SDK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)4.37250313
2cilium movement (GO:0003341)3.98339703
3embryonic retina morphogenesis in camera-type eye (GO:0060059)3.91998639
4auditory receptor cell differentiation (GO:0042491)3.87986456
5cilium or flagellum-dependent cell motility (GO:0001539)3.81771382
6apical protein localization (GO:0045176)3.58062875
7sequestering of extracellular ligand from receptor (GO:0035581)3.49659631
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.48453557
9neuron projection extension involved in neuron projection guidance (GO:1902284)3.38376526
10axon extension involved in axon guidance (GO:0048846)3.38376526
11pyrimidine nucleobase catabolic process (GO:0006208)3.37873804
12endocardial cushion morphogenesis (GO:0003203)3.27629689
13mesenchyme morphogenesis (GO:0072132)3.24515404
14bone trabecula formation (GO:0060346)3.16787612
15epithelial cilium movement (GO:0003351)3.16097000
16axonal fasciculation (GO:0007413)3.07920596
17planar cell polarity pathway involved in neural tube closure (GO:0090179)3.07886149
18metanephric mesenchyme development (GO:0072075)3.04828123
19motile cilium assembly (GO:0044458)3.02593331
20innervation (GO:0060384)2.98219416
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94738430
22presynaptic membrane assembly (GO:0097105)2.93682906
23asymmetric protein localization (GO:0008105)2.91268776
24postsynaptic membrane organization (GO:0001941)2.91223743
25response to pheromone (GO:0019236)2.90617173
26left/right pattern formation (GO:0060972)2.89704776
27inner ear receptor cell differentiation (GO:0060113)2.84133435
28presynaptic membrane organization (GO:0097090)2.83605707
29establishment of monopolar cell polarity (GO:0061162)2.82903863
30establishment or maintenance of monopolar cell polarity (GO:0061339)2.82903863
31layer formation in cerebral cortex (GO:0021819)2.82735087
32regulation of cardioblast proliferation (GO:0003264)2.82401124
33regulation of secondary heart field cardioblast proliferation (GO:0003266)2.82401124
34ear development (GO:0043583)2.79970014
35lung epithelium development (GO:0060428)2.79965419
36establishment of apical/basal cell polarity (GO:0035089)2.79385407
37aorta morphogenesis (GO:0035909)2.79107919
38limb development (GO:0060173)2.78564559
39appendage development (GO:0048736)2.78564559
40collagen fibril organization (GO:0030199)2.76631506
41regulation of axon extension involved in axon guidance (GO:0048841)2.76194535
42endothelial cell chemotaxis (GO:0035767)2.74247728
43establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.74058694
44axon extension (GO:0048675)2.72814403
45establishment or maintenance of apical/basal cell polarity (GO:0035088)2.72729958
46establishment or maintenance of bipolar cell polarity (GO:0061245)2.72729958
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.72524351
48cardiac muscle cell proliferation (GO:0060038)2.72297826
49nucleobase catabolic process (GO:0046113)2.72232170
50synaptic vesicle docking involved in exocytosis (GO:0016081)2.72000992
51negative regulation of catenin import into nucleus (GO:0035414)2.71909360
52membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.71268358
53insulin-like growth factor receptor signaling pathway (GO:0048009)2.70888081
54sensory perception of smell (GO:0007608)2.70072236
55kidney mesenchyme development (GO:0072074)2.69851752
56hair cell differentiation (GO:0035315)2.67919094
57neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.67405765
58outer ear morphogenesis (GO:0042473)2.66691194
59dorsal/ventral axis specification (GO:0009950)2.66642135
60neuron recognition (GO:0008038)2.66136854
61central nervous system projection neuron axonogenesis (GO:0021952)2.65074782
62hippo signaling (GO:0035329)2.65025074
63positive regulation of hormone biosynthetic process (GO:0046886)2.64535285
64regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.63018818
65membrane repolarization during action potential (GO:0086011)2.62851505
66regulation of somitogenesis (GO:0014807)2.61619344
67embryonic body morphogenesis (GO:0010172)2.61331327
68mechanoreceptor differentiation (GO:0042490)2.61045792
69regulation of axon guidance (GO:1902667)2.60605790
70dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.59802387
71positive regulation of smoothened signaling pathway (GO:0045880)2.57561816
72ventricular system development (GO:0021591)2.56985615
73negative regulation of axon extension involved in axon guidance (GO:0048843)2.55189872
74myoblast fusion (GO:0007520)2.54990537
75epithelial cell fate commitment (GO:0072148)2.54956248
76ionotropic glutamate receptor signaling pathway (GO:0035235)2.54515537
77heart morphogenesis (GO:0003007)2.52786111
78urinary tract smooth muscle contraction (GO:0014848)2.52604997
79neuron cell-cell adhesion (GO:0007158)2.52241863
80lateral sprouting from an epithelium (GO:0060601)2.51217195
81establishment of nucleus localization (GO:0040023)2.50680423
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.49794253
