SDCCAG8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.58479218
2piRNA metabolic process (GO:0034587)3.87445590
3indole-containing compound catabolic process (GO:0042436)3.64046770
4indolalkylamine catabolic process (GO:0046218)3.64046770
5tryptophan catabolic process (GO:0006569)3.64046770
6L-fucose catabolic process (GO:0042355)3.62287988
7fucose catabolic process (GO:0019317)3.62287988
8L-fucose metabolic process (GO:0042354)3.62287988
9indolalkylamine metabolic process (GO:0006586)3.60086280
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.59997577
11negative regulation of cell killing (GO:0031342)3.53236719
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53236719
13retinal cone cell development (GO:0046549)3.51579407
14presynaptic membrane assembly (GO:0097105)3.50077677
15protein polyglutamylation (GO:0018095)3.48154195
16protein complex biogenesis (GO:0070271)3.47413978
17axoneme assembly (GO:0035082)3.42252119
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37216765
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.37216765
20NADH dehydrogenase complex assembly (GO:0010257)3.37216765
21detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.35453054
22DNA deamination (GO:0045006)3.34669784
23negative regulation of mast cell activation (GO:0033004)3.33672099
24serotonin metabolic process (GO:0042428)3.32639924
25tryptophan metabolic process (GO:0006568)3.30756925
26centriole replication (GO:0007099)3.25140992
27protein localization to cilium (GO:0061512)3.24451962
28histone H3-K4 trimethylation (GO:0080182)3.17911184
29platelet dense granule organization (GO:0060155)3.12396971
30mitochondrial respiratory chain complex assembly (GO:0033108)3.05044077
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04810996
32regulation of B cell receptor signaling pathway (GO:0050855)3.02268374
33DNA methylation involved in gamete generation (GO:0043046)3.02140909
34NIK/NF-kappaB signaling (GO:0038061)3.00802383
35water-soluble vitamin biosynthetic process (GO:0042364)2.99419372
36multicellular organism reproduction (GO:0032504)2.99230926
37energy homeostasis (GO:0097009)2.99014305
38preassembly of GPI anchor in ER membrane (GO:0016254)2.98588714
39ionotropic glutamate receptor signaling pathway (GO:0035235)2.96850056
40G-protein coupled receptor internalization (GO:0002031)2.93502916
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93239537
42neural tube formation (GO:0001841)2.92738757
43regulation of synaptic vesicle transport (GO:1902803)2.92685540
44presynaptic membrane organization (GO:0097090)2.92095869
45dentate gyrus development (GO:0021542)2.91409221
46cellular biogenic amine catabolic process (GO:0042402)2.91297570
47amine catabolic process (GO:0009310)2.91297570
48synaptic vesicle docking involved in exocytosis (GO:0016081)2.89487843
49regulation of synaptic vesicle exocytosis (GO:2000300)2.89166666
50behavioral response to ethanol (GO:0048149)2.88048120
51microglial cell activation (GO:0001774)2.87578019
52negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85761405
53intraciliary transport (GO:0042073)2.84720989
54kynurenine metabolic process (GO:0070189)2.82754534
55negative regulation of appetite (GO:0032099)2.79489177
56negative regulation of response to food (GO:0032096)2.79489177
57regulation of action potential (GO:0098900)2.79335234
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78105332
59gamma-aminobutyric acid signaling pathway (GO:0007214)2.77621249
60regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77212565
61regulation of meiosis I (GO:0060631)2.75197824
62startle response (GO:0001964)2.74739957
63synaptic vesicle endocytosis (GO:0048488)2.74471030
64neuron cell-cell adhesion (GO:0007158)2.72467714
65cilium morphogenesis (GO:0060271)2.72150038
66germinal center formation (GO:0002467)2.71586429
67gamma-aminobutyric acid transport (GO:0015812)2.71277221
68glutamate receptor signaling pathway (GO:0007215)2.68240245
69primary amino compound metabolic process (GO:1901160)2.66308687
70indole-containing compound metabolic process (GO:0042430)2.65563165
71photoreceptor cell development (GO:0042461)2.65260909
72cerebellar Purkinje cell differentiation (GO:0021702)2.65147703
73regulation of glutamate receptor signaling pathway (GO:1900449)2.64773376
74neuronal action potential (GO:0019228)2.63877604
75parturition (GO:0007567)2.63312388
76respiratory chain complex IV assembly (GO:0008535)2.61135696
77tachykinin receptor signaling pathway (GO:0007217)2.60857468
78dopamine transport (GO:0015872)2.60099868
79postsynaptic membrane organization (GO:0001941)2.59979277
80mannosylation (GO:0097502)2.59708818
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57732295
82regulation of female gonad development (GO:2000194)2.56916694
83regulation of germinal center formation (GO:0002634)2.55185389
84regulation of platelet aggregation (GO:0090330)2.54986468
85positive regulation of fatty acid transport (GO:2000193)2.54679336
86aggressive behavior (GO:0002118)2.54429781
87synaptic transmission, glutamatergic (GO:0035249)2.54394269
88cellular ketone body metabolic process (GO:0046950)2.53912441
89positive regulation of prostaglandin secretion (GO:0032308)2.52205070
90cilium movement (GO:0003341)2.51186092
91seminiferous tubule development (GO:0072520)2.50053180
92positive regulation of cellular amide metabolic process (GO:0034250)2.49802759
93positive regulation of protein homodimerization activity (GO:0090073)2.49777920
94regulation of glucokinase activity (GO:0033131)2.48959778
95regulation of hexokinase activity (GO:1903299)2.48959778
96cytochrome complex assembly (GO:0017004)2.48487424
97vocalization behavior (GO:0071625)2.48384356
98aromatic amino acid family catabolic process (GO:0009074)2.47893839
99positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47887140
