SDPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.22967706
2protein neddylation (GO:0045116)6.74936904
3neutrophil activation involved in immune response (GO:0002283)6.74371993
4regulation of platelet aggregation (GO:0090330)5.88726507
5low-density lipoprotein particle clearance (GO:0034383)5.86819147
6regulation of platelet activation (GO:0010543)5.66552588
7leukocyte migration involved in inflammatory response (GO:0002523)5.45723176
8platelet aggregation (GO:0070527)5.36962891
9blood coagulation, intrinsic pathway (GO:0007597)5.30135204
10vascular endothelial growth factor signaling pathway (GO:0038084)4.96864404
11angiogenesis involved in wound healing (GO:0060055)4.84664695
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.82003208
13adenosine receptor signaling pathway (GO:0001973)4.80294326
14retina vasculature morphogenesis in camera-type eye (GO:0061299)4.79394070
15regulation of sequestering of triglyceride (GO:0010889)4.69974528
16negative regulation of platelet activation (GO:0010544)4.68377151
17negative regulation of homotypic cell-cell adhesion (GO:0034111)4.64205815
18positive regulation of mast cell activation (GO:0033005)4.46781245
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.39483359
20fatty acid transmembrane transport (GO:1902001)4.38738298
21negative regulation of norepinephrine secretion (GO:0010700)4.37497388
22platelet degranulation (GO:0002576)4.33977063
23lymph vessel development (GO:0001945)4.21229953
24regulation of integrin activation (GO:0033623)4.13252962
25neutrophil activation (GO:0042119)4.12122794
26lymphangiogenesis (GO:0001946)4.02175524
27megakaryocyte development (GO:0035855)3.99724172
28regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.97460117
29glomerular filtration (GO:0003094)3.96323012
30G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.96269488
31lipoxygenase pathway (GO:0019372)3.95522040
32regulation of lipoprotein metabolic process (GO:0050746)3.95519031
33cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.94007205
34positive regulation of receptor recycling (GO:0001921)3.93162020
35negative regulation of thymocyte apoptotic process (GO:0070244)3.92711393
36blood vessel maturation (GO:0001955)3.88733001
37renal filtration (GO:0097205)3.85597236
38surfactant homeostasis (GO:0043129)3.85498310
39negative regulation of protein localization to cell surface (GO:2000009)3.84828741
40white fat cell differentiation (GO:0050872)3.84567411
41negative regulation of heart rate (GO:0010459)3.84176979
42brown fat cell differentiation (GO:0050873)3.78532434
43protein heterotrimerization (GO:0070208)3.74332579
44positive regulation of blood coagulation (GO:0030194)3.74323650
45positive regulation of hemostasis (GO:1900048)3.74323650
46extracellular fibril organization (GO:0043206)3.74296189
47carnitine shuttle (GO:0006853)3.72222037
48homotypic cell-cell adhesion (GO:0034109)3.71538895
49positive regulation of fatty acid oxidation (GO:0046321)3.71213859
50platelet activation (GO:0030168)3.69160261
51plasma membrane repair (GO:0001778)3.68609876
52triglyceride catabolic process (GO:0019433)3.68368629
53positive regulation of fatty acid beta-oxidation (GO:0032000)3.68094536
54low-density lipoprotein particle remodeling (GO:0034374)3.67631838
55platelet formation (GO:0030220)3.66889043
56purinergic nucleotide receptor signaling pathway (GO:0035590)3.64859342
57regulation of endothelial cell differentiation (GO:0045601)3.63610531
58positive regulation of macrophage differentiation (GO:0045651)3.61382650
59regulation of homotypic cell-cell adhesion (GO:0034110)3.59865851
60regulation of macrophage derived foam cell differentiation (GO:0010743)3.58522880
61ovulation from ovarian follicle (GO:0001542)3.58341487
62granulocyte activation (GO:0036230)3.56783685
63regulation of Golgi to plasma membrane protein transport (GO:0042996)3.54315482
64negative regulation of appetite (GO:0032099)3.53742000
65negative regulation of response to food (GO:0032096)3.53742000
66negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.50758288
67cell migration involved in sprouting angiogenesis (GO:0002042)3.50584590
68regulation of cholesterol storage (GO:0010885)3.48964825
69endothelial cell morphogenesis (GO:0001886)3.46999091
70regulation of tight junction assembly (GO:2000810)3.46123038
71negative regulation of neural precursor cell proliferation (GO:2000178)3.45366037
72lipid particle organization (GO:0034389)3.45362165
73apoptotic cell clearance (GO:0043277)3.44083617
74positive regulation of systemic arterial blood pressure (GO:0003084)3.42914920
75positive regulation of Rho protein signal transduction (GO:0035025)3.41513496
76valine metabolic process (GO:0006573)3.40583057
77axon extension involved in axon guidance (GO:0048846)3.39228513
78neuron projection extension involved in neuron projection guidance (GO:1902284)3.39228513
79negative regulation of T-helper cell differentiation (GO:0045623)3.36897902
80negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.36897902
81positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.35262718
82basement membrane organization (GO:0071711)3.34522794
83positive regulation of coagulation (GO:0050820)3.34044972
84fatty acid beta-oxidation (GO:0006635)3.29897297
85regulation of MHC class II biosynthetic process (GO:0045346)3.29090553
86regulation of fatty acid oxidation (GO:0046320)3.26886884
87acylglycerol catabolic process (GO:0046464)3.25501024
88neutral lipid catabolic process (GO:0046461)3.25501024
89positive regulation of cAMP-mediated signaling (GO:0043950)3.25470943
90fibril organization (GO:0097435)3.24148211
91morphogenesis of an endothelium (GO:0003159)3.23311933
92endothelial tube morphogenesis (GO:0061154)3.23311933
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21324516
94regulation of vasculogenesis (GO:2001212)3.15495265
95fusion of sperm to egg plasma membrane (GO:0007342)3.13964594
96biotin metabolic process (GO:0006768)3.12802618
97purinergic receptor signaling pathway (GO:0035587)3.12319391
98cardiac myofibril assembly (GO:0055003)3.11964045
99blood vessel endothelial cell migration (GO:0043534)3.11272732
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10745339
101negative regulation of T cell apoptotic process (GO:0070233)3.08868784
102negative regulation of stress fiber assembly (GO:0051497)3.08292648
103regulation of regulatory T cell differentiation (GO:0045589)3.08164242
