

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.53048923 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 7.08557424 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 7.08557424 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 6.96854158 |
| 5 | respiratory electron transport chain (GO:0022904) | 6.26104525 |
| 6 | electron transport chain (GO:0022900) | 6.11234952 |
| 7 | chaperone-mediated protein transport (GO:0072321) | 5.39620312 |
| 8 | protein complex biogenesis (GO:0070271) | 5.37816242 |
| 9 | mitochondrial respiratory chain complex assembly (GO:0033108) | 5.04314115 |
| 10 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.96346182 |
| 11 | NADH dehydrogenase complex assembly (GO:0010257) | 4.96346182 |
| 12 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.96346182 |
| 13 | regulation of mitochondrial translation (GO:0070129) | 4.57310146 |
| 14 | protein-cofactor linkage (GO:0018065) | 4.28947441 |
| 15 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.28642338 |
| 16 | protein neddylation (GO:0045116) | 4.27934090 |
| 17 | cullin deneddylation (GO:0010388) | 4.18809206 |
| 18 | inner mitochondrial membrane organization (GO:0007007) | 4.04425899 |
| 19 | ribosomal large subunit biogenesis (GO:0042273) | 3.92591077 |
| 20 | oxidative phosphorylation (GO:0006119) | 3.90209445 |
| 21 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.87566212 |
| 22 | chromatin remodeling at centromere (GO:0031055) | 3.84745712 |
| 23 | CENP-A containing nucleosome assembly (GO:0034080) | 3.83228749 |
| 24 | neuron cell-cell adhesion (GO:0007158) | 3.79793155 |
| 25 | establishment of integrated proviral latency (GO:0075713) | 3.78489078 |
| 26 | respiratory chain complex IV assembly (GO:0008535) | 3.76612834 |
| 27 | positive regulation of mitochondrial fission (GO:0090141) | 3.75372151 |
| 28 | ATP biosynthetic process (GO:0006754) | 3.74956863 |
| 29 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.74802358 |
| 30 | GTP biosynthetic process (GO:0006183) | 3.74261592 |
| 31 | protein deneddylation (GO:0000338) | 3.73993240 |
| 32 | hydrogen ion transmembrane transport (GO:1902600) | 3.73247833 |
| 33 | DNA replication checkpoint (GO:0000076) | 3.72089815 |
| 34 | dopamine transport (GO:0015872) | 3.71615166 |
| 35 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.71504580 |
| 36 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.69648989 |
| 37 | cytochrome complex assembly (GO:0017004) | 3.68567691 |
| 38 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.66644687 |
| 39 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.64618394 |
| 40 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.64590969 |
| 41 | presynaptic membrane assembly (GO:0097105) | 3.61348047 |
| 42 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.60074668 |
| 43 | protein targeting to mitochondrion (GO:0006626) | 3.59257333 |
| 44 | pseudouridine synthesis (GO:0001522) | 3.57500569 |
| 45 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.51515155 |
| 46 | ribosomal small subunit biogenesis (GO:0042274) | 3.51382045 |
| 47 | purine nucleobase biosynthetic process (GO:0009113) | 3.48886826 |
| 48 | establishment of protein localization to mitochondrion (GO:0072655) | 3.45521394 |
| 49 | translation (GO:0006412) | 3.44449205 |
| 50 | quinone biosynthetic process (GO:1901663) | 3.42814957 |
| 51 | ubiquinone biosynthetic process (GO:0006744) | 3.42814957 |
| 52 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.42738554 |
| 53 | spliceosomal snRNP assembly (GO:0000387) | 3.38303518 |
| 54 | maturation of 5.8S rRNA (GO:0000460) | 3.38208049 |
| 55 | proton transport (GO:0015992) | 3.36991439 |
| 56 | rRNA methylation (GO:0031167) | 3.35985844 |
| 57 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.35032458 |
| 58 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.34598533 |
| 59 | presynaptic membrane organization (GO:0097090) | 3.33992902 |
| 60 | DNA double-strand break processing (GO:0000729) | 3.33900528 |
| 61 | DNA strand elongation (GO:0022616) | 3.33235148 |
| 62 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.32765252 |
| 63 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.32765252 |
| 64 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.32765252 |
| 65 | protein localization to mitochondrion (GO:0070585) | 3.31132022 |
| 66 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.31096014 |
| 67 | hydrogen transport (GO:0006818) | 3.29458608 |
| 68 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.29360942 |
| 69 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.29360942 |
| 70 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.27294873 |
| 71 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.26757295 |
| 72 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.26757295 |
| 73 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.25649234 |
| 74 | termination of RNA polymerase III transcription (GO:0006386) | 3.25649234 |
| 75 | nucleobase biosynthetic process (GO:0046112) | 3.24632418 |
| 76 | ribosomal small subunit assembly (GO:0000028) | 3.24565043 |
| 77 | mitochondrial fragmentation involved in apoptotic process (GO:0043653) | 3.23797458 |
| 78 | translational initiation (GO:0006413) | 3.23238660 |
| 79 | translational elongation (GO:0006414) | 3.22887358 |
| 80 | IMP biosynthetic process (GO:0006188) | 3.22328797 |
| 81 | positive regulation of ligase activity (GO:0051351) | 3.21838899 |
| 82 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.21616933 |
| 83 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.21616933 |
| 84 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.20604578 |
| 85 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.19315365 |
| 86 | proteasome assembly (GO:0043248) | 3.19102813 |
| 87 | ubiquinone metabolic process (GO:0006743) | 3.18528582 |
| 88 | rRNA processing (GO:0006364) | 3.18120831 |
| 89 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.16941633 |
| 90 | aerobic respiration (GO:0009060) | 3.15967537 |
| 91 | succinate metabolic process (GO:0006105) | 3.14121664 |
| 92 | histone exchange (GO:0043486) | 3.13821269 |
| 93 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.13297906 |
| 94 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.13297906 |
| 95 | telomere maintenance via recombination (GO:0000722) | 3.13194316 |
| 96 | transcription from mitochondrial promoter (GO:0006390) | 3.12498275 |
