SDCCAG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.33889145
2fusion of sperm to egg plasma membrane (GO:0007342)5.65901119
3acrosome assembly (GO:0001675)5.53755919
4DNA unwinding involved in DNA replication (GO:0006268)5.51741945
5cell wall macromolecule catabolic process (GO:0016998)5.42443902
6cell wall macromolecule metabolic process (GO:0044036)5.42443902
7acrosome reaction (GO:0007340)5.37902400
8nuclear pore complex assembly (GO:0051292)5.20295485
9mitotic chromosome condensation (GO:0007076)5.04740379
10regulation of translational fidelity (GO:0006450)4.97244781
11sperm-egg recognition (GO:0035036)4.77572183
12negative regulation of inclusion body assembly (GO:0090084)4.73757501
13ribosomal small subunit biogenesis (GO:0042274)4.57996066
14nuclear pore organization (GO:0006999)4.51983325
15plasma membrane fusion (GO:0045026)4.51918732
16cell-cell recognition (GO:0009988)4.41730920
17heterochromatin organization (GO:0070828)4.36513462
18formation of translation preinitiation complex (GO:0001731)4.28410573
19binding of sperm to zona pellucida (GO:0007339)4.24902666
20sodium ion export (GO:0071436)4.13152291
21multicellular organism reproduction (GO:0032504)4.08414033
22spermatid development (GO:0007286)4.03652443
23nerve growth factor signaling pathway (GO:0038180)3.99668834
24locomotory exploration behavior (GO:0035641)3.98594148
25organic cation transport (GO:0015695)3.97447218
26negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.96618900
27DNA strand elongation involved in DNA replication (GO:0006271)3.92061838
28reproduction (GO:0000003)3.89802327
29protein complex localization (GO:0031503)3.89382205
30proline biosynthetic process (GO:0006561)3.86919571
31response to pheromone (GO:0019236)3.86763799
32calcium ion-dependent exocytosis (GO:0017156)3.85829517
33DNA strand elongation (GO:0022616)3.82243982
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.78718295
35regulation of mammary gland epithelial cell proliferation (GO:0033599)3.78350981
36regulation of translational termination (GO:0006449)3.76865883
37pore complex assembly (GO:0046931)3.76034756
38DNA replication initiation (GO:0006270)3.75322820
39mitotic sister chromatid segregation (GO:0000070)3.72167766
40synaptic vesicle maturation (GO:0016188)3.71618362
41spliceosomal tri-snRNP complex assembly (GO:0000244)3.69268338
42cellular protein complex localization (GO:0034629)3.67786643
43synaptonemal complex assembly (GO:0007130)3.65944243
44macroautophagy (GO:0016236)3.57390821
45synaptonemal complex organization (GO:0070193)3.56193958
46cilium or flagellum-dependent cell motility (GO:0001539)3.54473095
47cellular potassium ion homeostasis (GO:0030007)3.52635640
48mitotic sister chromatid cohesion (GO:0007064)3.51147547
49sister chromatid segregation (GO:0000819)3.50996686
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.49805913
51protein localization to chromosome, centromeric region (GO:0071459)3.47412437
52peptidyl-lysine dimethylation (GO:0018027)3.46823195
53regulation of ARF protein signal transduction (GO:0032012)3.46647579
54regulation of chromatin binding (GO:0035561)3.41185650
55ribonucleoprotein complex biogenesis (GO:0022613)3.40356681
56chromosome condensation (GO:0030261)3.39864540
57mitotic nuclear envelope disassembly (GO:0007077)3.37638467
58response to nerve growth factor (GO:1990089)3.34467738
59cellular response to nerve growth factor stimulus (GO:1990090)3.34467738
60cell communication by electrical coupling (GO:0010644)3.30030930
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28523007
62negative regulation of cell killing (GO:0031342)3.28523007
63mitotic metaphase plate congression (GO:0007080)3.28493212
64RNA stabilization (GO:0043489)3.28130467
65mRNA stabilization (GO:0048255)3.28130467
66regulation of short-term neuronal synaptic plasticity (GO:0048172)3.27242399
67negative regulation of mRNA metabolic process (GO:1903312)3.24685381
68sexual reproduction (GO:0019953)3.24661357
69ribosome biogenesis (GO:0042254)3.24196392
70negative regulation of mRNA processing (GO:0050686)3.24077726
71motile cilium assembly (GO:0044458)3.23643029
72maturation of SSU-rRNA (GO:0030490)3.23347067
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.22066940
74membrane disassembly (GO:0030397)3.19734799
75nuclear envelope disassembly (GO:0051081)3.19734799
76viral transcription (GO:0019083)3.17189378
77DNA duplex unwinding (GO:0032508)3.17092376
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15570221
79nucleobase-containing small molecule interconversion (GO:0015949)3.15244243
80peptidyl-arginine omega-N-methylation (GO:0035247)3.15077315
81COPI coating of Golgi vesicle (GO:0048205)3.14421265
82Golgi transport vesicle coating (GO:0048200)3.14421265
83regulation of ARF GTPase activity (GO:0032312)3.13395330
84DNA topological change (GO:0006265)3.13347572
85regulation of inclusion body assembly (GO:0090083)3.10850059
86telomere maintenance via semi-conservative replication (GO:0032201)3.09367897
87protein export from nucleus (GO:0006611)3.05940820
88folic acid metabolic process (GO:0046655)3.05607988
89folic acid-containing compound biosynthetic process (GO:0009396)3.04639685
90ribosomal large subunit biogenesis (GO:0042273)3.03935051
91translational termination (GO:0006415)3.01827023
92layer formation in cerebral cortex (GO:0021819)3.01225854
93regulation of RNA export from nucleus (GO:0046831)2.99982707
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99781673
95ribosome assembly (GO:0042255)2.99582539
96protein localization to kinetochore (GO:0034501)2.98636531
97synaptic vesicle docking involved in exocytosis (GO:0016081)2.98422142
98regulation of mitotic spindle organization (GO:0060236)2.97304192
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96578358
100regulation of histone H3-K27 methylation (GO:0061085)2.96391638
101negative regulation of RNA splicing (GO:0033119)2.95644243
102establishment of integrated proviral latency (GO:0075713)2.95258655
103DNA geometric change (GO:0032392)2.94939739
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.94642349
105DNA packaging (GO:0006323)2.93931572
106DNA conformation change (GO:0071103)2.92500844
107rRNA transcription (GO:0009303)2.90891061
108spermatogenesis (GO:0007283)2.90265762
109membrane depolarization during action potential (GO:0086010)2.89054799
110L-serine metabolic process (GO:0006563)2.88905718
111male gamete generation (GO:0048232)2.88464077
112signal complex assembly (GO:0007172)2.88271932
113establishment of nucleus localization (GO:0040023)2.87735473
