SDF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is believed to be a secretory protein. It has regions of similarity to hydrophilic segments of yeast mannosyltransferases. Its expression is ubiquitous and the gene appears to be relatively conserved among mammals. Alternate splicing results in both coding and non-coding variants. A pseudogene of this gene is located on chromosome 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.50929384
2central nervous system myelination (GO:0022010)6.50929384
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.05964931
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.77538072
5ATP synthesis coupled proton transport (GO:0015986)5.77538072
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.67339082
7fatty acid elongation (GO:0030497)5.08627222
8respiratory electron transport chain (GO:0022904)4.76530301
9electron transport chain (GO:0022900)4.67150573
10regulation of cellular amino acid metabolic process (GO:0006521)4.63976209
11protein neddylation (GO:0045116)4.54724350
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.49497342
13chaperone-mediated protein transport (GO:0072321)4.26083921
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.25698875
15long-chain fatty acid biosynthetic process (GO:0042759)4.17477329
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.15271677
17negative regulation of ligase activity (GO:0051352)4.06545428
18negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.06545428
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.02577155
20intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.98453261
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.98453261
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.98234324
23signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.98234324
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.98234324
25platelet dense granule organization (GO:0060155)3.79941278
26water-soluble vitamin biosynthetic process (GO:0042364)3.78662651
27signal transduction involved in DNA damage checkpoint (GO:0072422)3.75526627
28signal transduction involved in DNA integrity checkpoint (GO:0072401)3.75526627
29cullin deneddylation (GO:0010388)3.75280078
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.71491684
31dopamine biosynthetic process (GO:0042416)3.70701234
32signal transduction involved in cell cycle checkpoint (GO:0072395)3.69956558
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.67239242
34signal peptide processing (GO:0006465)3.61884410
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.61057704
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.60433974
37NADH dehydrogenase complex assembly (GO:0010257)3.60433974
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60433974
39protein complex biogenesis (GO:0070271)3.57605325
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.57041160
41protein deneddylation (GO:0000338)3.56205861
42termination of RNA polymerase III transcription (GO:0006386)3.52467173
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.52467173
44antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.47308877
45dopamine transport (GO:0015872)3.44326870
46positive regulation of ligase activity (GO:0051351)3.42404959
47regulation of cellular amine metabolic process (GO:0033238)3.41038545
48hydrogen ion transmembrane transport (GO:1902600)3.37981259
49regulation of mitochondrial translation (GO:0070129)3.35095687
50regulation of hexokinase activity (GO:1903299)3.31493733
51regulation of glucokinase activity (GO:0033131)3.31493733
52sequestering of actin monomers (GO:0042989)3.30919738
53peptidyl-histidine modification (GO:0018202)3.30599060
54C-terminal protein lipidation (GO:0006501)3.29928146
55protein-cofactor linkage (GO:0018065)3.29796764
56neurotransmitter uptake (GO:0001504)3.29240900
57cholesterol biosynthetic process (GO:0006695)3.25626201
58protein maturation by protein folding (GO:0022417)3.23375937
59ATP hydrolysis coupled proton transport (GO:0015991)3.23060067
60energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.23060067
61protein targeting to mitochondrion (GO:0006626)3.22083754
62amyloid precursor protein metabolic process (GO:0042982)3.20361330
63negative regulation of neurotransmitter transport (GO:0051589)3.17986735
64proton transport (GO:0015992)3.17159253
65myelination (GO:0042552)3.16426472
66rRNA modification (GO:0000154)3.16000081
67DNA deamination (GO:0045006)3.14500145
68GTP biosynthetic process (GO:0006183)3.14323815
69substantia nigra development (GO:0021762)3.14271427
70hydrogen transport (GO:0006818)3.12358913
71ensheathment of neurons (GO:0007272)3.11367732
72axon ensheathment (GO:0008366)3.11367732
73* mannosylation (GO:0097502)3.08234663
74protein localization to mitochondrion (GO:0070585)3.06051839
75establishment of protein localization to mitochondrion (GO:0072655)3.04995836
76dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.00954466
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99854830
78DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.99150658
79regulation of ubiquitin-protein transferase activity (GO:0051438)2.98632696
80respiratory chain complex IV assembly (GO:0008535)2.97654865
81negative regulation of protein ubiquitination (GO:0031397)2.97512635
82purine nucleoside triphosphate biosynthetic process (GO:0009145)2.97479266
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96921714
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96921714
85mitochondrial respiratory chain complex assembly (GO:0033108)2.96706032
86ATP biosynthetic process (GO:0006754)2.95720834
87positive regulation of cell cycle arrest (GO:0071158)2.93694346
88C-terminal protein amino acid modification (GO:0018410)2.93542352
89antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.92883658