100synaptic transmission, cholinergic (GO:0007271)2.45671861
101synaptic vesicle exocytosis (GO:0016079)2.45231246
102neuron-neuron synaptic transmission (GO:0007270)2.44163471
103pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.42712982
104pyrimidine nucleobase catabolic process (GO:0006208)2.42388286
105photoreceptor cell maintenance (GO:0045494)2.40536636
106eye photoreceptor cell development (GO:0042462)2.39678479
107cilium or flagellum-dependent cell motility (GO:0001539)2.38981060
108regulation of microtubule-based movement (GO:0060632)2.38184608
109detection of calcium ion (GO:0005513)2.38125805
110establishment of protein localization to Golgi (GO:0072600)2.38044351
111nonmotile primary cilium assembly (GO:0035058)2.38015864
112ubiquinone biosynthetic process (GO:0006744)2.37627514
113male meiosis I (GO:0007141)2.37586813
114neutrophil activation (GO:0042119)2.36538260
115regulation of acrosome reaction (GO:0060046)2.35921597
116GPI anchor metabolic process (GO:0006505)2.34929112
117positive regulation of protein sumoylation (GO:0033235)2.34659140
118protein localization to synapse (GO:0035418)2.34590602
119nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.33845109
120phagosome maturation (GO:0090382)2.33767615
121sperm motility (GO:0030317)2.33748576
122ubiquinone metabolic process (GO:0006743)2.32691832
123positive regulation of meiosis (GO:0045836)2.32180381
124developmental pigmentation (GO:0048066)2.31998789
125ketone body metabolic process (GO:1902224)2.31354088
126neutrophil activation involved in immune response (GO:0002283)2.30930520
127adenosine metabolic process (GO:0046085)2.30831536
128neurotransmitter-gated ion channel clustering (GO:0072578)2.30538178
129regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.30496703
130positive regulation by symbiont of host defense response (GO:0052509)2.30184835
131modulation by symbiont of host defense response (GO:0052031)2.30184835
132modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30184835
133modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30184835
134positive regulation by organism of defense response of other organism involved in symbiotic interact2.30184835
135modulation by symbiont of host immune response (GO:0052553)2.30184835
136epithelial cilium movement (GO:0003351)2.30069096
137neutrophil mediated immunity (GO:0002446)2.29907737
138protein neddylation (GO:0045116)2.29825102
139striatum development (GO:0021756)2.29627624
140response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.29427200
141response to host immune response (GO:0052572)2.29427200
142inositol phosphate catabolic process (GO:0071545)2.29347671
143cilium assembly (GO:0042384)2.28393869
144negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.27901002
145detection of mechanical stimulus involved in sensory perception (GO:0050974)2.27725725
146regulation of excitatory postsynaptic membrane potential (GO:0060079)2.27678349
147regulation of female receptivity (GO:0045924)2.27658752
148cell morphogenesis involved in neuron differentiation (GO:0048667)2.27560669
149detection of light stimulus involved in sensory perception (GO:0050962)2.27365836
150detection of light stimulus involved in visual perception (GO:0050908)2.27365836
151response to pheromone (GO:0019236)2.26898635
152G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.26622931
153base-excision repair, AP site formation (GO:0006285)2.26596041
154negative regulation of homotypic cell-cell adhesion (GO:0034111)2.26320952
155glycerophospholipid catabolic process (GO:0046475)2.26288975
156replication fork processing (GO:0031297)2.26211972
157positive regulation of heat generation (GO:0031652)2.24999730
158membrane depolarization during action potential (GO:0086010)2.24998159
159exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.24669786
160positive regulation of icosanoid secretion (GO:0032305)2.24151414
161ATP synthesis coupled proton transport (GO:0015986)2.23742530
162membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.23440856
163long-term synaptic potentiation (GO:0060291)2.23202043
164regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.22910693
165T cell migration (GO:0072678)2.22230288
166cilium organization (GO:0044782)2.21179969
167macrophage activation involved in immune response (GO:0002281)2.20360807
168regulation of postsynaptic membrane potential (GO:0060078)2.19024300
169regulation of neurotransmitter secretion (GO:0046928)2.18950195
170vesicle docking (GO:0048278)2.18834560
171motile cilium assembly (GO:0044458)2.18691921
172positive regulation of monocyte chemotaxis (GO:0090026)2.18196965
173vesicle docking involved in exocytosis (GO:0006904)2.17734099
174phosphorelay signal transduction system (GO:0000160)2.16837302
175dendritic cell migration (GO:0036336)2.15407734
176purinergic nucleotide receptor signaling pathway (GO:0035590)2.15338623
177regulation of synaptic transmission, glutamatergic (GO:0051966)2.15129657
178superoxide anion generation (GO:0042554)2.14860628
179regulation of cilium movement (GO:0003352)2.14784422
180cellular response to interleukin-15 (GO:0071350)2.14203831
181termination of G-protein coupled receptor signaling pathway (GO:0038032)2.13493044
182negative regulation of interleukin-17 production (GO:0032700)2.12248489
183regulation of pigment cell differentiation (GO:0050932)2.11850151
184epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.11380597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.14178191
2EZH2_22144423_ChIP-Seq_EOC_Human3.50933301
3ZNF274_21170338_ChIP-Seq_K562_Hela3.05237252
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.88719352
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.67207384
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48422744
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41002655
