SDHA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)6.38472377
2lysine metabolic process (GO:0006553)5.72192001
3lysine catabolic process (GO:0006554)5.72192001
4NADH metabolic process (GO:0006734)5.56713976
52-oxoglutarate metabolic process (GO:0006103)5.10161882
6regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.05907079
7oxaloacetate metabolic process (GO:0006107)5.00483108
8aspartate family amino acid catabolic process (GO:0009068)4.87207412
9carnitine shuttle (GO:0006853)4.77637255
10regulation of acyl-CoA biosynthetic process (GO:0050812)4.73595078
11* succinate metabolic process (GO:0006105)4.70097965
12actin-myosin filament sliding (GO:0033275)4.65273707
13muscle filament sliding (GO:0030049)4.65273707
14Golgi transport vesicle coating (GO:0048200)4.58372663
15COPI coating of Golgi vesicle (GO:0048205)4.58372663
16fatty acid transmembrane transport (GO:1902001)4.56859140
17fatty acid beta-oxidation (GO:0006635)4.49350260
18regulation of coenzyme metabolic process (GO:0051196)4.46012236
19regulation of cofactor metabolic process (GO:0051193)4.46012236
20tricarboxylic acid metabolic process (GO:0072350)4.35025140
21cellular ketone body metabolic process (GO:0046950)4.17546833
22valine metabolic process (GO:0006573)4.16373033
23acetyl-CoA metabolic process (GO:0006084)4.12795936
24creatine metabolic process (GO:0006600)4.10146657
25short-chain fatty acid metabolic process (GO:0046459)4.09708599
26proline biosynthetic process (GO:0006561)4.09026880
27branched-chain amino acid catabolic process (GO:0009083)4.05441920
28regulation of relaxation of muscle (GO:1901077)4.03490608
29fatty acid oxidation (GO:0019395)4.01202835
30fatty acid catabolic process (GO:0009062)3.99383182
31lipid oxidation (GO:0034440)3.94094579
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.92242229
33L-phenylalanine catabolic process (GO:0006559)3.92242229
34urea cycle (GO:0000050)3.89732653
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.89682061
36L-phenylalanine metabolic process (GO:0006558)3.89682061
37branched-chain amino acid metabolic process (GO:0009081)3.89114327
38regulation of fatty acid oxidation (GO:0046320)3.86678389
39alpha-linolenic acid metabolic process (GO:0036109)3.86483218
40glyoxylate metabolic process (GO:0046487)3.83983469
41carnitine transport (GO:0015879)3.74831142
42amino-acid betaine transport (GO:0015838)3.74831142
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.74419974
44carnitine transmembrane transport (GO:1902603)3.74205554
45nitrogen cycle metabolic process (GO:0071941)3.73887554
46urea metabolic process (GO:0019627)3.72895443
47glycolytic process (GO:0006096)3.72372978
48biotin metabolic process (GO:0006768)3.67666027
49monocarboxylic acid catabolic process (GO:0072329)3.65318794
50amino-acid betaine metabolic process (GO:0006577)3.64624553
51ketone body metabolic process (GO:1902224)3.61531327
52regulation of sulfur metabolic process (GO:0042762)3.60910861
53dicarboxylic acid biosynthetic process (GO:0043650)3.60518929
54regulation of sequestering of triglyceride (GO:0010889)3.60077499
55carnitine metabolic process (GO:0009437)3.58396411
56actin-mediated cell contraction (GO:0070252)3.57921588
57regulation of actin filament-based movement (GO:1903115)3.56513780
58folic acid metabolic process (GO:0046655)3.52998978
59positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.47043230
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46123533
61positive regulation of fatty acid oxidation (GO:0046321)3.42258920
62fatty acid homeostasis (GO:0055089)3.39155142
63kynurenine metabolic process (GO:0070189)3.37807090
64retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.35300343
65sarcomere organization (GO:0045214)3.34061062
66positive regulation of fatty acid beta-oxidation (GO:0032000)3.33742934
67oxidative phosphorylation (GO:0006119)3.33440430
68negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.31651733
69dicarboxylic acid catabolic process (GO:0043649)3.30461331
70skeletal muscle contraction (GO:0003009)3.29076931
71aromatic amino acid family catabolic process (GO:0009074)3.27351256
72sarcoplasmic reticulum calcium ion transport (GO:0070296)3.27334763
73gluconeogenesis (GO:0006094)3.27189509
74glutamate metabolic process (GO:0006536)3.26574860
75cardiac myofibril assembly (GO:0055003)3.25824955
76regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.25063272
77regulation of fatty acid beta-oxidation (GO:0031998)3.23920757
78regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.23803645
79striated muscle contraction (GO:0006941)3.23514389
80quaternary ammonium group transport (GO:0015697)3.23046692
81regulation of triglyceride catabolic process (GO:0010896)3.22445599
82fructose metabolic process (GO:0006000)3.19893518
83mitochondrial fusion (GO:0008053)3.19185590
84negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.18414329
85triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.17249090
86acyl-CoA biosynthetic process (GO:0071616)3.13893315
87thioester biosynthetic process (GO:0035384)3.13893315
88cardiac muscle contraction (GO:0060048)3.13657426
89GDP-mannose metabolic process (GO:0019673)3.13013516
90ethanol oxidation (GO:0006069)3.12287183
91negative regulation of potassium ion transmembrane transport (GO:1901380)3.12106795
92alpha-amino acid catabolic process (GO:1901606)3.11977216
93proline metabolic process (GO:0006560)3.10834367
94cellular polysaccharide catabolic process (GO:0044247)3.10785420
95cysteine metabolic process (GO:0006534)3.10072532
96actin filament depolymerization (GO:0030042)3.08875951
