SDR16C5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1long-chain fatty acid biosynthetic process (GO:0042759)9.85592416
2fatty acid elongation (GO:0030497)9.46931533
3sphingoid metabolic process (GO:0046519)9.14153617
4sphingosine metabolic process (GO:0006670)8.18491220
5keratinization (GO:0031424)7.83005093
6surfactant homeostasis (GO:0043129)7.78990180
7diol metabolic process (GO:0034311)7.30434434
8multicellular organismal water homeostasis (GO:0050891)6.89201408
9keratinocyte differentiation (GO:0030216)6.74545454
10regulation of phospholipase A2 activity (GO:0032429)6.66787549
11long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.97108602
12water homeostasis (GO:0030104)5.80578077
13* keratinocyte proliferation (GO:0043616)5.63368178
14viral transcription (GO:0019083)5.59175856
15axonemal dynein complex assembly (GO:0070286)5.53495573
16interferon-gamma secretion (GO:0072643)5.34767637
17translational termination (GO:0006415)5.27022445
18long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.22128065
19epidermal cell differentiation (GO:0009913)5.15754536
20fatty-acyl-CoA metabolic process (GO:0035337)5.14718120
21regulation of chemokine secretion (GO:0090196)5.12466222
22glucosamine-containing compound catabolic process (GO:1901072)5.07787794
23molting cycle (GO:0042303)4.99436976
24hair cycle (GO:0042633)4.99436976
25regulation of ruffle assembly (GO:1900027)4.99325738
26linoleic acid metabolic process (GO:0043651)4.90056583
27keratinocyte development (GO:0003334)4.87191604
28ribosomal small subunit biogenesis (GO:0042274)4.80631920
29bundle of His cell to Purkinje myocyte communication (GO:0086069)4.78899075
30positive regulation of interleukin-8 secretion (GO:2000484)4.74295524
31detection of bacterium (GO:0016045)4.72168369
32positive regulation of chemokine secretion (GO:0090197)4.70090232
33fatty-acyl-CoA biosynthetic process (GO:0046949)4.69640932
34intestinal epithelial cell development (GO:0060576)4.69223432
35epidermis development (GO:0008544)4.60622774
36cilium or flagellum-dependent cell motility (GO:0001539)4.38056187
37establishment of planar polarity (GO:0001736)4.34246401
38establishment of tissue polarity (GO:0007164)4.34246401
39one-carbon compound transport (GO:0019755)4.28235381
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.25861995
41regulation of cell proliferation involved in kidney development (GO:1901722)4.24153310
42peptide cross-linking (GO:0018149)4.23793261
43protein targeting to ER (GO:0045047)4.22701378
44cotranslational protein targeting to membrane (GO:0006613)4.20913756
45translational elongation (GO:0006414)4.14018962
46establishment of protein localization to endoplasmic reticulum (GO:0072599)4.13189442
47viral life cycle (GO:0019058)4.09754655
48pyrimidine-containing compound transmembrane transport (GO:0072531)4.06960705
49cellular protein complex disassembly (GO:0043624)3.99885259
50protein localization to endoplasmic reticulum (GO:0070972)3.99426369
51lipoxygenase pathway (GO:0019372)3.95538389
52regulation of keratinocyte differentiation (GO:0045616)3.95100629
53detection of other organism (GO:0098543)3.94894780
54intermediate filament organization (GO:0045109)3.85313750
55cyclooxygenase pathway (GO:0019371)3.84445318
56regulation of interleukin-8 secretion (GO:2000482)3.78608598
57negative regulation of lipase activity (GO:0060192)3.75979268
58regulation of transforming growth factor beta1 production (GO:0032908)3.75507801
59nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.74879591
60sodium ion homeostasis (GO:0055078)3.71352080
61primary alcohol catabolic process (GO:0034310)3.66586821
62hemidesmosome assembly (GO:0031581)3.65076227
63cilium movement (GO:0003341)3.64370546
64negative regulation of keratinocyte proliferation (GO:0010839)3.60659342
65prostanoid biosynthetic process (GO:0046457)3.60104611
66prostaglandin biosynthetic process (GO:0001516)3.60104611
67G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.58700094
68thioester biosynthetic process (GO:0035384)3.58483031
69acyl-CoA biosynthetic process (GO:0071616)3.58483031
70dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.57364538
71gap junction assembly (GO:0016264)3.56629463
72sphingolipid biosynthetic process (GO:0030148)3.55442792
73negative regulation of humoral immune response (GO:0002921)3.50360199
74phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.48359287
75cardiolipin metabolic process (GO:0032048)3.47455816
76very long-chain fatty acid metabolic process (GO:0000038)3.45252024
77iron ion import (GO:0097286)3.44791923
78sphingomyelin metabolic process (GO:0006684)3.42973995
79negative regulation of complement activation (GO:0045916)3.42930549
80phosphatidylinositol acyl-chain remodeling (GO:0036149)3.42467412
81positive regulation of vesicle fusion (GO:0031340)3.39977275
82calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.37114824
83protein complex disassembly (GO:0043241)3.32256251
84maturation of SSU-rRNA (GO:0030490)3.31815975
85regulation of glomerular filtration (GO:0003093)3.30897254
86intermediate filament cytoskeleton organization (GO:0045104)3.30205201
87ceramide catabolic process (GO:0046514)3.26514023
88eyelid development in camera-type eye (GO:0061029)3.25826321
89gland morphogenesis (GO:0022612)3.20885868
