SDF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.45471984
2COPI coating of Golgi vesicle (GO:0048205)6.45471984
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.39354025
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.39354025
5antigen processing and presentation of endogenous antigen (GO:0019883)4.68620313
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.49188155
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.35007144
8protein retention in ER lumen (GO:0006621)4.14157122
9barbed-end actin filament capping (GO:0051016)3.89611976
10signal peptide processing (GO:0006465)3.61278010
11skin morphogenesis (GO:0043589)3.51005990
12adhesion of symbiont to host (GO:0044406)3.50502252
13regulation of early endosome to late endosome transport (GO:2000641)3.41557580
14basement membrane organization (GO:0071711)3.33217584
15activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.21789155
16positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.17475530
17pinocytosis (GO:0006907)3.15931882
18stress fiber assembly (GO:0043149)3.15777258
19protein maturation by protein folding (GO:0022417)3.14666260
20peptide hormone processing (GO:0016486)3.04754851
21positive regulation of nuclease activity (GO:0032075)3.01155828
22vesicle coating (GO:0006901)2.97670676
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.94598564
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93547306
25response to laminar fluid shear stress (GO:0034616)2.92905807
26negative regulation of glycoprotein biosynthetic process (GO:0010561)2.91523653
27apoptotic cell clearance (GO:0043277)2.91357568
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.88540745
29endodermal cell differentiation (GO:0035987)2.86984106
30cell-substrate junction assembly (GO:0007044)2.86314176
31hyaluronan catabolic process (GO:0030214)2.84002814
32antigen processing and presentation via MHC class Ib (GO:0002475)2.82981276
33positive regulation of extracellular matrix organization (GO:1903055)2.82263839
34glycosphingolipid catabolic process (GO:0046479)2.79079499
35ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.79066527
36synaptic vesicle maturation (GO:0016188)2.77328468
37adherens junction assembly (GO:0034333)2.77027107
38COPII vesicle coating (GO:0048208)2.74822681
39endoplasmic reticulum unfolded protein response (GO:0030968)2.74611482
40regulation of amyloid precursor protein catabolic process (GO:1902991)2.72935926
41regulation of nuclease activity (GO:0032069)2.71617618
42positive regulation of Cdc42 GTPase activity (GO:0043089)2.71602912
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71535999
44regulation of beta-amyloid formation (GO:1902003)2.71393326
45cell adhesion mediated by integrin (GO:0033627)2.69477352
46hemidesmosome assembly (GO:0031581)2.68722925
47regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.68585020
48regulation of glucose import in response to insulin stimulus (GO:2001273)2.67746175
49low-density lipoprotein particle clearance (GO:0034383)2.67216256
50focal adhesion assembly (GO:0048041)2.66992851
51cell-substrate adherens junction assembly (GO:0007045)2.66992851
52regulation of synaptic vesicle exocytosis (GO:2000300)2.65947172
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.65527629
54mannose metabolic process (GO:0006013)2.64682585
55cellular response to unfolded protein (GO:0034620)2.64590471
56negative regulation of cell size (GO:0045792)2.64022010
57positive regulation of receptor recycling (GO:0001921)2.63342762
58vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.62637438
59epithelial cell-cell adhesion (GO:0090136)2.62033812
60negative regulation of fatty acid transport (GO:2000192)2.61487258
61positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.60896209
62proline biosynthetic process (GO:0006561)2.60779399
63protein heterotrimerization (GO:0070208)2.60391870
64peptidyl-proline hydroxylation (GO:0019511)2.59585645
65positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59061460
66positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58630814
67modulation by symbiont of host cellular process (GO:0044068)2.58314910
68regulation of cholesterol homeostasis (GO:2000188)2.56955191
69negative thymic T cell selection (GO:0045060)2.56784696
70negative T cell selection (GO:0043383)2.55610094
71glucose 6-phosphate metabolic process (GO:0051156)2.55477369
72ER-nucleus signaling pathway (GO:0006984)2.54874415
73positive regulation of vesicle fusion (GO:0031340)2.54869538
74activation of MAPKKK activity (GO:0000185)2.53784312
75positive regulation of gamma-delta T cell activation (GO:0046645)2.53710691
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51692058
77glycolipid catabolic process (GO:0019377)2.51526422
78regulation of membrane protein ectodomain proteolysis (GO:0051043)2.51366427
79activation of protein kinase A activity (GO:0034199)2.51357447
80cytoskeletal anchoring at plasma membrane (GO:0007016)2.51297417
81cellular response to topologically incorrect protein (GO:0035967)2.51232808
82semaphorin-plexin signaling pathway (GO:0071526)2.50212530
83embryo implantation (GO:0007566)2.50075090
84NIK/NF-kappaB signaling (GO:0038061)2.48328330
85apoptotic process involved in morphogenesis (GO:0060561)2.47590625
86pentose-phosphate shunt (GO:0006098)2.47438988
87regulation of extracellular matrix organization (GO:1903053)2.46705615
88glycine transport (GO:0015816)2.46453340
89planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42439205
90vascular endothelial growth factor signaling pathway (GO:0038084)2.42335612
91endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.42016948
92regulation of ARF protein signal transduction (GO:0032012)2.41189711
93endothelial cell chemotaxis (GO:0035767)2.41028841
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.38667120
95intra-Golgi vesicle-mediated transport (GO:0006891)2.38208699
96positive regulation of endothelial cell apoptotic process (GO:2000353)2.37709953
97epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36361033
98peptide catabolic process (GO:0043171)2.35006248
