052_Chip-Seq_Bcells_Human0.80303491
119GATA2_19941826_ChIP-Seq_K562_Human0.80242331
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80220109
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80141345
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79705211
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79596177
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79596177
125* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78979419
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78617991
127SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77853743
128MYC_19915707_ChIP-ChIP_AK7_Human0.77422523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle8.59255850
2MP0002822_catalepsy4.65887770
3MP0003878_abnormal_ear_physiology4.28217158
4MP0005377_hearing/vestibular/ear_phenot4.28217158
5MP0001873_stomach_inflammation3.37989312
6MP0009379_abnormal_foot_pigmentation3.17974313
7MP0003866_abnormal_defecation3.14226130
8MP0004264_abnormal_extraembryonic_tissu3.12430449
9MP0005365_abnormal_bile_salt2.84410481
10MP0003283_abnormal_digestive_organ2.77056312
11MP0000462_abnormal_digestive_system2.71083828
12MP0003183_abnormal_peptide_metabolism2.68596271
13MP0002796_impaired_skin_barrier2.68586428
14MP0000537_abnormal_urethra_morphology2.45404286
15MP0010155_abnormal_intestine_physiology2.34557122
16MP0001666_abnormal_nutrient_absorption2.29832776
17MP0003941_abnormal_skin_development2.29764428
18MP0005409_darkened_coat_color2.22725195
19MP0005167_abnormal_blood-brain_barrier2.16442718
20MP0001663_abnormal_digestive_system2.13072090
21MP0005381_digestive/alimentary_phenotyp2.06576628
22MP0010352_gastrointestinal_tract_polyps2.04053673
23MP0001664_abnormal_digestion2.03821510
24MP0002909_abnormal_adrenal_gland2.01601470
25MP0004147_increased_porphyrin_level1.98936683
26MP0000516_abnormal_urinary_system1.97081198
27MP0005367_renal/urinary_system_phenotyp1.97081198
28MP0005257_abnormal_intraocular_pressure1.96867469
29MP0000477_abnormal_intestine_morphology1.89038220
30MP0010678_abnormal_skin_adnexa1.86514865
31MP0003315_abnormal_perineum_morphology1.81739663
32MP0004947_skin_inflammation1.72995737
33MP0003453_abnormal_keratinocyte_physiol1.72217598
34MP0008875_abnormal_xenobiotic_pharmacok1.70474108
35MP0000579_abnormal_nail_morphology1.70383901
36MP0000490_abnormal_crypts_of1.69180534
37MP0008004_abnormal_stomach_pH1.65183404
38MP0003300_gastrointestinal_ulcer1.60783341
39MP0005501_abnormal_skin_physiology1.60644258
40MP0003191_abnormal_cellular_cholesterol1.60381942
41MP0010329_abnormal_lipoprotein_level1.57327195
42MP0001216_abnormal_epidermal_layer1.52614599
43MP0009785_altered_susceptibility_to1.49503665
44MP0003705_abnormal_hypodermis_morpholog1.45351953
45MP0005085_abnormal_gallbladder_physiolo1.43800530
46MP0005360_urolithiasis1.42515892
47MP0002876_abnormal_thyroid_physiology1.36430821
48MP0002060_abnormal_skin_morphology1.36023195
49MP0005332_abnormal_amino_acid1.35561888
50MP0004130_abnormal_muscle_cell1.31180159
51MP0000566_synostosis1.30493119
52MP0005451_abnormal_body_composition1.29119539
53MP0005076_abnormal_cell_differentiation1.28386445
54MP0000538_abnormal_urinary_bladder1.25843134
55MP0001188_hyperpigmentation1.25609790
56MP0009780_abnormal_chondrocyte_physiolo1.24684739
57MP0000383_abnormal_hair_follicle1.24673194
58MP0002136_abnormal_kidney_physiology1.17365888
59MP0002132_abnormal_respiratory_system1.17074329
60MP0002098_abnormal_vibrissa_morphology1.16692837
61MP0000013_abnormal_adipose_tissue1.16448486
62MP0005670_abnormal_white_adipose1.14931879
63MP0001849_ear_inflammation1.12003444
64MP0000470_abnormal_stomach_morphology1.10156424