90positive regulation of epidermal cell differentiation (GO:0045606)3.20693042
91phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.20306288
92negative regulation of acute inflammatory response (GO:0002674)3.18335364
93ectoderm development (GO:0007398)3.17570927
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15669953
95intermediate filament-based process (GO:0045103)3.14688320
96negative regulation of interferon-gamma production (GO:0032689)3.14664115
97motile cilium assembly (GO:0044458)3.14150088
98cellular response to antibiotic (GO:0071236)3.12960874
99translational initiation (GO:0006413)3.12872394
100ethanol metabolic process (GO:0006067)3.12436947
101chemical homeostasis within a tissue (GO:0048875)3.11873840
102protein targeting to membrane (GO:0006612)3.11011705
103diterpenoid biosynthetic process (GO:0016102)3.10511987
104protein heterotetramerization (GO:0051290)3.08822210
105renal absorption (GO:0070293)3.08068244
106skin morphogenesis (GO:0043589)3.07478691
107regulation of hypersensitivity (GO:0002883)3.06995070
108vitamin transmembrane transport (GO:0035461)3.03782597
109phosphatidylcholine acyl-chain remodeling (GO:0036151)3.02682189
110unsaturated fatty acid biosynthetic process (GO:0006636)3.02513786
111prostaglandin metabolic process (GO:0006693)3.00010661
112prostanoid metabolic process (GO:0006692)3.00010661
113macromolecular complex disassembly (GO:0032984)2.99813634
114cardiac right ventricle morphogenesis (GO:0003215)2.95397770
115response to phenylpropanoid (GO:0080184)2.95157869
116O-glycan processing (GO:0016266)2.94773473
117epithelial cell differentiation involved in prostate gland development (GO:0060742)2.92875526
118negative regulation of protein activation cascade (GO:2000258)2.92083789
119hypotonic response (GO:0006971)2.92037508
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89328944
121negative regulation of interleukin-2 production (GO:0032703)2.88203557
122phosphatidylserine acyl-chain remodeling (GO:0036150)2.87277368
123positive regulation of glomerulus development (GO:0090193)2.87228313
124ribosomal small subunit assembly (GO:0000028)2.87006562
125phospholipid scrambling (GO:0017121)2.86798538
126regulation of epidermal cell differentiation (GO:0045604)2.86735976
127negative regulation of kidney development (GO:0090185)2.86602470
128negative regulation of stress fiber assembly (GO:0051497)2.86588322
129phosphate ion transmembrane transport (GO:0035435)2.86088486
130positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.85666968
131epithelial cilium movement (GO:0003351)2.85329927
132lateral sprouting from an epithelium (GO:0060601)2.81810999
133inositol phosphate-mediated signaling (GO:0048016)2.80989584
134phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.79417388
135regulation of keratinocyte proliferation (GO:0010837)2.78336336
136copper ion transport (GO:0006825)2.77707014
137regulation of integrin-mediated signaling pathway (GO:2001044)2.76214641
138positive regulation of epidermis development (GO:0045684)2.75957357
139polyol transport (GO:0015791)2.75913378
140glutathione biosynthetic process (GO:0006750)2.74251264
141regulation of cholesterol homeostasis (GO:2000188)2.72280387
142positive regulation of interleukin-4 production (GO:0032753)2.71615228
143cellular sodium ion homeostasis (GO:0006883)2.69193792
144tight junction assembly (GO:0070830)2.67312202
145regulation of epidermis development (GO:0045682)2.65874514
146cell-cell junction assembly (GO:0007043)2.64130258
147phosphatidylserine metabolic process (GO:0006658)2.62928456
148phosphate ion transport (GO:0006817)2.62137453
149apical protein localization (GO:0045176)2.58598071
150smooth muscle tissue development (GO:0048745)2.57500074
151negative regulation of T cell differentiation in thymus (GO:0033085)2.56010757
152epithelium development (GO:0060429)2.54329897
153cerebellar Purkinje cell differentiation (GO:0021702)2.51461263
154lung lobe morphogenesis (GO:0060463)2.49134173
155regulation of glomerulus development (GO:0090192)2.48700138
156polarized epithelial cell differentiation (GO:0030859)2.47202660
157glomerular epithelial cell development (GO:0072310)2.47129886
158regulation of axon regeneration (GO:0048679)2.45627467
159regulation of neuron projection regeneration (GO:0070570)2.45627467
160renal system process involved in regulation of blood volume (GO:0001977)2.45174330
161regulation of metalloenzyme activity (GO:0048552)2.43672187
162muscle cell migration (GO:0014812)2.43369470
163negative regulation of dendrite morphogenesis (GO:0050774)2.43354529
164negative regulation of epidermal cell differentiation (GO:0045605)2.41648096
165ventricular cardiac muscle cell action potential (GO:0086005)2.41562781
166desmosome organization (GO:0002934)14.5049609
167establishment of skin barrier (GO:0061436)10.9256852
168regulation of water loss via skin (GO:0033561)10.1425245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.81731329
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.17723901
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.93770435
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.80347776
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49231533
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.38136955
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10078374
