SDHAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)4.95732160
2Arp2/3 complex-mediated actin nucleation (GO:0034314)4.58424278
3positive regulation of gamma-delta T cell activation (GO:0046645)4.52123677
4dosage compensation (GO:0007549)4.18347312
5regulation of gamma-delta T cell activation (GO:0046643)3.94999379
6cell wall macromolecule metabolic process (GO:0044036)3.90032295
7regulation of gamma-delta T cell differentiation (GO:0045586)3.85996534
8cellular response to interleukin-15 (GO:0071350)3.85284869
9response to muramyl dipeptide (GO:0032495)3.84936659
10actin nucleation (GO:0045010)3.69723088
11histone H3-K36 demethylation (GO:0070544)3.61096570
12interferon-gamma production (GO:0032609)3.55791141
13negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.44354754
14response to interleukin-15 (GO:0070672)3.32089235
15regulation of B cell receptor signaling pathway (GO:0050855)3.30005301
16negative thymic T cell selection (GO:0045060)3.27180367
17positive regulation of granulocyte differentiation (GO:0030854)3.15455358
18negative T cell selection (GO:0043383)3.15302207
19chaperone mediated protein folding requiring cofactor (GO:0051085)3.09487746
20positive T cell selection (GO:0043368)3.03526983
21fibroblast migration (GO:0010761)3.03445039
22positive regulation of B cell differentiation (GO:0045579)2.98132726
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97569557
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89905752
25T cell selection (GO:0045058)2.89255084
26protein targeting to Golgi (GO:0000042)2.88249081
27establishment of protein localization to Golgi (GO:0072600)2.88053796
28tolerance induction (GO:0002507)2.87750665
29pyrimidine dimer repair (GO:0006290)2.78736600
30positive thymic T cell selection (GO:0045059)2.78411256
31positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.73695806
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72315092
33negative regulation of cell killing (GO:0031342)2.72315092
34retrograde transport, vesicle recycling within Golgi (GO:0000301)2.67911515
35cellular response to ethanol (GO:0071361)2.65944025
36regulation of B cell differentiation (GO:0045577)2.65473740
37histone mRNA catabolic process (GO:0071044)2.63850993
38regulation of defense response to virus by host (GO:0050691)2.61466865
39response to peptidoglycan (GO:0032494)2.59005326
40positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57862637
41histone H3-K4 trimethylation (GO:0080182)2.54803437
42defense response to protozoan (GO:0042832)2.54112239
43regulation of translation in response to stress (GO:0043555)2.53430325
44NIK/NF-kappaB signaling (GO:0038061)2.53142681
45regulation of necroptotic process (GO:0060544)2.52158915
46response to protozoan (GO:0001562)2.51038095
47regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.50876310
48cellular extravasation (GO:0045123)2.49768303
49detection of molecule of bacterial origin (GO:0032490)2.48790022
50peptidyl-lysine trimethylation (GO:0018023)2.47546828
51Golgi transport vesicle coating (GO:0048200)2.46084047
52COPI coating of Golgi vesicle (GO:0048205)2.46084047
53regulation of alpha-beta T cell proliferation (GO:0046640)2.45904694
54histone demethylation (GO:0016577)2.45568755
55macrophage activation involved in immune response (GO:0002281)2.45346853
56regulation of response to interferon-gamma (GO:0060330)2.44520585
57germinal center formation (GO:0002467)2.43968560
58positive regulation of macrophage differentiation (GO:0045651)2.41087571
59histone lysine demethylation (GO:0070076)2.40849573
60regulation of interferon-beta production (GO:0032648)2.40436281
61hepatocyte apoptotic process (GO:0097284)2.40176732
62positive regulation of interleukin-2 production (GO:0032743)2.38217122
63thymic T cell selection (GO:0045061)2.37958133
64T cell migration (GO:0072678)2.37650873
65histone H3-K9 methylation (GO:0051567)2.37213473
66protein demethylation (GO:0006482)2.35443919
67protein dealkylation (GO:0008214)2.35443919
68Peyers patch development (GO:0048541)2.33116843
69mucosal-associated lymphoid tissue development (GO:0048537)2.33116843
70regulation of T cell tolerance induction (GO:0002664)2.32082203