99regulation of isotype switching to IgG isotypes (GO:0048302)2.34883257
100sequestering of metal ion (GO:0051238)2.34200917
101negative regulation of glycoprotein metabolic process (GO:1903019)2.34039120
102response to endoplasmic reticulum stress (GO:0034976)2.33751335
103embryonic process involved in female pregnancy (GO:0060136)2.33582196
104collagen metabolic process (GO:0032963)2.33522835
105regulation of gamma-delta T cell differentiation (GO:0045586)2.31557272
106endocytic recycling (GO:0032456)2.31507825
107protein hydroxylation (GO:0018126)2.31080967
108peptidyl-tyrosine autophosphorylation (GO:0038083)2.30656944
109keratan sulfate catabolic process (GO:0042340)2.30335321
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.30143905
111regulation of apoptotic process involved in morphogenesis (GO:1902337)2.29487757
112glucose catabolic process (GO:0006007)2.29323352
113cellular potassium ion homeostasis (GO:0030007)2.28038354
114regulation of defense response to virus by virus (GO:0050690)2.27360154
115lipopolysaccharide-mediated signaling pathway (GO:0031663)2.27254514
116multicellular organismal macromolecule metabolic process (GO:0044259)2.27227638
117negative regulation of erythrocyte differentiation (GO:0045647)2.26897776
118fibril organization (GO:0097435)2.26135404
119extracellular matrix disassembly (GO:0022617)2.25946069
120activation of Rac GTPase activity (GO:0032863)2.25682680
121positive regulation of insulin secretion (GO:0032024)2.25524637
122collagen catabolic process (GO:0030574)2.24964795
123regulation of synaptic vesicle transport (GO:1902803)2.24324185
124NADH metabolic process (GO:0006734)2.24093533
125decidualization (GO:0046697)2.23811406
126nerve growth factor signaling pathway (GO:0038180)2.23792017
127succinate metabolic process (GO:0006105)2.23720523
128cortical actin cytoskeleton organization (GO:0030866)2.23589738
129toxin metabolic process (GO:0009404)2.23147825
130maternal placenta development (GO:0001893)2.22784299
131hypotonic response (GO:0006971)2.22714052
132glial cell migration (GO:0008347)2.21946477
133membrane protein ectodomain proteolysis (GO:0006509)2.21869904
134regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.21757720
135dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.21359577
136angiotensin maturation (GO:0002003)2.21341170
137neuromuscular process controlling posture (GO:0050884)2.20927087
138branching involved in mammary gland duct morphogenesis (GO:0060444)2.20905198
139cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.19949355
140response to thyroid hormone (GO:0097066)2.19282585
141cellular response to glucagon stimulus (GO:0071377)2.18861176
142cerebellar Purkinje cell layer development (GO:0021680)2.15652880
143ER overload response (GO:0006983)2.14710261
144valine metabolic process (GO:0006573)2.13259259
145glutamate secretion (GO:0014047)2.12164489
146potassium ion import (GO:0010107)2.11854692
147regulation of short-term neuronal synaptic plasticity (GO:0048172)2.10582207
148synaptic vesicle docking involved in exocytosis (GO:0016081)2.09454078
149positive regulation of catecholamine secretion (GO:0033605)2.09192700
150protein N-linked glycosylation via asparagine (GO:0018279)2.08840141
151ER to Golgi vesicle-mediated transport (GO:0006888)2.07648824
152response to unfolded protein (GO:0006986)2.07198939
153peptidyl-asparagine modification (GO:0018196)2.07007232
154response to interleukin-15 (GO:0070672)2.06911263
155exocrine pancreas development (GO:0031017)2.05938857
156regulation of T cell tolerance induction (GO:0002664)2.05791145
157regulation of autophagic vacuole assembly (GO:2000785)2.05527323
158positive regulation of peptide secretion (GO:0002793)2.04449506
159protein localization to endosome (GO:0036010)2.04063226
160adhesion of symbiont to host cell (GO:0044650)2.03759954
161virion attachment to host cell (GO:0019062)2.03759954
162positive thymic T cell selection (GO:0045059)2.03028734
163negative regulation of JUN kinase activity (GO:0043508)2.01545910
164oxaloacetate metabolic process (GO:0006107)2.01279405
165thymic T cell selection (GO:0045061)2.01054561
166regulation of insulin secretion (GO:0050796)2.00060416
167Golgi vesicle transport (GO:0048193)2.00052700
168sodium ion export (GO:0071436)2.00023906
169positive regulation of peptide hormone secretion (GO:0090277)1.99949274
170response to dietary excess (GO:0002021)1.99822059
171response to topologically incorrect protein (GO:0035966)1.99265181
172regulation of extracellular matrix disassembly (GO:0010715)1.99064459
173positive regulation of Rap GTPase activity (GO:0032854)1.98621842
174insulin secretion (GO:0030073)1.98543894
175locomotory exploration behavior (GO:0035641)1.97925840
176protein N-linked glycosylation (GO:0006487)1.94666651
177signal complex assembly (GO:0007172)1.93928155
178endocrine pancreas development (GO:0031018)1.92608380
179regulation of gamma-delta T cell activation (GO:0046643)1.91712106
180regulation of type B pancreatic cell apoptotic process (GO:2000674)1.91441640
181growth hormone receptor signaling pathway (GO:0060396)1.90277722

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.73790858
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.85769706
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82358314
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.56622267
5VDR_21846776_ChIP-Seq_THP-1_Human2.47759001
6GATA1_22025678_ChIP-Seq_K562_Human2.41624635
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25582688
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09113663
9ZNF263_19887448_ChIP-Seq_K562_Human2.08427948
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.07406308
11MYC_22102868_ChIP-Seq_BL_Human2.05670423
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95398362
13RUNX_20019798_ChIP-Seq_JUKART_Human1.89180481
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86470510
15RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.80405461
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.80022068
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79305857
