SDE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.32416347
2maturation of SSU-rRNA (GO:0030490)4.15523596
3regulation of RNA export from nucleus (GO:0046831)3.88121184
4mitotic metaphase plate congression (GO:0007080)3.84614788
5dosage compensation (GO:0007549)3.83848582
6DNA replication initiation (GO:0006270)3.79577298
7formation of translation preinitiation complex (GO:0001731)3.78871090
8nucleobase biosynthetic process (GO:0046112)3.75141244
9mitotic sister chromatid cohesion (GO:0007064)3.74982201
10regulation of DNA endoreduplication (GO:0032875)3.73912339
11nuclear pore organization (GO:0006999)3.71859534
12ribosome assembly (GO:0042255)3.66682925
13nuclear pore complex assembly (GO:0051292)3.65805393
14ribosomal small subunit biogenesis (GO:0042274)3.61736164
15monoubiquitinated protein deubiquitination (GO:0035520)3.60918552
16DNA strand elongation involved in DNA replication (GO:0006271)3.58756126
17ribosome biogenesis (GO:0042254)3.56480280
18ribosomal large subunit biogenesis (GO:0042273)3.53634441
19ribonucleoprotein complex biogenesis (GO:0022613)3.53336108
20peptidyl-threonine dephosphorylation (GO:0035970)3.53060083
21protein localization to kinetochore (GO:0034501)3.48944059
22viral transcription (GO:0019083)3.47929328
23purine nucleobase biosynthetic process (GO:0009113)3.47462033
24translational termination (GO:0006415)3.44941580
25IMP biosynthetic process (GO:0006188)3.44711247
26DNA strand elongation (GO:0022616)3.40229984
27mitotic nuclear envelope disassembly (GO:0007077)3.40148007
28regulation of histone H3-K9 methylation (GO:0051570)3.38753612
29telomere maintenance via semi-conservative replication (GO:0032201)3.38318713
30DNA replication checkpoint (GO:0000076)3.37073924
31rRNA catabolic process (GO:0016075)3.33080598
32metaphase plate congression (GO:0051310)3.31330734
33rRNA processing (GO:0006364)3.26226609
34DNA unwinding involved in DNA replication (GO:0006268)3.26053523
35negative regulation of histone methylation (GO:0031061)3.23949844
36translational initiation (GO:0006413)3.23166017
37CENP-A containing nucleosome assembly (GO:0034080)3.20340145
38positive regulation of histone H3-K4 methylation (GO:0051571)3.18801058
39membrane disassembly (GO:0030397)3.17372576
40nuclear envelope disassembly (GO:0051081)3.17372576
41erythrocyte development (GO:0048821)3.15664537
42chromatin remodeling at centromere (GO:0031055)3.14679187
43definitive hemopoiesis (GO:0060216)3.14504367
44rRNA metabolic process (GO:0016072)3.14215131
45regulation of spindle organization (GO:0090224)3.13113186
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12628364
47telomere maintenance via recombination (GO:0000722)3.11129883
48regulation of histone H3-K4 methylation (GO:0051569)3.11005028
49protoporphyrinogen IX metabolic process (GO:0046501)3.10143891
50rRNA modification (GO:0000154)3.09372906
51mitotic chromosome condensation (GO:0007076)3.06928014
52pore complex assembly (GO:0046931)3.05601509
53DNA replication-dependent nucleosome assembly (GO:0006335)3.02639963
54DNA replication-dependent nucleosome organization (GO:0034723)3.02639963
55positive regulation of granulocyte differentiation (GO:0030854)3.01752188
56translational elongation (GO:0006414)3.01055771
57kinetochore organization (GO:0051383)3.00154731
58establishment of chromosome localization (GO:0051303)2.99987802
59mitotic recombination (GO:0006312)2.99930134
60cytoplasmic mRNA processing body assembly (GO:0033962)2.99726617
61regulation of nuclear cell cycle DNA replication (GO:0033262)2.99637465
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97444339
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97158782
64protein localization to chromosome, centromeric region (GO:0071459)2.96429686
65folic acid-containing compound biosynthetic process (GO:0009396)2.95688472
66DNA replication-independent nucleosome organization (GO:0034724)2.95292290
67DNA replication-independent nucleosome assembly (GO:0006336)2.95292290
68N-terminal protein amino acid acetylation (GO:0006474)2.95084091
69spliceosomal snRNP assembly (GO:0000387)2.94963838
70regulation of histone H3-K27 methylation (GO:0061085)2.92711901
71cotranslational protein targeting to membrane (GO:0006613)2.90424090
72protein targeting to ER (GO:0045047)2.89142015
73mitotic sister chromatid segregation (GO:0000070)2.88392474
74transcription elongation from RNA polymerase I promoter (GO:0006362)2.87972458
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87254611
76somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87196509
77somatic hypermutation of immunoglobulin genes (GO:0016446)2.87196509
78IMP metabolic process (GO:0046040)2.86052600
79transcription elongation from RNA polymerase III promoter (GO:0006385)2.85672893
80termination of RNA polymerase III transcription (GO:0006386)2.85672893
81termination of RNA polymerase I transcription (GO:0006363)2.84293369
82DNA deamination (GO:0045006)2.83901483
83mitotic G2/M transition checkpoint (GO:0044818)2.83379004
84pseudouridine synthesis (GO:0001522)2.82961203
85protein K6-linked ubiquitination (GO:0085020)2.82078161
86regulation of nucleobase-containing compound transport (GO:0032239)2.81479211
87telomere maintenance via telomere lengthening (GO:0010833)2.81426690
88sister chromatid cohesion (GO:0007062)2.81190975