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.03238007
9ZNF263_19887448_ChIP-Seq_K562_Human2.01349409
10TP63_17297297_ChIP-ChIP_HaCaT_Human15.5121587
11ESR2_21235772_ChIP-Seq_MCF-7_Human1.81376627
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81335770
13FOXO3_23340844_ChIP-Seq_DLD1_Human1.77382745
14SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70332395
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69228800
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69228800
17* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.68981919
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65797397
19ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61061751
20GATA1_22025678_ChIP-Seq_K562_Human1.58917511
21AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.56488564
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55982179
23SOX2_20726797_ChIP-Seq_SW620_Human1.54838247
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42514945
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42110308
26RXR_22108803_ChIP-Seq_LS180_Human1.41338077
27TP63_23658742_ChIP-Seq_EP156T_Human1.40611816
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36854536
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36854536
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.35733101
31BCAT_22108803_ChIP-Seq_LS180_Human1.33416760
32TP63_22573176_ChIP-Seq_HFKS_Human1.29884720
33VDR_22108803_ChIP-Seq_LS180_Human1.29647592
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26851635
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.26001060
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25275075
37BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24408003
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24239345
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21737652
40TP53_18474530_ChIP-ChIP_U2OS_Human1.21620467
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.21106959
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.20702107
43FOXA1_25552417_ChIP-Seq_VCAP_Human1.18545677
44KLF5_25053715_ChIP-Seq_YYC3_Human1.17809259
45GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.14487192
46GATA4_25053715_ChIP-Seq_YYC3_Human1.14436625
47AR_21572438_ChIP-Seq_LNCaP_Human1.12330339
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11869158
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10448217
50ELF5_23300383_ChIP-Seq_T47D_Human1.09314947
51* CJUN_26792858_Chip-Seq_BT549_Human1.08897955
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02616999
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.01867517
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00926705
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.00192506
56GATA3_24758297_ChIP-Seq_MCF-7_Human0.99882599
57GATA2_21666600_ChIP-Seq_HMVEC_Human0.98512950
58FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97648984
59PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97224909
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97123083
61* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95684149
62GATA6_21074721_ChIP-Seq_CACO-2_Human0.94598787
63AHR_22903824_ChIP-Seq_MCF-7_Human0.94555422
64SMAD_19615063_ChIP-ChIP_OVARY_Human0.94393911
65NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94296305
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93819457
67EZH2_27304074_Chip-Seq_ESCs_Mouse0.93032015
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92855806
69CDX2_22108803_ChIP-Seq_LS180_Human0.92742005
70TCF4_22108803_ChIP-Seq_LS180_Human0.91878976
71SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91761432
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91657428
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90036527
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89768584
75CEBPB_22108803_ChIP-Seq_LS180_Human0.89211349
76GATA6_25053715_ChIP-Seq_YYC3_Human0.88512874
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87858170
78* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87614864
79AR_21909140_ChIP-Seq_LNCAP_Human0.87434604
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87284967
81SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86242759
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85699102
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85106056
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84999649
85RACK7_27058665_Chip-Seq_MCF-7_Human0.83390327
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81791636
87EGR1_19032775_ChIP-ChIP_M12_Human0.81449510
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81031916
89EED_16625203_ChIP-ChIP_MESCs_Mouse0.79984541
90* ATF3_27146783_Chip-Seq_COLON_Human0.79600481
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79296172
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79281861
93FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79262119
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.78881473
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78862277
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78215781
97SMAD3_21741376_ChIP-Seq_HESCs_Human0.78169347
98UBF1/2_26484160_Chip-Seq_HMECs_Human0.78077425
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76375574
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74888842
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74781317
