SDHDP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lipopolysaccharide biosynthetic process (GO:0009103)9.07350801
2lipopolysaccharide metabolic process (GO:0008653)8.19980962
3protein-chromophore linkage (GO:0018298)7.29206125
4regulation of protein glycosylation (GO:0060049)6.95070204
5DNA methylation involved in gamete generation (GO:0043046)6.84060735
6regulation of odontogenesis of dentin-containing tooth (GO:0042487)6.77426669
7negative regulation of glycoprotein biosynthetic process (GO:0010561)6.52747215
8regulation of meiosis I (GO:0060631)6.28334133
9phenol-containing compound catabolic process (GO:0019336)5.66389622
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.32674109
11sulfate transmembrane transport (GO:1902358)5.32444863
12positive regulation of developmental pigmentation (GO:0048087)5.28621491
13regulation of pigment cell differentiation (GO:0050932)5.26415104
14negative regulation of glycoprotein metabolic process (GO:1903019)5.12080354
15piRNA metabolic process (GO:0034587)5.09220471
16hormone catabolic process (GO:0042447)5.06827795
17negative regulation of cell cycle G2/M phase transition (GO:1902750)5.01762891
18germinal center formation (GO:0002467)4.78733524
19regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.54403805
20sulfate transport (GO:0008272)4.26511758
21L-phenylalanine catabolic process (GO:0006559)4.21097889
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.21097889
23SMAD protein complex assembly (GO:0007183)4.16979608
24thyroid hormone generation (GO:0006590)4.05508743
25tyrosine metabolic process (GO:0006570)4.02072492
26positive regulation of meiosis (GO:0045836)3.85416374
27regulation of transforming growth factor beta2 production (GO:0032909)3.71815184
28regulation of platelet aggregation (GO:0090330)3.67041841
29heme transport (GO:0015886)3.66549770
30negative regulation of stem cell proliferation (GO:2000647)3.64124678
31cellular modified amino acid catabolic process (GO:0042219)3.55531713
32positive regulation of meiotic cell cycle (GO:0051446)3.52280502
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.49261895
34meiotic chromosome segregation (GO:0045132)3.45056523
35cellular response to zinc ion (GO:0071294)3.42950839
36serotonin receptor signaling pathway (GO:0007210)3.42662585
37thyroid hormone metabolic process (GO:0042403)3.40487211
38regulation of rhodopsin mediated signaling pathway (GO:0022400)3.39525465
39neutrophil activation involved in immune response (GO:0002283)3.37050671
40paraxial mesoderm development (GO:0048339)3.34648210
41negative regulation of neural precursor cell proliferation (GO:2000178)3.34082862
42notochord development (GO:0030903)3.24863326
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.24200386
44L-phenylalanine metabolic process (GO:0006558)3.24200386
45response to mercury ion (GO:0046689)3.16908718
46urate metabolic process (GO:0046415)3.10110939
47rhodopsin mediated signaling pathway (GO:0016056)3.08281310
48protein retention in ER lumen (GO:0006621)3.06185826
49DNA deamination (GO:0045006)3.04857025
50thrombin receptor signaling pathway (GO:0070493)3.02125975
51aromatic amino acid family catabolic process (GO:0009074)3.00082924
52postsynaptic membrane organization (GO:0001941)2.99009768
53pantothenate metabolic process (GO:0015939)2.90265539
54response to epinephrine (GO:0071871)2.88099550
55glycerol metabolic process (GO:0006071)2.87606300
56amine catabolic process (GO:0009310)2.85395667
57cellular biogenic amine catabolic process (GO:0042402)2.85395667
58positive regulation of fatty acid oxidation (GO:0046321)2.83706197
59negative regulation of cell-matrix adhesion (GO:0001953)2.80910884
60regulation of platelet activation (GO:0010543)2.77878145
61cellular response to gamma radiation (GO:0071480)2.75777021
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74556390
63protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)2.74535035
64tachykinin receptor signaling pathway (GO:0007217)2.73791738
65regulation of odontogenesis (GO:0042481)2.69787843
66positive regulation of SMAD protein import into nucleus (GO:0060391)2.67073290
67regulation of gonadotropin secretion (GO:0032276)2.64865800
