SDCBPP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interleukin-12 biosynthetic process (GO:0045075)5.72523821
2protein neddylation (GO:0045116)5.49183477
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.44332909
4lysine catabolic process (GO:0006554)5.02243417
5lysine metabolic process (GO:0006553)5.02243417
6regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.84037005
7response to nitrosative stress (GO:0051409)4.65903263
8platelet dense granule organization (GO:0060155)4.59672726
9positive regulation of T cell cytokine production (GO:0002726)4.31293674
10proteasome assembly (GO:0043248)4.28353248
11cytidine catabolic process (GO:0006216)4.13514684
12cytidine deamination (GO:0009972)4.13514684
13cytidine metabolic process (GO:0046087)4.13514684
14DNA deamination (GO:0045006)4.12359656
15regulation of isotype switching to IgG isotypes (GO:0048302)3.98499769
16cysteine metabolic process (GO:0006534)3.97794834
17positive regulation of T-helper 1 type immune response (GO:0002827)3.92605672
18regulation of T cell chemotaxis (GO:0010819)3.88593511
19positive regulation of T cell chemotaxis (GO:0010820)3.88593511
20aspartate family amino acid catabolic process (GO:0009068)3.80436544
21tryptophan metabolic process (GO:0006568)3.76914474
22signal peptide processing (GO:0006465)3.73884268
23negative regulation of T cell differentiation in thymus (GO:0033085)3.66475299
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59652656
25viral mRNA export from host cell nucleus (GO:0046784)3.55039537
26regulation of T-helper 1 type immune response (GO:0002825)3.41398139
27valine metabolic process (GO:0006573)3.37209447
28negative regulation of thymocyte apoptotic process (GO:0070244)3.37144096
29S-adenosylmethionine metabolic process (GO:0046500)3.36758890
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.36123973
31kynurenine metabolic process (GO:0070189)3.34563774
32negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34172469
33positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.31738257
34pyrimidine ribonucleoside catabolic process (GO:0046133)3.23687837
35negative regulation by host of viral transcription (GO:0043922)3.22560413
36tyrosine phosphorylation of STAT protein (GO:0007260)3.17411396
37interferon-gamma production (GO:0032609)3.16690887
38positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14130018
39regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.12838052
40cornea development in camera-type eye (GO:0061303)3.12658743
41positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.12644268
42regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.12644268
43intra-S DNA damage checkpoint (GO:0031573)3.12450774
44regulation of thymocyte apoptotic process (GO:0070243)3.09050890
45mast cell degranulation (GO:0043303)3.06408516
46mast cell activation involved in immune response (GO:0002279)3.06408516
47positive regulation of interleukin-12 production (GO:0032735)3.06222862
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05490854
49negative regulation of production of molecular mediator of immune response (GO:0002701)3.04620507
50negative regulation of meiosis (GO:0045835)2.99769248
51indolalkylamine metabolic process (GO:0006586)2.99503188
52sequestering of actin monomers (GO:0042989)2.96634267
53tryptophan catabolic process (GO:0006569)2.94396989
54indole-containing compound catabolic process (GO:0042436)2.94396989
55indolalkylamine catabolic process (GO:0046218)2.94396989
56left/right axis specification (GO:0070986)2.93575309
57regulation of vitamin D biosynthetic process (GO:0060556)2.92711386
58regulation of gamma-delta T cell differentiation (GO:0045586)2.90677756
59cellular response to interleukin-15 (GO:0071350)2.90374785
60response to interferon-beta (GO:0035456)2.87869523
61negative regulation of cytokine production involved in immune response (GO:0002719)2.85997511
62regulation of regulatory T cell differentiation (GO:0045589)2.84454014
63response to xenobiotic stimulus (GO:0009410)2.83518285
64negative regulation of metanephros development (GO:0072217)2.80088254
65cellular response to ATP (GO:0071318)2.79003188
66positive regulation of muscle cell apoptotic process (GO:0010661)2.78763195