102SA1_27219007_Chip-Seq_Bcells_Human0.72890717
103JARID2_20075857_ChIP-Seq_MESCs_Mouse0.72822298
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72260853
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72194929
106RXR_22158963_ChIP-Seq_LIVER_Mouse0.71092458
107BMI1_23680149_ChIP-Seq_NPCS_Mouse0.70459763
108* SMAD4_21799915_ChIP-Seq_A2780_Human0.70217142
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69306308
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.68698552
111AR_25329375_ChIP-Seq_VCAP_Human0.67737462
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.67588353
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.66737506
114PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.66400039
115TBX20_22080862_ChIP-Seq_HEART_Mouse0.66219019
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.66219019
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.65838109
118TAF15_26573619_Chip-Seq_HEK293_Human0.65050971
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64739867
120CTCF_27219007_Chip-Seq_Bcells_Human0.64057761
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.63769365
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.63543081
123RBPJ_21746931_ChIP-Seq_IB4_Human0.63474251
124EZH2_27294783_Chip-Seq_ESCs_Mouse0.60921072
125RNF2_27304074_Chip-Seq_ESCs_Mouse0.60913057
126HNFA_21074721_ChIP-Seq_CACO-2_Human0.60544586
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.59432427
128JARID2_20064375_ChIP-Seq_MESCs_Mouse0.58851107
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.58618486
130SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.58556336
131LXR_22292898_ChIP-Seq_THP-1_Human0.58493104
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.58356232
133P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.58256266
134EZH2_18974828_ChIP-Seq_MESCs_Mouse0.57167934
135RNF2_18974828_ChIP-Seq_MESCs_Mouse0.57167934
136PHF8_20622853_ChIP-Seq_HELA_Human0.57003255
137LXR_22158963_ChIP-Seq_LIVER_Mouse0.56379130
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.56194132
139CLOCK_20551151_ChIP-Seq_293T_Human0.55987482
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.55867585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.27340433
2MP0003941_abnormal_skin_development5.20231850
3MP0005501_abnormal_skin_physiology5.10023900
4MP0010234_abnormal_vibrissa_follicle4.84755980
5MP0005275_abnormal_skin_tensile4.56860856
6MP0004381_abnormal_hair_follicle4.39146539
7MP0001216_abnormal_epidermal_layer3.56532449
8MP0002060_abnormal_skin_morphology3.55350628
9MP0003453_abnormal_keratinocyte_physiol3.37147971
10MP0010771_integument_phenotype3.24951481
11MP0003011_delayed_dark_adaptation3.15581156
12MP0002254_reproductive_system_inflammat3.07562753
13MP0000383_abnormal_hair_follicle2.94954106
14MP0002098_abnormal_vibrissa_morphology2.89477179
15MP0010678_abnormal_skin_adnexa2.71284784
16MP0000647_abnormal_sebaceous_gland2.61825008
17MP0004947_skin_inflammation2.45117364
18MP0009379_abnormal_foot_pigmentation2.44920469
19MP0005451_abnormal_body_composition2.43255452
20MP0000377_abnormal_hair_follicle2.32832132
21MP0001346_abnormal_lacrimal_gland2.22674373
22MP0000467_abnormal_esophagus_morphology2.21288946
23MP0000579_abnormal_nail_morphology2.19642944
24MP0002009_preneoplasia2.16915861
25MP0004185_abnormal_adipocyte_glucose2.15993180
26MP0004043_abnormal_pH_regulation1.98242762
27MP0000427_abnormal_hair_cycle1.96478817
28MP0000566_synostosis1.94345156
29MP0009931_abnormal_skin_appearance1.72979922
30MP0003705_abnormal_hypodermis_morpholog1.71167036
31MP0003566_abnormal_cell_adhesion1.70940701
32MP0001191_abnormal_skin_condition1.67964816
33MP0001984_abnormal_olfaction1.63489463
34MP0000367_abnormal_coat/_hair1.40382472
35MP0001243_abnormal_dermal_layer1.39907537
36MP0010352_gastrointestinal_tract_polyps1.39502485
37MP0001188_hyperpigmentation1.36004440
38MP0005083_abnormal_biliary_tract1.24065947
39MP0000762_abnormal_tongue_morphology1.23645849
40MP0000516_abnormal_urinary_system1.22915258
41MP0005367_renal/urinary_system_phenotyp1.22915258
42MP0001340_abnormal_eyelid_morphology1.21590772
43MP0001851_eye_inflammation1.14249355
44MP0008789_abnormal_olfactory_epithelium1.09705562
45MP0009046_muscle_twitch1.04828097
46MP0008004_abnormal_stomach_pH1.02662710
47MP0005075_abnormal_melanosome_morpholog0.98653278
48MP0008995_early_reproductive_senescence0.97072942
49MP0000465_gastrointestinal_hemorrhage0.96499921
50MP0003878_abnormal_ear_physiology0.95843018
51MP0005377_hearing/vestibular/ear_phenot0.95843018
52MP0001542_abnormal_bone_strength0.95477957
53MP0004742_abnormal_vestibular_system0.92846414
54MP0002006_tumorigenesis0.92456132
55MP0005388_respiratory_system_phenotype0.92366934
56MP0002133_abnormal_respiratory_system0.92366934
57MP0009053_abnormal_anal_canal0.92125611
58MP0005394_taste/olfaction_phenotype0.91286456
59MP0005499_abnormal_olfactory_system0.91286456
60MP0004019_abnormal_vitamin_homeostasis0.88675140
61MP0004782_abnormal_surfactant_physiolog0.88453752
62MP0003191_abnormal_cellular_cholesterol0.86162770
63MP0000537_abnormal_urethra_morphology0.84172465
64MP0004484_altered_response_of0.83946565
65MP0001765_abnormal_ion_homeostasis0.81973601
66MP0003315_abnormal_perineum_morphology0.79764026
67MP0009384_cardiac_valve_regurgitation0.79561148
68MP0001958_emphysema0.79289051