68lysine catabolic process (GO:0006554)2.61345207
69lysine metabolic process (GO:0006553)2.61345207
70vitamin transmembrane transport (GO:0035461)2.59418991
71heart valve formation (GO:0003188)2.58873485
72uterus development (GO:0060065)2.58331322
73regulation of interleukin-5 production (GO:0032674)2.55894960
74iron coordination entity transport (GO:1901678)2.54773692
75response to interferon-beta (GO:0035456)2.54186257
76positive regulation of mast cell activation (GO:0033005)2.53814516
77polyol biosynthetic process (GO:0046173)2.53148584
78centriole replication (GO:0007099)2.52844647
79regulation of metanephros development (GO:0072215)2.49436858
80aspartate family amino acid catabolic process (GO:0009068)2.47135101
81toxin metabolic process (GO:0009404)2.45321846
82positive regulation of mast cell activation involved in immune response (GO:0033008)2.42824899
83positive regulation of mast cell degranulation (GO:0043306)2.42824899
84epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.41849109
85negative regulation of homotypic cell-cell adhesion (GO:0034111)2.40371431
86alditol metabolic process (GO:0019400)2.39142188
87regulation of SMAD protein import into nucleus (GO:0060390)2.38380529
88cellular response to thyroid hormone stimulus (GO:0097067)2.38371966
89aromatic amino acid family metabolic process (GO:0009072)2.38366851
90membrane lipid biosynthetic process (GO:0046467)2.36771903
91positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.35233494
92response to folic acid (GO:0051593)2.34664524
93negative regulation of thymocyte apoptotic process (GO:0070244)2.33562203
94sulfur compound transport (GO:0072348)2.33308706
95xenobiotic catabolic process (GO:0042178)2.32871542
96indolalkylamine metabolic process (GO:0006586)2.31946718
97regulation of cell adhesion mediated by integrin (GO:0033628)2.27892489
98sphingosine metabolic process (GO:0006670)13.4086980
99diol metabolic process (GO:0034311)12.0077274
100sphingoid metabolic process (GO:0046519)10.7504001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1AR_21572438_ChIP-Seq_LNCaP_Human4.09551556
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.47524159
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.44346075
4IGF1R_20145208_ChIP-Seq_DFB_Human3.31002243
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75853743
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.68426756
7LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.60676981
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.59169464
9GBX2_23144817_ChIP-Seq_PC3_Human2.46084038
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.40514713
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37375786
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.17261987
13SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03038821
14SALL1_21062744_ChIP-ChIP_HESCs_Human1.96193622
15ER_23166858_ChIP-Seq_MCF-7_Human1.93583477
16P300_19829295_ChIP-Seq_ESCs_Human1.80632288
17SOX2_19829295_ChIP-Seq_ESCs_Human1.80387121
18NANOG_19829295_ChIP-Seq_ESCs_Human1.80387121
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80052265
20NFE2_27457419_Chip-Seq_LIVER_Mouse1.76441020
21LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67839758
22GATA2_21666600_ChIP-Seq_HMVEC_Human1.66897614
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65974123
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64537552
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.64084689
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63585964
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61664999
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56443807
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56443807
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55789853
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.55214180
32SCL_19346495_ChIP-Seq_HPC-7_Human1.54777553
33STAT1_20625510_ChIP-Seq_HELA_Human1.53254262
34ZNF274_21170338_ChIP-Seq_K562_Hela1.51792499
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45122451
36CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42749557
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39928444
