SDHAF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.53048923
2energy coupled proton transport, down electrochemical gradient (GO:0015985)7.08557424
3ATP synthesis coupled proton transport (GO:0015986)7.08557424
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.96854158
5respiratory electron transport chain (GO:0022904)6.26104525
6electron transport chain (GO:0022900)6.11234952
7chaperone-mediated protein transport (GO:0072321)5.39620312
8protein complex biogenesis (GO:0070271)5.37816242
9mitochondrial respiratory chain complex assembly (GO:0033108)5.04314115
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.96346182
11NADH dehydrogenase complex assembly (GO:0010257)4.96346182
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.96346182
13regulation of mitochondrial translation (GO:0070129)4.57310146
14protein-cofactor linkage (GO:0018065)4.28947441
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.28642338
16protein neddylation (GO:0045116)4.27934090
17cullin deneddylation (GO:0010388)4.18809206
18inner mitochondrial membrane organization (GO:0007007)4.04425899
19ribosomal large subunit biogenesis (GO:0042273)3.92591077
20oxidative phosphorylation (GO:0006119)3.90209445
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.87566212
22chromatin remodeling at centromere (GO:0031055)3.84745712
23CENP-A containing nucleosome assembly (GO:0034080)3.83228749
24neuron cell-cell adhesion (GO:0007158)3.79793155
25establishment of integrated proviral latency (GO:0075713)3.78489078
26respiratory chain complex IV assembly (GO:0008535)3.76612834
27positive regulation of mitochondrial fission (GO:0090141)3.75372151
28ATP biosynthetic process (GO:0006754)3.74956863
29purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.74802358
30GTP biosynthetic process (GO:0006183)3.74261592
31protein deneddylation (GO:0000338)3.73993240
32hydrogen ion transmembrane transport (GO:1902600)3.73247833
33DNA replication checkpoint (GO:0000076)3.72089815
34dopamine transport (GO:0015872)3.71615166
35purine nucleoside triphosphate biosynthetic process (GO:0009145)3.71504580
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.69648989
37cytochrome complex assembly (GO:0017004)3.68567691
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.66644687
39telomere maintenance via semi-conservative replication (GO:0032201)3.64618394
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64590969
41presynaptic membrane assembly (GO:0097105)3.61348047
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.60074668
43protein targeting to mitochondrion (GO:0006626)3.59257333
44pseudouridine synthesis (GO:0001522)3.57500569
45DNA strand elongation involved in DNA replication (GO:0006271)3.51515155
46ribosomal small subunit biogenesis (GO:0042274)3.51382045
47purine nucleobase biosynthetic process (GO:0009113)3.48886826
48establishment of protein localization to mitochondrion (GO:0072655)3.45521394
49translation (GO:0006412)3.44449205
50quinone biosynthetic process (GO:1901663)3.42814957
51ubiquinone biosynthetic process (GO:0006744)3.42814957
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.42738554
53spliceosomal snRNP assembly (GO:0000387)3.38303518
54maturation of 5.8S rRNA (GO:0000460)3.38208049
55proton transport (GO:0015992)3.36991439
56rRNA methylation (GO:0031167)3.35985844
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35032458
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34598533
59presynaptic membrane organization (GO:0097090)3.33992902
60DNA double-strand break processing (GO:0000729)3.33900528
61DNA strand elongation (GO:0022616)3.33235148
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.32765252
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.32765252
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.32765252
65protein localization to mitochondrion (GO:0070585)3.31132022
66ribonucleoside triphosphate biosynthetic process (GO:0009201)3.31096014
67hydrogen transport (GO:0006818)3.29458608
68signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29360942
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29360942
70guanosine-containing compound biosynthetic process (GO:1901070)3.27294873
71ATP hydrolysis coupled proton transport (GO:0015991)3.26757295
72energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.26757295
73transcription elongation from RNA polymerase III promoter (GO:0006385)3.25649234
74termination of RNA polymerase III transcription (GO:0006386)3.25649234
75nucleobase biosynthetic process (GO:0046112)3.24632418
76ribosomal small subunit assembly (GO:0000028)3.24565043
77mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.23797458
78translational initiation (GO:0006413)3.23238660
79translational elongation (GO:0006414)3.22887358
80IMP biosynthetic process (GO:0006188)3.22328797
81positive regulation of ligase activity (GO:0051351)3.21838899
82signal transduction involved in DNA damage checkpoint (GO:0072422)3.21616933
83signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21616933
84negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20604578
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.19315365
86proteasome assembly (GO:0043248)3.19102813
87ubiquinone metabolic process (GO:0006743)3.18528582
88rRNA processing (GO:0006364)3.18120831
89nucleotide-excision repair, DNA gap filling (GO:0006297)3.16941633
