SDHD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.29441486
2* tricarboxylic acid cycle (GO:0006099)5.98240712
3ATP synthesis coupled proton transport (GO:0015986)5.73848624
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.73848624
5proteasome assembly (GO:0043248)5.66539375
6lysine catabolic process (GO:0006554)5.41467142
7lysine metabolic process (GO:0006553)5.41467142
8oxidative phosphorylation (GO:0006119)5.15077818
9* respiratory electron transport chain (GO:0022904)4.93676135
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.81352147
11* electron transport chain (GO:0022900)4.79890803
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.77328128
13L-phenylalanine catabolic process (GO:0006559)4.77328128
14NADH metabolic process (GO:0006734)4.75594449
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.71330322
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.67318895
17L-phenylalanine metabolic process (GO:0006558)4.67318895
18glyoxylate metabolic process (GO:0046487)4.65632207
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.49893909
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.49559034
21succinate metabolic process (GO:0006105)4.48422950
22regulation of cellular amino acid metabolic process (GO:0006521)4.48345397
23fatty acid beta-oxidation (GO:0006635)4.42557070
24negative regulation of ligase activity (GO:0051352)4.37114316
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.37114316
26establishment of protein localization to mitochondrial membrane (GO:0090151)4.31201241
27oxaloacetate metabolic process (GO:0006107)4.29711485
28respiratory chain complex IV assembly (GO:0008535)4.27860370
292-oxoglutarate metabolic process (GO:0006103)4.26347179
30cellular ketone body metabolic process (GO:0046950)4.25632850
31branched-chain amino acid catabolic process (GO:0009083)4.25176098
32aspartate family amino acid catabolic process (GO:0009068)4.25064377
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.20062753
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.11785447
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.11785447
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.11785447
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.11051446
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.11051446
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.10226696
40ribosome assembly (GO:0042255)4.07865207
41aromatic amino acid family catabolic process (GO:0009074)4.03859848
42acetyl-CoA metabolic process (GO:0006084)3.97048438
43fatty acid oxidation (GO:0019395)3.95592837
44chaperone-mediated protein transport (GO:0072321)3.94916868
45fatty acid catabolic process (GO:0009062)3.94420739
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.93497032
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.93497032
48aldehyde catabolic process (GO:0046185)3.92104904
49regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.91692221
50tricarboxylic acid metabolic process (GO:0072350)3.91171563
51lipid oxidation (GO:0034440)3.90115726
52branched-chain amino acid metabolic process (GO:0009081)3.88473735
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.85425144
54valine metabolic process (GO:0006573)3.84833963
55carnitine shuttle (GO:0006853)3.82764224
56positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.82582424
57fatty acid transmembrane transport (GO:1902001)3.79100380
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.78851938
59cytochrome complex assembly (GO:0017004)3.77749710
60kynurenine metabolic process (GO:0070189)3.77383067
61establishment of integrated proviral latency (GO:0075713)3.76104963
62positive regulation of ligase activity (GO:0051351)3.71744743
63short-chain fatty acid metabolic process (GO:0046459)3.71115726
64ketone body metabolic process (GO:1902224)3.70773522
65amino-acid betaine metabolic process (GO:0006577)3.69645358
66heart contraction (GO:0060047)3.66275029
67heart process (GO:0003015)3.66275029
68IMP biosynthetic process (GO:0006188)3.65764039
69protein complex biogenesis (GO:0070271)3.65656520
70triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.64466876
71regulation of acyl-CoA biosynthetic process (GO:0050812)3.63767057
72ATP biosynthetic process (GO:0006754)3.62031743
73mitochondrial respiratory chain complex assembly (GO:0033108)3.61216624
74monocarboxylic acid catabolic process (GO:0072329)3.60121962
75carnitine metabolic process (GO:0009437)3.58871998
76cysteine metabolic process (GO:0006534)3.57279683
77regulation of triglyceride catabolic process (GO:0010896)3.55383653
78alpha-linolenic acid metabolic process (GO:0036109)3.53027377
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.52050257
80water-soluble vitamin biosynthetic process (GO:0042364)3.51331360
81purine nucleobase biosynthetic process (GO:0009113)3.50785217
82rRNA modification (GO:0000154)3.50410224
83tryptophan catabolic process (GO:0006569)3.48616436
84indole-containing compound catabolic process (GO:0042436)3.48616436
85indolalkylamine catabolic process (GO:0046218)3.48616436
86cullin deneddylation (GO:0010388)3.47412250
87regulation of coenzyme metabolic process (GO:0051196)3.43890502
88regulation of cofactor metabolic process (GO:0051193)3.43890502