97response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.08839188
98organic acid catabolic process (GO:0016054)3.08058273
99carboxylic acid catabolic process (GO:0046395)3.08058273
100cellular amino acid catabolic process (GO:0009063)3.08007056
101mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06941105
102protein maturation by protein folding (GO:0022417)3.04477169
103pyruvate metabolic process (GO:0006090)3.04084916
104sulfur amino acid catabolic process (GO:0000098)3.03956136
105regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.02191372
106regulation of translational fidelity (GO:0006450)3.00863524
107hexose biosynthetic process (GO:0019319)3.00835326
108maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98208928
109protein retention in ER lumen (GO:0006621)2.97093884
110* respiratory electron transport chain (GO:0022904)2.96232084
111thioester metabolic process (GO:0035383)2.95233214
112acyl-CoA metabolic process (GO:0006637)2.95233214
113galactose catabolic process (GO:0019388)2.94688460
114bile acid biosynthetic process (GO:0006699)2.93127266
115mitotic chromosome condensation (GO:0007076)2.90876216
116cell communication by electrical coupling (GO:0010644)2.90461349
117NAD metabolic process (GO:0019674)2.89113638
118* electron transport chain (GO:0022900)2.87790597
119citrulline biosynthetic process (GO:0019240)2.87694571
120mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87536958
121DNA unwinding involved in DNA replication (GO:0006268)2.86573554
122regulation of cell communication by electrical coupling (GO:0010649)2.86344337
123deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86300322
1244-hydroxyproline metabolic process (GO:0019471)2.83985200
125homocysteine metabolic process (GO:0050667)2.83926878
126regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.83671605
127DNA strand elongation involved in DNA replication (GO:0006271)2.83110207
128cell communication involved in cardiac conduction (GO:0086065)2.82349996
129nucleobase-containing small molecule interconversion (GO:0015949)2.81980994
130glutamine family amino acid biosynthetic process (GO:0009084)2.81654204
131tryptophan catabolic process (GO:0006569)2.81597035
132indole-containing compound catabolic process (GO:0042436)2.81597035
133indolalkylamine catabolic process (GO:0046218)2.81597035
134glycogen catabolic process (GO:0005980)2.81186753
135regulation of mitotic spindle organization (GO:0060236)2.80695923
136monosaccharide biosynthetic process (GO:0046364)2.79782626
137myofibril assembly (GO:0030239)2.78727453
138cellular modified amino acid catabolic process (GO:0042219)2.77850033
139coenzyme catabolic process (GO:0009109)2.77533649
140skeletal muscle adaptation (GO:0043501)2.76596924
141DNA strand elongation (GO:0022616)2.76123837
142regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.75693620
143polysaccharide catabolic process (GO:0000272)2.75564476
144pentose-phosphate shunt (GO:0006098)2.74899142
145glucan catabolic process (GO:0009251)2.74650672
146positive regulation of lipid catabolic process (GO:0050996)2.73741800
147regulation of fatty acid metabolic process (GO:0019217)2.73377440
148desmosome organization (GO:0002934)2.72282448
149nuclear pore complex assembly (GO:0051292)2.72033866
150actomyosin structure organization (GO:0031032)2.71343678
151nucleoside diphosphate biosynthetic process (GO:0009133)2.69628008
152citrulline metabolic process (GO:0000052)2.65867134
153regulation of mitochondrial translation (GO:0070129)2.65423993
154actin filament-based movement (GO:0030048)2.64169482
155cell-substrate adherens junction assembly (GO:0007045)2.63937094
156focal adhesion assembly (GO:0048041)2.63937094
157telomere maintenance via semi-conservative replication (GO:0032201)2.62047319
158regulation of cholesterol metabolic process (GO:0090181)2.59492744
159glucose 6-phosphate metabolic process (GO:0051156)2.59246369
160regulation of cholesterol biosynthetic process (GO:0045540)2.58810141
161regulation of skeletal muscle contraction (GO:0014819)2.55367613
162negative regulation of cell size (GO:0045792)2.54299384
163negative regulation of necroptotic process (GO:0060546)2.53291962
164bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51858823
165glucose metabolic process (GO:0006006)2.49630132
166* dicarboxylic acid metabolic process (GO:0043648)2.49561193
167response to muscle activity (GO:0014850)2.49306503
168positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.47660315
169quinone biosynthetic process (GO:1901663)2.47596888
170glucose catabolic process (GO:0006007)2.46805519
171regulation of the force of heart contraction (GO:0002026)2.46406766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.95782903
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.43440130
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.03252770
4E2F7_22180533_ChIP-Seq_HELA_Human4.58266773
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.43534602
6* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.13229648
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.00015318
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.97365629
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.46168716
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.17795594
11* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15356892
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.45593936
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.33784430
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30938332
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.23405014
16CLOCK_20551151_ChIP-Seq_293T_Human2.10428627