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.38679990
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35551138
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34504847
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34146139
42OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33988037
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33738970
44EZH2_22144423_ChIP-Seq_EOC_Human1.33094631
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31883317
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31773075
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.30140351
48HOXB7_26014856_ChIP-Seq_BT474_Human1.29680588
49STAT3_23295773_ChIP-Seq_U87_Human1.27933792
50VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26486754
51EGR1_19032775_ChIP-ChIP_M12_Human1.26108964
52AR_25329375_ChIP-Seq_VCAP_Human1.24944464
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24707169
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.23533335
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.23371278
56TCF4_23295773_ChIP-Seq_U87_Human1.23360900
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23200725
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23147098
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21825455
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21176857
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20567039
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17829011
63TP53_16413492_ChIP-PET_HCT116_Human1.15468097
64FOXH1_21741376_ChIP-Seq_ESCs_Human1.13277307
65SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12955939
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10766356
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10167479
68CJUN_26792858_Chip-Seq_BT549_Human1.09516001
69TP53_18474530_ChIP-ChIP_U2OS_Human1.08310480
70VDR_24787735_ChIP-Seq_THP-1_Human1.07622245
71SMAD4_21799915_ChIP-Seq_A2780_Human1.06711672
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06640279
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06261856
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.05798628
75BCAT_22108803_ChIP-Seq_LS180_Human1.05438536
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03452746
77STAT3_18555785_ChIP-Seq_MESCs_Mouse1.02427547
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00351961
79PRDM14_20953172_ChIP-Seq_ESCs_Human0.99999040
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99723938
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.99723938
82TAF15_26573619_Chip-Seq_HEK293_Human0.98266514
83TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97243199
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96781780
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96556287
86GATA3_26560356_Chip-Seq_TH1_Human0.95901031
87TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95845426
88VDR_22108803_ChIP-Seq_LS180_Human0.94786836
89CDX2_22108803_ChIP-Seq_LS180_Human0.94603451
90STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94077588
91OCT4_20526341_ChIP-Seq_ESCs_Human0.93861295
92SMAD4_21741376_ChIP-Seq_EPCs_Human0.93703553
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93617780
94RXR_22108803_ChIP-Seq_LS180_Human0.93501474
95SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93478176
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91882399
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91204167
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90797769
99SPI1_20517297_ChIP-Seq_HL60_Human0.89920712
100CEBPB_22108803_ChIP-Seq_LS180_Human0.89202344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.45633238
2MP0003136_yellow_coat_color7.10020235
3MP0005171_absent_coat_pigmentation6.96923827
4MP0002653_abnormal_ependyma_morphology5.34402621
5MP0003045_fibrosis4.39195477
6MP0000569_abnormal_digit_pigmentation3.84427273
7MP0003646_muscle_fatigue3.33891029
8MP0003890_abnormal_embryonic-extraembry2.54917889
9MP0004381_abnormal_hair_follicle2.53881037
10MP0003879_abnormal_hair_cell2.39640154
11MP0005085_abnormal_gallbladder_physiolo2.34652805
12MP0005670_abnormal_white_adipose2.22178523
