SDF2L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.45494895
2Golgi transport vesicle coating (GO:0048200)8.45494895
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)8.14044459
4signal peptide processing (GO:0006465)7.56136570
5protein retention in ER lumen (GO:0006621)7.11703311
6protein maturation by protein folding (GO:0022417)5.87921343
7exocrine pancreas development (GO:0031017)5.52380451
8activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.32919914
9positive regulation of nuclease activity (GO:0032075)5.26562558
10sequestering of metal ion (GO:0051238)5.11689222
11ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)5.09086200
12COPII vesicle coating (GO:0048208)5.01127589
13regulation of nuclease activity (GO:0032069)4.91323200
14endoplasmic reticulum unfolded protein response (GO:0030968)4.76811652
15regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.70036576
16cellular response to unfolded protein (GO:0034620)4.64142989
17proteasome assembly (GO:0043248)4.64029605
18cellular response to topologically incorrect protein (GO:0035967)4.49945838
19retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.48468223
20protein N-linked glycosylation via asparagine (GO:0018279)4.43979221
21peptidyl-asparagine modification (GO:0018196)4.38786522
22ER-nucleus signaling pathway (GO:0006984)4.38638224
23GDP-mannose metabolic process (GO:0019673)4.21368209
24response to endoplasmic reticulum stress (GO:0034976)4.09057311
25protein N-linked glycosylation (GO:0006487)4.06900897
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06422687
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06422687
28DNA deamination (GO:0045006)4.04507639
29ribosomal small subunit biogenesis (GO:0042274)4.03958966
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.92950636
31proline biosynthetic process (GO:0006561)3.72077204
32regulation of cellular amino acid metabolic process (GO:0006521)3.69587075
33antigen processing and presentation of endogenous antigen (GO:0019883)3.69307656
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.68227427
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65339230
36ATP synthesis coupled proton transport (GO:0015986)3.63504223
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.63504223
38folic acid-containing compound biosynthetic process (GO:0009396)3.61769985
39response to unfolded protein (GO:0006986)3.56544094
40protein targeting to ER (GO:0045047)3.55406071
41regulation of mitochondrial translation (GO:0070129)3.55270651
42ER overload response (GO:0006983)3.53819444
43pseudouridine synthesis (GO:0001522)3.52665330
44cotranslational protein targeting to membrane (GO:0006613)3.52390302
45respiratory electron transport chain (GO:0022904)3.51770544
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.49767341
47negative regulation of ligase activity (GO:0051352)3.49767341
48response to topologically incorrect protein (GO:0035966)3.46587260
49cell redox homeostasis (GO:0045454)3.46531955
50endocrine pancreas development (GO:0031018)3.46512153
51electron transport chain (GO:0022900)3.42144215
52protein localization to endoplasmic reticulum (GO:0070972)3.39408772
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.38107652
54negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.38041693
55establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38006978
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.37087197
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35811568
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33427641
59mitochondrial calcium ion transport (GO:0006851)3.31389703
60UDP-N-acetylglucosamine metabolic process (GO:0006047)3.31335237
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.31169587
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.30378874
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.30378874
64oxidative phosphorylation (GO:0006119)3.30311120
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25767038
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25767038
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25767038
68respiratory burst (GO:0045730)3.24869035
69signal transduction involved in DNA damage checkpoint (GO:0072422)3.23617024
70signal transduction involved in DNA integrity checkpoint (GO:0072401)3.23617024
71peptide hormone processing (GO:0016486)3.23367224
72vesicle coating (GO:0006901)3.22820133
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22771810
74pteridine-containing compound biosynthetic process (GO:0042559)3.22556681
75intestinal cholesterol absorption (GO:0030299)3.20731513
76DNA strand elongation (GO:0022616)3.17538280
77nucleobase-containing small molecule interconversion (GO:0015949)3.16970472
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16736105
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15618118
80chaperone-mediated protein transport (GO:0072321)3.14559366
81signal transduction involved in cell cycle checkpoint (GO:0072395)3.13945422
82disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.11349579
83killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.11349579
84protein targeting to mitochondrion (GO:0006626)3.11187053
85neutrophil mediated immunity (GO:0002446)3.09516881
86positive regulation of ligase activity (GO:0051351)3.05231760
87ribonucleoprotein complex biogenesis (GO:0022613)3.04743979
88reactive oxygen species biosynthetic process (GO:1903409)3.03667793
894-hydroxyproline metabolic process (GO:0019471)3.02913467
90deoxyribonucleotide catabolic process (GO:0009264)2.99370351
91maturation of SSU-rRNA (GO:0030490)2.97732433