67purine nucleotide salvage (GO:0032261)2.76699261
68negative regulation of neurological system process (GO:0031645)2.75026375
69lipid particle organization (GO:0034389)2.74687384
70adenosine metabolic process (GO:0046085)2.74584172
71cytochrome complex assembly (GO:0017004)2.74449112
72regulation of T cell mediated cytotoxicity (GO:0001914)2.71602053
73regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.70714344
74response to interleukin-15 (GO:0070672)2.70528067
75positive regulation of interleukin-1 secretion (GO:0050716)2.69715225
76regulation of T cell cytokine production (GO:0002724)2.69326544
77response to pheromone (GO:0019236)2.67311163
78gonadal mesoderm development (GO:0007506)2.67188563
79positive regulation of T cell differentiation in thymus (GO:0033089)2.66466722
80positive regulation of interleukin-1 beta secretion (GO:0050718)2.65818735
81positive regulation of DNA recombination (GO:0045911)2.63998530
82regulation of cellular amino acid metabolic process (GO:0006521)2.63904634
83positive regulation of transforming growth factor beta production (GO:0071636)2.62771828
84regulation of vitamin metabolic process (GO:0030656)2.62370272
85mannosylation (GO:0097502)2.62289259
86regulation of translational termination (GO:0006449)2.61792954
87regulation of meiosis I (GO:0060631)2.61508663
88regulation of lymphocyte chemotaxis (GO:1901623)2.60201253
89positive regulation of translational initiation (GO:0045948)2.55514713
90activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.54974333
91aggressive behavior (GO:0002118)2.54361204
92auditory receptor cell stereocilium organization (GO:0060088)2.53388840
93negative regulation of viral genome replication (GO:0045071)2.50823144
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50779845
95positive regulation of isotype switching (GO:0045830)2.50359790
96retinal cone cell development (GO:0046549)2.49998405
97positive regulation of immunoglobulin production (GO:0002639)2.49849491
98deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.45918242
99negative regulation of T cell differentiation (GO:0045581)2.45773273
100lactate metabolic process (GO:0006089)2.44393341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.12801101
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.64566374
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.57012291
4ZNF274_21170338_ChIP-Seq_K562_Hela3.53539811
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.16887113
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98628132
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.95856337
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.86221039
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84045138
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.71650810
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.62317524
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.56414410
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.48144744
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37680546
15VDR_23849224_ChIP-Seq_CD4+_Human2.19511225
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07106987
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96982436
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92045384
19VDR_22108803_ChIP-Seq_LS180_Human1.90868258
20FUS_26573619_Chip-Seq_HEK293_Human1.90275376
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88800100
22ELK1_19687146_ChIP-ChIP_HELA_Human1.79775446
23EWS_26573619_Chip-Seq_HEK293_Human1.79111326
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74673134
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72152351
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68910581
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.68021143
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67469785
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66512173
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65367040
31FOXP3_21729870_ChIP-Seq_TREG_Human1.63885629
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.63720982
33CBP_20019798_ChIP-Seq_JUKART_Human1.63234206
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63234206