69MP0002877_abnormal_melanocyte_morpholog0.77197991
70MP0002166_altered_tumor_susceptibility0.75915908
71MP0002234_abnormal_pharynx_morphology0.73027418
72MP0005023_abnormal_wound_healing0.71122842
73MP0005076_abnormal_cell_differentiation0.68634866
74MP0005666_abnormal_adipose_tissue0.64649020
75MP0000627_abnormal_mammary_gland0.63655131
76MP0003436_decreased_susceptibility_to0.63609567
77MP0005164_abnormal_response_to0.62700336
78MP0002177_abnormal_outer_ear0.60815936
79MP0001756_abnormal_urination0.59917000
80MP0004885_abnormal_endolymph0.57843440
81MP0002136_abnormal_kidney_physiology0.57146668
82MP0010155_abnormal_intestine_physiology0.56234059
83MP0003763_abnormal_thymus_physiology0.54934782
84MP0005166_decreased_susceptibility_to0.52793633
85MP0001784_abnormal_fluid_regulation0.51907149
86MP0001440_abnormal_grooming_behavior0.51721792
87MP0001502_abnormal_circadian_rhythm0.50772593
88MP0002090_abnormal_vision0.50027094
89MP0002249_abnormal_larynx_morphology0.49932725
90MP0001501_abnormal_sleep_pattern0.49721830
91MP0004272_abnormal_basement_membrane0.48955828
92MP0002233_abnormal_nose_morphology0.48780500
93MP0002282_abnormal_trachea_morphology0.48222290
94MP0003638_abnormal_response/metabolism_0.45304270
95MP0001485_abnormal_pinna_reflex0.44145793
96MP0003828_pulmonary_edema0.44096653
97MP0009643_abnormal_urine_homeostasis0.43089900
98MP0001666_abnormal_nutrient_absorption0.42821633
99MP0010030_abnormal_orbit_morphology0.42700041
100MP0001664_abnormal_digestion0.42266706
101MP0005257_abnormal_intraocular_pressure0.42265836
102MP0002095_abnormal_skin_pigmentation0.40929719
103MP0006138_congestive_heart_failure0.40760778
104MP0004215_abnormal_myocardial_fiber0.38192006
105MP0000538_abnormal_urinary_bladder0.38068798
106MP0002277_abnormal_respiratory_mucosa0.37648245
107MP0002148_abnormal_hypersensitivity_rea0.37523504
108MP0003950_abnormal_plasma_membrane0.37522685
109MP0003786_premature_aging0.36740944
110MP0008569_lethality_at_weaning0.35155937
111MP0002653_abnormal_ependyma_morphology0.34931577
112MP0005508_abnormal_skeleton_morphology0.34916317
113MP0009780_abnormal_chondrocyte_physiolo0.31736013
114MP0000613_abnormal_salivary_gland0.30083793
115MP0005647_abnormal_sex_gland0.29742866
116MP0005375_adipose_tissue_phenotype0.29130188
117MP0003938_abnormal_ear_development0.28372702
118MP0002111_abnormal_tail_morphology0.28197042
119MP0005248_abnormal_Harderian_gland0.27972095
120MP0001853_heart_inflammation0.25512112
121MP0001177_atelectasis0.25367720
122MP0003385_abnormal_body_wall0.25052171
123MP0003755_abnormal_palate_morphology0.24863534
124MP0003136_yellow_coat_color0.24667780
125MP0008875_abnormal_xenobiotic_pharmacok0.24471166
126MP0000470_abnormal_stomach_morphology0.23994644
127MP0005409_darkened_coat_color0.23468664
128MP0010386_abnormal_urinary_bladder0.23461244
129MP0005390_skeleton_phenotype0.22848433
130MP0005085_abnormal_gallbladder_physiolo0.22385974
131MP0005165_increased_susceptibility_to0.22248688
132MP0000013_abnormal_adipose_tissue0.21762645
133MP0000432_abnormal_head_morphology0.21375177
134MP0004264_abnormal_extraembryonic_tissu0.20748392

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.38565084
2Congenital ichthyosiform erythroderma (HP:0007431)8.19368982
3Parakeratosis (HP:0001036)7.88509878
4Hypotrichosis (HP:0001006)6.70967427
5Lip pit (HP:0100267)6.17312466
6Woolly hair (HP:0002224)6.06446444
7Abnormality of the axillary hair (HP:0100134)5.87471598
8Abnormality of secondary sexual hair (HP:0009888)5.87471598
9Erythema (HP:0010783)5.49831029
10Right ventricular cardiomyopathy (HP:0011663)5.34489852
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.33076455
12Palmoplantar hyperkeratosis (HP:0000972)5.29631903
13Plantar hyperkeratosis (HP:0007556)5.18176817
14Chronic bronchitis (HP:0004469)5.11813517
15Palmar hyperkeratosis (HP:0010765)4.92764695
16Erythroderma (HP:0001019)4.81311729
17Hyperactive renin-angiotensin system (HP:0000841)4.51112951
18Abnormality of nail color (HP:0100643)4.49513093
19Oral leukoplakia (HP:0002745)4.31911304
20Abnormal respiratory motile cilium physiology (HP:0012261)4.19372924
21Conjunctival hamartoma (HP:0100780)4.15744668
22Increased IgE level (HP:0003212)4.13491735
23Hypohidrosis (HP:0000966)4.02129967
24Rhinitis (HP:0012384)4.01322822
25Onycholysis (HP:0001806)3.98284516
26Corneal erosion (HP:0200020)3.89028374
27Fragile nails (HP:0001808)3.84929749
28Popliteal pterygium (HP:0009756)3.77980943
29Gangrene (HP:0100758)3.76975623
30Ectropion (HP:0000656)3.74928406
31Abnormal respiratory epithelium morphology (HP:0012253)3.74833898
32Abnormal respiratory motile cilium morphology (HP:0005938)3.74833898
33Abnormal ciliary motility (HP:0012262)3.72783243
34Absent/shortened dynein arms (HP:0200106)3.71100606
35Dynein arm defect of respiratory motile cilia (HP:0012255)3.71100606
36Abnormality of cells of the erythroid lineage (HP:0012130)3.52770104
37Interstitial pulmonary disease (HP:0006530)3.52301421
38Abnormal blistering of the skin (HP:0008066)3.48127250
39Sparse scalp hair (HP:0002209)3.45554755
40Hyporeflexia of lower limbs (HP:0002600)3.33918822
41Pili torti (HP:0003777)3.30846070
42Curly hair (HP:0002212)3.26134230
43Abnormal hemoglobin (HP:0011902)3.24225242
44Pruritus (HP:0000989)3.22884047
45Bronchiectasis (HP:0002110)3.21035317
