SDCBPP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of thymocyte apoptotic process (GO:0070244)6.00033295
2proteasome assembly (GO:0043248)4.92410958
3water-soluble vitamin biosynthetic process (GO:0042364)4.91692061
4regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.89240158
5negative regulation of neurological system process (GO:0031645)4.71526498
6histamine secretion (GO:0001821)4.51250865
7DNA deamination (GO:0045006)4.30791393
8tryptophan catabolic process (GO:0006569)4.16102992
9indole-containing compound catabolic process (GO:0042436)4.16102992
10indolalkylamine catabolic process (GO:0046218)4.16102992
11adenosine metabolic process (GO:0046085)4.09751285
12neural tube formation (GO:0001841)4.03262815
13platelet dense granule organization (GO:0060155)4.00960701
14kynurenine metabolic process (GO:0070189)4.00865971
15positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.95942913
16regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.95942913
17tryptophan metabolic process (GO:0006568)3.91042102
18respiratory chain complex IV assembly (GO:0008535)3.85683320
19aggressive behavior (GO:0002118)3.82465204
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.77996862
21behavioral response to nicotine (GO:0035095)3.66917742
22cytochrome complex assembly (GO:0017004)3.66083915
23lactate metabolic process (GO:0006089)3.59111767
24regulation of podosome assembly (GO:0071801)3.58495985
25histamine transport (GO:0051608)3.48715873
26kidney morphogenesis (GO:0060993)3.44624188
27cornea development in camera-type eye (GO:0061303)3.38348858
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36094644
29regulation of glucokinase activity (GO:0033131)3.34508278
30regulation of hexokinase activity (GO:1903299)3.34508278
31protein-cofactor linkage (GO:0018065)3.33755019
32Peyers patch development (GO:0048541)3.33552921
33mucosal-associated lymphoid tissue development (GO:0048537)3.33552921
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31640169
35protein prenylation (GO:0018342)3.25573758
36prenylation (GO:0097354)3.25573758
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23157533
38gamma-aminobutyric acid transport (GO:0015812)3.22902625
39regulation of isotype switching to IgG isotypes (GO:0048302)3.22226833
40L-fucose catabolic process (GO:0042355)3.21400362
41fucose catabolic process (GO:0019317)3.21400362
42L-fucose metabolic process (GO:0042354)3.21400362
43amine catabolic process (GO:0009310)3.20416054
44cellular biogenic amine catabolic process (GO:0042402)3.20416054
45positive regulation of defense response to virus by host (GO:0002230)3.19955723
46negative regulation of transcription regulatory region DNA binding (GO:2000678)3.18479927
47regulation of thymocyte apoptotic process (GO:0070243)3.12468708
48histone mRNA catabolic process (GO:0071044)3.12312673
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.12269883
50indolalkylamine metabolic process (GO:0006586)3.11954003
51coenzyme catabolic process (GO:0009109)3.10727778
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.09975781
53activated T cell proliferation (GO:0050798)3.09561809
54cytidine metabolic process (GO:0046087)3.09362584
55cytidine catabolic process (GO:0006216)3.09362584
56cytidine deamination (GO:0009972)3.09362584
57photoreceptor cell maintenance (GO:0045494)3.06045453
58branched-chain amino acid catabolic process (GO:0009083)3.02301201
59positive regulation of protein homodimerization activity (GO:0090073)2.99955656
60L-ascorbic acid metabolic process (GO:0019852)2.97676158
61mannosylation (GO:0097502)2.97204420
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96613174
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96613174
64behavioral response to ethanol (GO:0048149)2.95551608
65negative regulation of T cell apoptotic process (GO:0070233)2.90144142
66piRNA metabolic process (GO:0034587)2.87818443
67artery smooth muscle contraction (GO:0014824)2.86278150
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.85907558
69regulation of smooth muscle cell apoptotic process (GO:0034391)2.83529684
70regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.80999195