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09304120
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.04174538
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00594508
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93245306
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.91214188
22RACK7_27058665_Chip-Seq_MCF-7_Human1.82457049
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81221757
24GATA1_22025678_ChIP-Seq_K562_Human1.80952846
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.79629938
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.79489238
27* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75963493
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75259463
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.68753547
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.67631538
31EZH2_22144423_ChIP-Seq_EOC_Human1.67098999
32MYC_22102868_ChIP-Seq_BL_Human1.66113376
33XRN2_22483619_ChIP-Seq_HELA_Human1.65729656
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64960457
35VDR_21846776_ChIP-Seq_THP-1_Human1.64012412
36TBX20_22328084_ChIP-Seq_HEART_Mouse1.63844878
37TBX20_22080862_ChIP-Seq_HEART_Mouse1.63844878
38ZNF263_19887448_ChIP-Seq_K562_Human1.62030211
39* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60266709
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59870802
41* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59368767
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57782317
43* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57647980
44DCP1A_22483619_ChIP-Seq_HELA_Human1.56217513
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55703236
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55434543
47BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51770315
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.50260312
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.49565392
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.47765322
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46892104
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45789379
53DROSHA_22980978_ChIP-Seq_HELA_Human1.44455699
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.43355052
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41677161
56* RARB_27405468_Chip-Seq_BRAIN_Mouse1.41346046
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38819000
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37042227
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36722964
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36688134
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36354247
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34542263
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34285799
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33466869
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33050230
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32868476
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30014819
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29559613
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.28360715
70GBX2_23144817_ChIP-Seq_PC3_Human1.27954745
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27134978
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25743351
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25268947
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23254766
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22380667
76AR_21909140_ChIP-Seq_LNCAP_Human1.22176255
77* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21835515
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.21609623
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21276308
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21210877
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19463402
82* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.17414486
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17096790
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16859840
85ATF3_27146783_Chip-Seq_COLON_Human1.16126831
86* KDM5A_27292631_Chip-Seq_BREAST_Human1.15646761
87GABP_19822575_ChIP-Seq_HepG2_Human1.14810595
88* SRF_21415370_ChIP-Seq_HL-1_Mouse1.13819949
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13653719
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13211216
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11000113
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10578192
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09785988
94NCOR1_26117541_ChIP-Seq_K562_Human1.09564506
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08605127
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08425984
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06173648
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05931357
99HTT_18923047_ChIP-ChIP_STHdh_Human1.05600838
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05276868
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04596605
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04389511
103HNF4A_19822575_ChIP-Seq_HepG2_Human1.03863972
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03639180
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03607864
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03223045
107CIITA_25753668_ChIP-Seq_RAJI_Human1.03095011
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02968097
109YY1_21170310_ChIP-Seq_MESCs_Mouse1.02295216
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.02256450
111NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00671429
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99884161
113MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99558487
114TFEB_21752829_ChIP-Seq_HELA_Human0.98249473
115BCOR_27268052_Chip-Seq_Bcells_Human0.98178783
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97566947
117ELF1_20517297_ChIP-Seq_JURKAT_Human0.97210439
118SA1_27219007_Chip-Seq_ERYTHROID_Human0.96652761
119SOX2_21211035_ChIP-Seq_LN229_Gbm0.96538045
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95088995
121REST_21632747_ChIP-Seq_MESCs_Mouse0.93990514
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93775673
123* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91681818
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91259802
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90604314
126LXR_22292898_ChIP-Seq_THP-1_Human0.89555703
127BCAT_22108803_ChIP-Seq_LS180_Human0.89422645
128TAF15_26573619_Chip-Seq_HEK293_Human0.87621813
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.87347023
130SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85607598
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85071863
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82995854
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82195164
134EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80031047
135RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80031047
136GATA4_21415370_ChIP-Seq_HL-1_Mouse0.79735200
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78865677
138CTCF_27219007_Chip-Seq_Bcells_Human0.78595589
139ZNF274_21170338_ChIP-Seq_K562_Hela0.74428908
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.73985615
141SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73839392
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73393523
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73383392
144FOXH1_21741376_ChIP-Seq_ESCs_Human0.72816157
145CBP_21632823_ChIP-Seq_H3396_Human0.71840018
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71649670
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.71495329
148SMAD4_21799915_ChIP-Seq_A2780_Human0.71060750
149GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70984655
150TAF2_19829295_ChIP-Seq_ESCs_Human0.70866661
151GATA1_19941826_ChIP-Seq_K562_Human0.69938861
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.68826283
153CBP_20019798_ChIP-Seq_JUKART_Human0.68826283
154MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.68461146
155SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.67726182
156P68_20966046_ChIP-Seq_HELA_Human0.67425801
157CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.66332389
158GATA1_19941827_ChIP-Seq_MEL_Mouse0.66140820
159SOX2_27498859_Chip-Seq_STOMACH_Mouse0.66121301
160ZFP281_18757296_ChIP-ChIP_E14_Mouse0.65467741
161SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.65243481
162KLF4_19829295_ChIP-Seq_ESCs_Human0.64685553
163AR_19668381_ChIP-Seq_PC3_Human0.64627765
164OCT4_20526341_ChIP-Seq_ESCs_Human0.63770299
165* SMC4_20622854_ChIP-Seq_HELA_Human0.63043287
166NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62932771
167NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62932771
168SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62457739
169PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.61760397
170ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61744493
171GATA2_19941826_ChIP-Seq_K562_Human0.60971690
172GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.60364797
173* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.60354156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.73728893
2MP0005360_urolithiasis4.13177284
3MP0002139_abnormal_hepatobiliary_system4.04187726
4MP0003646_muscle_fatigue3.88664879
5MP0005085_abnormal_gallbladder_physiolo3.24902162
6MP0000751_myopathy3.19962130
7MP0005451_abnormal_body_composition3.16384407
8MP0004084_abnormal_cardiac_muscle3.15719614
9MP0005365_abnormal_bile_salt3.10195843
10MP0004130_abnormal_muscle_cell2.94051012
11MP0004215_abnormal_myocardial_fiber2.91866869
12MP0004036_abnormal_muscle_relaxation2.78710370
13MP0008875_abnormal_xenobiotic_pharmacok2.76257566
14MP0002877_abnormal_melanocyte_morpholog2.50333740
15MP0003806_abnormal_nucleotide_metabolis2.48887363
16MP0006036_abnormal_mitochondrial_physio2.47685326
17MP0001661_extended_life_span2.47383443
18MP0005330_cardiomyopathy2.33978970
19MP0010329_abnormal_lipoprotein_level2.30757771
20MP0000749_muscle_degeneration2.27742972
21MP0005332_abnormal_amino_acid2.23016616
22MP0010234_abnormal_vibrissa_follicle2.22296063
23MP0004043_abnormal_pH_regulation2.08430977
24MP0005670_abnormal_white_adipose2.05086970
25MP0005058_abnormal_lysosome_morphology2.02087027
26MP0003195_calcinosis1.95592650
27MP0003252_abnormal_bile_duct1.93198599
28MP0002822_catalepsy1.87723648
29MP0008775_abnormal_heart_ventricle1.85414193
30MP0004087_abnormal_muscle_fiber1.82816106
31MP0002972_abnormal_cardiac_muscle1.81348900
32MP0005620_abnormal_muscle_contractility1.78690819
33MP0005666_abnormal_adipose_tissue1.73240833
34MP0002269_muscular_atrophy1.72617490
35MP0003111_abnormal_nucleus_morphology1.67668001
36MP0006035_abnormal_mitochondrial_morpho1.67252016
37MP0002118_abnormal_lipid_homeostasis1.62946152
38MP0003693_abnormal_embryo_hatching1.61846687
39MP0010094_abnormal_chromosome_stability1.60808072
40MP0000747_muscle_weakness1.60710667
41MP0005584_abnormal_enzyme/coenzyme_acti1.57176339
42MP0003137_abnormal_impulse_conducting1.53474640
43MP0004484_altered_response_of1.51792664
44MP0005408_hypopigmentation1.51767488
45MP0001544_abnormal_cardiovascular_syste1.50433962
46MP0005385_cardiovascular_system_phenoty1.50433962