13MP0002138_abnormal_hepatobiliary_system2.18503832
14MP0006054_spinal_hemorrhage2.13405888
15MP0005464_abnormal_platelet_physiology1.90347893
16MP0000749_muscle_degeneration1.87647705
17MP0002168_other_aberrant_phenotype1.77444700
18MP0005075_abnormal_melanosome_morpholog1.73922032
19MP0004147_increased_porphyrin_level1.70347270
20MP0005174_abnormal_tail_pigmentation1.49803675
21MP0002736_abnormal_nociception_after1.49059332
22MP0005365_abnormal_bile_salt1.48483873
23MP0003011_delayed_dark_adaptation1.45373186
24MP0009764_decreased_sensitivity_to1.41470929
25MP0003300_gastrointestinal_ulcer1.36854373
26MP0004043_abnormal_pH_regulation1.36089593
27MP0003950_abnormal_plasma_membrane1.24368572
28MP0002095_abnormal_skin_pigmentation1.23837267
29MP0002735_abnormal_chemical_nociception1.20090983
30MP0003724_increased_susceptibility_to1.19048762
31MP0002938_white_spotting1.17349789
32MP0003868_abnormal_feces_composition1.14957538
33MP0001501_abnormal_sleep_pattern1.12340746
34MP0008004_abnormal_stomach_pH1.08248172
35MP0003705_abnormal_hypodermis_morpholog1.07093699
36MP0002638_abnormal_pupillary_reflex0.99367902
37MP0003252_abnormal_bile_duct0.99078349
38MP0010352_gastrointestinal_tract_polyps0.96718104
39MP0000383_abnormal_hair_follicle0.95848677
40MP0001984_abnormal_olfaction0.95455381
41MP0008872_abnormal_physiological_respon0.95230527
42MP0005395_other_phenotype0.93203514
43MP0002160_abnormal_reproductive_system0.92875542
44MP0008569_lethality_at_weaning0.92333999
45MP0001968_abnormal_touch/_nociception0.91711941
46MP0001970_abnormal_pain_threshold0.89745596
47MP0002733_abnormal_thermal_nociception0.89527410
48MP0003195_calcinosis0.88388365
49MP0001661_extended_life_span0.88347738
50MP0010329_abnormal_lipoprotein_level0.87729967
51MP0000015_abnormal_ear_pigmentation0.86754948
52MP0000427_abnormal_hair_cycle0.86249048
53MP0001835_abnormal_antigen_presentation0.84347273
54MP0001800_abnormal_humoral_immune0.84002402
55MP0005410_abnormal_fertilization0.83827134
56MP0002075_abnormal_coat/hair_pigmentati0.79380572
57MP0002132_abnormal_respiratory_system0.78691891
58MP0002254_reproductive_system_inflammat0.77481998
59MP0001324_abnormal_eye_pigmentation0.71384556
60MP0004233_abnormal_muscle_weight0.70161515
61MP0002452_abnormal_antigen_presenting0.68208266
62MP0005319_abnormal_enzyme/_coenzyme0.67520901
63MP0002269_muscular_atrophy0.63452064
64MP0002419_abnormal_innate_immunity0.62825197
65MP0000230_abnormal_systemic_arterial0.62415094
66MP0002277_abnormal_respiratory_mucosa0.62167715
67MP0005646_abnormal_pituitary_gland0.61872760
68MP0003186_abnormal_redox_activity0.60988725
69MP0001845_abnormal_inflammatory_respons0.60936321
70MP0005551_abnormal_eye_electrophysiolog0.60773233
71MP0008469_abnormal_protein_level0.60476896
72MP0008874_decreased_physiological_sensi0.59642353
73MP0002332_abnormal_exercise_endurance0.58921959
74MP0004484_altered_response_of0.57938485
75MP0005076_abnormal_cell_differentiation0.57840509
76MP0001790_abnormal_immune_system0.57339661
77MP0005387_immune_system_phenotype0.57339661
78MP0005000_abnormal_immune_tolerance0.57030689
79MP0002148_abnormal_hypersensitivity_rea0.56733641
80MP0009763_increased_sensitivity_to0.56257450
81MP0003303_peritoneal_inflammation0.56244989
82MP0002723_abnormal_immune_serum0.54530228
83MP0003137_abnormal_impulse_conducting0.53724816
84MP0003279_aneurysm0.53057963
85MP0000343_altered_response_to0.52087897
86MP0005389_reproductive_system_phenotype0.51932172
87MP0001986_abnormal_taste_sensitivity0.50707580
88MP0005584_abnormal_enzyme/coenzyme_acti0.50462935
89MP0005025_abnormal_response_to0.50027189
90MP0002272_abnormal_nervous_system0.47428186
91MP0004130_abnormal_muscle_cell0.47381482
92MP0000920_abnormal_myelination0.46076305
93MP0002971_abnormal_brown_adipose0.44178001
94MP0002420_abnormal_adaptive_immunity0.43999330
95MP0002722_abnormal_immune_system0.42726104
96MP0003183_abnormal_peptide_metabolism0.42554119
97MP0001486_abnormal_startle_reflex0.42074596
98MP0002876_abnormal_thyroid_physiology0.41303797
99MP0003075_altered_response_to0.40446960
100MP0002118_abnormal_lipid_homeostasis0.39856689

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)7.67177029
