ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	lipopolysaccharide biosynthetic process (GO:0009103)	9.07350801
2	lipopolysaccharide metabolic process (GO:0008653)	8.19980962
3	protein-chromophore linkage (GO:0018298)	7.29206125
4	regulation of protein glycosylation (GO:0060049)	6.95070204
5	DNA methylation involved in gamete generation (GO:0043046)	6.84060735
6	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	6.77426669
7	negative regulation of glycoprotein biosynthetic process (GO:0010561)	6.52747215
8	regulation of meiosis I (GO:0060631)	6.28334133
9	phenol-containing compound catabolic process (GO:0019336)	5.66389622
10	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	5.32674109
11	sulfate transmembrane transport (GO:1902358)	5.32444863
12	positive regulation of developmental pigmentation (GO:0048087)	5.28621491
13	regulation of pigment cell differentiation (GO:0050932)	5.26415104
14	negative regulation of glycoprotein metabolic process (GO:1903019)	5.12080354
15	piRNA metabolic process (GO:0034587)	5.09220471
16	hormone catabolic process (GO:0042447)	5.06827795
17	negative regulation of cell cycle G2/M phase transition (GO:1902750)	5.01762891
18	germinal center formation (GO:0002467)	4.78733524
19	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	4.54403805
20	sulfate transport (GO:0008272)	4.26511758
21	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.21097889
22	L-phenylalanine catabolic process (GO:0006559)	4.21097889
23	SMAD protein complex assembly (GO:0007183)	4.16979608
24	thyroid hormone generation (GO:0006590)	4.05508743
25	tyrosine metabolic process (GO:0006570)	4.02072492
26	positive regulation of meiosis (GO:0045836)	3.85416374
27	regulation of transforming growth factor beta2 production (GO:0032909)	3.71815184
28	regulation of platelet aggregation (GO:0090330)	3.67041841
29	heme transport (GO:0015886)	3.66549770
30	negative regulation of stem cell proliferation (GO:2000647)	3.64124678
31	cellular modified amino acid catabolic process (GO:0042219)	3.55531713
32	positive regulation of meiotic cell cycle (GO:0051446)	3.52280502
33	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.49261895
34	meiotic chromosome segregation (GO:0045132)	3.45056523
35	cellular response to zinc ion (GO:0071294)	3.42950839
36	serotonin receptor signaling pathway (GO:0007210)	3.42662585
37	thyroid hormone metabolic process (GO:0042403)	3.40487211
38	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.39525465
39	neutrophil activation involved in immune response (GO:0002283)	3.37050671
40	paraxial mesoderm development (GO:0048339)	3.34648210
41	negative regulation of neural precursor cell proliferation (GO:2000178)	3.34082862
42	notochord development (GO:0030903)	3.24863326
43	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.24200386
44	L-phenylalanine metabolic process (GO:0006558)	3.24200386
45	response to mercury ion (GO:0046689)	3.16908718
46	urate metabolic process (GO:0046415)	3.10110939
47	rhodopsin mediated signaling pathway (GO:0016056)	3.08281310
48	protein retention in ER lumen (GO:0006621)	3.06185826
49	DNA deamination (GO:0045006)	3.04857025
50	thrombin receptor signaling pathway (GO:0070493)	3.02125975
51	aromatic amino acid family catabolic process (GO:0009074)	3.00082924
52	postsynaptic membrane organization (GO:0001941)	2.99009768
53	pantothenate metabolic process (GO:0015939)	2.90265539
54	response to epinephrine (GO:0071871)	2.88099550
55	glycerol metabolic process (GO:0006071)	2.87606300
56	cellular biogenic amine catabolic process (GO:0042402)	2.85395667
57	amine catabolic process (GO:0009310)	2.85395667
58	positive regulation of fatty acid oxidation (GO:0046321)	2.83706197
59	negative regulation of cell-matrix adhesion (GO:0001953)	2.80910884
60	regulation of platelet activation (GO:0010543)	2.77878145
61	cellular response to gamma radiation (GO:0071480)	2.75777021
62	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.74556390
63	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	2.74535035
64	tachykinin receptor signaling pathway (GO:0007217)	2.73791738
65	regulation of odontogenesis (GO:0042481)	2.69787843
66	positive regulation of SMAD protein import into nucleus (GO:0060391)	2.67073290
67	regulation of gonadotropin secretion (GO:0032276)	2.64865800
68	lysine metabolic process (GO:0006553)	2.61345207
