ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.04361785
2	negative regulation of telomere maintenance (GO:0032205)	3.81597840
3	epithelial cilium movement (GO:0003351)	3.72254564
4	indole-containing compound catabolic process (GO:0042436)	3.57933849
5	indolalkylamine catabolic process (GO:0046218)	3.57933849
6	tryptophan catabolic process (GO:0006569)	3.57933849
7	tryptophan metabolic process (GO:0006568)	3.49947339
8	histone H3-K4 trimethylation (GO:0080182)	3.46227125
9	cell wall macromolecule catabolic process (GO:0016998)	3.43006702
10	cilium movement (GO:0003341)	3.30390534
11	positive regulation of gamma-delta T cell activation (GO:0046645)	3.30365861
12	cell wall macromolecule metabolic process (GO:0044036)	3.26141405
13	regulation of cilium movement (GO:0003352)	3.25746233
14	fucose catabolic process (GO:0019317)	3.22001505
15	L-fucose metabolic process (GO:0042354)	3.22001505
16	L-fucose catabolic process (GO:0042355)	3.22001505
17	behavioral response to nicotine (GO:0035095)	3.14991212
18	regulation of gamma-delta T cell differentiation (GO:0045586)	3.14556304
19	cellular response to interleukin-15 (GO:0071350)	3.10101162
20	indolalkylamine metabolic process (GO:0006586)	3.09092718
21	positive regulation of defense response to virus by host (GO:0002230)	3.07476347
22	positive T cell selection (GO:0043368)	3.07188195
23	establishment of protein localization to Golgi (GO:0072600)	3.06385196
24	negative T cell selection (GO:0043383)	2.98694227
25	preassembly of GPI anchor in ER membrane (GO:0016254)	2.94364340
26	axonemal dynein complex assembly (GO:0070286)	2.90069102
27	regulation of gamma-delta T cell activation (GO:0046643)	2.89330932
28	mast cell degranulation (GO:0043303)	2.88304981
29	mast cell activation involved in immune response (GO:0002279)	2.88304981
30	axoneme assembly (GO:0035082)	2.87215282
31	protein polyglutamylation (GO:0018095)	2.87093989
32	negative thymic T cell selection (GO:0045060)	2.86330270
33	protein targeting to Golgi (GO:0000042)	2.83106173
34	aggressive behavior (GO:0002118)	2.81882977
35	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.81674341
36	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.80183969
37	S-adenosylmethionine metabolic process (GO:0046500)	2.75746327
38	protein localization to Golgi apparatus (GO:0034067)	2.75128577
39	DNA deamination (GO:0045006)	2.74994569
40	amine catabolic process (GO:0009310)	2.73734917
41	cellular biogenic amine catabolic process (GO:0042402)	2.73734917
42	regulation of telomere maintenance (GO:0032204)	2.72696306
43	peptidyl-lysine trimethylation (GO:0018023)	2.71725079
44	response to pheromone (GO:0019236)	2.71017808
45	protein K11-linked deubiquitination (GO:0035871)	2.69939790
46	sperm motility (GO:0030317)	2.69731961
47	negative regulation of cell cycle arrest (GO:0071157)	2.69346832
48	pyrimidine nucleobase catabolic process (GO:0006208)	2.69269067
49	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.68417598
50	actin nucleation (GO:0045010)	2.66901734
51	regulation of B cell receptor signaling pathway (GO:0050855)	2.65616661
52	NAD biosynthetic process (GO:0009435)	2.65312319
53	cilium morphogenesis (GO:0060271)	2.64347001
54	dentate gyrus development (GO:0021542)	2.63425270
55	arginine catabolic process (GO:0006527)	2.62886354
56	positive regulation of protein homodimerization activity (GO:0090073)	2.62688938
57	lysosome localization (GO:0032418)	2.62393690
58	cilium or flagellum-dependent cell motility (GO:0001539)	2.62196766
59	histone H3-K9 methylation (GO:0051567)	2.59547775
60	adenosine metabolic process (GO:0046085)	2.58710768
61	interferon-gamma production (GO:0032609)	2.57024402
62	positive regulation of calcium-mediated signaling (GO:0050850)	2.56225134
63	mannosylation (GO:0097502)	2.55825940
64	ubiquinone biosynthetic process (GO:0006744)	2.55163394
65	seminiferous tubule development (GO:0072520)	2.53905436
66	multicellular organism reproduction (GO:0032504)	2.53264254
67	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.52744227
68	motile cilium assembly (GO:0044458)	2.50585813
69	forebrain neuron differentiation (GO:0021879)	2.48911048
70	regulation of germinal center formation (GO:0002634)	2.46895267
71	intraciliary transport (GO:0042073)	2.46688940
72	maintenance of protein location in nucleus (GO:0051457)	2.45742350