18TCF7_22412390_ChIP-Seq_EML_Mouse1.78372385
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75013298
20CLOCK_20551151_ChIP-Seq_293T_Human1.74801667
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.72098774
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69734827
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67184269
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.66846131
25* KDM2B_26808549_Chip-Seq_K562_Human1.61393646
26DROSHA_22980978_ChIP-Seq_HELA_Human1.59166795
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.59122621
28* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59121728
29* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56935243
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56740083
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54830173
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54423190
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54099080
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53135254
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52587918
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52209178
37GATA1_19941826_ChIP-Seq_K562_Human1.51077018
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49393129
39* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48647482
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46580639
41* LXR_22292898_ChIP-Seq_THP-1_Human1.46090507
42SPI1_23127762_ChIP-Seq_K562_Human1.45330960
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.42947564
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41447943
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41305894
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.40429876
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40076692
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39655244
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38921599
50* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38886276
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36422179
52GATA3_27048872_Chip-Seq_THYMUS_Human1.36140739
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34577142
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34328905
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33824597
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33645516
57* SA1_27219007_Chip-Seq_ERYTHROID_Human1.33091500
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32827110
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32351882
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32213079
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31745533
62* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31572821
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31411114
64MYB_26560356_Chip-Seq_TH2_Human1.30719605
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30580571
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29673100
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28518518
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28323712
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28234375
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27834943
71* KDM2B_26808549_Chip-Seq_JURKAT_Human1.26809882
72ATF3_27146783_Chip-Seq_COLON_Human1.26690302
73TP53_22127205_ChIP-Seq_IMR90_Human1.25721548
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24819043
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24703943
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.24199342
77* P68_20966046_ChIP-Seq_HELA_Human1.24097097
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23987250
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22941871
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22268454
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21219389
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.21129770
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21114552
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19463938
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19317841
86IRF8_21731497_ChIP-ChIP_J774_Mouse1.17732201
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17601206
88* ERG_21242973_ChIP-ChIP_JURKAT_Human1.16826479
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16100576
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.15766836
91NCOR1_26117541_ChIP-Seq_K562_Human1.15022243
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14918380
93UBF1/2_26484160_Chip-Seq_HMECs_Human1.14646461
94* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13636722
95SOX2_20726797_ChIP-Seq_SW620_Human1.13507115
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12646021
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12620267
98* CREB1_26743006_Chip-Seq_LNCaP_Human1.12106136
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11111915
100* MAF_26560356_Chip-Seq_TH1_Human1.10691991
101SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10222389
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09341820
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08747456
104BP1_19119308_ChIP-ChIP_Hs578T_Human1.08107043
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08040524
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07417612
107* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07011442
108* MAF_26560356_Chip-Seq_TH2_Human1.06730258
109SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06566111
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06451282
111SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06010292
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05375835
113* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04049046
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02991218
115VDR_24763502_ChIP-Seq_THP-1_Human1.02425983
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02344603
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02339873
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02240428
119* ELF1_20517297_ChIP-Seq_JURKAT_Human1.01981091
120SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01344302
