SDHDP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)9.55251147
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.45751509
3cytidine deamination (GO:0009972)7.04987703
4cytidine metabolic process (GO:0046087)7.04987703
5cytidine catabolic process (GO:0006216)7.04987703
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.08437577
7rRNA methylation (GO:0031167)5.97646707
8rRNA modification (GO:0000154)5.82168286
9protein deneddylation (GO:0000338)4.93890774
10cullin deneddylation (GO:0010388)4.87080962
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.16470019
12DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.15405214
13intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.05284890
14signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.05284890
15signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.02483978
16signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.02483978
17signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.02483978
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.98813789
19preassembly of GPI anchor in ER membrane (GO:0016254)3.97009494
20deoxyribose phosphate biosynthetic process (GO:0046385)3.96907932
212-deoxyribonucleotide biosynthetic process (GO:0009265)3.96907932
22regulation of cellular amino acid metabolic process (GO:0006521)3.96748843
23cellular response to interleukin-15 (GO:0071350)3.95883384
24regulation of translational termination (GO:0006449)3.91405204
25mitochondrion distribution (GO:0048311)3.90712475
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.86913989
27proteasome assembly (GO:0043248)3.84980242
28signal transduction involved in DNA integrity checkpoint (GO:0072401)3.81395997
29signal transduction involved in DNA damage checkpoint (GO:0072422)3.81395997
30positive regulation of defense response to virus by host (GO:0002230)3.78550490
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.77560025
32signal transduction involved in cell cycle checkpoint (GO:0072395)3.73208059
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68301492
34negative regulation of ligase activity (GO:0051352)3.68301492
35deoxyribonucleotide biosynthetic process (GO:0009263)3.67340881
36positive regulation of prostaglandin secretion (GO:0032308)3.57365830
37negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.52370214
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45460547
39signal peptide processing (GO:0006465)3.44670975
40organelle disassembly (GO:1903008)3.29470677
41positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29265827
42ribonucleoprotein complex disassembly (GO:0032988)3.25325480
43response to interleukin-15 (GO:0070672)3.24976530
44regulation of prostaglandin secretion (GO:0032306)3.22437782
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19387343
46protein K6-linked ubiquitination (GO:0085020)3.19147209
47positive regulation of cell cycle arrest (GO:0071158)3.16867360
48positive regulation of ligase activity (GO:0051351)3.14932820
49regulation of interleukin-8 secretion (GO:2000482)3.14926747
50termination of RNA polymerase III transcription (GO:0006386)3.10903019
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.10903019
52DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.10465333
53peptidyl-histidine modification (GO:0018202)3.09620926
54cytochrome complex assembly (GO:0017004)3.04899270
55DNA catabolic process, exonucleolytic (GO:0000738)3.00570018
56T cell apoptotic process (GO:0070231)2.99416091
57negative regulation of execution phase of apoptosis (GO:1900118)2.98845360
58antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98683320
59protein heterotetramerization (GO:0051290)2.97841739
60ATP synthesis coupled proton transport (GO:0015986)2.97042221
61energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97042221
62regulation of mitochondrial translation (GO:0070129)2.95558487
63ER overload response (GO:0006983)2.94415640
64respiratory chain complex IV assembly (GO:0008535)2.91853930
65DNA demethylation (GO:0080111)2.91033682
66regulation of defense response to virus by host (GO:0050691)2.89598457
67negative regulation of B cell apoptotic process (GO:0002903)2.89093349