2Focal motor seizures (HP:0011153)7.48228069
3Acanthocytosis (HP:0001927)6.69067185
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.51356228
5Parakeratosis (HP:0001036)5.73247185
6Spontaneous hematomas (HP:0007420)5.46099415
7Petechiae (HP:0000967)5.35724177
8Hematochezia (HP:0002573)5.02057128
9Ulnar claw (HP:0001178)4.43625804
10Conjunctival telangiectasia (HP:0000524)4.39249537
11Aplastic anemia (HP:0001915)4.19204755
12Purpura (HP:0000979)4.06950164
13Rectal prolapse (HP:0002035)3.94997785
14Albinism (HP:0001022)3.85420682
15Dialeptic seizures (HP:0011146)3.78727788
16Abnormality of the vasculature of the conjunctiva (HP:0008054)3.76947897
17Poikilocytosis (HP:0004447)3.65423174
18Erythroderma (HP:0001019)3.30410867
19Congenital ichthyosiform erythroderma (HP:0007431)3.28321417
20Prolonged bleeding time (HP:0003010)3.25517608
21Colon cancer (HP:0003003)3.23670798
22Focal seizures (HP:0007359)3.19818400
23Difficulty walking (HP:0002355)3.14427393
24Vertebral arch anomaly (HP:0008438)3.04470598
25Proximal amyotrophy (HP:0007126)3.02386618
26Abnormality of the vocal cords (HP:0008777)3.01962274
27Epistaxis (HP:0000421)3.00584864
28Esophageal varix (HP:0002040)2.88494590
29Progressive inability to walk (HP:0002505)2.74466941
30Menorrhagia (HP:0000132)2.73806781
31Autoimmune hemolytic anemia (HP:0001890)2.73623200
32Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72539524
33Hypoplastic iliac wings (HP:0002866)2.55300800
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.50094745
35Portal hypertension (HP:0001409)2.49111854
36Scapular winging (HP:0003691)2.46568950
37Gangrene (HP:0100758)2.45524339
38Potter facies (HP:0002009)2.42374860
39Facial shape deformation (HP:0011334)2.42374860
40Hyperlipoproteinemia (HP:0010980)2.38327329
41Pancreatic cysts (HP:0001737)2.37290569
42Broad ribs (HP:0000885)2.36150379
43Retinitis pigmentosa (HP:0000510)2.32104139
44Bilateral sensorineural hearing impairment (HP:0008619)2.31551452
45Abnormality of the renal cortex (HP:0011035)2.30720362
46Type I transferrin isoform profile (HP:0003642)2.29947338
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29630201
48Abnormality of the hepatic vasculature (HP:0006707)2.20856932
49IgM deficiency (HP:0002850)2.14744932
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.14447955
51Microcytic anemia (HP:0001935)2.10657217
52Opisthotonus (HP:0002179)2.10339514
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.09127020
54Onion bulb formation (HP:0003383)2.07219239
55Follicular hyperkeratosis (HP:0007502)2.06928572
56Polycythemia (HP:0001901)2.06723702
57Gingival bleeding (HP:0000225)2.05474018
58Neonatal respiratory distress (HP:0002643)2.04593041
59Facial diplegia (HP:0001349)2.04277564
60Elevated erythrocyte sedimentation rate (HP:0003565)2.04253017
61Increased cerebral lipofuscin (HP:0011813)1.99650233
62Peripheral hypomyelination (HP:0007182)1.96165942
63Colitis (HP:0002583)1.92273672
64Abnormality of the wing of the ilium (HP:0011867)1.91788252
65Enlarged kidneys (HP:0000105)1.88365773
66Abnormality of the renal medulla (HP:0100957)1.88079826
67Pulmonary embolism (HP:0002204)1.82799930
68Dehydration (HP:0001944)1.82685584
69Chronic diarrhea (HP:0002028)1.81785539
70Ulnar bowing (HP:0003031)1.81619073
71Recurrent sinusitis (HP:0011108)1.80717545
72Abnormal platelet volume (HP:0011876)1.80541252
73Abnormality of macular pigmentation (HP:0008002)1.79059231
74Acute hepatic failure (HP:0006554)1.78752903
75Asymmetric septal hypertrophy (HP:0001670)1.77393432
76Abnormality of binocular vision (HP:0011514)1.76782137
77Diplopia (HP:0000651)1.76782137
78Abnormal delayed hypersensitivity skin test (HP:0002963)1.75307833
79Ileus (HP:0002595)1.74925428
80Radial bowing (HP:0002986)1.74877149
81Increased mean platelet volume (HP:0011877)1.74199321
82Lack of skin elasticity (HP:0100679)1.73151138
83Hypoplasia of the odontoid process (HP:0003311)1.71553537
84Renal tubular acidosis (HP:0001947)1.71425710
85Tubulointerstitial fibrosis (HP:0005576)1.71351207
86Stomatitis (HP:0010280)1.70312814
87Segmental peripheral demyelination/remyelination (HP:0003481)1.67314517
88Congenital stationary night blindness (HP:0007642)1.66908269