73	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.45053908
74	cilium organization (GO:0044782)	2.42062316
75	negative regulation of DNA binding (GO:0043392)	2.41542704
76	activated T cell proliferation (GO:0050798)	2.40880575
77	regulation of defense response to virus by host (GO:0050691)	2.40463595
78	positive regulation of fatty acid transport (GO:2000193)	2.36826536
79	T cell selection (GO:0045058)	2.35946189
80	cilium assembly (GO:0042384)	2.35258087
81	base-excision repair, AP site formation (GO:0006285)	2.35171615
82	response to interleukin-15 (GO:0070672)	2.34418046
83	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.34115481
84	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.34115481
85	regulation of translation, ncRNA-mediated (GO:0045974)	2.34115481
86	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.32834234
87	regulation of T cell mediated cytotoxicity (GO:0001914)	2.32323536
88	quinone biosynthetic process (GO:1901663)	2.32121166
89	positive regulation of organic acid transport (GO:0032892)	2.31968842
90	phosphatidylethanolamine metabolic process (GO:0046337)	2.30437199
91	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.29676848
92	positive regulation of icosanoid secretion (GO:0032305)	2.28356244
93	regulation of autophagic vacuole assembly (GO:2000785)	2.27880889
94	ubiquinone metabolic process (GO:0006743)	2.27333945
95	neural tube formation (GO:0001841)	2.27206431
96	somite development (GO:0061053)	2.27090994
97	mast cell activation (GO:0045576)	2.26445821
98	male meiosis (GO:0007140)	2.26124354
99	positive regulation of granulocyte differentiation (GO:0030854)	2.26117381
100	sulfation (GO:0051923)	2.24999438

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.40507864
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.36883951
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.89017886
4	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.80083781
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.69626851
6	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.37625925
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.29992652
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.28999157
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22151586
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.21114171
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.13912246
12	* ER_23166858_ChIP-Seq_MCF-7_Human	2.12762450
13	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.09286264
14	IRF1_19129219_ChIP-ChIP_H3396_Human	1.98776645
15	VDR_22108803_ChIP-Seq_LS180_Human	1.91977455
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.89248373
17	SCL_19346495_ChIP-Seq_HPC-7_Human	1.84119595
18	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.78480974
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.71327891
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.70159481
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.69544476
22	RUNX_20019798_ChIP-Seq_JUKART_Human	1.64825895
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64619412
24	ERA_21632823_ChIP-Seq_H3396_Human	1.63137641
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59884141
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.57611483
27	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.48665946
28	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.46948342
29	CIITA_25753668_ChIP-Seq_RAJI_Human	1.45195506
30	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.41054969
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.40503964
32	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.37691161
33	GATA3_26560356_Chip-Seq_TH2_Human	1.35280461
34	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34292320
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.33815315
36	BCL6_27268052_Chip-Seq_Bcells_Human	1.32681713
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.32616650
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32219133
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.32219133
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31801049
41	MYB_26560356_Chip-Seq_TH2_Human	1.29803555
42	GATA3_27048872_Chip-Seq_THYMUS_Human	1.29245478
43	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.26007787