71histone H3-K9 modification (GO:0061647)2.32039193
72negative regulation of necroptotic process (GO:0060546)2.31969278
73skeletal muscle adaptation (GO:0043501)2.31270686
74histone H3-K4 methylation (GO:0051568)2.31167605
75regulation of mitochondrial fission (GO:0090140)2.30438022
76neutrophil activation (GO:0042119)2.30372579
77regulation of type I interferon-mediated signaling pathway (GO:0060338)2.30160305
78regulation of histone H3-K27 methylation (GO:0061085)2.30087322
79negative regulation of interleukin-12 production (GO:0032695)2.29707269
80regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.29488292
81positive regulation of defense response to virus by host (GO:0002230)2.27202660
82base-excision repair, AP site formation (GO:0006285)2.26343542
83protein K11-linked deubiquitination (GO:0035871)2.25899059
84RNA destabilization (GO:0050779)2.25793970
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.25192324
86granulocyte activation (GO:0036230)2.25119536
87positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.25070135
88CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.24854648
89T-helper cell differentiation (GO:0042093)2.24854648
90N-terminal protein amino acid acetylation (GO:0006474)2.24661301
91positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.23875834
92mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.23859529
93positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.23859529
94intra-Golgi vesicle-mediated transport (GO:0006891)2.22921882
95definitive hemopoiesis (GO:0060216)2.22791343
96regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.22779636
97regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.19880881
98negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.19603752
99neutrophil mediated immunity (GO:0002446)2.17868425
100I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.17368492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.04876523
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.81364392
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.17249909
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.13565774
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.12976710
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02917526
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97385370
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.84595188
9CIITA_25753668_ChIP-Seq_RAJI_Human2.69790205
10SCL_19346495_ChIP-Seq_HPC-7_Human2.49403022
11MYB_26560356_Chip-Seq_TH2_Human2.44065300
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30526141
13ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.25804403
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.20850865
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09686384
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08694509
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08628216
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.08006686
19RUNX_20019798_ChIP-Seq_JUKART_Human2.07734096
20SPI1_23547873_ChIP-Seq_NB4_Human2.07100563
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03433397
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01866732
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01738979
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00895523
25MYB_26560356_Chip-Seq_TH1_Human1.98243860
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98009281
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97994299
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81264875
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78909762
30VDR_23849224_ChIP-Seq_CD4+_Human1.78267391
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77399056
32SPI1_23127762_ChIP-Seq_K562_Human1.72761559
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.72434229
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70479861
35MYC_22102868_ChIP-Seq_BL_Human1.70264827
36TFEB_21752829_ChIP-Seq_HELA_Human1.69786080
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.69529169
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68847023
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68126303