90aerobic respiration (GO:0009060)3.15967537
91succinate metabolic process (GO:0006105)3.14121664
92histone exchange (GO:0043486)3.13821269
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13297906
94tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13297906
95telomere maintenance via recombination (GO:0000722)3.13194316
96transcription from mitochondrial promoter (GO:0006390)3.12498275
97protein localization to synapse (GO:0035418)3.12256228
98transcription-coupled nucleotide-excision repair (GO:0006283)3.11407100
99establishment of viral latency (GO:0019043)3.11240674
100histone mRNA metabolic process (GO:0008334)3.10587600
101regulation of helicase activity (GO:0051095)3.07467987
102NADH metabolic process (GO:0006734)3.07305826
103DNA catabolic process, exonucleolytic (GO:0000738)3.06362984
1047-methylguanosine mRNA capping (GO:0006370)3.06045390
105ribosome assembly (GO:0042255)3.05313767
106rRNA metabolic process (GO:0016072)3.05182043
107UTP biosynthetic process (GO:0006228)3.04899802
108regulation of ubiquitin-protein transferase activity (GO:0051438)3.04076298
109mitotic metaphase plate congression (GO:0007080)3.03461289
1107-methylguanosine RNA capping (GO:0009452)3.03373853
111RNA capping (GO:0036260)3.03373853
112DNA damage response, detection of DNA damage (GO:0042769)3.02697129
113peptidyl-histidine modification (GO:0018202)3.01761076
114mitotic recombination (GO:0006312)3.01532319
115L-methionine salvage (GO:0071267)2.99788492
116L-methionine biosynthetic process (GO:0071265)2.99788492
117amino acid salvage (GO:0043102)2.99788492
118neurotransmitter uptake (GO:0001504)2.99506517
119tricarboxylic acid cycle (GO:0006099)2.97377826
120nucleoside triphosphate biosynthetic process (GO:0009142)2.97065011
121mitochondrial transport (GO:0006839)2.95148461
122regulation of acyl-CoA biosynthetic process (GO:0050812)2.94507622
123synaptic vesicle exocytosis (GO:0016079)2.91193409
124regulation of cellular amino acid metabolic process (GO:0006521)2.87049472
125neuronal action potential propagation (GO:0019227)2.84328608
126startle response (GO:0001964)2.83326607
127positive regulation of synapse assembly (GO:0051965)2.81703104
128negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80557568
129cellular respiration (GO:0045333)2.79439167
130quinone metabolic process (GO:1901661)2.78552757
131maturation of SSU-rRNA (GO:0030490)2.77001964
132viral transcription (GO:0019083)2.76050202
133negative regulation of dendrite morphogenesis (GO:0050774)2.74340906
134translational termination (GO:0006415)2.73875256
135UTP metabolic process (GO:0046051)2.73151069
136CTP metabolic process (GO:0046036)2.72859186
137CTP biosynthetic process (GO:0006241)2.72859186
138regulation of cofactor metabolic process (GO:0051193)2.71681761
139regulation of coenzyme metabolic process (GO:0051196)2.71681761
140vocalization behavior (GO:0071625)2.71378443
141cotranslational protein targeting to membrane (GO:0006613)2.71269428
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69392624
143rRNA modification (GO:0000154)2.66777659
144intracellular protein transmembrane import (GO:0044743)2.64857926
145cellular component biogenesis (GO:0044085)2.64564699
146protein localization to endoplasmic reticulum (GO:0070972)2.63766668
147regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.63422078
148regulation of mitochondrial fission (GO:0090140)2.62971011
149regulation of cellular respiration (GO:0043457)2.60713913
150regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60312478
151negative regulation of ligase activity (GO:0051352)2.60009559
152negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60009559
153SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.59257604
154protein targeting to ER (GO:0045047)2.58785820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.78662628
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24401119
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.70952934
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37996987
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35971605
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.34648258
7EZH2_22144423_ChIP-Seq_EOC_Human3.31994228
8TAF15_26573619_Chip-Seq_HEK293_Human3.23832411
9GBX2_23144817_ChIP-Seq_PC3_Human3.13311867
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.11462616
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03793202
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69974244
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69326685
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68445394
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63474607
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.37964652
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37607802
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35862754
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27938775
20FUS_26573619_Chip-Seq_HEK293_Human2.23738573
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14579604
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14311585
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13366918
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99981700
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98029613
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.93298638
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.90879563