47MP0006138_congestive_heart_failure1.50140261
48MP0004145_abnormal_muscle_electrophysio1.47942330
49MP0004859_abnormal_synaptic_plasticity1.45259830
50MP0005535_abnormal_body_temperature1.44821980
51MP0000013_abnormal_adipose_tissue1.44737663
52MP0004233_abnormal_muscle_weight1.43989612
53MP0009840_abnormal_foam_cell1.41489670
54MP0009697_abnormal_copulation1.40541031
55MP0005319_abnormal_enzyme/_coenzyme1.40473579
56MP0004085_abnormal_heartbeat1.37458560
57MP0002971_abnormal_brown_adipose1.37242383
58MP0001666_abnormal_nutrient_absorption1.37115029
59MP0002909_abnormal_adrenal_gland1.36539931
60MP0002106_abnormal_muscle_physiology1.36492149
61MP0008260_abnormal_autophagy1.34558193
62MP0003221_abnormal_cardiomyocyte_apopto1.33371949
63MP0009780_abnormal_chondrocyte_physiolo1.27558910
64MP0005083_abnormal_biliary_tract1.27093358
65MP0004957_abnormal_blastocyst_morpholog1.26925730
66MP0003950_abnormal_plasma_membrane1.26217948
67MP0010630_abnormal_cardiac_muscle1.24115185
68MP0002078_abnormal_glucose_homeostasis1.22870122
69MP0003191_abnormal_cellular_cholesterol1.21718349
70MP0003329_amyloid_beta_deposits1.17525245
71MP0003077_abnormal_cell_cycle1.16694805
72MP0005375_adipose_tissue_phenotype1.15367473
73MP0008007_abnormal_cellular_replicative1.14805625
74MP0000609_abnormal_liver_physiology1.14603885
75MP0000678_abnormal_parathyroid_gland1.14436371
76MP0000759_abnormal_skeletal_muscle1.13334581
77MP0005076_abnormal_cell_differentiation1.12534333
78MP0008932_abnormal_embryonic_tissue1.12426719
79MP0002332_abnormal_exercise_endurance1.11714696
80MP0005369_muscle_phenotype1.11245637
81MP0000750_abnormal_muscle_regeneration1.11052031
82MP0009643_abnormal_urine_homeostasis1.09030686
83MP0000733_abnormal_muscle_development1.08896257
84MP0004185_abnormal_adipocyte_glucose1.07438895
85MP0005266_abnormal_metabolism1.07336413
86MP0000230_abnormal_systemic_arterial1.04778129
87MP0004147_increased_porphyrin_level1.02753259
88MP0003635_abnormal_synaptic_transmissio1.00280728
89MP0001730_embryonic_growth_arrest0.98684917
90MP0003566_abnormal_cell_adhesion0.98411609
91MP0008961_abnormal_basal_metabolism0.97665939
92MP0000358_abnormal_cell_content/0.94575716
93MP0009745_abnormal_behavioral_response0.93867598
94MP0010352_gastrointestinal_tract_polyps0.92638818
95MP0004264_abnormal_extraembryonic_tissu0.92220330
96MP0002064_seizures0.90990546
97MP0009046_muscle_twitch0.90227533
98MP0004019_abnormal_vitamin_homeostasis0.90066156
99MP0001764_abnormal_homeostasis0.88523413
100MP0000003_abnormal_adipose_tissue0.85684484
101MP0005448_abnormal_energy_balance0.85340617
102MP0001765_abnormal_ion_homeostasis0.82578513
103MP0001756_abnormal_urination0.82572325
104MP0005334_abnormal_fat_pad0.80590828
105MP0005636_abnormal_mineral_homeostasis0.78529563
106MP0000604_amyloidosis0.77676744
107MP0002876_abnormal_thyroid_physiology0.77209248
108MP0003656_abnormal_erythrocyte_physiolo0.76570381
109MP0002080_prenatal_lethality0.76196080
110MP0005501_abnormal_skin_physiology0.74660981
111MP0004270_analgesia0.73997349
112MP0003705_abnormal_hypodermis_morpholog0.73949448
113MP0004924_abnormal_behavior0.73218603
114MP0005386_behavior/neurological_phenoty0.73218603
115MP0002063_abnormal_learning/memory/cond0.72815447
116MP0008872_abnormal_physiological_respon0.71793659
117MP0008874_decreased_physiological_sensi0.71564435
118MP0002272_abnormal_nervous_system0.71333407
119MP0001727_abnormal_embryo_implantation0.70662922
120MP0004782_abnormal_surfactant_physiolog0.68539816
121MP0003690_abnormal_glial_cell0.68295025
122MP0003984_embryonic_growth_retardation0.67859380
123MP0005165_increased_susceptibility_to0.67250819
124MP0003953_abnormal_hormone_level0.66722355
125MP0000350_abnormal_cell_proliferation0.66483805
126MP0001849_ear_inflammation0.65952612
127MP0004858_abnormal_nervous_system0.65848923
128MP0008058_abnormal_DNA_repair0.65181520
129MP0002108_abnormal_muscle_morphology0.64738438
130MP0005376_homeostasis/metabolism_phenot0.64326723
131MP0002088_abnormal_embryonic_growth/wei0.62905869
132MP0003186_abnormal_redox_activity0.62885551
133MP0002970_abnormal_white_adipose0.62765075
134MP0005452_abnormal_adipose_tissue0.62761174
135MP0003633_abnormal_nervous_system0.62583331
136MP0003763_abnormal_thymus_physiology0.62001368

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.14989830
2Muscle fiber inclusion bodies (HP:0100299)5.11398426
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.02663596
4Myoglobinuria (HP:0002913)4.80706612
5Exercise-induced myalgia (HP:0003738)4.51531515
6Centrally nucleated skeletal muscle fibers (HP:0003687)4.38017329
7Ketoacidosis (HP:0001993)4.30810447
8Distal lower limb muscle weakness (HP:0009053)4.11255022
9Sudden death (HP:0001699)4.09722317
10Hypoglycemic coma (HP:0001325)4.06914313
11Exercise-induced muscle cramps (HP:0003710)4.06849698
12Ketosis (HP:0001946)4.05769620
13Abnormality of fatty-acid metabolism (HP:0004359)3.94011869
14Hyperglycinuria (HP:0003108)3.92179211
15Hyperammonemia (HP:0001987)3.90163153
16Progressive muscle weakness (HP:0003323)3.78841698
17Myopathic facies (HP:0002058)3.78728010
18Increased connective tissue (HP:0009025)3.71126769
19Abnormality of serine family amino acid metabolism (HP:0010894)3.54837166
20Abnormality of glycine metabolism (HP:0010895)3.54837166
21Rhabdomyolysis (HP:0003201)3.51465249
22Type 1 muscle fiber predominance (HP:0003803)3.51130137
23Dicarboxylic aciduria (HP:0003215)3.47116338
24Abnormality of dicarboxylic acid metabolism (HP:0010995)3.47116338
25Distal lower limb amyotrophy (HP:0008944)3.46344915
26Palpitations (HP:0001962)3.32203843
27Neck muscle weakness (HP:0000467)3.30203080