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61344317
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60483471
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.59918709
38AR_20517297_ChIP-Seq_VCAP_Human1.59812356
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.55300496
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.55300496
41FOXA1_21572438_ChIP-Seq_LNCaP_Human1.53607211
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51257762
43P300_19829295_ChIP-Seq_ESCs_Human1.46468372
44ER_23166858_ChIP-Seq_MCF-7_Human1.44048154
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43881342
46MYC_18940864_ChIP-ChIP_HL60_Human1.39992140
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.38466897
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38024933
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36220741
50GBX2_23144817_ChIP-Seq_PC3_Human1.31998604
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31030227
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30774677
53GATA3_26560356_Chip-Seq_TH2_Human1.27502113
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27185577
55SOX2_19829295_ChIP-Seq_ESCs_Human1.25733619
56NANOG_19829295_ChIP-Seq_ESCs_Human1.25733619
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20947170
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.19145786
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.16453621
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15834350
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15579926
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.14950414
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13988265
64CDX2_22108803_ChIP-Seq_LS180_Human1.13271473
65EGR1_19032775_ChIP-ChIP_M12_Human1.12876622
66GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.11754589
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11062889
68ERG_20517297_ChIP-Seq_VCAP_Human1.10597862
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10461134
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10204630
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09770328
72TP53_22573176_ChIP-Seq_HFKS_Human1.09443340
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09175641
74NCOR_22424771_ChIP-Seq_293T_Human1.09018355
75MYB_26560356_Chip-Seq_TH2_Human1.08818594
76TCF4_22108803_ChIP-Seq_LS180_Human1.07773789
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07370480
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07240255
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06079469
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05004110
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04033201
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03953902
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03464650
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02971336
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02683128
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01673397
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01059090
88TAF15_26573619_Chip-Seq_HEK293_Human0.98742221
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98168292
90IGF1R_20145208_ChIP-Seq_DFB_Human0.97032347
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95385141
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94395912
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.94179142
94ETS1_20019798_ChIP-Seq_JURKAT_Human0.93567183
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.93199346
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92571440
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92025664
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91883278
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91859102
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.90771461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.57758832
2MP0001835_abnormal_antigen_presentation3.40732214
3MP0002138_abnormal_hepatobiliary_system3.39382940
4MP0009697_abnormal_copulation2.72711694
5MP0002006_tumorigenesis2.56962499
6MP0008877_abnormal_DNA_methylation2.48424822
7MP0005084_abnormal_gallbladder_morpholo2.40444050
8MP0003787_abnormal_imprinting2.30096637