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66913849
41FOXP3_21729870_ChIP-Seq_TREG_Human1.64652264
42GATA3_27048872_Chip-Seq_THYMUS_Human1.63705451
43UTX_26944678_Chip-Seq_JUKART_Human1.62923167
44MAF_26560356_Chip-Seq_TH1_Human1.62449185
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60688980
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52923039
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52504552
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.51227362
49GABP_19822575_ChIP-Seq_HepG2_Human1.48247509
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47584925
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46133745
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.45981253
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42856735
54MAF_26560356_Chip-Seq_TH2_Human1.42393857
55DCP1A_22483619_ChIP-Seq_HELA_Human1.41691902
56VDR_21846776_ChIP-Seq_THP-1_Human1.38653947
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.38377117
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36032305
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34557453
60GATA3_26560356_Chip-Seq_TH2_Human1.33700085
61* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33654022
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32023828
63IGF1R_20145208_ChIP-Seq_DFB_Human1.30615524
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.27966416
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27671482
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25568392
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24830337
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23675075
69E2F7_22180533_ChIP-Seq_HELA_Human1.23659563
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23317146
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23227761
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.22472873
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21590771
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21238729
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17813253
76KDM5A_27292631_Chip-Seq_BREAST_Human1.17321578
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15591504
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14985804
79TCF7_22412390_ChIP-Seq_EML_Mouse1.13989094
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10941556
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.08208583
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07691346
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07217818
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05789655
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05777720
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05761390
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05603878
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04379667
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04209812
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02795949
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.02783972
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02140246
93NCOR1_26117541_ChIP-Seq_K562_Human1.01141998
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01116229
95PU_27001747_Chip-Seq_BMDM_Mouse1.00666574
96PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98440234
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97264133
98ELK1_19687146_ChIP-ChIP_HELA_Human0.96755102
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96746560
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96659991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.95460531
2MP0003763_abnormal_thymus_physiology2.73719456
3MP0003656_abnormal_erythrocyte_physiolo2.72489720
4MP0000465_gastrointestinal_hemorrhage2.65154832
5MP0008260_abnormal_autophagy2.59493942
6MP0005671_abnormal_response_to2.42587909
7MP0002332_abnormal_exercise_endurance2.35865637
8MP0005451_abnormal_body_composition2.34965361
9MP0003724_increased_susceptibility_to2.33660441
10MP0003436_decreased_susceptibility_to2.24064766
11MP0004147_increased_porphyrin_level2.22745009
12MP0005000_abnormal_immune_tolerance1.97751405