92regulation of type B pancreatic cell apoptotic process (GO:2000674)2.96047201
93ribosome biogenesis (GO:0042254)2.95608897
94maintenance of protein localization in organelle (GO:0072595)2.93841547
95purine deoxyribonucleotide catabolic process (GO:0009155)2.92568585
96ER to Golgi vesicle-mediated transport (GO:0006888)2.91185772
97viral transcription (GO:0019083)2.90693359
98rRNA modification (GO:0000154)2.90506817
99deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.89551721
100negative regulation of myeloid cell apoptotic process (GO:0033033)2.88878035
101establishment of protein localization to mitochondrion (GO:0072655)2.88407466
102pentose metabolic process (GO:0019321)2.87314136
103deoxyribose phosphate catabolic process (GO:0046386)2.84839492
104negative regulation of B cell apoptotic process (GO:0002903)2.84671394
105regulation of ubiquitin-protein transferase activity (GO:0051438)2.84443086
106lipopolysaccharide biosynthetic process (GO:0009103)2.83943317
107guanosine-containing compound biosynthetic process (GO:1901070)2.81223211
108Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79017815
109cellular component biogenesis (GO:0044085)2.78610750
110regulation of cellular amine metabolic process (GO:0033238)2.78019909
1112-deoxyribonucleotide metabolic process (GO:0009394)2.77369914
112DNA replication checkpoint (GO:0000076)2.76388534
113protein autoprocessing (GO:0016540)2.76258083
114regulation of ligase activity (GO:0051340)2.76168036
115translational termination (GO:0006415)2.73020948
116pyrimidine nucleotide catabolic process (GO:0006244)2.71263394
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71189437
118mitochondrial respiratory chain complex I assembly (GO:0032981)2.71189437
119NADH dehydrogenase complex assembly (GO:0010257)2.71189437
120L-alpha-amino acid transmembrane transport (GO:1902475)2.70461303
121protein complex biogenesis (GO:0070271)2.69626801
122translation (GO:0006412)2.69470857
123positive regulation of cell cycle arrest (GO:0071158)2.67470508
124antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.67305706
125cellular response to interferon-beta (GO:0035458)2.66833007
126response to interferon-beta (GO:0035456)2.66718245
127neutrophil activation involved in immune response (GO:0002283)2.66285156
128establishment of protein localization to mitochondrial membrane (GO:0090151)2.65887679
129chaperone mediated protein folding requiring cofactor (GO:0051085)2.65314856
130deoxyribonucleotide biosynthetic process (GO:0009263)2.64530302
131nuclear envelope reassembly (GO:0031468)2.64508111
132mitotic nuclear envelope reassembly (GO:0007084)2.64508111
133protein localization to mitochondrion (GO:0070585)2.63815150
134pentose-phosphate shunt (GO:0006098)2.63392095
135ribosomal large subunit biogenesis (GO:0042273)2.62939830
136pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.62709449
137formation of translation preinitiation complex (GO:0001731)2.62158835
138translational elongation (GO:0006414)2.61997029
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.61906924
140deoxyribose phosphate metabolic process (GO:0019692)2.61861270
141transcription elongation from RNA polymerase III promoter (GO:0006385)2.61125125
142chaperone-mediated protein folding (GO:0061077)2.61029629
143peptide catabolic process (GO:0043171)2.60130430
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.59674274
145antigen processing and presentation via MHC class Ib (GO:0002475)2.59156470
146antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.58509712
147glandular epithelial cell differentiation (GO:0002067)2.57266838
148valine metabolic process (GO:0006573)2.54759276
149proline metabolic process (GO:0006560)2.52461265
150nucleotide-sugar metabolic process (GO:0009225)2.52056672
151dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.45588453
152myeloid leukocyte mediated immunity (GO:0002444)2.44864690
153deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.44396305
154deoxyribose phosphate biosynthetic process (GO:0046385)2.42959578
1552-deoxyribonucleotide biosynthetic process (GO:0009265)2.42959578
156regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42073849
157production of molecular mediator involved in inflammatory response (GO:0002532)2.39748184
158telomere maintenance via semi-conservative replication (GO:0032201)2.39593178
159apoptotic cell clearance (GO:0043277)2.39567196
160negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.38801031
161modulation of growth of symbiont involved in interaction with host (GO:0044144)2.38801031
162regulation of growth of symbiont in host (GO:0044126)2.38801031
163negative regulation of growth of symbiont in host (GO:0044130)2.38801031
164hydrogen peroxide biosynthetic process (GO:0050665)2.37791701
165negative regulation of glycoprotein biosynthetic process (GO:0010561)2.37481028
166nucleotide-sugar biosynthetic process (GO:0009226)2.37092289
167tetrahydrofolate metabolic process (GO:0046653)2.34599529
168DNA strand elongation involved in DNA replication (GO:0006271)2.33130165
169killing of cells of other organism (GO:0031640)2.33002570
170disruption of cells of other organism (GO:0044364)2.33002570
171protein targeting to membrane (GO:0006612)2.32845400
172response to peptidoglycan (GO:0032494)2.32218467
173ribosomal small subunit assembly (GO:0000028)2.32165926
174pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.30870005
175NADPH regeneration (GO:0006740)2.28972979
176Golgi organization (GO:0007030)2.28466557
177maternal placenta development (GO:0001893)2.28392027