9MP0001873_stomach_inflammation2.21005243
10MP0004147_increased_porphyrin_level2.19510827
11MP0009785_altered_susceptibility_to2.18113019
12MP0000569_abnormal_digit_pigmentation2.12451382
13MP0002102_abnormal_ear_morphology2.11274534
14MP0006054_spinal_hemorrhage2.05078359
15MP0003436_decreased_susceptibility_to2.03364447
16MP0005671_abnormal_response_to1.96377694
17MP0005253_abnormal_eye_physiology1.96083859
18MP0004782_abnormal_surfactant_physiolog1.87461312
19MP0003195_calcinosis1.82440778
20MP0008872_abnormal_physiological_respon1.77347393
21MP0006072_abnormal_retinal_apoptosis1.74934408
22MP0003866_abnormal_defecation1.74305902
23MP0002254_reproductive_system_inflammat1.74136059
24MP0005310_abnormal_salivary_gland1.71297974
25MP0003724_increased_susceptibility_to1.70398866
26MP0005000_abnormal_immune_tolerance1.63240092
27MP0002837_dystrophic_cardiac_calcinosis1.62071692
28MP0003252_abnormal_bile_duct1.61754204
29MP0008775_abnormal_heart_ventricle1.53730263
30MP0010386_abnormal_urinary_bladder1.53315347
31MP0005646_abnormal_pituitary_gland1.52752019
32MP0003718_maternal_effect1.48545660
33MP0001764_abnormal_homeostasis1.47619744
34MP0002405_respiratory_system_inflammati1.47216978
35MP0004084_abnormal_cardiac_muscle1.46819274
36MP0003045_fibrosis1.46083474
37MP0001986_abnormal_taste_sensitivity1.45564401
38MP0000383_abnormal_hair_follicle1.44941970
39MP0002638_abnormal_pupillary_reflex1.43255464
40MP0001800_abnormal_humoral_immune1.42029445
41MP0001790_abnormal_immune_system1.41226212
42MP0005387_immune_system_phenotype1.41226212
43MP0002148_abnormal_hypersensitivity_rea1.40602943
44MP0002166_altered_tumor_susceptibility1.38871412
45MP0005551_abnormal_eye_electrophysiolog1.37431031
46MP0003786_premature_aging1.35336459
47MP0003186_abnormal_redox_activity1.34695296
48MP0002139_abnormal_hepatobiliary_system1.33075188
49MP0001968_abnormal_touch/_nociception1.30374393
50MP0010155_abnormal_intestine_physiology1.29553546
51MP0009764_decreased_sensitivity_to1.27830101
52MP0004043_abnormal_pH_regulation1.24251735
53MP0005167_abnormal_blood-brain_barrier1.20784448
54MP0003011_delayed_dark_adaptation1.17671189
55MP0005647_abnormal_sex_gland1.13800922
56MP0006082_CNS_inflammation1.12348361
57MP0002723_abnormal_immune_serum1.11647706
58MP0002928_abnormal_bile_duct1.11188262
59MP0002933_joint_inflammation1.10888098
60MP0009765_abnormal_xenobiotic_induced1.10844494
61MP0010368_abnormal_lymphatic_system1.10358215
62MP0002736_abnormal_nociception_after1.10014066
63MP0003221_abnormal_cardiomyocyte_apopto1.09101740
64MP0001845_abnormal_inflammatory_respons1.07955250
65MP0003880_abnormal_central_pattern1.05964513
66MP0001958_emphysema1.05180021
67MP0002452_abnormal_antigen_presenting1.04256705
68MP0005410_abnormal_fertilization1.02035889
69MP0002876_abnormal_thyroid_physiology1.00412658
70MP0005025_abnormal_response_to0.99965589
71MP0008995_early_reproductive_senescence0.99769710
72MP0010678_abnormal_skin_adnexa0.98028228
73MP0000613_abnormal_salivary_gland0.97557888
74MP0004142_abnormal_muscle_tone0.96476313
75MP0002420_abnormal_adaptive_immunity0.94819806
76MP0001819_abnormal_immune_cell0.91908100
77MP0005395_other_phenotype0.91642703
78MP0003646_muscle_fatigue0.89324893
79MP0000685_abnormal_immune_system0.87470414
80MP0002090_abnormal_vision0.86857142
81MP0004808_abnormal_hematopoietic_stem0.84906395
82MP0008875_abnormal_xenobiotic_pharmacok0.84539041
83MP0001533_abnormal_skeleton_physiology0.83599260
84MP0002234_abnormal_pharynx_morphology0.83440408
85MP0008469_abnormal_protein_level0.83309288
86MP0008789_abnormal_olfactory_epithelium0.82259953
87MP0003329_amyloid_beta_deposits0.82170379
88MP0009780_abnormal_chondrocyte_physiolo0.81346272
89MP0003279_aneurysm0.79072655
90MP0001881_abnormal_mammary_gland0.78700584
91MP0000689_abnormal_spleen_morphology0.73452578
92MP0001324_abnormal_eye_pigmentation0.70469129
93MP0002168_other_aberrant_phenotype0.69188123
94MP0000604_amyloidosis0.68467598
95MP0004215_abnormal_myocardial_fiber0.68255107
96MP0002419_abnormal_innate_immunity0.67535808
97MP0003890_abnormal_embryonic-extraembry0.66991335
98MP0002136_abnormal_kidney_physiology0.65874122
99MP0002229_neurodegeneration0.64670421
