SDHB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.25025191
2ATP synthesis coupled proton transport (GO:0015986)7.67461301
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.67461301
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.28187729
5* respiratory electron transport chain (GO:0022904)6.88123215
6* electron transport chain (GO:0022900)6.71587311
7* tricarboxylic acid cycle (GO:0006099)6.62649056
8proteasome assembly (GO:0043248)5.69198358
9oxidative phosphorylation (GO:0006119)5.64861062
10NADH metabolic process (GO:0006734)5.52551216
11regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.80664432
12ATP biosynthetic process (GO:0006754)4.71336373
13sarcomere organization (GO:0045214)4.70457434
14regulation of acyl-CoA biosynthetic process (GO:0050812)4.66915834
15lysine catabolic process (GO:0006554)4.49124667
16lysine metabolic process (GO:0006553)4.49124667
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.46052260
18cellular ketone body metabolic process (GO:0046950)4.33671211
19oxaloacetate metabolic process (GO:0006107)4.32062973
20regulation of coenzyme metabolic process (GO:0051196)4.30661419
21regulation of cofactor metabolic process (GO:0051193)4.30661419
22aspartate family amino acid catabolic process (GO:0009068)4.29333795
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.25256484
24regulation of cellular amino acid metabolic process (GO:0006521)4.20350662
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.16587831
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.16587831
27NADH dehydrogenase complex assembly (GO:0010257)4.16587831
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.16178608
292-oxoglutarate metabolic process (GO:0006103)4.15895148
30branched-chain amino acid catabolic process (GO:0009083)4.13451940
31muscle filament sliding (GO:0030049)4.13236333
32actin-myosin filament sliding (GO:0033275)4.13236333
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.09752623
34negative regulation of ligase activity (GO:0051352)4.09752623
35protein complex biogenesis (GO:0070271)4.05391159
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.03207609
37fatty acid beta-oxidation (GO:0006635)4.02835019
38* succinate metabolic process (GO:0006105)4.01338939
39purine nucleoside triphosphate biosynthetic process (GO:0009145)4.01101737
40cardiac myofibril assembly (GO:0055003)4.00590227
41purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.99753727
42regulation of mitochondrial translation (GO:0070129)3.98686015
43inner mitochondrial membrane organization (GO:0007007)3.98521669
44hydrogen ion transmembrane transport (GO:1902600)3.92281700
45heart process (GO:0003015)3.91580351
46heart contraction (GO:0060047)3.91580351
47ketone body metabolic process (GO:1902224)3.91329638
48acetyl-CoA metabolic process (GO:0006084)3.90904057
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.86628858
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.84548930
51carnitine shuttle (GO:0006853)3.83730583
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.80664026
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.80664026
54protein targeting to mitochondrion (GO:0006626)3.79845301
55mitochondrial respiratory chain complex assembly (GO:0033108)3.77508550
56ribosome assembly (GO:0042255)3.76355240
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.76351337
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.76351337
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.76351337
60short-chain fatty acid metabolic process (GO:0046459)3.75816850
61myofibril assembly (GO:0030239)3.73037742
62positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.72829863
63fatty acid catabolic process (GO:0009062)3.70133826
64signal transduction involved in DNA integrity checkpoint (GO:0072401)3.69214668
65signal transduction involved in DNA damage checkpoint (GO:0072422)3.69214668
66cullin deneddylation (GO:0010388)3.68028842
67protein maturation by protein folding (GO:0022417)3.66177704
68glyoxylate metabolic process (GO:0046487)3.66029662
69positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.64903583
70positive regulation of ligase activity (GO:0051351)3.63886725
71fatty acid transmembrane transport (GO:1902001)3.61068969
72branched-chain amino acid metabolic process (GO:0009081)3.60758689
73negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.60372745
74signal transduction involved in cell cycle checkpoint (GO:0072395)3.59865104
75ubiquinone biosynthetic process (GO:0006744)3.57849497
76quinone biosynthetic process (GO:1901663)3.57849497
77cardiac muscle contraction (GO:0060048)3.57579046
78nucleobase-containing small molecule interconversion (GO:0015949)3.54756732
79fatty acid oxidation (GO:0019395)3.51867904
80ribonucleoside triphosphate biosynthetic process (GO:0009201)3.51172152
81proton transport (GO:0015992)3.47417738
82lipid oxidation (GO:0034440)3.45727536
83protein deneddylation (GO:0000338)3.45238850
84hydrogen transport (GO:0006818)3.44733562
85* aerobic respiration (GO:0009060)3.44670521
86regulation of relaxation of muscle (GO:1901077)3.42777515
87regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.42028272
88protein localization to mitochondrion (GO:0070585)3.41722883
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.41008333
90establishment of protein localization to mitochondrion (GO:0072655)3.40937976