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39554541
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07474784
10TAF15_26573619_Chip-Seq_HEK293_Human2.03454394
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99683382
12* EWS_26573619_Chip-Seq_HEK293_Human1.98227905
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90221358
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90094378
15P300_19829295_ChIP-Seq_ESCs_Human1.88721117
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86187616
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85271503
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83860655
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83312296
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80441080
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.79504631
22SMAD4_21799915_ChIP-Seq_A2780_Human1.79428457
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77060251
24DROSHA_22980978_ChIP-Seq_HELA_Human1.73165404
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72204257
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71833174
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69404928
28CBP_20019798_ChIP-Seq_JUKART_Human1.69404928
29IGF1R_20145208_ChIP-Seq_DFB_Human1.68539269
30* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68198190
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67697548
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.66593156
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66421103
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66146954
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65121686
36* NANOG_18555785_Chip-Seq_ESCs_Mouse1.62632174
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.61710629
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.60375738
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59794984
40* BCAT_22108803_ChIP-Seq_LS180_Human1.56111928
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55905094
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55420620
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55184730
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.54884110
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54591093
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53922307
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51501764
48* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50745601
49ER_23166858_ChIP-Seq_MCF-7_Human1.48079922
50* TP53_22573176_ChIP-Seq_HFKS_Human1.47460728
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46916489
52TCF4_23295773_ChIP-Seq_U87_Human1.46171523
53* E2F1_18555785_Chip-Seq_ESCs_Mouse1.45837396
54* P53_22387025_ChIP-Seq_ESCs_Mouse1.44007356
55REST_21632747_ChIP-Seq_MESCs_Mouse1.43516969
56* STAT3_23295773_ChIP-Seq_U87_Human1.43022492
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42602875
58* CMYC_18555785_Chip-Seq_ESCs_Mouse1.41891660
59* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39848529
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39347678
61IRF1_19129219_ChIP-ChIP_H3396_Human1.39136356
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38596654
63* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38056579
64AR_21572438_ChIP-Seq_LNCaP_Human1.37541318
65* IRF8_27001747_Chip-Seq_BMDM_Mouse1.37397909
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36750821
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36750821
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.35789414
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33862457
70VDR_22108803_ChIP-Seq_LS180_Human1.33033775
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33006970
72* NFE2_27457419_Chip-Seq_LIVER_Mouse1.32581380
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.32392550
74* STAT3_18555785_Chip-Seq_ESCs_Mouse1.32002023
75* SMAD3_21741376_ChIP-Seq_EPCs_Human1.31566486
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29559241
77FUS_26573619_Chip-Seq_HEK293_Human1.28741326
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27605853
79NANOG_19829295_ChIP-Seq_ESCs_Human1.27497619
80SOX2_19829295_ChIP-Seq_ESCs_Human1.27497619
81* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27151374
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25865190
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.25705930
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25256328
85JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25190097
86* EZH2_27294783_Chip-Seq_NPCs_Mouse1.25079000
87* P300_18555785_Chip-Seq_ESCs_Mouse1.25069466
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24131925
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.24131925
90* SOX2_18555785_Chip-Seq_ESCs_Mouse1.24062064
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.23414435
92* TCF4_22108803_ChIP-Seq_LS180_Human1.23307724
93AR_25329375_ChIP-Seq_VCAP_Human1.23068587
94* PRDM14_20953172_ChIP-Seq_ESCs_Human1.22013801
95* NMYC_18555785_Chip-Seq_ESCs_Mouse1.21405774
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21280145
97* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21253251
98* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20652498
99RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20280217
100EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20280217
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20008321
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.19435976
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19074245
104KDM2B_26808549_Chip-Seq_REH_Human1.18992729
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18290269
106ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17955262
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17822612
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17193799