121GATA3_26560356_Chip-Seq_TH2_Human1.01228459
122P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01160805
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01006851
124* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99873149
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99223910
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98986878
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98986364
128BCOR_27268052_Chip-Seq_Bcells_Human0.97818757
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.97419117
130* KDM2B_26808549_Chip-Seq_DND41_Human0.96477642
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96432596
132MYB_26560356_Chip-Seq_TH1_Human0.95814001
133REST_18959480_ChIP-ChIP_MESCs_Mouse0.94930356
134SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94526496
135GATA2_19941826_ChIP-Seq_K562_Human0.93921732
136* UTX_26944678_Chip-Seq_JUKART_Human0.93893342
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.93652165
138* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93089504
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.92941379
140* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92312035
141SMC4_20622854_ChIP-Seq_HELA_Human0.92224734
142* ELK3_25401928_ChIP-Seq_HUVEC_Human0.89209108
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89040261
144NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88861332
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87888968
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87888968
147* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87597101
148NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86349267
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85792600
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.85572397
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84371842
152FOXH1_21741376_ChIP-Seq_ESCs_Human0.83699367
153SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82983685
154RACK7_27058665_Chip-Seq_MCF-7_Human0.82972686
155FOXA2_19822575_ChIP-Seq_HepG2_Human0.82343511
156TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81819152
157FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80907225
158AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80388669
159RUNX1_22412390_ChIP-Seq_EML_Mouse0.80216068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.18953284
2MP0000013_abnormal_adipose_tissue3.67538118
3MP0002909_abnormal_adrenal_gland3.00115278
4MP0003183_abnormal_peptide_metabolism2.82849049
5MP0005451_abnormal_body_composition2.79001017
6MP0003300_gastrointestinal_ulcer2.78434844
7MP0005058_abnormal_lysosome_morphology2.66087667
8MP0003566_abnormal_cell_adhesion2.43521536
9MP0004272_abnormal_basement_membrane2.33839448
10MP0003279_aneurysm2.32721562
11MP0004859_abnormal_synaptic_plasticity2.28077273
12MP0005257_abnormal_intraocular_pressure2.27169438
13MP0009780_abnormal_chondrocyte_physiolo2.16547326
14MP0002877_abnormal_melanocyte_morpholog2.13367321
15MP0001849_ear_inflammation1.94401599
16MP0010386_abnormal_urinary_bladder1.90192590
17MP0008438_abnormal_cutaneous_collagen1.88718207
18MP0003724_increased_susceptibility_to1.87020585
19MP0003091_abnormal_cell_migration1.86895956
20MP0003191_abnormal_cellular_cholesterol1.86316636
21MP0003172_abnormal_lysosome_physiology1.85798722
22MP0009840_abnormal_foam_cell1.83734534
23MP0008260_abnormal_autophagy1.83407408
24MP0004043_abnormal_pH_regulation1.82021532
25MP0005671_abnormal_response_to1.82020198
26MP0005310_abnormal_salivary_gland1.77017361
27MP0000003_abnormal_adipose_tissue1.77009590
28MP0002693_abnormal_pancreas_physiology1.76979641
29MP0000858_altered_metastatic_potential1.75140414
30MP0003195_calcinosis1.74150561
31MP0000604_amyloidosis1.74024070
32MP0003329_amyloid_beta_deposits1.73778115
33MP0003866_abnormal_defecation1.73456754
34MP0005379_endocrine/exocrine_gland_phen1.69999154
35MP0005076_abnormal_cell_differentiation1.69007173
36MP0002166_altered_tumor_susceptibility1.65275239
37MP0000685_abnormal_immune_system1.63392706
38MP0005275_abnormal_skin_tensile1.60975944
39MP0005023_abnormal_wound_healing1.59807246
40MP0003453_abnormal_keratinocyte_physiol1.57375041
41MP0001765_abnormal_ion_homeostasis1.57171264
42MP0001944_abnormal_pancreas_morphology1.54111334
43MP0005360_urolithiasis1.50781605
44MP0006082_CNS_inflammation1.50118625
45MP0003075_altered_response_to1.49714028
46MP0002822_catalepsy1.48278324
47MP0005365_abnormal_bile_salt1.47729126
48MP0001835_abnormal_antigen_presentation1.46930956
49MP0003045_fibrosis1.46861672
50MP0001756_abnormal_urination1.41609277
51MP0000920_abnormal_myelination1.39350984
52MP0003690_abnormal_glial_cell1.38208710
53MP0002060_abnormal_skin_morphology1.38182349
54MP0001790_abnormal_immune_system1.34945511
55MP0005387_immune_system_phenotype1.34945511
56MP0005503_abnormal_tendon_morphology1.34504714
57MP0001873_stomach_inflammation1.32504801
58MP0005623_abnormal_meninges_morphology1.31912991
59MP0001533_abnormal_skeleton_physiology1.31434723
60MP0000751_myopathy1.30237443
61MP0003436_decreased_susceptibility_to1.30011718
62MP0009643_abnormal_urine_homeostasis1.27267599
63MP0001666_abnormal_nutrient_absorption1.26170842
64MP0009278_abnormal_bone_marrow1.25153029
65MP0000678_abnormal_parathyroid_gland1.24618477
66MP0005000_abnormal_immune_tolerance1.24274565
67MP0003763_abnormal_thymus_physiology1.24161699
68MP0000767_abnormal_smooth_muscle1.23473356
69MP0001542_abnormal_bone_strength1.22204773
70MP0008961_abnormal_basal_metabolism1.22059599
71MP0000343_altered_response_to1.20027529
72MP0002078_abnormal_glucose_homeostasis1.19836622
73MP0002933_joint_inflammation1.19556394
74MP0005409_darkened_coat_color1.18257613
75MP0009384_cardiac_valve_regurgitation1.17956261
76MP0008569_lethality_at_weaning1.17306284
77MP0004185_abnormal_adipocyte_glucose1.16673904
78MP0003635_abnormal_synaptic_transmissio1.16291757
79MP0003448_altered_tumor_morphology1.14817088
80MP0005220_abnormal_exocrine_pancreas1.14629342
81MP0001501_abnormal_sleep_pattern1.13474185
82MP0003633_abnormal_nervous_system1.12737688
83MP0006054_spinal_hemorrhage1.10364198