90neuron cell-cell adhesion (GO:0007158)2.92815991
91nucleotide transmembrane transport (GO:1901679)2.91707659
92sterol biosynthetic process (GO:0016126)2.91485155
93regulation of ligase activity (GO:0051340)2.88914454
94inner mitochondrial membrane organization (GO:0007007)2.87931379
95cellular copper ion homeostasis (GO:0006878)2.87840487
96cellular response to zinc ion (GO:0071294)2.86954101
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85983302
98GPI anchor biosynthetic process (GO:0006506)2.83205142
99glycerophospholipid catabolic process (GO:0046475)2.78201608
100positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.74985015
101mitochondrial transport (GO:0006839)2.74956004
102negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.74676029
103response to redox state (GO:0051775)2.74283085
104intracellular protein transmembrane import (GO:0044743)2.74074289
105regulation of dopamine metabolic process (GO:0042053)2.72015310
106regulation of catecholamine metabolic process (GO:0042069)2.72015310
107phagosome maturation (GO:0090382)2.70911448
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70435732
109regulation of cilium movement (GO:0003352)2.70432775
110isoprenoid biosynthetic process (GO:0008299)2.70108696
111phenol-containing compound catabolic process (GO:0019336)2.68261547
112presynaptic membrane organization (GO:0097090)2.68094267
113L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67152200
114pseudouridine synthesis (GO:0001522)2.66648092
115proteasome assembly (GO:0043248)2.65458486
116negative regulation of protein localization to cell surface (GO:2000009)2.64558094
117GPI anchor metabolic process (GO:0006505)2.62659437
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61888991
119protein peptidyl-prolyl isomerization (GO:0000413)2.60867765
120presynaptic membrane assembly (GO:0097105)2.60862617
121purine-containing compound salvage (GO:0043101)2.59460336
122protein K11-linked ubiquitination (GO:0070979)2.59364015
123translation (GO:0006412)2.59053170
124glutathione derivative metabolic process (GO:1901685)2.58743559
125glutathione derivative biosynthetic process (GO:1901687)2.58743559
126adenosine metabolic process (GO:0046085)2.58732505
127neurotransmitter catabolic process (GO:0042135)2.58696680
128positive regulation of TOR signaling (GO:0032008)2.58680446
129amyloid precursor protein catabolic process (GO:0042987)2.58657357
130copper ion homeostasis (GO:0055070)2.57812176
131cytochrome complex assembly (GO:0017004)2.57636667
132ribonucleoside triphosphate biosynthetic process (GO:0009201)2.54191015
133oligodendrocyte differentiation (GO:0048709)2.51611179
134catechol-containing compound biosynthetic process (GO:0009713)2.50754776
135catecholamine biosynthetic process (GO:0042423)2.50754776
136mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.48725780
137transferrin transport (GO:0033572)2.48017203
138long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.45036830
139positive regulation of cellular amine metabolic process (GO:0033240)2.44623322
140ribosomal small subunit biogenesis (GO:0042274)2.43902786
141long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.42876503
142ER overload response (GO:0006983)2.39228114
143positive regulation of mitochondrial fission (GO:0090141)2.38416242
144regulation of feeding behavior (GO:0060259)2.36762701
145preassembly of GPI anchor in ER membrane (GO:0016254)2.34815842
146positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.34094731
147regulation of axon regeneration (GO:0048679)2.33351903
148regulation of neuron projection regeneration (GO:0070570)2.33351903
149viral protein processing (GO:0019082)2.33226785
150cotranslational protein targeting to membrane (GO:0006613)2.32567008
151pH reduction (GO:0045851)2.30678726
152regulation of phospholipid biosynthetic process (GO:0071071)2.30418443
153virion attachment to host cell (GO:0019062)2.30074281
154adhesion of symbiont to host cell (GO:0044650)2.30074281
155intracellular pH reduction (GO:0051452)2.29233228
156UTP biosynthetic process (GO:0006228)2.28980032
157trivalent inorganic cation transport (GO:0072512)2.27561352
158ferric iron transport (GO:0015682)2.27561352
159autophagic vacuole fusion (GO:0000046)2.24539524
160protein localization to endoplasmic reticulum (GO:0070972)2.24218412
161neuron remodeling (GO:0016322)2.24175636
162nucleoside diphosphate catabolic process (GO:0009134)2.23470588
163positive regulation of protein homodimerization activity (GO:0090073)2.21819470
164protein targeting to ER (GO:0045047)2.21603791
165aldehyde catabolic process (GO:0046185)2.21399369
166eye photoreceptor cell differentiation (GO:0001754)2.21018118
167photoreceptor cell differentiation (GO:0046530)2.21018118
168guanosine-containing compound biosynthetic process (GO:1901070)2.20933931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.04308537
2ELK1_19687146_ChIP-ChIP_HELA_Human3.17405140
3ETS1_20019798_ChIP-Seq_JURKAT_Human3.12022191
4ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82726135
5* VDR_23849224_ChIP-Seq_CD4+_Human2.73094748
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66431871
7GBX2_23144817_ChIP-Seq_PC3_Human2.46536727
8ZNF274_21170338_ChIP-Seq_K562_Hela2.45596767
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32239304
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31730100
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26444378
12VDR_22108803_ChIP-Seq_LS180_Human2.22552825
13TAF15_26573619_Chip-Seq_HEK293_Human2.20737995
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20431466
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18643509
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11234983
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10854150
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08609250