71protein neddylation (GO:0045116)2.80567734
72regulation of vitamin D biosynthetic process (GO:0060556)2.80122900
73peroxisome fission (GO:0016559)2.78711764
74regulation of relaxation of muscle (GO:1901077)2.76534222
75L-methionine salvage (GO:0071267)2.75834297
76L-methionine biosynthetic process (GO:0071265)2.75834297
77amino acid salvage (GO:0043102)2.75834297
78regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.75205526
79protein targeting to Golgi (GO:0000042)2.72618390
80cellular response to ATP (GO:0071318)2.70583121
81positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.70567922
82replication fork processing (GO:0031297)2.70141235
83maturation of 5.8S rRNA (GO:0000460)2.68692417
84establishment of protein localization to Golgi (GO:0072600)2.68243823
85negative regulation of mast cell activation (GO:0033004)2.67403704
86response to pheromone (GO:0019236)2.67347105
87intracellular protein transmembrane import (GO:0044743)2.66622373
88endothelium development (GO:0003158)2.66326347
89negative regulation of DNA-dependent DNA replication (GO:2000104)2.65660469
90RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64856026
91negative regulation of metanephros development (GO:0072217)2.64286855
92aldehyde catabolic process (GO:0046185)2.63343184
93regulation of clathrin-mediated endocytosis (GO:2000369)2.61654689
94branched-chain amino acid metabolic process (GO:0009081)2.60055177
95vitamin biosynthetic process (GO:0009110)2.58873150
96regulation of MHC class II biosynthetic process (GO:0045346)2.58755800
97protein localization to cilium (GO:0061512)2.54501578
98protein localization to Golgi apparatus (GO:0034067)2.54448562
99epithelial cilium movement (GO:0003351)2.52722593
100signal peptide processing (GO:0006465)2.52654302

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.84629532
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.28693261
3VDR_22108803_ChIP-Seq_LS180_Human2.96799540
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77011219
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69638833
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.58856161
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.53333991
8EWS_26573619_Chip-Seq_HEK293_Human2.31076227
9GBX2_23144817_ChIP-Seq_PC3_Human2.30577118
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26302304
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18426116
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09181832
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07850108
14SRF_21415370_ChIP-Seq_HL-1_Mouse1.87757598
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87671391
16P300_19829295_ChIP-Seq_ESCs_Human1.87601103
17VDR_23849224_ChIP-Seq_CD4+_Human1.87493626
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.86256171
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82616983
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.79806225
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74748069
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74129914
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71614739
24MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.71278042
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70589051
26ELK1_19687146_ChIP-ChIP_HELA_Human1.70286488
27FUS_26573619_Chip-Seq_HEK293_Human1.69818193
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67716937
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66748088
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65239957
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.63353894
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54833969
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54113858
34ER_23166858_ChIP-Seq_MCF-7_Human1.53533660
35SOX2_19829295_ChIP-Seq_ESCs_Human1.53061299
36NANOG_19829295_ChIP-Seq_ESCs_Human1.53061299
37IGF1R_20145208_ChIP-Seq_DFB_Human1.50246269
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48947090
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48421825
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47462086