89regulation of ubiquitin-protein transferase activity (GO:0051438)3.43273903
90termination of RNA polymerase III transcription (GO:0006386)3.36617341
91transcription elongation from RNA polymerase III promoter (GO:0006385)3.36617341
92regulation of ligase activity (GO:0051340)3.35893657
93aerobic respiration (GO:0009060)3.35146509
94tryptophan metabolic process (GO:0006568)3.34774838
95sulfur amino acid catabolic process (GO:0000098)3.34321103
96protein neddylation (GO:0045116)3.32767687
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.32190590
98bile acid biosynthetic process (GO:0006699)3.31510334
99IMP metabolic process (GO:0046040)3.31478582
100sarcomere organization (GO:0045214)3.28481108
101protein deneddylation (GO:0000338)3.26709933
102alpha-amino acid catabolic process (GO:1901606)3.26196441
103regulation of cellular amine metabolic process (GO:0033238)3.23221214
104regulation of sequestering of triglyceride (GO:0010889)3.23046802
105organic acid catabolic process (GO:0016054)3.19387934
106carboxylic acid catabolic process (GO:0046395)3.19387934
107protein targeting to mitochondrion (GO:0006626)3.17564814
108muscle filament sliding (GO:0030049)3.17248921
109actin-myosin filament sliding (GO:0033275)3.17248921
110regulation of mitochondrial translation (GO:0070129)3.16355549
111AMP metabolic process (GO:0046033)3.14503519
112cellular amino acid catabolic process (GO:0009063)3.13593929
113quinone biosynthetic process (GO:1901663)3.13580175
114ubiquinone biosynthetic process (GO:0006744)3.13580175
115nucleobase biosynthetic process (GO:0046112)3.12946227
116establishment of viral latency (GO:0019043)3.12823674
117ethanol oxidation (GO:0006069)3.12675863
118NAD metabolic process (GO:0019674)3.12333247
119negative regulation of protein ubiquitination (GO:0031397)3.11742891
120acyl-CoA metabolic process (GO:0006637)3.11518612
121thioester metabolic process (GO:0035383)3.11518612
122purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10283279
123positive regulation of cell cycle arrest (GO:0071158)3.09857568
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08283648
125nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08221815
126rRNA methylation (GO:0031167)3.07992083
127carnitine transport (GO:0015879)3.07975316
128amino-acid betaine transport (GO:0015838)3.07975316
129pteridine-containing compound biosynthetic process (GO:0042559)3.07920174
130ribosomal large subunit biogenesis (GO:0042273)3.07337574
131carnitine transmembrane transport (GO:1902603)3.05830516
132DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.02824967
133cellular respiration (GO:0045333)3.02702952
134inner mitochondrial membrane organization (GO:0007007)3.01634773
135purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.00778003
136biotin metabolic process (GO:0006768)3.00463168
137CENP-A containing nucleosome assembly (GO:0034080)3.00428029
138DNA catabolic process, exonucleolytic (GO:0000738)2.99723164
139urea cycle (GO:0000050)2.99288145
140urea metabolic process (GO:0019627)2.99288145
141aromatic amino acid family metabolic process (GO:0009072)2.98692761
142pseudouridine synthesis (GO:0001522)2.97974435
143chromatin remodeling at centromere (GO:0031055)2.95681417
144DNA double-strand break processing (GO:0000729)2.95463885
145coenzyme catabolic process (GO:0009109)2.94346676
146protein localization to mitochondrion (GO:0070585)2.93873823
147purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.93491775
148purine nucleoside monophosphate biosynthetic process (GO:0009127)2.93491775
149serine family amino acid catabolic process (GO:0009071)2.93261984
150maturation of 5.8S rRNA (GO:0000460)2.92595221
151DNA deamination (GO:0045006)2.91432619
152negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.91205630
153response to mercury ion (GO:0046689)2.91137736
154dicarboxylic acid metabolic process (GO:0043648)2.88182179
155mitochondrial respiratory chain complex I assembly (GO:0032981)2.87623214
156NADH dehydrogenase complex assembly (GO:0010257)2.87623214
157mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87623214
158establishment of protein localization to mitochondrion (GO:0072655)2.87136059
159acylglycerol homeostasis (GO:0055090)2.86623962
160triglyceride homeostasis (GO:0070328)2.86623962
161ubiquinone metabolic process (GO:0006743)2.86024647
162homocysteine metabolic process (GO:0050667)2.85945386
163regulation of fatty acid oxidation (GO:0046320)2.85694885
164telomere maintenance via semi-conservative replication (GO:0032201)2.84952473
165cofactor catabolic process (GO:0051187)2.84651697
166thioester biosynthetic process (GO:0035384)2.84307278
167mitochondrial transport (GO:0006839)2.82195499
168lactate metabolic process (GO:0006089)2.76041612
169antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.75718558
170G1/S transition of mitotic cell cycle (GO:0000082)2.73285199
171cell cycle G1/S phase transition (GO:0044843)2.73285199
172folic acid-containing compound biosynthetic process (GO:0009396)2.73086056
173hydrogen ion transmembrane transport (GO:1902600)2.71976647
174transcription from mitochondrial promoter (GO:0006390)2.69028187
175peptidyl-histidine modification (GO:0018202)2.68519755
176DNA strand elongation involved in DNA replication (GO:0006271)2.65293405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.37884879