46Sparse eyelashes (HP:0000653)3.14827143
47Palmoplantar keratoderma (HP:0000982)3.01306684
48Acanthosis nigricans (HP:0000956)2.98847837
49Ventricular tachycardia (HP:0004756)2.91432443
50Abnormal number of erythroid precursors (HP:0012131)2.89942564
51Reticulocytopenia (HP:0001896)2.83612728
52Congenital, generalized hypertrichosis (HP:0004540)2.83441960
53Natal tooth (HP:0000695)2.74386885
54Distal lower limb muscle weakness (HP:0009053)2.73112887
55Abnormality of the salivary glands (HP:0010286)2.70019982
56Severe Myopia (HP:0011003)2.68981440
57Nasal polyposis (HP:0100582)2.68549544
58Thick nail (HP:0001805)2.60245342
59Hyperkalemia (HP:0002153)2.58222878
60Hypoplastic labia majora (HP:0000059)2.57137823
61Advanced eruption of teeth (HP:0006288)2.57009663
62Decreased circulating renin level (HP:0003351)2.56678068
63Bronchitis (HP:0012387)2.55009724
64Septate vagina (HP:0001153)2.54747870
65Nail dystrophy (HP:0008404)2.54178745
66Macrocytic anemia (HP:0001972)2.53913416
67Areflexia of lower limbs (HP:0002522)2.53802126
68Dysmetric saccades (HP:0000641)2.53410135
69Follicular hyperkeratosis (HP:0007502)2.50285639
70Stenosis of the external auditory canal (HP:0000402)2.49005208
71Dysdiadochokinesis (HP:0002075)2.48994956
72Absent eyelashes (HP:0000561)2.48583369
73Abnormality of the dental root (HP:0006486)2.47951149
74Taurodontia (HP:0000679)2.47951149
75Abnormality of permanent molar morphology (HP:0011071)2.47951149
76Renal salt wasting (HP:0000127)2.34660105
77Down-sloping shoulders (HP:0200021)2.34083202
78Abnormality of the dental pulp (HP:0006479)2.32479974
79Abnormality of the labia majora (HP:0012881)2.32025218
80Action tremor (HP:0002345)2.31666036
81Dry skin (HP:0000958)2.31625631
82Abnormality of the nasal mucosa (HP:0000433)2.30874375
83Abnormality of molar morphology (HP:0011070)2.28490852
84Abnormality of molar (HP:0011077)2.28490852
85Milia (HP:0001056)2.26894369
86Furrowed tongue (HP:0000221)2.25200869
87Aplasia cutis congenita (HP:0001057)2.20006277
88Hamartoma of the eye (HP:0010568)2.15379493
89Abnormal hair laboratory examination (HP:0003328)2.15256907
90Hyperaldosteronism (HP:0000859)2.14810818
91Abnormality of the gastric mucosa (HP:0004295)2.13968731
92Pallor (HP:0000980)2.12335427
93Horizontal nystagmus (HP:0000666)2.11090174
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.07817762
95Osteolytic defects of the hand bones (HP:0009699)2.07817762
96Absent hair (HP:0002298)2.07602546
97Lack of skin elasticity (HP:0100679)2.06669512
98Pterygium (HP:0001059)2.03878525
99Abnormality of renin-angiotensin system (HP:0000847)2.03382731
100Anhidrosis (HP:0000970)2.02458337
101Dehydration (HP:0001944)2.01614935
102Hypoparathyroidism (HP:0000829)1.99836523
103Vascular calcification (HP:0004934)1.96893832
104Abnormality of the distal phalanges of the toes (HP:0010182)1.95530523
105Ventricular fibrillation (HP:0001663)1.95415724
106Alopecia of scalp (HP:0002293)1.95280957
107Autoamputation (HP:0001218)1.94334758
108Abnormality of chloride homeostasis (HP:0011422)1.93638316
109Oligodontia (HP:0000677)1.92814374
110Trismus (HP:0000211)1.91927849
111Fasciculations (HP:0002380)1.91326997
112Ridged nail (HP:0001807)1.90586997
113Dry hair (HP:0011359)1.90571198
114Brittle hair (HP:0002299)1.86644966
115Scanning speech (HP:0002168)1.86287311
116Autoimmune hemolytic anemia (HP:0001890)1.84263805
117Cupped ear (HP:0000378)1.83474320
118Aplasia involving bones of the extremities (HP:0009825)1.79562447
119Aplasia involving bones of the upper limbs (HP:0009823)1.79562447
120Aplasia of the phalanges of the hand (HP:0009802)1.79562447
121Concave nail (HP:0001598)1.78605429
122Abnormality of sodium homeostasis (HP:0010931)1.77230737
123Nasolacrimal duct obstruction (HP:0000579)1.76032944
124Hypoplasia of dental enamel (HP:0006297)1.75839046
125Recurrent otitis media (HP:0000403)1.73732691
126Hyperhidrosis (HP:0000975)1.72584798
127Xerostomia (HP:0000217)1.72169419
128Achilles tendon contracture (HP:0001771)1.71290967
129Skin pits (HP:0100276)1.68435337
130Labial hypoplasia (HP:0000066)1.68036427
131Malignant hyperthermia (HP:0002047)1.67337909
132Premature loss of primary teeth (HP:0006323)1.66022853
133Neonatal death (HP:0003811)1.64217264
134Blepharitis (HP:0000498)1.62746747
135Bifid scrotum (HP:0000048)1.60785381
136Abnormality of the Achilles tendon (HP:0005109)1.60230671
137Polygenic inheritance (HP:0010982)1.58750460
138Urticaria (HP:0001025)1.54479628
139Pustule (HP:0200039)1.52979125
140Corneal dystrophy (HP:0001131)1.52179537
141Abnormality of placental membranes (HP:0011409)1.51961775
142Amniotic constriction ring (HP:0009775)1.51961775
143Hypodontia (HP:0000668)1.49586592
144Hypoplastic pelvis (HP:0008839)1.49357079
145Hypoplastic female external genitalia (HP:0012815)1.49355996
146Conical tooth (HP:0000698)1.48925971
147Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.48484996
148Single umbilical artery (HP:0001195)1.48252374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.63413105
2MST1R4.17896845
3MST44.05973652
4MAPKAPK33.95201279
5FER3.47312353
6MAP3K22.99980445
7EPHB22.72983412
8BRSK22.63513514
9NME22.45150427
10PIM22.36972953
11RPS6KB22.33065873
12TRPM72.25986261
13STK242.12488962
14TESK12.01091433
15LRRK21.98023214
16ERBB31.84326932
17PDK21.83043108
18BCR1.76379626
19PIK3CG1.72851660
20TGFBR11.71431487