89Severe visual impairment (HP:0001141)1.66416542
90Synostosis involving bones of the feet (HP:0009140)1.65989209
91Synostosis involving bones of the lower limbs (HP:0009138)1.65989209
92Synostosis of carpal bones (HP:0005048)1.64680738
93Inability to walk (HP:0002540)1.63501235
94Spastic paraparesis (HP:0002313)1.63433084
95Hypoproteinemia (HP:0003075)1.63200656
96Hemoptysis (HP:0002105)1.62889767
97Hematuria (HP:0000790)1.62631903
98Steppage gait (HP:0003376)1.59244596
99Nonprogressive disorder (HP:0003680)1.59147059
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58694573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS19.66021433
2STK38L6.71821530
3LATS26.08170822
4STK382.85907295
5ACVR1B2.58223511
6FRK2.48843890
7NLK2.29483877
8PRKD32.24183498
9KSR22.10225349
10MAP2K22.01092091
11ZAK2.01085492
12STK31.98278385
13BMPR1B1.90687577
14PIK3CG1.62882522
15TAOK31.62855014
16MELK1.46963317
17MAP3K31.16025092
18MAP3K21.14569255
19LMTK21.00731374
20PRKD10.99376740
21IRAK30.98224802
22PRKAA20.94956575
23PDPK10.93532072
24EIF2AK30.91964659
25GRK70.91171047
26PINK10.89013130
27TEC0.86447476
28DAPK20.81261567
29KIT0.81059855
30ADRBK20.77624107
31ADRBK10.75375324
32TNK20.74405945
33TAOK10.67919337
34RIPK40.67571593
35RAF10.67285372
36MAP2K10.66629276
37GRK50.65599933
38PIM20.65488171
39TGFBR10.65144876
40IRAK40.60715385
41PTK2B0.60467007
42CSF1R0.58141516
43BTK0.57862430
44MAP4K20.57321883
45CSNK1A1L0.57285449
46FES0.56189734
47TGFBR20.52112283
48CSK0.49683286
49ERN10.49052151
50JAK30.47136856
51JAK20.44838145
52STK110.43490687
53NEK90.42567423
54HCK0.42334511
55TXK0.41688725
56MAP2K30.41009651
57PLK20.40973552
58PRKG20.40081398
59ITK0.38974053
60MAP4K10.38792423
61TYK20.38031911
62MATK0.37860817
63MAPKAPK30.37667915
64SYK0.36190209
65MOS0.34571706
66GRK60.33910173
67FGR0.33468319
68PAK30.33437753
69PAK60.33327546
70MAPK130.31226494
71IKBKB0.30325863
72LYN0.29088086
73NEK20.28612537
74ABL10.27935585
75NME10.27752497
76MAP3K10.27719522
77GRK10.27258042
78PRKCE0.26337323
79PIM10.25259294
80KSR10.24759267
81IRAK10.24065867
82STK240.24040427
83BLK0.23371706
84BMX0.22237999
85MAPK30.21884625
86ARAF0.21206370
87TAOK20.18049741
88BCKDK0.16969006
89FER0.16620537
90PRKACA0.16454529
91PRKACG0.16153790
92RET0.14930993
93IKBKE0.14874208
94NTRK30.12519406
95CSNK1D0.12419993
96ZAP700.12112458
97PRKCI0.09257713
98LCK0.09075777
99TAF10.08074461
100FLT30.07465974

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.34760047
2Phototransduction_Homo sapiens_hsa047443.90336435
3Sphingolipid metabolism_Homo sapiens_hsa006003.57436853
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.52831265
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.26331810
6Dorso-ventral axis formation_Homo sapiens_hsa043202.92838330
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.33524163
8Nicotine addiction_Homo sapiens_hsa050332.28836408
9Phenylalanine metabolism_Homo sapiens_hsa003601.97010612
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85046621
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79105445
12Taste transduction_Homo sapiens_hsa047421.75446975
13Morphine addiction_Homo sapiens_hsa050321.65295661
14Nitrogen metabolism_Homo sapiens_hsa009101.56060114
15Histidine metabolism_Homo sapiens_hsa003401.54185372
16Platelet activation_Homo sapiens_hsa046111.41433226
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39986648
18N-Glycan biosynthesis_Homo sapiens_hsa005101.39645102
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35392352
20Tryptophan metabolism_Homo sapiens_hsa003801.35046067
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31467872
22One carbon pool by folate_Homo sapiens_hsa006701.31234025
23Glycerolipid metabolism_Homo sapiens_hsa005611.15760858
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12952077
25Viral myocarditis_Homo sapiens_hsa054161.12228907
26African trypanosomiasis_Homo sapiens_hsa051431.12072656
27Calcium signaling pathway_Homo sapiens_hsa040201.11562999
28GABAergic synapse_Homo sapiens_hsa047271.11086350
29Hematopoietic cell lineage_Homo sapiens_hsa046401.10076039
30beta-Alanine metabolism_Homo sapiens_hsa004101.08494108