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90268574
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.86137425
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85965830
31VDR_22108803_ChIP-Seq_LS180_Human1.85221088
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75407934
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72729330
34VDR_23849224_ChIP-Seq_CD4+_Human1.70709493
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66323761
36DCP1A_22483619_ChIP-Seq_HELA_Human1.66219442
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59779720
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58978361
39EWS_26573619_Chip-Seq_HEK293_Human1.56958338
40FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.55754063
41P300_19829295_ChIP-Seq_ESCs_Human1.54933981
42FOXP3_21729870_ChIP-Seq_TREG_Human1.54758744
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.54410394
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54346406
45ELK1_19687146_ChIP-ChIP_HELA_Human1.54029667
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52952261
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51192815
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50715961
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49201114
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.48929735
51AR_21909140_ChIP-Seq_LNCAP_Human1.47244402
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45835686
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.45111632
54ER_23166858_ChIP-Seq_MCF-7_Human1.43749776
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43278984
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41672656
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41456527
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39565036
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38984410
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36781421
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36055072
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35869142
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34101221
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.32799574
65ZNF274_21170338_ChIP-Seq_K562_Hela1.29716204
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29692374
67IGF1R_20145208_ChIP-Seq_DFB_Human1.28714510
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26254711
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26028300
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.25521320
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25464004
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25092181
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25021806
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24971700
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24214793
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21076683
77MYC_18940864_ChIP-ChIP_HL60_Human1.20345125
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.18082058
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17741400
80REST_21632747_ChIP-Seq_MESCs_Mouse1.16994583
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16543788
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13926799
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13685378
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13509591
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13357010
86KDM5A_27292631_Chip-Seq_BREAST_Human1.13333637
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12539964
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.12484254
89TTF2_22483619_ChIP-Seq_HELA_Human1.12179309
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.11640367
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11170901
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11155472
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10888352
94IRF1_19129219_ChIP-ChIP_H3396_Human1.09297653
95RNF2_27304074_Chip-Seq_NSC_Mouse1.08914788
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07273464
97HTT_18923047_ChIP-ChIP_STHdh_Human1.06208693
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06198191
99XRN2_22483619_ChIP-Seq_HELA_Human1.06166220
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06059283
101JUN_21703547_ChIP-Seq_K562_Human1.06028670
102REST_18959480_ChIP-ChIP_MESCs_Mouse1.05603454
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03352594
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01612075
105GABP_19822575_ChIP-Seq_HepG2_Human1.00937667
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00495448
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.99741790
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98975317
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97658700
110REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97650807
111NANOG_18555785_Chip-Seq_ESCs_Mouse0.95858302
112FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95487585
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94590708
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.94373690
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94024414
116SMAD4_21799915_ChIP-Seq_A2780_Human0.93902770
117POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93545483
118SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92906470
119EED_16625203_ChIP-ChIP_MESCs_Mouse0.91977737