69	lysine catabolic process (GO:0006554)	2.61345207
70	vitamin transmembrane transport (GO:0035461)	2.59418991
71	heart valve formation (GO:0003188)	2.58873485
72	uterus development (GO:0060065)	2.58331322
73	regulation of interleukin-5 production (GO:0032674)	2.55894960
74	iron coordination entity transport (GO:1901678)	2.54773692
75	response to interferon-beta (GO:0035456)	2.54186257
76	positive regulation of mast cell activation (GO:0033005)	2.53814516
77	polyol biosynthetic process (GO:0046173)	2.53148584
78	centriole replication (GO:0007099)	2.52844647
79	regulation of metanephros development (GO:0072215)	2.49436858
80	aspartate family amino acid catabolic process (GO:0009068)	2.47135101
81	toxin metabolic process (GO:0009404)	2.45321846
82	positive regulation of mast cell degranulation (GO:0043306)	2.42824899
83	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.42824899
84	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.41849109
85	negative regulation of homotypic cell-cell adhesion (GO:0034111)	2.40371431
86	alditol metabolic process (GO:0019400)	2.39142188
87	regulation of SMAD protein import into nucleus (GO:0060390)	2.38380529
88	cellular response to thyroid hormone stimulus (GO:0097067)	2.38371966
89	aromatic amino acid family metabolic process (GO:0009072)	2.38366851
90	membrane lipid biosynthetic process (GO:0046467)	2.36771903
91	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.35233494
92	response to folic acid (GO:0051593)	2.34664524
93	negative regulation of thymocyte apoptotic process (GO:0070244)	2.33562203
94	sulfur compound transport (GO:0072348)	2.33308706
95	xenobiotic catabolic process (GO:0042178)	2.32871542
96	indolalkylamine metabolic process (GO:0006586)	2.31946718
97	regulation of cell adhesion mediated by integrin (GO:0033628)	2.27892489
98	sphingosine metabolic process (GO:0006670)	13.4086980
99	diol metabolic process (GO:0034311)	12.0077274
100	sphingoid metabolic process (GO:0046519)	10.7504001

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	4.09551556
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.47524159
3	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.44346075
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.31002243
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.75853743
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.68426756
7	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.60676981
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.59169464
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.46084038
10	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.40514713
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.37375786
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17261987
13	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.03038821
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.96193622
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.93583477
16	P300_19829295_ChIP-Seq_ESCs_Human	1.80632288
17	SOX2_19829295_ChIP-Seq_ESCs_Human	1.80387121
18	NANOG_19829295_ChIP-Seq_ESCs_Human	1.80387121
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80052265
20	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.76441020
21	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.67839758
22	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.66897614
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.65974123
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.64537552
25	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.64084689
26	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.63585964
27	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.61664999
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56443807
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56443807
30	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.55789853
31	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.55214180
32	SCL_19346495_ChIP-Seq_HPC-7_Human	1.54777553
33	STAT1_20625510_ChIP-Seq_HELA_Human	1.53254262
34	ZNF274_21170338_ChIP-Seq_K562_Hela	1.51792499
35	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.45122451
36	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.42749557
37	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.39928444
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38679990
39	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.35551138