31Sphingolipid signaling pathway_Homo sapiens_hsa040711.07400963
32ABC transporters_Homo sapiens_hsa020101.06614367
33Arachidonic acid metabolism_Homo sapiens_hsa005901.05445740
34ECM-receptor interaction_Homo sapiens_hsa045121.05292910
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01967538
36VEGF signaling pathway_Homo sapiens_hsa043701.01308805
37Tuberculosis_Homo sapiens_hsa051521.00300419
38Serotonergic synapse_Homo sapiens_hsa047260.98006543
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94038882
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91065819
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88242853
42Glutamatergic synapse_Homo sapiens_hsa047240.86871557
43Glutathione metabolism_Homo sapiens_hsa004800.85265773
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84234822
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.81904854
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79459950
47Olfactory transduction_Homo sapiens_hsa047400.75907433
48Arginine and proline metabolism_Homo sapiens_hsa003300.74837749
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.71835788
50Staphylococcus aureus infection_Homo sapiens_hsa051500.71792431
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.68584083
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68494452
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.66663806
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.66599845
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64988221
56Dilated cardiomyopathy_Homo sapiens_hsa054140.64953416
57Chemical carcinogenesis_Homo sapiens_hsa052040.58206453
58cAMP signaling pathway_Homo sapiens_hsa040240.57041369
59Bile secretion_Homo sapiens_hsa049760.56634606
60Complement and coagulation cascades_Homo sapiens_hsa046100.56115031
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55817914
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55435971
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55306219
64Ovarian steroidogenesis_Homo sapiens_hsa049130.54471765
65Malaria_Homo sapiens_hsa051440.53754318
66Tyrosine metabolism_Homo sapiens_hsa003500.51048399
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50987848
68Butanoate metabolism_Homo sapiens_hsa006500.50913694
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49456322
70Propanoate metabolism_Homo sapiens_hsa006400.45740480
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44887182
72Chemokine signaling pathway_Homo sapiens_hsa040620.44548138
73Sulfur metabolism_Homo sapiens_hsa009200.42853694
74Linoleic acid metabolism_Homo sapiens_hsa005910.42091421
75Primary immunodeficiency_Homo sapiens_hsa053400.40080396
76Pancreatic cancer_Homo sapiens_hsa052120.39636098
77Vitamin digestion and absorption_Homo sapiens_hsa049770.38964140
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38918576
79TGF-beta signaling pathway_Homo sapiens_hsa043500.34405899
80Osteoclast differentiation_Homo sapiens_hsa043800.33573452
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32914316
82Peroxisome_Homo sapiens_hsa041460.32603050
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32529846
84Collecting duct acid secretion_Homo sapiens_hsa049660.32174479
85Circadian entrainment_Homo sapiens_hsa047130.31156368
86Fatty acid elongation_Homo sapiens_hsa000620.31151146
87Autoimmune thyroid disease_Homo sapiens_hsa053200.30997196
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30414019
89Mineral absorption_Homo sapiens_hsa049780.30043184
90Lysosome_Homo sapiens_hsa041420.29914459
91Fatty acid degradation_Homo sapiens_hsa000710.29819382
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28565060
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.26257513
94Graft-versus-host disease_Homo sapiens_hsa053320.25630742
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25474900
96Colorectal cancer_Homo sapiens_hsa052100.25213378
97Gap junction_Homo sapiens_hsa045400.25085344
98Allograft rejection_Homo sapiens_hsa053300.24275485
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.22938935
100Leishmaniasis_Homo sapiens_hsa051400.21527287

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