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.91734251
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91337830
122SALL1_21062744_ChIP-ChIP_HESCs_Human0.90547455
123SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90181256
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89905195
125JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89838840
126P53_22387025_ChIP-Seq_ESCs_Mouse0.89821499
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89241515
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87830446
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87480311
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86915889
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86710998
132SMAD3_21741376_ChIP-Seq_EPCs_Human0.86167634
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81058388
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.80413156
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78265428
136TP53_22573176_ChIP-Seq_HFKS_Human0.77042335
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77040938
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72236765
139KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.71921958
140CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.67568224
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.65774840
142TFEB_21752829_ChIP-Seq_HELA_Human0.64371070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.33553145
2MP0008058_abnormal_DNA_repair4.60600404
3MP0009379_abnormal_foot_pigmentation4.03293204
4MP0010094_abnormal_chromosome_stability3.85847164
5MP0003693_abnormal_embryo_hatching3.63903532
6MP0001529_abnormal_vocalization3.56698884
7MP0006276_abnormal_autonomic_nervous3.42143116
8MP0004957_abnormal_blastocyst_morpholog3.38169972
9MP0003111_abnormal_nucleus_morphology2.80461879
10MP0009046_muscle_twitch2.68982732
11MP0006292_abnormal_olfactory_placode2.66858948
12MP0003077_abnormal_cell_cycle2.63817647
13MP0001968_abnormal_touch/_nociception2.60161300
14MP0002736_abnormal_nociception_after2.57495792
15MP0003186_abnormal_redox_activity2.49085105
16MP0004859_abnormal_synaptic_plasticity2.44521700
17MP0009745_abnormal_behavioral_response2.42366620
18MP0001188_hyperpigmentation2.41791544
19MP0004270_analgesia2.40247605
20MP0003635_abnormal_synaptic_transmissio2.38996980
21MP0002272_abnormal_nervous_system2.32471416
22MP0001905_abnormal_dopamine_level2.31785340
23MP0002064_seizures2.28479940
24MP0006035_abnormal_mitochondrial_morpho2.20421277
25MP0003786_premature_aging2.17450827
26MP0008007_abnormal_cellular_replicative2.07500455
27MP0005423_abnormal_somatic_nervous2.05814598
28MP0002572_abnormal_emotion/affect_behav2.05633197
29MP0004142_abnormal_muscle_tone2.01033605
30MP0006036_abnormal_mitochondrial_physio2.00907137
31MP0008057_abnormal_DNA_replication1.96015652
32MP0002734_abnormal_mechanical_nocicepti1.93980830
33MP0002063_abnormal_learning/memory/cond1.93665619
34MP0002735_abnormal_chemical_nociception1.93119953
35MP0002837_dystrophic_cardiac_calcinosis1.93079690
36MP0009697_abnormal_copulation1.91714290
37MP0005646_abnormal_pituitary_gland1.88912748
38MP0001984_abnormal_olfaction1.88716422
39MP0001486_abnormal_startle_reflex1.86679099
40MP0002067_abnormal_sensory_capabilities1.78747993
41MP0001986_abnormal_taste_sensitivity1.78325965
42MP0001293_anophthalmia1.75004180
43MP0008995_early_reproductive_senescence1.71905332
44MP0001501_abnormal_sleep_pattern1.71561418
45MP0003122_maternal_imprinting1.68731401
46MP0001440_abnormal_grooming_behavior1.63948460
47MP0005386_behavior/neurological_phenoty1.61844923
48MP0004924_abnormal_behavior1.61844923
49MP0002822_catalepsy1.54276514
50MP0002184_abnormal_innervation1.49602948
51MP0004147_increased_porphyrin_level1.48045289
52MP0005075_abnormal_melanosome_morpholog1.45009986
53MP0005408_hypopigmentation1.42251864
54MP0003567_abnormal_fetal_cardiomyocyte1.41872598
55MP0005394_taste/olfaction_phenotype1.40022409
56MP0005499_abnormal_olfactory_system1.40022409
57MP0002557_abnormal_social/conspecific_i1.34209055
58MP0002638_abnormal_pupillary_reflex1.32289781
59MP0001970_abnormal_pain_threshold1.31604125
60MP0004145_abnormal_muscle_electrophysio1.30720374
61MP0003806_abnormal_nucleotide_metabolis1.29048582
62MP0003646_muscle_fatigue1.27984255
63MP0001929_abnormal_gametogenesis1.25958197
64MP0002733_abnormal_thermal_nociception1.25581105
65MP0008789_abnormal_olfactory_epithelium1.25312433
66MP0000778_abnormal_nervous_system1.23950830
67MP0002210_abnormal_sex_determination1.23755943
68MP0008872_abnormal_physiological_respon1.23284913
69MP0005409_darkened_coat_color1.22629133
70MP0003011_delayed_dark_adaptation1.18584830
71MP0002234_abnormal_pharynx_morphology1.17383998
72MP0005084_abnormal_gallbladder_morpholo1.15332495
73MP0004036_abnormal_muscle_relaxation1.15198689
74MP0002876_abnormal_thyroid_physiology1.12296734
75MP0000749_muscle_degeneration1.11704082
76MP0004215_abnormal_myocardial_fiber1.11183467
77MP0003937_abnormal_limbs/digits/tail_de1.11176400
78MP0005410_abnormal_fertilization1.11066784
79MP0005645_abnormal_hypothalamus_physiol1.09368061
80MP0000358_abnormal_cell_content/1.08803313
81MP0001697_abnormal_embryo_size1.08646959
82MP0001485_abnormal_pinna_reflex1.06964732
83MP0001730_embryonic_growth_arrest1.06913934
84MP0000653_abnormal_sex_gland1.05843988
85MP0002095_abnormal_skin_pigmentation1.05484275