83ganglion development (GO:0061548)2.49493333
84regulation of non-canonical Wnt signaling pathway (GO:2000050)2.48739333
85axoneme assembly (GO:0035082)2.47972694
86mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.46725129
87cranial nerve morphogenesis (GO:0021602)2.46169895
88collecting duct development (GO:0072044)2.43652279
89cytoskeletal anchoring at plasma membrane (GO:0007016)2.41213056
90locomotory exploration behavior (GO:0035641)2.40647206
91body morphogenesis (GO:0010171)2.40540508
92nonmotile primary cilium assembly (GO:0035058)2.39203333
93regulation of short-term neuronal synaptic plasticity (GO:0048172)2.38942951
94positive regulation of gastrulation (GO:2000543)2.38150273
95dendritic spine morphogenesis (GO:0060997)2.37233437
96collagen catabolic process (GO:0030574)2.37182047
97suckling behavior (GO:0001967)2.36782971
98metanephric tubule development (GO:0072170)2.36672944
99metanephric nephron tubule development (GO:0072234)2.36672944
100spinal cord development (GO:0021510)2.36644884
101cell migration in hindbrain (GO:0021535)2.36491112
102neuronal ion channel clustering (GO:0045161)2.35608065
103collagen metabolic process (GO:0032963)2.35402623
104semaphorin-plexin signaling pathway (GO:0071526)2.35266395
105negative regulation of axon guidance (GO:1902668)2.34917205
106regulation of neuron migration (GO:2001222)2.34219137
107head development (GO:0060322)2.33770997
108convergent extension (GO:0060026)2.33192588
109synapse assembly (GO:0007416)2.33145077
110establishment of planar polarity (GO:0001736)2.31307758
111establishment of tissue polarity (GO:0007164)2.31307758
112calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.31104852
113gastrulation with mouth forming second (GO:0001702)2.30001958
114cardiac myofibril assembly (GO:0055003)2.29443523
115negative regulation of fatty acid transport (GO:2000192)2.29410743
116mesenchymal to epithelial transition (GO:0060231)2.29251350
117retinal ganglion cell axon guidance (GO:0031290)2.28827995
118extracellular negative regulation of signal transduction (GO:1900116)2.28257702
119extracellular regulation of signal transduction (GO:1900115)2.28257702
120negative regulation of embryonic development (GO:0045992)2.27877183
121camera-type eye morphogenesis (GO:0048593)2.27750387
122regulation of transforming growth factor beta2 production (GO:0032909)2.27493167
123negative chemotaxis (GO:0050919)2.26768918
124kidney morphogenesis (GO:0060993)2.26624556
125protein heterotrimerization (GO:0070208)2.26420699
126mesenchymal-epithelial cell signaling (GO:0060638)2.25981982
127cell-cell junction maintenance (GO:0045217)2.25876909
128developmental cell growth (GO:0048588)2.25645142
129pharyngeal system development (GO:0060037)2.25639291
130multicellular organismal macromolecule metabolic process (GO:0044259)2.25251552
131microtubule bundle formation (GO:0001578)2.24437840
132neuron projection extension (GO:1990138)2.24271360
133central nervous system neuron axonogenesis (GO:0021955)2.23959584
134non-canonical Wnt signaling pathway (GO:0035567)2.23833120
135cilium assembly (GO:0042384)2.23534756
136regulation of skeletal muscle cell differentiation (GO:2001014)2.23530824
137neuronal stem cell maintenance (GO:0097150)2.23521469
138eye morphogenesis (GO:0048592)2.23442678
139astrocyte differentiation (GO:0048708)2.22172203
140cranial nerve development (GO:0021545)2.22170263
141G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.22119190
142cerebral cortex radially oriented cell migration (GO:0021799)2.21819741
143skeletal muscle organ development (GO:0060538)2.21443758
144dendrite morphogenesis (GO:0048813)2.21348424
145cilium organization (GO:0044782)2.20077033
146morphogenesis of an epithelial sheet (GO:0002011)2.19850518
147embryonic foregut morphogenesis (GO:0048617)2.18436170
148vocalization behavior (GO:0071625)2.18125554
149mating behavior (GO:0007617)2.18107340
150intraciliary transport (GO:0042073)2.17766871
151regulation of smoothened signaling pathway (GO:0008589)2.17588306
152renal system development (GO:0072001)2.17066128
153Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.16854870
154middle ear morphogenesis (GO:0042474)2.16272487
155striated muscle cell proliferation (GO:0014855)2.16143308
156negative regulation of cytosolic calcium ion concentration (GO:0051481)2.15750283
157polarized epithelial cell differentiation (GO:0030859)2.14896199
158multicellular organismal catabolic process (GO:0044243)2.14453253
159cochlea development (GO:0090102)2.13566588
160paraxial mesoderm development (GO:0048339)2.13389316
161cell proliferation involved in metanephros development (GO:0072203)2.12917763
162regulation of establishment of planar polarity (GO:0090175)2.12809792
163type B pancreatic cell development (GO:0003323)2.10518701
164multicellular organismal metabolic process (GO:0044236)2.10120567
165detection of calcium ion (GO:0005513)2.10082793
166cochlea morphogenesis (GO:0090103)2.09341913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.70349279
2JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61251550
3RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59387920
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59387920
5GBX2_23144817_ChIP-Seq_PC3_Human2.56781832
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48768667
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.45182761
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.40658383
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32554539
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29209915
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27808695
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22168943
13RNF2_27304074_Chip-Seq_ESCs_Mouse2.21849984
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13401891
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.13185223
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10837400
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10776679
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06324427
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00312148
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.99691983
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99214778
22* DROSHA_22980978_ChIP-Seq_HELA_Human1.92896982
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88190941
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83487465
25* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76376081
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74889087
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73189699
28* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72369904
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72218946
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66886634
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.61954588
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59098299
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57772035
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.57104680
35AHR_22903824_ChIP-Seq_MCF-7_Human1.55816802
36* RING1B_27294783_Chip-Seq_ESCs_Mouse1.51486914
37ISL1_27105846_Chip-Seq_CPCs_Mouse1.49487297
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48297194
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.46563657
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.46313092
41SMAD4_21799915_ChIP-Seq_A2780_Human1.46189326
42* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.45807184
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.44711343
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43830622
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41455267
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.40059097
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.36985200
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36410450
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34165470
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29173084
51* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27864447
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26812687
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25551333
54* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24529167
55* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24455110
56REST_21632747_ChIP-Seq_MESCs_Mouse1.24164854
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23926098
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22642244
59* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21584841
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21438881
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.21145049
62* AR_19668381_ChIP-Seq_PC3_Human1.21050171
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.19116045
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18799197
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18384465
66* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17872859
67* SMAD3_21741376_ChIP-Seq_EPCs_Human1.17678234
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16855337
69* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16149436
70* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16149436
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15537836
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14962173
73KDM2B_26808549_Chip-Seq_K562_Human1.14044328
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13700926
75TAF15_26573619_Chip-Seq_HEK293_Human1.11805552
76* SMAD3_21741376_ChIP-Seq_ESCs_Human1.11643760
77* STAT3_23295773_ChIP-Seq_U87_Human1.11316262
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10935626
79* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10299432
80TP53_18474530_ChIP-ChIP_U2OS_Human1.09623439
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08837759
82ZNF274_21170338_ChIP-Seq_K562_Hela1.08756980
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.05981352
84RNF2_27304074_Chip-Seq_NSC_Mouse1.05561344
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05266806
86* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01643498
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01155967
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00826083
89P300_19829295_ChIP-Seq_ESCs_Human1.00584037
90AR_21572438_ChIP-Seq_LNCaP_Human1.00055670
91* TCF4_23295773_ChIP-Seq_U87_Human0.99025763
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.98942009
93* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98430517
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98299055
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97750638
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97325761
97CTCF_27219007_Chip-Seq_Bcells_Human0.96951428
98* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96865685
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96455644
100* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95339159
101* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95204980
102* RUNX2_22187159_ChIP-Seq_PCA_Human0.94513807
103ESR1_20079471_ChIP-ChIP_T-47D_Human0.94219191
104RARB_27405468_Chip-Seq_BRAIN_Mouse0.93172465
105SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92745757
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91097325
107ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90985027
108IGF1R_20145208_ChIP-Seq_DFB_Human0.90613165
109TP53_16413492_ChIP-PET_HCT116_Human0.90346176
110* AR_25329375_ChIP-Seq_VCAP_Human0.90248684
111ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89028466
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89027203
113* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88914730
114* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88670420
115* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87976479
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.87976172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell3.15036227
2MP0005377_hearing/vestibular/ear_phenot2.91513148
3MP0003878_abnormal_ear_physiology2.91513148
4MP0008438_abnormal_cutaneous_collagen2.75463063
5MP0003122_maternal_imprinting2.70235320
6MP0002822_catalepsy2.61516814
7MP0002909_abnormal_adrenal_gland2.44702990
8MP0001485_abnormal_pinna_reflex2.44568828
9MP0005623_abnormal_meninges_morphology2.41672666
10MP0004272_abnormal_basement_membrane2.26761473
11MP0003941_abnormal_skin_development2.26505624
12MP0000534_abnormal_ureter_morphology2.15405813
13MP0003942_abnormal_urinary_system2.13132188
14MP0001984_abnormal_olfaction2.07052179
15MP0005503_abnormal_tendon_morphology1.92785316
16MP0008789_abnormal_olfactory_epithelium1.87910057
17MP0004145_abnormal_muscle_electrophysio1.86672384
18MP0000026_abnormal_inner_ear1.80757650
19MP0000049_abnormal_middle_ear1.69651753
20MP0003283_abnormal_digestive_organ1.67858295
21MP0002249_abnormal_larynx_morphology1.61952652
22MP0005499_abnormal_olfactory_system1.60313487
23MP0005394_taste/olfaction_phenotype1.60313487
24MP0005248_abnormal_Harderian_gland1.59771508
25MP0001299_abnormal_eye_distance/1.59428574
26MP0002938_white_spotting1.59348454
27MP0005257_abnormal_intraocular_pressure1.59186188
28MP0009780_abnormal_chondrocyte_physiolo1.55199267
29MP0010030_abnormal_orbit_morphology1.53708074
30MP0005275_abnormal_skin_tensile1.53389147
31MP0002184_abnormal_innervation1.51654699
32MP0003385_abnormal_body_wall1.49814787
33MP0001963_abnormal_hearing_physiology1.49040620
34MP0009250_abnormal_appendicular_skeleto1.48434536
35MP0000569_abnormal_digit_pigmentation1.46338333
36MP0003121_genomic_imprinting1.42734102
37MP0005508_abnormal_skeleton_morphology1.39520614
38MP0003787_abnormal_imprinting1.39205021
39MP0000428_abnormal_craniofacial_morphol1.38540893
40MP0005409_darkened_coat_color1.38076618
41MP0000566_synostosis1.37995314
42MP0002233_abnormal_nose_morphology1.37155847
43MP0004133_heterotaxia1.35929515
44MP0002638_abnormal_pupillary_reflex1.32370958
45MP0004858_abnormal_nervous_system1.31009317
46MP0006276_abnormal_autonomic_nervous1.29933456
47MP0009053_abnormal_anal_canal1.29767853
48MP0001486_abnormal_startle_reflex1.27909125
49MP0002116_abnormal_craniofacial_bone1.27687097
50MP0000778_abnormal_nervous_system1.25298589
51MP0002932_abnormal_joint_morphology1.24176044
52MP0003115_abnormal_respiratory_system1.23363880
53MP0003935_abnormal_craniofacial_develop1.22747912
54MP0004885_abnormal_endolymph1.22518486
55MP0003755_abnormal_palate_morphology1.22325769
56MP0004134_abnormal_chest_morphology1.21750842
57MP0002734_abnormal_mechanical_nocicepti1.17229640
58MP0001502_abnormal_circadian_rhythm1.16957231
59MP0005367_renal/urinary_system_phenotyp1.15950037
60MP0000516_abnormal_urinary_system1.15950037
61MP0002152_abnormal_brain_morphology1.14173625
62MP0004859_abnormal_synaptic_plasticity1.13607180
63MP0005645_abnormal_hypothalamus_physiol1.12856142
64MP0005187_abnormal_penis_morphology1.12298955
65MP0002063_abnormal_learning/memory/cond1.11149298
66MP0000579_abnormal_nail_morphology1.08943114
67MP0003937_abnormal_limbs/digits/tail_de1.08680964
68MP0002572_abnormal_emotion/affect_behav1.08460574
