ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ubiquinone biosynthetic process (GO:0006744)	4.67366387
2	ubiquinone metabolic process (GO:0006743)	4.42543360
3	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.04851370
4	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.04851370
5	protein K11-linked deubiquitination (GO:0035871)	3.83236146
6	DNA deamination (GO:0045006)	3.82964929
7	iron-sulfur cluster assembly (GO:0016226)	3.70981157
8	metallo-sulfur cluster assembly (GO:0031163)	3.70981157
9	rRNA modification (GO:0000154)	3.67344012
10	quinone biosynthetic process (GO:1901663)	3.66796162
11	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.53912845
12	DNA integration (GO:0015074)	3.51846852
13	cullin deneddylation (GO:0010388)	3.41209769
14	mannosylation (GO:0097502)	3.40315696
15	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.33853987
16	pyrimidine nucleobase catabolic process (GO:0006208)	3.30304640
17	histone H2A acetylation (GO:0043968)	3.20836194
18	protein deneddylation (GO:0000338)	3.20782430
19	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.17458898
20	NADH dehydrogenase complex assembly (GO:0010257)	3.14829534
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.14829534
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.14829534
23	mismatch repair (GO:0006298)	3.13832782
24	pyrimidine nucleotide catabolic process (GO:0006244)	3.10678305
25	replication fork processing (GO:0031297)	3.10253659
26	S-adenosylmethionine metabolic process (GO:0046500)	3.10112378
27	rRNA methylation (GO:0031167)	3.04628684
28	protein complex biogenesis (GO:0070271)	3.02440372
29	GPI anchor metabolic process (GO:0006505)	3.01871347
30	DNA double-strand break processing (GO:0000729)	3.00843223
31	preassembly of GPI anchor in ER membrane (GO:0016254)	2.99609242
32	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.98842174
33	seminiferous tubule development (GO:0072520)	2.96270568
34	adenosine metabolic process (GO:0046085)	2.93960013
35	GPI anchor biosynthetic process (GO:0006506)	2.93317561
36	cellular ketone body metabolic process (GO:0046950)	2.92447593
37	DNA ligation (GO:0006266)	2.92189194
38	axoneme assembly (GO:0035082)	2.90809474
39	mitochondrial respiratory chain complex assembly (GO:0033108)	2.88176361
40	mitochondrial RNA metabolic process (GO:0000959)	2.88147020
41	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.87988363
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.87988363
43	regulation of cilium movement (GO:0003352)	2.87113544
44	DNA demethylation (GO:0080111)	2.84774010
45	branched-chain amino acid catabolic process (GO:0009083)	2.82349307
46	nonmotile primary cilium assembly (GO:0035058)	2.82031131
47	succinate metabolic process (GO:0006105)	2.79522511
48	lymphoid progenitor cell differentiation (GO:0002320)	2.78933489
49	negative regulation by host of viral transcription (GO:0043922)	2.78287155
50	peptidyl-histidine modification (GO:0018202)	2.72943313
51	nucleobase catabolic process (GO:0046113)	2.71269900
52	DNA dealkylation (GO:0035510)	2.70720158
53	deoxyribose phosphate catabolic process (GO:0046386)	2.70558500
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.70138749
55	ketone body metabolic process (GO:1902224)	2.67715858
56	lysosome localization (GO:0032418)	2.67496093
57	deoxyribonucleotide catabolic process (GO:0009264)	2.66908787
58	mitochondrial DNA replication (GO:0006264)	2.65611011
59	base-excision repair, AP site formation (GO:0006285)	2.63555373
60	DNA catabolic process, exonucleolytic (GO:0000738)	2.63360122
61	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.62835222
62	spinal cord motor neuron differentiation (GO:0021522)	2.62185750
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.61038174
64	aggressive behavior (GO:0002118)	2.60039196
65	recombinational repair (GO:0000725)	2.59111631
66	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.58536411
67	post-embryonic morphogenesis (GO:0009886)	2.58523501
68	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.57105992
69	double-strand break repair via homologous recombination (GO:0000724)	2.56520704
70	negative regulation of B cell apoptotic process (GO:0002903)	2.55945407
71	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.53364236
72	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.52478537
73	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.52182297