104chondrocyte proliferation (GO:0035988)3.08039644
105heart trabecula formation (GO:0060347)3.06813967
106negative regulation of heart contraction (GO:0045822)3.05972791
107autophagic vacuole fusion (GO:0000046)3.05798017
108G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.05680756
109vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.03040090
110regulation of mast cell activation (GO:0033003)3.02571909
111regulation of hemostasis (GO:1900046)3.02407917
112regulation of blood coagulation (GO:0030193)3.02407917
113cell adhesion mediated by integrin (GO:0033627)3.00773864
114polyamine biosynthetic process (GO:0006596)3.00160069
115peptide catabolic process (GO:0043171)2.99655653
116membrane raft organization (GO:0031579)2.99589589
117phagocytosis, recognition (GO:0006910)2.98871992
118regulation of memory T cell differentiation (GO:0043380)2.97926649
119beta-amyloid metabolic process (GO:0050435)2.96769498
120collagen fibril organization (GO:0030199)2.94536908
121positive regulation of macrophage cytokine production (GO:0060907)2.93697463
122regulation of receptor recycling (GO:0001919)2.90718795
123sarcomere organization (GO:0045214)2.89854252
124positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.89144551
125regulation of fatty acid beta-oxidation (GO:0031998)2.88795812
126leukocyte degranulation (GO:0043299)2.88585138
127termination of G-protein coupled receptor signaling pathway (GO:0038032)2.88330793
128negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.87275523
129sequestering of extracellular ligand from receptor (GO:0035581)2.86211020
130venous blood vessel morphogenesis (GO:0048845)2.86154617
131fatty acid oxidation (GO:0019395)2.85022979
132positive regulation of vasculogenesis (GO:2001214)2.84947469
133chemical homeostasis within a tissue (GO:0048875)2.84827193
134negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.83985099
135regulation of female receptivity (GO:0045924)2.83386305
136growth hormone receptor signaling pathway (GO:0060396)2.82693305
137termination of signal transduction (GO:0023021)2.82175706
138phospholipid homeostasis (GO:0055091)2.81560955
139protein localization to endosome (GO:0036010)2.80920380
140phagocytosis, engulfment (GO:0006911)2.80509960
141negative regulation of interleukin-17 production (GO:0032700)2.80200302
142fibroblast migration (GO:0010761)2.79759952
143transcytosis (GO:0045056)2.79140169
144insulin-like growth factor receptor signaling pathway (GO:0048009)2.79014057
145stress fiber assembly (GO:0043149)2.78101406
146tricarboxylic acid cycle (GO:0006099)2.77933355
147lipid oxidation (GO:0034440)2.77537048
148fatty acid elongation (GO:0030497)2.77502991
149protein localization to cell surface (GO:0034394)2.76920869
150negative regulation of endothelial cell proliferation (GO:0001937)2.76775538
151wound healing, spreading of epidermal cells (GO:0035313)2.76335030
152negative regulation of calcium ion transport into cytosol (GO:0010523)2.75934486
153regulation of norepinephrine secretion (GO:0014061)2.75923618
154negative regulation of protein localization to plasma membrane (GO:1903077)2.75031462
155carnitine transmembrane transport (GO:1902603)2.74302417
156regulation of coagulation (GO:0050818)2.74170617
157glomerular basement membrane development (GO:0032836)2.73474245
158cell-substrate junction assembly (GO:0007044)2.73260167
159regulation of mast cell degranulation (GO:0043304)2.72529493
160cyclooxygenase pathway (GO:0019371)2.72473486
161endothelium development (GO:0003158)2.72047906
162negative regulation of protein autophosphorylation (GO:0031953)2.71609692
163positive regulation of endothelial cell differentiation (GO:0045603)2.71343549
164ovulation (GO:0030728)2.70376973
165regulation of integrin-mediated signaling pathway (GO:2001044)2.69816362
166fatty acid catabolic process (GO:0009062)2.67319118
167negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.67295872
168relaxation of smooth muscle (GO:0044557)2.67228571
169blood vessel remodeling (GO:0001974)2.66375716
170regulation of inositol phosphate biosynthetic process (GO:0010919)2.66341795
171regulation of p38MAPK cascade (GO:1900744)2.65714776
172positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64839512
173positive regulation of granulocyte differentiation (GO:0030854)2.64308599
174positive regulation of mast cell activation involved in immune response (GO:0033008)2.63971239
175positive regulation of mast cell degranulation (GO:0043306)2.63971239
176regulation of T-helper 1 cell differentiation (GO:0045625)2.63171915
177regulation of mast cell activation involved in immune response (GO:0033006)2.62642359
178regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.62419260
179high-density lipoprotein particle remodeling (GO:0034375)2.60891037
180epithelial cell-cell adhesion (GO:0090136)2.60746916
181positive regulation of lipid storage (GO:0010884)2.60567420
182epoxygenase P450 pathway (GO:0019373)2.57941841
183positive regulation of endothelial cell apoptotic process (GO:2000353)2.57295029
184positive regulation of p38MAPK cascade (GO:1900745)2.57235044
185negative regulation of fatty acid transport (GO:2000192)2.55134816
186actin-myosin filament sliding (GO:0033275)2.52845489
187muscle filament sliding (GO:0030049)2.52845489
188endocardial cushion development (GO:0003197)2.52495762
189myofibril assembly (GO:0030239)2.51878376
190positive regulation of cellular response to insulin stimulus (GO:1900078)2.51373995
191hemidesmosome assembly (GO:0031581)2.51150617
192adherens junction assembly (GO:0034333)2.49268536
193hippo signaling (GO:0035329)2.48903170
194amino-acid betaine transport (GO:0015838)2.48509366
195carnitine transport (GO:0015879)2.48509366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.20250903
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.73593332
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.52220661
4CLOCK_20551151_ChIP-Seq_293T_Human4.31243899
5SCL_19346495_ChIP-Seq_HPC-7_Human3.99516118
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.99301525
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.90163387
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.87997370
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.26281525
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.05685233
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.99815322
12GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.96692094
