SDR39U1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) superfamily, which includes both classical and extended types. The encoded protein represents an extended type, with similarity to epimerases. Alternatively spliced transcript variants that encode different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NADH metabolic process (GO:0006734)6.23923723
2tricarboxylic acid cycle (GO:0006099)6.16300224
3oxaloacetate metabolic process (GO:0006107)5.30198204
4succinate metabolic process (GO:0006105)5.21854190
5regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.90939270
6regulation of acyl-CoA biosynthetic process (GO:0050812)4.81857941
7regulation of coenzyme metabolic process (GO:0051196)4.45905920
8regulation of cofactor metabolic process (GO:0051193)4.45905920
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.24505730
10oxidative phosphorylation (GO:0006119)4.19473945
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.11054543
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.01888278
13regulation of oxidative phosphorylation (GO:0002082)3.94644712
14pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.94348532
15metallo-sulfur cluster assembly (GO:0031163)3.89491978
16iron-sulfur cluster assembly (GO:0016226)3.89491978
17ubiquinone biosynthetic process (GO:0006744)3.88228336
18respiratory electron transport chain (GO:0022904)3.87522201
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.82785962
20electron transport chain (GO:0022900)3.81967361
21chaperone-mediated protein transport (GO:0072321)3.78262866
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.77245523
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.77245523
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72623318
25ribosomal small subunit assembly (GO:0000028)3.70523879
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.67853010
27synaptic vesicle exocytosis (GO:0016079)3.62795766
28COPI coating of Golgi vesicle (GO:0048205)3.62395892
29Golgi transport vesicle coating (GO:0048200)3.62395892
30lactate metabolic process (GO:0006089)3.54877104
31ubiquinone metabolic process (GO:0006743)3.53035361
322-oxoglutarate metabolic process (GO:0006103)3.47540188
33detection of calcium ion (GO:0005513)3.47421481
34pyrimidine nucleotide catabolic process (GO:0006244)3.45860776
35viral transcription (GO:0019083)3.42556861
36regulation of cell communication by electrical coupling (GO:0010649)3.42307026
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.41504100
38ATP synthesis coupled proton transport (GO:0015986)3.41504100
39inner mitochondrial membrane organization (GO:0007007)3.39548218
40protein neddylation (GO:0045116)3.38961896
41DNA strand renaturation (GO:0000733)3.38368317
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37909161
43regulation of mitochondrial translation (GO:0070129)3.37611678
44inositol phosphate catabolic process (GO:0071545)3.37044753
45regulation of sulfur metabolic process (GO:0042762)3.36523856
46regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.35776500
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.32984773
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31486535
49DNA deamination (GO:0045006)3.29312627
50quinone biosynthetic process (GO:1901663)3.27266135
51regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.26899987
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26720133
53base-excision repair, AP site formation (GO:0006285)3.26645528
54protein complex biogenesis (GO:0070271)3.25992027
55tricarboxylic acid metabolic process (GO:0072350)3.21559362
56regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19872260
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15213490
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.14729860
59deoxyribonucleotide catabolic process (GO:0009264)3.14664733
60translational termination (GO:0006415)3.14426817
61activation of protein kinase A activity (GO:0034199)3.14140492
62regulation of relaxation of muscle (GO:1901077)3.13464418
63striatum development (GO:0021756)3.12333380
64protein polyglutamylation (GO:0018095)3.10689212
65regulation of synaptic vesicle exocytosis (GO:2000300)3.10619212
66energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10109545
67ATP hydrolysis coupled proton transport (GO:0015991)3.10109545
68sarcomere organization (GO:0045214)3.08348400
69GPI anchor biosynthetic process (GO:0006506)3.08304514
70regulation of synaptic vesicle transport (GO:1902803)3.06118932
71gluconeogenesis (GO:0006094)3.05709786
72oxygen transport (GO:0015671)3.03256560
73mannosylation (GO:0097502)3.03161243
74water-soluble vitamin biosynthetic process (GO:0042364)3.02526100
75valine metabolic process (GO:0006573)3.01141954
76preassembly of GPI anchor in ER membrane (GO:0016254)3.01094134
77purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.00274361
78hydrogen ion transmembrane transport (GO:1902600)2.98868461
79cytochrome complex assembly (GO:0017004)2.98617998
80purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97943224
81purine deoxyribonucleotide metabolic process (GO:0009151)2.97906785
82GTP biosynthetic process (GO:0006183)2.97773304
83purine nucleoside triphosphate biosynthetic process (GO:0009145)2.97505219
84GPI anchor metabolic process (GO:0006505)2.96434798
85mitochondrial respiratory chain complex assembly (GO:0033108)2.94430795
86translational elongation (GO:0006414)2.94371975
87hexose biosynthetic process (GO:0019319)2.93387212
88purine deoxyribonucleotide catabolic process (GO:0009155)2.92501754
89glutamate secretion (GO:0014047)2.92286685
90aerobic respiration (GO:0009060)2.92274064
91deoxyribose phosphate catabolic process (GO:0046386)2.91878679
92platelet dense granule organization (GO:0060155)2.91138396
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90621870
94positive regulation of mitochondrial fission (GO:0090141)2.90156801
95aldehyde catabolic process (GO:0046185)2.89790728
96synaptic vesicle maturation (GO:0016188)2.88816839
97C-terminal protein lipidation (GO:0006501)2.88692984
98neurotransmitter secretion (GO:0007269)2.88085715
99pyrimidine nucleobase catabolic process (GO:0006208)2.86958671
100behavioral response to nicotine (GO:0035095)2.86795234
101purine nucleotide salvage (GO:0032261)2.86732247
102lysine metabolic process (GO:0006553)2.85648288
103lysine catabolic process (GO:0006554)2.85648288
104cotranslational protein targeting to membrane (GO:0006613)2.84699394
105sequestering of actin monomers (GO:0042989)2.84155970
106respiratory chain complex IV assembly (GO:0008535)2.82443628
107proton transport (GO:0015992)2.82348152
108cardiac muscle contraction (GO:0060048)2.81795931
109galactose catabolic process (GO:0019388)2.81225317
110protein targeting to ER (GO:0045047)2.80912549
111hydrogen transport (GO:0006818)2.80115270
1122-deoxyribonucleotide metabolic process (GO:0009394)2.79797016
113inositol phosphate dephosphorylation (GO:0046855)2.78716695
114phosphorylated carbohydrate dephosphorylation (GO:0046838)2.78716695
115pyrimidine ribonucleoside catabolic process (GO:0046133)2.77927144
116neuronal action potential propagation (GO:0019227)2.76467450
117axoneme assembly (GO:0035082)2.76077229
118transferrin transport (GO:0033572)2.74264651
119positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.72643783
120protein localization to endoplasmic reticulum (GO:0070972)2.72342385
121sarcoplasmic reticulum calcium ion transport (GO:0070296)2.72156970
122regulation of synapse structural plasticity (GO:0051823)2.72086102
123ATP biosynthetic process (GO:0006754)2.71970352
124regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70035877
125deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69715348
126negative regulation of calcium ion transmembrane transport (GO:1903170)2.69697931
127negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.69697931
128response to ischemia (GO:0002931)2.68953332
129negative regulation of cation channel activity (GO:2001258)2.67507369
130adaptation of signaling pathway (GO:0023058)2.66425552
131regulation of cilium movement (GO:0003352)2.66109546
132positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.66103198
133establishment of protein localization to endoplasmic reticulum (GO:0072599)2.65593968
134regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.64048670
135branched-chain amino acid metabolic process (GO:0009081)2.62897596
136cell communication by electrical coupling (GO:0010644)2.61766576
137negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.61547710
138establishment of protein localization to mitochondrion (GO:0072655)2.61506996
139vocalization behavior (GO:0071625)2.60091211
140cardiac conduction (GO:0061337)2.59857198
141positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.59460069
142mitochondrial respiratory chain complex I assembly (GO:0032981)2.59416632
143NADH dehydrogenase complex assembly (GO:0010257)2.59416632
144mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59416632
145regulation of calcium ion transmembrane transporter activity (GO:1901019)2.59107260
146regulation of calcium ion transmembrane transport (GO:1903169)2.59107260
147L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57875432
148negative regulation of cAMP-mediated signaling (GO:0043951)2.57731376
149intracellular protein transmembrane import (GO:0044743)2.57666809
150pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.57508070
151regulation of membrane repolarization (GO:0060306)2.57298178
152protein targeting to mitochondrion (GO:0006626)2.57051200
153proteasome assembly (GO:0043248)2.56978810
154epithelial cilium movement (GO:0003351)2.56192540
155aspartate family amino acid catabolic process (GO:0009068)2.55471367
156positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.55280556
157cellular response to interferon-beta (GO:0035458)2.55222450
158heart process (GO:0003015)2.55010454
159heart contraction (GO:0060047)2.55010454