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.08373783
20FOXP3_21729870_ChIP-Seq_TREG_Human2.07778999
21* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05858937
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.98306533
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96981081
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94323921
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94063308
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93388931
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89863939
28DCP1A_22483619_ChIP-Seq_HELA_Human1.89241964
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.87681228
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83883859
31* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82363628
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81995749
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77508267
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73982789
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73842075
36EZH2_22144423_ChIP-Seq_EOC_Human1.73063683
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73002843
38* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71970916
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70919888
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70245263
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68570493
42* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67916986
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65581740
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64321230
45P300_19829295_ChIP-Seq_ESCs_Human1.64170219
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62421578
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61621394
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61510698
49FUS_26573619_Chip-Seq_HEK293_Human1.60599003
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59543387
51GABP_19822575_ChIP-Seq_HepG2_Human1.59395313
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58275177
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55360443
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53513291
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52623200
56AR_21572438_ChIP-Seq_LNCaP_Human1.49734882
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.49389334
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.49305396
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48734327
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48711415
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48711415
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48402411
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48402411
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46918940
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46219094
66ER_23166858_ChIP-Seq_MCF-7_Human1.45145763
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.43799837
68MYC_18940864_ChIP-ChIP_HL60_Human1.42048720
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41818537
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.40428539
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.36015017
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.35323549
73MYC_18555785_ChIP-Seq_MESCs_Mouse1.30871771
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.30390853
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.29470517
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29221849
77* TP53_22573176_ChIP-Seq_HFKS_Human1.28654885
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28350150
79HTT_18923047_ChIP-ChIP_STHdh_Human1.27063015
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24824453
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24437067
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.24130277
83TP53_18474530_ChIP-ChIP_U2OS_Human1.24035269
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23773896
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22517545
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22399027
87* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21296511
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20985826
89* AR_20517297_ChIP-Seq_VCAP_Human1.20107736
90IGF1R_20145208_ChIP-Seq_DFB_Human1.19793288
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16938011
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16071934
93* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15456211
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15380813
95TTF2_22483619_ChIP-Seq_HELA_Human1.15256312
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15208266
97* ELK1_22589737_ChIP-Seq_MCF10A_Human1.14322485
98* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13243018
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13225724
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13120865
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12897142
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.10398541
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10398541
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09242623
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.08074438
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07534286
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05924707
108PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04667400
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04504770
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03778962
111EWS_26573619_Chip-Seq_HEK293_Human1.03747398
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02425817
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.02391324
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02099078
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.00889825
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00734964