28Calf muscle hypertrophy (HP:0008981)3.28566712
29Cerebral edema (HP:0002181)3.18985135
30Acute encephalopathy (HP:0006846)3.16935351
31* Hepatic necrosis (HP:0002605)3.12136040
32Gout (HP:0001997)3.11086194
33Pheochromocytoma (HP:0002666)3.10359244
34Muscle hypertrophy of the lower extremities (HP:0008968)3.08586235
35Hyperglycinemia (HP:0002154)3.05693187
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.99468374
37Ventricular tachycardia (HP:0004756)2.96731656
38Abnormality of glycolysis (HP:0004366)2.95995428
39Increased serum pyruvate (HP:0003542)2.95995428
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.92955549
41Generalized aminoaciduria (HP:0002909)2.88395565
42Xanthomatosis (HP:0000991)2.82884460
43Neuroendocrine neoplasm (HP:0100634)2.79794641
44Metabolic acidosis (HP:0001942)2.78496242
45Acute necrotizing encephalopathy (HP:0006965)2.77147486
46* Abnormal mitochondria in muscle tissue (HP:0008316)2.70010404
47Intrahepatic cholestasis (HP:0001406)2.69295112
48Lethargy (HP:0001254)2.68711439
49Atrial fibrillation (HP:0005110)2.68592219
50Deep venous thrombosis (HP:0002625)2.65823607
51Abnormality of the calf musculature (HP:0001430)2.63970463
52Conjunctival hamartoma (HP:0100780)2.61941493
53Asymmetric septal hypertrophy (HP:0001670)2.59605340
54Syncope (HP:0001279)2.58242607
55Abnormality of alanine metabolism (HP:0010916)2.57194185
56Hyperalaninemia (HP:0003348)2.57194185
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57194185
58Right ventricular cardiomyopathy (HP:0011663)2.53919599
59* Lactic acidosis (HP:0003128)2.53594715
60Bundle branch block (HP:0011710)2.53338991
61Abnormality of skeletal muscle fiber size (HP:0012084)2.51720862
62Cholelithiasis (HP:0001081)2.49825398
63Primary atrial arrhythmia (HP:0001692)2.47553799
64Muscle fiber splitting (HP:0003555)2.45869865
65Hyporeflexia of lower limbs (HP:0002600)2.44620683
66Oligomenorrhea (HP:0000876)2.43031171
67Abnormal atrioventricular conduction (HP:0005150)2.42741452
68Hypoalphalipoproteinemia (HP:0003233)2.42650366
69Reticulocytosis (HP:0001923)2.42496537
70Hyperlipoproteinemia (HP:0010980)2.42221389
71Progressive macrocephaly (HP:0004481)2.40426513
72* Hepatocellular necrosis (HP:0001404)2.39620208
73Mildly elevated creatine phosphokinase (HP:0008180)2.39578288
74Supraventricular tachycardia (HP:0004755)2.39034353
75Hypobetalipoproteinemia (HP:0003563)2.38120864
76Muscle stiffness (HP:0003552)2.37735056
77* Lipoatrophy (HP:0100578)2.37563904
78Abnormality of glutamine family amino acid metabolism (HP:0010902)2.37173033
79Ventricular arrhythmia (HP:0004308)2.36183187
80Abnormal gallbladder morphology (HP:0012437)2.34216360
81Vomiting (HP:0002013)2.33906154
82Supraventricular arrhythmia (HP:0005115)2.33608245
83Achilles tendon contracture (HP:0001771)2.33147340
84Hypolipoproteinemia (HP:0010981)2.31657365
85Ventricular fibrillation (HP:0001663)2.30822309
86Abnormal gallbladder physiology (HP:0012438)2.30394172
87Cholecystitis (HP:0001082)2.30394172
88Microvesicular hepatic steatosis (HP:0001414)2.29797691
89Ulnar deviation of the wrist (HP:0003049)2.29625582
90Calcaneovalgus deformity (HP:0001848)2.29511970
91Increased purine levels (HP:0004368)2.28688684
92Hyperuricemia (HP:0002149)2.28688684
93Dysmetric saccades (HP:0000641)2.28513211
94Abnormality of serum amino acid levels (HP:0003112)2.28192292
95Proximal tubulopathy (HP:0000114)2.28030450
96Prolonged QT interval (HP:0001657)2.27442243
97Difficulty running (HP:0009046)2.25817371
98Abnormality of purine metabolism (HP:0004352)2.25452256
99* Increased CSF lactate (HP:0002490)2.23094357
100Myotonia (HP:0002486)2.22938871
101* Increased muscle lipid content (HP:0009058)2.22922030
102EMG: myopathic abnormalities (HP:0003458)2.22194847
103Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21996380
104Lower limb amyotrophy (HP:0007210)2.21445675
105Atrioventricular block (HP:0001678)2.20922610
106Abnormality of the Achilles tendon (HP:0005109)2.20329428
107* Dilated cardiomyopathy (HP:0001644)2.18977462
108Rimmed vacuoles (HP:0003805)2.18713663
109Heart block (HP:0012722)2.18156677
110Neoplasm of the adrenal gland (HP:0100631)2.16798687
111EMG: neuropathic changes (HP:0003445)2.14319872
112Foot dorsiflexor weakness (HP:0009027)2.12109692
113Hyperinsulinemic hypoglycemia (HP:0000825)2.11337795
114Vertebral compression fractures (HP:0002953)2.10177566
115Difficulty climbing stairs (HP:0003551)2.09852923
116Methylmalonic aciduria (HP:0012120)2.08963706
117Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.08490316
118Areflexia of lower limbs (HP:0002522)2.07062070
119Abnormality of the foot musculature (HP:0001436)2.06535039
120Abnormality of the left ventricular outflow tract (HP:0011103)2.06500393
121Subaortic stenosis (HP:0001682)2.06500393
122* Mitochondrial inheritance (HP:0001427)2.06074790
123Hyperventilation (HP:0002883)2.05702629
124Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05039178
125* Ragged-red muscle fibers (HP:0003200)2.05013286
126Distal arthrogryposis (HP:0005684)2.04430706
127Hamartoma of the eye (HP:0010568)2.03418505
128Generalized muscle weakness (HP:0003324)2.02750807
129Skin nodule (HP:0200036)2.02599527
130Complement deficiency (HP:0004431)2.01706288
131Abnormality of the tricuspid valve (HP:0001702)1.99320478
132Increased variability in muscle fiber diameter (HP:0003557)1.99272444
133Trismus (HP:0000211)1.94943489
134Deformed tarsal bones (HP:0008119)1.90364991
135Bulbar palsy (HP:0001283)1.88527078
136Reduced antithrombin III activity (HP:0001976)1.86713753
137Abnormality of the calcaneus (HP:0008364)1.86164986