13GATA1_22025678_ChIP-Seq_K562_Human2.70402639
14* EP300_21415370_ChIP-Seq_HL-1_Mouse2.70082669
15LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.66548687
16GATA2_21666600_ChIP-Seq_HMVEC_Human2.48087377
17* GATA2_19941826_ChIP-Seq_K562_Human2.44824739
18GATA1_19941827_ChIP-Seq_MEL_Mouse2.44697584
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.41362635
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37940648
21EZH2_22144423_ChIP-Seq_EOC_Human2.35244122
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.31397237
23* SPI1_23127762_ChIP-Seq_K562_Human2.26939250
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22317355
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.21285683
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18105921
27PPAR_26484153_Chip-Seq_NCI-H1993_Human2.16181240
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14461573
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14403145
30* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.11789440
31TBX20_22328084_ChIP-Seq_HEART_Mouse2.10746183
32TBX20_22080862_ChIP-Seq_HEART_Mouse2.10746183
33TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.07314816
34* CJUN_26792858_Chip-Seq_BT549_Human2.07057183
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.03206851
36GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.99726456
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97794317
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.95862611
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.93913421
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.93243046
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.92250906
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83955005
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83696762
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83532273
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.82461559
46GATA1_22383799_ChIP-Seq_G1ME_Mouse1.82167222
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.79541413
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.78771279
49RUNX_20019798_ChIP-Seq_JUKART_Human1.75470401
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74257102
51GBX2_23144817_ChIP-Seq_PC3_Human1.72833359
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72357557
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72121642
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.71864703
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.67950756
56ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67747623
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67585997
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65377050
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.65041781
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63897289
61PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.62594936
62* ELK3_25401928_ChIP-Seq_HUVEC_Human1.61924982
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57341993
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.55229989
65PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54890211
66* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54222215
67* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54222215
68GATA1_19941827_ChIP-Seq_MEL86_Mouse1.51968679
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50456364
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49465431
71HTT_18923047_ChIP-ChIP_STHdh_Human1.48176048
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.47807920
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46927633
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45169631
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45169631
76* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44191103
77* FOXO3_23340844_ChIP-Seq_DLD1_Human1.43512106
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.42616605
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42111317
80ZNF263_19887448_ChIP-Seq_K562_Human1.41747043
81* SOX2_20726797_ChIP-Seq_SW620_Human1.40462903
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40444558
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39895669
84* BRD4_25478319_ChIP-Seq_HGPS_Human1.38806997
85* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.37098648
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35902527
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33508812
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25239700
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23337277
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23144149
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21948138
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21611862
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20696568
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20419777
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19319559
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19086694
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17088249
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16678362
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15580408
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13779425
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13432418
102KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.13190249
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11588427
104SALL4_22934838_ChIP-ChIP_CD34+_Human1.10693004
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09506743
106GATA1_19941826_ChIP-Seq_K562_Human1.08918400
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08166953
108* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07946930
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06589563
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05478458
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05407954
112* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04796210
113STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04392655
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02808221
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02002371
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00468963
117TP53_16413492_ChIP-PET_HCT116_Human1.00289810
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00064988
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99763196