13MP0003303_peritoneal_inflammation1.93064606
14MP0002419_abnormal_innate_immunity1.92800185
15MP0001800_abnormal_humoral_immune1.91932251
16MP0002452_abnormal_antigen_presenting1.83006273
17MP0001819_abnormal_immune_cell1.82260664
18MP0006054_spinal_hemorrhage1.82047644
19MP0002420_abnormal_adaptive_immunity1.81172967
20MP0002723_abnormal_immune_serum1.80872218
21MP0003646_muscle_fatigue1.79207361
22MP0002398_abnormal_bone_marrow1.73010473
23MP0004947_skin_inflammation1.69821599
24MP0005025_abnormal_response_to1.68894216
25MP0003950_abnormal_plasma_membrane1.67577203
26MP0000751_myopathy1.67370548
27MP0000689_abnormal_spleen_morphology1.64874770
28MP0003221_abnormal_cardiomyocyte_apopto1.62690903
29MP0003172_abnormal_lysosome_physiology1.60195717
30MP0002722_abnormal_immune_system1.58596308
31MP0005058_abnormal_lysosome_morphology1.56608959
32MP0000716_abnormal_immune_system1.55169346
33MP0001545_abnormal_hematopoietic_system1.53855168
34MP0005397_hematopoietic_system_phenotyp1.53855168
35MP0000372_irregular_coat_pigmentation1.53552388
36MP0005075_abnormal_melanosome_morpholog1.53368380
37MP0000749_muscle_degeneration1.50156720
38MP0003866_abnormal_defecation1.49636660
39MP0008057_abnormal_DNA_replication1.46433833
40MP0000703_abnormal_thymus_morphology1.45746894
41MP0001790_abnormal_immune_system1.45009207
42MP0005387_immune_system_phenotype1.45009207
43MP0009278_abnormal_bone_marrow1.41263041
44MP0002405_respiratory_system_inflammati1.39382615
45MP0001853_heart_inflammation1.38258146
46MP0009785_altered_susceptibility_to1.36492638
47MP0008058_abnormal_DNA_repair1.34230201
48MP0002429_abnormal_blood_cell1.33901264
49MP0010155_abnormal_intestine_physiology1.30885011
50MP0003786_premature_aging1.30616086
51MP0004233_abnormal_muscle_weight1.29421976
52MP0002009_preneoplasia1.26429199
53MP0010094_abnormal_chromosome_stability1.24944779
54MP0002396_abnormal_hematopoietic_system1.24437644
55MP0002019_abnormal_tumor_incidence1.23091371
56MP0002148_abnormal_hypersensitivity_rea1.22414936
57MP0003806_abnormal_nucleotide_metabolis1.20332161
58MP0002269_muscular_atrophy1.19031146
59MP0000685_abnormal_immune_system1.17162092
60MP0010307_abnormal_tumor_latency1.16317512
61MP0002166_altered_tumor_susceptibility1.15648155
62MP0009333_abnormal_splenocyte_physiolog1.15544123
63MP0001845_abnormal_inflammatory_respons1.15328408
64MP0005167_abnormal_blood-brain_barrier1.13674289
65MP0005464_abnormal_platelet_physiology1.13325440
66MP0008007_abnormal_cellular_replicative1.12637859
67MP0005266_abnormal_metabolism1.11061381
68MP0006082_CNS_inflammation1.09397723
69MP0000371_diluted_coat_color1.07912051
70MP0008995_early_reproductive_senescence1.07890601
71MP0003300_gastrointestinal_ulcer1.07049910
72MP0000015_abnormal_ear_pigmentation1.05508980
73MP0005076_abnormal_cell_differentiation1.03002086
74MP0006035_abnormal_mitochondrial_morpho1.00341213
75MP0003183_abnormal_peptide_metabolism0.95635714
76MP0001533_abnormal_skeleton_physiology0.95567683
77MP0005083_abnormal_biliary_tract0.92687925
78MP0005310_abnormal_salivary_gland0.92449603
79MP0001243_abnormal_dermal_layer0.90791877
80MP0002102_abnormal_ear_morphology0.90163494
81MP0003045_fibrosis0.89644731
82MP0000858_altered_metastatic_potential0.87899171
83MP0004145_abnormal_muscle_electrophysio0.87437082
84MP0003111_abnormal_nucleus_morphology0.86022938
85MP0003828_pulmonary_edema0.85376996
86MP0001727_abnormal_embryo_implantation0.84597565
87MP0005621_abnormal_cell_physiology0.84585901
88MP0002933_joint_inflammation0.83944813
89MP0000358_abnormal_cell_content/0.82626295
90MP0004381_abnormal_hair_follicle0.82357089
91MP0009763_increased_sensitivity_to0.81714319
92MP0002998_abnormal_bone_remodeling0.80299079
93MP0001661_extended_life_span0.79400437
94MP0008469_abnormal_protein_level0.79359728
95MP0001873_stomach_inflammation0.78982321
96MP0001851_eye_inflammation0.75669283
97MP0003795_abnormal_bone_structure0.73625326
98MP0000569_abnormal_digit_pigmentation0.73363474
99MP0000759_abnormal_skeletal_muscle0.72918788
100MP0009765_abnormal_xenobiotic_induced0.72851547

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)3.49665556
2Cholecystitis (HP:0001082)3.29151005