41CBP_20019798_ChIP-Seq_JUKART_Human1.47462086
42TP53_22573176_ChIP-Seq_HFKS_Human1.45174982
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43199772
44MYC_18940864_ChIP-ChIP_HL60_Human1.42388188
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39178174
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37128423
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37095593
48BCAT_22108803_ChIP-Seq_LS180_Human1.36826055
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33481301
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.33481301
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31889814
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31889814
53TAF15_26573619_Chip-Seq_HEK293_Human1.29938176
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.28194852
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28095527
56IRF1_19129219_ChIP-ChIP_H3396_Human1.24702225
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23108107
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.21567728
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21475223
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.21225059
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20903564
62HTT_18923047_ChIP-ChIP_STHdh_Human1.19425282
63SALL4_22934838_ChIP-ChIP_CD34+_Human1.18272527
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17652853
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.15957211
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.15854699
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15285897
68FOXP3_21729870_ChIP-Seq_TREG_Human1.12432086
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12415029
70CDX2_22108803_ChIP-Seq_LS180_Human1.12027134
71AR_25329375_ChIP-Seq_VCAP_Human1.11271209
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10571018
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.09893169
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09665819
75NANOG_20526341_ChIP-Seq_ESCs_Human1.08611095
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08348903
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.06754623
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05851795
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.04885928
80TCF4_23295773_ChIP-Seq_U87_Human1.04729633
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04626309
82RUNX2_22187159_ChIP-Seq_PCA_Human1.04009256
83GATA3_26560356_Chip-Seq_TH2_Human1.03140372
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02973457
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02347817
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02191371
87TCF4_22108803_ChIP-Seq_LS180_Human1.01625447
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01432322
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01271777
90STAT3_18555785_Chip-Seq_ESCs_Mouse0.99621681
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.99596684
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99343338
93SMAD4_21799915_ChIP-Seq_A2780_Human0.98306094
94AR_20517297_ChIP-Seq_VCAP_Human0.98166984
95P53_22387025_ChIP-Seq_ESCs_Mouse0.97740935
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.96258796
97STAT3_23295773_ChIP-Seq_U87_Human0.95869602
98ERG_20517297_ChIP-Seq_VCAP_Human0.94969138
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94411770
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93894653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation3.55968186
2MP0009780_abnormal_chondrocyte_physiolo3.43589597
3MP0006054_spinal_hemorrhage3.39694116
4MP0004084_abnormal_cardiac_muscle3.16734778
5MP0002837_dystrophic_cardiac_calcinosis2.81963272
6MP0002102_abnormal_ear_morphology2.60604725
7MP0005075_abnormal_melanosome_morpholog2.51487383
8MP0000372_irregular_coat_pigmentation2.37520893
9MP0004215_abnormal_myocardial_fiber2.35302333
10MP0000516_abnormal_urinary_system2.23121236
11MP0005367_renal/urinary_system_phenotyp2.23121236
12MP0002736_abnormal_nociception_after2.15503312
13MP0008875_abnormal_xenobiotic_pharmacok2.11738190
14MP0002254_reproductive_system_inflammat2.08760860
15MP0005084_abnormal_gallbladder_morpholo2.07827927