65MP0009643_abnormal_urine_homeostasis1.08683564
66MP0004185_abnormal_adipocyte_glucose1.04368635
67MP0003252_abnormal_bile_duct1.04053658
68MP0001765_abnormal_ion_homeostasis1.02274646
69MP0003303_peritoneal_inflammation1.00827318
70MP0004858_abnormal_nervous_system0.99660167
71MP0004043_abnormal_pH_regulation0.98109203
72MP0000685_abnormal_immune_system0.97961968
73MP0010771_integument_phenotype0.97463788
74MP0001756_abnormal_urination0.97211511
75MP0000467_abnormal_esophagus_morphology0.96439002
76MP0004782_abnormal_surfactant_physiolog0.95900646
77MP0001764_abnormal_homeostasis0.94973157
78MP0005671_abnormal_response_to0.90793979
79MP0004270_analgesia0.89565017
80MP0005275_abnormal_skin_tensile0.89336485
81MP0004484_altered_response_of0.87370291
82MP0005166_decreased_susceptibility_to0.85149012
83MP0003806_abnormal_nucleotide_metabolis0.83686801
84MP0005666_abnormal_adipose_tissue0.82110175
85MP0000678_abnormal_parathyroid_gland0.81176355
86MP0004019_abnormal_vitamin_homeostasis0.79806447
87MP0003879_abnormal_hair_cell0.78493998
88MP0005058_abnormal_lysosome_morphology0.77084891
89MP0005636_abnormal_mineral_homeostasis0.76149455
90MP0005023_abnormal_wound_healing0.75976650
91MP0000230_abnormal_systemic_arterial0.75717490
92MP0000609_abnormal_liver_physiology0.75509183
93MP0002971_abnormal_brown_adipose0.74499045
94MP0005584_abnormal_enzyme/coenzyme_acti0.73164067
95MP0000377_abnormal_hair_follicle0.72997203
96MP0002148_abnormal_hypersensitivity_rea0.72902743
97MP0001845_abnormal_inflammatory_respons0.71058244
98MP0005025_abnormal_response_to0.70962141
99MP0003724_increased_susceptibility_to0.69888531
100MP0001501_abnormal_sleep_pattern0.69417462
101MP0002139_abnormal_hepatobiliary_system0.69246809
102MP0005448_abnormal_energy_balance0.68757898
103MP0002166_altered_tumor_susceptibility0.68579059
104MP0003329_amyloid_beta_deposits0.68156148
105MP0009384_cardiac_valve_regurgitation0.67526015
106MP0002234_abnormal_pharynx_morphology0.67091794
107MP0001485_abnormal_pinna_reflex0.66852612
108MP0000465_gastrointestinal_hemorrhage0.66784628
109MP0002138_abnormal_hepatobiliary_system0.66444764
110MP0003950_abnormal_plasma_membrane0.65036420
111MP0005266_abnormal_metabolism0.64539264
112MP0008260_abnormal_autophagy0.64080055
113MP0005165_increased_susceptibility_to0.63235149
114MP0005310_abnormal_salivary_gland0.63078211
115MP0005319_abnormal_enzyme/_coenzyme0.62690027
116MP0006082_CNS_inflammation0.61779656
117MP0000367_abnormal_coat/_hair0.60211878
118MP0000613_abnormal_salivary_gland0.59907846
119MP0003868_abnormal_feces_composition0.59357041
120MP0002006_tumorigenesis0.58977250
121MP0002118_abnormal_lipid_homeostasis0.58820781
122MP0009840_abnormal_foam_cell0.57230282
123MP0003638_abnormal_response/metabolism_0.57066426
124MP0000249_abnormal_blood_vessel0.56357229
125MP0005187_abnormal_penis_morphology0.55705828
126MP0008872_abnormal_physiological_respon0.55532272
127MP0005535_abnormal_body_temperature0.55307652
128MP0008873_increased_physiological_sensi0.53399524
129MP0009115_abnormal_fat_cell0.53180703
130MP0002896_abnormal_bone_mineralization0.52591990
131MP0001191_abnormal_skin_condition0.52335173
132MP0000343_altered_response_to0.51887179
133MP0001800_abnormal_humoral_immune0.51222952
134MP0009931_abnormal_skin_appearance0.50015010
135MP0000762_abnormal_tongue_morphology0.49523617
136MP0003566_abnormal_cell_adhesion0.48126528

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.45097407
2Right ventricular cardiomyopathy (HP:0011663)5.98073781
3Abnormal tarsal ossification (HP:0008369)5.90838787
4Flat acetabular roof (HP:0003180)5.67996999
5Abnormality of small intestinal villus morphology (HP:0011472)5.44443647