40	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.34504847
41	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.34146139
42	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.33988037
43	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.33738970
44	EZH2_22144423_ChIP-Seq_EOC_Human	1.33094631
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31883317
46	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.31773075
47	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.30140351
48	HOXB7_26014856_ChIP-Seq_BT474_Human	1.29680588
49	STAT3_23295773_ChIP-Seq_U87_Human	1.27933792
50	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.26486754
51	EGR1_19032775_ChIP-ChIP_M12_Human	1.26108964
52	AR_25329375_ChIP-Seq_VCAP_Human	1.24944464
53	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.24707169
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23533335
55	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.23371278
56	TCF4_23295773_ChIP-Seq_U87_Human	1.23360900
57	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.23200725
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.23147098
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21825455
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21176857
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20567039
62	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.17829011
63	TP53_16413492_ChIP-PET_HCT116_Human	1.15468097
64	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.13277307
65	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.12955939
66	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.10766356
67	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.10167479
68	CJUN_26792858_Chip-Seq_BT549_Human	1.09516001
69	TP53_18474530_ChIP-ChIP_U2OS_Human	1.08310480
70	VDR_24787735_ChIP-Seq_THP-1_Human	1.07622245
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.06711672
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06640279
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06261856
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05798628
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.05438536
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03452746
77	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.02427547
78	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.00351961
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99999040
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99723938
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99723938
82	TAF15_26573619_Chip-Seq_HEK293_Human	0.98266514
83	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.97243199
84	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96781780
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96556287
86	GATA3_26560356_Chip-Seq_TH1_Human	0.95901031
87	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.95845426
88	VDR_22108803_ChIP-Seq_LS180_Human	0.94786836
89	CDX2_22108803_ChIP-Seq_LS180_Human	0.94603451
90	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.94077588
91	OCT4_20526341_ChIP-Seq_ESCs_Human	0.93861295
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93703553
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93617780
94	RXR_22108803_ChIP-Seq_LS180_Human	0.93501474
95	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.93478176
96	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.91882399
97	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.91204167
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.90797769
99	SPI1_20517297_ChIP-Seq_HL60_Human	0.89920712
100	CEBPB_22108803_ChIP-Seq_LS180_Human	0.89202344

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	7.45633238
2	MP0003136_yellow_coat_color	7.10020235
3	MP0005171_absent_coat_pigmentation	6.96923827
4	MP0002653_abnormal_ependyma_morphology	5.34402621
5	MP0003045_fibrosis	4.39195477
6	MP0000569_abnormal_digit_pigmentation	3.84427273
7	MP0003646_muscle_fatigue	3.33891029
8	MP0003890_abnormal_embryonic-extraembry	2.54917889
9	MP0004381_abnormal_hair_follicle	2.53881037
10	MP0003879_abnormal_hair_cell	2.39640154
11	MP0005085_abnormal_gallbladder_physiolo	2.34652805
12	MP0005670_abnormal_white_adipose	2.22178523
13	MP0002138_abnormal_hepatobiliary_system	2.18503832
14	MP0006054_spinal_hemorrhage	2.13405888
15	MP0005464_abnormal_platelet_physiology	1.90347893