16MP0003718_maternal_effect2.05659317
17MP0001835_abnormal_antigen_presentation2.05368635
18MP0003787_abnormal_imprinting2.02361531
19MP0008775_abnormal_heart_ventricle1.94576427
20MP0005551_abnormal_eye_electrophysiolog1.92230535
21MP0002928_abnormal_bile_duct1.90424664
22MP0003252_abnormal_bile_duct1.88094968
23MP0001984_abnormal_olfaction1.84042978
24MP0005253_abnormal_eye_physiology1.81718459
25MP0004782_abnormal_surfactant_physiolog1.81632478
26MP0002876_abnormal_thyroid_physiology1.81508527
27MP0003195_calcinosis1.81087134
28MP0005646_abnormal_pituitary_gland1.73820064
29MP0005645_abnormal_hypothalamus_physiol1.65883247
30MP0003806_abnormal_nucleotide_metabolis1.63166659
31MP0001986_abnormal_taste_sensitivity1.62264306
32MP0001764_abnormal_homeostasis1.60734634
33MP0010352_gastrointestinal_tract_polyps1.56124165
34MP0008872_abnormal_physiological_respon1.55708333
35MP0008058_abnormal_DNA_repair1.53363246
36MP0001968_abnormal_touch/_nociception1.50177593
37MP0004036_abnormal_muscle_relaxation1.47736028
38MP0003186_abnormal_redox_activity1.45590036
39MP0005167_abnormal_blood-brain_barrier1.42347047
40MP0008877_abnormal_DNA_methylation1.39926685
41MP0005671_abnormal_response_to1.37611601
42MP0005171_absent_coat_pigmentation1.33090879
43MP0001873_stomach_inflammation1.30101114
44MP0001501_abnormal_sleep_pattern1.28719266
45MP0003011_delayed_dark_adaptation1.24331264
46MP0004484_altered_response_of1.21441751
47MP0000230_abnormal_systemic_arterial1.19654220
48MP0001485_abnormal_pinna_reflex1.18484116
49MP0001958_emphysema1.18261450
50MP0002234_abnormal_pharynx_morphology1.16754936
51MP0005377_hearing/vestibular/ear_phenot1.16522347
52MP0003878_abnormal_ear_physiology1.16522347
53MP0002148_abnormal_hypersensitivity_rea1.16204300
54MP0010368_abnormal_lymphatic_system1.13960286
55MP0005174_abnormal_tail_pigmentation1.09832424
56MP0000427_abnormal_hair_cycle1.04734689
57MP0002095_abnormal_skin_pigmentation1.03802704
58MP0000049_abnormal_middle_ear1.03419117
59MP0002272_abnormal_nervous_system1.03237904
60MP0009785_altered_susceptibility_to1.01865370
61MP0005165_increased_susceptibility_to1.01380321
62MP0008004_abnormal_stomach_pH0.98130735
63MP0002938_white_spotting0.96845008
64MP0006072_abnormal_retinal_apoptosis0.95291417
65MP0001324_abnormal_eye_pigmentation0.94064522
66MP0009764_decreased_sensitivity_to0.92001402
67MP0005410_abnormal_fertilization0.91908763
68MP0010155_abnormal_intestine_physiology0.90624363
69MP0009333_abnormal_splenocyte_physiolog0.89037894
70MP0005647_abnormal_sex_gland0.88986859
71MP0003880_abnormal_central_pattern0.88984756
72MP0009046_muscle_twitch0.87054784
73MP0008789_abnormal_olfactory_epithelium0.86899374
74MP0002751_abnormal_autonomic_nervous0.86829923
75MP0000371_diluted_coat_color0.86696920
76MP0000569_abnormal_digit_pigmentation0.86264171
77MP0009765_abnormal_xenobiotic_induced0.86187911
78MP0001270_distended_abdomen0.85597264
79MP0005379_endocrine/exocrine_gland_phen0.81592185
80MP0005395_other_phenotype0.80534772
81MP0008007_abnormal_cellular_replicative0.80486206
82MP0010234_abnormal_vibrissa_follicle0.79328017
83MP0003724_increased_susceptibility_to0.76848610
84MP0001486_abnormal_startle_reflex0.76707105
85MP0001905_abnormal_dopamine_level0.75384943
86MP0004885_abnormal_endolymph0.74967756
87MP0002405_respiratory_system_inflammati0.73899976
88MP0002090_abnormal_vision0.73142132
89MP0010678_abnormal_skin_adnexa0.71937661
90MP0002006_tumorigenesis0.71243998
91MP0006035_abnormal_mitochondrial_morpho0.68989134
92MP0002572_abnormal_emotion/affect_behav0.68868249
93MP0005464_abnormal_platelet_physiology0.68430815
94MP0005408_hypopigmentation0.66542235
95MP0009745_abnormal_behavioral_response0.65410487
96MP0000383_abnormal_hair_follicle0.63723846
97MP0001177_atelectasis0.63082732
98MP0003121_genomic_imprinting0.63056225
99MP0003448_altered_tumor_morphology0.61337907
100MP0003866_abnormal_defecation0.60935754

Predicted human phenotypes

RankGene SetZ-score
1Tubular atrophy (HP:0000092)4.23107273
2Pancreatic fibrosis (HP:0100732)4.05538686
3Pancreatic cysts (HP:0001737)3.85211596
4Mesangial abnormality (HP:0001966)3.82558997