117SMAD3_21741376_ChIP-Seq_EPCs_Human1.00345175
118SALL4_22934838_ChIP-ChIP_CD34+_Human0.99074850
119SOX2_19829295_ChIP-Seq_ESCs_Human0.97341900
120NANOG_19829295_ChIP-Seq_ESCs_Human0.97341900
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96819725
122RNF2_27304074_Chip-Seq_NSC_Mouse0.96704018
123ELF5_23300383_ChIP-Seq_T47D_Human0.96647770
124PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96052893
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95603135
126HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95198176
127JUN_21703547_ChIP-Seq_K562_Human0.95099001
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.94932158
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94908318
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94272105
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94244174
132EOMES_21245162_ChIP-Seq_HESCs_Human0.94118702
133SOX2_20726797_ChIP-Seq_SW620_Human0.93283734
134REST_21632747_ChIP-Seq_MESCs_Mouse0.93152838
135WT1_19549856_ChIP-ChIP_CCG9911_Human0.92947740
136IRF1_19129219_ChIP-ChIP_H3396_Human0.92418750
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92106598
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.90879610
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90719140
140SMAD4_21799915_ChIP-Seq_A2780_Human0.90659924
141ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89094372
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.86801819
143AR_25329375_ChIP-Seq_VCAP_Human0.86544754
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.86361073
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84416510
146* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84162441
147TFEB_21752829_ChIP-Seq_HELA_Human0.83971713
148ERG_20517297_ChIP-Seq_VCAP_Human0.82706747
149FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82355652
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82350525
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.81463518
152NFE2_27457419_Chip-Seq_LIVER_Mouse0.80628538
153SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79555714
154YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77798351
155* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77129149
156XRN2_22483619_ChIP-Seq_HELA_Human0.76653748
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76059525
158BCAT_22108803_ChIP-Seq_LS180_Human0.75934936
159SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75464582
160PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75296920
161CRX_20693478_ChIP-Seq_RETINA_Mouse0.74014594
162NANOG_16153702_ChIP-ChIP_HESCs_Human0.73828747
163NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73009174
164CBP_20019798_ChIP-Seq_JUKART_Human0.72682899

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.83593751
2MP0001905_abnormal_dopamine_level3.60262771
3MP0001529_abnormal_vocalization3.36401961
4MP0002102_abnormal_ear_morphology3.13592913
5MP0000920_abnormal_myelination2.66789182
6MP0004147_increased_porphyrin_level2.62884410
7MP0003136_yellow_coat_color2.58589331
8MP0006276_abnormal_autonomic_nervous2.57894812
9MP0002277_abnormal_respiratory_mucosa2.50138982
10MP0006054_spinal_hemorrhage2.38384633
11MP0009379_abnormal_foot_pigmentation2.30706949
12MP0002139_abnormal_hepatobiliary_system2.21201367
13MP0005379_endocrine/exocrine_gland_phen2.19201307
14MP0001764_abnormal_homeostasis2.16541757
15MP0003329_amyloid_beta_deposits2.11683375
16MP0001440_abnormal_grooming_behavior2.09516563
17MP0005360_urolithiasis2.06985573
18MP0008875_abnormal_xenobiotic_pharmacok2.05350594
19MP0003718_maternal_effect2.05060936
20MP0010386_abnormal_urinary_bladder2.04447381
21MP0002736_abnormal_nociception_after2.01731008
22MP0002064_seizures2.01290094
23MP0009046_muscle_twitch1.95674397
24MP0005084_abnormal_gallbladder_morpholo1.94515629
25MP0002272_abnormal_nervous_system1.91987511
26MP0003690_abnormal_glial_cell1.91080557
27MP0005171_absent_coat_pigmentation1.87002269
28MP0009840_abnormal_foam_cell1.86613418
29MP0004270_analgesia1.85277134
30MP0002938_white_spotting1.83912362
31MP0009745_abnormal_behavioral_response1.79952195
32MP0009697_abnormal_copulation1.79332744
33MP0006035_abnormal_mitochondrial_morpho1.76307672
34MP0004142_abnormal_muscle_tone1.75664102
35MP0005646_abnormal_pituitary_gland1.75183350
36MP0000372_irregular_coat_pigmentation1.75004388
37MP0002734_abnormal_mechanical_nocicepti1.74480953
38MP0003950_abnormal_plasma_membrane1.73137986
39MP0001968_abnormal_touch/_nociception1.70219553
40MP0005423_abnormal_somatic_nervous1.66957686
41MP0005075_abnormal_melanosome_morpholog1.62498607
42MP0002163_abnormal_gland_morphology1.59714803
43MP0002733_abnormal_thermal_nociception1.59306747
44MP0002837_dystrophic_cardiac_calcinosis1.58751975
45MP0001970_abnormal_pain_threshold1.57315442
46MP0002572_abnormal_emotion/affect_behav1.56834382
47MP0001984_abnormal_olfaction1.55788703
48MP0003786_premature_aging1.53696408
49MP0005409_darkened_coat_color1.52370487
50MP0003634_abnormal_glial_cell1.52037655
51MP0008058_abnormal_DNA_repair1.51763954
52MP0005332_abnormal_amino_acid1.50882694
53MP0001542_abnormal_bone_strength1.49468968
54MP0004742_abnormal_vestibular_system1.44459039
55MP0002638_abnormal_pupillary_reflex1.44237984
56MP0002876_abnormal_thyroid_physiology1.43916344
57MP0001486_abnormal_startle_reflex1.43777045
58MP0008877_abnormal_DNA_methylation1.42534638
59MP0002295_abnormal_pulmonary_circulatio1.41320508
60MP0009384_cardiac_valve_regurgitation1.39410189
61MP0008789_abnormal_olfactory_epithelium1.37808291
62MP0003635_abnormal_synaptic_transmissio1.36950832
63MP0001501_abnormal_sleep_pattern1.36461939
64MP0005058_abnormal_lysosome_morphology1.34293850
65MP0001502_abnormal_circadian_rhythm1.33741257
66MP0005551_abnormal_eye_electrophysiolog1.32012691
67MP0005408_hypopigmentation1.31472101