91tricarboxylic acid metabolic process (GO:0072350)3.38175281
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.38129277
93L-phenylalanine metabolic process (GO:0006558)3.38129277
94chaperone-mediated protein transport (GO:0072321)3.37857129
95L-phenylalanine catabolic process (GO:0006559)3.37498214
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.37498214
97regulation of sulfur metabolic process (GO:0042762)3.35208428
98regulation of ubiquitin-protein transferase activity (GO:0051438)3.34280764
99ubiquinone metabolic process (GO:0006743)3.31324733
100actin-mediated cell contraction (GO:0070252)3.30994521
101monocarboxylic acid catabolic process (GO:0072329)3.30836840
102regulation of ligase activity (GO:0051340)3.28476277
103regulation of sequestering of triglyceride (GO:0010889)3.28035122
104formation of translation preinitiation complex (GO:0001731)3.27182531
105deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25980129
106antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.23738756
107regulation of actin filament-based movement (GO:1903115)3.23495956
108regulation of oxidative phosphorylation (GO:0002082)3.22613425
109regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.19477975
110aldehyde catabolic process (GO:0046185)3.19045439
111respiratory chain complex IV assembly (GO:0008535)3.18247927
112cardiac muscle tissue morphogenesis (GO:0055008)3.16371779
113AMP metabolic process (GO:0046033)3.13430790
114regulation of cellular amine metabolic process (GO:0033238)3.13097310
115purine nucleoside monophosphate biosynthetic process (GO:0009127)3.12086810
116purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.12086810
117ribosomal large subunit biogenesis (GO:0042273)3.11420597
118nucleoside triphosphate biosynthetic process (GO:0009142)3.10651491
119regulation of skeletal muscle contraction (GO:0014819)3.10073488
120regulation of cell communication by electrical coupling (GO:0010649)3.09457561
121negative regulation of potassium ion transmembrane transport (GO:1901380)3.08394547
122mitochondrial transport (GO:0006839)3.06295021
123acyl-CoA metabolic process (GO:0006637)3.05876138
124thioester metabolic process (GO:0035383)3.05876138
125rRNA modification (GO:0000154)3.04145093
126* generation of precursor metabolites and energy (GO:0006091)3.03225281
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01298748
128positive regulation of cell cycle arrest (GO:0071158)3.00388029
129NAD metabolic process (GO:0019674)2.99222725
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.98763691
131termination of RNA polymerase III transcription (GO:0006386)2.98763691
132amino-acid betaine transport (GO:0015838)2.98321012
133carnitine transport (GO:0015879)2.98321012
134cardiac muscle cell development (GO:0055013)2.98243131
135ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.97073996
136carnitine transmembrane transport (GO:1902603)2.97027345
137deoxyribonucleotide biosynthetic process (GO:0009263)2.97016351
1382-deoxyribonucleotide biosynthetic process (GO:0009265)2.95616008
139deoxyribose phosphate biosynthetic process (GO:0046385)2.95616008
140pteridine-containing compound biosynthetic process (GO:0042559)2.93397724
141* cellular respiration (GO:0045333)2.92569249
142pseudouridine synthesis (GO:0001522)2.91789571
143thioester biosynthetic process (GO:0035384)2.91574014
144acyl-CoA biosynthetic process (GO:0071616)2.91574014
145maturation of SSU-rRNA (GO:0030490)2.91402249
146telomere maintenance via semi-conservative replication (GO:0032201)2.90469429
147purine nucleotide salvage (GO:0032261)2.89072074
148IMP biosynthetic process (GO:0006188)2.88618032
149striated muscle contraction (GO:0006941)2.88567435
150creatine metabolic process (GO:0006600)2.88312235
151adult heart development (GO:0007512)2.88029292
152tRNA aminoacylation for protein translation (GO:0006418)2.87823212
153regulation of cellular respiration (GO:0043457)2.87288849
154cardiac muscle hypertrophy (GO:0003300)2.86932749
155DNA strand elongation involved in DNA replication (GO:0006271)2.86740635
156maturation of 5.8S rRNA (GO:0000460)2.85452286
157cytochrome complex assembly (GO:0017004)2.82142384
158nucleoside monophosphate biosynthetic process (GO:0009124)2.81671827
159gluconeogenesis (GO:0006094)2.80983501
160amino acid activation (GO:0043038)2.80608790
161tRNA aminoacylation (GO:0043039)2.80608790
162negative regulation of protein ubiquitination (GO:0031397)2.79784238
163IMP metabolic process (GO:0046040)2.79098825
164transcription from mitochondrial promoter (GO:0006390)2.78530953
165deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.78525424
166ribonucleoside monophosphate biosynthetic process (GO:0009156)2.78356798
167guanosine-containing compound biosynthetic process (GO:1901070)2.77822183
168translation (GO:0006412)2.77477495
169DNA strand elongation (GO:0022616)2.76378428
170ribosomal small subunit biogenesis (GO:0042274)2.75115474
171DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.73421261
172negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72520794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.95904337
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.63235716
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.61580688
4E2F7_22180533_ChIP-Seq_HELA_Human3.98008649
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.60166569
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43465318