5Opisthotonus (HP:0002179)3.69655917
6Abnormality of the renal cortex (HP:0011035)3.53456545
7Abolished electroretinogram (ERG) (HP:0000550)3.36535340
8Nephronophthisis (HP:0000090)3.31324492
9Hypoproteinemia (HP:0003075)3.24092871
10Congenital stationary night blindness (HP:0007642)3.16770661
11Renal cortical cysts (HP:0000803)3.12274599
12Thyroid-stimulating hormone excess (HP:0002925)3.10599632
13True hermaphroditism (HP:0010459)3.08927312
14Neonatal respiratory distress (HP:0002643)3.08600967
15Abnormality of the renal medulla (HP:0100957)3.06804031
16Cutaneous melanoma (HP:0012056)3.06306295
17Dyschromatopsia (HP:0007641)2.94717987
18Abnormal biliary tract physiology (HP:0012439)2.85755334
19Bile duct proliferation (HP:0001408)2.85755334
20Thyroiditis (HP:0100646)2.84057198
21Hemiparesis (HP:0001269)2.79605107
22Abnormal drinking behavior (HP:0030082)2.77251027
23Polydipsia (HP:0001959)2.77251027
24Dry hair (HP:0011359)2.69952949
25Increased CSF lactate (HP:0002490)2.63540476
26Nausea (HP:0002018)2.62459943
27Redundant skin (HP:0001582)2.58636703
283-Methylglutaconic aciduria (HP:0003535)2.49728390
29Unilateral renal agenesis (HP:0000122)2.44151652
30Hypoplastic pelvis (HP:0008839)2.43875814
31Cystic liver disease (HP:0006706)2.42880473
32Congenital, generalized hypertrichosis (HP:0004540)2.42207182
33Polyuria (HP:0000103)2.40947866
34Increased serum pyruvate (HP:0003542)2.39554281
35Hypoalbuminemia (HP:0003073)2.38427484
36Abnormal albumin level (HP:0012116)2.38427484
37Inability to walk (HP:0002540)2.36979941
38Widely patent fontanelles and sutures (HP:0004492)2.36662847
39Tubulointerstitial abnormality (HP:0001969)2.33438944
40Methylmalonic acidemia (HP:0002912)2.30120843
41Progressive microcephaly (HP:0000253)2.27023848
42Decreased central vision (HP:0007663)2.26700203
43Congenital hepatic fibrosis (HP:0002612)2.24111140
44Hyperglycinuria (HP:0003108)2.24076795
45Abnormal rod and cone electroretinograms (HP:0008323)2.23100379
46Optic disc pallor (HP:0000543)2.20610028
47Tubulointerstitial nephritis (HP:0001970)2.19952630
48Horizontal nystagmus (HP:0000666)2.18430595
49Attenuation of retinal blood vessels (HP:0007843)2.17746862
50Menstrual irregularities (HP:0000858)2.17371374
51Increased serum lactate (HP:0002151)2.17063583
52Hyperglycinemia (HP:0002154)2.16769768
53Pendular nystagmus (HP:0012043)2.16208142
54Mitochondrial inheritance (HP:0001427)2.16031020
55Progressive macrocephaly (HP:0004481)2.15110130
56Abnormality of alanine metabolism (HP:0010916)2.13844642
57Hyperalaninemia (HP:0003348)2.13844642
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13844642
59Supernumerary spleens (HP:0009799)2.13325255
60Increased corneal curvature (HP:0100692)2.12891588
61Keratoconus (HP:0000563)2.12891588
62Septo-optic dysplasia (HP:0100842)2.10856227
63Anhidrosis (HP:0000970)2.08467691
64Gaze-evoked nystagmus (HP:0000640)2.05770403
65Hepatocellular necrosis (HP:0001404)2.05264143
66Hypoplasia of the fovea (HP:0007750)2.05247718
67Aplasia/Hypoplasia of the fovea (HP:0008060)2.05247718
68Decreased lacrimation (HP:0000633)2.05206687
69Adrenal hypoplasia (HP:0000835)2.04261208
70Spontaneous abortion (HP:0005268)2.03958148
71Tubulointerstitial fibrosis (HP:0005576)2.03949465
72Spastic paraparesis (HP:0002313)2.01736993
73Type I transferrin isoform profile (HP:0003642)2.00118150
74Hepatic necrosis (HP:0002605)2.00113806
75Aplasia/Hypoplasia of the spleen (HP:0010451)1.98470737
76Facial diplegia (HP:0001349)1.95306347
77Hyperventilation (HP:0002883)1.94240695
78Poor head control (HP:0002421)1.92129298
79Acute necrotizing encephalopathy (HP:0006965)1.91496355
80Delayed gross motor development (HP:0002194)1.88713751
81Ependymoma (HP:0002888)1.88154907
82Hyperthyroidism (HP:0000836)1.88102300
83Abnormality of B cell number (HP:0010975)1.87829012
84Potter facies (HP:0002009)1.87144883
85Facial shape deformation (HP:0011334)1.87144883
86Lipid accumulation in hepatocytes (HP:0006561)1.84578337
87Abnormal delayed hypersensitivity skin test (HP:0002963)1.83831327
88Abnormal urine output (HP:0012590)1.82815361
89Panhypogammaglobulinemia (HP:0003139)1.82368208