6Villous atrophy (HP:0011473)5.44443647
7Abnormality of the 1st metacarpal (HP:0010009)5.35605922
8Hydroxyprolinuria (HP:0003080)5.13517989
9Abnormality of proline metabolism (HP:0010907)5.13517989
10Pustule (HP:0200039)4.96670840
11Malnutrition (HP:0004395)4.37011101
12Metabolic alkalosis (HP:0200114)4.34798166
13Abnormal foot bone ossification (HP:0010675)4.32670855
14Cupped ribs (HP:0000887)4.22181098
15Abnormality of carpal bone ossification (HP:0006257)4.13538480
16Abdominal distention (HP:0003270)4.00353214
17Abnormality of monocarboxylic acid metabolism (HP:0010996)3.84590334
18Septate vagina (HP:0001153)3.78561118
19Woolly hair (HP:0002224)3.75730372
20Hyperactive renin-angiotensin system (HP:0000841)3.73781542
21Ileus (HP:0002595)3.73688683
22Short phalanx of the thumb (HP:0009660)3.70092593
23Fat malabsorption (HP:0002630)3.66079729
24Short 1st metacarpal (HP:0010034)3.51621840
25Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.51621840
26Abnormality of the 2nd finger (HP:0004100)3.48427365
27Fragile nails (HP:0001808)3.47349960
28Hypobetalipoproteinemia (HP:0003563)3.46670449
29Abnormality of the vitamin B12 metabolism (HP:0004341)3.45116147
30Systemic lupus erythematosus (HP:0002725)3.39245509
31Ureteral stenosis (HP:0000071)3.36904898
32Chronic diarrhea (HP:0002028)3.22206337
33Increased IgE level (HP:0003212)3.21815070
34Abnormality of vitamin B metabolism (HP:0004340)3.18792824
35Confusion (HP:0001289)3.17246209
36Ureteral obstruction (HP:0006000)3.14153140
37Abnormal ossification of hand bones (HP:0005921)3.13809067
38Abnormal hand bone ossification (HP:0010660)3.06816334
39Abnormality of the distal phalanx of the thumb (HP:0009617)3.06422448
40Plantar hyperkeratosis (HP:0007556)3.02433843
41Milia (HP:0001056)2.96575626
42Prostate neoplasm (HP:0100787)2.93463591
43Acanthocytosis (HP:0001927)2.90978492
44Decreased circulating renin level (HP:0003351)2.89654425
45Abnormality of renin-angiotensin system (HP:0000847)2.85584212
46Abnormality of vitamin metabolism (HP:0100508)2.85250094
47Congenital sensorineural hearing impairment (HP:0008527)2.82624973
48Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.81227744
49Abnormal hair laboratory examination (HP:0003328)2.80582561
50Eczematoid dermatitis (HP:0000976)2.76364281
51Petechiae (HP:0000967)2.70536611
52Hemorrhage of the eye (HP:0011885)2.70096275
53Symphalangism affecting the phalanges of the hand (HP:0009773)2.69153719
54Abnormality of chloride homeostasis (HP:0011422)2.67916179
55Short hallux (HP:0010109)2.58612456
56Congenital ichthyosiform erythroderma (HP:0007431)2.58084506
57Xanthomatosis (HP:0000991)2.56054451
58Alopecia of scalp (HP:0002293)2.55562765
59Cheilitis (HP:0100825)2.54323254
60Atrophic scars (HP:0001075)2.50829697
61Irregular epiphyses (HP:0010582)2.50240391
62Dehydration (HP:0001944)2.49422936
63Nausea (HP:0002018)2.47066259
64Onycholysis (HP:0001806)2.45166673
65Abnormality of nail color (HP:0100643)2.45081664
66Thick nail (HP:0001805)2.43518003
67Micronodular cirrhosis (HP:0001413)2.43086846
68Proximal tubulopathy (HP:0000114)2.38935285
69Steatorrhea (HP:0002570)2.38784102
70Erythema (HP:0010783)2.36795036
71Flattened epiphyses (HP:0003071)2.35845647
72Oligomenorrhea (HP:0000876)2.35527580
73Aplasia/Hypoplasia of the hallux (HP:0008362)2.35051774
74Ventricular tachycardia (HP:0004756)2.33905108
75Hyperammonemia (HP:0001987)2.31944541
76Nephrolithiasis (HP:0000787)2.30275268
77Abnormality of urine glucose concentration (HP:0011016)2.30265720
78Glycosuria (HP:0003076)2.30265720
79Intrahepatic cholestasis (HP:0001406)2.30178751
80Oral leukoplakia (HP:0002745)2.30019604