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.89710148
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.74554393
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.33597733
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.64271904
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57538084
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.50372119
8* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.49843951
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49788337
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.36981889
11E2F7_22180533_ChIP-Seq_HELA_Human3.20099939
12* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.06335592
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.88982840
14* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.80884516
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.74181053
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65359795
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61285367
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48836215
19* GABP_17652178_ChIP-ChIP_JURKAT_Human2.47208439
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.39667966
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.36763358
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.34282201
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22365840
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11546528
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.04062595
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92472844
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92375611
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90903370
29* ETS1_20019798_ChIP-Seq_JURKAT_Human1.86463793
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82569038
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80959928
32GATA1_22025678_ChIP-Seq_K562_Human1.71677773
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69204741
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68545675
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66272526
36CLOCK_20551151_ChIP-Seq_293T_Human1.65248274
37VDR_22108803_ChIP-Seq_LS180_Human1.58526669
38DCP1A_22483619_ChIP-Seq_HELA_Human1.55645487
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.54607245
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46457049
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46324623
42BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43071725
43* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.42228619
44* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40674596
45TTF2_22483619_ChIP-Seq_HELA_Human1.38302156
46* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36689828
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34802144
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31236700
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30392094
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30183768
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28671405
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24784202
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24182110
54* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21107009
55VDR_23849224_ChIP-Seq_CD4+_Human1.20651904
56* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20369583
57GABP_19822575_ChIP-Seq_HepG2_Human1.19905611
58GATA4_21415370_ChIP-Seq_HL-1_Mouse1.19680342
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17399328
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17117505
61* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15799602
62MYC_18940864_ChIP-ChIP_HL60_Human1.14230216
63TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13087662
64FOXP3_21729870_ChIP-Seq_TREG_Human1.12984521
65AR_21909140_ChIP-Seq_LNCAP_Human1.12873611
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11575918
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.06793789
68* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06620450
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04804376
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02945911
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02824037
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01524421
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.01520618
74XRN2_22483619_ChIP-Seq_HELA_Human1.01498980
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01441236
76ELK1_19687146_ChIP-ChIP_HELA_Human1.00530037
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00339366
78HTT_18923047_ChIP-ChIP_STHdh_Human0.99514498
79RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99463073
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98670619
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97797204
82E2F1_21310950_ChIP-Seq_MCF-7_Human0.97724894
83TFEB_21752829_ChIP-Seq_HELA_Human0.97107224
84EWS_26573619_Chip-Seq_HEK293_Human0.95726126
85NANOG_16153702_ChIP-ChIP_HESCs_Human0.92305559
86* ELF5_23300383_ChIP-Seq_T47D_Human0.90649502
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.90445039
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.90366987
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90064573
90* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89337014
91TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89174141
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89167160
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88663015
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88048442
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86369865
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86144984
97ZNF274_21170338_ChIP-Seq_K562_Hela0.85712156
98AR_20517297_ChIP-Seq_VCAP_Human0.84620043
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83978231
100MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.82307086
101IRF8_22096565_ChIP-ChIP_GC-B_Human0.81609710
102TBX20_22328084_ChIP-Seq_HEART_Mouse0.80239854
103TBX20_22080862_ChIP-Seq_HEART_Mouse0.80239854
104* NANOG_19829295_ChIP-Seq_ESCs_Human0.79750992
105* SOX2_19829295_ChIP-Seq_ESCs_Human0.79750992
106EZH2_27294783_Chip-Seq_NPCs_Mouse0.79602794
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79205443
108ERG_20517297_ChIP-Seq_VCAP_Human0.78882209
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.78739240
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78445651
111HNF4A_19822575_ChIP-Seq_HepG2_Human0.78139319
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78049707
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.77593941
114FOXM1_23109430_ChIP-Seq_U2OS_Human0.77012918
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76930794
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76571546
117* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.76556123
118GATA4_25053715_ChIP-Seq_YYC3_Human0.75940723
119FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75808655
120FOXA1_25329375_ChIP-Seq_VCAP_Human0.75808655
121FUS_26573619_Chip-Seq_HEK293_Human0.75619349
122* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75130458
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75060377
124ZNF263_19887448_ChIP-Seq_K562_Human0.73353485
125* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.72648145
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70256582
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.68946072
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.68870350
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.66114806
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65882415
131MYCN_18555785_ChIP-Seq_MESCs_Mouse0.65546186
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65490278
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.65413359
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.64963464
135RXRA_24833708_ChIP-Seq_LIVER_Mouse0.64637984
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.64239512
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.63313189
138* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.63247589
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.62407496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.44108708
2MP0005360_urolithiasis5.29243188
3MP0003806_abnormal_nucleotide_metabolis4.92877419
4MP0002837_dystrophic_cardiac_calcinosis4.29020569
5MP0005085_abnormal_gallbladder_physiolo4.18603261
6MP0005365_abnormal_bile_salt3.82350126
7MP0008875_abnormal_xenobiotic_pharmacok3.20241911
8MP0003646_muscle_fatigue3.18150072
9MP0008058_abnormal_DNA_repair3.10054446
10* MP0006036_abnormal_mitochondrial_physio3.02989354
11MP0004084_abnormal_cardiac_muscle2.83961711
12MP0010094_abnormal_chromosome_stability2.78183599
13MP0004957_abnormal_blastocyst_morpholog2.73473105
14MP0003693_abnormal_embryo_hatching2.71676717
15MP0005332_abnormal_amino_acid2.69170067
16MP0003195_calcinosis2.67683470
17MP0000749_muscle_degeneration2.47261057
18MP0004215_abnormal_myocardial_fiber2.38431943
19MP0005330_cardiomyopathy2.37765347
20MP0004036_abnormal_muscle_relaxation2.36182521
21MP0003186_abnormal_redox_activity2.32914966
22MP0010329_abnormal_lipoprotein_level2.32028849
23MP0003718_maternal_effect2.30062037
24MP0003252_abnormal_bile_duct2.15759755
25MP0003941_abnormal_skin_development2.12991036
26MP0008007_abnormal_cellular_replicative2.04070856
27MP0005083_abnormal_biliary_tract2.02366062
28MP0003786_premature_aging1.98088841
29MP0009840_abnormal_foam_cell1.97501131
30MP0006035_abnormal_mitochondrial_morpho1.96065150
31MP0000751_myopathy1.94201066
32MP0004043_abnormal_pH_regulation1.90749040
33MP0001666_abnormal_nutrient_absorption1.89900538
34MP0004130_abnormal_muscle_cell1.85118730
35MP0002254_reproductive_system_inflammat1.83839222
36MP0005319_abnormal_enzyme/_coenzyme1.83236711
37MP0003111_abnormal_nucleus_morphology1.81682534
38MP0001764_abnormal_homeostasis1.80939770
39MP0002972_abnormal_cardiac_muscle1.77474506
40MP0005584_abnormal_enzyme/coenzyme_acti1.71510276
41MP0008775_abnormal_heart_ventricle1.66567697
42MP0003656_abnormal_erythrocyte_physiolo1.65748706
43MP0002118_abnormal_lipid_homeostasis1.64693225
44MP0009643_abnormal_urine_homeostasis1.63717122
45MP0003077_abnormal_cell_cycle1.61312759
46MP0003221_abnormal_cardiomyocyte_apopto1.59229054
47MP0000372_irregular_coat_pigmentation1.59040050
48MP0004147_increased_porphyrin_level1.56465417
49MP0002269_muscular_atrophy1.56367018
50MP0005451_abnormal_body_composition1.54228837
51MP0003191_abnormal_cellular_cholesterol1.52557484
52MP0000609_abnormal_liver_physiology1.52321459