90CNS demyelination (HP:0007305)1.82147273
91Asplenia (HP:0001746)1.81512803
92Furrowed tongue (HP:0000221)1.80149490
93Abnormal auditory evoked potentials (HP:0006958)1.80056352
94Sclerocornea (HP:0000647)1.79774837
95Abnormality of the heme biosynthetic pathway (HP:0010472)1.79314989
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79159638
97Abnormality of glycine metabolism (HP:0010895)1.79104594
98Abnormality of serine family amino acid metabolism (HP:0010894)1.79104594
99Autoimmune thrombocytopenia (HP:0001973)1.78869588
100Acute encephalopathy (HP:0006846)1.78448275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.16121548
2MST44.01787655
3TAOK33.75971606
4TIE13.19512887
5TXK3.12106724
6MAP4K22.96703128
7NUAK12.33108071
8PINK12.12576861
9ZAK2.01632078
10WNK31.89491111
11GRK11.87364571
12TLK11.85868901
13TSSK61.78956641
14EPHA31.76776756
15ADRBK21.76134601
16MAP3K141.75674070
17BMPR1B1.74624722
18NEK11.73515164
19EIF2AK31.70431307
20TRIM281.62972953
21ERBB31.48845925
22PTK2B1.48543077
23BCR1.36001035
24MAPK131.31395256
25PHKG11.28158209
26PHKG21.28158209
27STK38L1.26706984
28PBK1.23287830
29STK31.18855038
30TEC1.15809684
31ACVR1B1.14739118
32PLK31.12479612
33STK391.11026718
34ADRBK11.08714865
35FGFR21.07205704
36RPS6KA51.06646351
37FER1.06067767
38PLK21.05902674
39TGFBR11.03498130
40LIMK11.02217077
41PAK31.01341578
42CSNK1G30.97751607
43STK160.96998923
44IKBKB0.95884819
45PRKCE0.95149923
46OXSR10.92589648
47BCKDK0.91879678
48LATS10.91104533
49EIF2AK10.88728407
50PNCK0.88698869
51CSNK1G20.88334059
52MKNK10.86519490
53CASK0.84272468
54KIT0.82789946
55STK100.82066036
56CSNK1A1L0.80392642
57CSNK1G10.76442766
58TNK20.72461382
59PRKG20.68443831
60IRAK10.66544718
61PRKCQ0.65656343
62MAPKAPK50.64039658
63WNK40.63353637
64CHUK0.59136640
65DYRK30.59044260
66PRKD30.58381847
67VRK10.53348070
68NLK0.52136716
69TGFBR20.50639528
70DAPK20.49628268
71ROCK10.49278144
72FGFR30.47466427
73ALK0.47351175
74MARK10.45227934
75MAP4K10.44574631
76BUB10.43945984
77CCNB10.43173153
78CAMK2A0.40420515
79MATK0.40182270
80MAPK150.39758366
81JAK30.37374033
82CAMK2D0.37195597
83IKBKE0.36016670
84PRKCI0.35684961
85INSRR0.35246861
86PLK10.34979035
87PRKG10.34281615
88PASK0.33966246
89ABL10.32734576
90SIK30.32627444
91PRKCG0.31608223
92ROCK20.31292394
93MINK10.31259036
94PRKACA0.29339621
95WEE10.28827555
96CDC70.28417261
97NME10.27686840
98LCK0.27615719
99IGF1R0.26985811
100BTK0.26395797

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.19988447
2Proteasome_Homo sapiens_hsa030503.97537722
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.34123970
4Butanoate metabolism_Homo sapiens_hsa006502.22691367
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12134717
6Fanconi anemia pathway_Homo sapiens_hsa034601.98493344
7RNA polymerase_Homo sapiens_hsa030201.93936672
8Propanoate metabolism_Homo sapiens_hsa006401.88989935
9Regulation of autophagy_Homo sapiens_hsa041401.88720378
10Rheumatoid arthritis_Homo sapiens_hsa053231.88697910
11Oxidative phosphorylation_Homo sapiens_hsa001901.86485294
12Phototransduction_Homo sapiens_hsa047441.84142024
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81664307
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80660362
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79579337
16Linoleic acid metabolism_Homo sapiens_hsa005911.78471279
17Basal transcription factors_Homo sapiens_hsa030221.74944130
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72836023
19One carbon pool by folate_Homo sapiens_hsa006701.67182843
20RNA degradation_Homo sapiens_hsa030181.63912073
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62412475
22Nitrogen metabolism_Homo sapiens_hsa009101.62291990
23Homologous recombination_Homo sapiens_hsa034401.49956376
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47313839
25Sulfur metabolism_Homo sapiens_hsa009201.45656176
26Tryptophan metabolism_Homo sapiens_hsa003801.43136176
27Collecting duct acid secretion_Homo sapiens_hsa049661.40945289
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39149328
29Olfactory transduction_Homo sapiens_hsa047401.35597432