69MP0009384_cardiac_valve_regurgitation1.04974887
70MP0000762_abnormal_tongue_morphology1.04145656
71MP0005423_abnormal_somatic_nervous1.04125006
72MP0002896_abnormal_bone_mineralization1.03619487
73MP0000383_abnormal_hair_follicle1.03549791
74MP0000537_abnormal_urethra_morphology1.03228347
75MP0002108_abnormal_muscle_morphology1.00953716
76MP0003045_fibrosis1.00903866
77MP0003123_paternal_imprinting1.00568599
78MP0000678_abnormal_parathyroid_gland1.00338014
79MP0006072_abnormal_retinal_apoptosis1.00046160
80MP0004270_analgesia0.97674375
81MP0003634_abnormal_glial_cell0.97653118
82MP0002752_abnormal_somatic_nervous0.96890849
83MP0002109_abnormal_limb_morphology0.96069448
84MP0002697_abnormal_eye_size0.95349160
85MP0002653_abnormal_ependyma_morphology0.95070142
86MP0001346_abnormal_lacrimal_gland0.94754696
87MP0001958_emphysema0.94118357
88MP0002092_abnormal_eye_morphology0.92962672
89MP0003705_abnormal_hypodermis_morpholog0.92895749
90MP0002882_abnormal_neuron_morphology0.91679030
91MP0000631_abnormal_neuroendocrine_gland0.91253635
92MP0003635_abnormal_synaptic_transmissio0.89798815
93MP0002735_abnormal_chemical_nociception0.88711950
94MP0000751_myopathy0.88399449
95MP0004742_abnormal_vestibular_system0.88073736
96MP0010678_abnormal_skin_adnexa0.87912542
97MP0003938_abnormal_ear_development0.87903652
98MP0001270_distended_abdomen0.87868233
99MP0002177_abnormal_outer_ear0.86351158
100MP0003119_abnormal_digestive_system0.86342338
101MP0003861_abnormal_nervous_system0.86335628
102MP0005076_abnormal_cell_differentiation0.85434308
103MP0002081_perinatal_lethality0.85256297
104MP0001970_abnormal_pain_threshold0.85147124
105MP0002736_abnormal_nociception_after0.85083503
106MP0005171_absent_coat_pigmentation0.84411143
107MP0000163_abnormal_cartilage_morphology0.84349030
108MP0000462_abnormal_digestive_system0.83960574
109MP0001944_abnormal_pancreas_morphology0.83671384
110MP0001293_anophthalmia0.83474141
111MP0005646_abnormal_pituitary_gland0.83001372
112MP0004811_abnormal_neuron_physiology0.82978623
113MP0002751_abnormal_autonomic_nervous0.82845260
114MP0004084_abnormal_cardiac_muscle0.82442146
115MP0002234_abnormal_pharynx_morphology0.81548057
116MP0000432_abnormal_head_morphology0.80725978
117MP0010386_abnormal_urinary_bladder0.80122141
118MP0003890_abnormal_embryonic-extraembry0.79881238
119MP0002115_abnormal_skeleton_extremities0.79538673
120MP0001849_ear_inflammation0.78908476
121MP0001286_abnormal_eye_development0.78736810
122MP0001188_hyperpigmentation0.77480454
123MP0002733_abnormal_thermal_nociception0.76870716
124MP0002067_abnormal_sensory_capabilities0.76642154
125MP0002089_abnormal_postnatal_growth/wei0.76237359
126MP0002557_abnormal_social/conspecific_i0.76114644
127MP0000955_abnormal_spinal_cord0.75442834
128MP0000733_abnormal_muscle_development0.75208205
129MP0010368_abnormal_lymphatic_system0.74439444
130MP0002272_abnormal_nervous_system0.74435430

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.15383796
2Abnormal ciliary motility (HP:0012262)3.82002354
3Abnormal respiratory motile cilium physiology (HP:0012261)3.75704821
4Abnormal respiratory epithelium morphology (HP:0012253)3.60399992
5Abnormal respiratory motile cilium morphology (HP:0005938)3.60399992
6Rhinitis (HP:0012384)3.43749452
7Renal duplication (HP:0000075)3.16892747
8Vertebral arch anomaly (HP:0008438)3.11616532
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.11181537
10Absent/shortened dynein arms (HP:0200106)3.11181537
11Cerebral aneurysm (HP:0004944)3.00200677
12Ulnar claw (HP:0001178)2.98210500
13Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.97633055
14Premature rupture of membranes (HP:0001788)2.92476846
15Protrusio acetabuli (HP:0003179)2.88921970
16Bladder diverticulum (HP:0000015)2.87911079
17Aortic dissection (HP:0002647)2.86745912
18Arterial tortuosity (HP:0005116)2.80039542
19Renovascular hypertension (HP:0100817)2.77247339
20Neonatal short-limb short stature (HP:0008921)2.76640457
21Morphological abnormality of the middle ear (HP:0008609)2.67705873
22Vascular tortuosity (HP:0004948)2.59281432
23Shallow orbits (HP:0000586)2.56874859
24Ankle contracture (HP:0006466)2.56617506
25Abnormality of the aortic arch (HP:0012303)2.55416666
26Cutaneous finger syndactyly (HP:0010554)2.53318769
27Hypoplastic ischia (HP:0003175)2.53198823
28Genetic anticipation (HP:0003743)2.52719940
29Short 4th metacarpal (HP:0010044)2.50015571
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50015571
31Lip pit (HP:0100267)2.48747478
32Epiphyseal dysplasia (HP:0002656)2.45796359
33Midline defect of the nose (HP:0004122)2.43919549
34Hyperacusis (HP:0010780)2.43359133
35Bell-shaped thorax (HP:0001591)2.37432889
36Abnormality of the pubic bones (HP:0003172)2.36661681
37Chronic bronchitis (HP:0004469)2.36650005
38Broad metatarsal (HP:0001783)2.35280461
39Elfin facies (HP:0004428)2.32757997
40Abnormality of dentin (HP:0010299)2.32404541
41Bowel diverticulosis (HP:0005222)2.29326888
42Aortic aneurysm (HP:0004942)2.25557502
43Hepatoblastoma (HP:0002884)2.23867301