44	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.25167524
45	RAC3_21632823_ChIP-Seq_H3396_Human	1.23290133
46	* WDR5_24793694_ChIP-Seq_LNCAP_Human	1.22166293
47	MAF_26560356_Chip-Seq_TH2_Human	1.19140214
48	AR_21572438_ChIP-Seq_LNCaP_Human	1.17427308
49	OCT4_20526341_ChIP-Seq_ESCs_Human	1.16022782
50	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15164065
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.14792243
52	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.14761632
53	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12350086
54	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.11951089
55	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.11303360
56	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.11161334
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.10822752
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10822752
59	MYC_19829295_ChIP-Seq_ESCs_Human	1.10097205
60	AHR_22903824_ChIP-Seq_MCF-7_Human	1.09924059
61	DROSHA_22980978_ChIP-Seq_HELA_Human	1.09771497
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07386064
63	SPI1_23127762_ChIP-Seq_K562_Human	1.06582275
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05261411
65	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.04246804
66	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.04231816
67	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03207190
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01796912
69	P300_27268052_Chip-Seq_Bcells_Human	1.01285830
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.01054028
71	RXR_22108803_ChIP-Seq_LS180_Human	1.00049228
72	STAT1_20625510_ChIP-Seq_HELA_Human	0.99497376
73	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98447331
74	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.95332474
75	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95031056
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94701184
77	TCF4_23295773_ChIP-Seq_U87_Human	0.94663832
78	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.94257227
79	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.93832415
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.92503287
81	NCOR_22424771_ChIP-Seq_293T_Human	0.92385897
82	* OCT4_19829295_ChIP-Seq_ESCs_Human	0.92332408
83	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91787244
84	SMRT_27268052_Chip-Seq_Bcells_Human	0.91565764
85	E2F1_20622854_ChIP-Seq_HELA_Human	0.91178095
86	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.90943561
87	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.90771378
88	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90505295
89	VDR_23849224_ChIP-Seq_CD4+_Human	0.88739874
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88392747
91	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.88283355
92	STAT3_23295773_ChIP-Seq_U87_Human	0.87874175
93	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.87549013
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.86717321
95	P300_19829295_ChIP-Seq_ESCs_Human	0.86531801
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.86373550
97	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.86264020
98	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.85569817
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.85122081
100	* PHF8_20622854_ChIP-Seq_HELA_Human	0.84912875

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	3.10502111
2	MP0003646_muscle_fatigue	2.58180265
3	MP0002102_abnormal_ear_morphology	2.54083676
4	MP0000569_abnormal_digit_pigmentation	2.45878848
5	MP0005075_abnormal_melanosome_morpholog	2.38259853
6	MP0005671_abnormal_response_to	2.14119290
7	MP0000015_abnormal_ear_pigmentation	2.10670516
8	MP0006276_abnormal_autonomic_nervous	2.09621853
9	MP0003787_abnormal_imprinting	2.04284729
10	MP0003806_abnormal_nucleotide_metabolis	2.03490741
11	MP0003763_abnormal_thymus_physiology	1.96805689
12	MP0002132_abnormal_respiratory_system	1.91997138
13	MP0003724_increased_susceptibility_to	1.90311080
14	MP0005410_abnormal_fertilization	1.89819020
15	MP0002837_dystrophic_cardiac_calcinosis	1.84408182
16	MP0002638_abnormal_pupillary_reflex	1.83766939
17	MP0005646_abnormal_pituitary_gland	1.81943697
18	MP0004147_increased_porphyrin_level	1.74286484
19	MP0001984_abnormal_olfaction	1.70855129
20	MP0009278_abnormal_bone_marrow	1.70031536