53MP0004087_abnormal_muscle_fiber1.50191045
54MP0005266_abnormal_metabolism1.47492788
55MP0005620_abnormal_muscle_contractility1.46075004
56MP0005670_abnormal_white_adipose1.41307789
57* MP0005385_cardiovascular_system_phenoty1.40301893
58* MP0001544_abnormal_cardiovascular_syste1.40301893
59MP0008932_abnormal_embryonic_tissue1.40280474
60MP0005636_abnormal_mineral_homeostasis1.35546725
61MP0009697_abnormal_copulation1.32512168
62MP0002138_abnormal_hepatobiliary_system1.30816560
63MP0004019_abnormal_vitamin_homeostasis1.28199914
64MP0008057_abnormal_DNA_replication1.22597139
65MP0003011_delayed_dark_adaptation1.22405001
66MP0006138_congestive_heart_failure1.19490003
67MP0010630_abnormal_cardiac_muscle1.17769071
68MP0008872_abnormal_physiological_respon1.17471206
69MP0009785_altered_susceptibility_to1.16981252
70MP0005666_abnormal_adipose_tissue1.15408386
71MP0000750_abnormal_muscle_regeneration1.13389941
72MP0003137_abnormal_impulse_conducting1.12938817
73MP0005535_abnormal_body_temperature1.12134561
74MP0002106_abnormal_muscle_physiology1.11743668
75MP0005376_homeostasis/metabolism_phenot1.11494730
76MP0006072_abnormal_retinal_apoptosis1.11000114
77MP0002102_abnormal_ear_morphology1.10187608
78MP0002277_abnormal_respiratory_mucosa1.09442241
79MP0010234_abnormal_vibrissa_follicle1.08554353
80MP0002078_abnormal_glucose_homeostasis1.08365070
81MP0000747_muscle_weakness1.08122285
82MP0002971_abnormal_brown_adipose1.07009418
83MP0005379_endocrine/exocrine_gland_phen1.06582422
84MP0001756_abnormal_urination1.05513016
85MP0009333_abnormal_splenocyte_physiolog1.04596652
86MP0002148_abnormal_hypersensitivity_rea1.04058259
87MP0002876_abnormal_thyroid_physiology0.99171466
88MP0002332_abnormal_exercise_endurance0.98376087
89MP0002006_tumorigenesis0.97038218
90MP0008877_abnormal_DNA_methylation0.95006581
91MP0005408_hypopigmentation0.94796715
92MP0004484_altered_response_of0.94754751
93MP0001661_extended_life_span0.94698281
94MP0000230_abnormal_systemic_arterial0.94343406
95MP0000598_abnormal_liver_morphology0.91395604
96MP0005075_abnormal_melanosome_morpholog0.90081725
97MP0000343_altered_response_to0.89256547
98MP0002938_white_spotting0.88960421
99MP0006054_spinal_hemorrhage0.88899284
100MP0005395_other_phenotype0.88767039
101MP0002166_altered_tumor_susceptibility0.88161847
102MP0005084_abnormal_gallbladder_morpholo0.87993302
103MP0010352_gastrointestinal_tract_polyps0.86245358
104MP0006082_CNS_inflammation0.85175403
105MP0004085_abnormal_heartbeat0.84373308
106MP0005369_muscle_phenotype0.82431424
107MP0000759_abnormal_skeletal_muscle0.79789460
108MP0005671_abnormal_response_to0.79729953
109MP0009642_abnormal_blood_homeostasis0.79613171
110MP0002090_abnormal_vision0.79444819
111MP0008469_abnormal_protein_level0.78821548
112MP0002163_abnormal_gland_morphology0.74815913
113MP0002127_abnormal_cardiovascular_syste0.74628702
114MP0008873_increased_physiological_sensi0.73883024
115MP0005166_decreased_susceptibility_to0.73104080
116MP0001881_abnormal_mammary_gland0.72324502
117MP0005058_abnormal_lysosome_morphology0.69819376
118MP0009763_increased_sensitivity_to0.69278233
119MP0000516_abnormal_urinary_system0.67319820
120MP0005367_renal/urinary_system_phenotyp0.67319820
121MP0002019_abnormal_tumor_incidence0.65403988
122MP0005334_abnormal_fat_pad0.65336127
123MP0005165_increased_susceptibility_to0.64631334
124MP0003567_abnormal_fetal_cardiomyocyte0.61838307
125MP0001853_heart_inflammation0.61348453
126MP0000604_amyloidosis0.61089839
127MP0000358_abnormal_cell_content/0.57640259
128MP0001765_abnormal_ion_homeostasis0.56810863
129MP0003828_pulmonary_edema0.56596044
130MP0004145_abnormal_muscle_electrophysio0.56304810
131MP0005448_abnormal_energy_balance0.56197775
132MP0002970_abnormal_white_adipose0.55632372
133MP0002136_abnormal_kidney_physiology0.54804041
134MP0000013_abnormal_adipose_tissue0.54330904
135MP0003868_abnormal_feces_composition0.54117217
136MP0001529_abnormal_vocalization0.52736900
137MP0004185_abnormal_adipocyte_glucose0.52428131
138MP0003950_abnormal_plasma_membrane0.52342660
139MP0004233_abnormal_muscle_weight0.51310799
140MP0003953_abnormal_hormone_level0.48207864
141MP0004782_abnormal_surfactant_physiolog0.48094748
142MP0009764_decreased_sensitivity_to0.48079200

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.83545571
2Hepatic necrosis (HP:0002605)4.81396413
3Abnormal mitochondria in muscle tissue (HP:0008316)4.69887125
4Acute necrotizing encephalopathy (HP:0006965)4.69256809
5Acute encephalopathy (HP:0006846)4.66866520
6Cerebral edema (HP:0002181)4.39076275
7Abnormality of fatty-acid metabolism (HP:0004359)4.25823314
8Myoglobinuria (HP:0002913)4.17692906
9Hepatocellular necrosis (HP:0001404)4.15240950
10Abnormality of glycolysis (HP:0004366)4.15044004
11Increased serum pyruvate (HP:0003542)4.15044004
12Mitochondrial inheritance (HP:0001427)4.04890662
13Ketoacidosis (HP:0001993)3.97236691
14Increased CSF lactate (HP:0002490)3.94395661
15Hyperammonemia (HP:0001987)3.91302662
16Generalized aminoaciduria (HP:0002909)3.90652983
17Abnormality of dicarboxylic acid metabolism (HP:0010995)3.89970142
18Dicarboxylic aciduria (HP:0003215)3.89970142
19Progressive macrocephaly (HP:0004481)3.89130289
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.86583905