81Wide cranial sutures (HP:0010537)2.29032560
82Neonatal short-limb short stature (HP:0008921)2.29009258
83Short middle phalanx of finger (HP:0005819)2.28075780
84Palmar hyperkeratosis (HP:0010765)2.27259422
85Flat capital femoral epiphysis (HP:0003370)2.26704092
86Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.25569601
87Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.25014583
88Vertebral hypoplasia (HP:0008417)2.25014583
89Palpitations (HP:0001962)2.24334128
90Hyperglycinuria (HP:0003108)2.23723657
91Conjugated hyperbilirubinemia (HP:0002908)2.22252218
92Pigmentary retinal degeneration (HP:0001146)2.20638715
93Abnormality of the proximal phalanges of the hand (HP:0009834)2.19296827
94Spontaneous abortion (HP:0005268)2.18607155
95Palmoplantar hyperkeratosis (HP:0000972)2.18104984
96Hypotension (HP:0002615)2.17535051
97Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16662483
98Abnormal vertebral ossification (HP:0100569)2.15668444
99Increased purine levels (HP:0004368)2.15341227
100Hyperuricemia (HP:0002149)2.15341227
101Hyponatremia (HP:0002902)2.11072248
102Gastrointestinal dysmotility (HP:0002579)2.10418826
103Breech presentation (HP:0001623)2.10304019
104Alkalosis (HP:0001948)2.09691423
105Abnormality of the costochondral junction (HP:0000919)2.08123255
106Parakeratosis (HP:0001036)2.07440400
107Vertebral clefting (HP:0008428)2.06276100
108Hypokalemia (HP:0002900)2.06172157
109Hypophosphatemia (HP:0002148)2.05679815
110Proximal placement of thumb (HP:0009623)2.05669432
111Epidermoid cyst (HP:0200040)2.05617348
112Biliary tract neoplasm (HP:0100574)2.04549284
113Abnormality of serine family amino acid metabolism (HP:0010894)2.01469228
114Abnormality of glycine metabolism (HP:0010895)2.01469228
115Deviation of the thumb (HP:0009603)2.01218231
116Pili torti (HP:0003777)2.00493214
117Hyperparathyroidism (HP:0000843)2.00041218
118Abnormal biliary tract morphology (HP:0012440)1.98710924
119Abnormality of purine metabolism (HP:0004352)1.98475185
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97832225
121Dicarboxylic aciduria (HP:0003215)1.97832225
122Hyperphosphatemia (HP:0002905)1.96518096
123Hypotrichosis (HP:0001006)1.96062566
124Hypolipoproteinemia (HP:0010981)1.94776279
125Vacuolated lymphocytes (HP:0001922)1.94493949
126Glomerulosclerosis (HP:0000096)1.92719582
127Posterior subcapsular cataract (HP:0007787)1.91544450
128Renal tubular acidosis (HP:0001947)1.91421192
129Axonal loss (HP:0003447)1.91284797
130Genu varum (HP:0002970)1.90831809
131Enlarged epiphyses (HP:0010580)1.90401185
132Abnormal cartilage morphology (HP:0002763)1.90365518
133Abnormality of nucleobase metabolism (HP:0010932)1.89508516
134Abnormality of potassium homeostasis (HP:0011042)1.88684086
135Hypoglycemic coma (HP:0001325)1.86625721
136Aplasia/hypoplasia of the femur (HP:0005613)1.85749750
137Corneal erosion (HP:0200020)1.85749685
138Syncope (HP:0001279)1.85335204
139Growth hormone excess (HP:0000845)1.83929983
140Vascular calcification (HP:0004934)1.83515409
141Segmental peripheral demyelination/remyelination (HP:0003481)1.82753081
142Hoarse voice (HP:0001609)1.81503467
143Thin bony cortex (HP:0002753)1.80546515
144Abnormal blistering of the skin (HP:0008066)1.80021435
145Metaphyseal irregularity (HP:0003025)1.79662433
146Pterygium (HP:0001059)1.78112177
147Abnormality of the phalanges of the hallux (HP:0010057)1.77413654
148Abnormality of T cell physiology (HP:0011840)1.77056290
149Focal segmental glomerulosclerosis (HP:0000097)1.76177233
150Widely patent fontanelles and sutures (HP:0004492)1.76049847
151Esophageal varix (HP:0002040)1.75240113
152Abnormality of the distal phalanges of the toes (HP:0010182)1.71889128