178response to fungus (GO:0009620)2.27959008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.76380900
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.75473288
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21988525
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.05848954
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91772138
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65605691
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.60703490
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58098475
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40822305
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35515598
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.33270738
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.21041524
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11104517
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.10211285
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10082742
16MYC_22102868_ChIP-Seq_BL_Human2.08392890
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.01590946
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.01527643
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99443263
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99270946
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.96557634
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96386118
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95032455
24SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.94650488
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94460803
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92430062
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90031274
28ERG_20887958_ChIP-Seq_HPC-7_Mouse1.85747508
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85315071
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84014777
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.82716260
32VDR_21846776_ChIP-Seq_THP-1_Human1.81917129
33VDR_23849224_ChIP-Seq_CD4+_Human1.81508269
34GATA1_22025678_ChIP-Seq_K562_Human1.80909785
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79515249
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.77721250
37ZNF263_19887448_ChIP-Seq_K562_Human1.73619491
38SPI1_23547873_ChIP-Seq_NB4_Human1.72582400
39GABP_19822575_ChIP-Seq_HepG2_Human1.70119613
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.69829423
41* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68790126
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67865509
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67365666
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67244418
45DCP1A_22483619_ChIP-Seq_HELA_Human1.65065265
46* LXR_22292898_ChIP-Seq_THP-1_Human1.57435528
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53944247
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53638504
49TFEB_21752829_ChIP-Seq_HELA_Human1.51653296
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50824837
51FOXP3_21729870_ChIP-Seq_TREG_Human1.50661617
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49060309
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48708093
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47654460
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46849062
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46605565
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.45656255
58XRN2_22483619_ChIP-Seq_HELA_Human1.45185111
59* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43729341
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43551929
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43243348
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42871586
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42775648
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42380256
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.41703573
66* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40946010
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40183021
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37872808
69MYB_26560356_Chip-Seq_TH2_Human1.34715650
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.34006443
71VDR_24763502_ChIP-Seq_THP-1_Human1.33578071
72KDM5A_27292631_Chip-Seq_BREAST_Human1.33431350
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32898710
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.32851889
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32110424
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.32011278
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31430568
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.29539295
79* NCOR1_26117541_ChIP-Seq_K562_Human1.29135242
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.28654132
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28638324
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27489000
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26156490
84P68_20966046_ChIP-Seq_HELA_Human1.25870008
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.25179599
86BCL6_27268052_Chip-Seq_Bcells_Human1.23850695
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22869344
88* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22769675
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22040762
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21195489
91CIITA_25753668_ChIP-Seq_RAJI_Human1.19717603
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.19284504
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18903957
94MYB_26560356_Chip-Seq_TH1_Human1.18672008