114dicarboxylic acid biosynthetic process (GO:0043650)2.85040389
115negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84578130
116regulation of clathrin-mediated endocytosis (GO:2000369)2.84342383
117cellular sodium ion homeostasis (GO:0006883)2.83474002
118ribosomal small subunit assembly (GO:0000028)2.82169415
119DNA replication checkpoint (GO:0000076)2.81864186
120regulation of NFAT protein import into nucleus (GO:0051532)2.81681241
121regulation of translational elongation (GO:0006448)2.81161929
122positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.80357890
123regulation of cilium movement (GO:0003352)2.79927287
124clathrin coat assembly (GO:0048268)2.79042557
125nuclear envelope organization (GO:0006998)2.77793390
126viral mRNA export from host cell nucleus (GO:0046784)2.77329919
127protein-DNA complex disassembly (GO:0032986)2.77129749
128nucleosome disassembly (GO:0006337)2.77129749
129apoptotic process involved in morphogenesis (GO:0060561)2.76615557
130chromatin assembly (GO:0031497)2.75640843
131regulation of synapse structural plasticity (GO:0051823)2.75242551
132histone arginine methylation (GO:0034969)2.75091459
133positive regulation of DNA-dependent DNA replication (GO:2000105)2.74616329
134negative regulation of cell size (GO:0045792)2.74612103
135single fertilization (GO:0007338)2.74559846
136translational elongation (GO:0006414)2.74451140
137translational initiation (GO:0006413)2.71794130
138piRNA metabolic process (GO:0034587)2.70928725
139regulation of spindle organization (GO:0090224)2.70373868
1403-UTR-mediated mRNA stabilization (GO:0070935)2.69871661
141axonemal dynein complex assembly (GO:0070286)2.69473180
142potassium ion import (GO:0010107)2.69420707
143male meiosis (GO:0007140)2.68876586
144maternal placenta development (GO:0001893)2.68254376
145regulation of nucleobase-containing compound transport (GO:0032239)2.67474785
146pentose-phosphate shunt (GO:0006098)2.67444203
147ionotropic glutamate receptor signaling pathway (GO:0035235)2.66825706
148DNA synthesis involved in DNA repair (GO:0000731)2.66465512
149positive regulation of chromosome segregation (GO:0051984)2.65512004
150proline metabolic process (GO:0006560)2.65186559
151regulation of dendritic spine morphogenesis (GO:0061001)2.65182622
152activation of Rac GTPase activity (GO:0032863)2.65177357
153maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65166106
154microtubule severing (GO:0051013)2.64165643
155epithelial cilium movement (GO:0003351)2.63569550
156protein localization to endosome (GO:0036010)2.62339352
157protein retention in ER lumen (GO:0006621)2.60730163
158glial cell proliferation (GO:0014009)2.59676755
159cell recognition (GO:0008037)2.59606362
160ncRNA 3-end processing (GO:0043628)2.59327382
161regulation of neuronal synaptic plasticity (GO:0048168)2.59000551
162focal adhesion assembly (GO:0048041)2.58295211
163cell-substrate adherens junction assembly (GO:0007045)2.58295211
164synaptic vesicle exocytosis (GO:0016079)2.57811235
165gamete generation (GO:0007276)2.57169109
166IMP biosynthetic process (GO:0006188)2.55495961
167adherens junction assembly (GO:0034333)2.53160637
168regulation of early endosome to late endosome transport (GO:2000641)2.52886793
169regulation of long-term neuronal synaptic plasticity (GO:0048169)2.52593888
170peptidyl-arginine methylation (GO:0018216)2.52121733
171peptidyl-arginine N-methylation (GO:0035246)2.52121733
172fertilization (GO:0009566)2.51774503
173telomere maintenance via recombination (GO:0000722)2.51033257
174germ cell development (GO:0007281)2.50512238
175positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.50240953
176carnitine transport (GO:0015879)2.49698473
177amino-acid betaine transport (GO:0015838)2.49698473
178cellular response to electrical stimulus (GO:0071257)2.48209534
179viral life cycle (GO:0019058)2.47971004
180cellular process involved in reproduction in multicellular organism (GO:0022412)2.46780645
181vesicle transport along microtubule (GO:0047496)2.45668846
182protein maturation by protein folding (GO:0022417)2.45334124
183histone H2B ubiquitination (GO:0033523)2.45206497
184regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.43961749
185ventricular system development (GO:0021591)2.43941677
186glutamate secretion (GO:0014047)2.42509331
187regulation of synaptic vesicle exocytosis (GO:2000300)2.42302987
188positive regulation of histone deacetylation (GO:0031065)2.41657553
189sperm capacitation (GO:0048240)2.40119717
190pre-miRNA processing (GO:0031054)2.38540161
191activation of protein kinase A activity (GO:0034199)2.38064789
192positive regulation of synapse maturation (GO:0090129)2.37085222
193exploration behavior (GO:0035640)2.34084712
194neuromuscular process controlling balance (GO:0050885)2.31876039
195gamma-aminobutyric acid transport (GO:0015812)2.30352283
196calcium ion import (GO:0070509)2.29538621
197regulation of cilium assembly (GO:1902017)2.29204869
198actin filament capping (GO:0051693)2.29003098
199chromatin silencing (GO:0006342)2.28671728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.51398245
2EZH2_22144423_ChIP-Seq_EOC_Human4.70870575
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.60149363
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.45088545
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32908431
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98944564
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.91361156
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.54233363
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48804301
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47715076
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41290511
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.33442877
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32277604
14KDM2B_26808549_Chip-Seq_DND41_Human2.31988026
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29401339
16* MYC_22102868_ChIP-Seq_BL_Human2.14675932
17TCF7_22412390_ChIP-Seq_EML_Mouse2.13734368
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13714510
19LXR_22292898_ChIP-Seq_THP-1_Human2.13504253
20XRN2_22483619_ChIP-Seq_HELA_Human2.10406586
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08465180
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06825048
23DROSHA_22980978_ChIP-Seq_HELA_Human2.00854697
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00711230
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.98890240