74	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.50988780
75	piRNA metabolic process (GO:0034587)	2.50687142
76	tRNA processing (GO:0008033)	2.49250022
77	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.47517347
78	nucleobase biosynthetic process (GO:0046112)	2.47173959
79	establishment of mitochondrion localization (GO:0051654)	2.45768130
80	tRNA modification (GO:0006400)	2.44966283
81	mitochondrion transport along microtubule (GO:0047497)	2.44078567
82	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.44078567
83	quinone metabolic process (GO:1901661)	2.43577642
84	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.42028106
85	C-terminal protein lipidation (GO:0006501)	2.41352328
86	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.41273950
87	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.40609420
88	isotype switching (GO:0045190)	2.40609420
89	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.40609420
90	anterograde synaptic vesicle transport (GO:0048490)	2.40551330
91	positive regulation of prostaglandin secretion (GO:0032308)	2.39618031
92	centriole replication (GO:0007099)	2.39285140
93	cilium morphogenesis (GO:0060271)	2.39281362
94	branched-chain amino acid metabolic process (GO:0009081)	2.39020847
95	cytidine metabolic process (GO:0046087)	2.38203476
96	cytidine catabolic process (GO:0006216)	2.38203476
97	cytidine deamination (GO:0009972)	2.38203476
98	regulation of glucokinase activity (GO:0033131)	2.37299990
99	regulation of hexokinase activity (GO:1903299)	2.37299990
100	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.36640415

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.06859487
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.78746801
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.50330949
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.44245994
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.43988551
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.29708098
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.17631929
8	IGF1R_20145208_ChIP-Seq_DFB_Human	3.08484347
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.97687673
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.96191960
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.82878358
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.76062896
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.69435628
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.58822823
15	FOXP3_21729870_ChIP-Seq_TREG_Human	2.37366500
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.36949731
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.34370077
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.24322253
19	E2F7_22180533_ChIP-Seq_HELA_Human	2.23324656
20	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.19417619
21	GABP_19822575_ChIP-Seq_HepG2_Human	2.18492374
22	IRF1_19129219_ChIP-ChIP_H3396_Human	2.18400453
23	CIITA_25753668_ChIP-Seq_RAJI_Human	2.10169992
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.05814210
25	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.04212190
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.95974497
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.94247215
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.91310041
29	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.86138337
30	FUS_26573619_Chip-Seq_HEK293_Human	1.85621940
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.77172571
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74612530
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73338200
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.71177030
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.65081969
36	EWS_26573619_Chip-Seq_HEK293_Human	1.61135297
37	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.59583365
38	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.58320281
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.56945598
40	KDM5A_27292631_Chip-Seq_BREAST_Human	1.56637219
41	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.52353084
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.50801318
43	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.49681772
44	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.49658806
45	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.49632087