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.31515944
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.30308286
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15291454
10PPARA_22158963_ChIP-Seq_LIVER_Mouse3.00617849
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.82851946
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.64944259
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57145968
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.54895172
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52218930
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.48619662
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46783534
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.43368444
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34301851
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.27083774
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23504832
22VDR_23849224_ChIP-Seq_CD4+_Human2.22859418
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20663770
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19505124
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.17096660
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12706310
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09808528
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08952063
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05017132
30FOXP3_21729870_ChIP-Seq_TREG_Human2.04167210
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.03515686
32XRN2_22483619_ChIP-Seq_HELA_Human2.00447941
33* GABP_19822575_ChIP-Seq_HepG2_Human1.99555772
34* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95156746
35ELK1_19687146_ChIP-ChIP_HELA_Human1.93415544
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87899106
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84167032
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83809987
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83000803
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.75306656
41TTF2_22483619_ChIP-Seq_HELA_Human1.72552023
42* ETS1_20019798_ChIP-Seq_JURKAT_Human1.72067435
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68057765
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67082999
45VDR_22108803_ChIP-Seq_LS180_Human1.64990278
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62243005
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61181667
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59072225
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57867828
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55046653
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54917583
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52896913
53AR_21909140_ChIP-Seq_LNCAP_Human1.52644236
54TFEB_21752829_ChIP-Seq_HELA_Human1.52204188
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52071731
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.51952922
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49492447
58HTT_18923047_ChIP-ChIP_STHdh_Human1.46800020
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45406064
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43847929
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43499380
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.40138290
63* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38949225
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.37465841
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37360825
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36209686
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35400922
68* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35120148
69TAF15_26573619_Chip-Seq_HEK293_Human1.32567675
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30488274
71* KDM5A_27292631_Chip-Seq_BREAST_Human1.30448799
72* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25585692
73GATA4_21415370_ChIP-Seq_HL-1_Mouse1.24933248
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23779259
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23676596
76MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22729785
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21858320
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20980720
79* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19706868
80* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18618142
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17983133
82* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15809487
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.14622672
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.14622672
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.14562037
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14374000
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13515808
88* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12519086
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12182928
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11826586
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10773785
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08660097
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07872942
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07100055
95* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05802459
96MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05147312