86MP0002066_abnormal_motor_capabilities/c1.04586120
87MP0004484_altered_response_of1.03723668
88MP0001145_abnormal_male_reproductive1.02965726
89MP0003195_calcinosis1.02725549
90MP0000955_abnormal_spinal_cord1.01614061
91MP0003137_abnormal_impulse_conducting1.00300430
92MP0003123_paternal_imprinting1.00157782
93MP0001286_abnormal_eye_development0.98872904
94MP0002882_abnormal_neuron_morphology0.97611159
95MP0010030_abnormal_orbit_morphology0.97465529
96MP0000350_abnormal_cell_proliferation0.95902282
97MP0005551_abnormal_eye_electrophysiolog0.95892923
98MP0008569_lethality_at_weaning0.94570664
99MP0010386_abnormal_urinary_bladder0.92387545
100MP0000049_abnormal_middle_ear0.91512205
101MP0004085_abnormal_heartbeat0.91265305
102MP0003698_abnormal_male_reproductive0.91202307
103MP0005535_abnormal_body_temperature0.90215330
104MP0008877_abnormal_DNA_methylation0.88893352
105MP0002229_neurodegeneration0.87997616
106MP0004133_heterotaxia0.87922397
107MP0005332_abnormal_amino_acid0.87852021
108MP0000313_abnormal_cell_death0.87774913
109MP0002090_abnormal_vision0.85967716
110MP0003941_abnormal_skin_development0.85568913
111MP0002752_abnormal_somatic_nervous0.84990714
112MP0001764_abnormal_homeostasis0.84630726
113MP0001963_abnormal_hearing_physiology0.83366542
114MP0002751_abnormal_autonomic_nervous0.83195695
115MP0003890_abnormal_embryonic-extraembry0.82816335
116MP0001672_abnormal_embryogenesis/_devel0.81738531
117MP0005380_embryogenesis_phenotype0.81738531
118MP0002160_abnormal_reproductive_system0.80910433
119MP0002332_abnormal_exercise_endurance0.79790846
120MP0000751_myopathy0.79624239
121MP0000631_abnormal_neuroendocrine_gland0.78682395
122MP0008875_abnormal_xenobiotic_pharmacok0.78425446
123MP0001324_abnormal_eye_pigmentation0.78068868
124MP0003950_abnormal_plasma_membrane0.77540468
125MP0003315_abnormal_perineum_morphology0.77528432
126MP0005391_vision/eye_phenotype0.76167953
127MP0002080_prenatal_lethality0.76090795
128MP0003121_genomic_imprinting0.75879769
129MP0002085_abnormal_embryonic_tissue0.74709224
130MP0002084_abnormal_developmental_patter0.73461606
131MP0005636_abnormal_mineral_homeostasis0.73103539
132MP0004811_abnormal_neuron_physiology0.73074587
133MP0000647_abnormal_sebaceous_gland0.72940479
134MP0002938_white_spotting0.72588003
135MP0001664_abnormal_digestion0.72537734
136MP0002928_abnormal_bile_duct0.72521162
137MP0005266_abnormal_metabolism0.72013200
138MP0001542_abnormal_bone_strength0.71754372
139MP0005171_absent_coat_pigmentation0.69977111
140MP0002233_abnormal_nose_morphology0.69869117
141MP0005395_other_phenotype0.69220129
142MP0003119_abnormal_digestive_system0.68944466
143MP0002132_abnormal_respiratory_system0.68882648
144MP0000372_irregular_coat_pigmentation0.68829878
145MP0001119_abnormal_female_reproductive0.68235284
146MP0002163_abnormal_gland_morphology0.68047496
147MP0002653_abnormal_ependyma_morphology0.67443992
148MP0000026_abnormal_inner_ear0.67171171
149MP0006072_abnormal_retinal_apoptosis0.66773893
150MP0000516_abnormal_urinary_system0.66373039
151MP0005620_abnormal_muscle_contractility0.65944404
152MP0008932_abnormal_embryonic_tissue0.64889163
153MP0003718_maternal_effect0.64703846
154MP0003136_yellow_coat_color0.64229923
155MP0002152_abnormal_brain_morphology0.63417374
156MP0002102_abnormal_ear_morphology0.61576459
157MP0005253_abnormal_eye_physiology0.60730811
158MP0002069_abnormal_eating/drinking_beha0.60369159

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.69818105
2Abnormal mitochondria in muscle tissue (HP:0008316)6.19060047
3Mitochondrial inheritance (HP:0001427)5.98695814
4Progressive macrocephaly (HP:0004481)5.79670300
5Acute encephalopathy (HP:0006846)5.65698754
6Increased CSF lactate (HP:0002490)5.25573162
7Hepatocellular necrosis (HP:0001404)5.10489759
8Abnormality of glycolysis (HP:0004366)4.78368207
9Increased serum pyruvate (HP:0003542)4.78368207
10Increased hepatocellular lipid droplets (HP:0006565)4.70477222
11Hepatic necrosis (HP:0002605)4.49543007
12Lipid accumulation in hepatocytes (HP:0006561)4.26740728
13Cerebral edema (HP:0002181)4.16728428
143-Methylglutaconic aciduria (HP:0003535)3.82423202
15Lactic acidosis (HP:0003128)3.80583365
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.80200533
17Neuroendocrine neoplasm (HP:0100634)3.73093146
18Focal motor seizures (HP:0011153)3.71977798
19Renal Fanconi syndrome (HP:0001994)3.66657642
20Increased serum lactate (HP:0002151)3.66418758
21Pheochromocytoma (HP:0002666)3.63590383
22Respiratory failure (HP:0002878)3.50974074
23Optic disc pallor (HP:0000543)3.50750477
24Exercise intolerance (HP:0003546)3.44819509
25Increased intramyocellular lipid droplets (HP:0012240)3.42651546
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.37552089
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.37095866
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.37095866
29Abnormality of alanine metabolism (HP:0010916)3.34295176
30Hyperalaninemia (HP:0003348)3.34295176
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.34295176
32Leukodystrophy (HP:0002415)3.33367747
33Atonic seizures (HP:0010819)3.32723813
34Hyperventilation (HP:0002883)3.18551913
35Reticulocytopenia (HP:0001896)3.18137599
36Myokymia (HP:0002411)2.93309719
37Microvesicular hepatic steatosis (HP:0001414)2.90753185
38Increased muscle lipid content (HP:0009058)2.86668397
39Epileptic encephalopathy (HP:0200134)2.85742866
