SDHCP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.06512803
2regulation of acrosome reaction (GO:0060046)6.82147013
3protein K11-linked deubiquitination (GO:0035871)5.85223491
4single strand break repair (GO:0000012)5.73510577
5nucleobase catabolic process (GO:0046113)5.51217363
6spermatid nucleus differentiation (GO:0007289)5.06516461
7positive regulation of amino acid transport (GO:0051957)4.87804232
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.64325138
9positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.56837490
10nerve growth factor signaling pathway (GO:0038180)4.23459475
11negative regulation of dendrite morphogenesis (GO:0050774)4.22282315
12inositol phosphate catabolic process (GO:0071545)4.17775560
13regulation of glycogen (starch) synthase activity (GO:2000465)4.05058065
14polyol catabolic process (GO:0046174)4.01167166
15positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.94379412
16anterograde synaptic vesicle transport (GO:0048490)3.79937078
17positive regulation of potassium ion transmembrane transport (GO:1901381)3.79900116
18limb bud formation (GO:0060174)3.78635601
19negative regulation of exocytosis (GO:0045920)3.73711791
20regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.64765454
21response to nerve growth factor (GO:1990089)3.59109360
22cellular response to nerve growth factor stimulus (GO:1990090)3.59109360
23atrial cardiac muscle cell action potential (GO:0086014)3.53561530
24response to methylmercury (GO:0051597)3.45742695
25transepithelial transport (GO:0070633)3.44831669
26regulation of glutamate secretion (GO:0014048)3.35190806
27inner ear receptor cell development (GO:0060119)3.34297317
28regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.31798765
29sulfate transport (GO:0008272)3.29596676
30termination of RNA polymerase III transcription (GO:0006386)3.21686894
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.21686894
32positive regulation of guanylate cyclase activity (GO:0031284)3.17806867
33retinal rod cell development (GO:0046548)3.16918999
34cerebral cortex radially oriented cell migration (GO:0021799)3.16190075
35DNA deamination (GO:0045006)3.15718004
36negative regulation of cell aging (GO:0090344)3.14823208
37adenosine metabolic process (GO:0046085)3.13105742
38negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10249532
39snRNA processing (GO:0016180)3.06706475
40DNA damage response, detection of DNA damage (GO:0042769)3.00398473
41spinal cord development (GO:0021510)2.97854184
42regulation of calcium ion-dependent exocytosis (GO:0017158)2.94146368
43regulation of cardiac muscle cell contraction (GO:0086004)2.94038993
44negative regulation of translation, ncRNA-mediated (GO:0040033)2.93970538
45regulation of translation, ncRNA-mediated (GO:0045974)2.93970538
46negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93970538
47glial cell proliferation (GO:0014009)2.88592695
48isoprenoid biosynthetic process (GO:0008299)2.87796440
49mitochondrion transport along microtubule (GO:0047497)2.85729556
50establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85729556
51neural tube formation (GO:0001841)2.85371204
52regulation of guanylate cyclase activity (GO:0031282)2.82970425
53lysosome organization (GO:0007040)2.82967095
54lytic vacuole organization (GO:0080171)2.82967095
55negative regulation of activin receptor signaling pathway (GO:0032926)2.77843921
56nephron tubule formation (GO:0072079)2.77658677
57adult feeding behavior (GO:0008343)2.77263743
58cornea development in camera-type eye (GO:0061303)2.76226791
59lateral ventricle development (GO:0021670)2.75700156
60snRNA metabolic process (GO:0016073)2.75093848
61kinetochore assembly (GO:0051382)2.73968001
62mitotic sister chromatid cohesion (GO:0007064)2.71149655
63pyrimidine-containing compound catabolic process (GO:0072529)2.68875987
64sulfate transmembrane transport (GO:1902358)2.68774365
65establishment of protein localization to vacuole (GO:0072666)2.67965746
66protein targeting to vacuole (GO:0006623)2.67965746
67protein targeting to lysosome (GO:0006622)2.67965746