44Vitreoretinal degeneration (HP:0000655)2.22673192
45Abnormality of the ischium (HP:0003174)2.19939367
46Bifid tongue (HP:0010297)2.19869314
47Hypoventilation (HP:0002791)2.19301011
48Wide anterior fontanel (HP:0000260)2.18844062
49Atrophic scars (HP:0001075)2.17197514
50Ulnar bowing (HP:0003031)2.16807279
51Flat cornea (HP:0007720)2.16683213
52Cutaneous syndactyly (HP:0012725)2.15547228
53Soft skin (HP:0000977)2.14608995
54Insomnia (HP:0100785)2.13891713
55Absent frontal sinuses (HP:0002688)2.12490213
56Turricephaly (HP:0000262)2.11755493
57Fragile skin (HP:0001030)2.10596776
58Action tremor (HP:0002345)2.09699647
59Termporal pattern (HP:0011008)2.06283195
60Insidious onset (HP:0003587)2.06283195
61Wrist flexion contracture (HP:0001239)2.03926735
62Mixed hearing impairment (HP:0000410)2.00802563
63Absent eyebrow (HP:0002223)2.00792558
64Abnormality of the 4th metacarpal (HP:0010012)2.00355654
65Severe Myopia (HP:0011003)2.00212191
66Mitral valve prolapse (HP:0001634)1.97589057
67Atelectasis (HP:0100750)1.95740654
68Bronchomalacia (HP:0002780)1.93159002
69Hypoplastic labia majora (HP:0000059)1.92443821
70Mesomelia (HP:0003027)1.91607746
71Overriding aorta (HP:0002623)1.91331476
72Preauricular pit (HP:0004467)1.91251925
73Periauricular skin pits (HP:0100277)1.91251925
74Bronchiectasis (HP:0002110)1.91151098
75Humeroradial synostosis (HP:0003041)1.89956610
76Synostosis involving the elbow (HP:0003938)1.89956610
77Follicular hyperkeratosis (HP:0007502)1.88581139
78Skin pits (HP:0100276)1.87755902
79Type 1 muscle fiber predominance (HP:0003803)1.87331073
80Dilatation of the ascending aorta (HP:0005111)1.87263158
81Truncal obesity (HP:0001956)1.87035612
82Bilateral microphthalmos (HP:0007633)1.86756165
83Asymmetry of the thorax (HP:0001555)1.86507303
84Subacute progressive viral hepatitis (HP:0006572)1.85494234
85Abnormality of the labia majora (HP:0012881)1.84348366
86Enlarged penis (HP:0000040)1.83023703
87Absent eyelashes (HP:0000561)1.82396630
88Narrow nasal bridge (HP:0000446)1.81771378
89Buphthalmos (HP:0000557)1.80945605
90Occipital encephalocele (HP:0002085)1.80394290
91Overgrowth (HP:0001548)1.78860938
92Aplasia involving bones of the upper limbs (HP:0009823)1.77729239
93Aplasia of the phalanges of the hand (HP:0009802)1.77729239
94Aplasia involving bones of the extremities (HP:0009825)1.77729239
95Omphalocele (HP:0001539)1.77546949
96Papillary thyroid carcinoma (HP:0002895)1.74754960
97Abnormality of the diencephalon (HP:0010662)1.73241680
98Segmental peripheral demyelination/remyelination (HP:0003481)1.72286290
99Abnormality of the phalanges of the hallux (HP:0010057)1.72281739
100Labial hypoplasia (HP:0000066)1.72266181
101Myelomeningocele (HP:0002475)1.71249990
102Precocious puberty (HP:0000826)1.70871504
103Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69578262
104Macroorchidism (HP:0000053)1.69429647
105Mild short stature (HP:0003502)1.68253372
106Deviation of the hallux (HP:0010051)1.65539303
107Bicornuate uterus (HP:0000813)1.65009353
108Broad long bones (HP:0005622)1.64520490
109Alacrima (HP:0000522)1.63835894
110Abnormality of midbrain morphology (HP:0002418)1.63718129
111Molar tooth sign on MRI (HP:0002419)1.63718129
112Arnold-Chiari malformation (HP:0002308)1.63496786
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.63395389
114Coronal craniosynostosis (HP:0004440)1.63160156
115Vertebral clefting (HP:0008428)1.62500768
116Tibial bowing (HP:0002982)1.61619610
117Abnormality of the right ventricle (HP:0001707)1.61074077
118Laryngomalacia (HP:0001601)1.59395375
119Infertility (HP:0000789)1.58605402
120Hallux valgus (HP:0001822)1.58552875
121Mildly elevated creatine phosphokinase (HP:0008180)1.58505315
122High anterior hairline (HP:0009890)1.57870504
123Nuclear cataract (HP:0100018)1.57209205
124Aneurysm (HP:0002617)1.57093927
125Double outlet right ventricle (HP:0001719)1.55766653
126Congenital malformation of the right heart (HP:0011723)1.55766653
127Cystic liver disease (HP:0006706)1.55516798
128Prolonged QT interval (HP:0001657)1.54302157
129Syncope (HP:0001279)1.54140581
130Shawl scrotum (HP:0000049)1.54122806
131Hyperextensible skin (HP:0000974)1.52948333
132Abnormality of the nasolacrimal system (HP:0000614)1.52558080
133Germ cell neoplasia (HP:0100728)1.52028495
134Trigonocephaly (HP:0000243)1.51926337
135Exostoses (HP:0100777)1.51722074
136Renal dysplasia (HP:0000110)1.51207233
137Sprengel anomaly (HP:0000912)1.50885089
138Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.50858585
139Renal hypoplasia (HP:0000089)1.50655367
140Hyperkalemia (HP:0002153)1.50350512
141Obstructive sleep apnea (HP:0002870)1.50192011
142Disproportionate tall stature (HP:0001519)1.49366736
143Broad finger (HP:0001500)1.49361656
144Abnormality of the distal phalanx of the thumb (HP:0009617)1.49000982
145Abnormality of the dental root (HP:0006486)1.48427293
146Taurodontia (HP:0000679)1.48427293
147Abnormality of permanent molar morphology (HP:0011071)1.48427293
148Obsessive-compulsive behavior (HP:0000722)1.46001225