46	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.46745918
47	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.45805528
48	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.45101942
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.43727457
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43673471
51	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.40246769
52	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.38556589
53	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.38439035
54	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.29146513
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27918940
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.26775113
57	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.26295366
58	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.25773286
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.25197400
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.24881111
61	AR_20517297_ChIP-Seq_VCAP_Human	1.23508632
62	HTT_18923047_ChIP-ChIP_STHdh_Human	1.22987546
63	XRN2_22483619_ChIP-Seq_HELA_Human	1.21614695
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.19129659
65	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.18270858
66	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17153944
67	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16630513
68	TAF15_26573619_Chip-Seq_HEK293_Human	1.16081164
69	VDR_22108803_ChIP-Seq_LS180_Human	1.15385394
70	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.13760157
71	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.13548174
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13246500
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13246500
74	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.11958376
75	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.10801770
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10521899
77	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.09462702
78	TTF2_22483619_ChIP-Seq_HELA_Human	1.09042556
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.06723673
80	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.06627331
81	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.05156439
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.04597166
83	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.00503863
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98181321
85	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.97481460
86	P300_19829295_ChIP-Seq_ESCs_Human	0.97016633
87	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.93554053
88	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.90466726
89	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.89008205
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88173950
91	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.87666680
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87276603
93	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.86500964
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.85536387
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.85536387
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.84642800
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.83343336
98	MYB_26560356_Chip-Seq_TH2_Human	0.83236793
99	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.83113549
100	NCOR_22424771_ChIP-Seq_293T_Human	0.82877135

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	3.52507069
2	MP0003880_abnormal_central_pattern	3.37640398
3	MP0005075_abnormal_melanosome_morpholog	3.01611620
4	MP0002102_abnormal_ear_morphology	2.93322133
5	MP0006072_abnormal_retinal_apoptosis	2.66581272
6	MP0008007_abnormal_cellular_replicative	2.58580428
7	MP0002736_abnormal_nociception_after	2.33898512
8	MP0002653_abnormal_ependyma_morphology	2.33128150
9	MP0010094_abnormal_chromosome_stability	2.29077250
10	MP0006035_abnormal_mitochondrial_morpho	2.22242116
11	MP0001968_abnormal_touch/_nociception	2.17670018
12	MP0005551_abnormal_eye_electrophysiolog	2.08709638
13	MP0005253_abnormal_eye_physiology	2.08208049
14	MP0001919_abnormal_reproductive_system	1.91075368
15	MP0004147_increased_porphyrin_level	1.89883031
16	MP0003693_abnormal_embryo_hatching	1.79674087
17	MP0005646_abnormal_pituitary_gland	1.76895284
18	MP0008877_abnormal_DNA_methylation	1.72870144