21STK391.68674990
22ERN11.62185786
23STK101.53092099
24MAP3K141.46070629
25MAPKAPK51.41520387
26GRK71.34626927
27LATS11.29672070
28LIMK11.26903451
29PAK41.22404941
30LMTK21.22237808
31MET1.21256116
32EPHA31.21077438
33TGFBR21.20818495
34MAP3K101.20131795
35WEE11.15474536
36MAP2K61.14554346
37CDK61.13959451
38EPHA41.09722995
39ITK1.08596965
40PTK61.06661784
41CDK191.05576591
42NTRK21.04493698
43DYRK1B1.03716106
44MYLK1.02747339
45TRIM281.02047486
46NEK60.99330227
47TNK20.98267057
48MAP3K120.92338665
49MAP3K90.90475416
50FGFR40.88117145
51CDK30.87912209
52MAP3K110.86542195
53GRK10.86152596
54MAPKAPK20.85794485
55ABL20.84180828
56EIF2AK20.83108301
57SIK30.82800636
58EEF2K0.81945257
59BRSK10.81234324
60MAPK150.81232676
61IRAK30.79649814
62RIPK10.79455746
63TAOK10.79395282
64RIPK40.77923721
65DMPK0.75142135
66GRK50.74953797
67PTK20.74653016
68FGFR20.74430664
69EIF2AK30.74164499
70DDR20.73623851
71MAP3K130.72434462
72PIK3CA0.71697533
73ADRBK10.70251974
74MAP3K10.69759966
75LATS20.69370684
76NME10.68851037
77ILK0.67285875
78OXSR10.66939769
79MAP3K70.66807518
80STK110.66437646
81BLK0.65718804
82MAPK40.61507126
83BMPR20.60281599
84PRKCI0.59773808
85PBK0.59029358
86PRKD10.58728803
87BMPR1B0.58629391
88FGFR30.55283148
89EPHA20.55109792
90PAK30.54908415
91MAP2K40.53784132
92MINK10.50955401
93TTK0.50528523
94BMX0.50515764
95MOS0.50515272
96MAP2K10.49622050
97MAP3K50.49073914
98IKBKB0.48345239
99BCKDK0.46252481
100TSSK60.45340039
101CASK0.45129403
102NEK10.44819708
103FRK0.44442804
104MAPK70.43258248
105FGFR10.41922098
106MAP2K20.41254392
107STK30.39242344
108WNK10.37506473
109PKN10.36956494
110PRKCD0.36439589
111IGF1R0.36435592
112ABL10.36226640
113PRKCE0.36132729
114SCYL20.35141251
115TYRO30.34753741
116AURKA0.34686710
117PRKCA0.34501624
118GSK3A0.34400634
119PDGFRB0.33940095
120RPS6KL10.33822287
121RPS6KC10.33822287
122TLK10.32723686
123TEC0.32219856
124EPHB10.31851635
125YES10.31628601
126RPS6KA20.31462643
127ROCK10.31008506
128RPS6KB10.30784771
129STK38L0.29584971
130STK380.28912669
131WNK40.28726353
132BTK0.27563865
133MAPK120.27353901
134MAP3K60.26559461
135CSNK1D0.26308218
136ERBB40.26014916
137JAK10.25387625
138ACVR1B0.24123417
139SRC0.24094746
140CAMK2G0.21128904
141EGFR0.20788117
142PDPK10.20602101
143CAMK2A0.20563395
144CAMKK20.19555310
145ERBB20.18973771
146PRKG20.17401563
147CSK0.16442333
148ROCK20.15378739

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000625.35706690
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.65310339
3Sphingolipid metabolism_Homo sapiens_hsa006004.58211932
4Ribosome_Homo sapiens_hsa030104.43379347
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.35200473
6Nitrogen metabolism_Homo sapiens_hsa009103.11046708
7Steroid biosynthesis_Homo sapiens_hsa001002.87605731
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69277353
9Circadian rhythm_Homo sapiens_hsa047102.56177668
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.51650744
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.50092702
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.37442236
13Linoleic acid metabolism_Homo sapiens_hsa005912.30767214
14Arachidonic acid metabolism_Homo sapiens_hsa005902.28587495
15Phenylalanine metabolism_Homo sapiens_hsa003602.16493227
16Histidine metabolism_Homo sapiens_hsa003402.08551484
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07572868
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05563408
19Fatty acid metabolism_Homo sapiens_hsa012121.98686613
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96056015
21Chemical carcinogenesis_Homo sapiens_hsa052041.83645885
22Fatty acid biosynthesis_Homo sapiens_hsa000611.53008638
23Taste transduction_Homo sapiens_hsa047421.52781511
24beta-Alanine metabolism_Homo sapiens_hsa004101.46506625
25Sphingolipid signaling pathway_Homo sapiens_hsa040711.38867589
26Fatty acid degradation_Homo sapiens_hsa000711.36586703
27* Retinol metabolism_Homo sapiens_hsa008301.29588780
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28430670
29Ether lipid metabolism_Homo sapiens_hsa005651.27103867
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25886473
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.24168000
32Nicotine addiction_Homo sapiens_hsa050331.20985968
33Renin-angiotensin system_Homo sapiens_hsa046141.20454378
34Tyrosine metabolism_Homo sapiens_hsa003501.16378938
35Glutathione metabolism_Homo sapiens_hsa004801.13194256
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08155736
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01043597
38PPAR signaling pathway_Homo sapiens_hsa033200.99105487
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98515212
40Oxidative phosphorylation_Homo sapiens_hsa001900.95003639
41Long-term potentiation_Homo sapiens_hsa047200.93772610
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.93432272
43Fructose and mannose metabolism_Homo sapiens_hsa000510.93219524
44Axon guidance_Homo sapiens_hsa043600.92434860
45Ovarian steroidogenesis_Homo sapiens_hsa049130.91658423
46Staphylococcus aureus infection_Homo sapiens_hsa051500.89315210
47Serotonergic synapse_Homo sapiens_hsa047260.88357757
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87573120
49p53 signaling pathway_Homo sapiens_hsa041150.84907794
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82690186
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82283791