3Abnormal gallbladder physiology (HP:0012438)3.29151005
4Combined immunodeficiency (HP:0005387)3.10086541
5Granulocytopenia (HP:0001913)2.97544292
6Acute hepatic failure (HP:0006554)2.92506203
7Recurrent fungal infections (HP:0002841)2.90232178
8Exercise-induced myalgia (HP:0003738)2.87434837
9Loss of speech (HP:0002371)2.79982887
10Panhypogammaglobulinemia (HP:0003139)2.67649678
11Stomatitis (HP:0010280)2.66782365
12Colitis (HP:0002583)2.62179555
13Myositis (HP:0100614)2.61992274
14Recurrent cutaneous fungal infections (HP:0011370)2.61497284
15Chronic mucocutaneous candidiasis (HP:0002728)2.61497284
16Duplicated collecting system (HP:0000081)2.59508397
17Neonatal respiratory distress (HP:0002643)2.59066108
18Broad face (HP:0000283)2.58623591
19Abnormality of the columella (HP:0009929)2.55967405
20Abnormality of eosinophils (HP:0001879)2.53091323
21T lymphocytopenia (HP:0005403)2.49840059
22Eczematoid dermatitis (HP:0000976)2.47039967
23Elevated erythrocyte sedimentation rate (HP:0003565)2.45548317
24Increased connective tissue (HP:0009025)2.43620052
25Microvesicular hepatic steatosis (HP:0001414)2.43618425
26Recurrent abscess formation (HP:0002722)2.43100713
27Increased serum ferritin (HP:0003281)2.41695936
28Distal lower limb amyotrophy (HP:0008944)2.40547964
29Leukocytosis (HP:0001974)2.39530282
30Recurrent bacterial skin infections (HP:0005406)2.36738205
31Ureteral obstruction (HP:0006000)2.36151720
32Keratitis (HP:0000491)2.31328007
33Nemaline bodies (HP:0003798)2.31168493
34Abnormality of T cell number (HP:0011839)2.30716480
35Long clavicles (HP:0000890)2.29544732
36Entropion (HP:0000621)2.28041315
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.27613218
38Ureteral stenosis (HP:0000071)2.26447334
39Cerebral palsy (HP:0100021)2.23850577
40Abnormality of the renal collecting system (HP:0004742)2.23528838
41Fatigue (HP:0012378)2.22162469
42Eosinophilia (HP:0001880)2.22096762
43Myopathic facies (HP:0002058)2.21848419
44Retrobulbar optic neuritis (HP:0100654)2.20235586
45Optic neuritis (HP:0100653)2.20235586
46Hemoptysis (HP:0002105)2.20180466
47Abnormality of iron homeostasis (HP:0011031)2.19921746
48Amyotrophic lateral sclerosis (HP:0007354)2.19532406
49Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.18179921
50Poikiloderma (HP:0001029)2.16973957
51Ectropion (HP:0000656)2.16835794
52Thyroiditis (HP:0100646)2.16832732
53Rimmed vacuoles (HP:0003805)2.16829473
54Pustule (HP:0200039)2.16158913
55Muscle fiber inclusion bodies (HP:0100299)2.15159084
56Autoimmune thrombocytopenia (HP:0001973)2.12078251
57IgG deficiency (HP:0004315)2.11501442
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.10789553
59Abnormal protein N-linked glycosylation (HP:0012347)2.09570483
60Abnormal protein glycosylation (HP:0012346)2.09570483
61Abnormal glycosylation (HP:0012345)2.09570483
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09570483
63Abnormality of DNA repair (HP:0003254)2.08593754
64Rhabdomyolysis (HP:0003201)2.06379378
65Recurrent viral infections (HP:0004429)2.05876004
66Abnormality of transition element cation homeostasis (HP:0011030)2.03785455
67Chest pain (HP:0100749)2.01766834
68Abnormality of the prostate (HP:0008775)2.01417571
69Chronic diarrhea (HP:0002028)2.01289994
70Abnormality of the pleura (HP:0002103)2.00420172
71Vacuolated lymphocytes (HP:0001922)2.00411454
72Tubulointerstitial nephritis (HP:0001970)1.99226500
73Atrophy/Degeneration involving motor neurons (HP:0007373)1.97072099
74Abnormality of macrophages (HP:0004311)1.96584224
75Tented upper lip vermilion (HP:0010804)1.96249217
76Abnormality of the fingertips (HP:0001211)1.96192129
77Mediastinal lymphadenopathy (HP:0100721)1.95980742
78Orchitis (HP:0100796)1.95923598
79Multiple enchondromatosis (HP:0005701)1.92454983
80Encephalitis (HP:0002383)1.92214425
81Increased cerebral lipofuscin (HP:0011813)1.91684602
82Meningitis (HP:0001287)1.91315437
83Abnormality of T cells (HP:0002843)1.91073503
84Ureteral duplication (HP:0000073)1.90837731
85Abnormality of pyrimidine metabolism (HP:0004353)1.90055771
86Pulmonary infiltrates (HP:0002113)1.87008677
87Renal cortical cysts (HP:0000803)1.86936673