| 97 | protein localization to synapse (GO:0035418) | 3.12256228 |
| 98 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.11407100 |
| 99 | establishment of viral latency (GO:0019043) | 3.11240674 |
| 100 | histone mRNA metabolic process (GO:0008334) | 3.10587600 |
| 101 | regulation of helicase activity (GO:0051095) | 3.07467987 |
| 102 | NADH metabolic process (GO:0006734) | 3.07305826 |
| 103 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.06362984 |
| 104 | 7-methylguanosine mRNA capping (GO:0006370) | 3.06045390 |
| 105 | ribosome assembly (GO:0042255) | 3.05313767 |
| 106 | rRNA metabolic process (GO:0016072) | 3.05182043 |
| 107 | UTP biosynthetic process (GO:0006228) | 3.04899802 |
| 108 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.04076298 |
| 109 | mitotic metaphase plate congression (GO:0007080) | 3.03461289 |
| 110 | 7-methylguanosine RNA capping (GO:0009452) | 3.03373853 |
| 111 | RNA capping (GO:0036260) | 3.03373853 |
| 112 | DNA damage response, detection of DNA damage (GO:0042769) | 3.02697129 |
| 113 | peptidyl-histidine modification (GO:0018202) | 3.01761076 |
| 114 | mitotic recombination (GO:0006312) | 3.01532319 |
| 115 | L-methionine salvage (GO:0071267) | 2.99788492 |
| 116 | L-methionine biosynthetic process (GO:0071265) | 2.99788492 |
| 117 | amino acid salvage (GO:0043102) | 2.99788492 |
| 118 | neurotransmitter uptake (GO:0001504) | 2.99506517 |
| 119 | tricarboxylic acid cycle (GO:0006099) | 2.97377826 |
| 120 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.97065011 |
| 121 | mitochondrial transport (GO:0006839) | 2.95148461 |
| 122 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 2.94507622 |
| 123 | synaptic vesicle exocytosis (GO:0016079) | 2.91193409 |
| 124 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.87049472 |
| 125 | neuronal action potential propagation (GO:0019227) | 2.84328608 |
| 126 | startle response (GO:0001964) | 2.83326607 |
| 127 | positive regulation of synapse assembly (GO:0051965) | 2.81703104 |
| 128 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.80557568 |
| 129 | cellular respiration (GO:0045333) | 2.79439167 |
| 130 | quinone metabolic process (GO:1901661) | 2.78552757 |
| 131 | maturation of SSU-rRNA (GO:0030490) | 2.77001964 |
| 132 | viral transcription (GO:0019083) | 2.76050202 |
| 133 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.74340906 |
| 134 | translational termination (GO:0006415) | 2.73875256 |
| 135 | UTP metabolic process (GO:0046051) | 2.73151069 |
| 136 | CTP metabolic process (GO:0046036) | 2.72859186 |
| 137 | CTP biosynthetic process (GO:0006241) | 2.72859186 |
| 138 | regulation of cofactor metabolic process (GO:0051193) | 2.71681761 |
| 139 | regulation of coenzyme metabolic process (GO:0051196) | 2.71681761 |
| 140 | vocalization behavior (GO:0071625) | 2.71378443 |
| 141 | cotranslational protein targeting to membrane (GO:0006613) | 2.71269428 |
| 142 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.69392624 |
| 143 | rRNA modification (GO:0000154) | 2.66777659 |
| 144 | intracellular protein transmembrane import (GO:0044743) | 2.64857926 |
| 145 | cellular component biogenesis (GO:0044085) | 2.64564699 |
| 146 | protein localization to endoplasmic reticulum (GO:0070972) | 2.63766668 |
| 147 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.63422078 |
| 148 | regulation of mitochondrial fission (GO:0090140) | 2.62971011 |
| 149 | regulation of cellular respiration (GO:0043457) | 2.60713913 |
| 150 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.60312478 |
| 151 | negative regulation of ligase activity (GO:0051352) | 2.60009559 |
| 152 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.60009559 |
| 153 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.59257604 |
| 154 | protein targeting to ER (GO:0045047) | 2.58785820 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.78662628 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.24401119 |
| 3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.70952934 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.37996987 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.35971605 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.34648258 |
| 7 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.31994228 |
| 8 | TAF15_26573619_Chip-Seq_HEK293_Human | 3.23832411 |
| 9 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.13311867 |
| 10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.11462616 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.03793202 |
| 12 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.69974244 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.69326685 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.68445394 |
| 15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.63474607 |
| 16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.37964652 |
| 17 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.37607802 |
| 18 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.35862754 |
| 19 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.27938775 |
| 20 | FUS_26573619_Chip-Seq_HEK293_Human | 2.23738573 |
| 21 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.14579604 |
| 22 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.14311585 |
| 23 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.13366918 |
| 24 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.99981700 |
| 25 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.98029613 |
| 26 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.93298638 |
| 27 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.90879563 |
| 28 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.90268574 |
| 29 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.86137425 |
| 30 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.85965830 |
| 31 | VDR_22108803_ChIP-Seq_LS180_Human | 1.85221088 |
| 32 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.75407934 |
| 33 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.72729330 |
| 34 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.70709493 |
| 35 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.66323761 |
| 36 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.66219442 |
| 37 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.59779720 |
| 38 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.58978361 |