68ribosomal small subunit assembly (GO:0000028)2.85710589
69deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.85519517
70eosinophil chemotaxis (GO:0048245)2.81713991
71regulation of isotype switching to IgG isotypes (GO:0048302)2.81060324
72regulation of ubiquitin-protein transferase activity (GO:0051438)2.79252796
73lymphocyte apoptotic process (GO:0070227)2.75190506
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75061210
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75004230
76AMP metabolic process (GO:0046033)2.74327943
77DNA double-strand break processing (GO:0000729)2.73968542
78negative regulation of calcium ion transport into cytosol (GO:0010523)2.72250476
79negative regulation of macroautophagy (GO:0016242)2.71796164
80regulation of ligase activity (GO:0051340)2.69400100
81regulation of cellular amine metabolic process (GO:0033238)2.68607194
82T cell migration (GO:0072678)2.66822212
83regulation of interleukin-2 biosynthetic process (GO:0045076)2.65834912
84pyrimidine nucleoside catabolic process (GO:0046135)2.64072893
85negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.63324791
86negative regulation of cell cycle G1/S phase transition (GO:1902807)2.63324791
87mismatch repair (GO:0006298)2.63207226
88pyrimidine ribonucleoside metabolic process (GO:0046131)2.62990018
89pseudouridine synthesis (GO:0001522)2.61085581
90amino acid activation (GO:0043038)2.59012917
91tRNA aminoacylation (GO:0043039)2.59012917
92chaperone-mediated protein transport (GO:0072321)2.57440821
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56616357
94protein complex biogenesis (GO:0070271)2.56159190
95regulation of T cell receptor signaling pathway (GO:0050856)2.55558005
96pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.55354014
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.55216214
98regulation of vacuole organization (GO:0044088)2.55047892
99water-soluble vitamin biosynthetic process (GO:0042364)2.52228769
100respiratory electron transport chain (GO:0022904)2.50634481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.70586163
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.74155736
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.64777562
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.43201614
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.87924940
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.65663000
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.41151867
8VDR_22108803_ChIP-Seq_LS180_Human3.14448595
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83965318
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73980256
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69676045
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.68727373
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61057815
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55871346
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.53119576
16VDR_23849224_ChIP-Seq_CD4+_Human2.50964852
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39161301
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29802227
19ELK1_19687146_ChIP-ChIP_HELA_Human2.27199297
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19106963
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.16628887
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14759699
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.06476500
24FOXP3_21729870_ChIP-Seq_TREG_Human2.00040662
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.97645705
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93977031
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87228432
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86184004
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83467711
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79676043
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78873046
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75178346
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69937735
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67618913
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.67534859