95ELK1_19687146_ChIP-ChIP_HELA_Human1.18610168
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18369855
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17854603
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16831173
99MAF_26560356_Chip-Seq_TH2_Human1.16671953
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15866332
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15409505
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14949813
103BCOR_27268052_Chip-Seq_Bcells_Human1.14682333
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12269298
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11840670
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10765539
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10023700
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.09882302
109FOXM1_23109430_ChIP-Seq_U2OS_Human1.09749511
110UTX_26944678_Chip-Seq_JUKART_Human1.09162622
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08847739
112RACK7_27058665_Chip-Seq_MCF-7_Human1.08252148
113E2F1_21310950_ChIP-Seq_MCF-7_Human1.07768978
114SCL_19346495_ChIP-Seq_HPC-7_Human1.07552590
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07373918
116MAF_26560356_Chip-Seq_TH1_Human1.07127718
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07060451
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06357267
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05905285
120THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05864828
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04823719
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04757490
123* FOXP1_21924763_ChIP-Seq_HESCs_Human1.02998158
124* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02585435
125CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02301855
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01096706
127PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01013122
128* SA1_27219007_Chip-Seq_ERYTHROID_Human1.00692920
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00033047
130TTF2_22483619_ChIP-Seq_HELA_Human0.99334854
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97267918
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97053506
133TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96514648
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95878349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005220_abnormal_exocrine_pancreas3.40996859
2MP0005451_abnormal_body_composition3.35041630
3MP0002693_abnormal_pancreas_physiology3.01338242
4MP0003693_abnormal_embryo_hatching2.91100926
5MP0002877_abnormal_melanocyte_morpholog2.76362547
6MP0003183_abnormal_peptide_metabolism2.60004680
7MP0001835_abnormal_antigen_presentation2.55071562
8MP0005058_abnormal_lysosome_morphology2.55036666
9MP0001944_abnormal_pancreas_morphology2.42957483
10MP0003436_decreased_susceptibility_to2.38967561
11MP0001666_abnormal_nutrient_absorption2.37633138
12MP0003786_premature_aging2.37395330
13MP0005365_abnormal_bile_salt2.36759832
14MP0005083_abnormal_biliary_tract2.35407666
15MP0003111_abnormal_nucleus_morphology2.30856990
16MP0006054_spinal_hemorrhage1.93745024
17MP0002139_abnormal_hepatobiliary_system1.91379144
18MP0003300_gastrointestinal_ulcer1.91138017
19MP0004264_abnormal_extraembryonic_tissu1.87213146
20MP0005671_abnormal_response_to1.86936147
21MP0005000_abnormal_immune_tolerance1.85014053
22MP0003195_calcinosis1.84511754
23MP0003172_abnormal_lysosome_physiology1.81488747
24MP0008007_abnormal_cellular_replicative1.79385492
25MP0005025_abnormal_response_to1.77267408
26MP0004043_abnormal_pH_regulation1.77188113
27MP0010094_abnormal_chromosome_stability1.75586212
28MP0002419_abnormal_innate_immunity1.75180374
29MP0005310_abnormal_salivary_gland1.74951037
30MP0009840_abnormal_foam_cell1.74866350
31MP0003303_peritoneal_inflammation1.73061793
32MP0002132_abnormal_respiratory_system1.72817942
33MP0006035_abnormal_mitochondrial_morpho1.72240937
34MP0000343_altered_response_to1.65361846
35MP0000685_abnormal_immune_system1.63881086
36MP0001845_abnormal_inflammatory_respons1.63784560
37MP0002148_abnormal_hypersensitivity_rea1.62400661
38MP0009785_altered_susceptibility_to1.60479401
39MP0003077_abnormal_cell_cycle1.60461108
40MP0001790_abnormal_immune_system1.60138344
41MP0005387_immune_system_phenotype1.60138344
42MP0005397_hematopoietic_system_phenotyp1.59915193
43MP0001545_abnormal_hematopoietic_system1.59915193
44MP0009643_abnormal_urine_homeostasis1.57926203
45MP0002166_altered_tumor_susceptibility1.57271278
46MP0008932_abnormal_embryonic_tissue1.56580538
47MP0001727_abnormal_embryo_implantation1.55782409
48MP0009333_abnormal_splenocyte_physiolog1.55303686
49MP0003283_abnormal_digestive_organ1.54282001
50MP0003724_increased_susceptibility_to1.54002841
51MP0002723_abnormal_immune_serum1.52410651
52MP0000490_abnormal_crypts_of1.50345354
53MP0004147_increased_porphyrin_level1.50276583
54MP0001800_abnormal_humoral_immune1.46559358
55MP0002452_abnormal_antigen_presenting1.46361624
56MP0002420_abnormal_adaptive_immunity1.46095380
57MP0001819_abnormal_immune_cell1.44184314
58MP0005464_abnormal_platelet_physiology1.44004537
59MP0001661_extended_life_span1.40284386
60MP0003186_abnormal_redox_activity1.36285580
61MP0004957_abnormal_blastocyst_morpholog1.35562538
62MP0003866_abnormal_defecation1.35287582
63MP0002078_abnormal_glucose_homeostasis1.35219435
64MP0003763_abnormal_thymus_physiology1.35007738
65MP0000678_abnormal_parathyroid_gland1.33054551
66MP0008469_abnormal_protein_level1.31379470
67MP0003868_abnormal_feces_composition1.30683934
68MP0000858_altered_metastatic_potential1.28414328