| 39 | EWS_26573619_Chip-Seq_HEK293_Human | 1.56958338 |
| 40 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.55754063 |
| 41 | P300_19829295_ChIP-Seq_ESCs_Human | 1.54933981 |
| 42 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.54758744 |
| 43 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.54410394 |
| 44 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.54346406 |
| 45 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.54029667 |
| 46 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.52952261 |
| 47 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.51192815 |
| 48 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.50715961 |
| 49 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.49201114 |
| 50 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.48929735 |
| 51 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.47244402 |
| 52 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.45835686 |
| 53 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.45111632 |
| 54 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.43749776 |
| 55 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.43278984 |
| 56 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.41672656 |
| 57 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.41456527 |
| 58 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.39565036 |
| 59 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.38984410 |
| 60 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.36781421 |
| 61 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.36055072 |
| 62 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.35869142 |
| 63 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.34101221 |
| 64 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.32799574 |
| 65 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.29716204 |
| 66 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.29692374 |
| 67 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.28714510 |
| 68 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.26254711 |
| 69 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.26028300 |
| 70 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.25521320 |
| 71 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.25464004 |
| 72 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.25092181 |
| 73 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.25021806 |
| 74 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.24971700 |
| 75 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.24214793 |
| 76 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.21076683 |
| 77 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.20345125 |
| 78 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.18082058 |
| 79 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.17741400 |
| 80 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.16994583 |
| 81 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.16543788 |
| 82 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.13926799 |
| 83 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.13685378 |
| 84 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.13509591 |
| 85 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.13357010 |
| 86 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.13333637 |
| 87 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.12539964 |
| 88 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.12484254 |
| 89 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.12179309 |
| 90 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.11640367 |
| 91 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.11170901 |
| 92 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.11155472 |
| 93 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.10888352 |
| 94 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.09297653 |
| 95 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.08914788 |
| 96 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.07273464 |
| 97 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.06208693 |
| 98 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.06198191 |
| 99 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.06166220 |
| 100 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.06059283 |
| 101 | JUN_21703547_ChIP-Seq_K562_Human | 1.06028670 |
| 102 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.05603454 |
| 103 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.03352594 |
| 104 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.01612075 |
| 105 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.00937667 |
| 106 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.00495448 |
| 107 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.99741790 |
| 108 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.98975317 |
| 109 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97658700 |
| 110 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.97650807 |
| 111 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.95858302 |
| 112 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95487585 |
| 113 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.94590708 |
| 114 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.94373690 |
| 115 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.94024414 |
| 116 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.93902770 |
| 117 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.93545483 |
| 118 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 0.92906470 |
| 119 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.91977737 |
| 120 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.91734251 |
| 121 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.91337830 |
| 122 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.90547455 |
| 123 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.90181256 |
| 124 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.89905195 |
| 125 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 0.89838840 |
| 126 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.89821499 |
| 127 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.89241515 |
| 128 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.87830446 |
| 129 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.87480311 |
| 130 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.86915889 |