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.57059734
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54975452
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48144876
39DCP1A_22483619_ChIP-Seq_HELA_Human1.46555983
40GATA3_26560356_Chip-Seq_TH2_Human1.45490882
41PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.42296469
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39340768
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38944434
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33172477
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30713244
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30124019
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.29466347
48MYB_26560356_Chip-Seq_TH2_Human1.27975654
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.22921101
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21415377
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19977821
52SOX2_19829295_ChIP-Seq_ESCs_Human1.17733268
53NANOG_19829295_ChIP-Seq_ESCs_Human1.17733268
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13492310
55MYC_18940864_ChIP-ChIP_HL60_Human1.11096386
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10742444
57EWS_26573619_Chip-Seq_HEK293_Human1.08065770
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07062730
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06199437
60AR_20517297_ChIP-Seq_VCAP_Human1.05522530
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05399309
62RUNX_20019798_ChIP-Seq_JUKART_Human1.03800061
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02800621
64IGF1R_20145208_ChIP-Seq_DFB_Human0.99834384
65MYB_26560356_Chip-Seq_TH1_Human0.99362204
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98850802
67IRF1_19129219_ChIP-ChIP_H3396_Human0.98247713
68GABP_19822575_ChIP-Seq_HepG2_Human0.95096299
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94113470
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93910115
71P300_19829295_ChIP-Seq_ESCs_Human0.93026006
72EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92074403
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89722322
74ZNF274_21170338_ChIP-Seq_K562_Hela0.89469145
75POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89257486
76KDM5A_27292631_Chip-Seq_BREAST_Human0.88660590
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88656740
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87879564
79TP53_22573176_ChIP-Seq_HFKS_Human0.87721528
80ELK1_22589737_ChIP-Seq_MCF10A_Human0.87487543
81SPI1_23547873_ChIP-Seq_NB4_Human0.87414469
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84340022
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83924667
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.83924667
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83634538
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83421599
87SALL4_22934838_ChIP-ChIP_CD34+_Human0.83363155
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.83030113
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82893459
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82122614
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80901607
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78504690
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.76701575
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76635648
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.76559891
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.76546620
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76333809
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.75841944
99NELFA_20434984_ChIP-Seq_ESCs_Mouse0.74511984
100ER_23166858_ChIP-Seq_MCF-7_Human0.74401786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009333_abnormal_splenocyte_physiolog3.92141195
2MP0002138_abnormal_hepatobiliary_system3.64932849
3MP0002102_abnormal_ear_morphology3.43717566
4MP0003806_abnormal_nucleotide_metabolis3.39404053
5MP0005671_abnormal_response_to3.36966226
6MP0000685_abnormal_immune_system2.78422060
7MP0003045_fibrosis2.73618777
8MP0005083_abnormal_biliary_tract2.67498707
9MP0002166_altered_tumor_susceptibility2.63199399