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04998938
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04888725
99ZNF263_19887448_ChIP-Seq_K562_Human1.03183085
100DCP1A_22483619_ChIP-Seq_HELA_Human1.00606366
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00286685
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.99404405
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97786626
104PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97381142
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97292231
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94126898
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.93728350
108EZH2_22144423_ChIP-Seq_EOC_Human0.93590294
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93282517
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92894809
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90666413
112OCT4_20526341_ChIP-Seq_ESCs_Human0.90400080
113AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90161552
114CIITA_25753668_ChIP-Seq_RAJI_Human0.87089470
115TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86079615
116* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85631210
117* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85274680
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84929300
119CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84657797
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.84614246
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83311473
122GBX2_23144817_ChIP-Seq_PC3_Human0.82022877
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81997181
124* TAF2_19829295_ChIP-Seq_ESCs_Human0.80903644
125MYC_18940864_ChIP-ChIP_HL60_Human0.79877111
126NANOG_20526341_ChIP-Seq_ESCs_Human0.78451563
127EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78444577
128* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78056313
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75666288
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75119404
131ERG_20517297_ChIP-Seq_VCAP_Human0.75065483
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74379223
133SPI1_23547873_ChIP-Seq_NB4_Human0.74156771
134CLOCK_20551151_ChIP-Seq_293T_Human0.74100960
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73941641
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73941075
137NCOR_22424771_ChIP-Seq_293T_Human0.73089852
138YY1_22570637_ChIP-Seq_MALME-3M_Human0.72634535
139EGR1_19032775_ChIP-ChIP_M12_Human0.72546031
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.67430570
141BCL6_27268052_Chip-Seq_Bcells_Human0.67359446
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66988553
143* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66563579
144AR_20517297_ChIP-Seq_VCAP_Human0.65747930
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.65288647
146MYC_19829295_ChIP-Seq_ESCs_Human0.64289994
147REST_18959480_ChIP-ChIP_MESCs_Mouse0.64135683
148TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.63996983
149ELF1_17652178_ChIP-ChIP_JURKAT_Human0.63839393
150BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63709260
151CTBP1_25329375_ChIP-Seq_LNCAP_Human0.63655850
152NANOG_19829295_ChIP-Seq_ESCs_Human0.63431170
153SOX2_19829295_ChIP-Seq_ESCs_Human0.63431170
154SOX2_22085726_ChIP-Seq_NPCs_Mouse0.62791835
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.62176704
156RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.62109171
157NR3C1_23031785_ChIP-Seq_PC12_Mouse0.61407575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.90658444
2MP0003646_muscle_fatigue4.73893392
3MP0004084_abnormal_cardiac_muscle3.82648584
4MP0000751_myopathy3.76527562
5MP0004215_abnormal_myocardial_fiber3.45156033
6MP0004036_abnormal_muscle_relaxation3.38142641
7MP0003806_abnormal_nucleotide_metabolis3.37766983
8MP0000749_muscle_degeneration3.31036873
9MP0005360_urolithiasis3.22850722
10MP0006036_abnormal_mitochondrial_physio3.17956357
11MP0005330_cardiomyopathy3.03373042
12MP0002139_abnormal_hepatobiliary_system2.96733654
13MP0003693_abnormal_embryo_hatching2.80764464
14MP0004957_abnormal_blastocyst_morpholog2.68406670
15MP0008058_abnormal_DNA_repair2.55244433
16MP0005085_abnormal_gallbladder_physiolo2.54362085
17MP0010094_abnormal_chromosome_stability2.45360267
18MP0002972_abnormal_cardiac_muscle2.32584443
19MP0006035_abnormal_mitochondrial_morpho2.21729881
20MP0003111_abnormal_nucleus_morphology2.21344445
21MP0008875_abnormal_xenobiotic_pharmacok2.18820936
22MP0003195_calcinosis2.18123401
23MP0004130_abnormal_muscle_cell2.17286919
24MP0008775_abnormal_heart_ventricle2.08898596
25MP0003137_abnormal_impulse_conducting2.05699436
26MP0005620_abnormal_muscle_contractility2.05360352
27MP0005332_abnormal_amino_acid2.02689768
28MP0005365_abnormal_bile_salt2.02578762
29MP0004087_abnormal_muscle_fiber1.98973596
30MP0005408_hypopigmentation1.97740351
31MP0003786_premature_aging1.95377954
32MP0003077_abnormal_cell_cycle1.88384707
33MP0008007_abnormal_cellular_replicative1.86841334
34MP0001661_extended_life_span1.86735935
35MP0003718_maternal_effect1.85522987
36MP0001544_abnormal_cardiovascular_syste1.84784687
37MP0005385_cardiovascular_system_phenoty1.84784687
38MP0002163_abnormal_gland_morphology1.79826619
39MP0002106_abnormal_muscle_physiology1.76587850
40MP0002877_abnormal_melanocyte_morpholog1.74345036
41MP0002269_muscular_atrophy1.73804748
42MP0006138_congestive_heart_failure1.72820799