89kinetochore assembly (GO:0051382)2.80942099
90proteasome assembly (GO:0043248)2.78798217
91transcription-coupled nucleotide-excision repair (GO:0006283)2.78478184
92histone H3-K4 trimethylation (GO:0080182)2.78166418
933-UTR-mediated mRNA stabilization (GO:0070935)2.76248815
94establishment of protein localization to endoplasmic reticulum (GO:0072599)2.72607262
95cellular protein complex disassembly (GO:0043624)2.71527335
96spliceosomal complex assembly (GO:0000245)2.70232658
97protein K63-linked deubiquitination (GO:0070536)2.70180534
98transcription from RNA polymerase I promoter (GO:0006360)2.69768107
99meiotic chromosome segregation (GO:0045132)2.69609479
100viral mRNA export from host cell nucleus (GO:0046784)2.69276795
101histone exchange (GO:0043486)2.69261598
102nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.69075998
103viral life cycle (GO:0019058)2.68602418
104peptidyl-lysine trimethylation (GO:0018023)2.68214597
105positive regulation of mitotic sister chromatid separation (GO:1901970)2.67462553
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.67462553
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.67462553
108positive regulation of DNA-templated transcription, initiation (GO:2000144)2.67429371
1097-methylguanosine mRNA capping (GO:0006370)2.66913545
110protein localization to endoplasmic reticulum (GO:0070972)2.66759462
111histone H3-K4 methylation (GO:0051568)2.64471368
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.64235325
113DNA synthesis involved in DNA repair (GO:0000731)2.63293204
114nucleotide-excision repair, DNA gap filling (GO:0006297)2.62851985
1157-methylguanosine RNA capping (GO:0009452)2.62706637
116RNA capping (GO:0036260)2.62706637
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62155433
118positive regulation of chromosome segregation (GO:0051984)2.61377363
119regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61334459
120maturation of 5.8S rRNA (GO:0000460)2.60556588
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.60365612
122regulation of centriole replication (GO:0046599)2.59889911
123regulation of centrosome cycle (GO:0046605)2.59644312
124negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.59541988
125protein K11-linked deubiquitination (GO:0035871)2.59436276
126somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.59433254
127somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.59433254
128isotype switching (GO:0045190)2.59433254
129cell cycle G1/S phase transition (GO:0044843)2.59367590
130G1/S transition of mitotic cell cycle (GO:0000082)2.59367590
131sister chromatid segregation (GO:0000819)2.59054233
132translation (GO:0006412)2.58825776
133RNA splicing, via transesterification reactions (GO:0000375)2.58825716
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56487036
135RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.54890166
136mRNA splicing, via spliceosome (GO:0000398)2.54890166
137regulation of histone methylation (GO:0031060)2.54839513
138mitotic G2 DNA damage checkpoint (GO:0007095)2.54293989
139piRNA metabolic process (GO:0034587)2.53087499
140positive regulation of mRNA catabolic process (GO:0061014)2.51239558
141gene silencing by RNA (GO:0031047)2.50405717
142protoporphyrinogen IX biosynthetic process (GO:0006782)2.49752464
143attachment of spindle microtubules to kinetochore (GO:0008608)2.48910439
144histone H2B ubiquitination (GO:0033523)2.48713417
145nuclear envelope organization (GO:0006998)2.48688286
146DNA geometric change (GO:0032392)2.48539459
147DNA duplex unwinding (GO:0032508)2.48537726
148histone H2A ubiquitination (GO:0033522)2.45358582
149positive regulation of histone methylation (GO:0031062)2.44659389
150mRNA transport (GO:0051028)2.44202239
151embryonic hemopoiesis (GO:0035162)2.43606151
152ER overload response (GO:0006983)2.43311144
153mRNA export from nucleus (GO:0006406)2.43245991
154histone H3-K9 modification (GO:0061647)2.43218974
155regulation of DNA damage checkpoint (GO:2000001)2.42505584
156negative regulation of DNA-dependent DNA replication (GO:2000104)2.40039721
157RNA export from nucleus (GO:0006405)2.39565992
158postreplication repair (GO:0006301)2.39143197
159peptidyl-lysine methylation (GO:0018022)2.38438557
160nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.38001656
161regulation of mRNA catabolic process (GO:0061013)2.37673917
162histone H3-K9 methylation (GO:0051567)2.37525982
163negative regulation of execution phase of apoptosis (GO:1900118)2.36828112
164regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.36458924
165T cell migration (GO:0072678)2.36431581
166mitochondrial RNA metabolic process (GO:0000959)2.34363136
167positive regulation of mRNA 3-end processing (GO:0031442)2.34048992
168positive regulation of protein homooligomerization (GO:0032464)2.33522156
169histone monoubiquitination (GO:0010390)2.32623986
170histone demethylation (GO:0016577)2.32055266
171DNA topological change (GO:0006265)2.32027413
172necroptotic process (GO:0070266)2.30583040
173nucleus organization (GO:0006997)2.29851015
174histone ubiquitination (GO:0016574)2.29698247
175protein K48-linked deubiquitination (GO:0071108)2.29541385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.00161338
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.06232238