88Pelvic girdle muscle weakness (HP:0003749)1.86123497
89Recurrent skin infections (HP:0001581)1.86099761
90Hypoplasia of the thymus (HP:0000778)1.85790445
91Spinal muscular atrophy (HP:0007269)1.84950845
92Interstitial pulmonary disease (HP:0006530)1.83802701
93Progressive microcephaly (HP:0000253)1.82404352
94Inflammation of the large intestine (HP:0002037)1.81362043
95Facial diplegia (HP:0001349)1.79618608
96Prominent nose (HP:0000448)1.76426238
97Abnormality of the musculature of the pelvis (HP:0001469)1.74615155
98Abnormality of the hip-girdle musculature (HP:0001445)1.74615155
99Autoimmune hemolytic anemia (HP:0001890)1.73967826
100Myoglobinuria (HP:0002913)1.73253051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.77194198
2SCYL23.39359576
3MAP4K13.27513591
4MAP3K142.40670837
5TESK22.35709200
6SIK32.34990291
7BLK2.03740889
8TBK11.89372855
9GRK61.88917332
10MAP2K31.87907727
11JAK31.87671352
12MAP4K21.85482472
13GRK71.84904060
14BRD41.77972768
15BCR1.64055706
16EIF2AK31.62100460
17MST1R1.58372442
18TRIM281.55992870
19EPHA31.55874702
20ZAP701.54219673
21SRPK11.49857373
22TGFBR21.48978193
23JAK11.48265817
24SIK21.47043268
25IKBKE1.44784257
26STK101.42562249
27TYK21.40729337
28PKN21.40170959
29BTK1.38653796
30BCKDK1.38340773
31OBSCN1.34344983
32KIT1.33626647
33MAP3K71.32512037
34FLT31.31621236
35MATK1.27624883
36TTN1.25861176
37CSF1R1.22505639
38PDK21.21882914
39ITK1.17646343
40PBK1.16219186
41IKBKB1.14595631
42TAOK31.11407552
43TNK21.10893056
44CDK121.10060232
45SYK1.09806371
46MARK31.08525080
47FES1.07805496
48ERBB31.01227612
49KDR0.97559018
50HCK0.95602459
51LCK0.95490310
52RIPK40.94005452
53PIK3CG0.92304985
54FGR0.89485233
55MAPKAPK30.89415734
56PIM20.88861340
57BMPR20.84413151
58ERN10.83164842
59TEC0.81057949
60EIF2AK10.80899262
61MAP3K60.80658326
62NUAK10.80600761
63JAK20.76483438
64BRSK20.75175410
65LYN0.68135265
66MAP2K40.67500479
67MAPK70.65781700
68RPS6KA40.64199991
69PRKD20.64193095
70MAP2K60.62504240
71CHUK0.62396028
72PRPF4B0.60088150
73MAPK110.58655692
74ACVR1B0.58300646
75MOS0.58201154
76EPHB10.58009213
77AKT30.57423297
78EIF2AK20.57289470
79NEK90.57252048
80MAP3K30.56969371
81MAP3K110.53481576
82CAMKK20.51160311
83CLK10.49965730
84MAP2K70.47241259
85NME10.47079801
86ATR0.46887735
87IGF1R0.43197401
88MAP3K130.42351097
89MAP3K40.41276972
90MAPK30.41033767
91MAP2K20.40071073
92FGFR40.38967453
93PRKAA20.38644817
94EGFR0.38445706
95PIM10.38232177
96CSNK1A1L0.36195955
97RAF10.34709411
98ABL10.33905983
99CAMK40.33338878
100MTOR0.32897805

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.21781429
2Allograft rejection_Homo sapiens_hsa053302.36407914
3Non-homologous end-joining_Homo sapiens_hsa034502.32698454
4Graft-versus-host disease_Homo sapiens_hsa053322.20298243
5Autoimmune thyroid disease_Homo sapiens_hsa053202.12253304
6Leishmaniasis_Homo sapiens_hsa051402.05652074
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.04626321
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97344763
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.91423664
10Antigen processing and presentation_Homo sapiens_hsa046121.86961442
11Viral myocarditis_Homo sapiens_hsa054161.84061624
12Primary immunodeficiency_Homo sapiens_hsa053401.78418468
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.78350798
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77614610
15Herpes simplex infection_Homo sapiens_hsa051681.75780530
16Legionellosis_Homo sapiens_hsa051341.71052103
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.69535429
18Osteoclast differentiation_Homo sapiens_hsa043801.67488094
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57919585
20Type I diabetes mellitus_Homo sapiens_hsa049401.56094683
21Tuberculosis_Homo sapiens_hsa051521.55590265
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54414856
23Measles_Homo sapiens_hsa051621.53186774
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53152401
25Asthma_Homo sapiens_hsa053101.51234251
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49200885
27Influenza A_Homo sapiens_hsa051641.47429061
28Base excision repair_Homo sapiens_hsa034101.41173654
29TNF signaling pathway_Homo sapiens_hsa046681.39874080