109RNF2_27304074_Chip-Seq_ESCs_Mouse1.15887477
110* PU1_27457419_Chip-Seq_LIVER_Mouse1.15653844
111* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14199720
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14068521
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13583028
114* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13548147
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13354390
116AR_20517297_ChIP-Seq_VCAP_Human1.13070958
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12871286
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.12455096
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11851793
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.11372635
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11315584
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10986886
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10775172
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.10722504
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10550550
126* TP53_18474530_ChIP-ChIP_U2OS_Human1.10371822
127RUNX2_22187159_ChIP-Seq_PCA_Human1.10317186
128ARNT_22903824_ChIP-Seq_MCF-7_Human1.09809809
129* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09429772
130* OCT4_18555785_Chip-Seq_ESCs_Mouse1.08889843
131RNF2_27304074_Chip-Seq_NSC_Mouse1.08846021
132SALL1_21062744_ChIP-ChIP_HESCs_Human1.07445918
133NCOR_22424771_ChIP-Seq_293T_Human1.07214582
134EZH2_27294783_Chip-Seq_ESCs_Mouse1.06770433
135GABP_17652178_ChIP-ChIP_JURKAT_Human1.06371278
136* CRX_20693478_ChIP-Seq_RETINA_Mouse1.06219348
137MYC_18940864_ChIP-ChIP_HL60_Human1.04395165
138CDX2_22108803_ChIP-Seq_LS180_Human1.01129650
139TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98646113
140* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97482110
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97032046
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96544976
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92799572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.75062240
2MP0000569_abnormal_digit_pigmentation3.72721949
3MP0002138_abnormal_hepatobiliary_system3.20300507
4MP0001835_abnormal_antigen_presentation2.83272356
5MP0003195_calcinosis2.82433008
6MP0004859_abnormal_synaptic_plasticity2.67507019
7MP0001188_hyperpigmentation2.42233760
8MP0005645_abnormal_hypothalamus_physiol2.36804821
9MP0001986_abnormal_taste_sensitivity2.30090044
10MP0002837_dystrophic_cardiac_calcinosis2.27193197
11MP0005379_endocrine/exocrine_gland_phen2.22565960
12MP0003787_abnormal_imprinting2.17744339
13MP0000015_abnormal_ear_pigmentation2.17167973
14MP0003880_abnormal_central_pattern2.12058189
15MP0001984_abnormal_olfaction2.11833854
16MP0005646_abnormal_pituitary_gland2.11455866
17MP0004142_abnormal_muscle_tone2.02830638
18MP0002653_abnormal_ependyma_morphology1.98883050
19MP0009745_abnormal_behavioral_response1.96559312
20MP0003635_abnormal_synaptic_transmissio1.92601577
21MP0004885_abnormal_endolymph1.91271358
22MP0002928_abnormal_bile_duct1.89746798
23MP0002163_abnormal_gland_morphology1.88711694
24MP0005387_immune_system_phenotype1.86936665
25MP0001790_abnormal_immune_system1.86936665
26MP0002735_abnormal_chemical_nociception1.86264789
27MP0002736_abnormal_nociception_after1.86164887
28MP0005671_abnormal_response_to1.85797435
29MP0005310_abnormal_salivary_gland1.85187715
30MP0002572_abnormal_emotion/affect_behav1.83671429
31MP0005174_abnormal_tail_pigmentation1.80201992
32MP0001968_abnormal_touch/_nociception1.76318545
33MP0004043_abnormal_pH_regulation1.74102752
34MP0002277_abnormal_respiratory_mucosa1.73145603
35MP0002064_seizures1.66801010
36MP0004510_myositis1.66119930
37MP0005409_darkened_coat_color1.65165946
38MP0002063_abnormal_learning/memory/cond1.64242160
39MP0002148_abnormal_hypersensitivity_rea1.62530284
40MP0001486_abnormal_startle_reflex1.61687064
41MP0005171_absent_coat_pigmentation1.61203855
42MP0009046_muscle_twitch1.59439921
43MP0000372_irregular_coat_pigmentation1.58226350
44MP0005084_abnormal_gallbladder_morpholo1.57555149
45MP0003172_abnormal_lysosome_physiology1.57325116
46MP0008872_abnormal_physiological_respon1.57173459
47MP0001501_abnormal_sleep_pattern1.54492133
48MP0000685_abnormal_immune_system1.48380615
49MP0003718_maternal_effect1.47900439
50MP0000631_abnormal_neuroendocrine_gland1.46717625
51MP0002272_abnormal_nervous_system1.44024318
52MP0002876_abnormal_thyroid_physiology1.41269097
53MP0010386_abnormal_urinary_bladder1.41000391
54MP0003646_muscle_fatigue1.40725557
55MP0003121_genomic_imprinting1.38182219
56MP0002067_abnormal_sensory_capabilities1.37554742
57MP0002419_abnormal_innate_immunity1.36773742
58MP0005551_abnormal_eye_electrophysiolog1.36596947
59MP0004145_abnormal_muscle_electrophysio1.35537971
60MP0005075_abnormal_melanosome_morpholog1.34766133
61MP0005000_abnormal_immune_tolerance1.33536558
62MP0001800_abnormal_humoral_immune1.33214721
63MP0001485_abnormal_pinna_reflex1.32537624
64MP0003011_delayed_dark_adaptation1.29141080
65MP0001502_abnormal_circadian_rhythm1.28850783
66MP0002452_abnormal_antigen_presenting1.27808160
67MP0003252_abnormal_bile_duct1.25552021
68MP0001440_abnormal_grooming_behavior1.23730151
69MP0002638_abnormal_pupillary_reflex1.22300771
70MP0002160_abnormal_reproductive_system1.22296340
71MP0002723_abnormal_immune_serum1.20542776
72MP0004133_heterotaxia1.20129778
73MP0001348_abnormal_lacrimal_gland1.19256308
74MP0008789_abnormal_olfactory_epithelium1.19074187
75MP0000427_abnormal_hair_cycle1.18691713
76MP0008875_abnormal_xenobiotic_pharmacok1.17996404
77MP0005389_reproductive_system_phenotype1.16616058
78MP0004147_increased_porphyrin_level1.14137343
79MP0004270_analgesia1.13980634
80MP0002693_abnormal_pancreas_physiology1.13369123
81MP0008877_abnormal_DNA_methylation1.12425488
82MP0004742_abnormal_vestibular_system1.11737185