40Respiratory difficulties (HP:0002880)2.78494851
41Abnormal hair whorl (HP:0010721)2.77140480
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73855068
43Chromsome breakage (HP:0040012)2.71232535
44Exertional dyspnea (HP:0002875)2.70288236
45X-linked dominant inheritance (HP:0001423)2.63878575
46Hyperglycinemia (HP:0002154)2.63212030
47Meckel diverticulum (HP:0002245)2.60997973
48Hypothermia (HP:0002045)2.54482936
49Abnormality of the ileum (HP:0001549)2.51927505
50Type I transferrin isoform profile (HP:0003642)2.49132971
51Febrile seizures (HP:0002373)2.47522929
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.43076506
53Gait imbalance (HP:0002141)2.42976351
54Abnormality of the preputium (HP:0100587)2.37903294
55Abnormality of renal resorption (HP:0011038)2.37892926
56CNS demyelination (HP:0007305)2.35979990
57Abnormality of methionine metabolism (HP:0010901)2.34659998
58Pancreatic cysts (HP:0001737)2.33204903
59Medial flaring of the eyebrow (HP:0010747)2.33164947
60Congenital primary aphakia (HP:0007707)2.31593277
61Cerebral hypomyelination (HP:0006808)2.31501411
62Abnormality of serum amino acid levels (HP:0003112)2.29006153
63Abnormality of chromosome stability (HP:0003220)2.27483081
64Emotional lability (HP:0000712)2.27437882
65Pancreatic fibrosis (HP:0100732)2.26658366
66Nephrogenic diabetes insipidus (HP:0009806)2.25597645
67Lethargy (HP:0001254)2.25051008
68Colon cancer (HP:0003003)2.21502264
69Absence seizures (HP:0002121)2.17753839
70Pancytopenia (HP:0001876)2.17079660
71Abnormality of the anterior horn cell (HP:0006802)2.14884992
72Degeneration of anterior horn cells (HP:0002398)2.14884992
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12672883
74Molar tooth sign on MRI (HP:0002419)2.10968113
75Abnormality of midbrain morphology (HP:0002418)2.10968113
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08465529
77Abnormal protein N-linked glycosylation (HP:0012347)2.08465529
78Abnormal protein glycosylation (HP:0012346)2.08465529
79Abnormal glycosylation (HP:0012345)2.08465529
80Pallor (HP:0000980)2.07920140
81Focal seizures (HP:0007359)2.06214345
82Generalized tonic-clonic seizures (HP:0002069)1.99940186
83True hermaphroditism (HP:0010459)1.97763777
84Dialeptic seizures (HP:0011146)1.97409509
85Methylmalonic acidemia (HP:0002912)1.96824807
86Duodenal stenosis (HP:0100867)1.94889262
87Small intestinal stenosis (HP:0012848)1.94889262
88Reduced antithrombin III activity (HP:0001976)1.93565125
89Neoplasm of the peripheral nervous system (HP:0100007)1.92878229
90Sensory axonal neuropathy (HP:0003390)1.92737259
91Dicarboxylic aciduria (HP:0003215)1.92254487
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92254487
93Broad-based gait (HP:0002136)1.92023314
94Abnormality of cells of the erythroid lineage (HP:0012130)1.91958077
95Anxiety (HP:0000739)1.91936710
96Triphalangeal thumb (HP:0001199)1.91697198
97Autoamputation (HP:0001218)1.91538635
98Oral leukoplakia (HP:0002745)1.91114010
99Ragged-red muscle fibers (HP:0003200)1.91033053
100Genital tract atresia (HP:0001827)1.90883280
101Hypoglycemic coma (HP:0001325)1.90866445
102Limb dystonia (HP:0002451)1.90437564
103Generalized aminoaciduria (HP:0002909)1.90195972
104Congenital, generalized hypertrichosis (HP:0004540)1.89680964
105Degeneration of the lateral corticospinal tracts (HP:0002314)1.88791734
106Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88791734
107Vaginal atresia (HP:0000148)1.88502329
108Poor suck (HP:0002033)1.86986337
109Glycosuria (HP:0003076)1.82881688
110Abnormality of urine glucose concentration (HP:0011016)1.82881688
111Progressive inability to walk (HP:0002505)1.80559462
112Megaloblastic anemia (HP:0001889)1.80295916
113Absent thumb (HP:0009777)1.80056196
114Poor coordination (HP:0002370)1.80049339
115Methylmalonic aciduria (HP:0012120)1.79712937
116Abnormal lung lobation (HP:0002101)1.79284175
117Macrocytic anemia (HP:0001972)1.78897500
118Delayed CNS myelination (HP:0002188)1.78370276
119Abnormality of the duodenum (HP:0002246)1.77821839
120Cerebral hemorrhage (HP:0001342)1.77619266
121Gliosis (HP:0002171)1.76880238
122Unsteady gait (HP:0002317)1.76247588
123Hypoplastic left heart (HP:0004383)1.76188711
124Abnormality of serine family amino acid metabolism (HP:0010894)1.75826673
125Abnormality of glycine metabolism (HP:0010895)1.75826673
126Muscle hypertrophy of the lower extremities (HP:0008968)1.73820965
127Bile duct proliferation (HP:0001408)1.72573717
128Abnormal biliary tract physiology (HP:0012439)1.72573717
129Horseshoe kidney (HP:0000085)1.72358731
130Abnormal number of erythroid precursors (HP:0012131)1.70936839
131Delusions (HP:0000746)1.70808576
132Birth length less than 3rd percentile (HP:0003561)1.70645564
133Aplastic anemia (HP:0001915)1.70290114
134Breast hypoplasia (HP:0003187)1.70197616
135Myotonia (HP:0002486)1.70030051
136CNS hypomyelination (HP:0003429)1.69727454
137Hyperphosphaturia (HP:0003109)1.68015768
138Abnormal gallbladder physiology (HP:0012438)1.67820950
139Cholecystitis (HP:0001082)1.67820950
140Renal tubular dysfunction (HP:0000124)1.66337336
141Conjunctival hamartoma (HP:0100780)1.66069242
142Inability to walk (HP:0002540)1.65775941
143Progressive cerebellar ataxia (HP:0002073)1.64479316
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64243020
145Palpitations (HP:0001962)1.63107241
146Delayed gross motor development (HP:0002194)1.62496239