43MP0004484_altered_response_of1.68942293
44MP0005058_abnormal_lysosome_morphology1.67894609
45MP0000750_abnormal_muscle_regeneration1.67278476
46MP0003221_abnormal_cardiomyocyte_apopto1.66585883
47MP0001529_abnormal_vocalization1.66133231
48MP0004043_abnormal_pH_regulation1.65056076
49MP0004145_abnormal_muscle_electrophysio1.61608466
50MP0000747_muscle_weakness1.61579448
51MP0008932_abnormal_embryonic_tissue1.59821851
52MP0002332_abnormal_exercise_endurance1.55617953
53MP0004085_abnormal_heartbeat1.51290745
54MP0005083_abnormal_biliary_tract1.47320589
55MP0003186_abnormal_redox_activity1.43923327
56MP0002822_catalepsy1.43214094
57MP0005451_abnormal_body_composition1.43198057
58MP0005369_muscle_phenotype1.41085542
59MP0005584_abnormal_enzyme/coenzyme_acti1.36721936
60MP0000759_abnormal_skeletal_muscle1.35029058
61MP0005379_endocrine/exocrine_gland_phen1.34479871
62MP0010630_abnormal_cardiac_muscle1.34048404
63MP0000358_abnormal_cell_content/1.33766749
64MP0005670_abnormal_white_adipose1.32578516
65MP0004147_increased_porphyrin_level1.30821534
66MP0005266_abnormal_metabolism1.28831131
67MP0010329_abnormal_lipoprotein_level1.27747763
68MP0001853_heart_inflammation1.24458894
69MP0009333_abnormal_splenocyte_physiolog1.21251771
70MP0005535_abnormal_body_temperature1.20450455
71MP0005319_abnormal_enzyme/_coenzyme1.19352064
72MP0000230_abnormal_systemic_arterial1.18677434
73MP0004233_abnormal_muscle_weight1.14015261
74MP0002118_abnormal_lipid_homeostasis1.13523782
75MP0009840_abnormal_foam_cell1.12506209
76MP0001764_abnormal_homeostasis1.10677230
77MP0001730_embryonic_growth_arrest1.09612082
78MP0005666_abnormal_adipose_tissue1.09416720
79MP0001666_abnormal_nutrient_absorption1.07884327
80MP0003880_abnormal_central_pattern1.06901925
81MP0001905_abnormal_dopamine_level1.05940116
82MP0002132_abnormal_respiratory_system1.04801088
83MP0010234_abnormal_vibrissa_follicle1.03960887
84MP0008260_abnormal_autophagy1.03815027
85MP0002127_abnormal_cardiovascular_syste1.02479573
86MP0006276_abnormal_autonomic_nervous1.00668773
87MP0009643_abnormal_urine_homeostasis0.98854982
88MP0005636_abnormal_mineral_homeostasis0.98378073
89MP0002090_abnormal_vision0.94670424
90MP0002876_abnormal_thyroid_physiology0.90346454
91MP0004142_abnormal_muscle_tone0.90223773
92MP0009697_abnormal_copulation0.90112855
93MP0005165_increased_susceptibility_to0.90034986
94MP0000343_altered_response_to0.89704566
95MP0005075_abnormal_melanosome_morpholog0.89648134
96MP0003329_amyloid_beta_deposits0.88860769
97MP0000313_abnormal_cell_death0.85453495
98MP0002736_abnormal_nociception_after0.84639422
99MP0005376_homeostasis/metabolism_phenot0.84277248
100MP0003191_abnormal_cellular_cholesterol0.84271539
101MP0003950_abnormal_plasma_membrane0.83063620
102MP0003252_abnormal_bile_duct0.82229643
103MP0002078_abnormal_glucose_homeostasis0.80665752
104MP0004924_abnormal_behavior0.80267459
105MP0005386_behavior/neurological_phenoty0.80267459
106MP0003828_pulmonary_edema0.79473273
107MP0003656_abnormal_erythrocyte_physiolo0.78363238
108MP0002971_abnormal_brown_adipose0.77136604
109MP0000013_abnormal_adipose_tissue0.76683920
110MP0000350_abnormal_cell_proliferation0.74882596
111MP0004019_abnormal_vitamin_homeostasis0.71518476
112MP0000015_abnormal_ear_pigmentation0.70313059
113MP0003941_abnormal_skin_development0.69874351
114MP0001881_abnormal_mammary_gland0.69793391
115MP0002272_abnormal_nervous_system0.68560991
116MP0001727_abnormal_embryo_implantation0.67170377
117MP0000609_abnormal_liver_physiology0.66932640
118MP0008469_abnormal_protein_level0.66694057
119MP0001756_abnormal_urination0.64815123
120MP0009785_altered_susceptibility_to0.64666381
121MP0002019_abnormal_tumor_incidence0.64191691
122MP0004510_myositis0.63432877
123MP0005166_decreased_susceptibility_to0.63198772
124MP0005084_abnormal_gallbladder_morpholo0.63016602
125MP0001697_abnormal_embryo_size0.62453450
126MP0002138_abnormal_hepatobiliary_system0.61843216
127MP0001440_abnormal_grooming_behavior0.61741428
128MP0005395_other_phenotype0.61309000
129MP0010352_gastrointestinal_tract_polyps0.60819232
130MP0002064_seizures0.58404596
131MP0009046_muscle_twitch0.57075983
132MP0009745_abnormal_behavioral_response0.55859583
133MP0000372_irregular_coat_pigmentation0.54474721
134MP0005375_adipose_tissue_phenotype0.54188755
135MP0001765_abnormal_ion_homeostasis0.54166603
136MP0002638_abnormal_pupillary_reflex0.53557464
137MP0005448_abnormal_energy_balance0.53408862
138MP0000604_amyloidosis0.52768924

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.18402344
2Abnormal mitochondria in muscle tissue (HP:0008316)6.00671385
3Acute encephalopathy (HP:0006846)5.65955125
4Hepatic necrosis (HP:0002605)5.28276670
5Mitochondrial inheritance (HP:0001427)5.27340113
6Progressive macrocephaly (HP:0004481)5.15409674
7Hepatocellular necrosis (HP:0001404)5.09337410
8Increased CSF lactate (HP:0002490)4.83661776
9Cerebral edema (HP:0002181)4.80589544
10Abnormality of glycolysis (HP:0004366)4.54431975
11Increased serum pyruvate (HP:0003542)4.54431975
12Sudden death (HP:0001699)4.46158724
13Nemaline bodies (HP:0003798)4.22032389
14Exercise-induced myalgia (HP:0003738)4.12806871
15Muscle fiber inclusion bodies (HP:0100299)4.12315480
16Myoglobinuria (HP:0002913)4.05536848
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.04237358
18Calf muscle hypertrophy (HP:0008981)3.97855160
19Lactic acidosis (HP:0003128)3.97180706