19	MP0006276_abnormal_autonomic_nervous	1.68696456
20	MP0000569_abnormal_digit_pigmentation	1.68403137
21	MP0001529_abnormal_vocalization	1.67731160
22	MP0005423_abnormal_somatic_nervous	1.65315333
23	MP0006292_abnormal_olfactory_placode	1.65239355
24	MP0000631_abnormal_neuroendocrine_gland	1.65011713
25	MP0002234_abnormal_pharynx_morphology	1.61436437
26	MP0005671_abnormal_response_to	1.57523539
27	MP0000372_irregular_coat_pigmentation	1.57215744
28	MP0005645_abnormal_hypothalamus_physiol	1.56952074
29	MP0008789_abnormal_olfactory_epithelium	1.47173302
30	MP0003786_premature_aging	1.46869673
31	MP0002095_abnormal_skin_pigmentation	1.39632343
32	MP0005389_reproductive_system_phenotype	1.38330565
33	MP0005408_hypopigmentation	1.37671544
34	MP0008995_early_reproductive_senescence	1.36429728
35	MP0003111_abnormal_nucleus_morphology	1.35047518
36	MP0005367_renal/urinary_system_phenotyp	1.34895278
37	MP0000516_abnormal_urinary_system	1.34895278
38	MP0001764_abnormal_homeostasis	1.31624390
39	MP0002751_abnormal_autonomic_nervous	1.29267807
40	MP0003646_muscle_fatigue	1.28556654
41	MP0003763_abnormal_thymus_physiology	1.23640686
42	MP0009697_abnormal_copulation	1.23522993
43	MP0005391_vision/eye_phenotype	1.22658709
44	MP0000015_abnormal_ear_pigmentation	1.19601743
45	MP0001929_abnormal_gametogenesis	1.18314855
46	MP0002160_abnormal_reproductive_system	1.17175219
47	MP0006036_abnormal_mitochondrial_physio	1.15257867
48	MP0005394_taste/olfaction_phenotype	1.14221391
49	MP0005499_abnormal_olfactory_system	1.14221391
50	MP0003183_abnormal_peptide_metabolism	1.13698156
51	MP0003698_abnormal_male_reproductive	1.13528134
52	MP0005410_abnormal_fertilization	1.12386023
53	MP0001293_anophthalmia	1.10890449
54	MP0005174_abnormal_tail_pigmentation	1.09316148
55	MP0002638_abnormal_pupillary_reflex	1.05614135
56	MP0005084_abnormal_gallbladder_morpholo	1.00111631
57	MP0004133_heterotaxia	0.99797083
58	MP0002837_dystrophic_cardiac_calcinosis	0.99400037
59	MP0008875_abnormal_xenobiotic_pharmacok	0.97785218
60	MP0000358_abnormal_cell_content/	0.97314260
61	MP0000383_abnormal_hair_follicle	0.97304548
62	MP0008872_abnormal_physiological_respon	0.96939988
63	MP0003718_maternal_effect	0.96167411
64	MP0003195_calcinosis	0.93158067
65	MP0001324_abnormal_eye_pigmentation	0.92589582
66	MP0003136_yellow_coat_color	0.92305097
67	MP0001727_abnormal_embryo_implantation	0.91711447
68	MP0001145_abnormal_male_reproductive	0.91470250
69	MP0001119_abnormal_female_reproductive	0.90967673
70	MP0002210_abnormal_sex_determination	0.90837762
71	MP0001984_abnormal_olfaction	0.90539650
72	MP0005195_abnormal_posterior_eye	0.89363044
73	MP0004145_abnormal_muscle_electrophysio	0.87948036
74	MP0003172_abnormal_lysosome_physiology	0.87347005
75	MP0002254_reproductive_system_inflammat	0.87059705
76	MP0003077_abnormal_cell_cycle	0.86649490
77	MP0004742_abnormal_vestibular_system	0.85013440
78	MP0002090_abnormal_vision	0.84364951
79	MP0003221_abnormal_cardiomyocyte_apopto	0.83934811
80	MP0009046_muscle_twitch	0.83236427
81	MP0000653_abnormal_sex_gland	0.82958931
82	MP0001486_abnormal_startle_reflex	0.80869581
83	MP0001177_atelectasis	0.80835352
84	MP0002876_abnormal_thyroid_physiology	0.80333705
85	MP0008932_abnormal_embryonic_tissue	0.78613200
86	MP0002277_abnormal_respiratory_mucosa	0.77390609
87	MP0001986_abnormal_taste_sensitivity	0.76130640
88	MP0003011_delayed_dark_adaptation	0.75660395
89	MP0000703_abnormal_thymus_morphology	0.75369615
90	MP0002752_abnormal_somatic_nervous	0.73670739
91	MP0008057_abnormal_DNA_replication	0.72772366
92	MP0005332_abnormal_amino_acid	0.71713865
93	MP0001661_extended_life_span	0.71338714
94	MP0002019_abnormal_tumor_incidence	0.70412423
95	MP0002735_abnormal_chemical_nociception	0.69871108
96	MP0000689_abnormal_spleen_morphology	0.68579421
97	MP0002229_neurodegeneration	0.68118124
98	MP0005365_abnormal_bile_salt	0.68031095
99	MP0009764_decreased_sensitivity_to	0.67447111
100	MP0000371_diluted_coat_color	0.66432408

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	3.80644854
2	Hepatic necrosis (HP:0002605)	3.39048293
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.37546011
4	True hermaphroditism (HP:0010459)	3.36908570
5	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.26932889
6	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.26932889
7	Abnormality of B cell number (HP:0010975)	3.23425724