100MP0000639_abnormal_adrenal_gland0.64077228

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)3.56544369
2Hypoproteinemia (HP:0003075)3.51879746
3Pancreatic cysts (HP:0001737)3.51729954
4Abnormality of the renal cortex (HP:0011035)3.51209696
5Panhypogammaglobulinemia (HP:0003139)3.31748000
6Abolished electroretinogram (ERG) (HP:0000550)3.31652887
7Chronic diarrhea (HP:0002028)3.28590423
8Mesangial abnormality (HP:0001966)3.10182309
9Congenital stationary night blindness (HP:0007642)3.08873528
10Retrobulbar optic neuritis (HP:0100654)3.03396414
11Optic neuritis (HP:0100653)3.03396414
12Hepatocellular necrosis (HP:0001404)3.02819566
13Abnormality of the renal medulla (HP:0100957)2.91653742
14Tubular atrophy (HP:0000092)2.91650737
15Stomatitis (HP:0010280)2.88023272
16Neonatal respiratory distress (HP:0002643)2.86703526
17Cutaneous melanoma (HP:0012056)2.84856393
18Nephronophthisis (HP:0000090)2.82253515
19Pancreatic fibrosis (HP:0100732)2.81803667
20Mitochondrial inheritance (HP:0001427)2.81199590
21Chronic hepatic failure (HP:0100626)2.79891297
22Decreased electroretinogram (ERG) amplitude (HP:0000654)2.75168562
23Amyotrophic lateral sclerosis (HP:0007354)2.72929782
243-Methylglutaconic aciduria (HP:0003535)2.70199605
25Hepatic necrosis (HP:0002605)2.69873053
26Supernumerary spleens (HP:0009799)2.68820948
27Progressive inability to walk (HP:0002505)2.68569576
28Aplastic anemia (HP:0001915)2.66718361
29Encephalitis (HP:0002383)2.66484262
30Abnormality of midbrain morphology (HP:0002418)2.65559998
31Molar tooth sign on MRI (HP:0002419)2.65559998
32Increased IgM level (HP:0003496)2.63079961
33Bile duct proliferation (HP:0001408)2.63029126
34Abnormal biliary tract physiology (HP:0012439)2.63029126
35Congenital, generalized hypertrichosis (HP:0004540)2.58308639
36Dry hair (HP:0011359)2.57765048
37Thyroiditis (HP:0100646)2.57576922
38Increased CSF lactate (HP:0002490)2.57038710
39Retinal dysplasia (HP:0007973)2.52634015
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.51534816
41Abnormality of T cells (HP:0002843)2.50288915
42Cerebral hypomyelination (HP:0006808)2.49562576
43Severe combined immunodeficiency (HP:0004430)2.49430831
44Abnormal drinking behavior (HP:0030082)2.47953720
45Polydipsia (HP:0001959)2.47953720
46Abnormality of lateral ventricle (HP:0030047)2.46094830
47Abnormality of T cell physiology (HP:0011840)2.44603980
48Abnormal mitochondria in muscle tissue (HP:0008316)2.44079677
49Acute encephalopathy (HP:0006846)2.42652430
50Renal cortical cysts (HP:0000803)2.41015212
51Keratoconjunctivitis (HP:0001096)2.40567847
52Tubulointerstitial fibrosis (HP:0005576)2.39965881
53Pancreatic islet-cell hyperplasia (HP:0004510)2.39727425
54Acute necrotizing encephalopathy (HP:0006965)2.38523332
55Abnormality of B cell number (HP:0010975)2.37694037
56IgG deficiency (HP:0004315)2.35047146
57T lymphocytopenia (HP:0005403)2.29247570
58Orchitis (HP:0100796)2.29136586
59Menstrual irregularities (HP:0000858)2.28756844
60Abnormality of T cell number (HP:0011839)2.28007113
61Keratoconjunctivitis sicca (HP:0001097)2.25054648
62Polyneuropathy (HP:0001271)2.22887901
63Recurrent fungal infections (HP:0002841)2.21097520
64Agammaglobulinemia (HP:0004432)2.18430524
65Dyschromatopsia (HP:0007641)2.17178724
66Attenuation of retinal blood vessels (HP:0007843)2.12816893
67Cystic liver disease (HP:0006706)2.12679572
68Combined immunodeficiency (HP:0005387)2.10103558
69Chronic mucocutaneous candidiasis (HP:0002728)2.09299567
70Recurrent cutaneous fungal infections (HP:0011370)2.09299567
71Congenital hepatic fibrosis (HP:0002612)2.09238368
72Tachypnea (HP:0002789)2.08618668
73Chronic bronchitis (HP:0004469)2.07782571
74Type I transferrin isoform profile (HP:0003642)2.07699418
75Myositis (HP:0100614)2.06646245
76Inability to walk (HP:0002540)2.05574724
77Increased serum lactate (HP:0002151)2.04507017
78Keratitis (HP:0000491)2.02976922
79Emotional lability (HP:0000712)2.00786963
80Cheilitis (HP:0100825)2.00716986
81Progressive macrocephaly (HP:0004481)1.98440538
82Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97886283
83Dicarboxylic aciduria (HP:0003215)1.97886283
84B lymphocytopenia (HP:0010976)1.97769023