83MP0001529_abnormal_vocalization1.11211086
84MP0002420_abnormal_adaptive_immunity1.11041456
85MP0001819_abnormal_immune_cell1.10158821
86MP0005670_abnormal_white_adipose1.09785844
87MP0003136_yellow_coat_color1.09381955
88MP0003045_fibrosis1.09358855
89MP0005386_behavior/neurological_phenoty1.08762154
90MP0004924_abnormal_behavior1.08762154
91MP0002557_abnormal_social/conspecific_i1.08558420
92MP0002938_white_spotting1.08223016
93MP0001970_abnormal_pain_threshold1.05632163
94MP0002234_abnormal_pharynx_morphology1.04221015
95MP0005360_urolithiasis1.03139918
96MP0005025_abnormal_response_to1.02961969
97MP0008775_abnormal_heart_ventricle1.02921068
98MP0002734_abnormal_mechanical_nocicepti1.02720262
99MP0002909_abnormal_adrenal_gland1.02064201
100MP0005423_abnormal_somatic_nervous1.01841051
101MP0000230_abnormal_systemic_arterial1.01462147
102MP0005195_abnormal_posterior_eye0.96230861
103MP0002229_neurodegeneration0.96037907
104MP0005410_abnormal_fertilization0.95202895
105MP0002102_abnormal_ear_morphology0.94961397
106MP0002998_abnormal_bone_remodeling0.94650114
107MP0006072_abnormal_retinal_apoptosis0.93835916
108MP0006292_abnormal_olfactory_placode0.93291888
109MP0000383_abnormal_hair_follicle0.92511519
110MP0009785_altered_susceptibility_to0.92267415
111MP0006276_abnormal_autonomic_nervous0.91410137
112MP0002733_abnormal_thermal_nociception0.91116646
113MP0008995_early_reproductive_senescence0.90967698
114MP0003879_abnormal_hair_cell0.89863435
115MP0005253_abnormal_eye_physiology0.88394220
116MP0003436_decreased_susceptibility_to0.85836444
117MP0005167_abnormal_blood-brain_barrier0.84560648
118MP0005085_abnormal_gallbladder_physiolo0.84456220
119MP0002752_abnormal_somatic_nervous0.84143042
120MP0002095_abnormal_skin_pigmentation0.83075744
121MP0009764_decreased_sensitivity_to0.82642510
122MP0001963_abnormal_hearing_physiology0.82246660
123MP0001756_abnormal_urination0.81816402
124MP0004215_abnormal_myocardial_fiber0.81757124
125MP0000013_abnormal_adipose_tissue0.81416222
126MP0001324_abnormal_eye_pigmentation0.80634410
127MP0009780_abnormal_chondrocyte_physiolo0.80211672
128MP0008569_lethality_at_weaning0.79915986
129MP0002405_respiratory_system_inflammati0.78831427
130MP0002166_altered_tumor_susceptibility0.78441928
131MP0001929_abnormal_gametogenesis0.78031282
132MP0001764_abnormal_homeostasis0.77888041
133MP0009697_abnormal_copulation0.77727830
134MP0001905_abnormal_dopamine_level0.77606371
135MP0005394_taste/olfaction_phenotype0.77209709
136MP0005499_abnormal_olfactory_system0.77209709
137MP0009379_abnormal_foot_pigmentation0.75355991
138MP0001919_abnormal_reproductive_system0.74833080
139MP0002184_abnormal_innervation0.74765498
140MP0000778_abnormal_nervous_system0.72121829
141MP0003633_abnormal_nervous_system0.71087018
142MP0001177_atelectasis0.69277624
143MP0001186_pigmentation_phenotype0.69051645
144MP0002882_abnormal_neuron_morphology0.69035317
145MP0000716_abnormal_immune_system0.68625996
146MP0005058_abnormal_lysosome_morphology0.68152420
147MP0005257_abnormal_intraocular_pressure0.67058395
148MP0004811_abnormal_neuron_physiology0.66004835
149MP0003690_abnormal_glial_cell0.64672640
150MP0003763_abnormal_thymus_physiology0.64564826
151MP0001873_stomach_inflammation0.64192439

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.62276756
2Febrile seizures (HP:0002373)4.41745339
3Decreased circulating renin level (HP:0003351)4.16101718
4Abnormality of the renal cortex (HP:0011035)3.71314255
5Abnormal hair whorl (HP:0010721)3.57129417
6Epileptic encephalopathy (HP:0200134)3.56362128
7Recurrent abscess formation (HP:0002722)3.49001238
8Type II lissencephaly (HP:0007260)3.47257067
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.32224358
10Absent/shortened dynein arms (HP:0200106)3.32224358
11Nephrogenic diabetes insipidus (HP:0009806)3.24928221
12Renal cortical cysts (HP:0000803)3.21988203
13Hip dysplasia (HP:0001385)3.17491767
14Abolished electroretinogram (ERG) (HP:0000550)3.08591201
15Hypothermia (HP:0002045)3.03405432
16* Medial flaring of the eyebrow (HP:0010747)3.01390216
17Abnormal ciliary motility (HP:0012262)3.00587443
18Hyperactive renin-angiotensin system (HP:0000841)2.92568776
19Recurrent bacterial skin infections (HP:0005406)2.91636966
20Gait imbalance (HP:0002141)2.79688295
21Hypokalemic alkalosis (HP:0001949)2.78942063
22Hyperkalemia (HP:0002153)2.78197988
23Congenital stationary night blindness (HP:0007642)2.77097476
24Congenital primary aphakia (HP:0007707)2.76851139
25Attenuation of retinal blood vessels (HP:0007843)2.75832701
26Acute necrotizing encephalopathy (HP:0006965)2.75591087
27Protruding tongue (HP:0010808)2.74173820
28Chronic bronchitis (HP:0004469)2.72680393
29Hyperventilation (HP:0002883)2.71960563
30Abnormal respiratory motile cilium physiology (HP:0012261)2.66953881
31Tubulointerstitial nephritis (HP:0001970)2.66405675
32Prostate neoplasm (HP:0100787)2.64219102
33Abnormal drinking behavior (HP:0030082)2.63183951
34Polydipsia (HP:0001959)2.63183951
35Progressive macrocephaly (HP:0004481)2.61666840
363-Methylglutaconic aciduria (HP:0003535)2.59931560
37Cerebellar dysplasia (HP:0007033)2.59640345
38Chronic mucocutaneous candidiasis (HP:0002728)2.59501610
39Recurrent cutaneous fungal infections (HP:0011370)2.59501610
40Mitochondrial inheritance (HP:0001427)2.58670559
41Drooling (HP:0002307)2.52473373
42Excessive salivation (HP:0003781)2.52473373
43Tubular atrophy (HP:0000092)2.50629913
44Chronic diarrhea (HP:0002028)2.49994283
45Increased CSF lactate (HP:0002490)2.48365787
46Atonic seizures (HP:0010819)2.45743974
47Abnormality of the right ventricle (HP:0001707)2.44945151
48Widely spaced teeth (HP:0000687)2.43424116
49Sclerocornea (HP:0000647)2.39521044
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.39247826
51Hyperaldosteronism (HP:0000859)2.38792902