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96509839
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.92803851
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.92730129
29* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.90644717
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.90201261
31AR_21909140_ChIP-Seq_LNCAP_Human1.87787128
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85421906
33* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82255600
34KDM2B_26808549_Chip-Seq_K562_Human1.78643532
35GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.78573985
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76073078
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72212858
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71444698
39REST_21632747_ChIP-Seq_MESCs_Mouse1.69614479
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69481716
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66843370
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66343490
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.65067630
44* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64220534
45* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.63705486
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60759904
47DCP1A_22483619_ChIP-Seq_HELA_Human1.60472115
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.57394036
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56537449
50SMC4_20622854_ChIP-Seq_HELA_Human1.55790289
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53973012
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49297711
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49173255
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.48618274
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47044418
56TTF2_22483619_ChIP-Seq_HELA_Human1.46086250
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46009373
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40761393
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40290900
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39965045
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38840960
62* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38087719
63UTX_26944678_Chip-Seq_JUKART_Human1.37331692
64KDM5A_27292631_Chip-Seq_BREAST_Human1.36903853
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36437883
66RUNX_20019798_ChIP-Seq_JUKART_Human1.36318453
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35352501
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35281298
69FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35221808
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34053626
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.33452714
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.32873424
73TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.32538926
74* GABP_19822575_ChIP-Seq_HepG2_Human1.32065135
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31437000
76ZNF263_19887448_ChIP-Seq_K562_Human1.30571586
77* SPI1_23127762_ChIP-Seq_K562_Human1.30194013
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30087038
79WDR5_24793694_ChIP-Seq_LNCAP_Human1.30005459
80P68_20966046_ChIP-Seq_HELA_Human1.28860046
81VDR_21846776_ChIP-Seq_THP-1_Human1.27446203
82STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26810832
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26551028
84CTCF_27219007_Chip-Seq_Bcells_Human1.25790557
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.25193961
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24557226
87DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24162653
88ATF3_27146783_Chip-Seq_COLON_Human1.24082360
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23709808
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23211802
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22790784
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22591494
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22554628
94MAF_26560356_Chip-Seq_TH1_Human1.22412592
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.21673955
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21500676
97TET1_21451524_ChIP-Seq_MESCs_Mouse1.20931168
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20598504
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20433263
100CIITA_25753668_ChIP-Seq_RAJI_Human1.20258743
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18832732
102ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16100809
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15936016
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.15730002
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15595314
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.14954697
107YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14788992
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14539330
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14251044
110NCOR1_26117541_ChIP-Seq_K562_Human1.13931925
111KLF4_19829295_ChIP-Seq_ESCs_Human1.13923257
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13862385
113CREB1_26743006_Chip-Seq_LNCaP_Human1.12983561
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12961778
115CLOCK_20551151_ChIP-Seq_293T_Human1.12751510
116* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12373089
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12116505
118BCOR_27268052_Chip-Seq_Bcells_Human1.11971992
119CHD1_26751641_Chip-Seq_LNCaP_Human1.11187926
120* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09849737
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09395942
122PHF8_20622854_ChIP-Seq_HELA_Human1.09128226
123* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08933011
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08536121
125ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08397638
126SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08051997
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07328531
128GATA1_19941826_ChIP-Seq_K562_Human1.07206910
129TFEB_21752829_ChIP-Seq_HELA_Human1.06734750
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06442638
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06146481
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06023758
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05940413
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03805440
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03209121
136TET1_21490601_ChIP-Seq_MESCs_Mouse1.02130929