68positive regulation of calcium-mediated signaling (GO:0050850)2.65846604
69sympathetic nervous system development (GO:0048485)2.64342982
70regulation of timing of cell differentiation (GO:0048505)2.62795107
71negative regulation of dendrite development (GO:2000171)2.61963838
72regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61490779
73pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.60553835
74UMP metabolic process (GO:0046049)2.60553835
75pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.60553835
76UMP biosynthetic process (GO:0006222)2.60553835
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58859988
78histone deubiquitination (GO:0016578)2.57673104
79cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.57449093
80establishment of mitochondrion localization (GO:0051654)2.57371231
81acrosome assembly (GO:0001675)2.57269427
82regulation of bile acid biosynthetic process (GO:0070857)2.55960651
83cellular response to sterol (GO:0036315)2.52621242
84positive regulation of oligodendrocyte differentiation (GO:0048714)2.51071130
85hindbrain development (GO:0030902)2.50460932
86anterograde axon cargo transport (GO:0008089)2.50223600
87rRNA methylation (GO:0031167)2.49958591
88positive regulation of actin filament depolymerization (GO:0030836)2.48243830
89lung vasculature development (GO:0060426)2.47815653
90generation of neurons (GO:0048699)2.45383262
91regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45223813
92mature B cell differentiation (GO:0002335)2.44499031
93response to amphetamine (GO:0001975)2.43741231
94negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.43529953
95multicellular organism reproduction (GO:0032504)2.42073433
96otic vesicle formation (GO:0030916)2.42035291
97early endosome to late endosome transport (GO:0045022)2.41814483
98positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.40483605
99negative regulation of calcium ion-dependent exocytosis (GO:0045955)10.7785063
100response to pheromone (GO:0019236)10.2298147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.72435882
2GBX2_23144817_ChIP-Seq_PC3_Human3.46657199
3EZH2_22144423_ChIP-Seq_EOC_Human3.10955150
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93343154
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82669086
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79022005
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36145801
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31107063
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26226155
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25700906
11EWS_26573619_Chip-Seq_HEK293_Human2.15360697
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.13048847
13IGF1R_20145208_ChIP-Seq_DFB_Human2.10485293
14P300_19829295_ChIP-Seq_ESCs_Human2.10005257
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09752930
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.05781323
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.96598028
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93671877
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92384156
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89777041
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86151408
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.84591847
23VDR_22108803_ChIP-Seq_LS180_Human1.83487033
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.78095584
25TP53_16413492_ChIP-PET_HCT116_Human1.76536919
26AR_21572438_ChIP-Seq_LNCaP_Human1.68101661
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66926268
28FUS_26573619_Chip-Seq_HEK293_Human1.66298694
29SMAD4_21799915_ChIP-Seq_A2780_Human1.63898708
30STAT3_23295773_ChIP-Seq_U87_Human1.58907476
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.58609680
32ELK1_19687146_ChIP-ChIP_HELA_Human1.54270392
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50821598
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49499478
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47767806
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46983892
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.46233870