52Hepatic necrosis (HP:0002605)2.37046435
53Acute encephalopathy (HP:0006846)2.36267461
54Pancreatic fibrosis (HP:0100732)2.33853504
55Abnormal mitochondria in muscle tissue (HP:0008316)2.33100071
56Chronic hepatic failure (HP:0100626)2.33006874
57True hermaphroditism (HP:0010459)2.31176359
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.30935621
59Pachygyria (HP:0001302)2.28123708
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27944738
61Focal seizures (HP:0007359)2.27356919
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25225080
63J-shaped sella turcica (HP:0002680)2.25211970
64Retinal dysplasia (HP:0007973)2.22347741
65Congenital, generalized hypertrichosis (HP:0004540)2.21128942
66Recurrent fungal infections (HP:0002841)2.20662606
67Thyroiditis (HP:0100646)2.19572618
68Progressive cerebellar ataxia (HP:0002073)2.19502743
69Metabolic alkalosis (HP:0200114)2.19494933
70Eczematoid dermatitis (HP:0000976)2.19090216
71Hepatocellular necrosis (HP:0001404)2.18368180
72Bile duct proliferation (HP:0001408)2.16729719
73Abnormal biliary tract physiology (HP:0012439)2.16729719
74Polyuria (HP:0000103)2.14219835
75Optic disc pallor (HP:0000543)2.13604876
76Abnormal respiratory motile cilium morphology (HP:0005938)2.11724181
77Abnormal respiratory epithelium morphology (HP:0012253)2.11724181
78Lissencephaly (HP:0001339)2.09300218
79Conjugated hyperbilirubinemia (HP:0002908)2.09087008
80Poor coordination (HP:0002370)2.08064482
81Median cleft lip (HP:0000161)2.07255068
82Anencephaly (HP:0002323)2.07248450
83Furrowed tongue (HP:0000221)2.04585716
84Male pseudohermaphroditism (HP:0000037)2.02109096
85Metaphyseal dysplasia (HP:0100255)2.01559746
86Gingivitis (HP:0000230)2.00331081
87Recurrent skin infections (HP:0001581)2.00063273
88Polyphagia (HP:0002591)1.99890430
89Absent eyebrow (HP:0002223)1.99791092
90Optic nerve hypoplasia (HP:0000609)1.98131910
91Optic neuritis (HP:0100653)1.97015922
92Retrobulbar optic neuritis (HP:0100654)1.97015922
93Vaginal atresia (HP:0000148)1.95683265
94Genital tract atresia (HP:0001827)1.95554424
95Absence seizures (HP:0002121)1.95150665
96Abnormality of alanine metabolism (HP:0010916)1.93732413
97Hyperalaninemia (HP:0003348)1.93732413
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93732413
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.92965901
100Methylmalonic acidemia (HP:0002912)1.92711759
101Submucous cleft hard palate (HP:0000176)1.92183404
102Recurrent pneumonia (HP:0006532)1.91773279
103Postaxial foot polydactyly (HP:0001830)1.91581463
104Thyroid-stimulating hormone excess (HP:0002925)1.91034822
105Tubulointerstitial abnormality (HP:0001969)1.90305281
106Retinitis pigmentosa (HP:0000510)1.88599809
107Aplasia/Hypoplasia of the lens (HP:0008063)1.88462676
108* Nephronophthisis (HP:0000090)1.88430076
109Bronchiectasis (HP:0002110)1.86990036
110Generalized hypopigmentation of hair (HP:0011358)1.85158640
111Molar tooth sign on MRI (HP:0002419)1.84878307
112Abnormality of midbrain morphology (HP:0002418)1.84878307
113* Abnormality of the renal medulla (HP:0100957)1.84845758
114Methylmalonic aciduria (HP:0012120)1.84695743
115Abnormality of chloride homeostasis (HP:0011422)1.84660391
116Stomatitis (HP:0010280)1.84570913
117Increased corneal curvature (HP:0100692)1.84360127
118Keratoconus (HP:0000563)1.84360127
119Anal stenosis (HP:0002025)1.84322269
120Renal Fanconi syndrome (HP:0001994)1.84126760
121Lipid accumulation in hepatocytes (HP:0006561)1.83975250
122Pancreatic cysts (HP:0001737)1.82571033
123Bony spicule pigmentary retinopathy (HP:0007737)1.82326978
124Bronchitis (HP:0012387)1.82275880
125Chronic sinusitis (HP:0011109)1.82199339
126Abnormality of macular pigmentation (HP:0008002)1.81747236
127Dialeptic seizures (HP:0011146)1.81616062
128Alveolar cell carcinoma (HP:0006519)1.80958917
129Absent speech (HP:0001344)1.80899389
130Inability to walk (HP:0002540)1.80607433
131Congenital sensorineural hearing impairment (HP:0008527)1.80448010
132Severe muscular hypotonia (HP:0006829)1.80435953
133Gaze-evoked nystagmus (HP:0000640)1.80132447
134Constricted visual fields (HP:0001133)1.79889002
135Abnormality of salivation (HP:0100755)1.79377294
136Dysostosis multiplex (HP:0000943)1.79373749
137Abnormality of polysaccharide metabolism (HP:0011012)1.79109185
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79109185
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79109185
140Fair hair (HP:0002286)1.79028146
141Abnormality of glycolipid metabolism (HP:0010969)1.78328798
142Abnormality of liposaccharide metabolism (HP:0010968)1.78328798
143Abnormality of glycosphingolipid metabolism (HP:0004343)1.78328798
144Myositis (HP:0100614)1.77689122
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77348138
146Agitation (HP:0000713)1.77146695
147Hemiparesis (HP:0001269)1.77112529
148Rhinitis (HP:0012384)1.76990747
149Stomach cancer (HP:0012126)1.76608894
150Obstructive lung disease (HP:0006536)1.76367192
151Chronic obstructive pulmonary disease (HP:0006510)1.76367192
152* Congenital hepatic fibrosis (HP:0002612)1.74480576
153Broad-based gait (HP:0002136)1.73816382
154Abnormality of renin-angiotensin system (HP:0000847)1.73631674
155Decreased central vision (HP:0007663)1.72318545
156Cystic liver disease (HP:0006706)1.72316860
157Glycosuria (HP:0003076)1.71079600
158Abnormality of urine glucose concentration (HP:0011016)1.71079600
159Recurrent gram-negative bacterial infections (HP:0005420)1.70797082
160Abnormal delayed hypersensitivity skin test (HP:0002963)1.70347774
161Tubulointerstitial fibrosis (HP:0005576)1.70276699
162Pendular nystagmus (HP:0012043)1.70084527
163Popliteal pterygium (HP:0009756)1.68366870
164Abnormal rod and cone electroretinograms (HP:0008323)1.67053658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.99139537
2RIPK43.60194577
3MAP3K142.80240476
4NTRK32.52967254