16	MP0000749_muscle_degeneration	1.87647705
17	MP0002168_other_aberrant_phenotype	1.77444700
18	MP0005075_abnormal_melanosome_morpholog	1.73922032
19	MP0004147_increased_porphyrin_level	1.70347270
20	MP0005174_abnormal_tail_pigmentation	1.49803675
21	MP0002736_abnormal_nociception_after	1.49059332
22	MP0005365_abnormal_bile_salt	1.48483873
23	MP0003011_delayed_dark_adaptation	1.45373186
24	MP0009764_decreased_sensitivity_to	1.41470929
25	MP0003300_gastrointestinal_ulcer	1.36854373
26	MP0004043_abnormal_pH_regulation	1.36089593
27	MP0003950_abnormal_plasma_membrane	1.24368572
28	MP0002095_abnormal_skin_pigmentation	1.23837267
29	MP0002735_abnormal_chemical_nociception	1.20090983
30	MP0003724_increased_susceptibility_to	1.19048762
31	MP0002938_white_spotting	1.17349789
32	MP0003868_abnormal_feces_composition	1.14957538
33	MP0001501_abnormal_sleep_pattern	1.12340746
34	MP0008004_abnormal_stomach_pH	1.08248172
35	MP0003705_abnormal_hypodermis_morpholog	1.07093699
36	MP0002638_abnormal_pupillary_reflex	0.99367902
37	MP0003252_abnormal_bile_duct	0.99078349
38	MP0010352_gastrointestinal_tract_polyps	0.96718104
39	MP0000383_abnormal_hair_follicle	0.95848677
40	MP0001984_abnormal_olfaction	0.95455381
41	MP0008872_abnormal_physiological_respon	0.95230527
42	MP0005395_other_phenotype	0.93203514
43	MP0002160_abnormal_reproductive_system	0.92875542
44	MP0008569_lethality_at_weaning	0.92333999
45	MP0001968_abnormal_touch/_nociception	0.91711941
46	MP0001970_abnormal_pain_threshold	0.89745596
47	MP0002733_abnormal_thermal_nociception	0.89527410
48	MP0003195_calcinosis	0.88388365
49	MP0001661_extended_life_span	0.88347738
50	MP0010329_abnormal_lipoprotein_level	0.87729967
51	MP0000015_abnormal_ear_pigmentation	0.86754948
52	MP0000427_abnormal_hair_cycle	0.86249048
53	MP0001835_abnormal_antigen_presentation	0.84347273
54	MP0001800_abnormal_humoral_immune	0.84002402
55	MP0005410_abnormal_fertilization	0.83827134
56	MP0002075_abnormal_coat/hair_pigmentati	0.79380572
57	MP0002132_abnormal_respiratory_system	0.78691891
58	MP0002254_reproductive_system_inflammat	0.77481998
59	MP0001324_abnormal_eye_pigmentation	0.71384556
60	MP0004233_abnormal_muscle_weight	0.70161515
61	MP0002452_abnormal_antigen_presenting	0.68208266
62	MP0005319_abnormal_enzyme/_coenzyme	0.67520901
63	MP0002269_muscular_atrophy	0.63452064
64	MP0002419_abnormal_innate_immunity	0.62825197
65	MP0000230_abnormal_systemic_arterial	0.62415094
66	MP0002277_abnormal_respiratory_mucosa	0.62167715
67	MP0005646_abnormal_pituitary_gland	0.61872760
68	MP0003186_abnormal_redox_activity	0.60988725
69	MP0001845_abnormal_inflammatory_respons	0.60936321
70	MP0005551_abnormal_eye_electrophysiolog	0.60773233
71	MP0008469_abnormal_protein_level	0.60476896
72	MP0008874_decreased_physiological_sensi	0.59642353
73	MP0002332_abnormal_exercise_endurance	0.58921959
74	MP0004484_altered_response_of	0.57938485
75	MP0005076_abnormal_cell_differentiation	0.57840509
76	MP0001790_abnormal_immune_system	0.57339661
77	MP0005387_immune_system_phenotype	0.57339661
78	MP0005000_abnormal_immune_tolerance	0.57030689
79	MP0002148_abnormal_hypersensitivity_rea	0.56733641
80	MP0009763_increased_sensitivity_to	0.56257450
81	MP0003303_peritoneal_inflammation	0.56244989
82	MP0002723_abnormal_immune_serum	0.54530228
83	MP0003137_abnormal_impulse_conducting	0.53724816
84	MP0003279_aneurysm	0.53057963
85	MP0000343_altered_response_to	0.52087897
86	MP0005389_reproductive_system_phenotype	0.51932172
87	MP0001986_abnormal_taste_sensitivity	0.50707580
88	MP0005584_abnormal_enzyme/coenzyme_acti	0.50462935
89	MP0005025_abnormal_response_to	0.50027189
90	MP0002272_abnormal_nervous_system	0.47428186
91	MP0004130_abnormal_muscle_cell	0.47381482
92	MP0000920_abnormal_myelination	0.46076305
93	MP0002971_abnormal_brown_adipose	0.44178001
94	MP0002420_abnormal_adaptive_immunity	0.43999330
95	MP0002722_abnormal_immune_system	0.42726104
96	MP0003183_abnormal_peptide_metabolism	0.42554119
97	MP0001486_abnormal_startle_reflex	0.42074596
98	MP0002876_abnormal_thyroid_physiology	0.41303797
99	MP0003075_altered_response_to	0.40446960
100	MP0002118_abnormal_lipid_homeostasis	0.39856689

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amelogenesis imperfecta (HP:0000705)	7.67177029
2	Focal motor seizures (HP:0011153)	7.48228069
3	Acanthocytosis (HP:0001927)	6.69067185