120MYB_26560356_Chip-Seq_TH2_Human0.99285464
121* TCF4_18268006_ChIP-ChIP_LS174T_Human0.99278188
122SPI1_20517297_ChIP-Seq_HL60_Human0.99174747
123UBF1/2_26484160_Chip-Seq_HMECs_Human0.98125367
124BCAT_22108803_ChIP-Seq_LS180_Human0.97344524
125SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96898102
126GATA3_27048872_Chip-Seq_THYMUS_Human0.96232476
127ATF3_27146783_Chip-Seq_COLON_Human0.95750000
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95524320
129SPI1_23547873_ChIP-Seq_NB4_Human0.95040380
130* TP53_18474530_ChIP-ChIP_U2OS_Human0.94471038
131RACK7_27058665_Chip-Seq_MCF-7_Human0.92856399
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91953189
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91949732
134* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91430191
135TAF15_26573619_Chip-Seq_HEK293_Human0.90965880
136RXR_22108803_ChIP-Seq_LS180_Human0.90787871
137FOXA2_19822575_ChIP-Seq_HepG2_Human0.89651708
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.88615173
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.88332146
140AHR_22903824_ChIP-Seq_MCF-7_Human0.87905934
141EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86951369
142GATA3_26560356_Chip-Seq_TH2_Human0.86508759
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86359961
144STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85453249
145FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85019630
146VDR_24787735_ChIP-Seq_THP-1_Human0.83844491
147* NCOR1_26117541_ChIP-Seq_K562_Human0.83360240
148* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83041226
149OCT1_27270436_Chip-Seq_PROSTATE_Human0.82365290
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.81762369
151CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81279468
152* LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81106451
153RUNX1_27514584_Chip-Seq_MCF-7_Human0.80895479
154GATA3_24758297_ChIP-Seq_MCF-7_Human0.80526556
155STAT1_20625510_ChIP-Seq_HELA_Human0.80472417
156NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80368939
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80255190
158UTX_26944678_Chip-Seq_JUKART_Human0.79971362
159Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79459311
160PU_27001747_Chip-Seq_BMDM_Mouse0.79314627
161RNF2_18974828_ChIP-Seq_MESCs_Mouse0.79168354
162EZH2_18974828_ChIP-Seq_MESCs_Mouse0.79168354
163UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78792806
164CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78726123
165AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78610720
166SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.78156944
167VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78086589
168TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77290899
169EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76749224
170SMAD4_21799915_ChIP-Seq_A2780_Human0.76505945
171SMRT_27268052_Chip-Seq_Bcells_Human0.74573830
172VDR_22108803_ChIP-Seq_LS180_Human0.74149906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.66005112
2MP0008438_abnormal_cutaneous_collagen5.17156403
3MP0005670_abnormal_white_adipose3.84409320
4MP0010368_abnormal_lymphatic_system3.79097097
5MP0000465_gastrointestinal_hemorrhage3.37151481
6MP0004272_abnormal_basement_membrane3.35603563
7MP0005275_abnormal_skin_tensile3.31083084
8MP0001879_abnormal_lymphatic_vessel3.24989275
9MP0003705_abnormal_hypodermis_morpholog3.08301986
10MP0004130_abnormal_muscle_cell2.99678854
11MP0005666_abnormal_adipose_tissue2.77643408
12MP0002837_dystrophic_cardiac_calcinosis2.76658039
13MP0004084_abnormal_cardiac_muscle2.67463632
14MP0003303_peritoneal_inflammation2.59967482
15MP0001958_emphysema2.55955933
16MP0000013_abnormal_adipose_tissue2.46384726
17MP0004510_myositis2.44679392
18MP0004185_abnormal_adipocyte_glucose2.40772348
19MP0003279_aneurysm2.37022874
20MP0001835_abnormal_antigen_presentation2.35652054
21MP0003828_pulmonary_edema2.24027872
22MP0005375_adipose_tissue_phenotype2.19033305
23MP0006138_congestive_heart_failure2.13567158
24MP0003566_abnormal_cell_adhesion2.02198685
25MP0003950_abnormal_plasma_membrane2.02148169
26MP0000751_myopathy2.00293615
27MP0005167_abnormal_blood-brain_barrier1.90823270
28MP0003724_increased_susceptibility_to1.89818483
29MP0005083_abnormal_biliary_tract1.88937822
30MP0004215_abnormal_myocardial_fiber1.82403966
31MP0005330_cardiomyopathy1.80453295
32MP0000003_abnormal_adipose_tissue1.78675596
33MP0004036_abnormal_muscle_relaxation1.76741891
34MP0000750_abnormal_muscle_regeneration1.76099683
35MP0008775_abnormal_heart_ventricle1.74782330
36MP0005623_abnormal_meninges_morphology1.74726414
37MP0001544_abnormal_cardiovascular_syste1.70308078
38MP0005385_cardiovascular_system_phenoty1.70308078
39MP0001851_eye_inflammation1.65608917
40MP0006054_spinal_hemorrhage1.63501410
41MP0004087_abnormal_muscle_fiber1.56930382
42MP0002148_abnormal_hypersensitivity_rea1.56174699
43MP0005503_abnormal_tendon_morphology1.55524738
44MP0000749_muscle_degeneration1.53825874
45MP0002972_abnormal_cardiac_muscle1.53233514
46MP0002132_abnormal_respiratory_system1.52944996
47MP0005084_abnormal_gallbladder_morpholo1.52410522
48MP0003191_abnormal_cellular_cholesterol1.51796028
49MP0000343_altered_response_to1.49388437
50MP0003638_abnormal_response/metabolism_1.48399697
51MP0005000_abnormal_immune_tolerance1.48192974
52MP0010155_abnormal_intestine_physiology1.47618449
53MP0002295_abnormal_pulmonary_circulatio1.46573496
54MP0003091_abnormal_cell_migration1.46493263
55MP0002971_abnormal_brown_adipose1.44818096
56MP0005620_abnormal_muscle_contractility1.44210141
57MP0000767_abnormal_smooth_muscle1.43307464
58MP0010630_abnormal_cardiac_muscle1.42573828
59MP0005397_hematopoietic_system_phenotyp1.42170051
60MP0001545_abnormal_hematopoietic_system1.42170051
61MP0005671_abnormal_response_to1.38805791
62MP0005058_abnormal_lysosome_morphology1.38297789
63MP0003436_decreased_susceptibility_to1.36905871
64MP0001533_abnormal_skeleton_physiology1.36819597
65MP0009384_cardiac_valve_regurgitation1.36037078
66MP0005410_abnormal_fertilization1.33118794
67MP0002736_abnormal_nociception_after1.32674655
68MP0008872_abnormal_physiological_respon1.30936446
69MP0002398_abnormal_bone_marrow1.30452628
70MP0004484_altered_response_of1.30242619
71MP0009115_abnormal_fat_cell1.29395028
72MP0001663_abnormal_digestive_system1.28765331
73MP0000858_altered_metastatic_potential1.25721435
74MP0002723_abnormal_immune_serum1.20203074