30Staphylococcus aureus infection_Homo sapiens_hsa051501.39090032
31Fanconi anemia pathway_Homo sapiens_hsa034601.37722364
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.36894317
33Toxoplasmosis_Homo sapiens_hsa051451.34247418
34Acute myeloid leukemia_Homo sapiens_hsa052211.32800527
35Epstein-Barr virus infection_Homo sapiens_hsa051691.30736883
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30401347
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28270060
38Shigellosis_Homo sapiens_hsa051311.25140122
39Regulation of autophagy_Homo sapiens_hsa041401.23853792
40Hepatitis B_Homo sapiens_hsa051611.22458369
41Rheumatoid arthritis_Homo sapiens_hsa053231.22381210
42Lysosome_Homo sapiens_hsa041421.21971125
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20661708
44T cell receptor signaling pathway_Homo sapiens_hsa046601.20173887
45Fructose and mannose metabolism_Homo sapiens_hsa000511.08556444
46Salmonella infection_Homo sapiens_hsa051321.06915017
47Apoptosis_Homo sapiens_hsa042101.04853052
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03824199
49B cell receptor signaling pathway_Homo sapiens_hsa046620.99448701
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98640489
51Hematopoietic cell lineage_Homo sapiens_hsa046400.98093167
52Inositol phosphate metabolism_Homo sapiens_hsa005620.97258560
53Lysine degradation_Homo sapiens_hsa003100.96693601
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94994142
55RNA polymerase_Homo sapiens_hsa030200.94102217
56mTOR signaling pathway_Homo sapiens_hsa041500.91004069
57Pertussis_Homo sapiens_hsa051330.86397023
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85268136
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84108559
60Hepatitis C_Homo sapiens_hsa051600.84033955
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76873653
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75787289
63Circadian rhythm_Homo sapiens_hsa047100.75461149
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73596248
65Viral carcinogenesis_Homo sapiens_hsa052030.72183440
66Pentose phosphate pathway_Homo sapiens_hsa000300.71414786
67Phagosome_Homo sapiens_hsa041450.69814351
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69378352
69Platelet activation_Homo sapiens_hsa046110.68917895
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67638824
71RNA degradation_Homo sapiens_hsa030180.65524023
72Spliceosome_Homo sapiens_hsa030400.65521459
73Fatty acid elongation_Homo sapiens_hsa000620.62426585
74Non-small cell lung cancer_Homo sapiens_hsa052230.61248894
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59478109
76Insulin resistance_Homo sapiens_hsa049310.59078623
77Carbon metabolism_Homo sapiens_hsa012000.58427194
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58021854
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57821078
80HTLV-I infection_Homo sapiens_hsa051660.56888466
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54830224
82Basal transcription factors_Homo sapiens_hsa030220.53128654
83Pyrimidine metabolism_Homo sapiens_hsa002400.51614872
84N-Glycan biosynthesis_Homo sapiens_hsa005100.51414333
85RNA transport_Homo sapiens_hsa030130.51184262
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50237039
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48079360
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46076181
89Prolactin signaling pathway_Homo sapiens_hsa049170.45809575
90Vibrio cholerae infection_Homo sapiens_hsa051100.45231796
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44720330
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.44461758
93HIF-1 signaling pathway_Homo sapiens_hsa040660.42490658
94Chemokine signaling pathway_Homo sapiens_hsa040620.41934144
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.40905833
96mRNA surveillance pathway_Homo sapiens_hsa030150.40784290
97Peroxisome_Homo sapiens_hsa041460.40642723
98AMPK signaling pathway_Homo sapiens_hsa041520.40513186
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40499605
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40274171

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