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01930306
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01900515
139MYB_26560356_Chip-Seq_TH2_Human1.01880690
140CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01784464
141ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01372448
142E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01299757
143SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01022687
144ZNF274_21170338_ChIP-Seq_K562_Hela1.00210985
145SA1_27219007_Chip-Seq_Bcells_Human0.99854735
146NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99711772
147RACK7_27058665_Chip-Seq_MCF-7_Human0.99609539
148YY1_21170310_ChIP-Seq_MESCs_Mouse0.99504427
149OCT4_19829295_ChIP-Seq_ESCs_Human0.99286256
150SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99016951
151GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.98963095
152CTCF_20526341_ChIP-Seq_ESCs_Human0.98893925
153TP63_22573176_ChIP-Seq_HFKS_Human0.98487167
154RUNX1_27514584_Chip-Seq_MCF-7_Human0.98419460
155UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98227217
156P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97225153
157TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97082590
158SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96163444
159MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96036402
160SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95386710
161VDR_24763502_ChIP-Seq_THP-1_Human0.94936963
162FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94847142
163TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94797912
164* BCL6_27268052_Chip-Seq_Bcells_Human0.94294271
165FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93206797
166KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92052109
167EZH2_27294783_Chip-Seq_ESCs_Mouse0.91907890
168CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91646102
169MYC_27129775_Chip-Seq_CORNEA_Mouse0.91457696
170ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91305320
171GATA1_26923725_Chip-Seq_HPCs_Mouse0.90873929
172SPI1_20517297_ChIP-Seq_HL60_Human0.90614585
173CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89365049
174WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89191505
175MAF_26560356_Chip-Seq_TH2_Human0.88600924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.73336480
2MP0004859_abnormal_synaptic_plasticity6.07169968
3MP0003111_abnormal_nucleus_morphology3.60180496
4MP0003693_abnormal_embryo_hatching3.51725399
5MP0004957_abnormal_blastocyst_morpholog3.13909559
6MP0010234_abnormal_vibrissa_follicle3.11043349
7MP0010094_abnormal_chromosome_stability3.05075131
8MP0003077_abnormal_cell_cycle2.77840928
9MP0003698_abnormal_male_reproductive2.70598132
10MP0003635_abnormal_synaptic_transmissio2.63154145
11MP0000569_abnormal_digit_pigmentation2.56872797
12MP0005670_abnormal_white_adipose2.54109417
13MP0008057_abnormal_DNA_replication2.53173411
14MP0002909_abnormal_adrenal_gland2.46493106
15MP0001730_embryonic_growth_arrest2.42320856
16MP0008961_abnormal_basal_metabolism2.41582559
17MP0005451_abnormal_body_composition2.27073680
18MP0003329_amyloid_beta_deposits2.19437327
19MP0000537_abnormal_urethra_morphology2.18916413
20MP0000350_abnormal_cell_proliferation2.13964592
21MP0001929_abnormal_gametogenesis2.12430861
22MP0008932_abnormal_embryonic_tissue2.11541548
23MP0003303_peritoneal_inflammation2.08626579
24MP0003705_abnormal_hypodermis_morpholog2.03432867
25MP0008007_abnormal_cellular_replicative1.98570127
26MP0002396_abnormal_hematopoietic_system1.80957598
27MP0002063_abnormal_learning/memory/cond1.80851649
28MP0004270_analgesia1.78651145
29MP0005380_embryogenesis_phenotype1.76220228
30MP0001672_abnormal_embryogenesis/_devel1.76220228
31MP0008569_lethality_at_weaning1.71985383
32MP0005083_abnormal_biliary_tract1.69011830
33MP0010307_abnormal_tumor_latency1.67091247
34MP0002653_abnormal_ependyma_morphology1.65102099
35MP0003984_embryonic_growth_retardation1.64872817
36MP0004510_myositis1.63368024
37MP0002080_prenatal_lethality1.62466826
38MP0001849_ear_inflammation1.60465697
39MP0008058_abnormal_DNA_repair1.60338978
40MP0002088_abnormal_embryonic_growth/wei1.57279159
41MP0004858_abnormal_nervous_system1.55754603
42MP0005501_abnormal_skin_physiology1.55335135
43MP0009046_muscle_twitch1.55006073
44MP0001697_abnormal_embryo_size1.54915724
45MP0009745_abnormal_behavioral_response1.54622042
46MP0001765_abnormal_ion_homeostasis1.52413708
47MP0002161_abnormal_fertility/fecundity1.50971771
48MP0003566_abnormal_cell_adhesion1.50178002
49MP0000678_abnormal_parathyroid_gland1.49680399
50MP0001661_extended_life_span1.49393484
51MP0010030_abnormal_orbit_morphology1.48257492
52MP0002796_impaired_skin_barrier1.47549552
53MP0004808_abnormal_hematopoietic_stem1.46858718
54MP0009053_abnormal_anal_canal1.46534399
55MP0003300_gastrointestinal_ulcer1.46434912
56MP0002086_abnormal_extraembryonic_tissu1.45189194
57MP0003075_altered_response_to1.45009210
58MP0002064_seizures1.44571283
59MP0008260_abnormal_autophagy1.42833949
60MP0003172_abnormal_lysosome_physiology1.42643978
61MP0002085_abnormal_embryonic_tissue1.39372360
62MP0004130_abnormal_muscle_cell1.38481716
63MP0004811_abnormal_neuron_physiology1.35693168
64MP0000313_abnormal_cell_death1.35282577
65MP0003633_abnormal_nervous_system1.31930412
66MP0008438_abnormal_cutaneous_collagen1.31532639
67MP0000604_amyloidosis1.30610784
68MP0003453_abnormal_keratinocyte_physiol1.30596345
69MP0002234_abnormal_pharynx_morphology1.29423596
70MP0001348_abnormal_lacrimal_gland1.28670636
71MP0002735_abnormal_chemical_nociception1.28435697
72MP0005666_abnormal_adipose_tissue1.28316173
73MP0000733_abnormal_muscle_development1.26228704
74MP0003045_fibrosis1.23847457
75MP0002084_abnormal_developmental_patter1.23513759
76MP0001984_abnormal_olfaction1.20863157
77MP0005623_abnormal_meninges_morphology1.20629482
78MP0009697_abnormal_copulation1.18417772
79MP0000490_abnormal_crypts_of1.18098163
80MP0008877_abnormal_DNA_methylation1.17740436
81MP0005257_abnormal_intraocular_pressure1.17725490
82MP0004197_abnormal_fetal_growth/weight/1.17327125
83MP0004233_abnormal_muscle_weight1.17260728
84MP0000858_altered_metastatic_potential1.16292603
85MP0000003_abnormal_adipose_tissue1.15779707
86MP0002060_abnormal_skin_morphology1.15170851
87MP0002249_abnormal_larynx_morphology1.13760436
88MP0004185_abnormal_adipocyte_glucose1.13605364
89MP0003436_decreased_susceptibility_to1.11664156
90MP0003315_abnormal_perineum_morphology1.10299228
91MP0003283_abnormal_digestive_organ1.08754301
92MP0003690_abnormal_glial_cell1.08101547