75MP0009763_increased_sensitivity_to1.19291924
76MP0003045_fibrosis1.19021225
77MP0002332_abnormal_exercise_endurance1.18793821
78MP0005595_abnormal_vascular_smooth1.17883074
79MP0009780_abnormal_chondrocyte_physiolo1.13617134
80MP0001800_abnormal_humoral_immune1.13043125
81MP0004947_skin_inflammation1.13007064
82MP0010329_abnormal_lipoprotein_level1.12594805
83MP0002452_abnormal_antigen_presenting1.11808584
84MP0002128_abnormal_blood_circulation1.11705890
85MP0002060_abnormal_skin_morphology1.10970192
86MP0000759_abnormal_skeletal_muscle1.09998495
87MP0002419_abnormal_innate_immunity1.09713159
88MP0000733_abnormal_muscle_development1.07981812
89MP0005388_respiratory_system_phenotype1.06768715
90MP0002133_abnormal_respiratory_system1.06768715
91MP0005164_abnormal_response_to1.06538636
92MP0009764_decreased_sensitivity_to1.05692596
93MP0000249_abnormal_blood_vessel1.04542104
94MP0005023_abnormal_wound_healing1.02858391
95MP0003656_abnormal_erythrocyte_physiolo1.02668756
96MP0005334_abnormal_fat_pad1.00764719
97MP0002420_abnormal_adaptive_immunity1.00346550
98MP0003879_abnormal_hair_cell0.99043856
99MP0001819_abnormal_immune_cell0.98698362
100MP0002108_abnormal_muscle_morphology0.98489717
101MP0005165_increased_susceptibility_to0.97126828
102MP0000689_abnormal_spleen_morphology0.97002820
103MP0003075_altered_response_to0.96313639
104MP0003866_abnormal_defecation0.95982088
105MP0002429_abnormal_blood_cell0.94847769
106MP0005025_abnormal_response_to0.94529755
107MP0005409_darkened_coat_color0.94364011
108MP0008874_decreased_physiological_sensi0.94126175
109MP0001614_abnormal_blood_vessel0.93794070
110MP0001664_abnormal_digestion0.93123023
111MP0002733_abnormal_thermal_nociception0.92215333
112MP0002998_abnormal_bone_remodeling0.90662841
113MP0005387_immune_system_phenotype0.90404409
114MP0001790_abnormal_immune_system0.90404409
115MP0004147_increased_porphyrin_level0.89605783
116MP0002106_abnormal_muscle_physiology0.89016220
117MP0010352_gastrointestinal_tract_polyps0.88694494
118MP0004782_abnormal_surfactant_physiolog0.88281409
119MP0002168_other_aberrant_phenotype0.88199431
120MP0001845_abnormal_inflammatory_respons0.87501947
121MP0002118_abnormal_lipid_homeostasis0.85771890
122MP0003959_abnormal_lean_body0.85369298
123MP0002925_abnormal_cardiovascular_devel0.84615785
124MP0005369_muscle_phenotype0.83304199
125MP0008004_abnormal_stomach_pH0.83236648
126MP0000716_abnormal_immune_system0.83220770
127MP0002722_abnormal_immune_system0.83124611
128MP0003300_gastrointestinal_ulcer0.82702023
129MP0009642_abnormal_blood_homeostasis0.82096408
130MP0000266_abnormal_heart_morphology0.81934253
131MP0002970_abnormal_white_adipose0.80705080
132MP0001661_extended_life_span0.80596528
133MP0005646_abnormal_pituitary_gland0.80300923
134MP0000685_abnormal_immune_system0.79743501
135MP0004883_abnormal_blood_vessel0.78187084
136MP0005381_digestive/alimentary_phenotyp0.77981775
137MP0004085_abnormal_heartbeat0.77705484
138MP0009333_abnormal_splenocyte_physiolog0.77030840
139MP0003806_abnormal_nucleotide_metabolis0.76193804
140MP0005508_abnormal_skeleton_morphology0.75770359
141MP0009379_abnormal_foot_pigmentation0.74965423
142MP0009697_abnormal_copulation0.74860870
143MP0005535_abnormal_body_temperature0.74586002
144MP0001968_abnormal_touch/_nociception0.74429879
145MP0009765_abnormal_xenobiotic_induced0.73714226
146MP0002877_abnormal_melanocyte_morpholog0.73524982
147MP0006276_abnormal_autonomic_nervous0.72887500
148MP0000015_abnormal_ear_pigmentation0.72115738
149MP0002896_abnormal_bone_mineralization0.71703237
150MP0006036_abnormal_mitochondrial_physio0.70809107
151MP0003646_muscle_fatigue0.70063093
152MP0000230_abnormal_systemic_arterial0.69512431
153MP0001542_abnormal_bone_strength0.68239543
154MP0001175_abnormal_lung_morphology0.65529318
155MP0003137_abnormal_impulse_conducting0.65082522
156MP0002166_altered_tumor_susceptibility0.64899262
157MP0000747_muscle_weakness0.63341659
158MP0002269_muscular_atrophy0.62921256
159MP0003567_abnormal_fetal_cardiomyocyte0.62169244
160MP0003221_abnormal_cardiomyocyte_apopto0.60966888
161MP0002127_abnormal_cardiovascular_syste0.60275468
162MP0002138_abnormal_hepatobiliary_system0.58790268
163MP0001177_atelectasis0.57524685
164MP0001881_abnormal_mammary_gland0.55570671

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)9.57534454
2Petechiae (HP:0000967)8.92020249
3Purpura (HP:0000979)8.25379403
4Epistaxis (HP:0000421)7.64114508
5Gingival bleeding (HP:0000225)6.55990667
6Abnormal platelet function (HP:0011869)5.76927904
7Impaired platelet aggregation (HP:0003540)5.76927904
8Hyperlipoproteinemia (HP:0010980)5.72228028
9Premature rupture of membranes (HP:0001788)5.06910958
10Protrusio acetabuli (HP:0003179)4.74578824
11Increased connective tissue (HP:0009025)4.61096784
12Broad metatarsal (HP:0001783)4.21924573
13Cerebral aneurysm (HP:0004944)4.12009684
14Poikilocytosis (HP:0004447)3.97280865
15Muscle fiber splitting (HP:0003555)3.93043021
16Dyschromatopsia (HP:0007641)3.82458111
17Acanthosis nigricans (HP:0000956)3.79927081
18Conjunctival telangiectasia (HP:0000524)3.79876343
19Acanthocytosis (HP:0001927)3.78583690
20Aortic dissection (HP:0002647)3.77360051
21Aortic aneurysm (HP:0004942)3.72896616
22Spinal rigidity (HP:0003306)3.72525735
23Ankle contracture (HP:0006466)3.64681986
24Hematochezia (HP:0002573)3.63140724
25Right ventricular cardiomyopathy (HP:0011663)3.47960300
26Bruising susceptibility (HP:0000978)3.46158803
27Increased variability in muscle fiber diameter (HP:0003557)3.45778456
28Type 1 muscle fiber predominance (HP:0003803)3.42523811
29Lipoatrophy (HP:0100578)3.37670437
30Abnormality of the vasculature of the conjunctiva (HP:0008054)3.35381592
31Abnormality of the common coagulation pathway (HP:0010990)3.34618297
32Polycythemia (HP:0001901)3.34060448
33Hyporeflexia of lower limbs (HP:0002600)3.33788117
34Difficulty running (HP:0009046)3.22773179
35Sudden death (HP:0001699)3.19738407
36Abnormal pupillary function (HP:0007686)3.19560001
37Shallow orbits (HP:0000586)3.17632070
38Ventricular tachycardia (HP:0004756)3.16787574
39Abnormality of skeletal muscle fiber size (HP:0012084)3.12066012
40Oligomenorrhea (HP:0000876)3.02084101
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.98133786
42Joint hemorrhage (HP:0005261)2.96875244
43Atrial fibrillation (HP:0005110)2.96123036
44Atrophic scars (HP:0001075)2.91241636
45Paralysis (HP:0003470)2.84757126