5PINK12.52110111
6SIK22.40127793
7IRAK42.24693996
8ACVR1B2.23352427
9GRK12.17246924
10TXK2.16504255
11MAP4K22.14699854
12INSRR2.09703754
13BMPR22.05855168
14MAP3K132.05084787
15GRK72.04956518
16SIK32.02456424
17IRAK31.91524009
18WNK31.82221922
19YES11.77425172
20TNIK1.68170995
21WNK41.66951403
22MAP2K71.65365775
23PRPF4B1.60523622
24FRK1.60438243
25TAOK31.54470414
26PLK21.53814816
27TLK11.52288786
28TGFBR11.51832111
29BCKDK1.50913391
30BLK1.49657556
31CAMK1G1.42250962
32JAK11.40846630
33LMTK21.40018702
34MAP3K21.35144157
35PNCK1.32696931
36BMPR1B1.32393443
37ADRBK21.29350631
38NUAK11.29239797
39CAMK1D1.23237749
40IRAK11.19094483
41SGK21.18460220
42EIF2AK21.17235742
43CDK81.16418451
44FES1.16333719
45MAP3K41.14082701
46MAP3K121.13848840
47CDK31.13080367
48SYK1.12452396
49CAMKK21.12368447
50PAK31.11195870
51FLT31.07515594
52NEK61.07064692
53MARK11.07017286
54EPHA41.06227647
55JAK31.05899829
56ADRBK11.03525867
57GRK50.99741306
58TYK20.99126323
59STK390.98022796
60OXSR10.97526003
61KIT0.97475304
62DYRK20.97444370
63ERBB30.96803981
64MST40.94563365
65PHKG10.93182675
66PHKG20.93182675
67NLK0.92778988
68EPHA30.92744986
69MAP3K30.92296442
70CSNK1G20.90311618
71TRIM280.89235222
72PRKCQ0.84743525
73TGFBR20.84596892
74TIE10.81435819
75MAP4K10.81069828
76PRKCE0.79820974
77CSNK1G30.77935187
78LYN0.77568479
79IKBKE0.76153866
80MAPK150.74161542
81MAPKAPK30.73927503
82CSNK1G10.73379287
83TNK20.72528436
84DAPK10.72340619
85DAPK20.71975824
86FGR0.71940076
87SGK30.71901339
88TEC0.71067237
89CDK90.70807615
90IKBKB0.70558125
91LCK0.70214202
92MAPK130.67833359
93PIK3CA0.67515244
94STK30.66944097
95HIPK20.66216142
96SGK10.64745604
97MAPK70.63428767
98CHUK0.61838034
99CAMK10.61641710
100SGK4940.61103985
101SGK2230.61103985
102AKT30.59779193
103HCK0.59216251
104PTK2B0.59030880
105NTRK20.58734696
106CDK50.55636667
107STK38L0.55293840
108PRKACA0.55090552
109ZAK0.54611361
110CAMK2A0.53135032
111MUSK0.52882653
112CSF1R0.52696298
113EIF2AK30.52536886
114STK110.52466739
115OBSCN0.52215986
116CSNK1A1L0.50604123
117NEK90.50397995
118PKN10.50394062
119MKNK20.49662613
120MARK30.48405688
121MAP2K60.47787483
122MARK20.45549594
123PIK3CG0.42756640
124CSNK1A10.42731945
125TRPM70.41993310
126MAPKAPK50.41840354
127PRKG10.41685281
128RPS6KA50.40461844
129WNK10.40180214
130IRAK20.39880354
131PRKCA0.39294081
132CCNB10.38913523
133STK160.37545029
134CAMK2D0.37213494
135BCR0.36275577
136CDK120.35139326
137PRKCH0.34806519
138ABL10.34043013
139ITK0.33720695
140MAPK100.33688247
141TBK10.33462792
142VRK20.33108180
143PRKCI0.32863755
144DYRK1A0.32795318
145TAF10.32594844
146VRK10.32336036
147FER0.32186259
148PRKACB0.31450291
149CAMK2B0.31402877
150PIM10.31396115
151PRKCG0.31376726

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.94549803
2Nicotine addiction_Homo sapiens_hsa050332.68077564
3Parkinsons disease_Homo sapiens_hsa050122.26409559
4Linoleic acid metabolism_Homo sapiens_hsa005912.12228032
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07261926
6Morphine addiction_Homo sapiens_hsa050321.97020906
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94005846
8Synaptic vesicle cycle_Homo sapiens_hsa047211.92611708
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91805030
10Nitrogen metabolism_Homo sapiens_hsa009101.89192952
11Taste transduction_Homo sapiens_hsa047421.85208749
12Asthma_Homo sapiens_hsa053101.78366702
13Olfactory transduction_Homo sapiens_hsa047401.78230578
14Butanoate metabolism_Homo sapiens_hsa006501.75524357
15Circadian entrainment_Homo sapiens_hsa047131.74719655
16Basal transcription factors_Homo sapiens_hsa030221.70047506
17Homologous recombination_Homo sapiens_hsa034401.69679879
18Collecting duct acid secretion_Homo sapiens_hsa049661.61268554
19Glutamatergic synapse_Homo sapiens_hsa047241.60888503
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59674711
21Long-term potentiation_Homo sapiens_hsa047201.57982955
22Tryptophan metabolism_Homo sapiens_hsa003801.57878500
23Renin secretion_Homo sapiens_hsa049241.56719586
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56392076
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.56073035
26RNA polymerase_Homo sapiens_hsa030201.55433372
27Ether lipid metabolism_Homo sapiens_hsa005651.51475545
28Huntingtons disease_Homo sapiens_hsa050161.49077642
29Insulin secretion_Homo sapiens_hsa049111.48722679
30Amphetamine addiction_Homo sapiens_hsa050311.46329438
31Serotonergic synapse_Homo sapiens_hsa047261.45663412
32GABAergic synapse_Homo sapiens_hsa047271.45639780
33Cardiac muscle contraction_Homo sapiens_hsa042601.45028377
34Alzheimers disease_Homo sapiens_hsa050101.44629273
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.44583604
36Caffeine metabolism_Homo sapiens_hsa002321.43963462
37Osteoclast differentiation_Homo sapiens_hsa043801.43268670
38Rheumatoid arthritis_Homo sapiens_hsa053231.42111462
39Phototransduction_Homo sapiens_hsa047441.41556201
40Fanconi anemia pathway_Homo sapiens_hsa034601.41142601
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40880771
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40700242
43Regulation of autophagy_Homo sapiens_hsa041401.39516737
44Peroxisome_Homo sapiens_hsa041461.36105286
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31557659
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30285519
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28250554
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28122119
49Vibrio cholerae infection_Homo sapiens_hsa051101.26074569
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.25672280
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25303306
52Salivary secretion_Homo sapiens_hsa049701.25044998
53Propanoate metabolism_Homo sapiens_hsa006401.25042238
54Calcium signaling pathway_Homo sapiens_hsa040201.24845514
55Cholinergic synapse_Homo sapiens_hsa047251.19826569