21Ketosis (HP:0001946)3.83724477
22Rhabdomyolysis (HP:0003201)3.72167081
23Exercise-induced muscle cramps (HP:0003710)3.67994153
24Hyperglycinuria (HP:0003108)3.62867054
25Increased muscle lipid content (HP:0009058)3.61473467
26Hypobetalipoproteinemia (HP:0003563)3.48505850
27Lactic acidosis (HP:0003128)3.47837316
28Lethargy (HP:0001254)3.33454091
29Intrahepatic cholestasis (HP:0001406)3.29499239
30Increased intramyocellular lipid droplets (HP:0012240)3.26783987
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26405061
32Abnormality of serine family amino acid metabolism (HP:0010894)3.24980173
33Abnormality of glycine metabolism (HP:0010895)3.24980173
34Lipid accumulation in hepatocytes (HP:0006561)3.21975579
35Exercise-induced myalgia (HP:0003738)3.14881489
36Proximal tubulopathy (HP:0000114)3.13356299
37Abnormality of urine glucose concentration (HP:0011016)3.07876855
38Glycosuria (HP:0003076)3.07876855
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07622796
40Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07622796
41Sudden death (HP:0001699)3.06897927
42Metabolic acidosis (HP:0001942)3.05758928
43Respiratory failure (HP:0002878)3.01604088
44Nausea (HP:0002018)2.99933014
45Xanthomatosis (HP:0000991)2.99287310
46Exercise intolerance (HP:0003546)2.94966683
47Increased serum lactate (HP:0002151)2.93651184
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.92978392
49Nemaline bodies (HP:0003798)2.90879845
50Type I transferrin isoform profile (HP:0003642)2.89498881
51Reduced antithrombin III activity (HP:0001976)2.86181720
52* Palpitations (HP:0001962)2.84356247
53Calf muscle hypertrophy (HP:0008981)2.82829414
54Methylmalonic acidemia (HP:0002912)2.82088827
55Vomiting (HP:0002013)2.78225428
56Ventricular tachycardia (HP:0004756)2.77985009
57Hyperglycinemia (HP:0002154)2.77862602
58Aplastic anemia (HP:0001915)2.73530033
59Ragged-red muscle fibers (HP:0003200)2.73225363
60Exertional dyspnea (HP:0002875)2.72803075
61Muscle fiber inclusion bodies (HP:0100299)2.71861773
62Increased hepatocellular lipid droplets (HP:0006565)2.71607456
63Hypolipoproteinemia (HP:0010981)2.71415309
64Deep venous thrombosis (HP:0002625)2.69446968
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.64803876
66Prolonged partial thromboplastin time (HP:0003645)2.64471376
67Muscle hypertrophy of the lower extremities (HP:0008968)2.62333579
683-Methylglutaconic aciduria (HP:0003535)2.60732175
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58899697
70Abnormality of glutamine family amino acid metabolism (HP:0010902)2.57417126
71Gout (HP:0001997)2.56035141
72Lipoatrophy (HP:0100578)2.53270434
73Abnormality of vitamin B metabolism (HP:0004340)2.52885175
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52414136
75Hyperbilirubinemia (HP:0002904)2.50381521
76CNS demyelination (HP:0007305)2.50140463
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42492336
78Abnormality of the vitamin B12 metabolism (HP:0004341)2.39523195
79Hyperlipoproteinemia (HP:0010980)2.36106892
80Dilated cardiomyopathy (HP:0001644)2.34920996
81Cholelithiasis (HP:0001081)2.34541210
82Abnormality of serum amino acid levels (HP:0003112)2.34087072
83Hyperinsulinemic hypoglycemia (HP:0000825)2.32831827
84Abnormal gallbladder morphology (HP:0012437)2.32750861
85Methylmalonic aciduria (HP:0012120)2.32558989
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31753546
87Abnormal protein N-linked glycosylation (HP:0012347)2.31753546
88Abnormal protein glycosylation (HP:0012346)2.31753546
89Abnormal glycosylation (HP:0012345)2.31753546
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28794266
91Pancreatic islet-cell hyperplasia (HP:0004510)2.27613402
92Hypoalphalipoproteinemia (HP:0003233)2.27322276
93Abnormality of purine metabolism (HP:0004352)2.26373152
94Cholecystitis (HP:0001082)2.26137079
95Abnormal gallbladder physiology (HP:0012438)2.26137079
96Renal cortical cysts (HP:0000803)2.25548708
97Congenital, generalized hypertrichosis (HP:0004540)2.24903878
98Megaloblastic anemia (HP:0001889)2.23264701
99Oral leukoplakia (HP:0002745)2.22451663
100Abnormality of methionine metabolism (HP:0010901)2.22047762
101Late onset (HP:0003584)2.20840275
102Respiratory difficulties (HP:0002880)2.19288830
103Neoplasm of head and neck (HP:0012288)2.19000477
104Esophageal neoplasm (HP:0100751)2.19000477
105Leukodystrophy (HP:0002415)2.18585671
106Muscle stiffness (HP:0003552)2.15437624
107Renal Fanconi syndrome (HP:0001994)2.15157240
108Abnormality of the intrinsic pathway (HP:0010989)2.14780394
109Pancytopenia (HP:0001876)2.14180697
110Hypoglycemic seizures (HP:0002173)2.13868591
111Right ventricular cardiomyopathy (HP:0011663)2.13026154
112Multiple enchondromatosis (HP:0005701)2.12123845
113Abnormality of nucleobase metabolism (HP:0010932)2.11708283
114Fat malabsorption (HP:0002630)2.10445632
115Abnormality of the anterior horn cell (HP:0006802)2.04770765
116Degeneration of anterior horn cells (HP:0002398)2.04770765
117Abnormality of sulfur amino acid metabolism (HP:0004339)2.04463166
118Hyperphosphaturia (HP:0003109)2.03540864
119Increased purine levels (HP:0004368)2.03274887
120Hyperuricemia (HP:0002149)2.03274887
121Abnormality of alanine metabolism (HP:0010916)2.00172030
122Hyperalaninemia (HP:0003348)2.00172030