21	MP0005174_abnormal_tail_pigmentation	1.67747158
22	MP0005645_abnormal_hypothalamus_physiol	1.67032271
23	MP0006292_abnormal_olfactory_placode	1.65554146
24	MP0001545_abnormal_hematopoietic_system	1.62931912
25	MP0005397_hematopoietic_system_phenotyp	1.62931912
26	MP0008877_abnormal_DNA_methylation	1.53499229
27	MP0000372_irregular_coat_pigmentation	1.51991208
28	MP0005423_abnormal_somatic_nervous	1.49110492
29	MP0001800_abnormal_humoral_immune	1.48909374
30	MP0008995_early_reproductive_senescence	1.47440225
31	MP0004142_abnormal_muscle_tone	1.46696124
32	MP0003136_yellow_coat_color	1.43792089
33	MP0004043_abnormal_pH_regulation	1.42789444
34	MP0000465_gastrointestinal_hemorrhage	1.42226550
35	MP0005551_abnormal_eye_electrophysiolog	1.35208085
36	MP0003880_abnormal_central_pattern	1.34764452
37	MP0002138_abnormal_hepatobiliary_system	1.34693186
38	MP0003656_abnormal_erythrocyte_physiolo	1.33963931
39	MP0001835_abnormal_antigen_presentation	1.33069250
40	MP0005167_abnormal_blood-brain_barrier	1.28609943
41	MP0005499_abnormal_olfactory_system	1.27527767
42	MP0005394_taste/olfaction_phenotype	1.27527767
43	MP0002095_abnormal_skin_pigmentation	1.27405945
44	MP0004145_abnormal_muscle_electrophysio	1.20597569
45	MP0006036_abnormal_mitochondrial_physio	1.20559438
46	MP0009046_muscle_twitch	1.20483248
47	MP0002723_abnormal_immune_serum	1.19641149
48	MP0001485_abnormal_pinna_reflex	1.17098293
49	MP0003172_abnormal_lysosome_physiology	1.15436605
50	MP0002420_abnormal_adaptive_immunity	1.14391639
51	MP0001819_abnormal_immune_cell	1.13973324
52	MP0001968_abnormal_touch/_nociception	1.09246226
53	MP0008872_abnormal_physiological_respon	1.08004225
54	MP0005253_abnormal_eye_physiology	1.07543717
55	MP0002452_abnormal_antigen_presenting	1.05720673
56	MP0006072_abnormal_retinal_apoptosis	1.04965907
57	MP0001764_abnormal_homeostasis	1.04732072
58	MP0005000_abnormal_immune_tolerance	1.04416549
59	MP0005025_abnormal_response_to	1.03893110
60	MP0008004_abnormal_stomach_pH	1.03883629
61	MP0009764_decreased_sensitivity_to	1.01753385
62	MP0008789_abnormal_olfactory_epithelium	1.01692779
63	MP0005266_abnormal_metabolism	1.00937001
64	MP0004381_abnormal_hair_follicle	1.00932564
65	MP0001188_hyperpigmentation	1.00506842
66	MP0003866_abnormal_defecation	0.98477716
67	MP0009840_abnormal_foam_cell	0.98250883
68	MP0001790_abnormal_immune_system	0.95541442
69	MP0005387_immune_system_phenotype	0.95541442
70	MP0000371_diluted_coat_color	0.95228633
71	MP0005083_abnormal_biliary_tract	0.95144188
72	MP0001529_abnormal_vocalization	0.94024265
73	MP0003698_abnormal_male_reproductive	0.93978203
74	MP0002928_abnormal_bile_duct	0.90445572
75	MP0003195_calcinosis	0.90264587
76	MP0002332_abnormal_exercise_endurance	0.88870111
77	MP0001501_abnormal_sleep_pattern	0.88787407
78	MP0001270_distended_abdomen	0.88464430
79	MP0001986_abnormal_taste_sensitivity	0.88270402
80	MP0009785_altered_susceptibility_to	0.87428624
81	MP0002229_neurodegeneration	0.87378219
82	MP0000716_abnormal_immune_system	0.86487516
83	MP0002419_abnormal_innate_immunity	0.84731808
84	MP0001486_abnormal_startle_reflex	0.83830054
85	MP0002277_abnormal_respiratory_mucosa	0.82625669
86	MP0002876_abnormal_thyroid_physiology	0.81099796
87	MP0000230_abnormal_systemic_arterial	0.80597786
88	MP0001502_abnormal_circadian_rhythm	0.80504164
89	MP0002405_respiratory_system_inflammati	0.78409874
90	MP0001929_abnormal_gametogenesis	0.78150091
91	MP0000689_abnormal_spleen_morphology	0.77907386
92	MP0001765_abnormal_ion_homeostasis	0.76955380
93	MP0001905_abnormal_dopamine_level	0.76249620
94	MP0005647_abnormal_sex_gland	0.73715148
95	MP0003122_maternal_imprinting	0.73082300
96	MP0002752_abnormal_somatic_nervous	0.72579384
97	MP0000631_abnormal_neuroendocrine_gland	0.71898171
98	MP0002938_white_spotting	0.71831146
99	MP0002398_abnormal_bone_marrow	0.71249068
100	MP0000427_abnormal_hair_cycle	0.71178505

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.58249349
2	Pancreatic fibrosis (HP:0100732)	3.57505039
3	Chronic hepatic failure (HP:0100626)	3.43026460
4	Cystic liver disease (HP:0006706)	3.41934383
5	Abnormality of DNA repair (HP:0003254)	3.23224283
6	Nephronophthisis (HP:0000090)	3.22558381
7	Tubulointerstitial nephritis (HP:0001970)	3.20403324
8	Abnormality of midbrain morphology (HP:0002418)	3.08950089