4	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	6.51356228
5	Parakeratosis (HP:0001036)	5.73247185
6	Spontaneous hematomas (HP:0007420)	5.46099415
7	Petechiae (HP:0000967)	5.35724177
8	Hematochezia (HP:0002573)	5.02057128
9	Ulnar claw (HP:0001178)	4.43625804
10	Conjunctival telangiectasia (HP:0000524)	4.39249537
11	Aplastic anemia (HP:0001915)	4.19204755
12	Purpura (HP:0000979)	4.06950164
13	Rectal prolapse (HP:0002035)	3.94997785
14	Albinism (HP:0001022)	3.85420682
15	Dialeptic seizures (HP:0011146)	3.78727788
16	Abnormality of the vasculature of the conjunctiva (HP:0008054)	3.76947897
17	Poikilocytosis (HP:0004447)	3.65423174
18	Erythroderma (HP:0001019)	3.30410867
19	Congenital ichthyosiform erythroderma (HP:0007431)	3.28321417
20	Prolonged bleeding time (HP:0003010)	3.25517608
21	Colon cancer (HP:0003003)	3.23670798
22	Focal seizures (HP:0007359)	3.19818400
23	Difficulty walking (HP:0002355)	3.14427393
24	Vertebral arch anomaly (HP:0008438)	3.04470598
25	Proximal amyotrophy (HP:0007126)	3.02386618
26	Abnormality of the vocal cords (HP:0008777)	3.01962274
27	Epistaxis (HP:0000421)	3.00584864
28	Esophageal varix (HP:0002040)	2.88494590
29	Progressive inability to walk (HP:0002505)	2.74466941
30	Menorrhagia (HP:0000132)	2.73806781
31	Autoimmune hemolytic anemia (HP:0001890)	2.73623200
32	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.72539524
33	Hypoplastic iliac wings (HP:0002866)	2.55300800
34	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.50094745
35	Portal hypertension (HP:0001409)	2.49111854
36	Scapular winging (HP:0003691)	2.46568950
37	Gangrene (HP:0100758)	2.45524339
38	Potter facies (HP:0002009)	2.42374860
39	Facial shape deformation (HP:0011334)	2.42374860
40	Hyperlipoproteinemia (HP:0010980)	2.38327329
41	Pancreatic cysts (HP:0001737)	2.37290569
42	Broad ribs (HP:0000885)	2.36150379
43	Retinitis pigmentosa (HP:0000510)	2.32104139
44	Bilateral sensorineural hearing impairment (HP:0008619)	2.31551452
45	Abnormality of the renal cortex (HP:0011035)	2.30720362
46	Type I transferrin isoform profile (HP:0003642)	2.29947338
47	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.29630201
48	Abnormality of the hepatic vasculature (HP:0006707)	2.20856932
49	IgM deficiency (HP:0002850)	2.14744932
50	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.14447955
51	Microcytic anemia (HP:0001935)	2.10657217
52	Opisthotonus (HP:0002179)	2.10339514
53	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.09127020
54	Onion bulb formation (HP:0003383)	2.07219239
55	Follicular hyperkeratosis (HP:0007502)	2.06928572
56	Polycythemia (HP:0001901)	2.06723702
57	Gingival bleeding (HP:0000225)	2.05474018
58	Neonatal respiratory distress (HP:0002643)	2.04593041
59	Facial diplegia (HP:0001349)	2.04277564
60	Elevated erythrocyte sedimentation rate (HP:0003565)	2.04253017
61	Increased cerebral lipofuscin (HP:0011813)	1.99650233
62	Peripheral hypomyelination (HP:0007182)	1.96165942
63	Colitis (HP:0002583)	1.92273672
64	Abnormality of the wing of the ilium (HP:0011867)	1.91788252
65	Enlarged kidneys (HP:0000105)	1.88365773
66	Abnormality of the renal medulla (HP:0100957)	1.88079826
67	Pulmonary embolism (HP:0002204)	1.82799930
68	Dehydration (HP:0001944)	1.82685584
69	Chronic diarrhea (HP:0002028)	1.81785539
70	Ulnar bowing (HP:0003031)	1.81619073
71	Recurrent sinusitis (HP:0011108)	1.80717545
72	Abnormal platelet volume (HP:0011876)	1.80541252
73	Abnormality of macular pigmentation (HP:0008002)	1.79059231
74	Acute hepatic failure (HP:0006554)	1.78752903
75	Asymmetric septal hypertrophy (HP:0001670)	1.77393432
76	Abnormality of binocular vision (HP:0011514)	1.76782137
77	Diplopia (HP:0000651)	1.76782137
78	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.75307833
79	Ileus (HP:0002595)	1.74925428
80	Radial bowing (HP:0002986)	1.74877149
81	Increased mean platelet volume (HP:0011877)	1.74199321
82	Lack of skin elasticity (HP:0100679)	1.73151138
83	Hypoplasia of the odontoid process (HP:0003311)	1.71553537
84	Renal tubular acidosis (HP:0001947)	1.71425710
85	Tubulointerstitial fibrosis (HP:0005576)	1.71351207
86	Stomatitis (HP:0010280)	1.70312814
87	Segmental peripheral demyelination/remyelination (HP:0003481)	1.67314517
88	Congenital stationary night blindness (HP:0007642)	1.66908269
89	Severe visual impairment (HP:0001141)	1.66416542
90	Synostosis involving bones of the feet (HP:0009140)	1.65989209