69MP0008875_abnormal_xenobiotic_pharmacok1.26886541
70MP0010155_abnormal_intestine_physiology1.26349468
71MP0000313_abnormal_cell_death1.26218440
72MP0005360_urolithiasis1.25452698
73MP0009278_abnormal_bone_marrow1.24247197
74MP0010386_abnormal_urinary_bladder1.23880946
75MP0003656_abnormal_erythrocyte_physiolo1.23706786
76MP0005379_endocrine/exocrine_gland_phen1.22764604
77MP0002405_respiratory_system_inflammati1.21838643
78MP0001533_abnormal_skeleton_physiology1.21669870
79MP0006082_CNS_inflammation1.19092991
80MP0000716_abnormal_immune_system1.19035296
81MP0002398_abnormal_bone_marrow1.18159121
82MP0009697_abnormal_copulation1.16812573
83MP0002006_tumorigenesis1.16382939
84MP0004782_abnormal_surfactant_physiolog1.15199526
85MP0000613_abnormal_salivary_gland1.14085032
86MP0009379_abnormal_foot_pigmentation1.13325822
87MP0002928_abnormal_bile_duct1.12660197
88MP0005636_abnormal_mineral_homeostasis1.11589286
89MP0004947_skin_inflammation1.11339186
90MP0001873_stomach_inflammation1.11290169
91MP0000609_abnormal_liver_physiology1.09731129
92MP0003075_altered_response_to1.09573556
93MP0005084_abnormal_gallbladder_morpholo1.07537831
94MP0009764_decreased_sensitivity_to1.07300520
95MP0002429_abnormal_blood_cell1.07178901
96MP0000703_abnormal_thymus_morphology1.06054404
97MP0002396_abnormal_hematopoietic_system1.05578746
98MP0000689_abnormal_spleen_morphology1.05530290
99MP0001881_abnormal_mammary_gland1.04773551
100MP0005584_abnormal_enzyme/coenzyme_acti1.04202573
101MP0003718_maternal_effect1.03808008
102MP0005410_abnormal_fertilization1.03652748
103MP0005076_abnormal_cell_differentiation1.02429966
104MP0002909_abnormal_adrenal_gland1.01651986
105MP0005085_abnormal_gallbladder_physiolo1.01517890
106MP0002722_abnormal_immune_system1.00488598
107MP0001764_abnormal_homeostasis0.99325065
108MP0003191_abnormal_cellular_cholesterol0.98182856
109MP0003806_abnormal_nucleotide_metabolis0.97229707
110MP0002138_abnormal_hepatobiliary_system0.96103160
111MP0001765_abnormal_ion_homeostasis0.95985705
112MP0008260_abnormal_autophagy0.94694859
113MP0003959_abnormal_lean_body0.94333259
114MP0005408_hypopigmentation0.93608103
115MP0000598_abnormal_liver_morphology0.93596225
116MP0010307_abnormal_tumor_latency0.92273248
117MP0000681_abnormal_thyroid_gland0.91319628
118MP0001730_embryonic_growth_arrest0.90815153
119MP0005319_abnormal_enzyme/_coenzyme0.90109395
120MP0000465_gastrointestinal_hemorrhage0.89489846
121MP0003795_abnormal_bone_structure0.88052397
122MP0005332_abnormal_amino_acid0.88048536
123MP0001853_heart_inflammation0.87428566
124MP0005330_cardiomyopathy0.84846749
125MP0005165_increased_susceptibility_to0.84654621
126MP0003252_abnormal_bile_duct0.83484887
127MP0002019_abnormal_tumor_incidence0.83006958
128MP0001756_abnormal_urination0.82942871
129MP0008058_abnormal_DNA_repair0.82429377
130MP0000350_abnormal_cell_proliferation0.81547735
131MP0010352_gastrointestinal_tract_polyps0.81247277
132MP0004185_abnormal_adipocyte_glucose0.80443592
133MP0004510_myositis0.80059276
134MP0005501_abnormal_skin_physiology0.79122195
135MP0006036_abnormal_mitochondrial_physio0.78558724
136MP0008995_early_reproductive_senescence0.78292230
137MP0000358_abnormal_cell_content/0.77795684
138MP0000372_irregular_coat_pigmentation0.77773652
139MP0009642_abnormal_blood_homeostasis0.77321420
140MP0009763_increased_sensitivity_to0.76215581

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.71788728
2Vacuolated lymphocytes (HP:0001922)4.48824106
3Abnormal mitochondria in muscle tissue (HP:0008316)4.44904088
4Hypoglycemic seizures (HP:0002173)4.36464000
5Hyperinsulinemic hypoglycemia (HP:0000825)4.31754801
6Acute necrotizing encephalopathy (HP:0006965)4.25880502
7Dysostosis multiplex (HP:0000943)4.09391553
8Hyperthyroidism (HP:0000836)4.06711658
9Abnormal protein glycosylation (HP:0012346)4.01189067
10Abnormal glycosylation (HP:0012345)4.01189067
11Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.01189067
12Abnormal protein N-linked glycosylation (HP:0012347)4.01189067
13Type I transferrin isoform profile (HP:0003642)3.95367895
14Acute encephalopathy (HP:0006846)3.92289200
15Urinary glycosaminoglycan excretion (HP:0003541)3.88417607
16Mucopolysacchariduria (HP:0008155)3.88417607
17Hypertensive crisis (HP:0100735)3.83645329
18Mitochondrial inheritance (HP:0001427)3.77148975
19Abnormality of the intrinsic pathway (HP:0010989)3.76337425
20Symptomatic seizures (HP:0011145)3.69157950
21Increased CSF lactate (HP:0002490)3.54996061
22Truncus arteriosus (HP:0001660)3.52579282
23Reduced antithrombin III activity (HP:0001976)3.50472811
24Abnormality of polysaccharide metabolism (HP:0011012)3.50280891
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.50280891
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.50280891
27Hepatocellular necrosis (HP:0001404)3.46605321
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.42023673
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.42023673
30Thrombocytosis (HP:0001894)3.36324934
31Late onset (HP:0003584)3.31810420
32Seborrheic dermatitis (HP:0001051)3.31458939
33Generalized aminoaciduria (HP:0002909)3.25054833
34Progressive macrocephaly (HP:0004481)3.23268710
35Hepatic necrosis (HP:0002605)3.23114497
36Increased intramyocellular lipid droplets (HP:0012240)3.19010427
37Eczematoid dermatitis (HP:0000976)3.16523557
38Recurrent abscess formation (HP:0002722)3.12190307
39Abnormality of the pancreatic islet cells (HP:0006476)3.09890152
40Abnormality of endocrine pancreas physiology (HP:0012093)3.09890152
41Cholecystitis (HP:0001082)3.09792360
42Abnormal gallbladder physiology (HP:0012438)3.09792360