| 131 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.86710998 |
| 132 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.86167634 |
| 133 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.81058388 |
| 134 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.80413156 |
| 135 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.78265428 |
| 136 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.77042335 |
| 137 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.77040938 |
| 138 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.72236765 |
| 139 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.71921958 |
| 140 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.67568224 |
| 141 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.65774840 |
| 142 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.64371070 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 5.33553145 |
| 2 | MP0008058_abnormal_DNA_repair | 4.60600404 |
| 3 | MP0009379_abnormal_foot_pigmentation | 4.03293204 |
| 4 | MP0010094_abnormal_chromosome_stability | 3.85847164 |
| 5 | MP0003693_abnormal_embryo_hatching | 3.63903532 |
| 6 | MP0001529_abnormal_vocalization | 3.56698884 |
| 7 | MP0006276_abnormal_autonomic_nervous | 3.42143116 |
| 8 | MP0004957_abnormal_blastocyst_morpholog | 3.38169972 |
| 9 | MP0003111_abnormal_nucleus_morphology | 2.80461879 |
| 10 | MP0009046_muscle_twitch | 2.68982732 |
| 11 | MP0006292_abnormal_olfactory_placode | 2.66858948 |
| 12 | MP0003077_abnormal_cell_cycle | 2.63817647 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.60161300 |
| 14 | MP0002736_abnormal_nociception_after | 2.57495792 |
| 15 | MP0003186_abnormal_redox_activity | 2.49085105 |
| 16 | MP0004859_abnormal_synaptic_plasticity | 2.44521700 |
| 17 | MP0009745_abnormal_behavioral_response | 2.42366620 |
| 18 | MP0001188_hyperpigmentation | 2.41791544 |
| 19 | MP0004270_analgesia | 2.40247605 |
| 20 | MP0003635_abnormal_synaptic_transmissio | 2.38996980 |
| 21 | MP0002272_abnormal_nervous_system | 2.32471416 |
| 22 | MP0001905_abnormal_dopamine_level | 2.31785340 |
| 23 | MP0002064_seizures | 2.28479940 |
| 24 | MP0006035_abnormal_mitochondrial_morpho | 2.20421277 |
| 25 | MP0003786_premature_aging | 2.17450827 |
| 26 | MP0008007_abnormal_cellular_replicative | 2.07500455 |
| 27 | MP0005423_abnormal_somatic_nervous | 2.05814598 |
| 28 | MP0002572_abnormal_emotion/affect_behav | 2.05633197 |
| 29 | MP0004142_abnormal_muscle_tone | 2.01033605 |
| 30 | MP0006036_abnormal_mitochondrial_physio | 2.00907137 |
| 31 | MP0008057_abnormal_DNA_replication | 1.96015652 |
| 32 | MP0002734_abnormal_mechanical_nocicepti | 1.93980830 |
| 33 | MP0002063_abnormal_learning/memory/cond | 1.93665619 |
| 34 | MP0002735_abnormal_chemical_nociception | 1.93119953 |
| 35 | MP0002837_dystrophic_cardiac_calcinosis | 1.93079690 |
| 36 | MP0009697_abnormal_copulation | 1.91714290 |
| 37 | MP0005646_abnormal_pituitary_gland | 1.88912748 |
| 38 | MP0001984_abnormal_olfaction | 1.88716422 |
| 39 | MP0001486_abnormal_startle_reflex | 1.86679099 |
| 40 | MP0002067_abnormal_sensory_capabilities | 1.78747993 |
| 41 | MP0001986_abnormal_taste_sensitivity | 1.78325965 |
| 42 | MP0001293_anophthalmia | 1.75004180 |
| 43 | MP0008995_early_reproductive_senescence | 1.71905332 |
| 44 | MP0001501_abnormal_sleep_pattern | 1.71561418 |
| 45 | MP0003122_maternal_imprinting | 1.68731401 |
| 46 | MP0001440_abnormal_grooming_behavior | 1.63948460 |
| 47 | MP0005386_behavior/neurological_phenoty | 1.61844923 |
| 48 | MP0004924_abnormal_behavior | 1.61844923 |
| 49 | MP0002822_catalepsy | 1.54276514 |
| 50 | MP0002184_abnormal_innervation | 1.49602948 |
| 51 | MP0004147_increased_porphyrin_level | 1.48045289 |
| 52 | MP0005075_abnormal_melanosome_morpholog | 1.45009986 |
| 53 | MP0005408_hypopigmentation | 1.42251864 |
| 54 | MP0003567_abnormal_fetal_cardiomyocyte | 1.41872598 |
| 55 | MP0005394_taste/olfaction_phenotype | 1.40022409 |
| 56 | MP0005499_abnormal_olfactory_system | 1.40022409 |
| 57 | MP0002557_abnormal_social/conspecific_i | 1.34209055 |
| 58 | MP0002638_abnormal_pupillary_reflex | 1.32289781 |
| 59 | MP0001970_abnormal_pain_threshold | 1.31604125 |
| 60 | MP0004145_abnormal_muscle_electrophysio | 1.30720374 |
| 61 | MP0003806_abnormal_nucleotide_metabolis | 1.29048582 |
| 62 | MP0003646_muscle_fatigue | 1.27984255 |
| 63 | MP0001929_abnormal_gametogenesis | 1.25958197 |
| 64 | MP0002733_abnormal_thermal_nociception | 1.25581105 |
| 65 | MP0008789_abnormal_olfactory_epithelium | 1.25312433 |
| 66 | MP0000778_abnormal_nervous_system | 1.23950830 |
| 67 | MP0002210_abnormal_sex_determination | 1.23755943 |
| 68 | MP0008872_abnormal_physiological_respon | 1.23284913 |
| 69 | MP0005409_darkened_coat_color | 1.22629133 |
| 70 | MP0003011_delayed_dark_adaptation | 1.18584830 |
| 71 | MP0002234_abnormal_pharynx_morphology | 1.17383998 |
| 72 | MP0005084_abnormal_gallbladder_morpholo | 1.15332495 |
| 73 | MP0004036_abnormal_muscle_relaxation | 1.15198689 |
| 74 | MP0002876_abnormal_thyroid_physiology | 1.12296734 |
| 75 | MP0000749_muscle_degeneration | 1.11704082 |
| 76 | MP0004215_abnormal_myocardial_fiber | 1.11183467 |
| 77 | MP0003937_abnormal_limbs/digits/tail_de | 1.11176400 |
| 78 | MP0005410_abnormal_fertilization | 1.11066784 |
| 79 | MP0005645_abnormal_hypothalamus_physiol | 1.09368061 |
| 80 | MP0000358_abnormal_cell_content/ | 1.08803313 |
| 81 | MP0001697_abnormal_embryo_size | 1.08646959 |
| 82 | MP0001485_abnormal_pinna_reflex | 1.06964732 |
| 83 | MP0001730_embryonic_growth_arrest | 1.06913934 |
| 84 | MP0000653_abnormal_sex_gland | 1.05843988 |
| 85 | MP0002095_abnormal_skin_pigmentation | 1.05484275 |
| 86 | MP0002066_abnormal_motor_capabilities/c | 1.04586120 |
| 87 | MP0004484_altered_response_of | 1.03723668 |
| 88 | MP0001145_abnormal_male_reproductive | 1.02965726 |
| 89 | MP0003195_calcinosis | 1.02725549 |
| 90 | MP0000955_abnormal_spinal_cord | 1.01614061 |
| 91 | MP0003137_abnormal_impulse_conducting | 1.00300430 |
| 92 | MP0003123_paternal_imprinting | 1.00157782 |
| 93 | MP0001286_abnormal_eye_development | 0.98872904 |
| 94 | MP0002882_abnormal_neuron_morphology | 0.97611159 |
| 95 | MP0010030_abnormal_orbit_morphology | 0.97465529 |
| 96 | MP0000350_abnormal_cell_proliferation | 0.95902282 |
| 97 | MP0005551_abnormal_eye_electrophysiolog | 0.95892923 |
| 98 | MP0008569_lethality_at_weaning | 0.94570664 |