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68762264
154Symptomatic seizures (HP:0011145)1.68613086
155Protuberant abdomen (HP:0001538)1.65146531
156Inflammation of the large intestine (HP:0002037)1.64885912
157Nail dystrophy (HP:0008404)1.64556305
158Curly hair (HP:0002212)1.63146907
159Hyperaldosteronism (HP:0000859)1.62011317

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R9.65514963
2PIK3CA5.71876556
3ACVR1B5.06807354
4ERN13.56633148
5MAP3K23.52971623
6MET3.51979121
7MST43.29549450
8MAP2K23.14131755
9FRK2.92039644
10KSR22.76830712
11EPHA22.34187503
12NME12.22076142
13MAP3K72.20259795
14EPHB22.18651343
15LMTK21.78208055
16TESK11.76796430
17ARAF1.57998546
18STK391.53078640
19MYLK1.49311202
20MAP2K11.47490007
21PIM21.46320633
22PRKG21.33206913
23CAMKK21.25315355
24PTK61.21610860
25PRPF4B1.19110800
26CAMK2D1.09037131
27TBK11.08226140
28STK111.05120460
29TAOK11.02745150
30MAP3K121.01200501
31PDK21.00591093
32OXSR10.92480001
33MAP3K10.91674984
34RPS6KB20.88132372
35IKBKE0.83558239
36MAP3K140.82283456
37EPHA40.78855428
38GRK60.78543542
39ERBB40.75441196
40TAOK30.75388750
41MATK0.75116916
42MAP3K110.74808254
43MAP3K80.74662994
44STK160.73890672
45TESK20.72401199
46LIMK10.70366219
47BMX0.70203117
48DMPK0.68428525
49STK100.67977956
50ITK0.66251224
51PRKAA20.66085380
52CDK90.60258195
53CDC42BPA0.60237539
54MAP3K30.59309862
55DAPK30.57869005
56MAP3K90.57741636
57FER0.55739236
58FGFR40.55533165
59RIPK40.54419952
60PRKCI0.50229214
61IRAK10.50225681
62PDGFRA0.50147132
63IRAK30.49441853
64TRIB30.48705197
65TEC0.48526725
66CHUK0.48368606
67DYRK1B0.46874722
68NLK0.46573388
69JAK20.46025022
70KDR0.43638742
71BRAF0.43045477
72EPHB10.42322516
73TTK0.41411911
74SMG10.41203702
75PTK20.40990016
76ZAP700.40565775
77MAPK110.39766932
78GRK10.39371279
79PRKACG0.37838771
80MAP3K60.37553011
81CAMKK10.37255980
82CAMK2G0.36988332
83MAP3K130.35988571
84CAMK1D0.35956296
85RET0.34307314
86TYK20.34160840
87PBK0.34144846
88CSK0.34091428
89GRK50.32927917
90MAP4K10.32417284
91MELK0.31593991
92CAMK2B0.31315295
93EPHA30.31264003
94CDK190.30558654
95IRAK40.29490996
96EEF2K0.28739185
97AKT30.28461801
98NEK60.28266661
99DDR20.28167766
100PDPK10.27608415
101PAK40.27512009
102PRKCZ0.27105834
103PIK3CG0.27070211
104SIK10.26833490
105PRKCA0.26673721
106RIPK10.26315136
107LRRK20.26261519
108PDGFRB0.25993193
109PRKAA10.25515343
110PAK10.25445272
111MAPK150.25360301
112PRKCD0.24413277
113MAPKAPK20.23940015
114SRC0.23328578
115ABL20.23104956
116TTN0.22658577
117ERBB20.21983555
118RAF10.21978448
119NUAK10.21792173
120ILK0.21639840
121MAPKAPK30.21529518
122MAP2K60.20559675
123STK240.19975553
124PKN20.19193469
125LCK0.18972732
126RPS6KA20.18496426
127PRKCQ0.17545359
128AURKB0.17253805
129PDK10.17099320
130MAP3K100.16305843
131MOS0.16193978
132PRKD20.16048573
133MUSK0.15982042
134BMPR20.15837697
135FGFR30.15512722
136FYN0.15498286
137BCR0.15228675
138TGFBR20.15151364

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009207.59256175
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.64068681
3Mineral absorption_Homo sapiens_hsa049784.22332605
4Fat digestion and absorption_Homo sapiens_hsa049753.07814627
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.74368709
6Linoleic acid metabolism_Homo sapiens_hsa005912.71377351
7Arginine biosynthesis_Homo sapiens_hsa002202.52931533
8Sulfur relay system_Homo sapiens_hsa041221.94533607
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93628001
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92680573
11Histidine metabolism_Homo sapiens_hsa003401.88179899
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.85063387
13Oxidative phosphorylation_Homo sapiens_hsa001901.80614871