43Ragged-red muscle fibers (HP:0003200)3.07449532
44Increased muscle lipid content (HP:0009058)3.02199342
45Cerebral edema (HP:0002181)3.01227473
46Recurrent bacterial skin infections (HP:0005406)2.97288066
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89154314
48Abnormality of T cell physiology (HP:0011840)2.86419056
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.82882491
50Rough bone trabeculation (HP:0100670)2.78200980
51Abnormality of the common coagulation pathway (HP:0010990)2.76455648
52Recurrent gram-negative bacterial infections (HP:0005420)2.74815286
53Neoplasm of head and neck (HP:0012288)2.73968767
54Esophageal neoplasm (HP:0100751)2.73968767
55Renal Fanconi syndrome (HP:0001994)2.72420850
56Ketoacidosis (HP:0001993)2.69691757
57Lactic acidosis (HP:0003128)2.67380392
58Increased serum lactate (HP:0002151)2.61603560
59Lipid accumulation in hepatocytes (HP:0006561)2.55418598
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55373820
61Hypokinesia (HP:0002375)2.55201399
62Poor head control (HP:0002421)2.54328181
63Progressive neurologic deterioration (HP:0002344)2.51330396
64Increased hepatocellular lipid droplets (HP:0006565)2.49573319
65Aplastic anemia (HP:0001915)2.49503617
66Abnormality of glycolipid metabolism (HP:0010969)2.47286955
67Abnormality of liposaccharide metabolism (HP:0010968)2.47286955
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.47286955
69Exercise intolerance (HP:0003546)2.46148972
70IgM deficiency (HP:0002850)2.46004927
71Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45684452
72Thoracolumbar scoliosis (HP:0002944)2.44430401
73Abnormality of the tricuspid valve (HP:0001702)2.44164831
74Abnormality of cells of the erythroid lineage (HP:0012130)2.43821613
75Respiratory failure (HP:0002878)2.42019538
76Degeneration of anterior horn cells (HP:0002398)2.38272766
77Abnormality of the anterior horn cell (HP:0006802)2.38272766
78Elevated erythrocyte sedimentation rate (HP:0003565)2.37152372
79Recurrent viral infections (HP:0004429)2.36694754
80Nonimmune hydrops fetalis (HP:0001790)2.36655077
81Pancytopenia (HP:0001876)2.34271599
82Testicular atrophy (HP:0000029)2.33891693
83Hypoparathyroidism (HP:0000829)2.28720825
84Increased serum pyruvate (HP:0003542)2.28670823
85Abnormality of glycolysis (HP:0004366)2.26704464
86Abnormality of macrophages (HP:0004311)2.26563443
87Ketosis (HP:0001946)2.26282258
88Increased serum ferritin (HP:0003281)2.24722148
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23825648
90Abnormal trabecular bone morphology (HP:0100671)2.23637067
91Reticulocytopenia (HP:0001896)2.22530631
92Insulin-resistant diabetes mellitus (HP:0000831)2.21986608
933-Methylglutaconic aciduria (HP:0003535)2.21929698
94Aplasia/Hypoplasia of the thymus (HP:0010515)2.20004013
95Chronic otitis media (HP:0000389)2.18694032
96Pancreatic islet-cell hyperplasia (HP:0004510)2.17234907
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16369813
98Dicarboxylic aciduria (HP:0003215)2.16369813
99Progressive muscle weakness (HP:0003323)2.12261343
100Abnormality of reticulocytes (HP:0004312)2.12219812
101Hyperglycemia (HP:0003074)2.11789488
102Microvesicular hepatic steatosis (HP:0001414)2.11641495
103Large for gestational age (HP:0001520)2.11512868
104Insulin resistance (HP:0000855)2.09217522
105Increased neuronal autofluorescent lipopigment (HP:0002074)2.08928387
106Reticulocytosis (HP:0001923)2.07335740
107Exocrine pancreatic insufficiency (HP:0001738)2.06266577
108Periodontitis (HP:0000704)2.06253553
109Increased cerebral lipofuscin (HP:0011813)2.05901005
110Abnormality of subcutaneous fat tissue (HP:0001001)2.04684887
111Beaking of vertebral bodies (HP:0004568)2.03538223
112Systemic lupus erythematosus (HP:0002725)2.03053735
113Lethargy (HP:0001254)2.02793982
114Respiratory difficulties (HP:0002880)2.01941641
115Petechiae (HP:0000967)2.01907248
116Atelectasis (HP:0100750)2.00598539
117Abnormal pancreas size (HP:0012094)2.00527603
118Joint stiffness (HP:0001387)1.99169351
119Abnormality of T cells (HP:0002843)1.98791330
120Emotional lability (HP:0000712)1.98703864
121Pancreatitis (HP:0001733)1.97911064
122Recurrent bronchitis (HP:0002837)1.96733489
123Fat malabsorption (HP:0002630)1.96382662
124Interstitial pulmonary disease (HP:0006530)1.95266933
125Villous atrophy (HP:0011473)1.94936479
126Abnormality of small intestinal villus morphology (HP:0011472)1.94936479
127Nasal polyposis (HP:0100582)1.94625944
128Meningitis (HP:0001287)1.94449646
129Abnormality of the thoracic spine (HP:0100711)1.92893151
130Pallor (HP:0000980)1.92803966
131Oral leukoplakia (HP:0002745)1.89914007
132Recurrent skin infections (HP:0001581)1.89846056
133Microretrognathia (HP:0000308)1.89213102
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.88421130
135Nausea (HP:0002018)1.87935620
136Spastic paraparesis (HP:0002313)1.87427035
137Limb hypertonia (HP:0002509)1.87407331
138Thoracic kyphosis (HP:0002942)1.85660705
139Progressive microcephaly (HP:0000253)1.84274266
140Steatorrhea (HP:0002570)1.84245859
141Abdominal distention (HP:0003270)1.83488925
142Increased IgM level (HP:0003496)1.82678770
143Menorrhagia (HP:0000132)1.82528730
144Hepatosplenomegaly (HP:0001433)1.82196639
145Gastrointestinal inflammation (HP:0004386)1.82005107
146Obstructive lung disease (HP:0006536)1.81972163
147Chronic obstructive pulmonary disease (HP:0006510)1.81972163
148B lymphocytopenia (HP:0010976)1.81564461
149Abnormality of B cell number (HP:0010975)1.81564461
150Conjugated hyperbilirubinemia (HP:0002908)1.81478086
151Cholelithiasis (HP:0001081)1.81399499