46Myoglobinuria (HP:0002913)2.83462446
47Hypertriglyceridemia (HP:0002155)2.78047925
48Aneurysm (HP:0002617)2.75886552
49Primary atrial arrhythmia (HP:0001692)2.70413176
50Supraventricular arrhythmia (HP:0005115)2.69278809
51Hepatosplenomegaly (HP:0001433)2.68762271
52Reduced subcutaneous adipose tissue (HP:0003758)2.62919120
53Dilatation of the ascending aorta (HP:0005111)2.61808740
54Increased density of long bones (HP:0006392)2.59751801
55Mitral valve prolapse (HP:0001634)2.59648309
56Lymphangioma (HP:0100764)2.58920408
57Difficulty climbing stairs (HP:0003551)2.58840156
58Supraventricular tachycardia (HP:0004755)2.55599651
59Joint swelling (HP:0001386)2.53770518
60Stomatitis (HP:0010280)2.53750246
61Decreased central vision (HP:0007663)2.49487211
62Mildly elevated creatine phosphokinase (HP:0008180)2.49101205
63Peritonitis (HP:0002586)2.48494566
64Soft skin (HP:0000977)2.48357944
65Scapular winging (HP:0003691)2.45616097
66Abnormality of iron homeostasis (HP:0011031)2.44935953
67Fragile skin (HP:0001030)2.42400629
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.41650756
69Osteolytic defects of the hand bones (HP:0009699)2.41650756
70Xanthomatosis (HP:0000991)2.40418764
71Dilated cardiomyopathy (HP:0001644)2.37981381
72Abnormality of lateral ventricle (HP:0030047)2.37807476
73Spontaneous hematomas (HP:0007420)2.37529107
74Tinnitus (HP:0000360)2.33996811
75Abnormality of macrophages (HP:0004311)2.32595493
76Venous abnormality (HP:0002624)2.31961236
77Growth hormone excess (HP:0000845)2.28601070
78Bladder diverticulum (HP:0000015)2.26727311
79Abnormality of transition element cation homeostasis (HP:0011030)2.26042541
80Rhabdomyolysis (HP:0003201)2.25203984
81Myotonia (HP:0002486)2.24758371
82Arterial thrombosis (HP:0004420)2.24407230
83Exercise-induced muscle cramps (HP:0003710)2.24364602
84Exercise-induced myalgia (HP:0003738)2.24131513
85Follicular hyperkeratosis (HP:0007502)2.22991515
86Abnormality of the calf musculature (HP:0001430)2.22823617
87Increased IgM level (HP:0003496)2.22772328
88Abnormal auditory evoked potentials (HP:0006958)2.22582363
89Abnormality of the nasal mucosa (HP:0000433)2.21107675
90Visceral angiomatosis (HP:0100761)2.20679993
91Hypoalphalipoproteinemia (HP:0003233)2.18109297
92Bone cyst (HP:0012062)2.16732444
93Long toe (HP:0010511)2.16703349
94Cervical subluxation (HP:0003308)2.16664364
95Facial diplegia (HP:0001349)2.11512916
96Ventricular fibrillation (HP:0001663)2.11499185
97Insulin-resistant diabetes mellitus (HP:0000831)2.10299755
98Increased mean platelet volume (HP:0011877)2.10235026
99Vascular tortuosity (HP:0004948)2.09949176
100Hypoglycemic coma (HP:0001325)2.09691571
101Rectal prolapse (HP:0002035)2.08935456
102Camptodactyly of toe (HP:0001836)2.08499939
103Insulin resistance (HP:0000855)2.08025606
104Hemangiomatosis (HP:0007461)2.06084398
105Spontaneous abortion (HP:0005268)2.05150461
106Blue sclerae (HP:0000592)2.05059224
107Esophageal varix (HP:0002040)2.04009951
108EMG: myopathic abnormalities (HP:0003458)2.02296804
109Cerebral hemorrhage (HP:0001342)2.02079287
110Venous insufficiency (HP:0005293)2.00696491
111Wrist flexion contracture (HP:0001239)2.00463779
112Prolonged bleeding time (HP:0003010)11.3124825
113Menorrhagia (HP:0000132)10.2357902
114Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98991562
115Pulmonary artery stenosis (HP:0004415)1.97262713
116Wormian bones (HP:0002645)1.96962985
117Upper limb muscle weakness (HP:0003484)1.95366855
118Obstructive lung disease (HP:0006536)1.94581197
119Chronic obstructive pulmonary disease (HP:0006510)1.94581197
120Asymmetric septal hypertrophy (HP:0001670)1.93954447
121Round ear (HP:0100830)1.93438986
122Deep venous thrombosis (HP:0002625)1.93086756
123Short nail (HP:0001799)1.92379599
124Encephalitis (HP:0002383)1.91695522
125Muscle stiffness (HP:0003552)1.91546431
126Buphthalmos (HP:0000557)1.91348737
127Calf muscle hypertrophy (HP:0008981)1.90785239
128Episodic fever (HP:0001954)1.90176386
129Palpitations (HP:0001962)1.88464032
130Eczematoid dermatitis (HP:0000976)1.87581983
131Autoimmune hemolytic anemia (HP:0001890)1.87369594
132Generalized aminoaciduria (HP:0002909)1.86356530
133Increased serum ferritin (HP:0003281)1.86323381
134Prolonged QT interval (HP:0001657)1.85165096
135Myocardial infarction (HP:0001658)1.85064558
136Vertigo (HP:0002321)1.84398600
137Hyperglycinuria (HP:0003108)1.84224936
138Hyperthyroidism (HP:0000836)1.84045048
139Nausea (HP:0002018)1.83541326
140Mucosal telangiectasiae (HP:0100579)1.82947435
141Abnormality of fatty-acid metabolism (HP:0004359)1.82856791
142Abnormal cartilage morphology (HP:0002763)1.82678128
143Subaortic stenosis (HP:0001682)1.81035670
144Abnormality of the left ventricular outflow tract (HP:0011103)1.81035670
145Papillary thyroid carcinoma (HP:0002895)1.80625059
146Cavernous hemangioma (HP:0001048)1.80205685
147Chest pain (HP:0100749)1.80133606
148Hemorrhage of the eye (HP:0011885)1.79627769
149Male infertility (HP:0003251)1.78758513
150Nonimmune hydrops fetalis (HP:0001790)1.78539143
151Abnormality of dentin (HP:0010299)1.78116229
152Arterial tortuosity (HP:0005116)1.74814426
153Thyroid-stimulating hormone excess (HP:0002925)1.73531559
154Distal lower limb amyotrophy (HP:0008944)1.73379855
155Ketoacidosis (HP:0001993)1.73154658
156Mitral stenosis (HP:0001718)1.67905669
157Abnormality of the prostate (HP:0008775)1.66963162
158Thrombocytosis (HP:0001894)1.65940427
159Biliary tract neoplasm (HP:0100574)1.65842067
160Thrombophlebitis (HP:0004418)1.61532125
161Central scotoma (HP:0000603)1.61110497
162Dysautonomia (HP:0002459)1.59501006
163Muscle fibrillation (HP:0010546)1.59056180
164Basal ganglia calcification (HP:0002135)1.57579464
165Hypophosphatemic rickets (HP:0004912)1.57496775
1663-Methylglutaconic aciduria (HP:0003535)1.54603780
167Recurrent abscess formation (HP:0002722)1.51803453
168Tongue fasciculations (HP:0001308)1.48522235
169Cerebral ischemia (HP:0002637)1.43757117
170Dysostosis multiplex (HP:0000943)1.42607257
171Portal hypertension (HP:0001409)1.41428170
172Testicular neoplasm (HP:0010788)1.41062536
173Bundle branch block (HP:0011710)1.40851825
174Elevated erythrocyte sedimentation rate (HP:0003565)1.39811632
175Type 2 muscle fiber atrophy (HP:0003554)1.39181636
176Pulmonary embolism (HP:0002204)1.39173175
177Muscle fiber atrophy (HP:0100295)1.39145920
178Leukocytosis (HP:0001974)1.37691646
179Hypoplasia of the fovea (HP:0007750)1.37117602