68MP0001986_abnormal_taste_sensitivity1.31123784
69MP0000516_abnormal_urinary_system1.28553653
70MP0005367_renal/urinary_system_phenotyp1.28553653
71MP0006072_abnormal_retinal_apoptosis1.28046877
72MP0005645_abnormal_hypothalamus_physiol1.27815944
73MP0002735_abnormal_chemical_nociception1.27762488
74MP0002132_abnormal_respiratory_system1.25008391
75MP0002067_abnormal_sensory_capabilities1.18131860
76MP0003122_maternal_imprinting1.18079754
77MP0000604_amyloidosis1.17300081
78MP0004924_abnormal_behavior1.16007562
79MP0005386_behavior/neurological_phenoty1.16007562
80MP0002909_abnormal_adrenal_gland1.14759024
81MP0001756_abnormal_urination1.13695291
82MP0002063_abnormal_learning/memory/cond1.13335831
83MP0005164_abnormal_response_to1.12077256
84MP0009785_altered_susceptibility_to1.11769911
85MP0008260_abnormal_autophagy1.10534409
86MP0000343_altered_response_to1.09938540
87MP0004019_abnormal_vitamin_homeostasis1.08716288
88MP0001664_abnormal_digestion1.08700364
89MP0010329_abnormal_lipoprotein_level1.08551831
90MP0004043_abnormal_pH_regulation1.08207680
91MP0003632_abnormal_nervous_system1.06977800
92MP0001324_abnormal_eye_pigmentation1.06975085
93MP0000778_abnormal_nervous_system1.05561017
94MP0002229_neurodegeneration1.05446943
95MP0002090_abnormal_vision1.03223551
96MP0003724_increased_susceptibility_to1.03206642
97MP0004134_abnormal_chest_morphology1.02395791
98MP0004272_abnormal_basement_membrane0.99242554
99MP0000647_abnormal_sebaceous_gland0.99174561
100MP0005085_abnormal_gallbladder_physiolo0.98558835
101MP0001485_abnormal_pinna_reflex0.97823036
102MP0006082_CNS_inflammation0.96081736
103MP0001963_abnormal_hearing_physiology0.95765448
104MP0008872_abnormal_physiological_respon0.95374919
105MP0002282_abnormal_trachea_morphology0.94922762
106MP0002653_abnormal_ependyma_morphology0.94849171
107MP0004885_abnormal_endolymph0.93277097
108MP0003011_delayed_dark_adaptation0.92637413
109MP0003186_abnormal_redox_activity0.92546999
110MP0005253_abnormal_eye_physiology0.91370160
111MP0005451_abnormal_body_composition0.91331400
112MP0005410_abnormal_fertilization0.90879708
113MP0001919_abnormal_reproductive_system0.90387445
114MP0002148_abnormal_hypersensitivity_rea0.89926587
115MP0000639_abnormal_adrenal_gland0.89647659
116MP0000538_abnormal_urinary_bladder0.89449141
117MP0002822_catalepsy0.88932486
118MP0002557_abnormal_social/conspecific_i0.88919942
119MP0005319_abnormal_enzyme/_coenzyme0.88711791
120MP0003806_abnormal_nucleotide_metabolis0.87171739
121MP0003191_abnormal_cellular_cholesterol0.87119131
122MP0005365_abnormal_bile_salt0.86946615
123MP0001853_heart_inflammation0.84905032
124MP0008469_abnormal_protein_level0.84589145
125MP0005310_abnormal_salivary_gland0.84530554
126MP0003631_nervous_system_phenotype0.84259986
127MP0003252_abnormal_bile_duct0.83930107
128MP0002693_abnormal_pancreas_physiology0.83715476
129MP0004858_abnormal_nervous_system0.83363307
130MP0002095_abnormal_skin_pigmentation0.83306979
131MP0000462_abnormal_digestive_system0.82504355
132MP0001661_extended_life_span0.82453934
133MP0000026_abnormal_inner_ear0.82011814
134MP0001188_hyperpigmentation0.81835251
135MP0002066_abnormal_motor_capabilities/c0.81649285
136MP0002332_abnormal_exercise_endurance0.80982346
137MP0005376_homeostasis/metabolism_phenot0.80724017
138MP0005535_abnormal_body_temperature0.80082080
139MP0003195_calcinosis0.78943850
140MP0005394_taste/olfaction_phenotype0.78377022
141MP0005499_abnormal_olfactory_system0.78377022
142MP0002882_abnormal_neuron_morphology0.78335699
143MP0000358_abnormal_cell_content/0.77215563
144MP0004883_abnormal_blood_vessel0.76946621
145MP0000013_abnormal_adipose_tissue0.76920450
146MP0003183_abnormal_peptide_metabolism0.76894017
147MP0010030_abnormal_orbit_morphology0.76888767
148MP0006036_abnormal_mitochondrial_physio0.76207112
149MP0004133_heterotaxia0.75539915
150MP0000230_abnormal_systemic_arterial0.73813336
151MP0001346_abnormal_lacrimal_gland0.73608598
152MP0002752_abnormal_somatic_nervous0.72139122
153MP0005636_abnormal_mineral_homeostasis0.72102990
154MP0005389_reproductive_system_phenotype0.70824470
155MP0009764_decreased_sensitivity_to0.70780941
156MP0005584_abnormal_enzyme/coenzyme_acti0.70520252
157MP0002928_abnormal_bile_duct0.69102705
158MP0000569_abnormal_digit_pigmentation0.69080404
159MP0005395_other_phenotype0.68462610
160MP0008873_increased_physiological_sensi0.68162525
161MP0003638_abnormal_response/metabolism_0.67305182
162MP0009643_abnormal_urine_homeostasis0.67304609
163MP0002254_reproductive_system_inflammat0.65116952

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.27078738
2Mitochondrial inheritance (HP:0001427)4.71171951
3Abnormal mitochondria in muscle tissue (HP:0008316)4.54855733
4Progressive macrocephaly (HP:0004481)4.40791763
5Acute encephalopathy (HP:0006846)4.31580991
6Neurofibrillary tangles (HP:0002185)4.26605335
7Parakeratosis (HP:0001036)4.17347550
8Renal Fanconi syndrome (HP:0001994)4.09211816
9Hepatocellular necrosis (HP:0001404)4.05784146
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.95940539
11Increased hepatocellular lipid droplets (HP:0006565)3.76128580
12Increased CSF lactate (HP:0002490)3.74480435
13Generalized aminoaciduria (HP:0002909)3.47470405
14Hepatic necrosis (HP:0002605)3.43510033
15Type I transferrin isoform profile (HP:0003642)3.37608548
16Lipid accumulation in hepatocytes (HP:0006561)3.36843710
17Leukodystrophy (HP:0002415)3.07514218
18Abnormality of glycolysis (HP:0004366)3.02806975
19Increased serum pyruvate (HP:0003542)3.02806975
203-Methylglutaconic aciduria (HP:0003535)3.00005438
21Hypothermia (HP:0002045)2.98945180
22Abnormal protein glycosylation (HP:0012346)2.98922779
23Abnormal glycosylation (HP:0012345)2.98922779
24Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.98922779
25Abnormal protein N-linked glycosylation (HP:0012347)2.98922779