138Reduced subcutaneous adipose tissue (HP:0003758)1.85396386
139* Exercise intolerance (HP:0003546)1.85164627
140Progressive external ophthalmoplegia (HP:0000590)1.84719472
141Hyperacusis (HP:0010780)1.77103810
142Scapular winging (HP:0003691)1.73724981
143Back pain (HP:0003418)1.71494029
144Abnormality of reticulocytes (HP:0004312)1.71007103
145Elbow flexion contracture (HP:0002987)1.68854868
146Hemorrhage of the eye (HP:0011885)1.68247554
147Round ear (HP:0100830)1.64426124
148Testicular atrophy (HP:0000029)1.64403708
149Cerebral palsy (HP:0100021)1.60552461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.47803025
2PDK34.32629146
3PDK44.32629146
4NEK13.27349452
5LMTK23.24542236
6TRIB33.17281842
7PKN22.92885748
8TTN2.85194785
9PHKG22.77734396
10PHKG12.77734396
11SCYL22.67995328
12OBSCN2.66053163
13TESK22.55312183
14NME22.55302276
15PDK22.41404438
16EEF2K2.26540964
17EPHA22.24559474
18ICK2.24035105
19MYLK2.18784037
20MAP2K42.08151092
21ARAF2.05873122
22PINK11.95227109
23SMG11.89142346
24PBK1.85783235
25MAPKAPK31.84741932
26MAP3K41.75964035
27RPS6KB21.68373299
28IRAK31.68348308
29MET1.61215503
30NTRK31.57874958
31EIF2AK11.55155981
32WNK41.53323830
33PIM21.49796493
34INSRR1.41848128
35SIK11.35624382
36TESK11.35307115
37CDK121.33874284
38PRPF4B1.30858962
39MAP3K71.29367361
40DAPK21.29037960
41BUB11.21839768
42OXSR11.17420718
43KSR21.13713008
44TIE11.12523361
45STK381.09483814
46RAF11.09102312
47EPHA41.08129914
48MAP3K131.01392277
49MAP3K120.97391403
50MINK10.96832690
51RIPK10.96484471
52WNK30.93686456
53CDC70.93503462
54MAP3K90.93313335
55PRKD30.93310349
56FLT30.93010895
57PDPK10.92894861
58PAK30.92621509
59LIMK10.92259959
60PIK3CA0.92162229
61PDK10.90899930
62SGK30.90120016
63MAP2K70.89732618
64DMPK0.88270128
65CDK80.87234452
66DAPK10.85870568
67AKT20.85588458
68MAPK120.84515120
69KDR0.84064325
70PRKCH0.83673110
71BRSK10.81635498
72PRKAA10.81435076
73CAMKK10.81394618
74MAP2K20.80870240
75PAK40.79449136
76SGK2230.79101048
77SGK4940.79101048
78PAK60.78870618
79PRKAA20.78587427
80CAMK1D0.77775055
81SGK20.75899124
82CAMK2D0.74316856
83ERN10.74176255
84BRAF0.73927142
85MAP2K30.73676354
86TTK0.72247456
87MTOR0.71807054
88CCNB10.71600268
89TRPM70.69041241
90FGFR40.66859677
91CAMK2G0.66729444
92RET0.66635045
93AURKB0.64119831
94MAP3K80.63843457
95CAMK40.62606555
96MAPK110.62031578
97CAMK2A0.61368587
98CAMK10.61257951
99PRKACG0.60956069
100MUSK0.60919415
101CAMK2B0.60803245
102AURKA0.59754849
103TBK10.58440156
104MAP2K10.57454079
105CAMK1G0.56688909
106PTK60.56628654
107CDK40.56277768
108PRKD10.55020505
109PTK2B0.54650089
110GRK70.53628517
111MAP3K110.53009413
112TAOK20.52617073
113CAMKK20.52397547
114NEK60.51742099
115CDK70.51729905
116NME10.51687593
117STK240.50817256
118PTK20.50178006
119ILK0.49963640
120PRKCG0.49247213
121ABL20.49204806
122MAP2K60.47743456
123JAK20.47619991
124MST1R0.47500184
125DAPK30.46656552
126MAP3K50.46626457
127FRK0.46088566
128STK38L0.44858410
129PRKCI0.44528850
130ATR0.44476776
131ROCK10.44406558
132CDK50.44108405
133PRKACB0.43440983
134CDK190.41882162
135MAP3K10.39845450
136EPHB10.39670079
137PRKACA0.39262071
138FER0.39001204
139KSR10.38240023
140PAK10.37940388
141WNK10.37606695
142RPS6KA30.36390427
143NTRK10.35445839
144SGK10.35353973
145LATS20.35269735
146STK40.35207027
147NEK90.35118126
148PDGFRA0.34959986
149ERBB40.34655485
150CDC42BPA0.33911650
151MAPKAPK50.33864677
152CHEK10.32751607
153MAP3K20.32620074
154GRK50.31823689
155MAP3K30.31262935
156BMX0.28805063
157PRKG20.28619630
158CDK90.27326882

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.61398257
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.85558041
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.49366261
4Propanoate metabolism_Homo sapiens_hsa006403.43686806
5Fatty acid degradation_Homo sapiens_hsa000713.11571841
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.98891428
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81012903
8Fatty acid metabolism_Homo sapiens_hsa012122.56657630
9Butanoate metabolism_Homo sapiens_hsa006502.54659334
10Pyruvate metabolism_Homo sapiens_hsa006202.50023484
11Nitrogen metabolism_Homo sapiens_hsa009102.41558864
12* Carbon metabolism_Homo sapiens_hsa012002.37703751
13DNA replication_Homo sapiens_hsa030302.29204611
14Arginine biosynthesis_Homo sapiens_hsa002202.17732159
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.02797981
16Sulfur relay system_Homo sapiens_hsa041221.97572271
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97450232
18Tryptophan metabolism_Homo sapiens_hsa003801.91093250
19PPAR signaling pathway_Homo sapiens_hsa033201.80768084
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73897162
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73609763
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66167289
23Biosynthesis of amino acids_Homo sapiens_hsa012301.66076524
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57786014
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53833770
26beta-Alanine metabolism_Homo sapiens_hsa004101.52298104
27Fatty acid elongation_Homo sapiens_hsa000621.52024655
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51424373
29Peroxisome_Homo sapiens_hsa041461.50556908
30Cardiac muscle contraction_Homo sapiens_hsa042601.41743990
31* Oxidative phosphorylation_Homo sapiens_hsa001901.37368621
32Base excision repair_Homo sapiens_hsa034101.35275580
33Mismatch repair_Homo sapiens_hsa034301.31989275
34Other glycan degradation_Homo sapiens_hsa005111.31464292
35Proteasome_Homo sapiens_hsa030501.29202823
36Parkinsons disease_Homo sapiens_hsa050121.29079474
37Starch and sucrose metabolism_Homo sapiens_hsa005001.24948277