180Aplasia/Hypoplasia of the fovea (HP:0008060)1.37117602
181Visual hallucinations (HP:0002367)1.36707297
182Weak cry (HP:0001612)1.36405768
183Distal lower limb muscle weakness (HP:0009053)1.36093659
184Abnormality of the right ventricle (HP:0001707)1.35169084
185Recurrent bacterial skin infections (HP:0005406)1.33943486
186Arthropathy (HP:0003040)1.33042301
187Amaurosis fugax (HP:0100576)1.32996079
188Diplopia (HP:0000651)1.32960587
189Abnormality of binocular vision (HP:0011514)1.32960587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.12524035
2TIE16.07533200
3TRIB34.02797673
4MST44.02364061
5TTN3.59354850
6TEC3.34913728
7BTK3.05364011
8KDR2.99659534
9TGFBR22.99643446
10RIPK12.59741738
11MYLK2.52357979
12BMPR22.48757138
13TAOK32.48368535
14EIF2AK12.45528358
15CAMK1D2.44447410
16SYK2.26122973
17PKN22.15148229
18GRK52.14970294
19PDGFRA2.14608615
20SIK12.12273208
21ZAP702.10405808
22CSF1R2.08886982
23EPHB21.94273249
24LATS11.90822445
25BCKDK1.86338049
26DDR21.84379345
27PDK41.79910942
28PDK31.79910942
29PDK21.76628387
30LMTK21.74307326
31DMPK1.73061891
32ERN11.72257166
33FES1.71754014
34GRK61.65882442
35TGFBR11.61107415
36PTK2B1.58117703
37CAMK1G1.56647811
38PIK3CA1.51594431
39FER1.50465126
40HCK1.48918862
41BLK1.44487733
42FGR1.44417152
43TRPM71.39885354
44LRRK21.34294179
45PAK21.29004491
46FGFR21.25624270
47LATS21.23175414
48ILK1.23061639
49ITK1.20486795
50PTK61.15182751
51FGFR41.09659644
52PHKG11.07983592
53PHKG21.07983592
54EPHB11.07689233
55MAP2K31.06664752
56LYN1.05835122
57FRK1.05224438
58PRKD11.04626023
59MET1.03581484
60PAK11.03068151
61NEK91.02745021
62OBSCN1.00306179
63MAP3K30.98484853
64MST1R0.98088673
65FGFR30.97351245
66PLK20.95864853
67ADRBK20.95227121
68TXK0.94899435
69PRKAA20.94041149
70PTK20.93602829
71MARK30.93476690
72PAK40.92844149
73SIK30.90766104
74IRAK10.90739160
75TNK20.90084261
76PDGFRB0.89349819
77IKBKB0.89337123
78PAK30.87506861
79DAPK20.86891760
80PRKG20.86373811
81ACVR1B0.84256397
82INSRR0.83746600
83MAP3K50.83535527
84ERBB20.81628769
85ROCK10.81328463
86MAP2K10.81279419
87ADRBK10.80883849
88MATK0.78237145
89PRKCH0.75245526
90PDK10.71023542
91BMX0.70789499
92TLK10.69911741
93STK30.68696050
94JAK10.67970859
95MOS0.63848550
96PRKD30.63161252
97EEF2K0.60473716
98CSK0.59857644
99PIM20.58739138
100GRK10.58412231
101FGFR10.58048777
102PRKD20.57938882
103MTOR0.57646825
104LCK0.57319080
105RET0.55929892
106MUSK0.55489854
107CDK60.55039733
108EPHA30.53998881
109PRKACG0.53209252
110PDPK10.53201315
111IGF1R0.51945430
112STK40.51167251
113LIMK10.51090682
114MAPK120.50113094
115CAMKK20.48452264
116GSK3A0.48209765
117MAP3K110.47508090
118FYN0.47459859
119INSR0.46178396
120TAOK20.45971478
121WNK10.45915784
122PIK3CG0.44382951
123MAPKAPK30.44354725
124STK100.44110039
125CDK90.42948858
126MAP3K120.42900466
127PKN10.41964100
128MAP4K10.41670246
129ROCK20.41498661
130MAP3K10.40174688
131TESK10.39778859
132FLT30.39503166
133SRC0.38590091
134TNIK0.38056016
135STK240.37975308
136PRKG10.37771202
137DAPK30.37161132
138SGK20.36942435
139DAPK10.36007940
140BMPR1B0.34169458
141NUAK10.33280112
142PRKCQ0.32000985
143PRKAA10.31639821
144MAP3K70.31240104
145PRKCD0.30499376
146MAP3K60.30240037
147NLK0.29772856
148JAK30.28370208
149HIPK20.27325620
150YES10.27039625
151ZAK0.25998368
152STK38L0.25782910
153ABL20.25172393
154PRKCB0.24683065
155PRKCE0.24646810
156SGK30.23875210
157MARK20.23541751
158CAMK10.22914453
159EGFR0.22894075
160JAK20.22550462
161CDC42BPA0.22479067

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.60704076
2Propanoate metabolism_Homo sapiens_hsa006403.22856977
3PPAR signaling pathway_Homo sapiens_hsa033203.13150000
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.05513128
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.87209006
6ECM-receptor interaction_Homo sapiens_hsa045122.77037488
7Fatty acid degradation_Homo sapiens_hsa000712.73027473
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60910483
9Fatty acid metabolism_Homo sapiens_hsa012122.58524752
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.50704922
11Fatty acid biosynthesis_Homo sapiens_hsa000612.47518210
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.38782394
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.31998564
14Hematopoietic cell lineage_Homo sapiens_hsa046402.30698560
15Focal adhesion_Homo sapiens_hsa045102.29612703
16Dilated cardiomyopathy_Homo sapiens_hsa054142.17428166
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.11886261
18Arachidonic acid metabolism_Homo sapiens_hsa005901.97439313
19Chemokine signaling pathway_Homo sapiens_hsa040621.76263410
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74233894
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.73363608
22Caffeine metabolism_Homo sapiens_hsa002321.72856529
23Adherens junction_Homo sapiens_hsa045201.71001668
24Pyruvate metabolism_Homo sapiens_hsa006201.50356572
25Serotonergic synapse_Homo sapiens_hsa047261.47134980
26Glycerolipid metabolism_Homo sapiens_hsa005611.45222477
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44865940
28B cell receptor signaling pathway_Homo sapiens_hsa046621.38554286
29Carbon metabolism_Homo sapiens_hsa012001.36922240
30AMPK signaling pathway_Homo sapiens_hsa041521.36341241
31Proteoglycans in cancer_Homo sapiens_hsa052051.36074097
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.30670278
33Insulin resistance_Homo sapiens_hsa049311.26697733
34Viral myocarditis_Homo sapiens_hsa054161.25629979
35Olfactory transduction_Homo sapiens_hsa047401.25158277
36Amoebiasis_Homo sapiens_hsa051461.24689960
37Protein digestion and absorption_Homo sapiens_hsa049741.24547631
38Small cell lung cancer_Homo sapiens_hsa052221.22366854
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20369146
40Malaria_Homo sapiens_hsa051441.14447158
41Pancreatic secretion_Homo sapiens_hsa049721.14427797
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14361095
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12369210
44beta-Alanine metabolism_Homo sapiens_hsa004101.11813591
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11629490
46Tight junction_Homo sapiens_hsa045301.11183364
47Systemic lupus erythematosus_Homo sapiens_hsa053221.09206008
48Tryptophan metabolism_Homo sapiens_hsa003801.08213644
49Long-term depression_Homo sapiens_hsa047301.07941665
50Fat digestion and absorption_Homo sapiens_hsa049751.07232851
51Shigellosis_Homo sapiens_hsa051311.06597682