93MP0003091_abnormal_cell_migration1.07049065
94MP0002009_preneoplasia1.05698067
95MP0002572_abnormal_emotion/affect_behav1.05417406
96MP0009333_abnormal_splenocyte_physiolog1.04670177
97MP0005058_abnormal_lysosome_morphology1.04002064
98MP0000762_abnormal_tongue_morphology1.03969343
99MP0002089_abnormal_postnatal_growth/wei1.03950690
100MP0002697_abnormal_eye_size1.03217236
101MP0005621_abnormal_cell_physiology1.03210269
102MP0001346_abnormal_lacrimal_gland1.02655647
103MP0005375_adipose_tissue_phenotype1.02262874
104MP0009379_abnormal_foot_pigmentation1.02235461
105MP0005076_abnormal_cell_differentiation1.02154918
106MP0003786_premature_aging1.01885067
107MP0002210_abnormal_sex_determination1.01451880
108MP0003631_nervous_system_phenotype1.00485820
109MP0005423_abnormal_somatic_nervous0.98571797
110MP0001915_intracranial_hemorrhage0.95444079
111MP0001968_abnormal_touch/_nociception0.94022698
112MP0003252_abnormal_bile_duct0.93473390
113MP0005384_cellular_phenotype0.91679644
114MP0002928_abnormal_bile_duct0.91115928
115MP0005167_abnormal_blood-brain_barrier0.90964064
116MP0001145_abnormal_male_reproductive0.90706713
117MP0000955_abnormal_spinal_cord0.90485442
118MP0002138_abnormal_hepatobiliary_system0.90067491
119MP0010352_gastrointestinal_tract_polyps0.87963688
120MP0004885_abnormal_endolymph0.87841668
121MP0001216_abnormal_epidermal_layer0.87165504
122MP0005187_abnormal_penis_morphology0.87019607
123MP0000428_abnormal_craniofacial_morphol0.86735024
124MP0002822_catalepsy0.86509411
125MP0004272_abnormal_basement_membrane0.86191575
126MP0003115_abnormal_respiratory_system0.85831697
127MP0003632_abnormal_nervous_system0.85621892
128MP0003123_paternal_imprinting0.85448077
129MP0002019_abnormal_tumor_incidence0.85107573
130MP0002092_abnormal_eye_morphology0.84961528
131MP0000579_abnormal_nail_morphology0.83462967
132MP0003942_abnormal_urinary_system0.83366218
133MP0000566_synostosis0.82675281
134MP0001501_abnormal_sleep_pattern0.82626915
135MP0002098_abnormal_vibrissa_morphology0.81726140
136MP0009278_abnormal_bone_marrow0.80584534
137MP0002272_abnormal_nervous_system0.79777635
138MP0002111_abnormal_tail_morphology0.79655268
139MP0010630_abnormal_cardiac_muscle0.78509906
140MP0003221_abnormal_cardiomyocyte_apopto0.77114182
141MP0009840_abnormal_foam_cell0.76727610
142MP0003880_abnormal_central_pattern0.74973383
143MP0002152_abnormal_brain_morphology0.74865429
144MP0005409_darkened_coat_color0.74523986
145MP0000703_abnormal_thymus_morphology0.73978394
146MP0000778_abnormal_nervous_system0.73652970
147MP0009780_abnormal_chondrocyte_physiolo0.72708607
148MP0004264_abnormal_extraembryonic_tissu0.72589996
149MP0008770_decreased_survivor_rate0.70942730
150MP0005535_abnormal_body_temperature0.70820088
151MP0006035_abnormal_mitochondrial_morpho0.70516899
152MP0003385_abnormal_body_wall0.70413269
153MP0009703_decreased_birth_body0.70377902
154MP0004043_abnormal_pH_regulation0.70280271
155MP0002184_abnormal_innervation0.70031265
156MP0002970_abnormal_white_adipose0.68895065
157MP0002066_abnormal_motor_capabilities/c0.68557966
158MP0002877_abnormal_melanocyte_morpholog0.67928612
159MP0002067_abnormal_sensory_capabilities0.67925582
160MP0005023_abnormal_wound_healing0.66796128
161MP0000467_abnormal_esophagus_morphology0.65905247
162MP0000627_abnormal_mammary_gland0.65695062
163MP0001440_abnormal_grooming_behavior0.65502679
164MP0005360_urolithiasis0.64539602
165MP0005166_decreased_susceptibility_to0.63777054
166MP0000653_abnormal_sex_gland0.63233399
167MP0001299_abnormal_eye_distance/0.62810273
168MP0002078_abnormal_glucose_homeostasis0.61776015
169MP0003879_abnormal_hair_cell0.61742974
170MP0002269_muscular_atrophy0.61260230
171MP0000747_muscle_weakness0.60880455
172MP0006082_CNS_inflammation0.59275927
173MP0009672_abnormal_birth_weight0.59204067
174MP0000685_abnormal_immune_system0.59196876
175MP0004087_abnormal_muscle_fiber0.59091507
176MP0002733_abnormal_thermal_nociception0.58441500
177MP0002882_abnormal_neuron_morphology0.58427952
178MP0000358_abnormal_cell_content/0.57166743
179MP0000609_abnormal_liver_physiology0.57154080
180MP0002398_abnormal_bone_marrow0.56294244

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.63674314
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.59230690
3Absent/shortened dynein arms (HP:0200106)4.59230690
4Nasal polyposis (HP:0100582)4.24481185
5Abnormality of the lower motor neuron (HP:0002366)3.72247485
6Abnormality of the nasal mucosa (HP:0000433)3.67708887
7Progressive muscle weakness (HP:0003323)3.44771858
8Hyperacusis (HP:0010780)3.33467196
9Insomnia (HP:0100785)3.16331142
10Chronic bronchitis (HP:0004469)3.12815644
11Visual hallucinations (HP:0002367)3.01946843
12Infertility (HP:0000789)2.97874127
13Myokymia (HP:0002411)2.86604750
14Neoplasm of the heart (HP:0100544)2.81108493
15Progressive external ophthalmoplegia (HP:0000590)2.80926785
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80151519
17Bundle branch block (HP:0011710)2.73339813
18Trismus (HP:0000211)2.70014288
19Abnormal respiratory motile cilium physiology (HP:0012261)2.69887867
20Ulnar bowing (HP:0003031)2.68730403
21Elfin facies (HP:0004428)2.63529057
22Pointed chin (HP:0000307)2.61703244
23Hand muscle atrophy (HP:0009130)2.60590876
24Bronchitis (HP:0012387)2.59727232
25Selective tooth agenesis (HP:0001592)2.58162684
26Postural instability (HP:0002172)2.57492829
27Chromsome breakage (HP:0040012)2.57159277
28Microvesicular hepatic steatosis (HP:0001414)2.56214213
29Supranuclear gaze palsy (HP:0000605)2.54139893
30Global brain atrophy (HP:0002283)2.52462804
31Multiple enchondromatosis (HP:0005701)2.52405863
32Amyotrophic lateral sclerosis (HP:0007354)2.52293407
33Distal upper limb amyotrophy (HP:0007149)2.52270178
34Upper limb amyotrophy (HP:0009129)2.52270178
35Rhinitis (HP:0012384)2.52195020
36Renovascular hypertension (HP:0100817)2.51816258
37Hemiplegia (HP:0002301)2.48524099
38Deviation of the thumb (HP:0009603)2.47527368
39Ragged-red muscle fibers (HP:0003200)2.47490945
40Premature rupture of membranes (HP:0001788)2.44471147
41Impaired smooth pursuit (HP:0007772)2.44420942
42Hemiparesis (HP:0001269)2.42390743
43Reticulocytopenia (HP:0001896)2.39341405
44Increased nuchal translucency (HP:0010880)2.37442425
45Proximal placement of thumb (HP:0009623)2.36904729
46Spastic tetraparesis (HP:0001285)2.36483729
47Macroorchidism (HP:0000053)2.36056359
48Asymmetry of the thorax (HP:0001555)2.35878455
49Focal seizures (HP:0007359)2.35859379
50Vertebral compression fractures (HP:0002953)2.35383979