91	Synostosis involving bones of the lower limbs (HP:0009138)	1.65989209
92	Synostosis of carpal bones (HP:0005048)	1.64680738
93	Inability to walk (HP:0002540)	1.63501235
94	Spastic paraparesis (HP:0002313)	1.63433084
95	Hypoproteinemia (HP:0003075)	1.63200656
96	Hemoptysis (HP:0002105)	1.62889767
97	Hematuria (HP:0000790)	1.62631903
98	Steppage gait (HP:0003376)	1.59244596
99	Nonprogressive disorder (HP:0003680)	1.59147059
100	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.58694573

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	9.66021433
2	STK38L	6.71821530
3	LATS2	6.08170822
4	STK38	2.85907295
5	ACVR1B	2.58223511
6	FRK	2.48843890
7	NLK	2.29483877
8	PRKD3	2.24183498
9	KSR2	2.10225349
10	MAP2K2	2.01092091
11	ZAK	2.01085492
12	STK3	1.98278385
13	BMPR1B	1.90687577
14	PIK3CG	1.62882522
15	TAOK3	1.62855014
16	MELK	1.46963317
17	MAP3K3	1.16025092
18	MAP3K2	1.14569255
19	LMTK2	1.00731374
20	PRKD1	0.99376740
21	IRAK3	0.98224802
22	PRKAA2	0.94956575
23	PDPK1	0.93532072
24	EIF2AK3	0.91964659
25	GRK7	0.91171047
26	PINK1	0.89013130
27	TEC	0.86447476
28	DAPK2	0.81261567
29	KIT	0.81059855
30	ADRBK2	0.77624107
31	ADRBK1	0.75375324
32	TNK2	0.74405945
33	TAOK1	0.67919337
34	RIPK4	0.67571593
35	RAF1	0.67285372
36	MAP2K1	0.66629276
37	GRK5	0.65599933
38	PIM2	0.65488171
39	TGFBR1	0.65144876
40	IRAK4	0.60715385
41	PTK2B	0.60467007
42	CSF1R	0.58141516
43	BTK	0.57862430
44	MAP4K2	0.57321883
45	CSNK1A1L	0.57285449
46	FES	0.56189734
47	TGFBR2	0.52112283
48	CSK	0.49683286
49	ERN1	0.49052151
50	JAK3	0.47136856
51	JAK2	0.44838145
52	STK11	0.43490687
53	NEK9	0.42567423
54	HCK	0.42334511
55	TXK	0.41688725
56	MAP2K3	0.41009651
57	PLK2	0.40973552
58	PRKG2	0.40081398
59	ITK	0.38974053
60	MAP4K1	0.38792423
61	TYK2	0.38031911
62	MATK	0.37860817
63	MAPKAPK3	0.37667915
64	SYK	0.36190209
65	MOS	0.34571706
66	GRK6	0.33910173
67	FGR	0.33468319
68	PAK3	0.33437753
69	PAK6	0.33327546
70	MAPK13	0.31226494
71	IKBKB	0.30325863
72	LYN	0.29088086
73	NEK2	0.28612537
74	ABL1	0.27935585
75	NME1	0.27752497
76	MAP3K1	0.27719522
77	GRK1	0.27258042
78	PRKCE	0.26337323
79	PIM1	0.25259294
80	KSR1	0.24759267
81	IRAK1	0.24065867
82	STK24	0.24040427
83	BLK	0.23371706
84	BMX	0.22237999
85	MAPK3	0.21884625
86	ARAF	0.21206370
87	TAOK2	0.18049741
88	BCKDK	0.16969006
89	FER	0.16620537
90	PRKACA	0.16454529
91	PRKACG	0.16153790
92	RET	0.14930993
93	IKBKE	0.14874208
94	NTRK3	0.12519406
95	CSNK1D	0.12419993
96	ZAP70	0.12112458
97	PRKCI	0.09257713
98	LCK	0.09075777
99	TAF1	0.08074461
100	FLT3	0.07465974

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	6.34760047
2	Phototransduction_Homo sapiens_hsa04744	3.90336435
3	Sphingolipid metabolism_Homo sapiens_hsa00600	3.57436853
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.52831265
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.26331810
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.92838330
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.33524163
8	Nicotine addiction_Homo sapiens_hsa05033	2.28836408
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.97010612
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.85046621
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.79105445
12	Taste transduction_Homo sapiens_hsa04742	1.75446975
13	Morphine addiction_Homo sapiens_hsa05032	1.65295661
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.56060114
15	Histidine metabolism_Homo sapiens_hsa00340	1.54185372
16	Platelet activation_Homo sapiens_hsa04611	1.41433226
17	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.39986648
18	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.39645102
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.35392352
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.35046067
21	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.31467872
22	One carbon pool by folate_Homo sapiens_hsa00670	1.31234025
23	Glycerolipid metabolism_Homo sapiens_hsa00561	1.15760858
24	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.12952077
25	Viral myocarditis_Homo sapiens_hsa05416	1.12228907
26	African trypanosomiasis_Homo sapiens_hsa05143	1.12072656
27	Calcium signaling pathway_Homo sapiens_hsa04020	1.11562999
28	GABAergic synapse_Homo sapiens_hsa04727	1.11086350
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.10076039
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.08494108