84MP0010234_abnormal_vibrissa_follicle1.08937211
85MP0004510_myositis1.08479944
86MP0005390_skeleton_phenotype1.07497450
87MP0004947_skin_inflammation1.05214953
88MP0010352_gastrointestinal_tract_polyps1.04194755
89MP0004233_abnormal_muscle_weight1.04112014
90MP0005535_abnormal_body_temperature1.04069496
91MP0005645_abnormal_hypothalamus_physiol1.03444695
92MP0002089_abnormal_postnatal_growth/wei1.03307069
93MP0002064_seizures1.02705844
94MP0010368_abnormal_lymphatic_system1.02548796
95MP0009333_abnormal_splenocyte_physiolog1.01578723
96MP0005464_abnormal_platelet_physiology1.01518841
97MP0001845_abnormal_inflammatory_respons0.99417464
98MP0009785_altered_susceptibility_to0.99068054
99MP0003303_peritoneal_inflammation0.98628801
100MP0003959_abnormal_lean_body0.98604629
101MP0005375_adipose_tissue_phenotype0.98541376
102MP0005636_abnormal_mineral_homeostasis0.98382930
103MP0010329_abnormal_lipoprotein_level0.98223925
104MP0002837_dystrophic_cardiac_calcinosis0.97663379
105MP0004270_analgesia0.97399294
106MP0002118_abnormal_lipid_homeostasis0.96189901
107MP0001348_abnormal_lacrimal_gland0.95396408
108MP0002796_impaired_skin_barrier0.95210233
109MP0005508_abnormal_skeleton_morphology0.94873640
110MP0010155_abnormal_intestine_physiology0.94862740
111MP0002138_abnormal_hepatobiliary_system0.94702897
112MP0000733_abnormal_muscle_development0.94566908
113MP0005025_abnormal_response_to0.94423734
114MP0005083_abnormal_biliary_tract0.93955016
115MP0005165_increased_susceptibility_to0.93733615
116MP0002723_abnormal_immune_serum0.93690780
117MP0002006_tumorigenesis0.92992520
118MP0004130_abnormal_muscle_cell0.92942890
119MP0001958_emphysema0.92702451
120MP0005666_abnormal_adipose_tissue0.92351200
121MP0002998_abnormal_bone_remodeling0.91672829
122MP0001915_intracranial_hemorrhage0.91257916
123MP0002272_abnormal_nervous_system0.91240485
124MP0009745_abnormal_behavioral_response0.90955854
125MP0004858_abnormal_nervous_system0.90495321
126MP0002419_abnormal_innate_immunity0.90492567
127MP0005584_abnormal_enzyme/coenzyme_acti0.90320940
128MP0001970_abnormal_pain_threshold0.90307950
129MP0001243_abnormal_dermal_layer0.89303969
130MP0002148_abnormal_hypersensitivity_rea0.88209045
131MP0000747_muscle_weakness0.88114820
132MP0003879_abnormal_hair_cell0.87741136
133MP0008469_abnormal_protein_level0.87355208
134MP0000639_abnormal_adrenal_gland0.86603249
135MP0005166_decreased_susceptibility_to0.86527426
136MP0002420_abnormal_adaptive_immunity0.86177810
137MP0000230_abnormal_systemic_arterial0.86105389
138MP0005164_abnormal_response_to0.85596018
139MP0001968_abnormal_touch/_nociception0.85350171
140MP0005332_abnormal_amino_acid0.84308929
141MP0001819_abnormal_immune_cell0.84247117
142MP0003795_abnormal_bone_structure0.83637719
143MP0002139_abnormal_hepatobiliary_system0.81094748
144MP0000681_abnormal_thyroid_gland0.80539559
145MP0003828_pulmonary_edema0.80081920
146MP0005501_abnormal_skin_physiology0.80073674
147MP0005167_abnormal_blood-brain_barrier0.79693026
148MP0002896_abnormal_bone_mineralization0.79528469
149MP0001800_abnormal_humoral_immune0.79008931
150MP0000490_abnormal_crypts_of0.74567744
151MP0003634_abnormal_glial_cell0.74388773
152MP0002254_reproductive_system_inflammat0.73627814
153MP0001216_abnormal_epidermal_layer0.72843147
154MP0000249_abnormal_blood_vessel0.71244557
155MP0005621_abnormal_cell_physiology0.70377000
156MP0005595_abnormal_vascular_smooth0.69053059
157MP0001853_heart_inflammation0.68239970
158MP0000750_abnormal_muscle_regeneration0.68108603
159MP0000759_abnormal_skeletal_muscle0.67472925
160MP0009931_abnormal_skin_appearance0.65832580

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.87160319
2Protrusio acetabuli (HP:0003179)4.75963919
3Dysostosis multiplex (HP:0000943)4.18212007
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.95569181
5Vertebral compression fractures (HP:0002953)3.70499917
6Urinary glycosaminoglycan excretion (HP:0003541)3.46891695
7Mucopolysacchariduria (HP:0008155)3.46891695
8Vacuolated lymphocytes (HP:0001922)3.24314858
9Abnormality of polysaccharide metabolism (HP:0011012)3.07241925
10Abnormality of glycosaminoglycan metabolism (HP:0004371)3.07241925
11Abnormality of mucopolysaccharide metabolism (HP:0011020)3.07241925
12Hypoglycemic seizures (HP:0002173)3.06109069
13Hypoglycemic coma (HP:0001325)2.99976757
14Papilledema (HP:0001085)2.94139916
15Achilles tendon contracture (HP:0001771)2.81066472
16Atrophic scars (HP:0001075)2.78415889
17Increased cerebral lipofuscin (HP:0011813)2.74886853
18Chronic otitis media (HP:0000389)2.70765297
19Fragile skin (HP:0001030)2.68635348
20Supranuclear gaze palsy (HP:0000605)2.68234316
21Hyperinsulinemic hypoglycemia (HP:0000825)2.67018335
22Abnormality of the Achilles tendon (HP:0005109)2.61762065
23Increased connective tissue (HP:0009025)2.61418355
24Ankle contracture (HP:0006466)2.61049918
25Retinal atrophy (HP:0001105)2.60965507
26Neurofibrillary tangles (HP:0002185)2.57315366
27Growth hormone excess (HP:0000845)2.53138076
28Blue sclerae (HP:0000592)2.52827512
29Hyperacusis (HP:0010780)2.52452514
30Spinal rigidity (HP:0003306)2.48716230
31Wormian bones (HP:0002645)2.47692324
32Bladder diverticulum (HP:0000015)2.46792196
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44591262
34Pheochromocytoma (HP:0002666)2.44228124
35Thin bony cortex (HP:0002753)2.42806369
36Distal lower limb amyotrophy (HP:0008944)2.40271835
37Symptomatic seizures (HP:0011145)2.38891999
38Loss of speech (HP:0002371)2.38889255
39Abnormality of calcium-phosphate metabolism (HP:0100530)2.37148481
40Beaking of vertebral bodies (HP:0004568)2.37097426
41Deep venous thrombosis (HP:0002625)2.33536174
42Hypercortisolism (HP:0001578)2.33215816
43Increased variability in muscle fiber diameter (HP:0003557)2.33008707
44Neuroendocrine neoplasm (HP:0100634)2.32211256
45Ketoacidosis (HP:0001993)2.31600853
46Elevated erythrocyte sedimentation rate (HP:0003565)2.31279806
47Dilatation of the ascending aorta (HP:0005111)2.29584806
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.29405760