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45499405
39TCF4_23295773_ChIP-Seq_U87_Human1.44941676
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44518074
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44421715
42AR_25329375_ChIP-Seq_VCAP_Human1.44354313
43TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.44030394
44KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43277162
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42262049
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38523583
47CBP_20019798_ChIP-Seq_JUKART_Human1.38523583
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37626768
49RUNX2_22187159_ChIP-Seq_PCA_Human1.33705092
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32536215
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31416173
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30483735
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.29851049
54HTT_18923047_ChIP-ChIP_STHdh_Human1.29766665
55AR_20517297_ChIP-Seq_VCAP_Human1.28433588
56TCF4_22108803_ChIP-Seq_LS180_Human1.27493977
57CDX2_22108803_ChIP-Seq_LS180_Human1.26083050
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.26010824
59RNF2_27304074_Chip-Seq_NSC_Mouse1.25212837
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23261303
61MYC_18940864_ChIP-ChIP_HL60_Human1.21630325
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21322198
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21216884
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21151122
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.20605970
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20525278
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.19687524
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17561765
69TP53_18474530_ChIP-ChIP_U2OS_Human1.17134073
70TAF15_26573619_Chip-Seq_HEK293_Human1.16774561
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16554567
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.16187538
73NCOR_22424771_ChIP-Seq_293T_Human1.15786501
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15320439
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15114820
76BCAT_22108803_ChIP-Seq_LS180_Human1.11632785
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.11113351
78KDM2B_26808549_Chip-Seq_REH_Human1.10972975
79AHR_22903824_ChIP-Seq_MCF-7_Human1.10207499
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09247495
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.09046583
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08586410
83ER_23166858_ChIP-Seq_MCF-7_Human1.08479720
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07649804
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07639650
86TP53_22573176_ChIP-Seq_HFKS_Human1.05921864
87VDR_23849224_ChIP-Seq_CD4+_Human1.05839934
88NANOG_19829295_ChIP-Seq_ESCs_Human1.04815480
89SOX2_19829295_ChIP-Seq_ESCs_Human1.04815480
90DROSHA_22980978_ChIP-Seq_HELA_Human1.04258628
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03226553
92ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02372469
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02060804
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02060804
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01232228
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01146955
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.00937815
98SOX9_26525672_Chip-Seq_HEART_Mouse1.00180011
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99611711
100GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.97412283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.77258579
2MP0010234_abnormal_vibrissa_follicle5.02947932
3MP0003183_abnormal_peptide_metabolism4.69712321
4MP0002102_abnormal_ear_morphology3.84141666
5MP0002163_abnormal_gland_morphology3.39357638
6MP0003787_abnormal_imprinting3.27625800
7MP0006072_abnormal_retinal_apoptosis3.22427581
8MP0008877_abnormal_DNA_methylation2.83808907
9MP0008872_abnormal_physiological_respon2.71844730
10MP0002638_abnormal_pupillary_reflex2.52149997
11MP0005551_abnormal_eye_electrophysiolog2.47149493
12MP0005253_abnormal_eye_physiology2.23471658