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20104118
39Bile secretion_Homo sapiens_hsa049761.16563551
40Phenylalanine metabolism_Homo sapiens_hsa003601.09394614
41Fatty acid biosynthesis_Homo sapiens_hsa000611.04838227
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03049180
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.02359003
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02197477
45One carbon pool by folate_Homo sapiens_hsa006700.93272020
46Alzheimers disease_Homo sapiens_hsa050100.92321425
47Sulfur metabolism_Homo sapiens_hsa009200.92116335
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88155655
49Dilated cardiomyopathy_Homo sapiens_hsa054140.86745528
50Glucagon signaling pathway_Homo sapiens_hsa049220.84492528
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84425375
52* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81471439
53Tyrosine metabolism_Homo sapiens_hsa003500.80203579
54Glycerolipid metabolism_Homo sapiens_hsa005610.79193796
55Fructose and mannose metabolism_Homo sapiens_hsa000510.77630274
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77342317
57Fat digestion and absorption_Homo sapiens_hsa049750.77050002
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76763535
59Folate biosynthesis_Homo sapiens_hsa007900.76410874
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75840397
61Nucleotide excision repair_Homo sapiens_hsa034200.74470578
62N-Glycan biosynthesis_Homo sapiens_hsa005100.74414541
63Complement and coagulation cascades_Homo sapiens_hsa046100.71989238
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71737992
65Synaptic vesicle cycle_Homo sapiens_hsa047210.71690601
66Arginine and proline metabolism_Homo sapiens_hsa003300.69262921
67Pyrimidine metabolism_Homo sapiens_hsa002400.68557830
68Glutathione metabolism_Homo sapiens_hsa004800.68161045
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.67041163
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.66850489
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66686088
72Histidine metabolism_Homo sapiens_hsa003400.63989495
73Pentose phosphate pathway_Homo sapiens_hsa000300.63929514
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63566467
75Galactose metabolism_Homo sapiens_hsa000520.62303107
76Lysine degradation_Homo sapiens_hsa003100.61128438
77Collecting duct acid secretion_Homo sapiens_hsa049660.61077680
78Insulin resistance_Homo sapiens_hsa049310.60418213
79Caffeine metabolism_Homo sapiens_hsa002320.59945865
80Prion diseases_Homo sapiens_hsa050200.59835743
81Chemical carcinogenesis_Homo sapiens_hsa052040.59612873
82Huntingtons disease_Homo sapiens_hsa050160.58367825
83Selenocompound metabolism_Homo sapiens_hsa004500.57310452
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53682189
85GABAergic synapse_Homo sapiens_hsa047270.53182762
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53086403
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.52797127
88Insulin signaling pathway_Homo sapiens_hsa049100.52708796
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.52665029
90ABC transporters_Homo sapiens_hsa020100.51877347
91AMPK signaling pathway_Homo sapiens_hsa041520.48125847
92Insulin secretion_Homo sapiens_hsa049110.47738498
93Gastric acid secretion_Homo sapiens_hsa049710.44930556
94Purine metabolism_Homo sapiens_hsa002300.42499127
95* Metabolic pathways_Homo sapiens_hsa011000.41241104
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.40046539
97Renin secretion_Homo sapiens_hsa049240.39703307
98Thyroid cancer_Homo sapiens_hsa052160.39648140
99Circadian entrainment_Homo sapiens_hsa047130.39180331
100Renin-angiotensin system_Homo sapiens_hsa046140.39107403
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37989386
102Nicotine addiction_Homo sapiens_hsa050330.36082881
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35461836
104Type II diabetes mellitus_Homo sapiens_hsa049300.34558736
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33431092
106Retinol metabolism_Homo sapiens_hsa008300.33382523
107Bladder cancer_Homo sapiens_hsa052190.33338119
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33159012
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32915407
110Calcium signaling pathway_Homo sapiens_hsa040200.32698386
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32058540
112Olfactory transduction_Homo sapiens_hsa047400.32015543
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31587820
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.31441078
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30534797
116Salivary secretion_Homo sapiens_hsa049700.29997813
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27625400
118Morphine addiction_Homo sapiens_hsa050320.27450358
119Cell cycle_Homo sapiens_hsa041100.27114038
120Vitamin B6 metabolism_Homo sapiens_hsa007500.26925749
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25208547
122Long-term potentiation_Homo sapiens_hsa047200.24351284
123Non-homologous end-joining_Homo sapiens_hsa034500.23814764
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22885955
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22445903
126RNA transport_Homo sapiens_hsa030130.22197052
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22173583
128Amphetamine addiction_Homo sapiens_hsa050310.22152926
129Vitamin digestion and absorption_Homo sapiens_hsa049770.21581656
130Vibrio cholerae infection_Homo sapiens_hsa051100.20836538
131Non-small cell lung cancer_Homo sapiens_hsa052230.19421538
132Spliceosome_Homo sapiens_hsa030400.19247567

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