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00172030
124Optic disc pallor (HP:0000543)1.99490121
125Symptomatic seizures (HP:0011145)1.98606552
126Posterior subcapsular cataract (HP:0007787)1.93021167
127Vacuolated lymphocytes (HP:0001922)1.91361218
128Microvesicular hepatic steatosis (HP:0001414)1.90723306
129Paralysis (HP:0003470)1.90279628
130Abnormality of renal resorption (HP:0011038)1.90054258
131Amniotic constriction ring (HP:0009775)1.87673148
132Abnormality of placental membranes (HP:0011409)1.87673148
133Abnormality of vitamin metabolism (HP:0100508)1.87134043
134Macrocytic anemia (HP:0001972)1.81349540
135Steatorrhea (HP:0002570)1.81309093
136Abnormality of the labia minora (HP:0012880)1.74223486
137Abnormal pupillary function (HP:0007686)1.70512228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.62100063
2OBSCN4.36954658
3VRK24.04291145
4MYLK3.86580098
5PDK33.37536130
6PDK43.37536130
7NEK13.13121079
8EIF2AK12.59877598
9PKN22.56215640
10TTN2.28217538
11LMTK22.20513183
12FLT31.99054213
13PDK21.98707641
14NUAK11.98372638
15PIK3CA1.86729262
16NME11.86493989
17SRPK11.86162471
18PLK31.83984001
19TTK1.82304967
20NME21.81113271
21WNK41.81033447
22STK241.78831000
23TRIM281.66840361
24STK161.59635032
25TRIB31.51596943
26PIK3CG1.50841003
27MAP3K31.48631908
28STK38L1.46274392
29MKNK21.41883719
30PBK1.41745133
31INSRR1.41684780
32PLK41.41619053
33PHKG21.37956033
34PHKG11.37956033
35MAP2K31.32293890
36ABL21.32255431
37MKNK11.32088658
38BMPR1B1.31269359
39CDC71.30305278
40ERBB31.24930463
41KDR1.24910736
42EIF2AK31.22019729
43NEK91.18081064
44MST1R1.15477251
45MST41.13172497
46ZAK1.12986528
47FRK1.12269451
48TAF11.09661616
49EIF2AK21.08373692
50LIMK11.07990158
51ERN11.05978332
52PINK11.05833331
53MUSK1.04390429
54WNK31.04066568
55ILK1.01705301
56GRK11.01043805
57BUB11.00643868
58ACVR1B0.94366201
59TESK10.93040567
60TNIK0.92132657
61PLK10.90189850
62MAP3K120.89538381
63TIE10.87603204
64MAP3K110.86560275
65ERBB40.82572111
66SIK10.82329982
67ARAF0.79098233
68DAPK10.78506621
69STK40.76838218
70ADRBK20.75236361
71SCYL20.74980167
72MAP4K20.74226930
73STK100.72178921
74STK30.70822785
75MAPKAPK50.70081245
76TXK0.69836786
77PIM20.69124990
78TYK20.68829546
79MAPK110.66943969
80MAP2K60.66933831
81PRKG20.65615430
82TRPM70.64925704
83MAPKAPK30.64016214
84GRK70.63829269
85OXSR10.62350753
86PASK0.61795939
87VRK10.61366309
88BRSK20.61184315
89DAPK30.60491930
90MAPK120.60209138
91MAP3K50.60050482
92MAP2K40.59744184
93CSNK1G30.59122292
94CSNK1G10.58483537
95TEC0.55837340
96FGFR40.54804559
97LRRK20.54289274
98NLK0.53636647
99PRKAA20.53519044
100CCNB10.51919092
101STK390.51012384
102WEE10.50006057
103CAMK2D0.49230671
104PRKACG0.49198374
105TBK10.47750050
106CAMK2G0.47672629
107PRKAA10.47326298
108CSNK2A20.46969306
109BRSK10.46077008
110TESK20.45196750
111IRAK30.43851213
112ALK0.42512041
113PLK20.40784626
114BMPR20.40465435
115BCR0.39410178
116MAP2K10.38838355
117CSNK2A10.37439606
118CSNK1G20.36697352
119ATR0.35311685
120PRKACA0.35219076
121PAK30.35043460
122CSNK1A1L0.34232080
123TSSK60.34132673
124GRK60.33739549
125TGFBR10.33557174
126RPS6KC10.32535720
127RPS6KL10.32535720
128MAPK40.31702292
129RPS6KB20.30696903
130RPS6KA60.29836452
131JAK20.29796503
132CLK10.29367931
133SIK30.29233844
134AURKB0.28867363
135PRKACB0.28741351
136MET0.28465530
137CHEK20.27393827
138MAP3K80.26064182
139FER0.25544332
140PAK40.25289149
141PRKCI0.24965164
142CDK80.24961035
143PTK60.24944356
144PRKCD0.24880240
145TAOK30.24140443
146TLK10.23382434

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.14858279
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.35299890
3Propanoate metabolism_Homo sapiens_hsa006403.15476296
4Fatty acid degradation_Homo sapiens_hsa000712.94050569
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.93144047
6* Oxidative phosphorylation_Homo sapiens_hsa001902.86656485
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.84762687
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78961377
9Parkinsons disease_Homo sapiens_hsa050122.62364881
10Pyruvate metabolism_Homo sapiens_hsa006202.41655384
11* Carbon metabolism_Homo sapiens_hsa012002.33080514
12Fatty acid metabolism_Homo sapiens_hsa012122.24556216
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.19686355
14Butanoate metabolism_Homo sapiens_hsa006502.12767349
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10298622
16Tryptophan metabolism_Homo sapiens_hsa003802.07755953
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98751007
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98136927
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.93903806
20Fatty acid elongation_Homo sapiens_hsa000621.89967113
21Peroxisome_Homo sapiens_hsa041461.86341136
22Sulfur metabolism_Homo sapiens_hsa009201.85223237
23* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80470420
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75031125
25Alzheimers disease_Homo sapiens_hsa050101.74528906
26Arginine biosynthesis_Homo sapiens_hsa002201.74000380
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70250394
28Biosynthesis of amino acids_Homo sapiens_hsa012301.65857454
29Homologous recombination_Homo sapiens_hsa034401.63653978
30Huntingtons disease_Homo sapiens_hsa050161.61131551