14Bile secretion_Homo sapiens_hsa049761.75944498
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69794689
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69656913
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68990088
18Fructose and mannose metabolism_Homo sapiens_hsa000511.60906261
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.58064036
20Galactose metabolism_Homo sapiens_hsa000521.48198096
21Chemical carcinogenesis_Homo sapiens_hsa052041.45834956
22Parkinsons disease_Homo sapiens_hsa050121.40962309
23Arginine and proline metabolism_Homo sapiens_hsa003301.40516207
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39987394
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39387764
26Pancreatic secretion_Homo sapiens_hsa049721.36284094
27Alzheimers disease_Homo sapiens_hsa050101.35164707
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33356075
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.31803745
30Arachidonic acid metabolism_Homo sapiens_hsa005901.30008312
31Thyroid cancer_Homo sapiens_hsa052161.28714889
32Ether lipid metabolism_Homo sapiens_hsa005651.27279249
33Nitrogen metabolism_Homo sapiens_hsa009101.23071555
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.21710827
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20657570
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18791421
37Tight junction_Homo sapiens_hsa045301.17892133
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14991001
39Phenylalanine metabolism_Homo sapiens_hsa003601.08741529
40Bladder cancer_Homo sapiens_hsa052191.05248825
41Sphingolipid metabolism_Homo sapiens_hsa006001.02633104
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02215197
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.98492702
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88125976
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87762001
46Hepatitis C_Homo sapiens_hsa051600.86721292
47Starch and sucrose metabolism_Homo sapiens_hsa005000.85623560
48Caffeine metabolism_Homo sapiens_hsa002320.85111520
49Salivary secretion_Homo sapiens_hsa049700.83845793
50Glutathione metabolism_Homo sapiens_hsa004800.81721781
51Regulation of autophagy_Homo sapiens_hsa041400.80597639
52Huntingtons disease_Homo sapiens_hsa050160.79743351
53Vitamin digestion and absorption_Homo sapiens_hsa049770.79578545
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.77891084
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.77806472
56African trypanosomiasis_Homo sapiens_hsa051430.76681815
57Primary immunodeficiency_Homo sapiens_hsa053400.71695845
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70665723
59Adherens junction_Homo sapiens_hsa045200.70550178
60Retinol metabolism_Homo sapiens_hsa008300.68847656
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68211315
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68200961
63Protein digestion and absorption_Homo sapiens_hsa049740.68005274
64Renin-angiotensin system_Homo sapiens_hsa046140.66749704
65Salmonella infection_Homo sapiens_hsa051320.66491132
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64189725
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64042341
68Glycerolipid metabolism_Homo sapiens_hsa005610.62995811
69Tyrosine metabolism_Homo sapiens_hsa003500.62957884
70PPAR signaling pathway_Homo sapiens_hsa033200.62167224
71Cardiac muscle contraction_Homo sapiens_hsa042600.61937039
72Tryptophan metabolism_Homo sapiens_hsa003800.61658219
73Folate biosynthesis_Homo sapiens_hsa007900.60336740
74Other glycan degradation_Homo sapiens_hsa005110.59742028
75Asthma_Homo sapiens_hsa053100.59615939
76ABC transporters_Homo sapiens_hsa020100.56278144