8	Type II lissencephaly (HP:0007260)	3.21148165
9	Increased CSF lactate (HP:0002490)	3.16455817
10	Mitochondrial inheritance (HP:0001427)	3.16377198
11	B lymphocytopenia (HP:0010976)	3.15804225
12	Abnormality of midbrain morphology (HP:0002418)	3.07306286
13	Molar tooth sign on MRI (HP:0002419)	3.07306286
14	Increased intramyocellular lipid droplets (HP:0012240)	3.06702988
15	IgM deficiency (HP:0002850)	3.02482197
16	Cerebellar dysplasia (HP:0007033)	2.90671742
17	Renal cortical cysts (HP:0000803)	2.87896790
18	Pancreatic cysts (HP:0001737)	2.82913141
19	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.76821750
20	Abnormal protein N-linked glycosylation (HP:0012347)	2.76821750
21	Abnormal protein glycosylation (HP:0012346)	2.76821750
22	Abnormal glycosylation (HP:0012345)	2.76821750
23	Pancreatic fibrosis (HP:0100732)	2.73813653
24	Medial flaring of the eyebrow (HP:0010747)	2.70169717
25	Hyperglycinuria (HP:0003108)	2.68893016
26	Hyperglycinemia (HP:0002154)	2.66408843
27	Nephronophthisis (HP:0000090)	2.65576676
28	Acute necrotizing encephalopathy (HP:0006965)	2.64112125
29	Congenital stationary night blindness (HP:0007642)	2.62612213
30	IgG deficiency (HP:0004315)	2.61145018
31	Type I transferrin isoform profile (HP:0003642)	2.60509841
32	Increased muscle lipid content (HP:0009058)	2.55899876
33	Abnormality of glycine metabolism (HP:0010895)	2.51716977
34	Abnormality of serine family amino acid metabolism (HP:0010894)	2.51716977
35	Increased serum lactate (HP:0002151)	2.47871559
36	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.44157644
37	Severe combined immunodeficiency (HP:0004430)	2.42037269
38	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.39300219
39	Aplasia/hypoplasia of the uterus (HP:0008684)	2.39204801
40	Acute encephalopathy (HP:0006846)	2.39157569
41	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.38803161
42	Recurrent sinusitis (HP:0011108)	2.33714238
43	Meckel diverticulum (HP:0002245)	2.33420774
44	Congenital primary aphakia (HP:0007707)	2.29442513
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.29184887
46	Gait imbalance (HP:0002141)	2.26108424
47	Lissencephaly (HP:0001339)	2.25771819
48	Ragged-red muscle fibers (HP:0003200)	2.25636338
49	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.25529740
50	Abnormality of alanine metabolism (HP:0010916)	2.25529740
51	Hyperalaninemia (HP:0003348)	2.25529740
52	Tubulointerstitial nephritis (HP:0001970)	2.24357376
53	Abnormality of the ileum (HP:0001549)	2.24065975
54	Retinal dysplasia (HP:0007973)	2.24024753
55	Fibular aplasia (HP:0002990)	2.20971326
56	Lactic acidosis (HP:0003128)	2.19082139
57	Oligodactyly (hands) (HP:0001180)	2.16303617
58	Progressive microcephaly (HP:0000253)	2.15350485
59	Abnormality of the renal cortex (HP:0011035)	2.14825520
60	Short tibia (HP:0005736)	2.12529788
61	Progressive macrocephaly (HP:0004481)	2.12518965
62	Postaxial foot polydactyly (HP:0001830)	2.12331664
63	Nephrogenic diabetes insipidus (HP:0009806)	2.08647238
64	Abnormality of T cell physiology (HP:0011840)	2.07962682
65	Abnormality of DNA repair (HP:0003254)	2.07716086
66	Occipital encephalocele (HP:0002085)	2.07439894
67	Methylmalonic aciduria (HP:0012120)	2.05236928
68	Abnormality of the renal medulla (HP:0100957)	2.03161706
69	Abnormal rod and cone electroretinograms (HP:0008323)	2.01949413
70	Decreased central vision (HP:0007663)	2.00787543
71	Panhypogammaglobulinemia (HP:0003139)	1.98908092
72	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.98598211
73	Respiratory failure (HP:0002878)	1.98060574
74	Increased hepatocellular lipid droplets (HP:0006565)	1.96876399
75	Sloping forehead (HP:0000340)	1.95389176
76	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.95209845
77	Attenuation of retinal blood vessels (HP:0007843)	1.93891715
78	Dicarboxylic aciduria (HP:0003215)	1.93513085
79	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.93513085
80	Oligodactyly (HP:0012165)	1.92625653
81	Abolished electroretinogram (ERG) (HP:0000550)	1.92220590
82	Stomach cancer (HP:0012126)	1.91687983
83	CNS demyelination (HP:0007305)	1.91642417
84	Abnormality of chromosome stability (HP:0003220)	1.89832137
85	Abnormality of the preputium (HP:0100587)	1.87396064
86	Lipid accumulation in hepatocytes (HP:0006561)	1.87359183
87	Amyotrophic lateral sclerosis (HP:0007354)	1.87276769
88	Combined immunodeficiency (HP:0005387)	1.87061498