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81805134
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80731762
54Amphetamine addiction_Homo sapiens_hsa050310.80340665
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76680990
56VEGF signaling pathway_Homo sapiens_hsa043700.76495420
57Estrogen signaling pathway_Homo sapiens_hsa049150.74914790
58Peroxisome_Homo sapiens_hsa041460.74020018
59Amoebiasis_Homo sapiens_hsa051460.73487283
60Renin secretion_Homo sapiens_hsa049240.72380695
61Basal cell carcinoma_Homo sapiens_hsa052170.69122395
62Tight junction_Homo sapiens_hsa045300.68947671
63Vitamin digestion and absorption_Homo sapiens_hsa049770.68470589
64ABC transporters_Homo sapiens_hsa020100.67991818
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66993106
66GABAergic synapse_Homo sapiens_hsa047270.65434273
67Alzheimers disease_Homo sapiens_hsa050100.64748583
68Circadian entrainment_Homo sapiens_hsa047130.64229907
69Long-term depression_Homo sapiens_hsa047300.63455336
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62879357
71Adherens junction_Homo sapiens_hsa045200.60714520
72Fat digestion and absorption_Homo sapiens_hsa049750.60008683
73Bladder cancer_Homo sapiens_hsa052190.59747714
74Calcium signaling pathway_Homo sapiens_hsa040200.59255668
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58885266
76Choline metabolism in cancer_Homo sapiens_hsa052310.58486144
77GnRH signaling pathway_Homo sapiens_hsa049120.56895727
78Pancreatic secretion_Homo sapiens_hsa049720.56019751
79Endocytosis_Homo sapiens_hsa041440.55704571
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55076923
81Lysosome_Homo sapiens_hsa041420.54944380
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54796191
83Mineral absorption_Homo sapiens_hsa049780.53922967
84Dopaminergic synapse_Homo sapiens_hsa047280.52422817
85Arginine biosynthesis_Homo sapiens_hsa002200.51516791
86Arginine and proline metabolism_Homo sapiens_hsa003300.51071124
87Huntingtons disease_Homo sapiens_hsa050160.51032214
88Propanoate metabolism_Homo sapiens_hsa006400.50592141
89ECM-receptor interaction_Homo sapiens_hsa045120.49543533
90Caffeine metabolism_Homo sapiens_hsa002320.49427083
91Phototransduction_Homo sapiens_hsa047440.48898687
92Pertussis_Homo sapiens_hsa051330.47444548
93Pentose phosphate pathway_Homo sapiens_hsa000300.46566894
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46212880
95Hippo signaling pathway_Homo sapiens_hsa043900.45999264
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45563953
97Proteasome_Homo sapiens_hsa030500.45521967
98Glycerolipid metabolism_Homo sapiens_hsa005610.44102215
99Melanogenesis_Homo sapiens_hsa049160.42871586
100Vibrio cholerae infection_Homo sapiens_hsa051100.42315978
101Dorso-ventral axis formation_Homo sapiens_hsa043200.40463750
102Thyroid cancer_Homo sapiens_hsa052160.40002421
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39833962
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39602695
105Morphine addiction_Homo sapiens_hsa050320.39566907
106Complement and coagulation cascades_Homo sapiens_hsa046100.39057238
107Protein digestion and absorption_Homo sapiens_hsa049740.38334755
108Platelet activation_Homo sapiens_hsa046110.37866661
109Proteoglycans in cancer_Homo sapiens_hsa052050.37234914
110Ras signaling pathway_Homo sapiens_hsa040140.37213810
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35320183
112Folate biosynthesis_Homo sapiens_hsa007900.34752840
113Phagosome_Homo sapiens_hsa041450.34357957
114Gap junction_Homo sapiens_hsa045400.34136679
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34043994
116Gastric acid secretion_Homo sapiens_hsa049710.33541143
117Starch and sucrose metabolism_Homo sapiens_hsa005000.33316071
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33085016
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32926290
120Hepatitis C_Homo sapiens_hsa051600.32330417
121Collecting duct acid secretion_Homo sapiens_hsa049660.32049360
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31605491
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31383719
124Bile secretion_Homo sapiens_hsa049760.31159743
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.30814798
126Sulfur metabolism_Homo sapiens_hsa009200.30779083
127Butanoate metabolism_Homo sapiens_hsa006500.30373261
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30336917
129ErbB signaling pathway_Homo sapiens_hsa040120.30246057
130Parkinsons disease_Homo sapiens_hsa050120.29918606
131Salivary secretion_Homo sapiens_hsa049700.28334985
132TGF-beta signaling pathway_Homo sapiens_hsa043500.27079428
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.26209996
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.25068181
135MicroRNAs in cancer_Homo sapiens_hsa052060.22418239
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21177344
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.20380863
138Cardiac muscle contraction_Homo sapiens_hsa042600.19227491
139Metabolic pathways_Homo sapiens_hsa011000.18004719
140Tryptophan metabolism_Homo sapiens_hsa003800.17856032
141Glutamatergic synapse_Homo sapiens_hsa047240.13963913
142Toxoplasmosis_Homo sapiens_hsa051450.13034484
143Legionellosis_Homo sapiens_hsa051340.12519353

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