149Nephronophthisis (HP:0000090)1.45909869
150Broad phalanx (HP:0006009)1.45702655
151Short nail (HP:0001799)1.44776761
152Bowing of the arm (HP:0006488)1.44459655
153Bowed forearm bones (HP:0003956)1.44459655
154Flat acetabular roof (HP:0003180)1.43466127
155Male infertility (HP:0003251)1.43219343
156Abnormality of molar (HP:0011077)1.41793756
157Abnormality of molar morphology (HP:0011070)1.41793756
158Progressive cerebellar ataxia (HP:0002073)1.41704033
159Genu recurvatum (HP:0002816)1.41687302
160Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.41090400
161True hermaphroditism (HP:0010459)1.40511182
162Tubulointerstitial nephritis (HP:0001970)1.40350306
163Broad thumb (HP:0011304)1.39858573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.23574690
2LATS13.29595352
3TNIK2.93965361
4MAPK152.14099306
5MARK12.05020459
6FER2.00502125
7CAMK1G1.95380041
8MAP3K41.94796589
9LATS21.94440667
10NTRK31.90928001
11ERBB31.89214192
12RIPK11.88332793
13PDGFRA1.82691641
14CDK121.81385592
15EPHB21.78855635
16NTRK11.76104563
17PRKD31.74347544
18PAK31.64633198
19STK38L1.55089325
20FGFR21.50514092
21TRIB31.45140814
22TYRO31.44215010
23NTRK21.43662593
24CDC42BPA1.38983205
25ERBB21.31898108
26MAPK131.28616104
27KSR11.27157801
28ICK1.26861104
29EEF2K1.24253393
30SIK11.20552612
31CSNK1A1L1.20073381
32CAMK1D1.19251852
33PNCK1.19165903
34DMPK1.18702983
35STK31.16621280
36MINK11.15450525
37WNK11.15269088
38RET1.12241178
39STK381.09712384
40MAP2K71.07412834
41PLK21.04327899
42DAPK21.03777596
43MAP3K91.03749560
44PTK21.00761910
45WNK30.99760268
46AKT30.98624844
47MAP3K20.98615743
48PAK60.97925697
49PHKG10.97822512
50PHKG20.97822512
51RPS6KA20.94313923
52INSRR0.92395879
53TGFBR20.91783638
54MARK20.91493749
55CASK0.91323714
56MAP3K70.90941501
57UHMK10.90601476
58EPHA20.90557745
59WNK40.90358983
60NEK20.87696888
61NUAK10.86808727
62EPHA30.83621425
63DYRK1B0.81717508
64PKN20.76577662
65PAK20.75820750
66BCR0.75425204
67TRPM70.75360559
68HIPK20.74645972
69BRD40.74160374
70STK240.73802646
71DYRK20.73373455
72CSNK1G20.73247538
73MTOR0.73148445
74ROCK10.72526354
75FGFR40.72057522
76PTK2B0.71149342
77ROCK20.67159637
78MAP2K40.66790389
79SIK20.66089165
80IRAK20.63606552
81SGK30.63065312
82FGFR10.62895067
83NLK0.62663939
84CDK50.62357023
85PRKCH0.62313726
86MOS0.61422618
87SCYL20.61385220
88MAP3K60.60756563
89MKNK20.60029984
90PTK60.59897430
91MET0.59340215
92FGFR30.59328004
93SGK4940.59130562
94SGK2230.59130562
95PDGFRB0.58108963
96MAP3K100.57603931
97PRKCZ0.57194534
98TAF10.56376218
99PRKCE0.55978233
100OBSCN0.55582470
101ADRBK10.54328899
102PRKCI0.54228046
103CSNK1G10.53978704
104LMTK20.53883911
105CAMKK10.52071989
106CSNK1G30.52022443
107CAMK2D0.50491426
108FRK0.48635500
109SMG10.45979043
110GSK3B0.45841825
111MAP2K20.45500091
112PRKD20.44449547
113CSNK1E0.44035676
114STK110.43564559
115CAMK2A0.43338472
116RPS6KL10.42610768
117RPS6KC10.42610768
118RPS6KB10.42344726
119BMPR1B0.42174880
120PRKCG0.40198490
121MYLK0.39483214
122MAPK100.38491084
123DYRK1A0.38361942
124RPS6KA60.38326256
125SGK10.38113966
126SGK20.37916505
127PRKAA10.36803871
128MAPK80.35542203
129CDK90.34959182
130TAOK10.34348606

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.22842269
2ECM-receptor interaction_Homo sapiens_hsa045122.01119209
3Insulin secretion_Homo sapiens_hsa049111.83191061
4Basal cell carcinoma_Homo sapiens_hsa052171.78569699
5Dilated cardiomyopathy_Homo sapiens_hsa054141.65985905
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.64201884
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.62959521
8Hedgehog signaling pathway_Homo sapiens_hsa043401.62614463
9Protein digestion and absorption_Homo sapiens_hsa049741.61700147
10Synaptic vesicle cycle_Homo sapiens_hsa047211.60868458
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60746898
12Axon guidance_Homo sapiens_hsa043601.60666241
13Hippo signaling pathway_Homo sapiens_hsa043901.58686515
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50453410
15Wnt signaling pathway_Homo sapiens_hsa043101.47442887
16Circadian entrainment_Homo sapiens_hsa047131.45842382
17Melanogenesis_Homo sapiens_hsa049161.43971003
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43285039
19Focal adhesion_Homo sapiens_hsa045101.42421867
20Taste transduction_Homo sapiens_hsa047421.42107696
21Amphetamine addiction_Homo sapiens_hsa050311.39378763
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37588649
23Estrogen signaling pathway_Homo sapiens_hsa049151.35364357
24Dopaminergic synapse_Homo sapiens_hsa047281.34525940
25Glioma_Homo sapiens_hsa052141.33310981
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32811639
27Adherens junction_Homo sapiens_hsa045201.32773610
28Cholinergic synapse_Homo sapiens_hsa047251.32612544
29Dorso-ventral axis formation_Homo sapiens_hsa043201.32500826
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32348473
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29935767
32Type II diabetes mellitus_Homo sapiens_hsa049301.29432497
33GABAergic synapse_Homo sapiens_hsa047271.29077899