20Increased muscle lipid content (HP:0009058)3.89843150
21Exercise-induced muscle cramps (HP:0003710)3.85590913
22Muscle hypertrophy of the lower extremities (HP:0008968)3.85226900
23Increased intramyocellular lipid droplets (HP:0012240)3.78842074
24Abnormality of fatty-acid metabolism (HP:0004359)3.68376115
25Respiratory failure (HP:0002878)3.63901021
26Dicarboxylic aciduria (HP:0003215)3.61161272
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.61161272
28Exercise intolerance (HP:0003546)3.60606918
29Ventricular tachycardia (HP:0004756)3.60073362
30Lipid accumulation in hepatocytes (HP:0006561)3.52594161
31Rhabdomyolysis (HP:0003201)3.44487621
32Ketoacidosis (HP:0001993)3.35119363
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.35003316
34Decreased activity of mitochondrial respiratory chain (HP:0008972)3.35003316
35Increased hepatocellular lipid droplets (HP:0006565)3.27547559
36* Palpitations (HP:0001962)3.23124873
37Increased serum lactate (HP:0002151)3.20391802
38Lethargy (HP:0001254)3.15688156
39Hypoglycemic coma (HP:0001325)3.09388248
40Generalized aminoaciduria (HP:0002909)3.09031387
41Ketosis (HP:0001946)3.08744848
42Leukodystrophy (HP:0002415)3.05451125
43Lipoatrophy (HP:0100578)3.04470062
44Muscle fiber splitting (HP:0003555)3.02375848
45Abnormality of the calf musculature (HP:0001430)3.00623215
46Optic disc pallor (HP:0000543)2.96906996
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96089172
48Atrial fibrillation (HP:0005110)2.95728105
49Hyperammonemia (HP:0001987)2.95237040
50Type I transferrin isoform profile (HP:0003642)2.91945231
51Hyperglycinuria (HP:0003108)2.89647493
52Microvesicular hepatic steatosis (HP:0001414)2.78187198
53Renal Fanconi syndrome (HP:0001994)2.77107047
54Dilated cardiomyopathy (HP:0001644)2.76173086
55Glycosuria (HP:0003076)2.75556256
56Abnormality of urine glucose concentration (HP:0011016)2.75556256
57Ragged-red muscle fibers (HP:0003200)2.74358058
58Primary atrial arrhythmia (HP:0001692)2.73796444
59Supraventricular tachycardia (HP:0004755)2.72504397
60Abnormality of glycine metabolism (HP:0010895)2.68705082
61Abnormality of serine family amino acid metabolism (HP:0010894)2.68705082
62Vomiting (HP:0002013)2.65780778
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.65384766
64CNS demyelination (HP:0007305)2.65060897
65Supraventricular arrhythmia (HP:0005115)2.63405908
66Metabolic acidosis (HP:0001942)2.61712935
67Reduced antithrombin III activity (HP:0001976)2.59942967
68Syncope (HP:0001279)2.58564192
69Degeneration of anterior horn cells (HP:0002398)2.55288807
70Abnormality of the anterior horn cell (HP:0006802)2.55288807
71Methylmalonic aciduria (HP:0012120)2.53650069
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53276787
73Abnormality of alanine metabolism (HP:0010916)2.53276787
74Hyperalaninemia (HP:0003348)2.53276787
75Abnormality of methionine metabolism (HP:0010901)2.53128450
76Progressive muscle weakness (HP:0003323)2.53090543
77Myotonia (HP:0002486)2.47668329
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45877173
79EMG: myopathic abnormalities (HP:0003458)2.45009259
80Proximal tubulopathy (HP:0000114)2.44915314
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.42743721
82Muscle stiffness (HP:0003552)2.38458200
83Hyporeflexia of lower limbs (HP:0002600)2.36890167
84Hypokinesia (HP:0002375)2.36461764
853-Methylglutaconic aciduria (HP:0003535)2.34331371
86Asymmetric septal hypertrophy (HP:0001670)2.32047207
87* Neuroendocrine neoplasm (HP:0100634)2.30471813
88Abnormal protein glycosylation (HP:0012346)2.29114185
89Abnormal glycosylation (HP:0012345)2.29114185
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29114185
91Abnormal protein N-linked glycosylation (HP:0012347)2.29114185
92Right ventricular cardiomyopathy (HP:0011663)2.28585955
93Subaortic stenosis (HP:0001682)2.28359791
94Abnormality of the left ventricular outflow tract (HP:0011103)2.28359791
95Hyperglycinemia (HP:0002154)2.26935227
96Nausea (HP:0002018)2.25130042
97Prolonged QT interval (HP:0001657)2.23040230
98* Pheochromocytoma (HP:0002666)2.22833883
99Respiratory difficulties (HP:0002880)2.19839122
100Centrally nucleated skeletal muscle fibers (HP:0003687)2.18099812
101Cerebral hypomyelination (HP:0006808)2.13307298
102Testicular atrophy (HP:0000029)2.10755716
103Myopathic facies (HP:0002058)2.10317150
104Neck muscle weakness (HP:0000467)2.09536427
105Cholelithiasis (HP:0001081)2.08504432
106Ventricular arrhythmia (HP:0004308)2.07623898
107Multiple enchondromatosis (HP:0005701)2.05966542
108X-linked dominant inheritance (HP:0001423)2.05438614
109Gout (HP:0001997)2.02894419
110Methylmalonic acidemia (HP:0002912)2.02281245
111Abnormal gallbladder morphology (HP:0012437)2.00648263
112Emotional lability (HP:0000712)1.99965653
113Distal lower limb muscle weakness (HP:0009053)1.99467288
114Bundle branch block (HP:0011710)1.99278066
115Type 1 muscle fiber predominance (HP:0003803)1.98103470
116Increased connective tissue (HP:0009025)1.98023370
117Rimmed vacuoles (HP:0003805)1.97310306
118Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96253228
119Left ventricular hypertrophy (HP:0001712)1.93425841
120Gliosis (HP:0002171)1.92701238
121Abnormality of serum amino acid levels (HP:0003112)1.92481571
122Cholecystitis (HP:0001082)1.91500398
123Abnormal gallbladder physiology (HP:0012438)1.91500398
124Heart block (HP:0012722)1.88417954
125Hypobetalipoproteinemia (HP:0003563)1.87901292