9	Molar tooth sign on MRI (HP:0002419)	3.08950089
10	Abnormality of the renal cortex (HP:0011035)	3.07991612
11	Abnormality of the columella (HP:0009929)	3.07690305
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.97682993
13	True hermaphroditism (HP:0010459)	2.93262827
14	Medial flaring of the eyebrow (HP:0010747)	2.91911619
15	Abnormality of the renal medulla (HP:0100957)	2.81281227
16	Severe combined immunodeficiency (HP:0004430)	2.80836748
17	Abnormal ciliary motility (HP:0012262)	2.78967144
18	Thyroiditis (HP:0100646)	2.78202324
19	Progressive cerebellar ataxia (HP:0002073)	2.77608209
20	Duplicated collecting system (HP:0000081)	2.75124845
21	Abnormality of the renal collecting system (HP:0004742)	2.73402414
22	Renal cortical cysts (HP:0000803)	2.71856611
23	Abnormality of lateral ventricle (HP:0030047)	2.63549164
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.56520402
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.53331245
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.53331245
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.51601537
28	Absent/shortened dynein arms (HP:0200106)	2.51601537
29	Cerebellar dysplasia (HP:0007033)	2.45947151
30	Abnormal drinking behavior (HP:0030082)	2.42557066
31	Polydipsia (HP:0001959)	2.42557066
32	Abnormality of eosinophils (HP:0001879)	2.28994905
33	Panhypogammaglobulinemia (HP:0003139)	2.27789604
34	Nephrogenic diabetes insipidus (HP:0009806)	2.24450860
35	Hepatocellular necrosis (HP:0001404)	2.21791577
36	Congenital primary aphakia (HP:0007707)	2.19431162
37	Tented upper lip vermilion (HP:0010804)	2.18656963
38	Clumsiness (HP:0002312)	2.16096028
39	Bile duct proliferation (HP:0001408)	2.15363061
40	Abnormal biliary tract physiology (HP:0012439)	2.15363061
41	Congenital stationary night blindness (HP:0007642)	2.12543030
42	Enlarged kidneys (HP:0000105)	2.11627979
43	Metaphyseal dysplasia (HP:0100255)	2.11478935
44	Attenuation of retinal blood vessels (HP:0007843)	2.10754655
45	Retrobulbar optic neuritis (HP:0100654)	2.10605603
46	Optic neuritis (HP:0100653)	2.10605603
47	Ketosis (HP:0001946)	2.10144118
48	Abnormal respiratory motile cilium physiology (HP:0012261)	2.10000556
49	Congenital hepatic fibrosis (HP:0002612)	2.08788190
50	Gait imbalance (HP:0002141)	2.08636484
51	Poor coordination (HP:0002370)	2.03911934
52	Occipital encephalocele (HP:0002085)	1.97700791
53	Inability to walk (HP:0002540)	1.95466735
54	Febrile seizures (HP:0002373)	1.94223289
55	Elevated erythrocyte sedimentation rate (HP:0003565)	1.93908256
56	Abolished electroretinogram (ERG) (HP:0000550)	1.93553399
57	Type II lissencephaly (HP:0007260)	1.93543269
58	Progressive microcephaly (HP:0000253)	1.91356459
59	Tubular atrophy (HP:0000092)	1.89120087
60	Retinal dysplasia (HP:0007973)	1.87318861
61	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.87264012
62	IgG deficiency (HP:0004315)	1.86346333
63	Absent thumb (HP:0009777)	1.86318155
64	Combined immunodeficiency (HP:0005387)	1.86035570
65	Abnormal mitochondria in muscle tissue (HP:0008316)	1.85543525
66	Abnormality of B cell number (HP:0010975)	1.83313211
67	Genital tract atresia (HP:0001827)	1.83199342
68	Polyuria (HP:0000103)	1.82955338
69	Recurrent fungal infections (HP:0002841)	1.82339581
70	Gaze-evoked nystagmus (HP:0000640)	1.81287129
71	Postaxial foot polydactyly (HP:0001830)	1.81148694
72	Median cleft lip (HP:0000161)	1.81078528
73	Chromsome breakage (HP:0040012)	1.80638658
74	Anencephaly (HP:0002323)	1.78976382
75	Stomach cancer (HP:0012126)	1.78306806
76	Recurrent cutaneous fungal infections (HP:0011370)	1.75065457
77	Chronic mucocutaneous candidiasis (HP:0002728)	1.75065457
78	Colitis (HP:0002583)	1.74488110
79	Keratitis (HP:0000491)	1.71717473
80	Bulbous nose (HP:0000414)	1.71258852
81	Tubulointerstitial abnormality (HP:0001969)	1.70930982
82	Hepatic necrosis (HP:0002605)	1.70815736
83	Stomatitis (HP:0010280)	1.70532554
84	Ulnar claw (HP:0001178)	1.68838805
85	Decreased central vision (HP:0007663)	1.67739418
86	Retinitis pigmentosa (HP:0000510)	1.67737196
87	Dicarboxylic aciduria (HP:0003215)	1.67341269
88	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.67341269
89	Pachygyria (HP:0001302)	1.67165267
90	Large for gestational age (HP:0001520)	1.66190803
91	Abnormal glycosylation (HP:0012345)	1.66093684