34Endometrial cancer_Homo sapiens_hsa052131.28569333
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27718321
36Notch signaling pathway_Homo sapiens_hsa043301.26440716
37GnRH signaling pathway_Homo sapiens_hsa049121.25852751
38ErbB signaling pathway_Homo sapiens_hsa040121.23938383
39Nicotine addiction_Homo sapiens_hsa050331.22781210
40Lysine degradation_Homo sapiens_hsa003101.21780424
41Morphine addiction_Homo sapiens_hsa050321.21525437
42Tight junction_Homo sapiens_hsa045301.18483511
43Cocaine addiction_Homo sapiens_hsa050301.18232114
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17893366
45Glutamatergic synapse_Homo sapiens_hsa047241.13771303
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12130420
47Gap junction_Homo sapiens_hsa045401.12097502
48Proteoglycans in cancer_Homo sapiens_hsa052051.11643895
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10296639
50Colorectal cancer_Homo sapiens_hsa052101.09419693
51TGF-beta signaling pathway_Homo sapiens_hsa043501.07992885
52Long-term potentiation_Homo sapiens_hsa047201.07639706
53Phototransduction_Homo sapiens_hsa047441.06433312
54Oxytocin signaling pathway_Homo sapiens_hsa049211.06422982
55Fatty acid biosynthesis_Homo sapiens_hsa000611.05545588
56Gastric acid secretion_Homo sapiens_hsa049711.05166197
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03354283
58Serotonergic synapse_Homo sapiens_hsa047261.01093938
59Amoebiasis_Homo sapiens_hsa051461.00731382
60Renin secretion_Homo sapiens_hsa049241.00353418
61Salivary secretion_Homo sapiens_hsa049700.99412653
62Melanoma_Homo sapiens_hsa052180.97531595
63Chronic myeloid leukemia_Homo sapiens_hsa052200.95728940
64AMPK signaling pathway_Homo sapiens_hsa041520.94901898
65Vibrio cholerae infection_Homo sapiens_hsa051100.94508504
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93657372
67cAMP signaling pathway_Homo sapiens_hsa040240.92781004
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.92059781
69Long-term depression_Homo sapiens_hsa047300.91542617
70Calcium signaling pathway_Homo sapiens_hsa040200.90632247
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89319766
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.88641857
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88323908
74Pancreatic secretion_Homo sapiens_hsa049720.88126485
75Steroid biosynthesis_Homo sapiens_hsa001000.86124416
76Circadian rhythm_Homo sapiens_hsa047100.85871588
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85304639
78Butanoate metabolism_Homo sapiens_hsa006500.84992408
79Renal cell carcinoma_Homo sapiens_hsa052110.84632471
80Thyroid hormone synthesis_Homo sapiens_hsa049180.84507872
81Pathways in cancer_Homo sapiens_hsa052000.82853938
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82646775
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81345327
84Rap1 signaling pathway_Homo sapiens_hsa040150.80093827
85MicroRNAs in cancer_Homo sapiens_hsa052060.79557805
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79275293
87mTOR signaling pathway_Homo sapiens_hsa041500.79141277
88Prostate cancer_Homo sapiens_hsa052150.78427532
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77483013
90Small cell lung cancer_Homo sapiens_hsa052220.77227627
91Bladder cancer_Homo sapiens_hsa052190.77042236
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76306513
93MAPK signaling pathway_Homo sapiens_hsa040100.74923461
94Prolactin signaling pathway_Homo sapiens_hsa049170.74511030
95ABC transporters_Homo sapiens_hsa020100.73996206
96Cardiac muscle contraction_Homo sapiens_hsa042600.73246453
97Pancreatic cancer_Homo sapiens_hsa052120.72930779
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72323155
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71695970
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71637322
101Ras signaling pathway_Homo sapiens_hsa040140.71220244
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70244286
103Insulin signaling pathway_Homo sapiens_hsa049100.69922925
104Ovarian steroidogenesis_Homo sapiens_hsa049130.68950829
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.66458747
106Collecting duct acid secretion_Homo sapiens_hsa049660.64525746
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64207654
108Prion diseases_Homo sapiens_hsa050200.63518573
109Choline metabolism in cancer_Homo sapiens_hsa052310.62614082
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62373700
111Glucagon signaling pathway_Homo sapiens_hsa049220.62181586
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62038244
113FoxO signaling pathway_Homo sapiens_hsa040680.61705104
114Bile secretion_Homo sapiens_hsa049760.61345753
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.60188583
116beta-Alanine metabolism_Homo sapiens_hsa004100.58018559
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53280457
118Inositol phosphate metabolism_Homo sapiens_hsa005620.52976553
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52762987

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