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.87828214
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44138188
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07381275
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.03525262
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02137601
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01632037
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96916630
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.79472245
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74792437
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72336395
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.68837894
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.65953542
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55747260
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51528647
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36744694
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31090624
19VDR_23849224_ChIP-Seq_CD4+_Human2.30512937
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14890060
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14211367
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11031803
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10138008
24ELK1_19687146_ChIP-ChIP_HELA_Human2.09958050
25XRN2_22483619_ChIP-Seq_HELA_Human2.09624213
26GATA1_22025678_ChIP-Seq_K562_Human2.02087869
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01999390
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96046036
29DCP1A_22483619_ChIP-Seq_HELA_Human1.92449213
30FOXP3_21729870_ChIP-Seq_TREG_Human1.87282354
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86362870
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85742886
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.85602458
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84020270
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83503585
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81500374
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81319819
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81166646
39TTF2_22483619_ChIP-Seq_HELA_Human1.80334148
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80245470
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.79175446
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.79175446
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.79175446
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.74327991
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70278831
46MYB_26560356_Chip-Seq_TH2_Human1.67672478
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64904134
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62063768
49AR_21909140_ChIP-Seq_LNCAP_Human1.61262615
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56510801
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52961430
52GABP_19822575_ChIP-Seq_HepG2_Human1.52897196
53MYB_26560356_Chip-Seq_TH1_Human1.52206548
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51958054
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49359084
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48505272
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46773020
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46225536
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45876968
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.45806000
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42372797
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.40628221
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40617825
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38184760
65MYC_22102868_ChIP-Seq_BL_Human1.37798464
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36424895
67SCL_19346495_ChIP-Seq_HPC-7_Human1.35740841
68CIITA_25753668_ChIP-Seq_RAJI_Human1.35449479
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34964436
70EWS_26573619_Chip-Seq_HEK293_Human1.31873758
71TFEB_21752829_ChIP-Seq_HELA_Human1.31637682
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29571332
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28761577
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.27543090
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27145534
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26624421
77IRF1_19129219_ChIP-ChIP_H3396_Human1.26489416
78KDM5A_27292631_Chip-Seq_BREAST_Human1.25842327
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25652675
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21188579
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19547655
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18748730
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18535120
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17841112
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.15953111
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15433651
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.14204696
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13993054
89SPI1_23547873_ChIP-Seq_NB4_Human1.13422169
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11907799
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11494378
92PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11137506
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10947497