51Male infertility (HP:0003251)2.34546056
52Broad distal phalanx of finger (HP:0009836)2.30573030
53Disproportionate tall stature (HP:0001519)2.26531004
54Focal motor seizures (HP:0011153)2.25920369
55Heterotopia (HP:0002282)2.25140067
56Protrusio acetabuli (HP:0003179)2.24786702
57Recurrent bronchitis (HP:0002837)2.24334957
58Deep venous thrombosis (HP:0002625)2.20265731
59Cerebral aneurysm (HP:0004944)2.19253160
60Ankyloglossia (HP:0010296)2.18502968
61Lower limb asymmetry (HP:0100559)2.17789841
62Abnormal respiratory motile cilium morphology (HP:0005938)2.17592391
63Abnormal respiratory epithelium morphology (HP:0012253)2.17592391
64Ankle clonus (HP:0011448)2.17022654
65Septate vagina (HP:0001153)2.15767584
66Spinal cord lesions (HP:0100561)2.15462955
67Syringomyelia (HP:0003396)2.15462955
68Depression (HP:0000716)2.14913475
69Overlapping toe (HP:0001845)2.14527686
70Overriding aorta (HP:0002623)2.13224825
71Long palpebral fissure (HP:0000637)2.11937273
72Cerebral inclusion bodies (HP:0100314)2.10679489
73Abnormality of ocular smooth pursuit (HP:0000617)2.09936320
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05512314
75Recurrent otitis media (HP:0000403)2.05361973
76Sparse lateral eyebrow (HP:0005338)2.05285339
77Dysdiadochokinesis (HP:0002075)2.05277166
78Hypomagnesemia (HP:0002917)2.05153346
7911 pairs of ribs (HP:0000878)2.05128025
80Abnormality of the umbilical cord (HP:0010881)2.04393311
81Squamous cell carcinoma (HP:0002860)2.04371182
82Missing ribs (HP:0000921)2.01674388
83Abnormality of magnesium homeostasis (HP:0004921)2.00804903
84Short nail (HP:0001799)1.99914698
85Urethral obstruction (HP:0000796)1.99210980
86Impaired vibration sensation in the lower limbs (HP:0002166)1.98437524
87Urinary urgency (HP:0000012)1.96361190
88Abnormality of the distal phalanges of the toes (HP:0010182)1.96210736
89Dysmetric saccades (HP:0000641)1.92876296
90Abnormality of the calcaneus (HP:0008364)1.92303479
91Abnormality of cells of the erythroid lineage (HP:0012130)1.92074896
92Colitis (HP:0002583)1.91808170
93Long toe (HP:0010511)1.90615550
94Orthostatic hypotension (HP:0001278)1.89823271
95Flat acetabular roof (HP:0003180)1.88833056
96Renal duplication (HP:0000075)1.88328487
97Intention tremor (HP:0002080)1.87613470
98Status epilepticus (HP:0002133)1.86889500
99Abnormal social behavior (HP:0012433)1.86662847
100Impaired social interactions (HP:0000735)1.86662847
101Apathy (HP:0000741)1.86303587
102Biconcave vertebral bodies (HP:0004586)1.86252579
103Patellar dislocation (HP:0002999)1.86123746
104Breast hypoplasia (HP:0003187)1.85532412
105Annular pancreas (HP:0001734)1.85274021
106Abnormality of reticulocytes (HP:0004312)1.85033304
107Papilledema (HP:0001085)1.83417359
108Obsessive-compulsive behavior (HP:0000722)1.83374381
109Abnormality of oral frenula (HP:0000190)1.82317100
110Broad face (HP:0000283)1.81630681
111Dysmetria (HP:0001310)1.81407788
112Abnormal delayed hypersensitivity skin test (HP:0002963)1.81315801
113Distal lower limb amyotrophy (HP:0008944)1.81001699
114Abnormality of the distal phalanx of the thumb (HP:0009617)1.80744597
115Difficulty climbing stairs (HP:0003551)1.80060981
116Abnormal urine output (HP:0012590)1.78951550
117Truncal ataxia (HP:0002078)1.78479114
118Neuronal loss in central nervous system (HP:0002529)1.78151095
119Premature skin wrinkling (HP:0100678)1.77943961
120Premature ovarian failure (HP:0008209)1.76671191
121Lymphangioma (HP:0100764)1.76512769
122Abnormal eating behavior (HP:0100738)1.76410207
123Diminished motivation (HP:0000745)1.76141224
124Atresia of the external auditory canal (HP:0000413)1.75298964
125Shallow orbits (HP:0000586)1.75114192
126Self-mutilation (HP:0000742)1.74747861
127Loss of speech (HP:0002371)1.74456902
128Deep palmar crease (HP:0006191)1.72651838
129Elbow flexion contracture (HP:0002987)1.72592146
130Increased circulating renin level (HP:0000848)1.72463471
131Polyuria (HP:0000103)1.72257676
132Gonadotropin excess (HP:0000837)1.72077870
133Spastic gait (HP:0002064)1.71317279
134Abnormality of cochlea (HP:0000375)1.70188619
135Abnormality of the thoracic spine (HP:0100711)1.69449553
136Bronchiectasis (HP:0002110)1.69438103
137Short 4th metacarpal (HP:0010044)1.68994109
138Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68994109
139Cholecystitis (HP:0001082)1.68988909
140Abnormal gallbladder physiology (HP:0012438)1.68988909
141Abnormality of the phalanges of the hallux (HP:0010057)1.68179660
142Increased connective tissue (HP:0009025)1.67507723
143Progressive hearing impairment (HP:0001730)1.67192468
144Fragile skin (HP:0001030)1.67013865
145Genetic anticipation (HP:0003743)1.66305821
146Back pain (HP:0003418)1.66238140
147Glossoptosis (HP:0000162)1.66173752
148Bowel diverticulosis (HP:0005222)1.66147274
149Bladder diverticulum (HP:0000015)1.65844980
150Abnormal umbilical cord blood vessels (HP:0011403)1.64960998
151Single umbilical artery (HP:0001195)1.64960998
152Abnormality of the fetal cardiovascular system (HP:0010948)1.64960998
153Abnormality of the Achilles tendon (HP:0005109)1.64087567
154Fatigue (HP:0012378)1.64027581
155Abnormality of the 4th metacarpal (HP:0010012)1.64001440
156Achilles tendon contracture (HP:0001771)1.63412605
157Neurofibrillary tangles (HP:0002185)1.63243668
158Flared metaphyses (HP:0003015)1.63243549
159Duplication of thumb phalanx (HP:0009942)1.63231408
160Difficulty running (HP:0009046)1.63142909
161Pseudobulbar signs (HP:0002200)1.62418763
162Arnold-Chiari malformation (HP:0002308)1.62160490
163Abnormality of renal excretion (HP:0011036)1.60928959
164Increased CSF protein (HP:0002922)1.60713311
165Buphthalmos (HP:0000557)1.59650962
166Abnormality of carpal bone ossification (HP:0006257)1.59442373
167Spastic diplegia (HP:0001264)1.59406320
168Reticulocytosis (HP:0001923)1.59308414
169Genu recurvatum (HP:0002816)1.59010434
170Abnormal ossification of hand bones (HP:0005921)1.57822252
171Anosmia (HP:0000458)1.57710860
172Metaphyseal cupping (HP:0003021)1.57700264
173Polycythemia (HP:0001901)1.57486557
174Hyperuricemia (HP:0002149)1.57426839
175Increased purine levels (HP:0004368)1.57426839
176Dislocated radial head (HP:0003083)1.56265440
177Abnormal number of incisors (HP:0011064)1.55687174
178Uterine leiomyosarcoma (HP:0002891)1.54924292
179Leiomyosarcoma (HP:0100243)1.54924292
180Birth length less than 3rd percentile (HP:0003561)1.53952364
181Generalized amyotrophy (HP:0003700)1.52891447
182Advanced eruption of teeth (HP:0006288)1.52641166
183Renal cell carcinoma (HP:0005584)1.52325809
184Ridged nail (HP:0001807)1.52171628