152Redundant skin (HP:0001582)1.79821018
153Cellulitis (HP:0100658)1.78436960
154Abnormal number of erythroid precursors (HP:0012131)1.78180483
155Pustule (HP:0200039)1.76986697
156Multiple enchondromatosis (HP:0005701)1.76946073
157Macrocytic anemia (HP:0001972)1.76860827
158Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76287521
159Elevated alkaline phosphatase (HP:0003155)1.76194527
160Prominent metopic ridge (HP:0005487)1.76167892
161Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76019396
162Abnormal large intestine physiology (HP:0012700)1.74870243
163Prolonged neonatal jaundice (HP:0006579)1.73880172
164Recurrent fungal infections (HP:0002841)1.73869089
165Myositis (HP:0100614)1.73760940
166Gout (HP:0001997)1.73535102
167Impaired platelet aggregation (HP:0003540)1.73407600
168Abnormal platelet function (HP:0011869)1.73407600
169Ileus (HP:0002595)1.73066192
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.72875457
171Gingivitis (HP:0000230)1.71700820
172Type I diabetes mellitus (HP:0100651)1.71337025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.40604495
2EIF2AK33.82808485
3PASK3.57722224
4VRK23.25739854
5BCKDK3.11024218
6TAOK32.89978780
7INSRR2.76664301
8FLT32.70821005
9SCYL22.64145406
10IRAK32.45027513
11NME22.31972157
12IRAK42.28840771
13MAP4K12.01403652
14SMG11.95520971
15NME11.95065457
16TESK21.68205547
17MAPK151.60207528
18TYK21.59420691
19HIPK21.58629781
20JAK31.58534433
21PIM21.58417777
22STK161.57528719
23ZAP701.56114922
24TBK11.55225236
25TESK11.55054638
26CLK11.40548516
27PBK1.40509266
28TEC1.37388418
29PDK21.36639089
30BTK1.36620768
31LIMK11.34028742
32BLK1.32400915
33TRIB31.21592137
34MAP3K141.19355270
35TAOK21.17936340
36BRSK21.17664422
37PKN21.13391356
38EIF2AK11.12920111
39AURKA1.11091528
40KDR1.08139063
41SRPK11.05796404
42RPS6KA41.04108842
43FRK1.04089807
44NEK11.02574622
45EEF2K1.01815234
46KIT1.01641758
47MAP2K20.99792155
48VRK10.95945280
49SYK0.95776835
50ILK0.95497213
51MAPKAPK30.95250816
52EPHA20.95061003
53IKBKE0.92623568
54PAK10.89192903
55BRAF0.87340630
56WEE10.86332637
57BUB10.84140297
58MAP3K100.83427010
59CAMKK20.81463422
60ITK0.80640634
61RAF10.79732220
62LYN0.78434824
63CHEK20.78197492
64PIM10.77697645
65MAP3K120.77429905
66TTK0.76936026
67MAP3K10.76342364
68DYRK30.76308979
69ACVR1B0.76125010
70RPS6KA50.76045949
71JAK20.74354800
72STK40.73779633
73CSK0.73763611
74DAPK10.73254822
75CSF1R0.71707548
76IKBKB0.71437675
77JAK10.71241972
78NEK20.70077099
79DYRK1B0.69602172
80PIK3CG0.68385589
81DAPK30.68141213
82MAP3K110.68050625
83IRAK10.65451215
84LRRK20.64986782
85MAP3K20.64512424
86SIK10.64347730
87MAP2K30.63021984
88NLK0.62173798
89CCNB10.59203229
90CHUK0.58331833
91MAP3K30.56631585
92RPS6KB20.56574421
93ICK0.56015199
94IRAK20.55586190
95MAP3K80.55044957
96ARAF0.54104104
97PTK60.53488115
98STK100.52920882
99EPHA30.52896802
100CSNK1G30.52311685
101ZAK0.51671399
102CDC70.51594813
103EIF2AK20.51063954
104ATR0.46810590
105LCK0.46749886
106TLK10.46442756
107GRK60.45332362
108ABL20.43440008
109MAP2K60.43118743
110CSNK2A10.42879043
111TSSK60.42357106
112CSNK2A20.42025015
113PLK10.41671103
114PAK40.40545924
115RIPK40.40401091
116PRKG20.39298935
117BRSK10.39268177
118WNK40.38839159
119CDK80.38731224
120GRK70.38503634
121CDK70.38093613
122MST40.37840653
123CAMK2G0.37458624
124NEK90.37111765
125TXK0.36979703
126MAPKAPK50.36147990
127CHEK10.35897595
128MAPKAPK20.34917450
129MAPK110.34342850
130MST1R0.33918979
131PRKCI0.33798346
132AURKB0.31950595
133PLK40.31924830
134PRKCD0.31791737
135CSNK1A1L0.31774105
136MATK0.31633711
137CDK40.31022287
138RPS6KA60.30278989
139AKT20.28035382

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.77758307
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.19212804
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.14036574
4Oxidative phosphorylation_Homo sapiens_hsa001903.22918136
5N-Glycan biosynthesis_Homo sapiens_hsa005102.88738125
6Parkinsons disease_Homo sapiens_hsa050122.78276762
7Other glycan degradation_Homo sapiens_hsa005112.48712656
8Folate biosynthesis_Homo sapiens_hsa007902.29524149
9Sulfur metabolism_Homo sapiens_hsa009202.16432634
10Selenocompound metabolism_Homo sapiens_hsa004502.15976523
11DNA replication_Homo sapiens_hsa030302.10839569
12Antigen processing and presentation_Homo sapiens_hsa046122.03496111
13Huntingtons disease_Homo sapiens_hsa050161.91449307
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.86117465
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.78920100
16Alzheimers disease_Homo sapiens_hsa050101.77113081
17Lysosome_Homo sapiens_hsa041421.75789649
18Legionellosis_Homo sapiens_hsa051341.62946013
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62197353
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58513395
21One carbon pool by folate_Homo sapiens_hsa006701.41202091
22Ribosome_Homo sapiens_hsa030101.37320373
23Vibrio cholerae infection_Homo sapiens_hsa051101.36542268
24Proteasome_Homo sapiens_hsa030501.29368637
25Mismatch repair_Homo sapiens_hsa034301.28396182
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26712964
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25415773
28Glutathione metabolism_Homo sapiens_hsa004801.24892645
29Pancreatic secretion_Homo sapiens_hsa049721.24562077
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21464608
31Renin-angiotensin system_Homo sapiens_hsa046141.20973424
32Fat digestion and absorption_Homo sapiens_hsa049751.19302660
33Base excision repair_Homo sapiens_hsa034101.17558288
34Galactose metabolism_Homo sapiens_hsa000521.12740572
35Pyrimidine metabolism_Homo sapiens_hsa002401.10881740