92	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.66093684
93	Abnormal protein N-linked glycosylation (HP:0012347)	1.66093684
94	Abnormal protein glycosylation (HP:0012346)	1.66093684
95	Myositis (HP:0100614)	1.65296274
96	Vaginal atresia (HP:0000148)	1.62594396
97	Broad-based gait (HP:0002136)	1.61756942
98	Microvesicular hepatic steatosis (HP:0001414)	1.61258803
99	Rib fusion (HP:0000902)	1.61052661
100	Hypoplastic iliac wings (HP:0002866)	1.61034746

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.66870444
2	FRK	3.46452722
3	MAP4K2	3.13867832
4	TAOK3	3.01775413
5	MARK3	2.80470573
6	MAP4K1	2.53380514
7	TXK	2.33689482
8	ZAK	2.25106759
9	AKT3	2.04021028
10	OBSCN	2.00045735
11	MAP3K7	1.80172160
12	BTK	1.65871960
13	MAPK15	1.64532404
14	MAP2K7	1.59369674
15	GRK1	1.51179381
16	MAP3K4	1.47864464
17	IKBKE	1.46509201
18	WNK4	1.43137809
19	ADRBK2	1.42122301
20	IKBKB	1.41927813
21	TNK2	1.40259177
22	INSRR	1.39923910
23	MAP3K11	1.37071428
24	MAPK13	1.36250016
25	GRK6	1.32791946
26	SGK494	1.30889464
27	SGK223	1.30889464
28	FES	1.26797523
29	SGK2	1.24454489
30	ITK	1.19294060
31	BLK	1.19140774
32	SIK2	1.15355083
33	PRKCQ	1.10419679
34	MAP3K13	1.09903690
35	SYK	1.08021180
36	BMPR1B	1.05816467
37	KIT	1.05757868
38	STK38	1.05388130
39	TBK1	1.04920921
40	TIE1	1.02315521
41	FGFR2	1.01860330
42	NUAK1	1.01485749
43	PTK2B	0.98296501
44	TLK1	0.96703365
45	TEC	0.92507970
46	CSNK1A1L	0.90132737
47	PIK3CA	0.88973713
48	MAP2K4	0.87533859
49	WNK3	0.87056868
50	MATK	0.86616839
51	MAPKAPK3	0.81734352
52	MAPK11	0.79859514
53	DYRK1B	0.77871626
54	LCK	0.77826307
55	JAK3	0.75568763
56	PAK3	0.75546399
57	PRKD2	0.72760431
58	GRK7	0.70447387
59	CAMK1	0.70346178
60	CSNK1G3	0.69434935
61	OXSR1	0.68681523
62	MAPK12	0.63690002
63	ACVR1B	0.63687724
64	PDK2	0.62162896
65	EPHA3	0.61764095
66	SGK3	0.61594097
67	PRKAA2	0.60706810
68	NEK2	0.59630428
69	PIK3CG	0.59565997
70	CAMK4	0.57780620
71	CDK8	0.57556747
72	CSNK1G1	0.57280250
73	MAPK7	0.56975833
74	LYN	0.56917045
75	MYLK	0.56364584
76	CAMKK2	0.56107963
77	PRKAA1	0.55785055
78	TYK2	0.54032392
79	NTRK2	0.53681167
80	MARK2	0.53543604
81	CHUK	0.52829620
82	RPS6KA6	0.51966115
83	KDR	0.51543754
84	MAP3K14	0.50573769
85	NLK	0.50485293
86	CSF1R	0.50270091
87	BCKDK	0.49652657
88	CDK3	0.49415342
89	ATR	0.49177652
90	FGR	0.47005952
91	DYRK3	0.46983601
92	MAP2K2	0.46593422
93	ZAP70	0.46200707
94	HCK	0.45955155
95	JAK1	0.43361533
96	RPS6KC1	0.42359935
97	RPS6KL1	0.42359935
98	CDC42BPA	0.40958399
99	CSNK1A1	0.39081060
100	MAP2K6	0.39017557

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	2.97823187
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.92941061
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.92567691
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.49771850
5	Butanoate metabolism_Homo sapiens_hsa00650	2.43912596
6	Phototransduction_Homo sapiens_hsa04744	2.40729235
7	Olfactory transduction_Homo sapiens_hsa04740	2.09217773
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.09211581
9	ABC transporters_Homo sapiens_hsa02010	2.08618231
10	Allograft rejection_Homo sapiens_hsa05330	2.02093246
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.00074087
12	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.98689726
13	Other glycan degradation_Homo sapiens_hsa00511	1.97218206
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.96689343
15	Regulation of autophagy_Homo sapiens_hsa04140	1.96390547
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.85431654
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.75306492
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71807003
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.71783785
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.71623231
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.60499573
22	Asthma_Homo sapiens_hsa05310	1.58312102
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.53519219
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.44339464
25	Homologous recombination_Homo sapiens_hsa03440	1.43530472
26	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.39686821
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.34109620
28	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.33502895
29	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.32745570
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.32383240