185Truncus arteriosus (HP:0001660)1.52121282
186Delayed cranial suture closure (HP:0000270)1.51279979
187Abnormality of the tricuspid valve (HP:0001702)1.50808481
188Cafe-au-lait spot (HP:0000957)1.50426820
189Natal tooth (HP:0000695)1.50264978
190Microretrognathia (HP:0000308)1.50134886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.97570406
2PRKD33.58380960
3TESK13.49101814
4MAP3K103.16749971
5NME23.09225122
6IRAK33.07853473
7TRIB33.00409878
8PDK32.63876471
9PDK42.63876471
10MAP3K92.37653179
11BUB12.25592919
12EPHA42.22357426
13NTRK32.17299134
14ICK2.14735110
15CAMKK12.06518774
16TAOK12.02047712
17PKN21.96713162
18CDC71.96583319
19STK381.89879486
20CAMKK21.89834394
21SIK11.86523390
22ERN11.84723202
23TAOK21.77156244
24TTK1.76503802
25SIK21.75166791
26MST1R1.66982428
27KSR21.66337240
28RPS6KB21.64003704
29PDK21.61861959
30RIPK41.61463245
31TYRO31.58326906
32PAK61.50784439
33EPHA31.48998892
34CDK71.47915539
35EIF2AK11.43158063
36WNK31.43039555
37SRPK11.39042751
38EPHA21.38972796
39CDK81.34244830
40SCYL21.33350350
41PBK1.30966322
42MAP3K81.29115295
43ALK1.24801318
44PTK2B1.22855417
45PDK11.22794243
46CHEK21.20750963
47KSR11.18684705
48FGFR41.18067356
49DAPK21.17084500
50CDC42BPA1.17010432
51CDK41.16329914
52LATS21.16111837
53EEF2K1.15138252
54PDGFRA1.15115973
55MAP4K11.12987196
56NTRK21.11823828
57TSSK61.09794154
58MARK21.09689321
59ARAF1.09350132
60PDPK11.08451144
61RIPK11.08411929
62PRPF4B1.07016706
63VRK21.05495115
64WNK41.05358195
65WEE11.04691620
66BRAF1.03358422
67PRKCH0.99031569
68CAMK1G0.97100220
69STK110.96478747
70MET0.95642862
71TESK20.94924034
72CHEK10.94864697
73RET0.90525782
74AURKA0.90426274
75WNK10.89920845
76IRAK20.89765100
77MARK10.89579239
78NEK10.86929614
79CDK60.86191729
80CDK190.85093229
81AURKB0.83398476
82TTN0.82347285
83NEK20.81519746
84PAK40.79810042
85BRD40.77873598
86JAK10.76407044
87MAP3K130.76301785
88PTK60.75531249
89MINK10.75272172
90MAP3K10.75134980
91ATR0.74484872
92CDK120.73881202
93STK40.72121859
94MAP3K40.71928840
95ERBB40.70385925
96MAP3K110.69786630
97CDK50.69533784
98ZAP700.69327064
99RPS6KA40.68390595
100MAPK110.68333528
101PLK10.66450397
102MAP2K60.65863239
103PNCK0.65707135
104MAP2K40.65500919
105TAF10.65243865
106PASK0.64229324
107CDK90.63762010
108PDGFRB0.63477900
109DYRK1B0.62724285
110MARK30.62400926
111EPHB20.61650556
112AKT20.60883704
113ILK0.59231498
114PRKD10.58904382
115MTOR0.57983621
116MAP3K20.57543309
117CDK20.56302768
118PRKD20.56275752
119HCK0.56122590
120CLK10.54735583
121IRAK40.53625907
122EPHB10.53357168
123FGFR20.51771331
124DAPK10.51431898
125PAK20.51304144
126CDK10.51277836
127STK100.51031933
128DYRK30.50019995
129MAP2K20.49577054
130PTK20.48713339
131GRK60.47602400
132LATS10.46420369
133RAF10.44765530
134JAK30.43822954
135BRSK10.43177572
136RPS6KC10.43056274
137RPS6KL10.43056274
138MAP3K50.42491430
139MAP2K30.39137775
140PRKCI0.38823799
141LRRK20.38492289
142RPS6KA10.37653278
143CDK150.37593946
144PAK30.37392874
145CDK11A0.37228800
146PRKCG0.36893549
147MAP3K30.36547878
148BRSK20.36400804
149JAK20.36092582
150CSK0.35569565
151RPS6KA20.35127589
152DMPK0.35075387
153BMX0.33316639
154ATM0.33308785
155TNIK0.33029166
156PRKCZ0.32827422
157MELK0.32177287
158FYN0.31482328
159CAMK1D0.31459697
160MAP3K140.31441635
161LMTK20.31428961
162TYK20.31107252
163PLK40.30994134

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.85370386
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71401163
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.45396733
4Ribosome_Homo sapiens_hsa030102.40420061
5Spliceosome_Homo sapiens_hsa030402.39693045
6Cell cycle_Homo sapiens_hsa041102.35644951
7Long-term potentiation_Homo sapiens_hsa047202.34320057
8Base excision repair_Homo sapiens_hsa034102.28771177
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28667765
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28071892
11RNA transport_Homo sapiens_hsa030132.14825422
12Olfactory transduction_Homo sapiens_hsa047402.07646642
13Biosynthesis of amino acids_Homo sapiens_hsa012302.06641989
14Mismatch repair_Homo sapiens_hsa034302.04593141
15One carbon pool by folate_Homo sapiens_hsa006701.92684782
16Sulfur relay system_Homo sapiens_hsa041221.87230930
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.86242121
18Amphetamine addiction_Homo sapiens_hsa050311.83731279
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.76391425
20Nucleotide excision repair_Homo sapiens_hsa034201.69032789
21Glutamatergic synapse_Homo sapiens_hsa047241.63928798
22Bladder cancer_Homo sapiens_hsa052191.63183574
23VEGF signaling pathway_Homo sapiens_hsa043701.62259428
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62038123
25Thyroid cancer_Homo sapiens_hsa052161.61888745
26Nitrogen metabolism_Homo sapiens_hsa009101.61476822
27Circadian entrainment_Homo sapiens_hsa047131.60305293
28Synaptic vesicle cycle_Homo sapiens_hsa047211.56781889
29Type II diabetes mellitus_Homo sapiens_hsa049301.55138880
30Pentose phosphate pathway_Homo sapiens_hsa000301.54611029
31Non-homologous end-joining_Homo sapiens_hsa034501.50817501
32Vitamin B6 metabolism_Homo sapiens_hsa007501.47912153
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47807068
34Insulin secretion_Homo sapiens_hsa049111.47639346
35Pyrimidine metabolism_Homo sapiens_hsa002401.45421265
36Glucagon signaling pathway_Homo sapiens_hsa049221.39870991
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37703615
38Pancreatic cancer_Homo sapiens_hsa052121.34295588
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34080454
40mTOR signaling pathway_Homo sapiens_hsa041501.29300637
41Dopaminergic synapse_Homo sapiens_hsa047281.27625377
42B cell receptor signaling pathway_Homo sapiens_hsa046621.27261367
43Salivary secretion_Homo sapiens_hsa049701.26426792
44Other glycan degradation_Homo sapiens_hsa005111.26284913
45Gastric acid secretion_Homo sapiens_hsa049711.25877297
46Oxytocin signaling pathway_Homo sapiens_hsa049211.25218618
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23136870
48Estrogen signaling pathway_Homo sapiens_hsa049151.22385105
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.19219668
50Thyroid hormone synthesis_Homo sapiens_hsa049181.19108774
51Carbon metabolism_Homo sapiens_hsa012001.18732744
52Fructose and mannose metabolism_Homo sapiens_hsa000511.18392748
53Small cell lung cancer_Homo sapiens_hsa052221.17902845
54T cell receptor signaling pathway_Homo sapiens_hsa046601.16659633
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.16123720
56Adipocytokine signaling pathway_Homo sapiens_hsa049201.15378756