36Carbon metabolism_Homo sapiens_hsa012001.09786625
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08763082
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06860201
39Sulfur relay system_Homo sapiens_hsa041221.06133375
40Type I diabetes mellitus_Homo sapiens_hsa049401.05344223
41Leishmaniasis_Homo sapiens_hsa051401.04357877
42Fatty acid elongation_Homo sapiens_hsa000621.01895307
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97118931
44Fanconi anemia pathway_Homo sapiens_hsa034600.95864192
45Phenylalanine metabolism_Homo sapiens_hsa003600.94499139
46Tyrosine metabolism_Homo sapiens_hsa003500.88109005
47Shigellosis_Homo sapiens_hsa051310.85368162
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.84594724
49Staphylococcus aureus infection_Homo sapiens_hsa051500.83595983
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80999242
51Homologous recombination_Homo sapiens_hsa034400.79439831
52Rheumatoid arthritis_Homo sapiens_hsa053230.78673408
53Allograft rejection_Homo sapiens_hsa053300.78262785
54Pentose phosphate pathway_Homo sapiens_hsa000300.77195309
55Autoimmune thyroid disease_Homo sapiens_hsa053200.75221878
56Pertussis_Homo sapiens_hsa051330.72505083
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.70366201
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69996309
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.68501918
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67661879
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66792485
62Fructose and mannose metabolism_Homo sapiens_hsa000510.66514763
63Vitamin B6 metabolism_Homo sapiens_hsa007500.66188042
64Pyruvate metabolism_Homo sapiens_hsa006200.65945660
65Tryptophan metabolism_Homo sapiens_hsa003800.65266014
66Measles_Homo sapiens_hsa051620.64423332
67Influenza A_Homo sapiens_hsa051640.64299480
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64232965
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63492879
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62947858
71Regulation of autophagy_Homo sapiens_hsa041400.61790859
72Nucleotide excision repair_Homo sapiens_hsa034200.61257657
73Herpes simplex infection_Homo sapiens_hsa051680.60592017
74Starch and sucrose metabolism_Homo sapiens_hsa005000.60192850
75Prion diseases_Homo sapiens_hsa050200.59952384
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59825302
77Cell cycle_Homo sapiens_hsa041100.59770950
78Primary immunodeficiency_Homo sapiens_hsa053400.59342708
79RNA polymerase_Homo sapiens_hsa030200.58246419
80Salmonella infection_Homo sapiens_hsa051320.58169172
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57704285
82Apoptosis_Homo sapiens_hsa042100.57684428
83Cardiac muscle contraction_Homo sapiens_hsa042600.57068246
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56897084
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56773106
86Phagosome_Homo sapiens_hsa041450.54360988
87Spliceosome_Homo sapiens_hsa030400.53855017
88Protein digestion and absorption_Homo sapiens_hsa049740.52987208
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52052863
90Histidine metabolism_Homo sapiens_hsa003400.51919482
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51044153
92Peroxisome_Homo sapiens_hsa041460.49345766
93Asthma_Homo sapiens_hsa053100.48977666
94Thyroid hormone synthesis_Homo sapiens_hsa049180.48340409
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48160914
96Collecting duct acid secretion_Homo sapiens_hsa049660.47147297
97Bladder cancer_Homo sapiens_hsa052190.47052999
98Biosynthesis of amino acids_Homo sapiens_hsa012300.46599595
99Systemic lupus erythematosus_Homo sapiens_hsa053220.46537601
100Osteoclast differentiation_Homo sapiens_hsa043800.45071295
101Tuberculosis_Homo sapiens_hsa051520.44930688
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.42297008
103Hematopoietic cell lineage_Homo sapiens_hsa046400.41408834
104Non-homologous end-joining_Homo sapiens_hsa034500.40906850
105p53 signaling pathway_Homo sapiens_hsa041150.40344779
106RNA transport_Homo sapiens_hsa030130.39633233
107Arginine and proline metabolism_Homo sapiens_hsa003300.39473771
108ABC transporters_Homo sapiens_hsa020100.38856455
109Epstein-Barr virus infection_Homo sapiens_hsa051690.38392501
110Linoleic acid metabolism_Homo sapiens_hsa005910.37961113
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37634561
112Arginine biosynthesis_Homo sapiens_hsa002200.37107816
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.36997356
114Caffeine metabolism_Homo sapiens_hsa002320.36250578
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35041014
116B cell receptor signaling pathway_Homo sapiens_hsa046620.35012470
117Toxoplasmosis_Homo sapiens_hsa051450.34449189
118Metabolic pathways_Homo sapiens_hsa011000.34214881
119Viral carcinogenesis_Homo sapiens_hsa052030.33855303
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.32754611
121Hepatitis B_Homo sapiens_hsa051610.31570630
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31170053
123Thyroid cancer_Homo sapiens_hsa052160.30416373
124Insulin resistance_Homo sapiens_hsa049310.29686341
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.29358872
126RNA degradation_Homo sapiens_hsa030180.28698617
127Purine metabolism_Homo sapiens_hsa002300.28452923
128Steroid biosynthesis_Homo sapiens_hsa001000.28434068
129Graft-versus-host disease_Homo sapiens_hsa053320.28154284
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27602884
131Acute myeloid leukemia_Homo sapiens_hsa052210.27597642
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27149560

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