26Congenital ichthyosiform erythroderma (HP:0007431)2.98787855
27Limb dystonia (HP:0002451)2.90397452
28Cerebral inclusion bodies (HP:0100314)2.88778707
29Abnormality of renal resorption (HP:0011038)2.86175988
30Optic disc pallor (HP:0000543)2.77187177
31Respiratory failure (HP:0002878)2.75865230
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72502483
33Retinal dysplasia (HP:0007973)2.69038890
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65488243
35Neuroendocrine neoplasm (HP:0100634)2.64844585
36Cerebral edema (HP:0002181)2.63698235
37Pancreatic cysts (HP:0001737)2.61001312
38Reduced antithrombin III activity (HP:0001976)2.57746160
39Pheochromocytoma (HP:0002666)2.56508546
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54462157
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.54462157
42Lethargy (HP:0001254)2.54193030
43Pancreatic fibrosis (HP:0100732)2.51965615
44Congenital, generalized hypertrichosis (HP:0004540)2.51396136
45Medial flaring of the eyebrow (HP:0010747)2.50528505
46Cerebral hemorrhage (HP:0001342)2.49093305
47Renal cortical cysts (HP:0000803)2.43980302
48Gait imbalance (HP:0002141)2.42417568
49Increased intramyocellular lipid droplets (HP:0012240)2.42374737
50Exercise intolerance (HP:0003546)2.39671627
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38116395
52Vaginal atresia (HP:0000148)2.37381530
53Exertional dyspnea (HP:0002875)2.36319950
54Congenital primary aphakia (HP:0007707)2.35805967
55Vacuolated lymphocytes (HP:0001922)2.35231531
56Genital tract atresia (HP:0001827)2.34890233
57Nausea (HP:0002018)2.30137533
58Lactic acidosis (HP:0003128)2.28805959
59Molar tooth sign on MRI (HP:0002419)2.27531079
60Abnormality of midbrain morphology (HP:0002418)2.27531079
61Supranuclear gaze palsy (HP:0000605)2.26351076
62Hypoplastic left heart (HP:0004383)2.25625880
63Hypoglycemic coma (HP:0001325)2.25162668
64Nephrogenic diabetes insipidus (HP:0009806)2.21809658
65Aplasia/hypoplasia of the uterus (HP:0008684)2.21254735
66Synostosis involving the elbow (HP:0003938)2.17309644
67Humeroradial synostosis (HP:0003041)2.17309644
68Spastic paraparesis (HP:0002313)2.17244158
69Abnormality of the axillary hair (HP:0100134)2.15380107
70Abnormality of secondary sexual hair (HP:0009888)2.15380107
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14418720
72True hermaphroditism (HP:0010459)2.14156340
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12482300
74Tongue fasciculations (HP:0001308)2.10483247
75Autoamputation (HP:0001218)2.09580065
76X-linked dominant inheritance (HP:0001423)2.08089437
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06646620
78Dicarboxylic aciduria (HP:0003215)2.06646620
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05409486
80Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05409486
81Hyperglycinemia (HP:0002154)2.04015988
82Hyperalaninemia (HP:0003348)1.99982612
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99982612
84Abnormality of alanine metabolism (HP:0010916)1.99982612
85Sensory axonal neuropathy (HP:0003390)1.99696757
86Aplastic anemia (HP:0001915)1.99618169
87Abnormality of vitamin B metabolism (HP:0004340)1.96774201
88Abnormality of the renal cortex (HP:0011035)1.96263969
89Degeneration of anterior horn cells (HP:0002398)1.96259141
90Abnormality of the anterior horn cell (HP:0006802)1.96259141
91Nephronophthisis (HP:0000090)1.95599978
92Increased muscle lipid content (HP:0009058)1.94345084
93Abnormality of methionine metabolism (HP:0010901)1.93731309
94Glycosuria (HP:0003076)1.92904208
95Abnormality of urine glucose concentration (HP:0011016)1.92904208
96Delayed gross motor development (HP:0002194)1.92614136
97Testicular atrophy (HP:0000029)1.92039187
98Hypoplastic pelvis (HP:0008839)1.91954071
99Abnormality of serum amino acid levels (HP:0003112)1.90929833
100Increased serum lactate (HP:0002151)1.89679052
101Sparse eyelashes (HP:0000653)1.89649164
102Hypoplastic heart (HP:0001961)1.89405565
103Split foot (HP:0001839)1.89243456
104Patchy hypopigmentation of hair (HP:0011365)1.87098590
105Abnormal pupillary function (HP:0007686)1.86545022
106Increased neuronal autofluorescent lipopigment (HP:0002074)1.86452864
107Progressive neurologic deterioration (HP:0002344)1.85553452
108Abnormal ciliary motility (HP:0012262)1.83846029
109Respiratory difficulties (HP:0002880)1.83819441
110Palpitations (HP:0001962)1.82261291
111Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81010116
112Delayed CNS myelination (HP:0002188)1.80689090
113Abnormal autonomic nervous system physiology (HP:0012332)1.77752278
114Methylmalonic aciduria (HP:0012120)1.75738954
115CNS demyelination (HP:0007305)1.74939212
116Muscle fibrillation (HP:0010546)1.73986419
117Delusions (HP:0000746)1.73535196
118Emotional lability (HP:0000712)1.72971252
119Prolonged neonatal jaundice (HP:0006579)1.72412888
120Abnormal respiratory motile cilium physiology (HP:0012261)1.71377533
121Blindness (HP:0000618)1.71347797
122Methylmalonic acidemia (HP:0002912)1.70803689
123Paralysis (HP:0003470)1.69407686
124Short tibia (HP:0005736)1.69208428
125Hypokinesia (HP:0002375)1.68695667
126Abnormal number of erythroid precursors (HP:0012131)1.68038689
127Focal motor seizures (HP:0011153)1.67604428
128Hyperphosphaturia (HP:0003109)1.67045638
129Cerebral hypomyelination (HP:0006808)1.66269812
130Symphalangism affecting the phalanges of the hand (HP:0009773)1.66148247
131Hypomagnesemia (HP:0002917)1.65982521
132Decreased electroretinogram (ERG) amplitude (HP:0000654)1.64883801
133Atonic seizures (HP:0010819)1.64032549
134Congenital stationary night blindness (HP:0007642)1.63722784
135Bile duct proliferation (HP:0001408)1.63179669
136Abnormal biliary tract physiology (HP:0012439)1.63179669
137Hypoplasia of the uterus (HP:0000013)1.62972965
138Aplasia/Hypoplasia of the lens (HP:0008063)1.62383584