31beta-Alanine metabolism_Homo sapiens_hsa004101.56812958
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54280628
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53877174
34PPAR signaling pathway_Homo sapiens_hsa033201.49412464
35Cardiac muscle contraction_Homo sapiens_hsa042601.49229791
36Phenylalanine metabolism_Homo sapiens_hsa003601.44385003
37Proteasome_Homo sapiens_hsa030501.43458051
38Non-homologous end-joining_Homo sapiens_hsa034501.43182974
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.32587714
40Starch and sucrose metabolism_Homo sapiens_hsa005001.29102445
41Nucleotide excision repair_Homo sapiens_hsa034201.27895184
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27536389
43Histidine metabolism_Homo sapiens_hsa003401.21359685
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20553102
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.19017189
46Nitrogen metabolism_Homo sapiens_hsa009101.17857182
47Tyrosine metabolism_Homo sapiens_hsa003501.16005737
48Basal transcription factors_Homo sapiens_hsa030221.13780206
49Folate biosynthesis_Homo sapiens_hsa007901.10006533
50RNA degradation_Homo sapiens_hsa030181.08589393
51Selenocompound metabolism_Homo sapiens_hsa004501.05010897
52Base excision repair_Homo sapiens_hsa034101.04614667
53Complement and coagulation cascades_Homo sapiens_hsa046101.04571787
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04101347
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03226544
56Glutathione metabolism_Homo sapiens_hsa004801.02440678
57Chemical carcinogenesis_Homo sapiens_hsa052041.01425691
58Arginine and proline metabolism_Homo sapiens_hsa003301.00849771
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97413188
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96151838
61RNA transport_Homo sapiens_hsa030130.95269861
62Pentose phosphate pathway_Homo sapiens_hsa000300.94451108
63Fat digestion and absorption_Homo sapiens_hsa049750.94444108
64Spliceosome_Homo sapiens_hsa030400.91334960
65Protein export_Homo sapiens_hsa030600.90991346
66Galactose metabolism_Homo sapiens_hsa000520.86873558
67Fructose and mannose metabolism_Homo sapiens_hsa000510.84880152
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84069389
69* Metabolic pathways_Homo sapiens_hsa011000.82139303
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.81826177
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79321301
72Fanconi anemia pathway_Homo sapiens_hsa034600.76372190
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.72431125
74Caffeine metabolism_Homo sapiens_hsa002320.72254865
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70401466
76Retinol metabolism_Homo sapiens_hsa008300.69246321
77Bile secretion_Homo sapiens_hsa049760.64629168
78One carbon pool by folate_Homo sapiens_hsa006700.62924850
79Sulfur relay system_Homo sapiens_hsa041220.61775993
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.61328751
81Steroid biosynthesis_Homo sapiens_hsa001000.60317689
82Ribosome_Homo sapiens_hsa030100.58493572
83Mineral absorption_Homo sapiens_hsa049780.57270745
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56601031
85Asthma_Homo sapiens_hsa053100.52820612
86Linoleic acid metabolism_Homo sapiens_hsa005910.50454860
87Glycerolipid metabolism_Homo sapiens_hsa005610.49354407
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45497573
89Pyrimidine metabolism_Homo sapiens_hsa002400.45339763
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43631800
91Staphylococcus aureus infection_Homo sapiens_hsa051500.43004746
92ABC transporters_Homo sapiens_hsa020100.42560466
93Vitamin digestion and absorption_Homo sapiens_hsa049770.40808601
94Type I diabetes mellitus_Homo sapiens_hsa049400.40785895
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39638643
96Cell cycle_Homo sapiens_hsa041100.38201857
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37881896
98Fatty acid biosynthesis_Homo sapiens_hsa000610.36626544
99N-Glycan biosynthesis_Homo sapiens_hsa005100.33952698
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32875736
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31807392
102Antigen processing and presentation_Homo sapiens_hsa046120.30429116
103Lysine degradation_Homo sapiens_hsa003100.29910024
104Glucagon signaling pathway_Homo sapiens_hsa049220.26006397
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.21050404
106RNA polymerase_Homo sapiens_hsa030200.20944051
107Dilated cardiomyopathy_Homo sapiens_hsa054140.20345537
108Insulin resistance_Homo sapiens_hsa049310.19458545
109DNA replication_Homo sapiens_hsa030300.18706663
110Purine metabolism_Homo sapiens_hsa002300.17265341
111Vitamin B6 metabolism_Homo sapiens_hsa007500.15644885
112Collecting duct acid secretion_Homo sapiens_hsa049660.12832337
113Renin-angiotensin system_Homo sapiens_hsa046140.12667774
114Legionellosis_Homo sapiens_hsa051340.12317869
115Arachidonic acid metabolism_Homo sapiens_hsa005900.07072148
116AMPK signaling pathway_Homo sapiens_hsa041520.06829472
117Vibrio cholerae infection_Homo sapiens_hsa051100.05779302
118Mismatch repair_Homo sapiens_hsa034300.04966265
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01344830
120Insulin signaling pathway_Homo sapiens_hsa049100.00759121

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