| 99 | MP0010386_abnormal_urinary_bladder | 0.92387545 |
| 100 | MP0000049_abnormal_middle_ear | 0.91512205 |
| 101 | MP0004085_abnormal_heartbeat | 0.91265305 |
| 102 | MP0003698_abnormal_male_reproductive | 0.91202307 |
| 103 | MP0005535_abnormal_body_temperature | 0.90215330 |
| 104 | MP0008877_abnormal_DNA_methylation | 0.88893352 |
| 105 | MP0002229_neurodegeneration | 0.87997616 |
| 106 | MP0004133_heterotaxia | 0.87922397 |
| 107 | MP0005332_abnormal_amino_acid | 0.87852021 |
| 108 | MP0000313_abnormal_cell_death | 0.87774913 |
| 109 | MP0002090_abnormal_vision | 0.85967716 |
| 110 | MP0003941_abnormal_skin_development | 0.85568913 |
| 111 | MP0002752_abnormal_somatic_nervous | 0.84990714 |
| 112 | MP0001764_abnormal_homeostasis | 0.84630726 |
| 113 | MP0001963_abnormal_hearing_physiology | 0.83366542 |
| 114 | MP0002751_abnormal_autonomic_nervous | 0.83195695 |
| 115 | MP0003890_abnormal_embryonic-extraembry | 0.82816335 |
| 116 | MP0001672_abnormal_embryogenesis/_devel | 0.81738531 |
| 117 | MP0005380_embryogenesis_phenotype | 0.81738531 |
| 118 | MP0002160_abnormal_reproductive_system | 0.80910433 |
| 119 | MP0002332_abnormal_exercise_endurance | 0.79790846 |
| 120 | MP0000751_myopathy | 0.79624239 |
| 121 | MP0000631_abnormal_neuroendocrine_gland | 0.78682395 |
| 122 | MP0008875_abnormal_xenobiotic_pharmacok | 0.78425446 |
| 123 | MP0001324_abnormal_eye_pigmentation | 0.78068868 |
| 124 | MP0003950_abnormal_plasma_membrane | 0.77540468 |
| 125 | MP0003315_abnormal_perineum_morphology | 0.77528432 |
| 126 | MP0005391_vision/eye_phenotype | 0.76167953 |
| 127 | MP0002080_prenatal_lethality | 0.76090795 |
| 128 | MP0003121_genomic_imprinting | 0.75879769 |
| 129 | MP0002085_abnormal_embryonic_tissue | 0.74709224 |
| 130 | MP0002084_abnormal_developmental_patter | 0.73461606 |
| 131 | MP0005636_abnormal_mineral_homeostasis | 0.73103539 |
| 132 | MP0004811_abnormal_neuron_physiology | 0.73074587 |
| 133 | MP0000647_abnormal_sebaceous_gland | 0.72940479 |
| 134 | MP0002938_white_spotting | 0.72588003 |
| 135 | MP0001664_abnormal_digestion | 0.72537734 |
| 136 | MP0002928_abnormal_bile_duct | 0.72521162 |
| 137 | MP0005266_abnormal_metabolism | 0.72013200 |
| 138 | MP0001542_abnormal_bone_strength | 0.71754372 |
| 139 | MP0005171_absent_coat_pigmentation | 0.69977111 |
| 140 | MP0002233_abnormal_nose_morphology | 0.69869117 |
| 141 | MP0005395_other_phenotype | 0.69220129 |
| 142 | MP0003119_abnormal_digestive_system | 0.68944466 |
| 143 | MP0002132_abnormal_respiratory_system | 0.68882648 |
| 144 | MP0000372_irregular_coat_pigmentation | 0.68829878 |
| 145 | MP0001119_abnormal_female_reproductive | 0.68235284 |
| 146 | MP0002163_abnormal_gland_morphology | 0.68047496 |
| 147 | MP0002653_abnormal_ependyma_morphology | 0.67443992 |
| 148 | MP0000026_abnormal_inner_ear | 0.67171171 |
| 149 | MP0006072_abnormal_retinal_apoptosis | 0.66773893 |
| 150 | MP0000516_abnormal_urinary_system | 0.66373039 |
| 151 | MP0005620_abnormal_muscle_contractility | 0.65944404 |
| 152 | MP0008932_abnormal_embryonic_tissue | 0.64889163 |
| 153 | MP0003718_maternal_effect | 0.64703846 |
| 154 | MP0003136_yellow_coat_color | 0.64229923 |
| 155 | MP0002152_abnormal_brain_morphology | 0.63417374 |
| 156 | MP0002102_abnormal_ear_morphology | 0.61576459 |
| 157 | MP0005253_abnormal_eye_physiology | 0.60730811 |
| 158 | MP0002069_abnormal_eating/drinking_beha | 0.60369159 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 6.69818105 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 6.19060047 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.98695814 |
| 4 | Progressive macrocephaly (HP:0004481) | 5.79670300 |
| 5 | Acute encephalopathy (HP:0006846) | 5.65698754 |
| 6 | Increased CSF lactate (HP:0002490) | 5.25573162 |
| 7 | Hepatocellular necrosis (HP:0001404) | 5.10489759 |
| 8 | Abnormality of glycolysis (HP:0004366) | 4.78368207 |
| 9 | Increased serum pyruvate (HP:0003542) | 4.78368207 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 4.70477222 |
| 11 | Hepatic necrosis (HP:0002605) | 4.49543007 |
| 12 | Lipid accumulation in hepatocytes (HP:0006561) | 4.26740728 |
| 13 | Cerebral edema (HP:0002181) | 4.16728428 |
| 14 | 3-Methylglutaconic aciduria (HP:0003535) | 3.82423202 |
| 15 | Lactic acidosis (HP:0003128) | 3.80583365 |
| 16 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.80200533 |
| 17 | Neuroendocrine neoplasm (HP:0100634) | 3.73093146 |
| 18 | Focal motor seizures (HP:0011153) | 3.71977798 |
| 19 | Renal Fanconi syndrome (HP:0001994) | 3.66657642 |
| 20 | Increased serum lactate (HP:0002151) | 3.66418758 |
| 21 | Pheochromocytoma (HP:0002666) | 3.63590383 |
| 22 | Respiratory failure (HP:0002878) | 3.50974074 |
| 23 | Optic disc pallor (HP:0000543) | 3.50750477 |
| 24 | Exercise intolerance (HP:0003546) | 3.44819509 |
| 25 | Increased intramyocellular lipid droplets (HP:0012240) | 3.42651546 |
| 26 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.37552089 |
| 27 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.37095866 |
| 28 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.37095866 |
| 29 | Abnormality of alanine metabolism (HP:0010916) | 3.34295176 |
| 30 | Hyperalaninemia (HP:0003348) | 3.34295176 |
| 31 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.34295176 |
| 32 | Leukodystrophy (HP:0002415) | 3.33367747 |
| 33 | Atonic seizures (HP:0010819) | 3.32723813 |
| 34 | Hyperventilation (HP:0002883) | 3.18551913 |
| 35 | Reticulocytopenia (HP:0001896) | 3.18137599 |
| 36 | Myokymia (HP:0002411) | 2.93309719 |
| 37 | Microvesicular hepatic steatosis (HP:0001414) | 2.90753185 |
| 38 | Increased muscle lipid content (HP:0009058) | 2.86668397 |
| 39 | Epileptic encephalopathy (HP:0200134) | 2.85742866 |
| 40 | Respiratory difficulties (HP:0002880) | 2.78494851 |
| 41 | Abnormal hair whorl (HP:0010721) | 2.77140480 |
| 42 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.73855068 |
| 43 | Chromsome breakage (HP:0040012) | 2.71232535 |
| 44 | Exertional dyspnea (HP:0002875) | 2.70288236 |
| 45 | X-linked dominant inheritance (HP:0001423) | 2.63878575 |
| 46 | Hyperglycinemia (HP:0002154) | 2.63212030 |
| 47 | Meckel diverticulum (HP:0002245) | 2.60997973 |
| 48 | Hypothermia (HP:0002045) | 2.54482936 |
| 49 | Abnormality of the ileum (HP:0001549) | 2.51927505 |
| 50 | Type I transferrin isoform profile (HP:0003642) | 2.49132971 |
| 51 | Febrile seizures (HP:0002373) | 2.47522929 |