126Exertional dyspnea (HP:0002875)1.87309972
127Paralysis (HP:0003470)1.86828277
128Macrocytic anemia (HP:0001972)1.78266557
129Pancytopenia (HP:0001876)1.76814290
130Reduced subcutaneous adipose tissue (HP:0003758)1.74148177
131Aplastic anemia (HP:0001915)1.73822517
132Abnormality of sulfur amino acid metabolism (HP:0004339)1.70265762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.83637094
2OBSCN4.37881667
3MYLK4.24115623
4PDK43.72601699
5PDK33.72601699
6TTN3.08696736
7PHKG22.98868616
8PHKG12.98868616
9NME12.79426274
10LMTK22.43488970
11WNK42.37134688
12PDK22.33457985
13SCYL22.27958016
14MUSK2.22544549
15VRK22.18395686
16PINK12.03507256
17NEK11.99620962
18OXSR11.95454981
19STK391.95431831
20TSSK61.91281048
21GRK71.85066936
22MAP3K121.84965826
23PIK3CA1.77983520
24NME21.75936524
25IRAK31.67389725
26PIM21.64121190
27TTK1.55400776
28SRPK11.54056908
29ARAF1.46099288
30STK161.44201035
31TESK21.42230196
32TRIM281.38862521
33CDC71.36863382
34TESK11.34840702
35CASK1.25379108
36PAK41.22719563
37CAMK2D1.20721418
38LIMK11.16658359
39STK241.16400335
40VRK11.14656335
41TIE11.12299969
42ILK1.04579911
43PLK31.02582558
44MAP2K41.00970151
45STK41.00268883
46WEE11.00239092
47DAPK30.98024381
48WNK30.97807793
49PLK10.97232550
50MAPK120.97142765
51PKN10.97024976
52STK38L0.94583470
53CAMK2G0.93195604
54MST40.93063235
55MAP2K70.91063573
56BCR0.90236792
57CAMK2A0.88763170
58PAK30.85145700
59KDR0.84876102
60RAF10.84573939
61AURKB0.84035204
62BRSK10.84004086
63CDK190.82330703
64GRK50.81263426
65MAP3K80.80735748
66PKN20.79350243
67AURKA0.76466649
68AKT20.75240147
69PLK40.74616333
70PBK0.73229858
71MAP3K40.73178929
72PAK10.71511837
73ABL20.70899650
74BMPR20.70708442
75EIF2AK10.69740228
76CSNK1G30.69544604
77LRRK20.68701364
78PIK3CG0.67726172
79ADRBK20.67285831
80ERBB30.66595262
81PRKACA0.65322828
82MST1R0.64817820
83PRKCI0.64746047
84BUB10.63789992
85CAMK2B0.63714439
86MAPKAPK30.61645403
87ROCK20.60289000
88TLK10.60017830
89BRAF0.59486480
90ROCK10.59470059
91STK100.59042497
92CSNK2A20.58695831
93PRKCE0.58267830
94MAP3K110.57539001
95EIF2AK20.56821169
96PTK2B0.56557127
97RPS6KA50.54917727
98CSNK2A10.54797807
99PRKD10.54735851
100CLK10.54399458
101CSNK1G10.53053329
102MAP3K30.52127598
103EPHA20.52066468
104TAOK20.50370193
105ADRBK10.49712761
106RPS6KB20.48457054
107PRKACB0.48022724
108PRKACG0.47656425
109PLK20.47064056
110SIK30.46259884
111ERBB40.46096981
112DMPK0.45877919
113CDK80.43103605
114MAP2K60.42289385
115CCNB10.41654719
116PRKAA10.40205440
117INSRR0.39738215
118EIF2AK30.39371568
119SGK2230.38923527
120SGK4940.38923527
121CHEK10.37304174
122PRKCG0.37095743
123CSNK1A1L0.37051922
124ZAK0.37029898
125NEK90.36982614
126CHEK20.36972750
127MAP3K50.35027669
128BRSK20.34663346
129ATR0.34447389
130UHMK10.34104237
131PRKAA20.34074513
132TBK10.33755605
133MAPK40.33720161
134DAPK10.32650815
135MINK10.32645775
136PRKCQ0.31907591
137MAP2K30.31898536
138EPHA40.31847346
139PDPK10.31639698
140CSNK1G20.31612223
141MAP2K10.31217969
142DYRK20.30859610
143FLT30.30140388
144KSR20.29305218
145ALK0.28788115
146BMPR1B0.28541704
147CAMK40.28118717
148MAP3K20.27800124
149PRKG20.27485711
150MAP3K70.26967289
151TRPM70.26720302
152TYK20.26463285
153MAPKAPK50.25941085
154RPS6KL10.25329067
155RPS6KC10.25329067
156CDK70.24750394
157PRKCA0.23656755
158PRKG10.23314546
159TRIB30.23125394
160MAPK110.22950539
161RPS6KA40.20678904
162NUAK10.20618153

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001904.55830578
2* Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.51906506
3Parkinsons disease_Homo sapiens_hsa050124.03847946
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.55098673
5Propanoate metabolism_Homo sapiens_hsa006403.22294071
6Alzheimers disease_Homo sapiens_hsa050102.92302564
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.76000927
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72521173
9Cardiac muscle contraction_Homo sapiens_hsa042602.69078500
10* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.60803596
11Huntingtons disease_Homo sapiens_hsa050162.60053122
12Fatty acid degradation_Homo sapiens_hsa000712.59757202
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57915583
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51325263
15Pyruvate metabolism_Homo sapiens_hsa006202.47386328
16DNA replication_Homo sapiens_hsa030302.41671424
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27807069
18* Carbon metabolism_Homo sapiens_hsa012002.25419836
19Fatty acid elongation_Homo sapiens_hsa000622.22467824
20Butanoate metabolism_Homo sapiens_hsa006502.22328207
21Fatty acid metabolism_Homo sapiens_hsa012122.12900543
22Mismatch repair_Homo sapiens_hsa034302.09591808
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88400955
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83601316
25One carbon pool by folate_Homo sapiens_hsa006701.72064411
26Proteasome_Homo sapiens_hsa030501.70654839
27Peroxisome_Homo sapiens_hsa041461.60089617
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54792426
29Tryptophan metabolism_Homo sapiens_hsa003801.50931579
30Sulfur metabolism_Homo sapiens_hsa009201.42489197
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.35989136
32Biosynthesis of amino acids_Homo sapiens_hsa012301.35582850
33Homologous recombination_Homo sapiens_hsa034401.33347264
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31420944
35beta-Alanine metabolism_Homo sapiens_hsa004101.29233543