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.12596599
58Renin secretion_Homo sapiens_hsa049241.12566607
59N-Glycan biosynthesis_Homo sapiens_hsa005101.10685831
60Morphine addiction_Homo sapiens_hsa050321.10536576
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09276358
62MicroRNAs in cancer_Homo sapiens_hsa052061.09250644
63Notch signaling pathway_Homo sapiens_hsa043301.08966518
64Fatty acid biosynthesis_Homo sapiens_hsa000611.08933563
65Phospholipase D signaling pathway_Homo sapiens_hsa040721.08024606
66Viral carcinogenesis_Homo sapiens_hsa052031.07370011
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07293743
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06641664
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06396069
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05583173
71Glioma_Homo sapiens_hsa052141.05268683
72Galactose metabolism_Homo sapiens_hsa000521.03577848
73GnRH signaling pathway_Homo sapiens_hsa049121.02136189
74Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02106044
75Bile secretion_Homo sapiens_hsa049761.00874729
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99026954
77Dorso-ventral axis formation_Homo sapiens_hsa043200.98790636
78Nicotine addiction_Homo sapiens_hsa050330.97995735
79GABAergic synapse_Homo sapiens_hsa047270.97848170
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96966476
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95130029
82Osteoclast differentiation_Homo sapiens_hsa043800.93296604
83HTLV-I infection_Homo sapiens_hsa051660.93165085
84Prostate cancer_Homo sapiens_hsa052150.92180756
85Insulin resistance_Homo sapiens_hsa049310.91706151
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91595768
87cAMP signaling pathway_Homo sapiens_hsa040240.91038561
88Arginine biosynthesis_Homo sapiens_hsa002200.89667236
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88472222
90Cholinergic synapse_Homo sapiens_hsa047250.87760507
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87584609
92Endometrial cancer_Homo sapiens_hsa052130.86502551
93Endocytosis_Homo sapiens_hsa041440.86364665
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86055779
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85837932
96Homologous recombination_Homo sapiens_hsa034400.85664014
97Pancreatic secretion_Homo sapiens_hsa049720.85203672
98Renal cell carcinoma_Homo sapiens_hsa052110.84839038
99Cocaine addiction_Homo sapiens_hsa050300.84308650
100Oocyte meiosis_Homo sapiens_hsa041140.83327286
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83051715
102Adherens junction_Homo sapiens_hsa045200.82698057
103Calcium signaling pathway_Homo sapiens_hsa040200.81806712
104p53 signaling pathway_Homo sapiens_hsa041150.81629023
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81075754
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80699292
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79266501
108RNA polymerase_Homo sapiens_hsa030200.78951236
109Choline metabolism in cancer_Homo sapiens_hsa052310.77935250
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76140643
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76040340
112Glycerolipid metabolism_Homo sapiens_hsa005610.75938682
113Lysine degradation_Homo sapiens_hsa003100.75046113
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.74359873
115Epstein-Barr virus infection_Homo sapiens_hsa051690.73601347
116Proteoglycans in cancer_Homo sapiens_hsa052050.73016341
117Selenocompound metabolism_Homo sapiens_hsa004500.71560881
118Insulin signaling pathway_Homo sapiens_hsa049100.70359227
119Non-small cell lung cancer_Homo sapiens_hsa052230.69959841
120Folate biosynthesis_Homo sapiens_hsa007900.68895506
121Apoptosis_Homo sapiens_hsa042100.68793917
122ErbB signaling pathway_Homo sapiens_hsa040120.67587502
123Pyruvate metabolism_Homo sapiens_hsa006200.67527242
124MAPK signaling pathway_Homo sapiens_hsa040100.66983826
125Long-term depression_Homo sapiens_hsa047300.66860864
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66501846
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66220410
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65778442
129Basal transcription factors_Homo sapiens_hsa030220.65576531
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64467624
131Gap junction_Homo sapiens_hsa045400.64231476
132Chemokine signaling pathway_Homo sapiens_hsa040620.62588883
133Fanconi anemia pathway_Homo sapiens_hsa034600.62019295
134Prion diseases_Homo sapiens_hsa050200.61817442
135Chronic myeloid leukemia_Homo sapiens_hsa052200.61757529
136Antigen processing and presentation_Homo sapiens_hsa046120.61182883
137Hepatitis B_Homo sapiens_hsa051610.60472069
138PPAR signaling pathway_Homo sapiens_hsa033200.60232217
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.59884707
140AMPK signaling pathway_Homo sapiens_hsa041520.59261274
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57821943
142Herpes simplex infection_Homo sapiens_hsa051680.56193102
143Axon guidance_Homo sapiens_hsa043600.53399228
144Melanoma_Homo sapiens_hsa052180.52445838
145Colorectal cancer_Homo sapiens_hsa052100.52396536
146Hippo signaling pathway_Homo sapiens_hsa043900.52288530
147Inositol phosphate metabolism_Homo sapiens_hsa005620.52113114
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.51846379
149Toxoplasmosis_Homo sapiens_hsa051450.51799362
150Acute myeloid leukemia_Homo sapiens_hsa052210.51592824
151Basal cell carcinoma_Homo sapiens_hsa052170.51201380
152Shigellosis_Homo sapiens_hsa051310.49503444
153Tuberculosis_Homo sapiens_hsa051520.49225907
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49185297
155Salmonella infection_Homo sapiens_hsa051320.48587749
156HIF-1 signaling pathway_Homo sapiens_hsa040660.48501952
157Leishmaniasis_Homo sapiens_hsa051400.47585586
158mRNA surveillance pathway_Homo sapiens_hsa030150.47475343
159Arginine and proline metabolism_Homo sapiens_hsa003300.47103561
160Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46503800
161Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45946409
162Purine metabolism_Homo sapiens_hsa002300.45930493
163Rap1 signaling pathway_Homo sapiens_hsa040150.45499378
164Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45465268
165Wnt signaling pathway_Homo sapiens_hsa043100.42418913
166Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42364086
167RNA degradation_Homo sapiens_hsa030180.42215084
168Systemic lupus erythematosus_Homo sapiens_hsa053220.41021747

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