49Distal lower limb muscle weakness (HP:0009053)2.28934918
50Ulnar bowing (HP:0003031)2.28594368
51Increased CSF protein (HP:0002922)2.27409800
52Abnormality of glycolipid metabolism (HP:0010969)2.24883516
53Abnormality of liposaccharide metabolism (HP:0010968)2.24883516
54Abnormality of glycosphingolipid metabolism (HP:0004343)2.24883516
55Abnormality of complement system (HP:0005339)2.24364244
56Hemorrhage of the eye (HP:0011885)2.24260549
57Genu recurvatum (HP:0002816)2.23202264
58Abnormality of the nasal mucosa (HP:0000433)2.22593798
59Mildly elevated creatine phosphokinase (HP:0008180)2.21748794
60Abnormality of the intrinsic pathway (HP:0010989)2.21696525
61Recurrent bronchitis (HP:0002837)2.21659718
62Nuclear cataract (HP:0100018)2.21609877
63Abnormality of the pancreatic islet cells (HP:0006476)2.21463337
64Abnormality of endocrine pancreas physiology (HP:0012093)2.21463337
65Biconcave vertebral bodies (HP:0004586)2.20104622
66Flat acetabular roof (HP:0003180)2.19458942
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19084483
68Shallow orbits (HP:0000586)2.18649714
69Aneurysm (HP:0002617)2.17667254
70Progressive neurologic deterioration (HP:0002344)2.16355949
71Axonal loss (HP:0003447)2.16319277
72Broad face (HP:0000283)2.14444907
73Peritonitis (HP:0002586)2.13996330
74Agitation (HP:0000713)2.13256834
75Nasal polyposis (HP:0100582)2.13228548
76Systemic lupus erythematosus (HP:0002725)2.11287833
77Mitral regurgitation (HP:0001653)2.11174065
78Large for gestational age (HP:0001520)2.10970181
79Disproportionate tall stature (HP:0001519)2.09172075
80Abnormality of skeletal muscle fiber size (HP:0012084)2.08358574
81Abnormality of dentin (HP:0010299)2.08104854
82J-shaped sella turcica (HP:0002680)2.07197334
83Striae distensae (HP:0001065)2.06564114
84Menstrual irregularities (HP:0000858)2.06103287
85Visual hallucinations (HP:0002367)2.03789905
86Abnormality of the common coagulation pathway (HP:0010990)2.03204622
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.00833026
88Osteolytic defects of the hand bones (HP:0009699)2.00833026
89Oligomenorrhea (HP:0000876)2.00493609
90Abnormality of T cell number (HP:0011839)2.00194734
91Hyperparathyroidism (HP:0000843)2.00110002
92Elbow flexion contracture (HP:0002987)1.99392867
93Short nail (HP:0001799)1.99382466
94Cerebral hemorrhage (HP:0001342)1.98454163
95Type 1 muscle fiber predominance (HP:0003803)1.97569876
96T lymphocytopenia (HP:0005403)1.97365448
97Hand muscle atrophy (HP:0009130)1.96922328
98Cerebral aneurysm (HP:0004944)1.95249570
99Action tremor (HP:0002345)1.94218154
100Hyperglycemia (HP:0003074)1.93708579
101Centrally nucleated skeletal muscle fibers (HP:0003687)1.93206574
102Interstitial pulmonary disease (HP:0006530)1.91716176
103Aortic aneurysm (HP:0004942)1.89853558
104Intention tremor (HP:0002080)1.88796883
105Myocardial infarction (HP:0001658)1.88770470
106Abnormality of the acetabulum (HP:0003170)1.88387757
107Cerebral inclusion bodies (HP:0100314)1.88346723
108Asymmetric septal hypertrophy (HP:0001670)1.88161285
109Decreased circulating renin level (HP:0003351)1.87656751
110Eczematoid dermatitis (HP:0000976)1.87587153
111Myokymia (HP:0002411)1.86520151
112Spondylolisthesis (HP:0003302)1.85518107
113Arterial tortuosity (HP:0005116)1.85463145
114Generalized amyotrophy (HP:0003700)1.84979239
115Protuberant abdomen (HP:0001538)1.84585580
116Cervical subluxation (HP:0003308)1.83013118
117Complement deficiency (HP:0004431)1.82671320
118Cardiomegaly (HP:0001640)1.82539763
119Soft skin (HP:0000977)1.82493865
120Ovoid vertebral bodies (HP:0003300)1.82318234
121Neonatal short-limb short stature (HP:0008921)1.82258049
122Slender build (HP:0001533)1.81617383
123Insulin-resistant diabetes mellitus (HP:0000831)1.81209170
124Upper limb amyotrophy (HP:0009129)1.81079333
125Distal upper limb amyotrophy (HP:0007149)1.81079333
126Macroorchidism (HP:0000053)1.80734160
127Fatigue (HP:0012378)1.80165656
128Amyloidosis (HP:0011034)1.80148574
129Pancreatic islet-cell hyperplasia (HP:0004510)1.79667142
130Joint stiffness (HP:0001387)1.78140146
131Abnormality of macrophages (HP:0004311)1.77891352
132Joint laxity (HP:0001388)1.77745380
133Mitral valve prolapse (HP:0001634)1.77546414
134Hyperextensible skin (HP:0000974)1.76993467
135Abnormality of carpal bone ossification (HP:0006257)1.76967122
136Vascular tortuosity (HP:0004948)1.76690636
137Obstructive sleep apnea (HP:0002870)1.76673427
138Mitral stenosis (HP:0001718)1.76514031
139Nonimmune hydrops fetalis (HP:0001790)1.75519149
140Type II lissencephaly (HP:0007260)1.75416029
141Increased circulating renin level (HP:0000848)1.75351361
142Bone pain (HP:0002653)1.75164792
143Emphysema (HP:0002097)1.74782384
144Hypokalemic alkalosis (HP:0001949)1.74591480
145Broad metatarsal (HP:0001783)1.74589460
146Ketosis (HP:0001946)1.74183982
147Abnormality of the distal phalanges of the toes (HP:0010182)1.74176033
148Anxiety (HP:0000739)1.73900330
149Coxa vara (HP:0002812)1.73035631
150Natal tooth (HP:0000695)1.72753218
151Depression (HP:0000716)1.72627976
152Atonic seizures (HP:0010819)1.72585862
153Severe short stature (HP:0003510)1.72414886
154Cupped ribs (HP:0000887)1.71971281
155Ankle clonus (HP:0011448)1.71549497
156Aortic dissection (HP:0002647)1.70123200
157Abnormal ossification of hand bones (HP:0005921)1.70100558
158Back pain (HP:0003418)1.69087062
159Adrenal overactivity (HP:0002717)1.69021777
160Stridor (HP:0010307)1.68490425
161Abnormality of renin-angiotensin system (HP:0000847)1.68150324
162Disproportionate short-trunk short stature (HP:0003521)1.68139885
163Thrombocytosis (HP:0001894)1.67904855
164Polycythemia (HP:0001901)1.67058502
165Autoimmune hemolytic anemia (HP:0001890)1.66612905
166Epiphyseal dysplasia (HP:0002656)1.63113516
167Late onset (HP:0003584)1.62708987
168Enlarged penis (HP:0000040)1.62498434
169Abnormal tarsal ossification (HP:0008369)1.60703675
170Sensorimotor neuropathy (HP:0007141)1.60160033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.19492696
2PRPF4B2.84403950
3ERN12.79087719
4TRIB32.64166861
5SMG12.54473167
6ICK2.36317634
7INSRR2.27578421
8CAMKK22.25964055
9NME22.11379909