89	Abnormality of serum amino acid levels (HP:0003112)	1.84209024
90	Colon cancer (HP:0003003)	1.83459498
91	Focal motor seizures (HP:0011153)	1.83175508
92	3-Methylglutaconic aciduria (HP:0003535)	1.82828337
93	Albinism (HP:0001022)	1.82552503
94	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.82527846
95	Anencephaly (HP:0002323)	1.80823657
96	Hemiparesis (HP:0001269)	1.78085268
97	Cerebral edema (HP:0002181)	1.76439841
98	Postaxial hand polydactyly (HP:0001162)	1.76008900
99	Chromsome breakage (HP:0040012)	1.75352909
100	Methylmalonic acidemia (HP:0002912)	1.74639483

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.61371966
2	BCKDK	3.31779500
3	TESK2	2.96060360
4	MAP4K2	2.88533199
5	PNCK	2.51069917
6	VRK1	2.38925631
7	INSRR	2.34955787
8	KDR	2.12913896
9	WNK3	2.01281646
10	CSNK1G1	1.96744876
11	GRK1	1.96044645
12	CSNK1G3	1.90707849
13	MAP2K7	1.86496135
14	BMPR1B	1.84233891
15	VRK2	1.83521514
16	MAPK15	1.78803551
17	FRK	1.78689735
18	MAP3K4	1.76858120
19	WEE1	1.72519133
20	CSNK1A1L	1.70809720
21	PDK2	1.68743439
22	SRPK1	1.67972026
23	MAPK13	1.67822427
24	BRSK2	1.54718444
25	CSNK1G2	1.52675297
26	PLK4	1.51546678
27	BCR	1.50897941
28	CAMKK2	1.49822418
29	CCNB1	1.39700960
30	TAOK3	1.37909323
31	AKT3	1.37874181
32	PINK1	1.31762550
33	TSSK6	1.24675418
34	NLK	1.21286159
35	ATR	1.20641341
36	DYRK2	1.20257354
37	WNK4	1.20229684
38	PIM2	1.18500856
39	NUAK1	1.16332246
40	KIT	1.14363480
41	RPS6KA4	1.11362385
42	ADRBK2	1.07778500
43	FLT3	1.07333327
44	TXK	1.02065825
45	TTK	0.98521440
46	EPHA3	0.94126652
47	RPS6KA5	0.91408625
48	TEC	0.90707174
49	MAP4K1	0.87347452
50	CDC7	0.86273519
51	TNIK	0.84809766
52	IKBKB	0.84735218
53	CSF1R	0.84026444
54	ITK	0.83491976
55	CDK8	0.82204593
56	TRIM28	0.80453288
57	SYK	0.78985761
58	TBK1	0.78517853
59	TLK1	0.77657952
60	PBK	0.75942275
61	MARK1	0.71958964
62	PLK3	0.71179657
63	SCYL2	0.69789318
64	CLK1	0.66783839
65	IKBKE	0.65056641
66	PRKCI	0.65048068
67	ARAF	0.64838691
68	PLK1	0.64501425
69	PRKCE	0.62885079
70	GRK6	0.58972850
71	BRAF	0.55532820
72	PRKCQ	0.55292152
73	ATM	0.54979468
74	LYN	0.54396763
75	BUB1	0.54392203
76	CHEK2	0.51217696
77	FES	0.50679200
78	MAPK11	0.50383599
79	LCK	0.50354873
80	CDK3	0.48638446
81	MAPKAPK3	0.47883901
82	MAP3K13	0.47851964
83	PRKCG	0.42547351
84	PKN1	0.42427120
85	CDK4	0.39896544
86	PASK	0.39649902
87	EPHA4	0.39352883
88	CSNK1D	0.39158923
89	RAF1	0.38642508
90	PIM1	0.38276904
91	PLK2	0.37572246
92	CSNK2A1	0.36106680
93	MAP3K7	0.35777224
94	CSNK1A1	0.35282038
95	ADRBK1	0.33798770
96	NEK6	0.33743186
97	ERBB3	0.33176692
98	CDK9	0.32566751
99	EIF2AK3	0.32387536
100	NEK1	0.32180456

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	3.68865642
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.90932460
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.78119059
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.73490568
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.68079146
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.64973166
7	Base excision repair_Homo sapiens_hsa03410	2.55667938
8	Proteasome_Homo sapiens_hsa03050	2.50603825
9	RNA polymerase_Homo sapiens_hsa03020	2.40471173
10	Homologous recombination_Homo sapiens_hsa03440	2.39349575
11	DNA replication_Homo sapiens_hsa03030	2.05996235
12	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.04380130
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.04216743
14	One carbon pool by folate_Homo sapiens_hsa00670	2.03727641
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.03476748
16	Butanoate metabolism_Homo sapiens_hsa00650	2.01745857
17	Mismatch repair_Homo sapiens_hsa03430	1.91325742
18	Parkinsons disease_Homo sapiens_hsa05012	1.89487520
19	Propanoate metabolism_Homo sapiens_hsa00640	1.78571772
20	Spliceosome_Homo sapiens_hsa03040	1.74301153
21	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.73272710
22	RNA degradation_Homo sapiens_hsa03018	1.73123616
23	Phototransduction_Homo sapiens_hsa04744	1.65078846
24	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.57396023
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.52870329
26	Peroxisome_Homo sapiens_hsa04146	1.52516605
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.51809537
28	Fatty acid elongation_Homo sapiens_hsa00062	1.48036520
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.45991393
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.43946882