10MP0002876_abnormal_thyroid_physiology2.60207659
11MP0009785_altered_susceptibility_to2.58236676
12MP0002148_abnormal_hypersensitivity_rea2.56299108
13MP0002006_tumorigenesis2.52949037
14MP0001835_abnormal_antigen_presentation2.48614688
15MP0004957_abnormal_blastocyst_morpholog2.17678979
16MP0004145_abnormal_muscle_electrophysio2.15562699
17MP0003786_premature_aging2.13283687
18MP0005408_hypopigmentation2.11970485
19MP0010386_abnormal_urinary_bladder2.11949085
20MP0005360_urolithiasis2.05724272
21MP0005000_abnormal_immune_tolerance2.02145322
22MP0000747_muscle_weakness1.97420278
23MP0001800_abnormal_humoral_immune1.95090796
24MP0006035_abnormal_mitochondrial_morpho1.94068837
25MP0001790_abnormal_immune_system1.90525481
26MP0005387_immune_system_phenotype1.90525481
27MP0006036_abnormal_mitochondrial_physio1.89246500
28MP0008058_abnormal_DNA_repair1.78166924
29MP0003866_abnormal_defecation1.73329138
30MP0010094_abnormal_chromosome_stability1.73115753
31MP0002723_abnormal_immune_serum1.63539621
32MP0002277_abnormal_respiratory_mucosa1.62277557
33MP0002420_abnormal_adaptive_immunity1.58778435
34MP0001819_abnormal_immune_cell1.53805214
35MP0005165_increased_susceptibility_to1.48053998
36MP0006082_CNS_inflammation1.47757800
37MP0003252_abnormal_bile_duct1.43061105
38MP0003693_abnormal_embryo_hatching1.41727917
39MP0008057_abnormal_DNA_replication1.40470995
40MP0005025_abnormal_response_to1.40158428
41MP0002452_abnormal_antigen_presenting1.37737169
42MP0002163_abnormal_gland_morphology1.34229867
43MP0001873_stomach_inflammation1.33245290
44MP0002398_abnormal_bone_marrow1.30346444
45MP0000751_myopathy1.30297436
46MP0008877_abnormal_DNA_methylation1.27581364
47MP0000703_abnormal_thymus_morphology1.26702619
48MP0003195_calcinosis1.26338136
49MP0000716_abnormal_immune_system1.24958424
50MP0004134_abnormal_chest_morphology1.22015944
51MP0002095_abnormal_skin_pigmentation1.20969718
52MP0003646_muscle_fatigue1.18288066
53MP0008007_abnormal_cellular_replicative1.16968615
54MP0002396_abnormal_hematopoietic_system1.13452535
55MP0002722_abnormal_immune_system1.12142521
56MP0003763_abnormal_thymus_physiology1.11382580
57MP0003077_abnormal_cell_cycle1.11049820
58MP0000689_abnormal_spleen_morphology1.08328363
59MP0003283_abnormal_digestive_organ1.08211189
60MP0000372_irregular_coat_pigmentation1.03770773
61MP0001845_abnormal_inflammatory_respons1.03212811
62MP0002429_abnormal_blood_cell1.03114018
63MP0001348_abnormal_lacrimal_gland1.01842176
64MP0004885_abnormal_endolymph1.00940936
65MP0005379_endocrine/exocrine_gland_phen0.99337897
66MP0005085_abnormal_gallbladder_physiolo0.97471299
67MP0000749_muscle_degeneration0.97374990
68MP0003111_abnormal_nucleus_morphology0.95508892
69MP0002419_abnormal_innate_immunity0.94528912
70MP0003448_altered_tumor_morphology0.92900627
71MP0005410_abnormal_fertilization0.92885501
72MP0002693_abnormal_pancreas_physiology0.92145063
73MP0001661_extended_life_span0.92130120
74MP0006072_abnormal_retinal_apoptosis0.89484774
75MP0003718_maternal_effect0.89337339
76MP0002736_abnormal_nociception_after0.88202168
77MP0001968_abnormal_touch/_nociception0.87865992
78MP0001905_abnormal_dopamine_level0.84563267
79MP0008872_abnormal_physiological_respon0.79895976
80MP0005365_abnormal_bile_salt0.79205231
81MP0004510_myositis0.78426779
82MP0010155_abnormal_intestine_physiology0.78125091
83MP0004147_increased_porphyrin_level0.77513987
84MP0001765_abnormal_ion_homeostasis0.76769187
85MP0000358_abnormal_cell_content/0.76453884
86MP0002405_respiratory_system_inflammati0.74205601
87MP0001756_abnormal_urination0.74130402
88MP0000681_abnormal_thyroid_gland0.73708156
89MP0002269_muscular_atrophy0.70978436
90MP0000569_abnormal_digit_pigmentation0.70744113
91MP0003950_abnormal_plasma_membrane0.70540375
92MP0002019_abnormal_tumor_incidence0.69669952
93MP0005464_abnormal_platelet_physiology0.68744968
94MP0004947_skin_inflammation0.68494294
95MP0005310_abnormal_salivary_gland0.67647228
96MP0004036_abnormal_muscle_relaxation0.67408452
97MP0009765_abnormal_xenobiotic_induced0.67313762
98MP0005395_other_phenotype0.64672890
99MP0001853_heart_inflammation0.64563653
100MP0005084_abnormal_gallbladder_morpholo0.64169757