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.54661394
78Legionellosis_Homo sapiens_hsa051340.51478507
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.50242319
80Butanoate metabolism_Homo sapiens_hsa006500.49954016
81Pentose phosphate pathway_Homo sapiens_hsa000300.49925374
82Pertussis_Homo sapiens_hsa051330.49401119
83Gastric acid secretion_Homo sapiens_hsa049710.48947208
84Fatty acid degradation_Homo sapiens_hsa000710.47747939
85Fatty acid metabolism_Homo sapiens_hsa012120.47384214
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47019224
87Staphylococcus aureus infection_Homo sapiens_hsa051500.46655876
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46198412
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46197075
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44774847
91Circadian rhythm_Homo sapiens_hsa047100.39450971
92Renin secretion_Homo sapiens_hsa049240.39191671
93Hematopoietic cell lineage_Homo sapiens_hsa046400.38360049
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37794727
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36970345
96Peroxisome_Homo sapiens_hsa041460.36933103
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36861768
98Fatty acid elongation_Homo sapiens_hsa000620.36269269
99Autoimmune thyroid disease_Homo sapiens_hsa053200.34664179
100Allograft rejection_Homo sapiens_hsa053300.33718318
101Inositol phosphate metabolism_Homo sapiens_hsa005620.33081571
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32012330
103Dorso-ventral axis formation_Homo sapiens_hsa043200.31396462
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29658791
105Leishmaniasis_Homo sapiens_hsa051400.29259020
106T cell receptor signaling pathway_Homo sapiens_hsa046600.28754522
107Graft-versus-host disease_Homo sapiens_hsa053320.27907349
108GnRH signaling pathway_Homo sapiens_hsa049120.27855021
109ECM-receptor interaction_Homo sapiens_hsa045120.27783992
110TNF signaling pathway_Homo sapiens_hsa046680.27607794
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.26568587
112Carbon metabolism_Homo sapiens_hsa012000.25792313
113Thyroid hormone synthesis_Homo sapiens_hsa049180.25694496
114Toxoplasmosis_Homo sapiens_hsa051450.24768798
115Metabolic pathways_Homo sapiens_hsa011000.22434940
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21821655
117Biosynthesis of amino acids_Homo sapiens_hsa012300.21642943
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21543516
119Insulin resistance_Homo sapiens_hsa049310.20821846
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20241895
121Vibrio cholerae infection_Homo sapiens_hsa051100.18782495
122Fatty acid biosynthesis_Homo sapiens_hsa000610.18128324
123Antigen processing and presentation_Homo sapiens_hsa046120.17955724
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17515418
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17019282
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.16634416
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14893864
128Amoebiasis_Homo sapiens_hsa051460.13914823
129Complement and coagulation cascades_Homo sapiens_hsa046100.12431315
130Type I diabetes mellitus_Homo sapiens_hsa049400.12150197
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.11377285
132Pyruvate metabolism_Homo sapiens_hsa006200.11085623
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.09429976
134Endocytosis_Homo sapiens_hsa041440.08107803
135beta-Alanine metabolism_Homo sapiens_hsa004100.07126356
136Cocaine addiction_Homo sapiens_hsa050300.06673733
137Ovarian steroidogenesis_Homo sapiens_hsa049130.06589422

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