85Hyperglycinemia (HP:0002154)1.94256064
86Alopecia of scalp (HP:0002293)1.92889321
87Polyuria (HP:0000103)1.91705488
88Eosinophilia (HP:0001880)1.91218301
89Optic disc pallor (HP:0000543)1.91188505
90Hyperglycinuria (HP:0003108)1.89866273
91Lethargy (HP:0001254)1.87518780
92Decreased central vision (HP:0007663)1.86198761
93Abnormality of secondary sexual hair (HP:0009888)1.85538028
94Abnormality of the axillary hair (HP:0100134)1.85538028
95True hermaphroditism (HP:0010459)1.85174480
96CNS demyelination (HP:0007305)1.84899489
97Testicular atrophy (HP:0000029)1.83648375
98Autoimmune thrombocytopenia (HP:0001973)1.82768981
99Pancytopenia (HP:0001876)1.78670700
100Potter facies (HP:0002009)1.77943323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.75862605
2NEK93.55951027
3BMPR1B3.42997864
4BCKDK3.31285035
5TAOK32.98853063
6BCR2.96114309
7MST42.83754502
8EIF2AK32.36165489
9MAP3K132.05099735
10WNK41.97689704
11MAP3K121.92087064
12GRK11.88786595
13NUAK11.87725996
14KDR1.82340098
15CDK81.74863640
16TGFBR11.71164618
17STK161.69927254
18MAP3K141.69329234
19MAP4K21.67455827
20TIE11.65576627
21CSNK1A1L1.63305389
22KIT1.62356611
23FRK1.55732361
24CSNK1G31.49728610
25SRPK11.48122893
26ITK1.47563656
27MAPKAPK31.45309416
28FLT31.40993217
29ADRBK21.35310257
30TRIM281.34007471
31WNK31.33768458
32TGFBR21.29940514
33CSNK1G21.18836388
34MAPK131.16516073
35BUB11.13318599
36TAOK11.12924047
37EIF2AK21.12468595
38VRK21.08161801
39NME11.06475632
40OXSR11.04973282
41ZAK1.04833453
42DYRK21.04077184
43PLK21.03755440
44LMTK21.03655348
45WEE11.02631727
46CSNK1G10.99153446
47STK390.95765243
48JAK30.92268859
49DAPK10.91128179
50IKBKB0.90617016
51CAMKK20.90235067
52LATS10.89501440
53MET0.89384080
54PBK0.88705704
55LIMK10.85186682
56TEC0.82742505
57SYK0.81597001
58TLK10.81222862
59NEK10.77548133
60GRK70.75556244
61PIK3CA0.75142350
62PLK30.74773460
63PRKCQ0.69145875
64EIF2AK10.69040275
65PTK2B0.67090956
66STK100.65760438
67CSF1R0.63225411
68AKT30.61965164
69CSNK1A10.60719230
70CHUK0.60525008
71FES0.60072256
72WNK10.59015760
73MAP4K10.58215196
74NEK60.58061492
75MYLK0.56480811
76DAPK20.55620921
77MAP3K70.55607759
78BTK0.55595114
79LYN0.53588257
80MKNK10.51099822
81GRK50.50338893
82HIPK20.49074260
83VRK10.48144878
84PDK20.47171398
85ACVR1B0.45949722
86INSRR0.40540492
87ERBB30.39054327
88IGF1R0.37755461
89CLK10.37710632
90PLK10.37249214
91PRKCE0.34275320
92BLK0.31854926
93ABL20.30470900
94ATR0.30129806
95BRSK20.28701394
96MAPK110.28567830
97ADRBK10.27776638
98RPS6KA50.27142012
99LCK0.26103746
100CAMK2A0.25586354

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.37721472
2Proteasome_Homo sapiens_hsa030503.77690151
3Allograft rejection_Homo sapiens_hsa053303.44338009
4Antigen processing and presentation_Homo sapiens_hsa046123.43725980
5Asthma_Homo sapiens_hsa053103.16443030
6Graft-versus-host disease_Homo sapiens_hsa053323.08306079
7Autoimmune thyroid disease_Homo sapiens_hsa053203.01201826
8Primary immunodeficiency_Homo sapiens_hsa053402.61314068
9Type I diabetes mellitus_Homo sapiens_hsa049402.44583804
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.42019508
11Rheumatoid arthritis_Homo sapiens_hsa053232.32870429
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26748997
13Propanoate metabolism_Homo sapiens_hsa006402.04892199
14Oxidative phosphorylation_Homo sapiens_hsa001902.03864543
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03397678
16Nitrogen metabolism_Homo sapiens_hsa009101.60725545
17RNA polymerase_Homo sapiens_hsa030201.55909798
18Parkinsons disease_Homo sapiens_hsa050121.47839170
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41755268
20Viral myocarditis_Homo sapiens_hsa054161.38484287
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.35532554
22Glutathione metabolism_Homo sapiens_hsa004801.34075949
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25295540
24Tryptophan metabolism_Homo sapiens_hsa003801.24022549
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23762815
26Staphylococcus aureus infection_Homo sapiens_hsa051501.16963625
27Regulation of autophagy_Homo sapiens_hsa041401.16650996
28Hematopoietic cell lineage_Homo sapiens_hsa046401.15785383
29Alzheimers disease_Homo sapiens_hsa050101.13896637