56RNA degradation_Homo sapiens_hsa030181.18318219
57Type I diabetes mellitus_Homo sapiens_hsa049401.18211803
58Dopaminergic synapse_Homo sapiens_hsa047281.17182290
59Phagosome_Homo sapiens_hsa041451.16163272
60Chemical carcinogenesis_Homo sapiens_hsa052041.16039650
61B cell receptor signaling pathway_Homo sapiens_hsa046621.15802843
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12926930
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.12360621
64African trypanosomiasis_Homo sapiens_hsa051431.12243239
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11812460
66Leishmaniasis_Homo sapiens_hsa051401.11608876
67cAMP signaling pathway_Homo sapiens_hsa040241.11480317
68Type II diabetes mellitus_Homo sapiens_hsa049301.10785196
69Measles_Homo sapiens_hsa051621.10610419
70Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10338821
71Arachidonic acid metabolism_Homo sapiens_hsa005901.10097042
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08665506
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07942159
74Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06626453
75Chemokine signaling pathway_Homo sapiens_hsa040621.06617045
76Glycosaminoglycan degradation_Homo sapiens_hsa005311.06313303
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05701307
78Tuberculosis_Homo sapiens_hsa051521.03009110
79Ovarian steroidogenesis_Homo sapiens_hsa049131.02964623
80Cocaine addiction_Homo sapiens_hsa050301.02147609
81Long-term depression_Homo sapiens_hsa047301.01381408
82Primary immunodeficiency_Homo sapiens_hsa053401.00327651
83Dorso-ventral axis formation_Homo sapiens_hsa043201.00312006
84Oxytocin signaling pathway_Homo sapiens_hsa049210.99462412
85Hematopoietic cell lineage_Homo sapiens_hsa046400.98320853
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94299222
87Ribosome_Homo sapiens_hsa030100.94127156
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93588547
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92643523
90T cell receptor signaling pathway_Homo sapiens_hsa046600.91433377
91ABC transporters_Homo sapiens_hsa020100.91395893
92Inositol phosphate metabolism_Homo sapiens_hsa005620.89222880
93Allograft rejection_Homo sapiens_hsa053300.86004440
94Graft-versus-host disease_Homo sapiens_hsa053320.84077397
95Lysosome_Homo sapiens_hsa041420.82976758
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82271583
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82175165
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82163036
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.80668215
100Gastric acid secretion_Homo sapiens_hsa049710.80635207
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80451427
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80429873
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79687085
104Selenocompound metabolism_Homo sapiens_hsa004500.78842780
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77290442
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76651803
107Other glycan degradation_Homo sapiens_hsa005110.75654173
108Retinol metabolism_Homo sapiens_hsa008300.75216024
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74329706
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74071144
111Influenza A_Homo sapiens_hsa051640.73099090
112Autoimmune thyroid disease_Homo sapiens_hsa053200.71918863
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71328707
114Protein export_Homo sapiens_hsa030600.70604382
115TNF signaling pathway_Homo sapiens_hsa046680.70081274
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69736447
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.69349574
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68940986
119Circadian rhythm_Homo sapiens_hsa047100.68885144
120Malaria_Homo sapiens_hsa051440.67272761
121Purine metabolism_Homo sapiens_hsa002300.67171203
122MAPK signaling pathway_Homo sapiens_hsa040100.66997708
123Glycerolipid metabolism_Homo sapiens_hsa005610.66338878
124GnRH signaling pathway_Homo sapiens_hsa049120.62002169
125Axon guidance_Homo sapiens_hsa043600.61373200
126Pertussis_Homo sapiens_hsa051330.60447502
127Sphingolipid metabolism_Homo sapiens_hsa006000.58422920
128Sulfur metabolism_Homo sapiens_hsa009200.58151488
129Toxoplasmosis_Homo sapiens_hsa051450.57240563
130Ras signaling pathway_Homo sapiens_hsa040140.56999853
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.56597010
132Platelet activation_Homo sapiens_hsa046110.56527695
133Metabolic pathways_Homo sapiens_hsa011000.56447532
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56128968
135Hepatitis B_Homo sapiens_hsa051610.55859202
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55599409
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54480747
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53739728
139beta-Alanine metabolism_Homo sapiens_hsa004100.53231255
140Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52955252
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52355030
142Choline metabolism in cancer_Homo sapiens_hsa052310.50237587
143Salmonella infection_Homo sapiens_hsa051320.49932673
144Fatty acid elongation_Homo sapiens_hsa000620.49789374
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49685371
146Antigen processing and presentation_Homo sapiens_hsa046120.48594921
147Pancreatic secretion_Homo sapiens_hsa049720.47538143
148ErbB signaling pathway_Homo sapiens_hsa040120.46897748
149Pancreatic cancer_Homo sapiens_hsa052120.46350390
150Mineral absorption_Homo sapiens_hsa049780.45420597
151Fatty acid degradation_Homo sapiens_hsa000710.44216652
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38107533
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.36304002
154Nucleotide excision repair_Homo sapiens_hsa034200.34387278

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