139Peripheral hypomyelination (HP:0007182)1.62075497
140Metaphyseal dysplasia (HP:0100255)1.61611507
141Sensorimotor neuropathy (HP:0007141)1.61610603
142Abnormality of macrophages (HP:0004311)1.60105705
143Aplasia of the phalanges of the hand (HP:0009802)1.59791078
144Aplasia involving bones of the extremities (HP:0009825)1.59791078
145Aplasia involving bones of the upper limbs (HP:0009823)1.59791078
146Brushfield spots (HP:0001088)1.59602256
147Abnormality of placental membranes (HP:0011409)1.59439595
148Amniotic constriction ring (HP:0009775)1.59439595
149Abnormality of dentin (HP:0010299)1.58854092
150White forelock (HP:0002211)1.58822265
151Irregular vertebral endplates (HP:0003301)1.58611918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.62627027
2STK393.37326913
3ARAF3.06155432
4MAP3K122.91876371
5MST42.91812428
6PBK2.68824338
7MAPKAPK52.67978095
8OXSR12.56509287
9MAP4K22.39041140
10CASK2.20120788
11PDK22.18581228
12NUAK12.16656139
13TRIM282.02669438
14EIF2AK12.01495978
15ZAK1.97984609
16MYLK1.94710746
17BCR1.94468873
18FRK1.93603381
19STK161.92533086
20TNIK1.88847386
21ADRBK21.80282511
22WNK41.80238873
23MAPK151.75629513
24TESK11.68730121
25PNCK1.68599908
26GRK71.66693504
27BMPR1B1.65099372
28NME21.63307691
29NME11.61476199
30MUSK1.60647229
31EPHA41.59420593
32PIM21.49745844
33BMPR21.46782514
34CDK191.41176901
35CSNK1G31.40899009
36LIMK11.39411064
37MAP2K71.38772408
38PKN11.34245628
39EPHB11.31528286
40PINK11.29451188
41ERBB31.29357767
42PLK31.24243181
43MAP3K131.23476285
44NTRK11.22688407
45GRK51.22188942
46BRAF1.21316901
47CAMK2B1.21001838
48TESK21.19921533
49TLK11.13622601
50PRKCE1.12411239
51MET1.11864303
52NEK61.10620260
53MAPK131.09889098
54CAMK2D1.08464378
55MOS1.07746300
56CAMK2A1.07081513
57MAP3K31.06600367
58ACVR1B1.04672401
59CAMK2G0.99198633
60ADRBK10.97632058
61DYRK20.95657720
62ROCK20.94716846
63CSNK1G20.93915351
64RIPK40.89975124
65FGR0.89851912
66WEE10.89042648
67PLK20.88123491
68WNK30.87270121
69CSNK1G10.87014832
70PAK40.86251633
71TAOK30.82562228
72MAPKAPK30.81544792
73MAP3K140.75920901
74TAF10.75289107
75FLT30.72404750
76VRK10.72080970
77SIK30.71920651
78CAMKK20.71159802
79UHMK10.69930762
80PIK3CG0.69584943
81CDK80.68986397
82BCKDK0.66925379
83BRSK20.66550421
84ABL20.66147237
85BUB10.66066531
86TIE10.65681378
87INSRR0.65621446
88DAPK10.64553466
89MAP2K60.64407793
90SGK4940.64363092
91SGK2230.64363092
92MST1R0.63882328
93TGFBR10.61522139
94PRKCG0.60249269
95MAP3K20.59705856
96KDR0.59323227
97FES0.58545481
98PAK30.58403881
99MAP2K20.57023773
100EIF2AK30.56785815
101TSSK60.56141358
102PRKCQ0.55902825
103TXK0.55669771
104MAP3K40.55393995
105CDK30.54215401
106CDK140.53812292
107GRK10.53792858
108NTRK30.53413398
109TNK20.52865105
110PASK0.52143483
111EPHA30.51823191
112IKBKB0.51730902
113CDK50.51253719
114DAPK30.51159913
115PRKACA0.51054540
116MAPK120.49996027
117FER0.49402042
118CSNK1A1L0.49243284
119PIK3CA0.49205570
120OBSCN0.49150799
121NTRK20.49063236
122ERBB40.47863193
123CDK180.45632111
124CDK150.45426466
125CSNK2A10.44670718
126ILK0.44492844
127EPHB20.43933859
128SRPK10.43557016
129CSNK2A20.42117243
130NEK10.42102683
131PRKCI0.41784970
132CDK11A0.41770011
133PTK2B0.41536786
134YES10.40979049
135TGFBR20.40784436
136PHKG20.39836699
137PHKG10.39836699
138PRKCD0.37120389
139PRKCA0.36957182
140PLK10.36846525
141PRKG10.36630733
142RPS6KA50.36175932
143EIF2AK20.33037588

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.21506361
2Protein export_Homo sapiens_hsa030604.10473512
3Parkinsons disease_Homo sapiens_hsa050124.06039946
4Alzheimers disease_Homo sapiens_hsa050103.21144435
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.14006277
6Fatty acid elongation_Homo sapiens_hsa000622.92676921
7Huntingtons disease_Homo sapiens_hsa050162.66163214
8Proteasome_Homo sapiens_hsa030502.64804338
9Steroid biosynthesis_Homo sapiens_hsa001002.55966321
10Collecting duct acid secretion_Homo sapiens_hsa049662.55521946
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.48453355
12Ribosome_Homo sapiens_hsa030102.27078060
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24064428
14Sulfur metabolism_Homo sapiens_hsa009202.08406447
15Vibrio cholerae infection_Homo sapiens_hsa051102.07445881
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89739762
17Ether lipid metabolism_Homo sapiens_hsa005651.78883713
18Rheumatoid arthritis_Homo sapiens_hsa053231.69242844
19Sphingolipid metabolism_Homo sapiens_hsa006001.64901053
20Cardiac muscle contraction_Homo sapiens_hsa042601.62671124
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49810670
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48945882
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48005886
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.44656203
25Homologous recombination_Homo sapiens_hsa034401.40958035
26RNA polymerase_Homo sapiens_hsa030201.40666622
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40390266
28Histidine metabolism_Homo sapiens_hsa003401.33862591
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31656297
30Basal transcription factors_Homo sapiens_hsa030221.29557426
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24564934
32Serotonergic synapse_Homo sapiens_hsa047261.24168814
33Mismatch repair_Homo sapiens_hsa034301.21076388
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19228667
35Synaptic vesicle cycle_Homo sapiens_hsa047211.18604881
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17362503
37Nicotine addiction_Homo sapiens_hsa050331.13950073
38Phagosome_Homo sapiens_hsa041451.10305265
39Linoleic acid metabolism_Homo sapiens_hsa005911.09536341
40N-Glycan biosynthesis_Homo sapiens_hsa005101.04519934
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01257597
42Nucleotide excision repair_Homo sapiens_hsa034200.99428366
43GABAergic synapse_Homo sapiens_hsa047270.98993130