| 52 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.43076506 |
| 53 | Gait imbalance (HP:0002141) | 2.42976351 |
| 54 | Abnormality of the preputium (HP:0100587) | 2.37903294 |
| 55 | Abnormality of renal resorption (HP:0011038) | 2.37892926 |
| 56 | CNS demyelination (HP:0007305) | 2.35979990 |
| 57 | Abnormality of methionine metabolism (HP:0010901) | 2.34659998 |
| 58 | Pancreatic cysts (HP:0001737) | 2.33204903 |
| 59 | Medial flaring of the eyebrow (HP:0010747) | 2.33164947 |
| 60 | Congenital primary aphakia (HP:0007707) | 2.31593277 |
| 61 | Cerebral hypomyelination (HP:0006808) | 2.31501411 |
| 62 | Abnormality of serum amino acid levels (HP:0003112) | 2.29006153 |
| 63 | Abnormality of chromosome stability (HP:0003220) | 2.27483081 |
| 64 | Emotional lability (HP:0000712) | 2.27437882 |
| 65 | Pancreatic fibrosis (HP:0100732) | 2.26658366 |
| 66 | Nephrogenic diabetes insipidus (HP:0009806) | 2.25597645 |
| 67 | Lethargy (HP:0001254) | 2.25051008 |
| 68 | Colon cancer (HP:0003003) | 2.21502264 |
| 69 | Absence seizures (HP:0002121) | 2.17753839 |
| 70 | Pancytopenia (HP:0001876) | 2.17079660 |
| 71 | Abnormality of the anterior horn cell (HP:0006802) | 2.14884992 |
| 72 | Degeneration of anterior horn cells (HP:0002398) | 2.14884992 |
| 73 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.12672883 |
| 74 | Molar tooth sign on MRI (HP:0002419) | 2.10968113 |
| 75 | Abnormality of midbrain morphology (HP:0002418) | 2.10968113 |
| 76 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.08465529 |
| 77 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.08465529 |
| 78 | Abnormal protein glycosylation (HP:0012346) | 2.08465529 |
| 79 | Abnormal glycosylation (HP:0012345) | 2.08465529 |
| 80 | Pallor (HP:0000980) | 2.07920140 |
| 81 | Focal seizures (HP:0007359) | 2.06214345 |
| 82 | Generalized tonic-clonic seizures (HP:0002069) | 1.99940186 |
| 83 | True hermaphroditism (HP:0010459) | 1.97763777 |
| 84 | Dialeptic seizures (HP:0011146) | 1.97409509 |
| 85 | Methylmalonic acidemia (HP:0002912) | 1.96824807 |
| 86 | Duodenal stenosis (HP:0100867) | 1.94889262 |
| 87 | Small intestinal stenosis (HP:0012848) | 1.94889262 |
| 88 | Reduced antithrombin III activity (HP:0001976) | 1.93565125 |
| 89 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.92878229 |
| 90 | Sensory axonal neuropathy (HP:0003390) | 1.92737259 |
| 91 | Dicarboxylic aciduria (HP:0003215) | 1.92254487 |
| 92 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.92254487 |
| 93 | Broad-based gait (HP:0002136) | 1.92023314 |
| 94 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.91958077 |
| 95 | Anxiety (HP:0000739) | 1.91936710 |
| 96 | Triphalangeal thumb (HP:0001199) | 1.91697198 |
| 97 | Autoamputation (HP:0001218) | 1.91538635 |
| 98 | Oral leukoplakia (HP:0002745) | 1.91114010 |
| 99 | Ragged-red muscle fibers (HP:0003200) | 1.91033053 |
| 100 | Genital tract atresia (HP:0001827) | 1.90883280 |
| 101 | Hypoglycemic coma (HP:0001325) | 1.90866445 |
| 102 | Limb dystonia (HP:0002451) | 1.90437564 |
| 103 | Generalized aminoaciduria (HP:0002909) | 1.90195972 |
| 104 | Congenital, generalized hypertrichosis (HP:0004540) | 1.89680964 |
| 105 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.88791734 |
| 106 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.88791734 |
| 107 | Vaginal atresia (HP:0000148) | 1.88502329 |
| 108 | Poor suck (HP:0002033) | 1.86986337 |
| 109 | Glycosuria (HP:0003076) | 1.82881688 |
| 110 | Abnormality of urine glucose concentration (HP:0011016) | 1.82881688 |
| 111 | Progressive inability to walk (HP:0002505) | 1.80559462 |
| 112 | Megaloblastic anemia (HP:0001889) | 1.80295916 |
| 113 | Absent thumb (HP:0009777) | 1.80056196 |
| 114 | Poor coordination (HP:0002370) | 1.80049339 |
| 115 | Methylmalonic aciduria (HP:0012120) | 1.79712937 |
| 116 | Abnormal lung lobation (HP:0002101) | 1.79284175 |
| 117 | Macrocytic anemia (HP:0001972) | 1.78897500 |
| 118 | Delayed CNS myelination (HP:0002188) | 1.78370276 |
| 119 | Abnormality of the duodenum (HP:0002246) | 1.77821839 |
| 120 | Cerebral hemorrhage (HP:0001342) | 1.77619266 |
| 121 | Gliosis (HP:0002171) | 1.76880238 |
| 122 | Unsteady gait (HP:0002317) | 1.76247588 |
| 123 | Hypoplastic left heart (HP:0004383) | 1.76188711 |
| 124 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.75826673 |
| 125 | Abnormality of glycine metabolism (HP:0010895) | 1.75826673 |
| 126 | Muscle hypertrophy of the lower extremities (HP:0008968) | 1.73820965 |
| 127 | Bile duct proliferation (HP:0001408) | 1.72573717 |
| 128 | Abnormal biliary tract physiology (HP:0012439) | 1.72573717 |
| 129 | Horseshoe kidney (HP:0000085) | 1.72358731 |
| 130 | Abnormal number of erythroid precursors (HP:0012131) | 1.70936839 |
| 131 | Delusions (HP:0000746) | 1.70808576 |
| 132 | Birth length less than 3rd percentile (HP:0003561) | 1.70645564 |
| 133 | Aplastic anemia (HP:0001915) | 1.70290114 |
| 134 | Breast hypoplasia (HP:0003187) | 1.70197616 |
| 135 | Myotonia (HP:0002486) | 1.70030051 |
| 136 | CNS hypomyelination (HP:0003429) | 1.69727454 |
| 137 | Hyperphosphaturia (HP:0003109) | 1.68015768 |
| 138 | Abnormal gallbladder physiology (HP:0012438) | 1.67820950 |
| 139 | Cholecystitis (HP:0001082) | 1.67820950 |
| 140 | Renal tubular dysfunction (HP:0000124) | 1.66337336 |
| 141 | Conjunctival hamartoma (HP:0100780) | 1.66069242 |
| 142 | Inability to walk (HP:0002540) | 1.65775941 |
| 143 | Progressive cerebellar ataxia (HP:0002073) | 1.64479316 |
| 144 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.64243020 |
| 145 | Palpitations (HP:0001962) | 1.63107241 |
| 146 | Delayed gross motor development (HP:0002194) | 1.62496239 |
| 147 | Blindness (HP:0000618) | 1.61818647 |
| 148 | Abnormality of the labia minora (HP:0012880) | 1.60524860 |
| 149 | Female pseudohermaphroditism (HP:0010458) | 1.59459709 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 4.72165141 |
| 2 | VRK2 | 4.01644585 |
| 3 | MAP2K7 | 3.45947400 |
| 4 | MAP3K12 | 3.44871793 |
| 5 | CDC7 | 2.90137183 |
| 6 | MAP3K4 | 2.82730172 |
| 7 | STK16 | 2.77338761 |
| 8 | ARAF | 2.65488938 |
| 9 | NME1 | 2.60245492 |
| 10 | TTK | 2.16990886 |
| 11 | NUAK1 | 2.14221905 |
| 12 | MAP4K2 | 2.11464077 |
| 13 | BCR | 2.09448353 |
| 14 | PLK4 | 2.08310576 |
| 15 | CDK19 | 1.96988954 |
| 16 | TRIM28 | 1.85508153 |
| 17 | NTRK3 | 1.83055392 |
| 18 | BUB1 | 1.80698555 |