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.40791301
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.40234457
33	Regulation of autophagy_Homo sapiens_hsa04140	1.36595564
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.33293328
35	Protein export_Homo sapiens_hsa03060	1.31102004
36	Steroid biosynthesis_Homo sapiens_hsa00100	1.24718747
37	Purine metabolism_Homo sapiens_hsa00230	1.20562683
38	Sulfur relay system_Homo sapiens_hsa04122	1.19125138
39	Huntingtons disease_Homo sapiens_hsa05016	1.18162019
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17809141
41	RNA transport_Homo sapiens_hsa03013	1.15209312
42	Antigen processing and presentation_Homo sapiens_hsa04612	1.10388679
43	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.09217892
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.05100736
45	Allograft rejection_Homo sapiens_hsa05330	1.04596428
46	Graft-versus-host disease_Homo sapiens_hsa05332	1.00829282
47	Basal transcription factors_Homo sapiens_hsa03022	0.94109493
48	Type I diabetes mellitus_Homo sapiens_hsa04940	0.93042829
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.90933853
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87903178
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.87057160
52	Asthma_Homo sapiens_hsa05310	0.84347524
53	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.83134446
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80871880
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.80458646
56	Alzheimers disease_Homo sapiens_hsa05010	0.79882389
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79182247
58	ABC transporters_Homo sapiens_hsa02010	0.77217137
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76361374
60	Metabolic pathways_Homo sapiens_hsa01100	0.76069201
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.73644383
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.72163301
63	Carbon metabolism_Homo sapiens_hsa01200	0.65865610
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65669233
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61270845
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.60026633
67	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.58923470
68	Olfactory transduction_Homo sapiens_hsa04740	0.55696811
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.54883186
70	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.54656902
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52938293
72	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.52232456
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.51060055
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.49449845
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48150310
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47390471
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47359924
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46991004
79	Taste transduction_Homo sapiens_hsa04742	0.46641542
80	Caffeine metabolism_Homo sapiens_hsa00232	0.45673152
81	p53 signaling pathway_Homo sapiens_hsa04115	0.45475621
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42775973
83	Glutathione metabolism_Homo sapiens_hsa00480	0.42727599
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42465419
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42377812
86	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.42005914
87	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.41338768
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.41145156
89	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.39533291
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.39468310
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37971008
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.36996005
93	Folate biosynthesis_Homo sapiens_hsa00790	0.36063020
94	Nicotine addiction_Homo sapiens_hsa05033	0.35947777
95	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.34913913
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33408136
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32141487
98	Cardiac muscle contraction_Homo sapiens_hsa04260	0.30569493
99	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.30179441
100	Cell cycle_Homo sapiens_hsa04110	0.28765302

SDHAP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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