Predicted human phenotypes

RankGene SetZ-score
1Neonatal respiratory distress (HP:0002643)4.64580384
2Febrile seizures (HP:0002373)4.42661311
3Colon cancer (HP:0003003)4.41827008
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.25641107
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.25641107
6Optic neuritis (HP:0100653)3.89243182
7Retrobulbar optic neuritis (HP:0100654)3.89243182
8Hepatosplenomegaly (HP:0001433)3.83483309
9Acute necrotizing encephalopathy (HP:0006965)3.80028847
10Orchitis (HP:0100796)3.70474219
11Myositis (HP:0100614)3.60140140
12Hypokinesia (HP:0002375)3.59976406
13Abnormal mitochondria in muscle tissue (HP:0008316)3.41364740
14Increased CSF lactate (HP:0002490)3.41197081
15Hepatic necrosis (HP:0002605)3.39770427
16Mitochondrial inheritance (HP:0001427)3.37609441
17Keratoconjunctivitis sicca (HP:0001097)3.30104679
18Hepatocellular necrosis (HP:0001404)3.29094501
19Conjunctival hamartoma (HP:0100780)3.26463787
20Acute encephalopathy (HP:0006846)3.24962658
21Progressive macrocephaly (HP:0004481)3.22751797
22Keratoconjunctivitis (HP:0001096)3.13339777
23Aplastic anemia (HP:0001915)3.02034273
24Cerebral edema (HP:0002181)2.95887633
25Metaphyseal dysplasia (HP:0100255)2.92543187
26Abnormality of T cell number (HP:0011839)2.84367106
27Palpitations (HP:0001962)2.83687178
28Joint swelling (HP:0001386)2.72060800
29IgA deficiency (HP:0002720)2.69579259
30Neoplasm of the adrenal gland (HP:0100631)2.69100678
31Increased serum lactate (HP:0002151)2.68733967
32Premature loss of primary teeth (HP:0006323)2.64303424
33Cerebral hemorrhage (HP:0001342)2.56074217
34Chronic diarrhea (HP:0002028)2.50632314
35Generalized aminoaciduria (HP:0002909)2.47205015
36Neuroendocrine neoplasm (HP:0100634)2.47012818
37T lymphocytopenia (HP:0005403)2.46853300
38Cavernous hemangioma (HP:0001048)2.45168671
39Prostate neoplasm (HP:0100787)2.42834628
40Elevated erythrocyte sedimentation rate (HP:0003565)2.42248514
41Tubulointerstitial fibrosis (HP:0005576)2.36364912
42Lactic acidosis (HP:0003128)2.36282843
43Increased density of long bones (HP:0006392)2.30453937
44IgM deficiency (HP:0002850)2.30100888
45Oral leukoplakia (HP:0002745)2.29305740
46Abnormal spermatogenesis (HP:0008669)2.25576250
47Respiratory failure (HP:0002878)2.24242256
48Conjugated hyperbilirubinemia (HP:0002908)2.24152062
49Pheochromocytoma (HP:0002666)2.23172693
50Neck muscle weakness (HP:0000467)2.22641634
51Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21975663
52Exercise intolerance (HP:0003546)2.21721926
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.20975819
54Melanoma (HP:0002861)2.20873443
55Abnormality of the prostate (HP:0008775)2.20059593
56Congenital ichthyosiform erythroderma (HP:0007431)2.17615384
57Lipid accumulation in hepatocytes (HP:0006561)2.14268158
58Abnormality of the renal cortex (HP:0011035)2.13436629
59Optic disc pallor (HP:0000543)2.09804395
60Autoimmune hemolytic anemia (HP:0001890)2.07927355
61Diminished movement (HP:0002374)2.07112829
62Abnormality of T cells (HP:0002843)2.04964609
63Abnormality of the labia minora (HP:0012880)2.02708103
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.01614671
65Renal cortical cysts (HP:0000803)1.99731031
66Hamartoma of the eye (HP:0010568)1.92921182
67Keratitis (HP:0000491)1.92432603
68Vacuolated lymphocytes (HP:0001922)1.92064037
69Facial diplegia (HP:0001349)1.89543665
70IgG deficiency (HP:0004315)1.87362869
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86063190
72Arterial thrombosis (HP:0004420)1.83897761
73Gangrene (HP:0100758)1.83607141
74Dyschromatopsia (HP:0007641)1.83140958
75Poor speech (HP:0002465)1.81012270
76Lethargy (HP:0001254)1.79227234
77Abnormality of methionine metabolism (HP:0010901)1.78095504
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77062718
79Hypoglycemic coma (HP:0001325)1.76640745
80Pulmonary infiltrates (HP:0002113)1.74294653
81Anorexia (HP:0002039)1.74291002
82Pancytopenia (HP:0001876)1.72959276
83Progressive microcephaly (HP:0000253)1.71119251
84Generalized tonic-clonic seizures (HP:0002069)1.71018822
85Increased hepatocellular lipid droplets (HP:0006565)1.70465884