13MP0003195_calcinosis2.06596246
14MP0001984_abnormal_olfaction1.97108384
15MP0010678_abnormal_skin_adnexa1.96175421
16MP0008057_abnormal_DNA_replication1.93886010
17MP0002837_dystrophic_cardiac_calcinosis1.93564252
18MP0003880_abnormal_central_pattern1.92789958
19MP0005379_endocrine/exocrine_gland_phen1.89369906
20MP0000427_abnormal_hair_cycle1.81340766
21MP0002160_abnormal_reproductive_system1.81071745
22MP0002090_abnormal_vision1.78196270
23MP0009840_abnormal_foam_cell1.76582106
24MP0002938_white_spotting1.75659838
25MP0000015_abnormal_ear_pigmentation1.70335564
26MP0008058_abnormal_DNA_repair1.67941340
27MP0005174_abnormal_tail_pigmentation1.67459496
28MP0003123_paternal_imprinting1.65859924
29MP0005365_abnormal_bile_salt1.63389055
30MP0004043_abnormal_pH_regulation1.53571041
31MP0000372_irregular_coat_pigmentation1.53428454
32MP0002653_abnormal_ependyma_morphology1.48589217
33MP0005084_abnormal_gallbladder_morpholo1.46579404
34MP0003646_muscle_fatigue1.45575229
35MP0006276_abnormal_autonomic_nervous1.45203614
36MP0009745_abnormal_behavioral_response1.40302731
37MP0009046_muscle_twitch1.34303114
38MP0005220_abnormal_exocrine_pancreas1.29813996
39MP0005195_abnormal_posterior_eye1.27897294
40MP0004924_abnormal_behavior1.24465669
41MP0005386_behavior/neurological_phenoty1.24465669
42MP0000613_abnormal_salivary_gland1.21688876
43MP0000538_abnormal_urinary_bladder1.15980160
44MP0002735_abnormal_chemical_nociception1.15567542
45MP0005167_abnormal_blood-brain_barrier1.14620417
46MP0000778_abnormal_nervous_system1.13861689
47MP0003724_increased_susceptibility_to1.12439593
48MP0005391_vision/eye_phenotype1.12199490
49MP0001919_abnormal_reproductive_system1.11866401
50MP0003786_premature_aging1.09392242
51MP0002282_abnormal_trachea_morphology1.08621610
52MP0002229_neurodegeneration1.07476506
53MP0000516_abnormal_urinary_system1.03508170
54MP0005367_renal/urinary_system_phenotyp1.03508170
55MP0003137_abnormal_impulse_conducting1.02984854
56MP0008875_abnormal_xenobiotic_pharmacok1.02570941
57MP0001293_anophthalmia1.01072740
58MP0001501_abnormal_sleep_pattern1.00098925
59MP0005085_abnormal_gallbladder_physiolo0.99392472
60MP0001968_abnormal_touch/_nociception0.97427572
61MP0002736_abnormal_nociception_after0.96803527
62MP0002098_abnormal_vibrissa_morphology0.94045041
63MP0005646_abnormal_pituitary_gland0.93715952
64MP0002272_abnormal_nervous_system0.91631144
65MP0005360_urolithiasis0.90107336
66MP0002572_abnormal_emotion/affect_behav0.89101973
67MP0005075_abnormal_melanosome_morpholog0.88351292
68MP0001486_abnormal_startle_reflex0.88208373
69MP0004859_abnormal_synaptic_plasticity0.85487461
70MP0003045_fibrosis0.84874072
71MP0000383_abnormal_hair_follicle0.84033910
72MP0005389_reproductive_system_phenotype0.83880535
73MP0009780_abnormal_chondrocyte_physiolo0.81395125
74MP0002095_abnormal_skin_pigmentation0.80799727
75MP0003879_abnormal_hair_cell0.78948775
76MP0003635_abnormal_synaptic_transmissio0.78848326
77MP0003122_maternal_imprinting0.78543305
78MP0008995_early_reproductive_senescence0.78378370
79MP0004270_analgesia0.76419544
80MP0002064_seizures0.75242559
81MP0001986_abnormal_taste_sensitivity0.73272341
82MP0002557_abnormal_social/conspecific_i0.72987572
83MP0001970_abnormal_pain_threshold0.72193046
84MP0002928_abnormal_bile_duct0.71670241
85MP0005647_abnormal_sex_gland0.70366507
86MP0006054_spinal_hemorrhage0.69068224
87MP0002063_abnormal_learning/memory/cond0.67801273
88MP0002752_abnormal_somatic_nervous0.66115803
89MP0005410_abnormal_fertilization0.65486099
90MP0004142_abnormal_muscle_tone0.64473966
91MP0001944_abnormal_pancreas_morphology0.63481895
92MP0002882_abnormal_neuron_morphology0.63067500
93MP0005671_abnormal_response_to0.62253279
94MP0002876_abnormal_thyroid_physiology0.61175384
95MP0002733_abnormal_thermal_nociception0.60251997
96MP0004742_abnormal_vestibular_system0.59137540
97MP0001286_abnormal_eye_development0.58498461
98MP0008775_abnormal_heart_ventricle0.58327483
99MP0002751_abnormal_autonomic_nervous0.58307783
100MP0003121_genomic_imprinting0.56989034

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)5.38234353