31	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.07400963
32	ABC transporters_Homo sapiens_hsa02010	1.06614367
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05445740
34	ECM-receptor interaction_Homo sapiens_hsa04512	1.05292910
35	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.01967538
36	VEGF signaling pathway_Homo sapiens_hsa04370	1.01308805
37	Tuberculosis_Homo sapiens_hsa05152	1.00300419
38	Serotonergic synapse_Homo sapiens_hsa04726	0.98006543
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94038882
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91065819
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88242853
42	Glutamatergic synapse_Homo sapiens_hsa04724	0.86871557
43	Glutathione metabolism_Homo sapiens_hsa00480	0.85265773
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.84234822
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81904854
46	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.79459950
47	Olfactory transduction_Homo sapiens_hsa04740	0.75907433
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74837749
49	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.71835788
50	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.71792431
51	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.68584083
52	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.68494452
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66663806
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66599845
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64988221
56	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.64953416
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58206453
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.57041369
59	Bile secretion_Homo sapiens_hsa04976	0.56634606
60	Complement and coagulation cascades_Homo sapiens_hsa04610	0.56115031
61	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.55817914
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55435971
63	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.55306219
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54471765
65	Malaria_Homo sapiens_hsa05144	0.53754318
66	Tyrosine metabolism_Homo sapiens_hsa00350	0.51048399
67	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.50987848
68	Butanoate metabolism_Homo sapiens_hsa00650	0.50913694
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49456322
70	Propanoate metabolism_Homo sapiens_hsa00640	0.45740480
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.44887182
72	Chemokine signaling pathway_Homo sapiens_hsa04062	0.44548138
73	Sulfur metabolism_Homo sapiens_hsa00920	0.42853694
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.42091421
75	Primary immunodeficiency_Homo sapiens_hsa05340	0.40080396
76	Pancreatic cancer_Homo sapiens_hsa05212	0.39636098
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.38964140
78	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.38918576
79	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.34405899
80	Osteoclast differentiation_Homo sapiens_hsa04380	0.33573452
81	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.32914316
82	Peroxisome_Homo sapiens_hsa04146	0.32603050
83	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.32529846
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32174479
85	Circadian entrainment_Homo sapiens_hsa04713	0.31156368
86	Fatty acid elongation_Homo sapiens_hsa00062	0.31151146
87	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.30997196
88	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.30414019
89	Mineral absorption_Homo sapiens_hsa04978	0.30043184
90	Lysosome_Homo sapiens_hsa04142	0.29914459
91	Fatty acid degradation_Homo sapiens_hsa00071	0.29819382
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.28565060
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.26257513
94	Graft-versus-host disease_Homo sapiens_hsa05332	0.25630742
95	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.25474900
96	Colorectal cancer_Homo sapiens_hsa05210	0.25213378
97	Gap junction_Homo sapiens_hsa04540	0.25085344
98	Allograft rejection_Homo sapiens_hsa05330	0.24275485
99	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.22938935
100	Leishmaniasis_Homo sapiens_hsa05140	0.21527287

SDHDP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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