86Abnormality of the anterior horn cell (HP:0006802)1.69992142
87Degeneration of anterior horn cells (HP:0002398)1.69992142
88Spinal cord lesions (HP:0100561)1.69907196
89Syringomyelia (HP:0003396)1.69907196
90Abnormality of dental color (HP:0011073)1.69196233
91Tetraparesis (HP:0002273)1.68900019
92Neoplasm of the peripheral nervous system (HP:0100007)1.68842028
93Uterine neoplasm (HP:0010784)1.68567507
94Abnormality of the vocal cords (HP:0008777)1.67282773
95Periodontitis (HP:0000704)1.66785948
96Clubbing of toes (HP:0100760)1.65745809
97Vasculitis (HP:0002633)1.65590090
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64977279
99Goiter (HP:0000853)1.64714546
100Methylmalonic aciduria (HP:0012120)1.64270376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.19641672
2TAF13.88425849
3MST43.33167868
4SMG13.22019280
5BCKDK2.96902735
6EIF2AK12.85477745
7STK162.83405347
8MAP2K62.82680817
9NUAK12.66736431
10EIF2AK32.64424755
11PDK22.62633364
12VRK12.49345251
13PIK3CA1.98169186
14BMPR21.88761459
15FRK1.85545338
16DAPK11.73173120
17SRPK11.64798826
18BUB11.61185798
19NME21.58567842
20ITK1.47273424
21TXK1.43393641
22PLK31.41361797
23NEK11.32370811
24BCR1.26982602
25EPHA41.21644905
26IKBKB1.20529195
27MAPKAPK51.17183670
28EIF2AK21.14713026
29GRK51.14521739
30STK391.12285759
31MELK1.02838667
32CSNK1G31.01700584
33ADRBK20.94097891
34KDR0.92832735
35PHKG10.92056389
36PHKG20.92056389
37WEE10.91156890
38LMTK20.90291763
39CSNK1A1L0.88631505
40PBK0.88103193
41CSNK1G20.87276209
42PLK40.86981276
43PRKCQ0.84719212
44INSRR0.84698770
45OXSR10.82010169
46CDK90.79966538
47MAP3K140.79586651
48CSNK1G10.79403406
49STK40.79108939
50DYRK20.78278869
51PINK10.78240823
52TLK10.75310055
53GRK10.73481384
54TRIM280.73288452
55MKNK20.69772517
56FGFR10.69222303
57TESK20.66383466
58TGFBR20.63780794
59ZAK0.63176820
60PLK20.62599637
61DAPK30.62451661
62CDK70.58702269
63TEC0.57389504
64BMPR1B0.54040760
65SYK0.50674407
66NEK60.47788567
67CDC70.46106438
68AURKB0.41910776
69PIK3CG0.40950095
70TBK10.40392300
71MAPKAPK20.39574177
72NEK90.39075519
73CAMK2G0.38141431
74MAP4K10.38071951
75ATR0.37874127
76MYLK0.37771996
77LCK0.35288499
78DAPK20.35236881
79ADRBK10.34264445
80BTK0.32880745
81CLK10.32627183
82CAMK2A0.31996286
83IKBKE0.31783648
84PLK10.31280025
85CHEK20.31248042
86LYN0.29493064
87CSNK2A10.29009761
88ARAF0.28799265
89TIE10.26653796
90TSSK60.26028221
91CSNK2A20.25436968
92TTK0.24798039
93JAK10.24558611
94CAMK2D0.24362567
95ACVR1B0.21465049
96GSK3A0.21045468
97PAK60.20104011
98HIPK20.19680989
99CHEK10.19422839
100MAPKAPK30.19342635

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.70796697
2Protein export_Homo sapiens_hsa030602.76164597
3RNA polymerase_Homo sapiens_hsa030202.59320600
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46570226
5Oxidative phosphorylation_Homo sapiens_hsa001902.46198129
6Graft-versus-host disease_Homo sapiens_hsa053322.44354251
7Homologous recombination_Homo sapiens_hsa034402.35862612
8Allograft rejection_Homo sapiens_hsa053302.15257596
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10517245
10Parkinsons disease_Homo sapiens_hsa050122.09744952
11Autoimmune thyroid disease_Homo sapiens_hsa053202.08561466
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05026637
13DNA replication_Homo sapiens_hsa030302.00835931
14Mismatch repair_Homo sapiens_hsa034301.96469526
15Rheumatoid arthritis_Homo sapiens_hsa053231.96345106
16Primary immunodeficiency_Homo sapiens_hsa053401.84860189
17Basal transcription factors_Homo sapiens_hsa030221.82147348
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81905837
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77906799
20One carbon pool by folate_Homo sapiens_hsa006701.76413690
21Type I diabetes mellitus_Homo sapiens_hsa049401.71358151
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71069306
23Pyrimidine metabolism_Homo sapiens_hsa002401.70287956
24Base excision repair_Homo sapiens_hsa034101.56410139
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.55157529
26Antigen processing and presentation_Homo sapiens_hsa046121.53935106
27Ribosome_Homo sapiens_hsa030101.51028908
28Huntingtons disease_Homo sapiens_hsa050161.50478155
29Fatty acid biosynthesis_Homo sapiens_hsa000611.49566221