2Carpal bone hypoplasia (HP:0001498)5.37667005
3Focal motor seizures (HP:0011153)5.29914478
4J-shaped sella turcica (HP:0002680)4.36267986
5Abnormality of the renal cortex (HP:0011035)3.93846656
63-Methylglutaconic aciduria (HP:0003535)3.85267263
7Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.63554248
8Abnormality of macular pigmentation (HP:0008002)3.52444025
9Aortic regurgitation (HP:0001659)3.48366894
10Abnormal hair laboratory examination (HP:0003328)3.20245759
11Hip dysplasia (HP:0001385)3.11930874
12Abnormality of small intestinal villus morphology (HP:0011472)3.11540991
13Villous atrophy (HP:0011473)3.11540991
14Pendular nystagmus (HP:0012043)3.07588718
15Hypoplastic pelvis (HP:0008839)3.06737332
16Conjugated hyperbilirubinemia (HP:0002908)2.98422052
17Morphological abnormality of the middle ear (HP:0008609)2.97880907
18Curly hair (HP:0002212)2.96557163
19Broad alveolar ridges (HP:0000187)2.94723086
20Abnormality of methionine metabolism (HP:0010901)2.88368834
21Brittle hair (HP:0002299)2.84498914
22Fibular aplasia (HP:0002990)2.78694077
23Lissencephaly (HP:0001339)2.69209902
24Bilateral microphthalmos (HP:0007633)2.64455872
25Diastasis recti (HP:0001540)2.62900762
26Thoracic kyphosis (HP:0002942)2.56046553
27Abnormality of aspartate family amino acid metabolism (HP:0010899)2.53889419
28Sensory axonal neuropathy (HP:0003390)2.53410162
29Abnormal albumin level (HP:0012116)2.51130106
30Hypoalbuminemia (HP:0003073)2.51130106
31Broad ribs (HP:0000885)2.50385592
32Methylmalonic aciduria (HP:0012120)2.49430453
33Focal seizures (HP:0007359)2.47630099
34Cupped ear (HP:0000378)2.47042034
35Fair hair (HP:0002286)2.45128064
36Thyroiditis (HP:0100646)2.44922813
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.39952353
38Vertebral arch anomaly (HP:0008438)2.39838319
39Severe combined immunodeficiency (HP:0004430)2.38170992
40Abnormality of liposaccharide metabolism (HP:0010968)2.37628497
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.37628497
42Abnormality of glycolipid metabolism (HP:0010969)2.37628497
43Beaking of vertebral bodies (HP:0004568)2.36577840
44Abnormality of the lumbar spine (HP:0100712)2.36498602
45Type II lissencephaly (HP:0007260)2.35596649
46Wide intermamillary distance (HP:0006610)2.31729597
47Bicornuate uterus (HP:0000813)2.27469822
48Febrile seizures (HP:0002373)2.26638833
49Aplasia/Hypoplasia involving the musculature (HP:0001460)2.24755192
50Thoracolumbar scoliosis (HP:0002944)2.23180614
51Birth length less than 3rd percentile (HP:0003561)2.22072180
52Aplasia/hypoplasia of the uterus (HP:0008684)2.21906559
53Absent eyebrow (HP:0002223)2.21365865
54Delayed CNS myelination (HP:0002188)2.20633514
55Neoplasm of the adrenal cortex (HP:0100641)2.20005923
56Anophthalmia (HP:0000528)2.18646715
57Pancreatic cysts (HP:0001737)2.18021271
58Abnormality of the pubic bones (HP:0003172)2.15808580
59Ketoacidosis (HP:0001993)2.10327370
60Thickened calvaria (HP:0002684)2.09579844
61Azoospermia (HP:0000027)2.07905117
62Bifid tongue (HP:0010297)2.06635009
63Long clavicles (HP:0000890)2.06420860
64Thrombocytosis (HP:0001894)2.05654081
65Cerebellar dysplasia (HP:0007033)2.05016052
66Woolly hair (HP:0002224)2.03536565
67Renal hypoplasia (HP:0000089)2.03125476
68Enlarged penis (HP:0000040)2.02987856
69Abnormal lung lobation (HP:0002101)2.00199353
70Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98931170
71Severe visual impairment (HP:0001141)1.96686090
72Flared iliac wings (HP:0002869)1.94367754
73Pachygyria (HP:0001302)1.90808265
74Inability to walk (HP:0002540)1.89602986
75Intestinal atresia (HP:0011100)1.87623302
76Tetany (HP:0001281)1.86558839
77Severe Myopia (HP:0011003)1.84908917
78Abnormality of the thoracic spine (HP:0100711)1.83906501
79Myokymia (HP:0002411)1.83432334
80Neuroendocrine neoplasm (HP:0100634)1.79936947
81Attenuation of retinal blood vessels (HP:0007843)1.78759265
82Abnormality of iron homeostasis (HP:0011031)1.77586940
83Amyotrophic lateral sclerosis (HP:0007354)1.77315725
84Progressive inability to walk (HP:0002505)1.76321402
85Arthropathy (HP:0003040)1.75169491
86Hypoplastic iliac wings (HP:0002866)1.74889266