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.10520476
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09974846
96RUNX_20019798_ChIP-Seq_JUKART_Human1.09822467
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09385557
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06817879
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05809369
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05707305
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05630532
102ZNF274_21170338_ChIP-Seq_K562_Hela1.05190922
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04892039
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04221501
105SALL1_21062744_ChIP-ChIP_HESCs_Human1.03498249
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.02155806
107GATA3_26560356_Chip-Seq_TH2_Human1.02005913
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01901855
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99829475
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98777876
111CHD1_26751641_Chip-Seq_LNCaP_Human0.98570244
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.97671709
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97565111
114MAF_26560356_Chip-Seq_TH1_Human0.95714884
115GATA1_19941826_ChIP-Seq_K562_Human0.95390263
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95342054
117BP1_19119308_ChIP-ChIP_Hs578T_Human0.94318399
118BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92950165
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92491466
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92206420
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91171563
122MYC_18940864_ChIP-ChIP_HL60_Human0.91151525
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89975449
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89536601
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89020901
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88582603
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88332757
128MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86774745
129SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83061418
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81677394
131TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81227551
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81028607
133CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80629018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.66751312
2MP0003693_abnormal_embryo_hatching4.61101606
3MP0002009_preneoplasia3.96561950
4MP0010094_abnormal_chromosome_stability3.71481634
5MP0004957_abnormal_blastocyst_morpholog3.71198685
6MP0003111_abnormal_nucleus_morphology3.64271989
7MP0003077_abnormal_cell_cycle3.52772670
8MP0003656_abnormal_erythrocyte_physiolo3.37301710
9MP0008058_abnormal_DNA_repair2.97237848
10MP0008007_abnormal_cellular_replicative2.86026057
11MP0008932_abnormal_embryonic_tissue2.20904706
12MP0003221_abnormal_cardiomyocyte_apopto2.09705002
13MP0002166_altered_tumor_susceptibility2.08030325
14MP0010352_gastrointestinal_tract_polyps2.07482329
15MP0004147_increased_porphyrin_level2.00475553
16MP0000350_abnormal_cell_proliferation1.93243073
17MP0002396_abnormal_hematopoietic_system1.90460522
18MP0002006_tumorigenesis1.86524287
19MP0003786_premature_aging1.86417428
20MP0001730_embryonic_growth_arrest1.75388356
21MP0009333_abnormal_splenocyte_physiolog1.73317084
22MP0010307_abnormal_tumor_latency1.66572741
23MP0008877_abnormal_DNA_methylation1.63600003
24MP0004808_abnormal_hematopoietic_stem1.61956593
25MP0003123_paternal_imprinting1.55850042
26MP0005076_abnormal_cell_differentiation1.51115174
27MP0006292_abnormal_olfactory_placode1.49857630
28MP0000490_abnormal_crypts_of1.48052192
29MP0009697_abnormal_copulation1.43028735
30MP0005380_embryogenesis_phenotype1.42217961
31MP0001672_abnormal_embryogenesis/_devel1.42217961
32MP0002277_abnormal_respiratory_mucosa1.40359375
33MP0002877_abnormal_melanocyte_morpholog1.37277070
34MP0001697_abnormal_embryo_size1.33175186
35MP0001545_abnormal_hematopoietic_system1.32353124
36MP0005397_hematopoietic_system_phenotyp1.32353124
37MP0003436_decreased_susceptibility_to1.30053958
38MP0003718_maternal_effect1.25965782
39MP0001835_abnormal_antigen_presentation1.25465657
40MP0002398_abnormal_bone_marrow1.25222985
41MP0003984_embryonic_growth_retardation1.24291712
42MP0002019_abnormal_tumor_incidence1.23052123
43MP0002088_abnormal_embryonic_growth/wei1.22932721
44MP0002085_abnormal_embryonic_tissue1.21460833
45MP0000313_abnormal_cell_death1.21200582
46MP0004133_heterotaxia1.19408241
47MP0002080_prenatal_lethality1.18608433
48MP0002086_abnormal_extraembryonic_tissu1.18459020
49MP0008961_abnormal_basal_metabolism1.17839941
50MP0002722_abnormal_immune_system1.17790647
51MP0000689_abnormal_spleen_morphology1.17089682
52MP0002148_abnormal_hypersensitivity_rea1.16103982
53MP0003315_abnormal_perineum_morphology1.14685547
54MP0006054_spinal_hemorrhage1.14330008
55MP0000703_abnormal_thymus_morphology1.13952317
56MP0010030_abnormal_orbit_morphology1.13719650
57MP0001929_abnormal_gametogenesis1.13368123
58MP0005187_abnormal_penis_morphology1.13147755
59MP0004197_abnormal_fetal_growth/weight/1.12951465
60MP0005671_abnormal_response_to1.12807147
61MP0002452_abnormal_antigen_presenting1.12770203