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06458760
53Platelet activation_Homo sapiens_hsa046111.02909465
54Osteoclast differentiation_Homo sapiens_hsa043800.98688308
55Phagosome_Homo sapiens_hsa041450.96186948
56Fatty acid elongation_Homo sapiens_hsa000620.95727007
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94905721
58Complement and coagulation cascades_Homo sapiens_hsa046100.94630913
59Alcoholism_Homo sapiens_hsa050340.92286809
60Choline metabolism in cancer_Homo sapiens_hsa052310.92206131
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91879843
62TGF-beta signaling pathway_Homo sapiens_hsa043500.90448345
63Insulin signaling pathway_Homo sapiens_hsa049100.90436310
64T cell receptor signaling pathway_Homo sapiens_hsa046600.90085383
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88319130
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87458962
67Linoleic acid metabolism_Homo sapiens_hsa005910.87085647
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86430067
69Circadian entrainment_Homo sapiens_hsa047130.85724707
70Nitrogen metabolism_Homo sapiens_hsa009100.83542051
71Rap1 signaling pathway_Homo sapiens_hsa040150.83483911
72Collecting duct acid secretion_Homo sapiens_hsa049660.81261030
73Graft-versus-host disease_Homo sapiens_hsa053320.79513722
74Peroxisome_Homo sapiens_hsa041460.79398644
75Butanoate metabolism_Homo sapiens_hsa006500.76838224
76Renin secretion_Homo sapiens_hsa049240.76561021
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76499173
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.76390431
79Leishmaniasis_Homo sapiens_hsa051400.76235031
80HIF-1 signaling pathway_Homo sapiens_hsa040660.75303693
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71913657
82Ovarian steroidogenesis_Homo sapiens_hsa049130.71849835
83Allograft rejection_Homo sapiens_hsa053300.70766171
84Non-small cell lung cancer_Homo sapiens_hsa052230.70569870
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70172715
86Morphine addiction_Homo sapiens_hsa050320.69952583
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69767977
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69703054
89Glucagon signaling pathway_Homo sapiens_hsa049220.69337965
90Hippo signaling pathway_Homo sapiens_hsa043900.68433847
91Phenylalanine metabolism_Homo sapiens_hsa003600.68371993
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67458171
93Sulfur metabolism_Homo sapiens_hsa009200.66583230
94Calcium signaling pathway_Homo sapiens_hsa040200.66208269
95Cardiac muscle contraction_Homo sapiens_hsa042600.65701077
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65599738
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64708375
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64589890
99Autoimmune thyroid disease_Homo sapiens_hsa053200.64346401
100Primary immunodeficiency_Homo sapiens_hsa053400.62773254
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.62424696
102Gastric acid secretion_Homo sapiens_hsa049710.62353259
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61335409
104Arginine biosynthesis_Homo sapiens_hsa002200.60588638
105Toxoplasmosis_Homo sapiens_hsa051450.60408591
106Pathways in cancer_Homo sapiens_hsa052000.57138587
107Bladder cancer_Homo sapiens_hsa052190.56906054
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.56677093
109Asthma_Homo sapiens_hsa053100.55648456
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.55317638
111Starch and sucrose metabolism_Homo sapiens_hsa005000.54332025
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53002286
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52315860
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.52181220
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51603494
116Melanoma_Homo sapiens_hsa052180.50698935
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50123969
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49608690
119MicroRNAs in cancer_Homo sapiens_hsa052060.48923690
120Legionellosis_Homo sapiens_hsa051340.48680084
121Endometrial cancer_Homo sapiens_hsa052130.48030776
122Renal cell carcinoma_Homo sapiens_hsa052110.47894802
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47857540
124Tyrosine metabolism_Homo sapiens_hsa003500.47482754
125Tuberculosis_Homo sapiens_hsa051520.46566111
126Cholinergic synapse_Homo sapiens_hsa047250.45664994
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.45143494
128Salivary secretion_Homo sapiens_hsa049700.45067129
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44893063
130Bile secretion_Homo sapiens_hsa049760.44046794
131VEGF signaling pathway_Homo sapiens_hsa043700.43986372
132Renin-angiotensin system_Homo sapiens_hsa046140.43837401
133Chronic myeloid leukemia_Homo sapiens_hsa052200.43596782
134Glutathione metabolism_Homo sapiens_hsa004800.43418349
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43205575
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43094036
137Salmonella infection_Homo sapiens_hsa051320.43006611
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.42854714
139Viral carcinogenesis_Homo sapiens_hsa052030.42113143
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41681228
141Glioma_Homo sapiens_hsa052140.41618149
142Notch signaling pathway_Homo sapiens_hsa043300.38385502
143Lysine degradation_Homo sapiens_hsa003100.38295145
144Staphylococcus aureus infection_Homo sapiens_hsa051500.38272347
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37603284
146Axon guidance_Homo sapiens_hsa043600.35870028
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34593302
148Chemical carcinogenesis_Homo sapiens_hsa052040.33628035
149Ras signaling pathway_Homo sapiens_hsa040140.32336430
150Endocytosis_Homo sapiens_hsa041440.31925846
151Pancreatic cancer_Homo sapiens_hsa052120.31415833
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.30726630
153Basal cell carcinoma_Homo sapiens_hsa052170.29791782
154cAMP signaling pathway_Homo sapiens_hsa040240.28300834
155Gap junction_Homo sapiens_hsa045400.28291446
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.27534837
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26137976
158FoxO signaling pathway_Homo sapiens_hsa040680.25417531
159ABC transporters_Homo sapiens_hsa020100.25009811
160Dorso-ventral axis formation_Homo sapiens_hsa043200.24749492
161Oxytocin signaling pathway_Homo sapiens_hsa049210.23703552

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