87Abnormal spermatogenesis (HP:0008669)1.74780340
88Nephronophthisis (HP:0000090)1.74360503
89Palpebral edema (HP:0100540)1.73539693
90Constricted visual fields (HP:0001133)1.72897456
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72514314
92Meningioma (HP:0002858)1.72215378
93Deformed sella turcica (HP:0002681)1.71602071
94Pheochromocytoma (HP:0002666)1.71493348
95Dialeptic seizures (HP:0011146)1.70145479
96Pancreatic fibrosis (HP:0100732)1.65980087
97Panhypogammaglobulinemia (HP:0003139)1.65954886
98Postnatal growth retardation (HP:0008897)1.65870587
99Microtia (HP:0008551)1.65740801
100Abnormality of the alveolar ridges (HP:0006477)1.65683491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.12327999
2LATS14.53749202
3MARK14.06800983
4NUAK13.55208298
5CAMKK23.52279931
6EPHA43.34474918
7MST43.33360249
8SRPK13.17965301
9DYRK33.13140446
10INSRR2.79587503
11PNCK2.58287576
12STK38L2.11930478
13TESK22.08389001
14WNK31.84319401
15CASK1.82638100
16MAP2K61.79516539
17MAP4K21.65047182
18NTRK31.63552891
19YES11.59483076
20FGFR21.50669233
21DYRK21.46818633
22LIMK11.39979240
23STK161.39588411
24TAOK31.37343877
25CAMK1G1.25145101
26NLK1.19706481
27CAMKK11.08526879
28CAMK11.07655485
29CDK31.07576033
30BMPR1B1.07439138
31MINK11.05298321
32STK30.99992245
33ACVR1B0.99362000
34MAPK130.99225432
35TNIK0.98670011
36STK390.97229730
37MAP3K100.97192512
38PRKD30.94702428
39CAMK40.89979312
40NTRK10.88425094
41ROCK10.87943894
42ZAK0.84505304
43DYRK1A0.83950390
44STK240.83714506
45OXSR10.78980712
46PLK40.73837925
47EPHA20.71179958
48BCR0.71169786
49MATK0.70926731
50PHKG20.69730326
51PHKG10.69730326
52STK380.68021075
53PAK30.66889700
54PTK2B0.66008047
55GRK10.65878795
56MAP3K40.65685110
57TRIM280.61012364
58ADRBK20.60375994
59TYRO30.60209827
60MAP2K70.58518523
61TAOK10.56598215
62FER0.56578157
63PASK0.50745571
64FLT30.50304409
65ROCK20.49692968
66CCNB10.49296675
67VRK10.48055102
68BRSK20.47584188
69PLK30.46690116
70SCYL20.44248640
71ATM0.42424977
72IKBKB0.40267119
73STK110.37561560
74TLK10.35632773
75TEC0.35605519
76PRKCE0.35586337
77ADRBK10.34444716
78FGR0.33786521
79ZAP700.33424599
80ABL10.32941387
81ERBB20.32405290
82CDK50.32065520
83PRKCQ0.31764552
84KSR10.31637999
85CAMK2A0.30646580
86TGFBR10.28520677
87MAP3K120.28144501
88RPS6KA40.26834802
89NME10.26139671
90PINK10.22046282
91PRKCZ0.21812090
92GSK3A0.21735940
93MAPK80.21624892
94CHEK20.20313088
95CSF1R0.20146454
96PRKCG0.19369186
97GRK50.18997642
98FGFR30.18709297
99CSNK1A10.15377760
100PRKACB0.14198644

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.83177506
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.21438110
3Protein export_Homo sapiens_hsa030603.09103810
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.81748080
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.79303712
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.62532821
7RNA polymerase_Homo sapiens_hsa030202.57682355
8Steroid biosynthesis_Homo sapiens_hsa001002.53939686
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07557311
10Butanoate metabolism_Homo sapiens_hsa006501.98092831
11Circadian rhythm_Homo sapiens_hsa047101.94608475
12RNA degradation_Homo sapiens_hsa030181.86338644
13Taste transduction_Homo sapiens_hsa047421.81774586
14Primary immunodeficiency_Homo sapiens_hsa053401.76771529
15Amphetamine addiction_Homo sapiens_hsa050311.72315809
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62980833
17Nicotine addiction_Homo sapiens_hsa050331.61998805
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57355977
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56510301
20Fanconi anemia pathway_Homo sapiens_hsa034601.54026528
21Olfactory transduction_Homo sapiens_hsa047401.51811744
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.49110038
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48795474
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47068934
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42593896
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42548504
27Mismatch repair_Homo sapiens_hsa034301.41879270
28Oxidative phosphorylation_Homo sapiens_hsa001901.39817228