62MP0002405_respiratory_system_inflammati1.12348651
63MP0004381_abnormal_hair_follicle1.11282323
64MP0002084_abnormal_developmental_patter1.11180319
65MP0003763_abnormal_thymus_physiology1.10933582
66MP0001800_abnormal_humoral_immune1.10020287
67MP0003567_abnormal_fetal_cardiomyocyte1.10000429
68MP0005310_abnormal_salivary_gland1.09040825
69MP0003448_altered_tumor_morphology1.09024873
70MP0005000_abnormal_immune_tolerance1.08975769
71MP0003941_abnormal_skin_development1.07650325
72MP0001727_abnormal_embryo_implantation1.07588088
73MP0000858_altered_metastatic_potential1.01952265
74MP0002420_abnormal_adaptive_immunity1.00963544
75MP0001819_abnormal_immune_cell1.00855182
76MP0010678_abnormal_skin_adnexa1.00745090
77MP0009785_altered_susceptibility_to1.00019244
78MP0009278_abnormal_bone_marrow0.99340283
79MP0002429_abnormal_blood_cell0.98478231
80MP0002132_abnormal_respiratory_system0.97945141
81MP0002723_abnormal_immune_serum0.97635116
82MP0002095_abnormal_skin_pigmentation0.96478002
83MP0000716_abnormal_immune_system0.96345648
84MP0003950_abnormal_plasma_membrane0.96027566
85MP0005083_abnormal_biliary_tract0.95921359
86MP0002210_abnormal_sex_determination0.93888458
87MP0005023_abnormal_wound_healing0.93727465
88MP0001293_anophthalmia0.91175727
89MP0003566_abnormal_cell_adhesion0.90937919
90MP0010234_abnormal_vibrissa_follicle0.86157353
91MP0000647_abnormal_sebaceous_gland0.85916997
92MP0006035_abnormal_mitochondrial_morpho0.85474478
93MP0001853_heart_inflammation0.84914084
94MP0003699_abnormal_female_reproductive0.84204409
95MP0005621_abnormal_cell_physiology0.84151054
96MP0005174_abnormal_tail_pigmentation0.84073571
97MP0003890_abnormal_embryonic-extraembry0.83684818
98MP0000685_abnormal_immune_system0.81142662
99MP0000383_abnormal_hair_follicle0.80723932
100MP0005387_immune_system_phenotype0.79698938
101MP0000569_abnormal_digit_pigmentation0.79625002
102MP0003943_abnormal_hepatobiliary_system0.79608741
103MP0000015_abnormal_ear_pigmentation0.78669633
104MP0002419_abnormal_innate_immunity0.78571125
105MP0003121_genomic_imprinting0.77887720
106MP0000465_gastrointestinal_hemorrhage0.77665725
107MP0001145_abnormal_male_reproductive0.76666279
108MP0005025_abnormal_response_to0.76596277
109MP0005075_abnormal_melanosome_morpholog0.74910012
110MP0001191_abnormal_skin_condition0.73321005
111MP0008995_early_reproductive_senescence0.71666988
112MP0005384_cellular_phenotype0.71604778
113MP0009764_decreased_sensitivity_to0.71455139
114MP0003937_abnormal_limbs/digits/tail_de0.69867222
115MP0004947_skin_inflammation0.69743201
116MP0009379_abnormal_foot_pigmentation0.69516712
117MP0000372_irregular_coat_pigmentation0.69365267
118MP0001919_abnormal_reproductive_system0.69042914
119MP0003724_increased_susceptibility_to0.69025637
120MP0000358_abnormal_cell_content/0.68650426
121MP0001119_abnormal_female_reproductive0.68632674
122MP0000516_abnormal_urinary_system0.68478805
123MP0005367_renal/urinary_system_phenotyp0.68478805
124MP0003186_abnormal_redox_activity0.68382339
125MP0002098_abnormal_vibrissa_morphology0.68012786
126MP0000427_abnormal_hair_cycle0.67972571
127MP0005389_reproductive_system_phenotype0.67567053
128MP0003828_pulmonary_edema0.64951963
129MP0003119_abnormal_digestive_system0.64805445
130MP0000653_abnormal_sex_gland0.64797597
131MP0001790_abnormal_immune_system0.64338361

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.15022767
2Reticulocytopenia (HP:0001896)3.57566834
3Agnosia (HP:0010524)3.45312315
4Chromsome breakage (HP:0040012)3.43065664
5Carpal bone hypoplasia (HP:0001498)3.35482352
6Poikilocytosis (HP:0004447)3.34810409
7Breast hypoplasia (HP:0003187)3.34660963
8Septate vagina (HP:0001153)3.26725618
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23356323
10Abnormality of cells of the erythroid lineage (HP:0012130)3.13968700
11Abnormal number of erythroid precursors (HP:0012131)2.95812574
12Rough bone trabeculation (HP:0100670)2.90293318
13Abnormality of the heme biosynthetic pathway (HP:0010472)2.90268876
14Patellar aplasia (HP:0006443)2.86093230
15Stenosis of the external auditory canal (HP:0000402)2.83938960
16Cutaneous melanoma (HP:0012056)2.79989366
17Aplasia/Hypoplasia of the patella (HP:0006498)2.79205567
18Fair hair (HP:0002286)2.74529589
19Aplastic anemia (HP:0001915)2.73194096
20Meckel diverticulum (HP:0002245)2.71988766
21Abnormality of alanine metabolism (HP:0010916)2.71121834
22Hyperalaninemia (HP:0003348)2.71121834
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71121834
24Cerebral hypomyelination (HP:0006808)2.70126066
25T lymphocytopenia (HP:0005403)2.65081675
26Absent radius (HP:0003974)2.63176818
27Abnormality of the renal collecting system (HP:0004742)2.62816198
28Abnormality of T cell physiology (HP:0011840)2.60734542
29Colon cancer (HP:0003003)2.59024086
30Papillary thyroid carcinoma (HP:0002895)2.58069073
31Abnormality of the ileum (HP:0001549)2.57390979
32Medulloblastoma (HP:0002885)2.56474614
33Abnormality of T cell number (HP:0011839)2.55757703
34Abnormality of chromosome stability (HP:0003220)2.52141092
35Macrocytic anemia (HP:0001972)2.50716678
36Pallor (HP:0000980)2.50385018
37Recurrent viral infections (HP:0004429)2.48756390
38Abnormality of T cells (HP:0002843)2.45083938
39Myelodysplasia (HP:0002863)2.44456389
40Irregular epiphyses (HP:0010582)2.43183733
41Autoimmune hemolytic anemia (HP:0001890)2.42654647