36Nucleotide excision repair_Homo sapiens_hsa034201.25659069
37Base excision repair_Homo sapiens_hsa034101.25622508
38Phenylalanine metabolism_Homo sapiens_hsa003601.25055748
39PPAR signaling pathway_Homo sapiens_hsa033201.23589783
40Arginine biosynthesis_Homo sapiens_hsa002201.22092613
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16900826
42Collecting duct acid secretion_Homo sapiens_hsa049661.15845928
43Spliceosome_Homo sapiens_hsa030401.15539599
44Tyrosine metabolism_Homo sapiens_hsa003501.13243374
45RNA transport_Homo sapiens_hsa030131.12363714
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.02329300
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02089236
48Non-homologous end-joining_Homo sapiens_hsa034500.95589185
49Arginine and proline metabolism_Homo sapiens_hsa003300.95399867
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94102271
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92568731
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90401908
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90400739
54Dilated cardiomyopathy_Homo sapiens_hsa054140.86589256
55* Metabolic pathways_Homo sapiens_hsa011000.85321162
56Starch and sucrose metabolism_Homo sapiens_hsa005000.85210652
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81682970
58RNA degradation_Homo sapiens_hsa030180.80633861
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78164172
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76870662
61Histidine metabolism_Homo sapiens_hsa003400.75180631
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74618172
63Chemical carcinogenesis_Homo sapiens_hsa052040.74565292
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74288620
65Glutathione metabolism_Homo sapiens_hsa004800.73574615
66Fructose and mannose metabolism_Homo sapiens_hsa000510.73465845
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67154523
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64617357
69Fat digestion and absorption_Homo sapiens_hsa049750.63791782
70Basal transcription factors_Homo sapiens_hsa030220.60850009
71Fanconi anemia pathway_Homo sapiens_hsa034600.59977895
72Pentose phosphate pathway_Homo sapiens_hsa000300.59221975
73Cell cycle_Homo sapiens_hsa041100.58649188
74Ribosome_Homo sapiens_hsa030100.57647652
75Folate biosynthesis_Homo sapiens_hsa007900.54514744
76Sulfur relay system_Homo sapiens_hsa041220.52563929
77Protein export_Homo sapiens_hsa030600.51972928
78Systemic lupus erythematosus_Homo sapiens_hsa053220.51174141
79Steroid biosynthesis_Homo sapiens_hsa001000.50371098
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.50064313
81Galactose metabolism_Homo sapiens_hsa000520.50033415
82Vibrio cholerae infection_Homo sapiens_hsa051100.49766417
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48421525
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46579092
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.42382494
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41947094
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41890394
88N-Glycan biosynthesis_Homo sapiens_hsa005100.40487483
89Glycerolipid metabolism_Homo sapiens_hsa005610.40224209
90Retinol metabolism_Homo sapiens_hsa008300.39931039
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.38910728
92Fatty acid biosynthesis_Homo sapiens_hsa000610.38038696
93Complement and coagulation cascades_Homo sapiens_hsa046100.36291739
94Bile secretion_Homo sapiens_hsa049760.35798643
95Caffeine metabolism_Homo sapiens_hsa002320.32226882
96Epstein-Barr virus infection_Homo sapiens_hsa051690.31974364
97Legionellosis_Homo sapiens_hsa051340.30956595
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29009628
99Selenocompound metabolism_Homo sapiens_hsa004500.27976707
100Glucagon signaling pathway_Homo sapiens_hsa049220.27583592
101Other glycan degradation_Homo sapiens_hsa005110.27548463
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24249674
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22919754
104Synaptic vesicle cycle_Homo sapiens_hsa047210.22649944
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.20401207
106RNA polymerase_Homo sapiens_hsa030200.20193648
107Oocyte meiosis_Homo sapiens_hsa041140.20092480
108Lysosome_Homo sapiens_hsa041420.17611566
109Vitamin B6 metabolism_Homo sapiens_hsa007500.16188958
110Mineral absorption_Homo sapiens_hsa049780.14699795
111Pyrimidine metabolism_Homo sapiens_hsa002400.11974664
112Vitamin digestion and absorption_Homo sapiens_hsa049770.11614029
113Purine metabolism_Homo sapiens_hsa002300.10434261
114Regulation of autophagy_Homo sapiens_hsa041400.09808167
115ABC transporters_Homo sapiens_hsa020100.09689003
116Calcium signaling pathway_Homo sapiens_hsa040200.08538265
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08001663
118Nitrogen metabolism_Homo sapiens_hsa009100.07989680
119Linoleic acid metabolism_Homo sapiens_hsa005910.07938473
120Rheumatoid arthritis_Homo sapiens_hsa053230.06344018
121Arachidonic acid metabolism_Homo sapiens_hsa005900.06265313
122Insulin signaling pathway_Homo sapiens_hsa049100.05308437
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.04779894
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.02902891
125Insulin resistance_Homo sapiens_hsa049310.02862603
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02031675
127Viral myocarditis_Homo sapiens_hsa054160.01477876

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