29Caffeine metabolism_Homo sapiens_hsa002321.36880264
30Parkinsons disease_Homo sapiens_hsa050121.33405659
31Linoleic acid metabolism_Homo sapiens_hsa005911.32544326
32Cocaine addiction_Homo sapiens_hsa050301.27072325
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.23828703
34Collecting duct acid secretion_Homo sapiens_hsa049661.12016263
35Dopaminergic synapse_Homo sapiens_hsa047281.10668929
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09401453
37Axon guidance_Homo sapiens_hsa043601.08479446
38Morphine addiction_Homo sapiens_hsa050321.06272104
39Ovarian steroidogenesis_Homo sapiens_hsa049131.05628447
40Homologous recombination_Homo sapiens_hsa034401.05627217
41Folate biosynthesis_Homo sapiens_hsa007901.05152675
42Propanoate metabolism_Homo sapiens_hsa006401.03841625
43Glutamatergic synapse_Homo sapiens_hsa047240.99038818
44Regulation of autophagy_Homo sapiens_hsa041400.99032772
45Nitrogen metabolism_Homo sapiens_hsa009100.98551408
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96939526
47T cell receptor signaling pathway_Homo sapiens_hsa046600.93767897
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89433065
49Insulin secretion_Homo sapiens_hsa049110.88051193
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86564186
51GABAergic synapse_Homo sapiens_hsa047270.78189835
52Renin secretion_Homo sapiens_hsa049240.78035609
53Ether lipid metabolism_Homo sapiens_hsa005650.77974501
54cAMP signaling pathway_Homo sapiens_hsa040240.77163000
55Wnt signaling pathway_Homo sapiens_hsa043100.77121938
56Dorso-ventral axis formation_Homo sapiens_hsa043200.76671770
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75967771
58Fatty acid metabolism_Homo sapiens_hsa012120.75465086
59Huntingtons disease_Homo sapiens_hsa050160.75410992
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.75409579
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74952840
62Basal transcription factors_Homo sapiens_hsa030220.74635833
63Thyroid cancer_Homo sapiens_hsa052160.74516825
64Selenocompound metabolism_Homo sapiens_hsa004500.74320661
65Lysosome_Homo sapiens_hsa041420.72886387
66Chemical carcinogenesis_Homo sapiens_hsa052040.71636042
67Tryptophan metabolism_Homo sapiens_hsa003800.70966559
68Circadian entrainment_Homo sapiens_hsa047130.65691113
69Pyrimidine metabolism_Homo sapiens_hsa002400.65155354
70Calcium signaling pathway_Homo sapiens_hsa040200.64908334
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61215807
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60707020
73Purine metabolism_Homo sapiens_hsa002300.59517139
74Proteasome_Homo sapiens_hsa030500.59483070
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59194386
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58840322
77Ras signaling pathway_Homo sapiens_hsa040140.57908561
78One carbon pool by folate_Homo sapiens_hsa006700.56882174
79Fatty acid elongation_Homo sapiens_hsa000620.54855093
80ABC transporters_Homo sapiens_hsa020100.52953638
81Peroxisome_Homo sapiens_hsa041460.52682219
82Bile secretion_Homo sapiens_hsa049760.50147129
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49896541
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46533915
85Alzheimers disease_Homo sapiens_hsa050100.46197554
86Retinol metabolism_Homo sapiens_hsa008300.43916614
87Serotonergic synapse_Homo sapiens_hsa047260.38263325
88Ribosome_Homo sapiens_hsa030100.37665254
89Salivary secretion_Homo sapiens_hsa049700.36608938
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36534157
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.35093455
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.34950866
93Spliceosome_Homo sapiens_hsa030400.34094802
94Mineral absorption_Homo sapiens_hsa049780.32897078
95MAPK signaling pathway_Homo sapiens_hsa040100.32664588
96Hedgehog signaling pathway_Homo sapiens_hsa043400.32612428
97Glutathione metabolism_Homo sapiens_hsa004800.31365747
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31030602
99Long-term potentiation_Homo sapiens_hsa047200.30292898
100Cholinergic synapse_Homo sapiens_hsa047250.30137756

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