| 19 | OXSR1 | 1.68830534 |
| 20 | MAP2K4 | 1.64331553 |
| 21 | EIF2AK1 | 1.63414439 |
| 22 | TSSK6 | 1.63242435 |
| 23 | WNK3 | 1.60591987 |
| 24 | STK39 | 1.55031054 |
| 25 | PLK2 | 1.51908973 |
| 26 | MUSK | 1.50365551 |
| 27 | NME2 | 1.49832006 |
| 28 | BRAF | 1.49124949 |
| 29 | SIK3 | 1.46939593 |
| 30 | VRK1 | 1.46329652 |
| 31 | LIMK1 | 1.45413874 |
| 32 | EPHA4 | 1.44120917 |
| 33 | ACVR1B | 1.40847342 |
| 34 | PLK1 | 1.39172858 |
| 35 | MYLK | 1.39103816 |
| 36 | PASK | 1.35752314 |
| 37 | BMPR1B | 1.34362985 |
| 38 | CDK8 | 1.33029801 |
| 39 | MINK1 | 1.31726902 |
| 40 | AKT3 | 1.30882994 |
| 41 | MKNK1 | 1.28974804 |
| 42 | MAPK13 | 1.27732166 |
| 43 | GRK5 | 1.27461212 |
| 44 | BCKDK | 1.26993489 |
| 45 | CSNK1G3 | 1.22306699 |
| 46 | CCNB1 | 1.21902836 |
| 47 | TNIK | 1.16807091 |
| 48 | PNCK | 1.12234421 |
| 49 | MKNK2 | 1.11536342 |
| 50 | TAF1 | 1.09586931 |
| 51 | EIF2AK3 | 1.09014209 |
| 52 | ATR | 1.06223943 |
| 53 | OBSCN | 1.05646293 |
| 54 | PDK2 | 1.05103311 |
| 55 | GRK1 | 1.04738685 |
| 56 | ADRBK2 | 1.01909569 |
| 57 | MAP3K9 | 0.98610207 |
| 58 | AURKB | 0.97722745 |
| 59 | MST4 | 0.96946995 |
| 60 | MARK1 | 0.96826985 |
| 61 | PDK4 | 0.93907447 |
| 62 | PDK3 | 0.93907447 |
| 63 | TNK2 | 0.93556542 |
| 64 | CSNK1G2 | 0.92279408 |
| 65 | DYRK3 | 0.91957822 |
| 66 | DAPK1 | 0.89389169 |
| 67 | CAMK2B | 0.88940542 |
| 68 | WEE1 | 0.88913399 |
| 69 | CAMK2A | 0.87770796 |
| 70 | CHEK2 | 0.87483063 |
| 71 | MAPKAPK5 | 0.86980567 |
| 72 | UHMK1 | 0.85283394 |
| 73 | GRK7 | 0.80783032 |
| 74 | PLK3 | 0.80540393 |
| 75 | BRSK1 | 0.77342800 |
| 76 | BMPR2 | 0.75774502 |
| 77 | DYRK2 | 0.74913334 |
| 78 | CSNK2A2 | 0.73579071 |
| 79 | INSRR | 0.72945827 |
| 80 | PBK | 0.71694633 |
| 81 | SRPK1 | 0.70238598 |
| 82 | CSNK1G1 | 0.69991275 |
| 83 | ADRBK1 | 0.69499902 |
| 84 | CSNK2A1 | 0.68477357 |
| 85 | ERBB4 | 0.68150114 |
| 86 | TIE1 | 0.67719829 |
| 87 | STK4 | 0.66664372 |
| 88 | EIF2AK2 | 0.66467072 |
| 89 | NEK2 | 0.65986813 |
| 90 | RPS6KA5 | 0.65984074 |
| 91 | ATM | 0.65346925 |
| 92 | CDK7 | 0.64528680 |
| 93 | KSR1 | 0.63829076 |
| 94 | CAMK2D | 0.61422650 |
| 95 | CDK18 | 0.60835501 |
| 96 | CSNK1A1L | 0.60103271 |
| 97 | PRKCG | 0.59531693 |
| 98 | PRPF4B | 0.58783258 |
| 99 | CAMKK2 | 0.58169165 |
| 100 | PIK3CA | 0.57954755 |
| 101 | SGK223 | 0.57210773 |
| 102 | SGK494 | 0.57210773 |
| 103 | SCYL2 | 0.56885803 |
| 104 | CDK14 | 0.56727317 |
| 105 | CHEK1 | 0.56227750 |
| 106 | CDK5 | 0.55194816 |
| 107 | MAP3K6 | 0.54703644 |
| 108 | AURKA | 0.53881076 |
| 109 | FRK | 0.53324223 |
| 110 | RPS6KA4 | 0.52619183 |
| 111 | ERBB3 | 0.52565004 |
| 112 | NEK1 | 0.52333793 |
| 113 | WNK4 | 0.51653110 |
| 114 | TLK1 | 0.50408429 |
| 115 | CAMK2G | 0.50405896 |
| 116 | PRKCE | 0.50020861 |
| 117 | KDR | 0.49408611 |
| 118 | YES1 | 0.48964902 |
| 119 | NEK6 | 0.48485354 |
| 120 | CDK3 | 0.48405933 |
| 121 | RAF1 | 0.48219042 |
| 122 | SGK2 | 0.48138075 |
| 123 | CDK15 | 0.48028430 |
| 124 | TEC | 0.46504268 |
| 125 | PHKG1 | 0.44775897 |
| 126 | PHKG2 | 0.44775897 |
| 127 | PIM2 | 0.44556713 |
| 128 | CDK11A | 0.43925746 |
| 129 | CLK1 | 0.43821066 |
| 130 | PINK1 | 0.43372049 |
| 131 | BRSK2 | 0.42177035 |
| 132 | ZAK | 0.41944685 |
| 133 | PRKACA | 0.41599112 |
| 134 | DYRK1A | 0.41551368 |
| 135 | TESK2 | 0.41039239 |
| 136 | STK3 | 0.40878718 |
| 137 | ABL2 | 0.40110071 |
| 138 | STK38L | 0.37121362 |
| 139 | CSNK1E | 0.35712318 |
| 140 | PAK4 | 0.31641301 |
| 141 | MAP3K8 | 0.29969890 |
| 142 | CDK1 | 0.29903852 |
| 143 | FLT3 | 0.29592296 |
| 144 | CSNK1A1 | 0.27364355 |
| 145 | CDK2 | 0.26551964 |
| 146 | ILK | 0.25357028 |
| 147 | ALK | 0.25324062 |
| 148 | LRRK2 | 0.24648496 |
| 149 | PRKDC | 0.24592944 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.70736371 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 4.96770725 |
| 3 | Alzheimers disease_Homo sapiens_hsa05010 | 3.74551668 |
| 4 | Huntingtons disease_Homo sapiens_hsa05016 | 3.52059826 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 3.25957394 |
| 6 | Ribosome_Homo sapiens_hsa03010 | 3.24086182 |
| 7 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.81183872 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.59766063 |
| 9 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.50732253 |
| 10 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.39449503 |
| 11 | Protein export_Homo sapiens_hsa03060 | 2.26529118 |
| 12 | Nicotine addiction_Homo sapiens_hsa05033 | 2.26475892 |
| 13 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.19809628 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.99366429 |
| 15 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.95632907 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.87849958 |
| 17 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.74745219 |
| 18 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.71827264 |
| 19 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.58787289 |
| 20 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.57563666 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.57117744 |
| 22 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.54664095 |
| 23 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.46831264 |
| 24 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.44711710 |
| 25 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.40231191 |
| 26 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.29388398 |
| 27 | Cell cycle_Homo sapiens_hsa04110 | 1.20750404 |
| 28 | GABAergic synapse_Homo sapiens_hsa04727 | 1.20400116 |
| 29 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.17438511 |
| 30 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.16943384 |
| 31 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.14485557 |
| 32 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.14272472 |
| 33 | Taste transduction_Homo sapiens_hsa04742 | 1.11078995 |
| 34 | Purine metabolism_Homo sapiens_hsa00230 | 1.00988044 |
| 35 | Phototransduction_Homo sapiens_hsa04744 | 1.00200127 |
| 36 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.99079513 |
| 37 | Morphine addiction_Homo sapiens_hsa05032 | 0.98206031 |
| 38 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.98014713 |
| 39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.97563958 |
| 40 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.96714835 |
| 41 | Basal transcription factors_Homo sapiens_hsa03022 | 0.95413683 |