30Selenocompound metabolism_Homo sapiens_hsa004501.32437555
31Arachidonic acid metabolism_Homo sapiens_hsa005901.30172961
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29967700
33Peroxisome_Homo sapiens_hsa041461.23719284
34Antigen processing and presentation_Homo sapiens_hsa046121.18375028
35Type I diabetes mellitus_Homo sapiens_hsa049401.13479594
36Ether lipid metabolism_Homo sapiens_hsa005651.10750853
37Parkinsons disease_Homo sapiens_hsa050121.08153359
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06762080
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.06745104
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04809508
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01675782
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.99880437
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99226154
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98839286
45Chemical carcinogenesis_Homo sapiens_hsa052040.95338551
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91132911
47Caffeine metabolism_Homo sapiens_hsa002320.88310640
48Nucleotide excision repair_Homo sapiens_hsa034200.86419468
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85538366
50Allograft rejection_Homo sapiens_hsa053300.81504611
51Purine metabolism_Homo sapiens_hsa002300.81491673
52Circadian entrainment_Homo sapiens_hsa047130.80942238
53Folate biosynthesis_Homo sapiens_hsa007900.79526239
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79518874
55Steroid biosynthesis_Homo sapiens_hsa001000.77912603
56Taste transduction_Homo sapiens_hsa047420.76865798
57Glutathione metabolism_Homo sapiens_hsa004800.76046117
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75825190
59N-Glycan biosynthesis_Homo sapiens_hsa005100.74678916
60Primary immunodeficiency_Homo sapiens_hsa053400.73639938
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71993448
62Serotonergic synapse_Homo sapiens_hsa047260.70906807
63Retinol metabolism_Homo sapiens_hsa008300.70172851
64Mismatch repair_Homo sapiens_hsa034300.69798080
65Morphine addiction_Homo sapiens_hsa050320.68708479
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67533054
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66503173
68Fat digestion and absorption_Homo sapiens_hsa049750.66288946
69RNA transport_Homo sapiens_hsa030130.65111678
70African trypanosomiasis_Homo sapiens_hsa051430.64291804
71Systemic lupus erythematosus_Homo sapiens_hsa053220.61964747
72Graft-versus-host disease_Homo sapiens_hsa053320.60329543
73Renin secretion_Homo sapiens_hsa049240.59793428
74Salivary secretion_Homo sapiens_hsa049700.58836028
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57196347
76GABAergic synapse_Homo sapiens_hsa047270.56726188
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.54923501
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54918726
79ABC transporters_Homo sapiens_hsa020100.53898869
80Alzheimers disease_Homo sapiens_hsa050100.53244348
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51475826
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.50350589
83Metabolic pathways_Homo sapiens_hsa011000.50289328
84beta-Alanine metabolism_Homo sapiens_hsa004100.50265768
85Sphingolipid metabolism_Homo sapiens_hsa006000.50243239
86Nicotine addiction_Homo sapiens_hsa050330.49959701
87Non-homologous end-joining_Homo sapiens_hsa034500.49723004
88Tyrosine metabolism_Homo sapiens_hsa003500.47255986
89Insulin secretion_Homo sapiens_hsa049110.45889073
90Huntingtons disease_Homo sapiens_hsa050160.45513507
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43983272
92Glycerolipid metabolism_Homo sapiens_hsa005610.43820287
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43205868
94Malaria_Homo sapiens_hsa051440.42855288
95TGF-beta signaling pathway_Homo sapiens_hsa043500.40437233
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.39891387
97Alcoholism_Homo sapiens_hsa050340.38966116
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38335312
99Circadian rhythm_Homo sapiens_hsa047100.37170145
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.36035885

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