30Asthma_Homo sapiens_hsa053101.42808712
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32380275
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30349830
33Spliceosome_Homo sapiens_hsa030401.27034245
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.23286883
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22007153
36Nucleotide excision repair_Homo sapiens_hsa034201.20394572
37Folate biosynthesis_Homo sapiens_hsa007901.20223750
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19911967
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.18597412
40RNA degradation_Homo sapiens_hsa030181.17675101
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16444196
42Fanconi anemia pathway_Homo sapiens_hsa034601.15744096
43Nitrogen metabolism_Homo sapiens_hsa009101.11463878
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08340084
45Alzheimers disease_Homo sapiens_hsa050101.07728915
46Purine metabolism_Homo sapiens_hsa002301.05667614
47Propanoate metabolism_Homo sapiens_hsa006401.02341486
48N-Glycan biosynthesis_Homo sapiens_hsa005100.97591735
49Hematopoietic cell lineage_Homo sapiens_hsa046400.96982831
50RNA transport_Homo sapiens_hsa030130.94487857
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92736437
52Epstein-Barr virus infection_Homo sapiens_hsa051690.92492196
53Collecting duct acid secretion_Homo sapiens_hsa049660.89581087
54Non-homologous end-joining_Homo sapiens_hsa034500.86341682
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.84267049
56Peroxisome_Homo sapiens_hsa041460.80417089
57Mineral absorption_Homo sapiens_hsa049780.79855454
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74170101
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.74086658
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71731297
61p53 signaling pathway_Homo sapiens_hsa041150.69155171
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68496660
63Measles_Homo sapiens_hsa051620.66065441
64Vitamin B6 metabolism_Homo sapiens_hsa007500.64905203
65Pyruvate metabolism_Homo sapiens_hsa006200.64300194
66Phototransduction_Homo sapiens_hsa047440.62964493
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62661816
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62553783
69Metabolic pathways_Homo sapiens_hsa011000.61197919
70Fatty acid elongation_Homo sapiens_hsa000620.57998512
71Glutathione metabolism_Homo sapiens_hsa004800.55823124
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50461884
73Systemic lupus erythematosus_Homo sapiens_hsa053220.50381506
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49559313
75Cardiac muscle contraction_Homo sapiens_hsa042600.47619333
76Retinol metabolism_Homo sapiens_hsa008300.45189811
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45048515
78Regulation of autophagy_Homo sapiens_hsa041400.44835275
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.44613321
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44308662
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42829820
82Herpes simplex infection_Homo sapiens_hsa051680.42521787
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41839396
84Tryptophan metabolism_Homo sapiens_hsa003800.41766454
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41428859
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.39826166
87Carbon metabolism_Homo sapiens_hsa012000.39322885
88Viral myocarditis_Homo sapiens_hsa054160.38892101
89Cell cycle_Homo sapiens_hsa041100.37961596
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35459515
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.34045373
92Steroid biosynthesis_Homo sapiens_hsa001000.33450269
93Apoptosis_Homo sapiens_hsa042100.32965675
94Arachidonic acid metabolism_Homo sapiens_hsa005900.30106763
95Selenocompound metabolism_Homo sapiens_hsa004500.29054745
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27489580
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26254407
98Legionellosis_Homo sapiens_hsa051340.26226155
99Renin-angiotensin system_Homo sapiens_hsa046140.25000975
100Fatty acid metabolism_Homo sapiens_hsa012120.24855447

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