10PRKD32.04677332
11ZAP702.01982852
12TTN1.98181693
13EPHA21.96549585
14NTRK11.95463043
15PIK3CG1.94666672
16FGFR41.94157019
17MAP3K21.93862128
18TXK1.93174724
19EPHB11.92309155
20MAPK151.92073518
21MAP4K11.89979653
22PRKCH1.86524164
23TAOK31.84986434
24JAK11.80440049
25EEF2K1.77266203
26JAK31.71127336
27WNK41.70496658
28TAOK21.69642404
29DDR21.66281498
30SCYL21.64567162
31ARAF1.60559759
32CAMKK11.60410461
33ITK1.56869092
34KSR21.52795922
35FRK1.52037133
36PAK41.51515338
37PIM21.47639252
38LMTK21.44640333
39CDK121.44191250
40MAP3K111.43281970
41MAP2K31.43055924
42MAP3K31.39558967
43TYK21.36790582
44NTRK31.35697837
45MAP3K131.35118485
46MST1R1.33913729
47MAP3K11.33506259
48CDC42BPA1.33220342
49HIPK21.30082574
50CDK191.28775642
51TBK11.21771905
52PRKD21.20560250
53BCKDK1.18174807
54JAK21.16406693
55PKN21.12498115
56FLT31.12313245
57RIPK11.11967430
58LATS21.07424835
59EPHB21.06996491
60UHMK11.06936569
61RET1.05674027
62EPHA31.05539558
63MOS1.04809296
64WNK31.04773007
65PTK61.04490806
66IKBKE1.03843938
67LRRK20.99795460
68SIK10.98920664
69DAPK20.98920460
70TGFBR20.97286894
71PDK10.95785145
72STK390.94110885
73TEC0.93199924
74MAP3K90.90273308
75MTOR0.88090044
76FES0.88085184
77WNK10.86380773
78RPS6KA20.85723359
79MAP3K120.84619929
80PDPK10.84252719
81MARK20.82423971
82KDR0.79143383
83PAK20.78006965
84ABL20.74442221
85PAK60.74422019
86PASK0.74034406
87TIE10.73946767
88SIK20.72904498
89PDGFRA0.72300124
90LCK0.71003931
91FGFR30.70954117
92TAOK10.70028779
93CDK50.69257746
94IRAK40.69013075
95MYLK0.68818722
96MAP3K100.68649938
97OXSR10.67805051
98SYK0.67710193
99BMX0.66068978
100KIT0.65408696
101MAP3K80.65155595
102LIMK10.64603588
103RPS6KC10.63393178
104RPS6KL10.63393178
105MAPK110.63302214
106MAPKAPK30.62442002
107CSK0.62306953
108MAP3K60.62262647
109RIPK40.60755939
110NEK90.60665711
111MET0.60242796
112PRKCQ0.60221792
113TESK10.60202622
114BTK0.59812779
115PRKG20.58540822
116PTK20.57535133
117TNK20.57096265
118FER0.57073779
119MAP2K20.56031339
120MINK10.55279854
121GRK60.54524725
122MAPKAPK50.54229477
123PAK30.54028426
124DAPK10.53752436
125TESK20.53348421
126GRK50.51703320
127SGK2230.51025294
128SGK4940.51025294
129PRKD10.49543589
130BRAF0.49122118
131IRAK20.49114378
132STK380.48748317
133DYRK1B0.48468395
134PDGFRB0.48321346
135MST40.47752256
136MAP2K10.47448604
137DAPK30.46447547
138TYRO30.45766250
139SGK30.45648723
140NLK0.45554850
141MAP3K140.45487922
142FYN0.45361228
143BLK0.45240443
144ILK0.45121337
145CDK60.44685261
146HCK0.41733894
147MAP3K70.41476544
148ALK0.40987076
149CAMK2G0.40763109
150ROCK20.40207224
151RPS6KA60.39109257
152CAMK10.38934998
153MAPKAPK20.38092367
154MATK0.36681829
155SIK30.36355332
156CSF1R0.33862205
157MAPK70.33336277
158MAPK120.31710109

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.00326163
2Protein export_Homo sapiens_hsa030602.77068291
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.72487041
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.03620263
5Lysosome_Homo sapiens_hsa041422.01417136
6Insulin secretion_Homo sapiens_hsa049112.00890242
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89378257
8Bladder cancer_Homo sapiens_hsa052191.78674001
9Nitrogen metabolism_Homo sapiens_hsa009101.77745781
10Vibrio cholerae infection_Homo sapiens_hsa051101.77468464
11Type I diabetes mellitus_Homo sapiens_hsa049401.77315892
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76108850
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.72990765
14Synaptic vesicle cycle_Homo sapiens_hsa047211.71315044
15Fructose and mannose metabolism_Homo sapiens_hsa000511.65326582
16Galactose metabolism_Homo sapiens_hsa000521.57426082
17Other glycan degradation_Homo sapiens_hsa005111.56769604
18Acute myeloid leukemia_Homo sapiens_hsa052211.54402258
19Chronic myeloid leukemia_Homo sapiens_hsa052201.54260275
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.53906687
21Sulfur metabolism_Homo sapiens_hsa009201.51578033
22Pancreatic secretion_Homo sapiens_hsa049721.49334060
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47293051
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45459004
25Amoebiasis_Homo sapiens_hsa051461.45105348
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.39962706
27Pentose phosphate pathway_Homo sapiens_hsa000301.37804329
28ECM-receptor interaction_Homo sapiens_hsa045121.35193526
29Focal adhesion_Homo sapiens_hsa045101.34093965
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32810958
31Type II diabetes mellitus_Homo sapiens_hsa049301.32260909
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26794905
33TNF signaling pathway_Homo sapiens_hsa046681.25174663
34Thyroid hormone synthesis_Homo sapiens_hsa049181.22958510
35Notch signaling pathway_Homo sapiens_hsa043301.22748632
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21268766
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20502332
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.20272382
39GABAergic synapse_Homo sapiens_hsa047271.19052248
40Salmonella infection_Homo sapiens_hsa051321.17964364
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16980487
42Pancreatic cancer_Homo sapiens_hsa052121.16898870
43N-Glycan biosynthesis_Homo sapiens_hsa005101.13120290
44Complement and coagulation cascades_Homo sapiens_hsa046101.12791390
45Malaria_Homo sapiens_hsa051441.12531809
46Gastric acid secretion_Homo sapiens_hsa049711.11911091
47Antigen processing and presentation_Homo sapiens_hsa046121.11294465
48Cocaine addiction_Homo sapiens_hsa050301.10087590
49T cell receptor signaling pathway_Homo sapiens_hsa046601.08118059
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08097810
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06721901
52Shigellosis_Homo sapiens_hsa051311.06371552
53Amphetamine addiction_Homo sapiens_hsa050311.05529394
54Circadian entrainment_Homo sapiens_hsa047131.04163716
55Proteoglycans in cancer_Homo sapiens_hsa052051.04006503
56Small cell lung cancer_Homo sapiens_hsa052221.03292660
57Hepatitis C_Homo sapiens_hsa051601.02996094
58Non-small cell lung cancer_Homo sapiens_hsa052231.02971112