42Aplasia involving forearm bones (HP:0009822)2.42286621
43Absent forearm bone (HP:0003953)2.42286621
44Abnormality of the preputium (HP:0100587)2.39860216
45Selective tooth agenesis (HP:0001592)2.37633942
46Fatigue (HP:0012378)2.37365123
47Premature graying of hair (HP:0002216)2.36389946
48Small epiphyses (HP:0010585)2.31751290
4911 pairs of ribs (HP:0000878)2.31657195
50Absent thumb (HP:0009777)2.31461846
51Bone marrow hypocellularity (HP:0005528)2.30710046
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.29229662
53Abnormal trabecular bone morphology (HP:0100671)2.27714710
54Acute lymphatic leukemia (HP:0006721)2.27667326
55IgG deficiency (HP:0004315)2.27649633
56Oral leukoplakia (HP:0002745)2.26404012
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24916971
58Glossoptosis (HP:0000162)2.24398238
59Ependymoma (HP:0002888)2.23967216
60Supernumerary spleens (HP:0009799)2.23901686
61Rib fusion (HP:0000902)2.23397952
62Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22592194
63Thyroid carcinoma (HP:0002890)2.21607707
64Dyschromatopsia (HP:0007641)2.21360447
65Abnormality of the anterior horn cell (HP:0006802)2.20199458
66Degeneration of anterior horn cells (HP:0002398)2.20199458
67Lymphoma (HP:0002665)2.14897846
68Short middle phalanx of the 5th finger (HP:0004220)2.13451282
69Abnormality of the fingertips (HP:0001211)2.10217639
70Abnormality of the labia minora (HP:0012880)2.09130648
71Amaurosis fugax (HP:0100576)2.07877549
72Impulsivity (HP:0100710)2.06491938
73Tracheoesophageal fistula (HP:0002575)2.06395439
74Trismus (HP:0000211)2.02894557
75Deep philtrum (HP:0002002)2.02810464
76Ectopic kidney (HP:0000086)2.02744470
77Autoimmune thrombocytopenia (HP:0001973)2.00285771
78Neoplasm of the pancreas (HP:0002894)1.99580733
79Nephroblastoma (Wilms tumor) (HP:0002667)1.98913776
80Truncal obesity (HP:0001956)1.97528447
81Duplicated collecting system (HP:0000081)1.96786457
82Asplenia (HP:0001746)1.96494786
83Progressive muscle weakness (HP:0003323)1.96057505
84Abnormality of the pons (HP:0007361)1.95969979
85Sloping forehead (HP:0000340)1.93791120
86Premature ovarian failure (HP:0008209)1.93623298
87Prominent nose (HP:0000448)1.92687877
88Tinnitus (HP:0000360)1.92670151
89Central scotoma (HP:0000603)1.92159441
90Generalized hypopigmentation of hair (HP:0011358)1.90710606
91Rhabdomyosarcoma (HP:0002859)1.90192068
92Metaphyseal cupping (HP:0003021)1.89361016
93Abnormality of homocysteine metabolism (HP:0010919)1.88182450
94Homocystinuria (HP:0002156)1.88182450
95Short thumb (HP:0009778)1.87986101
96Muscle fiber atrophy (HP:0100295)1.87757040
97Stomach cancer (HP:0012126)1.87353443
98Prostate neoplasm (HP:0100787)1.86841637
99Poikiloderma (HP:0001029)1.86826231
100Sandal gap (HP:0001852)1.86434099
101Triphalangeal thumb (HP:0001199)1.86151267
102Small intestinal stenosis (HP:0012848)1.86018793
103Duodenal stenosis (HP:0100867)1.86018793
104IgA deficiency (HP:0002720)1.85656487
105Pustule (HP:0200039)1.84962257
106Atresia of the external auditory canal (HP:0000413)1.84494075
107Cafe-au-lait spot (HP:0000957)1.84325625
108Progressive inability to walk (HP:0002505)1.84025193
109Abnormality of chromosome segregation (HP:0002916)1.83679894
110Capillary hemangiomas (HP:0005306)1.82828150
111Embryonal renal neoplasm (HP:0011794)1.82736041
112Stomatitis (HP:0010280)1.82664992
113Progressive external ophthalmoplegia (HP:0000590)1.81817229
114Abnormality of the renal cortex (HP:0011035)1.81717145
115Horseshoe kidney (HP:0000085)1.81716325
116Entropion (HP:0000621)1.81326322
117Subacute progressive viral hepatitis (HP:0006572)1.81101223
118Lip pit (HP:0100267)1.81048110
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.81004661
120Volvulus (HP:0002580)1.80882715
121Septo-optic dysplasia (HP:0100842)1.80679280
122Abnormal lung lobation (HP:0002101)1.80410079
123Deviation of the thumb (HP:0009603)1.79566277
124Anhidrosis (HP:0000970)1.79557685
125Type I transferrin isoform profile (HP:0003642)1.78345086
126Poor head control (HP:0002421)1.78172233
127Viral hepatitis (HP:0006562)1.77916392
128IgM deficiency (HP:0002850)1.77672077
129Melanoma (HP:0002861)1.76803465
130Proximal placement of thumb (HP:0009623)1.76436021
131Aplasia/Hypoplasia of the spleen (HP:0010451)1.76435702
132Overlapping toe (HP:0001845)1.76331155
133Cleft eyelid (HP:0000625)1.75444582
134Limb hypertonia (HP:0002509)1.75383118
135Absent epiphyses (HP:0010577)1.74380962
136Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74380962
137Thrombocytosis (HP:0001894)1.74331613
138Acute myeloid leukemia (HP:0004808)1.73611594
139Basal cell carcinoma (HP:0002671)1.73470159
140Clubbing of toes (HP:0100760)1.72969403
141Abnormal number of incisors (HP:0011064)1.72813506
142Syringomyelia (HP:0003396)1.72754570
143Spinal cord lesions (HP:0100561)1.72754570
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72399852
145Flat capital femoral epiphysis (HP:0003370)1.71909509
146Hypoplasia of the radius (HP:0002984)1.70976099
147Cellular immunodeficiency (HP:0005374)1.70065301
148Granulocytopenia (HP:0001913)1.69906326
149Missing ribs (HP:0000921)1.69548367
150Chronic diarrhea (HP:0002028)1.66837558
151Abnormality of DNA repair (HP:0003254)1.66291152
152Abnormality of abdominal situs (HP:0011620)1.65713288
153Abdominal situs inversus (HP:0003363)1.65713288