30Nucleotide excision repair_Homo sapiens_hsa034201.13156262
31Systemic lupus erythematosus_Homo sapiens_hsa053221.10638793
32Malaria_Homo sapiens_hsa051441.10038322
33Caffeine metabolism_Homo sapiens_hsa002321.08641226
34Basal transcription factors_Homo sapiens_hsa030221.06891592
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04263520
36One carbon pool by folate_Homo sapiens_hsa006701.03238651
37Phototransduction_Homo sapiens_hsa047441.02709871
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99304515
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95852424
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94729107
41Linoleic acid metabolism_Homo sapiens_hsa005910.91794355
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90524059
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.90117206
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87492452
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85797423
46Huntingtons disease_Homo sapiens_hsa050160.85507286
47Leishmaniasis_Homo sapiens_hsa051400.84780106
48Arachidonic acid metabolism_Homo sapiens_hsa005900.81185661
49Purine metabolism_Homo sapiens_hsa002300.81076791
50RNA degradation_Homo sapiens_hsa030180.80537198
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79109661
52Fatty acid elongation_Homo sapiens_hsa000620.78007914
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77418504
54Mismatch repair_Homo sapiens_hsa034300.77197192
55Mineral absorption_Homo sapiens_hsa049780.76979288
56beta-Alanine metabolism_Homo sapiens_hsa004100.76170577
57Chemical carcinogenesis_Homo sapiens_hsa052040.74733470
58Butanoate metabolism_Homo sapiens_hsa006500.74187095
59Peroxisome_Homo sapiens_hsa041460.67984875
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67748508
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67198522
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65809359
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64786252
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62119069
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61363375
66Homologous recombination_Homo sapiens_hsa034400.58843632
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.57858024
68RNA transport_Homo sapiens_hsa030130.57565623
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57436305
70Epstein-Barr virus infection_Homo sapiens_hsa051690.57022788
71Fanconi anemia pathway_Homo sapiens_hsa034600.56905853
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56212335
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56073832
74Legionellosis_Homo sapiens_hsa051340.56020971
75Herpes simplex infection_Homo sapiens_hsa051680.53123303
76T cell receptor signaling pathway_Homo sapiens_hsa046600.52977281
77Pyrimidine metabolism_Homo sapiens_hsa002400.51850015
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.51133271
79DNA replication_Homo sapiens_hsa030300.50030453
80Cardiac muscle contraction_Homo sapiens_hsa042600.48056859
81Retinol metabolism_Homo sapiens_hsa008300.47973647
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46956522
83Fatty acid metabolism_Homo sapiens_hsa012120.42864306
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42431638
85N-Glycan biosynthesis_Homo sapiens_hsa005100.41994566
86Tyrosine metabolism_Homo sapiens_hsa003500.41876499
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41375297
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40591727
89Tuberculosis_Homo sapiens_hsa051520.40457295
90Fatty acid degradation_Homo sapiens_hsa000710.40292057
91African trypanosomiasis_Homo sapiens_hsa051430.37653967
92Metabolic pathways_Homo sapiens_hsa011000.36987796
93Fat digestion and absorption_Homo sapiens_hsa049750.36480535
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35893412
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.35500375
96TGF-beta signaling pathway_Homo sapiens_hsa043500.34451391
97Measles_Homo sapiens_hsa051620.34056577
98Steroid biosynthesis_Homo sapiens_hsa001000.33767736
99Vitamin digestion and absorption_Homo sapiens_hsa049770.32405514
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29287178

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