147Blindness (HP:0000618)1.61818647
148Abnormality of the labia minora (HP:0012880)1.60524860
149Female pseudohermaphroditism (HP:0010458)1.59459709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.72165141
2VRK24.01644585
3MAP2K73.45947400
4MAP3K123.44871793
5CDC72.90137183
6MAP3K42.82730172
7STK162.77338761
8ARAF2.65488938
9NME12.60245492
10TTK2.16990886
11NUAK12.14221905
12MAP4K22.11464077
13BCR2.09448353
14PLK42.08310576
15CDK191.96988954
16TRIM281.85508153
17NTRK31.83055392
18BUB11.80698555
19OXSR11.68830534
20MAP2K41.64331553
21EIF2AK11.63414439
22TSSK61.63242435
23WNK31.60591987
24STK391.55031054
25PLK21.51908973
26MUSK1.50365551
27NME21.49832006
28BRAF1.49124949
29SIK31.46939593
30VRK11.46329652
31LIMK11.45413874
32EPHA41.44120917
33ACVR1B1.40847342
34PLK11.39172858
35MYLK1.39103816
36PASK1.35752314
37BMPR1B1.34362985
38CDK81.33029801
39MINK11.31726902
40AKT31.30882994
41MKNK11.28974804
42MAPK131.27732166
43GRK51.27461212
44BCKDK1.26993489
45CSNK1G31.22306699
46CCNB11.21902836
47TNIK1.16807091
48PNCK1.12234421
49MKNK21.11536342
50TAF11.09586931
51EIF2AK31.09014209
52ATR1.06223943
53OBSCN1.05646293
54PDK21.05103311
55GRK11.04738685
56ADRBK21.01909569
57MAP3K90.98610207
58AURKB0.97722745
59MST40.96946995
60MARK10.96826985
61PDK40.93907447
62PDK30.93907447
63TNK20.93556542
64CSNK1G20.92279408
65DYRK30.91957822
66DAPK10.89389169
67CAMK2B0.88940542
68WEE10.88913399
69CAMK2A0.87770796
70CHEK20.87483063
71MAPKAPK50.86980567
72UHMK10.85283394
73GRK70.80783032
74PLK30.80540393
75BRSK10.77342800
76BMPR20.75774502
77DYRK20.74913334
78CSNK2A20.73579071
79INSRR0.72945827
80PBK0.71694633
81SRPK10.70238598
82CSNK1G10.69991275
83ADRBK10.69499902
84CSNK2A10.68477357
85ERBB40.68150114
86TIE10.67719829
87STK40.66664372
88EIF2AK20.66467072
89NEK20.65986813
90RPS6KA50.65984074
91ATM0.65346925
92CDK70.64528680
93KSR10.63829076
94CAMK2D0.61422650
95CDK180.60835501
96CSNK1A1L0.60103271
97PRKCG0.59531693
98PRPF4B0.58783258
99CAMKK20.58169165
100PIK3CA0.57954755
101SGK2230.57210773
102SGK4940.57210773
103SCYL20.56885803
104CDK140.56727317
105CHEK10.56227750
106CDK50.55194816
107MAP3K60.54703644
108AURKA0.53881076
109FRK0.53324223
110RPS6KA40.52619183
111ERBB30.52565004
112NEK10.52333793
113WNK40.51653110
114TLK10.50408429
115CAMK2G0.50405896
116PRKCE0.50020861
117KDR0.49408611
118YES10.48964902
119NEK60.48485354
120CDK30.48405933
121RAF10.48219042
122SGK20.48138075
123CDK150.48028430
124TEC0.46504268
125PHKG10.44775897
126PHKG20.44775897
127PIM20.44556713
128CDK11A0.43925746
129CLK10.43821066
130PINK10.43372049
131BRSK20.42177035
132ZAK0.41944685
133PRKACA0.41599112
134DYRK1A0.41551368
135TESK20.41039239
136STK30.40878718
137ABL20.40110071
138STK38L0.37121362
139CSNK1E0.35712318
140PAK40.31641301
141MAP3K80.29969890
142CDK10.29903852
143FLT30.29592296
144CSNK1A10.27364355
145CDK20.26551964
146ILK0.25357028
147ALK0.25324062
148LRRK20.24648496
149PRKDC0.24592944

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.70736371
2Parkinsons disease_Homo sapiens_hsa050124.96770725
3Alzheimers disease_Homo sapiens_hsa050103.74551668
4Huntingtons disease_Homo sapiens_hsa050163.52059826
5Proteasome_Homo sapiens_hsa030503.25957394
6Ribosome_Homo sapiens_hsa030103.24086182
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.81183872
8RNA polymerase_Homo sapiens_hsa030202.59766063
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.50732253
10Cardiac muscle contraction_Homo sapiens_hsa042602.39449503
11Protein export_Homo sapiens_hsa030602.26529118
12Nicotine addiction_Homo sapiens_hsa050332.26475892
13Collecting duct acid secretion_Homo sapiens_hsa049662.19809628
14One carbon pool by folate_Homo sapiens_hsa006701.99366429
15Synaptic vesicle cycle_Homo sapiens_hsa047211.95632907
16Fanconi anemia pathway_Homo sapiens_hsa034601.87849958
17Vibrio cholerae infection_Homo sapiens_hsa051101.74745219
18Fatty acid elongation_Homo sapiens_hsa000621.71827264
19Pyruvate metabolism_Homo sapiens_hsa006201.58787289
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57563666
21Propanoate metabolism_Homo sapiens_hsa006401.57117744
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54664095
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46831264
24Folate biosynthesis_Homo sapiens_hsa007901.44711710
25Sulfur metabolism_Homo sapiens_hsa009201.40231191
26Pyrimidine metabolism_Homo sapiens_hsa002401.29388398
27Cell cycle_Homo sapiens_hsa041101.20750404
28GABAergic synapse_Homo sapiens_hsa047271.20400116
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17438511
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16943384
31Serotonergic synapse_Homo sapiens_hsa047261.14485557
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14272472
33Taste transduction_Homo sapiens_hsa047421.11078995
34Purine metabolism_Homo sapiens_hsa002301.00988044
35Phototransduction_Homo sapiens_hsa047441.00200127
36Vitamin B6 metabolism_Homo sapiens_hsa007500.99079513
37Morphine addiction_Homo sapiens_hsa050320.98206031
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98014713
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.97563958
40Dopaminergic synapse_Homo sapiens_hsa047280.96714835
41Basal transcription factors_Homo sapiens_hsa030220.95413683
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95117278
43Amphetamine addiction_Homo sapiens_hsa050310.94273888
44Nucleotide excision repair_Homo sapiens_hsa034200.94118013