154Recurrent abscess formation (HP:0002722)1.65414019
155Acute hepatic failure (HP:0006554)1.64676357
156Aplasia cutis congenita (HP:0001057)1.64104345
157Secondary amenorrhea (HP:0000869)1.64099071
158Spinal muscular atrophy (HP:0007269)1.63605088
159Abnormality of the duodenum (HP:0002246)1.63470792
160Fused cervical vertebrae (HP:0002949)1.63021601
161Freckling (HP:0001480)1.62688781
162Squamous cell carcinoma (HP:0002860)1.62222824
163Gastrointestinal infarctions (HP:0005244)1.61790041
164Aseptic necrosis (HP:0010885)1.61601265
165Pheochromocytoma (HP:0002666)1.61465872
166Albinism (HP:0001022)1.61174553
167Microvesicular hepatic steatosis (HP:0001414)1.60534475
168CNS hypomyelination (HP:0003429)1.59888292
169Lower limb hyperreflexia (HP:0002395)1.59094048
170Reticulocytosis (HP:0001923)1.58885109
171Partial agenesis of the corpus callosum (HP:0001338)1.58816688
172Microretrognathia (HP:0000308)1.58628255
173Encephalitis (HP:0002383)1.56602836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.79766156
2WEE13.65309110
3TSSK63.14334063
4CDC72.82520234
5EIF2AK12.52060701
6MKNK12.38479666
7TAOK32.32847045
8NME22.31983158
9BRSK22.25646640
10PLK42.22734241
11MKNK22.16121935
12EIF2AK32.10173682
13STK162.08729304
14ACVR1B2.07207386
15EPHA21.94729092
16SRPK11.94470618
17TRIM281.83280588
18NEK21.81846756
19TTK1.75944984
20PBK1.74274304
21CDK121.74135916
22PLK11.74074434
23STK101.73209333
24PRPF4B1.73162185
25VRK11.72655895
26PLK31.71917930
27RPS6KB21.68615100
28TLK11.68093633
29PIM21.59884827
30RPS6KA41.59314298
31EEF2K1.59258193
32IRAK31.43907969
33PIM11.42055386
34CDK71.37059503
35TGFBR11.36550070
36MST41.36469581
37EIF2AK21.36431781
38BMPR21.36389828
39ZAK1.35959423
40ATR1.35477816
41DYRK31.34457041
42ERBB31.33269662
43MAP3K131.33039158
44SIK31.32812084
45CAMK1D1.32011584
46AURKB1.31808124
47PASK1.29189057
48CAMKK21.27387511
49IKBKB1.26906580
50IKBKE1.24579358
51BMPR1B1.22316982
52BRD41.18769531
53NME11.16375628
54MAP3K141.14690155
55MAP4K11.13268363
56MAP3K91.09730949
57IRAK11.08434455
58CHEK21.05855325
59BRSK11.05466381
60CHEK11.02541944
61AURKA1.01957240
62TXK0.98459509
63MAP3K80.98048013
64CAMK1G0.97311515
65CHUK0.94071813
66TEC0.93027738
67CDK40.92695351
68KSR20.91408167
69PAK40.91016212
70STK40.87074197
71MAP2K30.85479797
72CLK10.83164006
73IRAK40.81072000
74RPS6KA50.80664503
75ATM0.79415340
76STK30.77910116
77KSR10.77105867
78CDK20.75383917
79MARK30.73781041
80WNK10.71367263
81NUAK10.70719189
82TBK10.69901352
83MAP3K30.69460739
84CSNK2A10.67808245
85STK38L0.67679624
86MAP3K50.67061791
87CSNK2A20.66704717
88ALK0.66512599
89AKT30.65548212
90RAF10.65486516
91MELK0.65422036
92PNCK0.64870108
93MAP3K100.62588477
94TRPM70.61681608
95CDK90.59826248
96BCR0.57511935
97PDK20.56938901
98YES10.56007613
99NEK90.55728396
100JAK20.53388065
101MAP3K20.52856766
102CDK60.51773235
103IRAK20.51552433
104CDK10.51533188
105TAOK20.51098969
106BTK0.50715958
107CDK30.50416891
108HCK0.49333264
109SYK0.48963396
110PRKCI0.47028177
111ITK0.47020713
112CDK80.46501142
113NEK60.45335822
114PAK10.45041142
115MOS0.41536505
116MAP3K110.41115488
117STK240.40360792
118TESK20.40234668
119LYN0.39160928
120CSF1R0.37927434
121JAK30.37164851
122TGFBR20.36340786
123MAPKAPK20.34512287
124LCK0.33837306
125KDR0.33741556
126GRK60.33325736
127ABL20.32611056
128RPS6KA60.30896590
129NLK0.30428413
130ZAP700.29433814
131CCNB10.29333648
132RPS6KC10.29055858
133RPS6KL10.29055858

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.68947257
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52567923
3RNA polymerase_Homo sapiens_hsa030203.35053700
4Mismatch repair_Homo sapiens_hsa034303.32110146
5Ribosome_Homo sapiens_hsa030103.30946887
6Spliceosome_Homo sapiens_hsa030403.03151055
7Proteasome_Homo sapiens_hsa030502.96683328
8RNA transport_Homo sapiens_hsa030132.86940052
9Homologous recombination_Homo sapiens_hsa034402.68885275
10Base excision repair_Homo sapiens_hsa034102.55736228
11Nucleotide excision repair_Homo sapiens_hsa034202.33503943
12Cell cycle_Homo sapiens_hsa041102.32214952
13Pyrimidine metabolism_Homo sapiens_hsa002402.17979019
14Fanconi anemia pathway_Homo sapiens_hsa034602.14132433
15Non-homologous end-joining_Homo sapiens_hsa034502.05186276
16Basal transcription factors_Homo sapiens_hsa030222.01737653
17One carbon pool by folate_Homo sapiens_hsa006701.99684936
18Selenocompound metabolism_Homo sapiens_hsa004501.97180365
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93056190
20RNA degradation_Homo sapiens_hsa030181.81439337
21p53 signaling pathway_Homo sapiens_hsa041151.68362148
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62010879
23Circadian rhythm_Homo sapiens_hsa047101.55166602
24mRNA surveillance pathway_Homo sapiens_hsa030151.45682354
25Epstein-Barr virus infection_Homo sapiens_hsa051691.40010492
26Legionellosis_Homo sapiens_hsa051341.22713767
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.19557724
28Herpes simplex infection_Homo sapiens_hsa051681.19385475
29Regulation of autophagy_Homo sapiens_hsa041401.17539343
30Dorso-ventral axis formation_Homo sapiens_hsa043201.15924509
31Purine metabolism_Homo sapiens_hsa002301.12981171
32Antigen processing and presentation_Homo sapiens_hsa046121.12732052
33Pancreatic cancer_Homo sapiens_hsa052121.12497108
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09435958