59Long-term potentiation_Homo sapiens_hsa047201.01110840
60Apoptosis_Homo sapiens_hsa042100.95511419
61Renin-angiotensin system_Homo sapiens_hsa046140.93262618
62Primary immunodeficiency_Homo sapiens_hsa053400.92623599
63Dopaminergic synapse_Homo sapiens_hsa047280.92428205
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91495302
65Renin secretion_Homo sapiens_hsa049240.91004428
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.89840430
67Salivary secretion_Homo sapiens_hsa049700.89665392
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89409911
69Cholinergic synapse_Homo sapiens_hsa047250.88371075
70Olfactory transduction_Homo sapiens_hsa047400.85914172
71Protein digestion and absorption_Homo sapiens_hsa049740.84832196
72Biosynthesis of amino acids_Homo sapiens_hsa012300.84763800
73Renal cell carcinoma_Homo sapiens_hsa052110.84468184
74Allograft rejection_Homo sapiens_hsa053300.84363509
75Hepatitis B_Homo sapiens_hsa051610.83828068
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83786505
77Autoimmune thyroid disease_Homo sapiens_hsa053200.83761430
78Rheumatoid arthritis_Homo sapiens_hsa053230.83401887
79Endocytosis_Homo sapiens_hsa041440.83134837
80Morphine addiction_Homo sapiens_hsa050320.82667574
81Prion diseases_Homo sapiens_hsa050200.82432716
82Influenza A_Homo sapiens_hsa051640.82323455
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80348223
84Osteoclast differentiation_Homo sapiens_hsa043800.79943471
85ABC transporters_Homo sapiens_hsa020100.79441006
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79009808
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78724457
88Endometrial cancer_Homo sapiens_hsa052130.78089730
89Collecting duct acid secretion_Homo sapiens_hsa049660.77306335
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75925520
91Thyroid cancer_Homo sapiens_hsa052160.75737041
92Insulin signaling pathway_Homo sapiens_hsa049100.75662833
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74618445
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.73240967
95PPAR signaling pathway_Homo sapiens_hsa033200.72994765
96Estrogen signaling pathway_Homo sapiens_hsa049150.72665676
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.72585018
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71036372
99Regulation of autophagy_Homo sapiens_hsa041400.70225757
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.69402726
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69361387
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.69350013
103Prolactin signaling pathway_Homo sapiens_hsa049170.68062595
104Glioma_Homo sapiens_hsa052140.68001522
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66937603
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66183280
107Pertussis_Homo sapiens_hsa051330.66070283
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66038017
109Viral myocarditis_Homo sapiens_hsa054160.65102572
110mTOR signaling pathway_Homo sapiens_hsa041500.64796738
111Chemokine signaling pathway_Homo sapiens_hsa040620.64528932
112Phenylalanine metabolism_Homo sapiens_hsa003600.64444853
113Insulin resistance_Homo sapiens_hsa049310.63023885
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62585998
115Sulfur relay system_Homo sapiens_hsa041220.62553575
116Platelet activation_Homo sapiens_hsa046110.62549672
117HIF-1 signaling pathway_Homo sapiens_hsa040660.62346422
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62018090
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61845336
120cAMP signaling pathway_Homo sapiens_hsa040240.61724942
121Bile secretion_Homo sapiens_hsa049760.60289854
122Arginine biosynthesis_Homo sapiens_hsa002200.60068027
123Glutamatergic synapse_Homo sapiens_hsa047240.58808563
124Carbon metabolism_Homo sapiens_hsa012000.57357637
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57296138
126Staphylococcus aureus infection_Homo sapiens_hsa051500.57235495
127AMPK signaling pathway_Homo sapiens_hsa041520.56913618
128ErbB signaling pathway_Homo sapiens_hsa040120.56783763
129Phagosome_Homo sapiens_hsa041450.56272366
130HTLV-I infection_Homo sapiens_hsa051660.55311604
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.54333154
132Prostate cancer_Homo sapiens_hsa052150.53948087
133Fat digestion and absorption_Homo sapiens_hsa049750.51821709
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51182360
135Toxoplasmosis_Homo sapiens_hsa051450.50419026
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50208502
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50128756
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49752039
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49253766
140Taste transduction_Homo sapiens_hsa047420.48527827
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48410555
142MicroRNAs in cancer_Homo sapiens_hsa052060.48374037
143Adherens junction_Homo sapiens_hsa045200.47651705
144Leishmaniasis_Homo sapiens_hsa051400.47308565
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46745683
146Caffeine metabolism_Homo sapiens_hsa002320.44304355
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.44104675
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43847647
149Tuberculosis_Homo sapiens_hsa051520.43653647
150Legionellosis_Homo sapiens_hsa051340.43360853
151Glycerolipid metabolism_Homo sapiens_hsa005610.40882987
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.39972003
153Oxytocin signaling pathway_Homo sapiens_hsa049210.39822290
154Jak-STAT signaling pathway_Homo sapiens_hsa046300.39217922
155B cell receptor signaling pathway_Homo sapiens_hsa046620.38885923
156Fatty acid degradation_Homo sapiens_hsa000710.38429416
157GnRH signaling pathway_Homo sapiens_hsa049120.37150857
158Glucagon signaling pathway_Homo sapiens_hsa049220.36883446
159Sphingolipid metabolism_Homo sapiens_hsa006000.35505258
160VEGF signaling pathway_Homo sapiens_hsa043700.34787598
161Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34610501
162Measles_Homo sapiens_hsa051620.34537604
163Butanoate metabolism_Homo sapiens_hsa006500.34205486

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