| 42 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.95117278 |
| 43 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.94273888 |
| 44 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.94118013 |
| 45 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.89678083 |
| 46 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.86570200 |
| 47 | Metabolic pathways_Homo sapiens_hsa01100 | 0.86125863 |
| 48 | Olfactory transduction_Homo sapiens_hsa04740 | 0.85349505 |
| 49 | Carbon metabolism_Homo sapiens_hsa01200 | 0.84700250 |
| 50 | Circadian entrainment_Homo sapiens_hsa04713 | 0.83739427 |
| 51 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.82468719 |
| 52 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.82047433 |
| 53 | Sulfur relay system_Homo sapiens_hsa04122 | 0.81452242 |
| 54 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.78214807 |
| 55 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.76386981 |
| 56 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.76089366 |
| 57 | Spliceosome_Homo sapiens_hsa03040 | 0.75936363 |
| 58 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.74982603 |
| 59 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.74876891 |
| 60 | RNA degradation_Homo sapiens_hsa03018 | 0.74725877 |
| 61 | Long-term potentiation_Homo sapiens_hsa04720 | 0.72915470 |
| 62 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.70208228 |
| 63 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.68887939 |
| 64 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.63853451 |
| 65 | Homologous recombination_Homo sapiens_hsa03440 | 0.63738500 |
| 66 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.63342223 |
| 67 | Mismatch repair_Homo sapiens_hsa03430 | 0.62387335 |
| 68 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.62080555 |
| 69 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.60213017 |
| 70 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.58530787 |
| 71 | Peroxisome_Homo sapiens_hsa04146 | 0.58523914 |
| 72 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.57830546 |
| 73 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.57250515 |
| 74 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.57005734 |
| 75 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.56826819 |
| 76 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.56003921 |
| 77 | Cocaine addiction_Homo sapiens_hsa05030 | 0.54616444 |
| 78 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.51840154 |
| 79 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.51222872 |
| 80 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.51013185 |
| 81 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.50994351 |
| 82 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.49359240 |
| 83 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.49216199 |
| 84 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.47014378 |
| 85 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.46121438 |
| 86 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.46112251 |
| 87 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44994942 |
| 88 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.44799995 |
| 89 | DNA replication_Homo sapiens_hsa03030 | 0.44203365 |
| 90 | Salivary secretion_Homo sapiens_hsa04970 | 0.43778713 |
| 91 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.43611727 |
| 92 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.43440819 |
| 93 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.42780118 |
| 94 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.42499127 |
| 95 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.41773131 |
| 96 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.41722266 |
| 97 | Long-term depression_Homo sapiens_hsa04730 | 0.41634133 |
| 98 | RNA transport_Homo sapiens_hsa03013 | 0.41348827 |
| 99 | Retinol metabolism_Homo sapiens_hsa00830 | 0.39681809 |
| 100 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.39540154 |
| 101 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.38698959 |
| 102 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.37570522 |
| 103 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.35449601 |
| 104 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.34882408 |
| 105 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.34314715 |
| 106 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.33860851 |
| 107 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.33070063 |
| 108 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.31014627 |
| 109 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.29365682 |
| 110 | Renin secretion_Homo sapiens_hsa04924 | 0.28946497 |
| 111 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.27802255 |
| 112 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.27353009 |
| 113 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.27318913 |
| 114 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.27191738 |
| 115 | Alcoholism_Homo sapiens_hsa05034 | 0.26733782 |
| 116 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.26452614 |
| 117 | Insulin secretion_Homo sapiens_hsa04911 | 0.26280070 |
| 118 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.24586376 |
| 119 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.23828815 |
| 120 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.22017515 |
| 121 | Histidine metabolism_Homo sapiens_hsa00340 | 0.21217616 |
| 122 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.20776026 |
| 123 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.20508401 |
| 124 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.20099645 |
| 125 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.20097991 |
| 126 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.18692683 |
| 127 | Phagosome_Homo sapiens_hsa04145 | 0.17933052 |
| 128 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.17293274 |
| 129 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.17219710 |
| 130 | Base excision repair_Homo sapiens_hsa03410 | 0.17194012 |
| 131 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.17090800 |
| 132 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.17035609 |
| 133 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.16654309 |
| 134 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.16551128 |
| 135 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.15215696 |