35Non-small cell lung cancer_Homo sapiens_hsa052231.08673932
36Graft-versus-host disease_Homo sapiens_hsa053321.04197638
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00914853
38Protein export_Homo sapiens_hsa030601.00547429
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96610423
40Leishmaniasis_Homo sapiens_hsa051400.96178492
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93468156
42Viral carcinogenesis_Homo sapiens_hsa052030.92900428
43Allograft rejection_Homo sapiens_hsa053300.91698335
44Bladder cancer_Homo sapiens_hsa052190.91123785
45Measles_Homo sapiens_hsa051620.87762510
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86792482
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81184666
48Systemic lupus erythematosus_Homo sapiens_hsa053220.80830357
49Hematopoietic cell lineage_Homo sapiens_hsa046400.80739533
50HTLV-I infection_Homo sapiens_hsa051660.80374343
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80267783
52Folate biosynthesis_Homo sapiens_hsa007900.78939330
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78670685
54Primary immunodeficiency_Homo sapiens_hsa053400.78665226
55Nitrogen metabolism_Homo sapiens_hsa009100.78105878
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77526697
57MicroRNAs in cancer_Homo sapiens_hsa052060.77099028
58Alcoholism_Homo sapiens_hsa050340.75907478
59Malaria_Homo sapiens_hsa051440.74985092
60Renal cell carcinoma_Homo sapiens_hsa052110.74737685
61Apoptosis_Homo sapiens_hsa042100.72663601
62Shigellosis_Homo sapiens_hsa051310.71364685
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70667720
64Oocyte meiosis_Homo sapiens_hsa041140.68175166
65TGF-beta signaling pathway_Homo sapiens_hsa043500.65007960
66Prolactin signaling pathway_Homo sapiens_hsa049170.64536486
67Asthma_Homo sapiens_hsa053100.64053010
68Small cell lung cancer_Homo sapiens_hsa052220.60438416
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.60057237
70Inositol phosphate metabolism_Homo sapiens_hsa005620.59890957
71Influenza A_Homo sapiens_hsa051640.59661498
72mTOR signaling pathway_Homo sapiens_hsa041500.59377084
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.58701966
74Hepatitis B_Homo sapiens_hsa051610.58379314
75Lysine degradation_Homo sapiens_hsa003100.57170042
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57150747
77Type I diabetes mellitus_Homo sapiens_hsa049400.54692013
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54663223
79Rheumatoid arthritis_Homo sapiens_hsa053230.53414955
80Hepatitis C_Homo sapiens_hsa051600.52925687
81TNF signaling pathway_Homo sapiens_hsa046680.49514782
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47580056
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47423093
84Osteoclast differentiation_Homo sapiens_hsa043800.47224120
85Chemokine signaling pathway_Homo sapiens_hsa040620.42895897
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.41789617
87Endometrial cancer_Homo sapiens_hsa052130.41532792
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41464083
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41389108
90Thyroid cancer_Homo sapiens_hsa052160.41142278
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.41099424
92Other glycan degradation_Homo sapiens_hsa005110.40265715
93Huntingtons disease_Homo sapiens_hsa050160.40122957
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39994764
95Tuberculosis_Homo sapiens_hsa051520.39966571
96Arachidonic acid metabolism_Homo sapiens_hsa005900.39535897
97Vitamin B6 metabolism_Homo sapiens_hsa007500.39482109
98T cell receptor signaling pathway_Homo sapiens_hsa046600.39099191
99Hippo signaling pathway_Homo sapiens_hsa043900.38774572
100B cell receptor signaling pathway_Homo sapiens_hsa046620.35465903
101Pentose phosphate pathway_Homo sapiens_hsa000300.35327764
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35207633
103Pertussis_Homo sapiens_hsa051330.35141766
104Prostate cancer_Homo sapiens_hsa052150.35050357
105Autoimmune thyroid disease_Homo sapiens_hsa053200.32791040
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32657023
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.32159677
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31983814
109Salmonella infection_Homo sapiens_hsa051320.31782214
110Notch signaling pathway_Homo sapiens_hsa043300.31542629
111Acute myeloid leukemia_Homo sapiens_hsa052210.31312837
112Colorectal cancer_Homo sapiens_hsa052100.31039217
113Pathways in cancer_Homo sapiens_hsa052000.30682248
114Toxoplasmosis_Homo sapiens_hsa051450.30647518
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30177595
116HIF-1 signaling pathway_Homo sapiens_hsa040660.30084438
117Chronic myeloid leukemia_Homo sapiens_hsa052200.29827841
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.26377891
119Phagosome_Homo sapiens_hsa041450.26359517
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26163475
121Glutathione metabolism_Homo sapiens_hsa004800.26107362
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25604384
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25487309
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23341829
125FoxO signaling pathway_Homo sapiens_hsa040680.20992978
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20711854

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