44Arachidonic acid metabolism_Homo sapiens_hsa005900.97525450
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95452162
46Tryptophan metabolism_Homo sapiens_hsa003800.95216935
47Lysosome_Homo sapiens_hsa041420.94021099
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93274897
49Tyrosine metabolism_Homo sapiens_hsa003500.93121985
50Cocaine addiction_Homo sapiens_hsa050300.88695551
51Sulfur relay system_Homo sapiens_hsa041220.88139088
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87160722
53Glutathione metabolism_Homo sapiens_hsa004800.86533757
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85435078
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84905265
56Phenylalanine metabolism_Homo sapiens_hsa003600.83184262
57Other glycan degradation_Homo sapiens_hsa005110.81645669
58Metabolic pathways_Homo sapiens_hsa011000.79901370
59RNA degradation_Homo sapiens_hsa030180.79553106
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78723293
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77953609
62Fanconi anemia pathway_Homo sapiens_hsa034600.77906668
63Arginine and proline metabolism_Homo sapiens_hsa003300.77641148
64Retinol metabolism_Homo sapiens_hsa008300.76154995
65Regulation of autophagy_Homo sapiens_hsa041400.75780211
66Nitrogen metabolism_Homo sapiens_hsa009100.74128323
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.73276843
68Peroxisome_Homo sapiens_hsa041460.72990667
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72969849
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72828453
71One carbon pool by folate_Homo sapiens_hsa006700.70375481
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68893245
73Folate biosynthesis_Homo sapiens_hsa007900.68277199
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.68204529
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67668101
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67609730
77Butanoate metabolism_Homo sapiens_hsa006500.65058584
78Malaria_Homo sapiens_hsa051440.63352858
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62906567
80Caffeine metabolism_Homo sapiens_hsa002320.62732199
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60951508
82Autoimmune thyroid disease_Homo sapiens_hsa053200.60601389
83Selenocompound metabolism_Homo sapiens_hsa004500.59440584
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59273331
85Base excision repair_Homo sapiens_hsa034100.59105624
86Pyruvate metabolism_Homo sapiens_hsa006200.57402957
87Morphine addiction_Homo sapiens_hsa050320.57289287
88Propanoate metabolism_Homo sapiens_hsa006400.55943672
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55531644
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55263691
91Non-homologous end-joining_Homo sapiens_hsa034500.55162350
92Phototransduction_Homo sapiens_hsa047440.53449286
93Glutamatergic synapse_Homo sapiens_hsa047240.52959285
94Graft-versus-host disease_Homo sapiens_hsa053320.51013767
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.50943770
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50812103
97Long-term depression_Homo sapiens_hsa047300.48566159
98Taste transduction_Homo sapiens_hsa047420.47999500
99RNA transport_Homo sapiens_hsa030130.47621723
100Pancreatic secretion_Homo sapiens_hsa049720.47497316
101Allograft rejection_Homo sapiens_hsa053300.47106681
102Spliceosome_Homo sapiens_hsa030400.46429303
103Type I diabetes mellitus_Homo sapiens_hsa049400.44806280
104Carbon metabolism_Homo sapiens_hsa012000.42604015
105Fatty acid degradation_Homo sapiens_hsa000710.41761583
106DNA replication_Homo sapiens_hsa030300.41438988
107Vitamin B6 metabolism_Homo sapiens_hsa007500.41015938
108Amphetamine addiction_Homo sapiens_hsa050310.39392465
109African trypanosomiasis_Homo sapiens_hsa051430.38821088
110Mineral absorption_Homo sapiens_hsa049780.37954735
111Fatty acid metabolism_Homo sapiens_hsa012120.36447004
112Dopaminergic synapse_Homo sapiens_hsa047280.36196312
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.35685583
114Chemical carcinogenesis_Homo sapiens_hsa052040.35510465
115beta-Alanine metabolism_Homo sapiens_hsa004100.35188381
116Axon guidance_Homo sapiens_hsa043600.35056485
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.35042298
118Legionellosis_Homo sapiens_hsa051340.34871166
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34599712
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34158451
121Insulin secretion_Homo sapiens_hsa049110.33848905
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33484920
123Salivary secretion_Homo sapiens_hsa049700.32642896
124Fat digestion and absorption_Homo sapiens_hsa049750.32578730
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32408237
126Galactose metabolism_Homo sapiens_hsa000520.31766074
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29997534
128Asthma_Homo sapiens_hsa053100.29436085
129Circadian entrainment_Homo sapiens_hsa047130.28732926
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.28407923
131Calcium signaling pathway_Homo sapiens_hsa040200.28340282
132Ovarian steroidogenesis_Homo sapiens_hsa049130.28115549
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26003469
134Vitamin digestion and absorption_Homo sapiens_hsa049770.25993466
135Purine metabolism_Homo sapiens_hsa002300.25041193
136Cholinergic synapse_Homo sapiens_hsa047250.23790212
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.23402697
138Pyrimidine metabolism_Homo sapiens_hsa002400.23203690
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22935673
140Prion diseases_Homo sapiens_hsa050200.21969798
141Gastric acid secretion_Homo sapiens_hsa049710.20238943
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.19974065
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19044300

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