31	Peroxisome_Homo sapiens_hsa04146	1.29616403
32	Circadian rhythm_Homo sapiens_hsa04710	1.28944556
33	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.21920100
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.17130691
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.14845546
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12824735
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10153814
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09934530
39	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.09503602
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04091087
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03211316
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.00858186
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.00282561
44	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.98723750
45	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.96577731
46	Taste transduction_Homo sapiens_hsa04742	0.93766578
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88747282
48	Leishmaniasis_Homo sapiens_hsa05140	0.88288981
49	Osteoclast differentiation_Homo sapiens_hsa04380	0.87102486
50	Herpes simplex infection_Homo sapiens_hsa05168	0.86459785
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.83580539
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81259966
53	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.77605967
54	Tuberculosis_Homo sapiens_hsa05152	0.74812479
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73832597
56	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.72658338
57	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.72486844
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70940315
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.70722524
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.69877194
61	RNA degradation_Homo sapiens_hsa03018	0.68628444
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.67932301
63	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.67876788
64	Salivary secretion_Homo sapiens_hsa04970	0.65756520
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65613728
66	Lysine degradation_Homo sapiens_hsa00310	0.65249253
67	Sulfur relay system_Homo sapiens_hsa04122	0.64470322
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62766771
69	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.62161314
70	Measles_Homo sapiens_hsa05162	0.59492958
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58481284
72	Lysosome_Homo sapiens_hsa04142	0.57806087
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54791276
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.53779559
75	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.53753812
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.53444676
77	Retinol metabolism_Homo sapiens_hsa00830	0.52358813
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.51931301
79	Mineral absorption_Homo sapiens_hsa04978	0.51167983
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.50896784
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.50840334
82	Renin secretion_Homo sapiens_hsa04924	0.49326735
83	Influenza A_Homo sapiens_hsa05164	0.48315191
84	Fatty acid degradation_Homo sapiens_hsa00071	0.46819500
85	Legionellosis_Homo sapiens_hsa05134	0.46451579
86	Circadian entrainment_Homo sapiens_hsa04713	0.46353188
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45999669
88	Type II diabetes mellitus_Homo sapiens_hsa04930	0.45141557
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42507805
90	Phagosome_Homo sapiens_hsa04145	0.42395411
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.40317290
92	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.40068066
93	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.39727341
94	Insulin resistance_Homo sapiens_hsa04931	0.38806305
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38710346
96	Oxidative phosphorylation_Homo sapiens_hsa00190	0.38612451
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.38579181
98	RNA polymerase_Homo sapiens_hsa03020	0.38012638
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34644713
100	Propanoate metabolism_Homo sapiens_hsa00640	0.33842369

SDHAP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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