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89678083
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86570200
47Metabolic pathways_Homo sapiens_hsa011000.86125863
48Olfactory transduction_Homo sapiens_hsa047400.85349505
49Carbon metabolism_Homo sapiens_hsa012000.84700250
50Circadian entrainment_Homo sapiens_hsa047130.83739427
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82468719
52Steroid biosynthesis_Homo sapiens_hsa001000.82047433
53Sulfur relay system_Homo sapiens_hsa041220.81452242
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78214807
55Glutamatergic synapse_Homo sapiens_hsa047240.76386981
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76089366
57Spliceosome_Homo sapiens_hsa030400.75936363
58Butanoate metabolism_Homo sapiens_hsa006500.74982603
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74876891
60RNA degradation_Homo sapiens_hsa030180.74725877
61Long-term potentiation_Homo sapiens_hsa047200.72915470
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70208228
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.68887939
64mRNA surveillance pathway_Homo sapiens_hsa030150.63853451
65Homologous recombination_Homo sapiens_hsa034400.63738500
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63342223
67Mismatch repair_Homo sapiens_hsa034300.62387335
68Selenocompound metabolism_Homo sapiens_hsa004500.62080555
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60213017
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.58530787
71Peroxisome_Homo sapiens_hsa041460.58523914
72Fatty acid metabolism_Homo sapiens_hsa012120.57830546
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57250515
74Calcium signaling pathway_Homo sapiens_hsa040200.57005734
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.56826819
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56003921
77Cocaine addiction_Homo sapiens_hsa050300.54616444
78Nitrogen metabolism_Homo sapiens_hsa009100.51840154
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51222872
80Phenylalanine metabolism_Homo sapiens_hsa003600.51013185
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50994351
82Fatty acid degradation_Homo sapiens_hsa000710.49359240
83Tyrosine metabolism_Homo sapiens_hsa003500.49216199
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47014378
85Chemical carcinogenesis_Homo sapiens_hsa052040.46121438
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46112251
87N-Glycan biosynthesis_Homo sapiens_hsa005100.44994942
88Oocyte meiosis_Homo sapiens_hsa041140.44799995
89DNA replication_Homo sapiens_hsa030300.44203365
90Salivary secretion_Homo sapiens_hsa049700.43778713
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43611727
92Caffeine metabolism_Homo sapiens_hsa002320.43440819
93Rheumatoid arthritis_Homo sapiens_hsa053230.42780118
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42499127
95p53 signaling pathway_Homo sapiens_hsa041150.41773131
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41722266
97Long-term depression_Homo sapiens_hsa047300.41634133
98RNA transport_Homo sapiens_hsa030130.41348827
99Retinol metabolism_Homo sapiens_hsa008300.39681809
100Cholinergic synapse_Homo sapiens_hsa047250.39540154
101Tryptophan metabolism_Homo sapiens_hsa003800.38698959
102Glutathione metabolism_Homo sapiens_hsa004800.37570522
103Pentose phosphate pathway_Homo sapiens_hsa000300.35449601
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34882408
105Regulation of autophagy_Homo sapiens_hsa041400.34314715
106Systemic lupus erythematosus_Homo sapiens_hsa053220.33860851
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33070063
108Biosynthesis of amino acids_Homo sapiens_hsa012300.31014627
109Non-homologous end-joining_Homo sapiens_hsa034500.29365682
110Renin secretion_Homo sapiens_hsa049240.28946497
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.27802255
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27353009
113Ether lipid metabolism_Homo sapiens_hsa005650.27318913
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27191738
115Alcoholism_Homo sapiens_hsa050340.26733782
116beta-Alanine metabolism_Homo sapiens_hsa004100.26452614
117Insulin secretion_Homo sapiens_hsa049110.26280070
118Arginine and proline metabolism_Homo sapiens_hsa003300.24586376
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23828815
120Epstein-Barr virus infection_Homo sapiens_hsa051690.22017515
121Histidine metabolism_Homo sapiens_hsa003400.21217616
122Oxytocin signaling pathway_Homo sapiens_hsa049210.20776026
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20508401
124Vitamin digestion and absorption_Homo sapiens_hsa049770.20099645
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20097991
126Fructose and mannose metabolism_Homo sapiens_hsa000510.18692683
127Phagosome_Homo sapiens_hsa041450.17933052
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.17293274
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17219710
130Base excision repair_Homo sapiens_hsa034100.17194012
131Arginine biosynthesis_Homo sapiens_hsa002200.17090800
132Starch and sucrose metabolism_Homo sapiens_hsa005000.17035609
133Arachidonic acid metabolism_Homo sapiens_hsa005900.16654309
134Gastric acid secretion_Homo sapiens_hsa049710.16551128
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15215696

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