160ferric iron transport (GO:0015682)2.54730158
161trivalent inorganic cation transport (GO:0072512)2.54730158
162cell communication involved in cardiac conduction (GO:0086065)2.54269583
163establishment of mitochondrion localization (GO:0051654)2.54258847
164branched-chain amino acid catabolic process (GO:0009083)2.54039017
165ribonucleoside triphosphate biosynthetic process (GO:0009201)2.53991891
166deoxyribose phosphate metabolic process (GO:0019692)2.53951752
167protein-cofactor linkage (GO:0018065)2.52427774
168lysosome localization (GO:0032418)2.52184812
169negative regulation of telomere maintenance (GO:0032205)2.51823746
170C-terminal protein amino acid modification (GO:0018410)2.50574884
171negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50475831
172catecholamine transport (GO:0051937)2.50405076
173phosphatidylglycerol biosynthetic process (GO:0006655)2.48933858
174adenosine metabolic process (GO:0046085)2.48411165
175viral life cycle (GO:0019058)2.48405063
176negative regulation of B cell apoptotic process (GO:0002903)2.47328202
177monosaccharide biosynthetic process (GO:0046364)2.46366199
178nonmotile primary cilium assembly (GO:0035058)2.46102481
179membrane depolarization during action potential (GO:0086010)2.46069136
180cellular component biogenesis (GO:0044085)2.45220575
181guanosine-containing compound biosynthetic process (GO:1901070)2.43983531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.47342002
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.13457293
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13221238
4EZH2_22144423_ChIP-Seq_EOC_Human3.08886044
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95488131
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.86314498
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.84800000
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.71580442
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.65183376
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54452425
11GATA1_22025678_ChIP-Seq_K562_Human2.31629902
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25976182
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14719785
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.13709284
15VDR_23849224_ChIP-Seq_CD4+_Human2.08302548
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04622824
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.04279299
18GBX2_23144817_ChIP-Seq_PC3_Human2.00812593
19REST_21632747_ChIP-Seq_MESCs_Mouse1.98746183
20RARB_27405468_Chip-Seq_BRAIN_Mouse1.88234354
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85089263
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84799494
23SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.81416310
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77689868
25SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.77658121
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76741594
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75499283
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73550837
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73366942
30FOXP3_21729870_ChIP-Seq_TREG_Human1.71244335
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70619691
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66619628
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65462396
34DROSHA_22980978_ChIP-Seq_HELA_Human1.62208298
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60879953
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60138793
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59532821
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58197759
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53196737
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51259350
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49178964
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49171116
43XRN2_22483619_ChIP-Seq_HELA_Human1.47956298
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47466517
45CIITA_25753668_ChIP-Seq_RAJI_Human1.46887761
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46762674
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41475984
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40204880
49ZNF263_19887448_ChIP-Seq_K562_Human1.39590795
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39277640
51MYC_18940864_ChIP-ChIP_HL60_Human1.37565876
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.37508349
53TAF15_26573619_Chip-Seq_HEK293_Human1.34413871
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32158598
55E2F1_20622854_ChIP-Seq_HELA_Human1.31061816
56ERA_21632823_ChIP-Seq_H3396_Human1.30654116
57ZNF274_21170338_ChIP-Seq_K562_Hela1.28781494
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28589445
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27460566
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26484801
61CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26403558
62* FOXP1_21924763_ChIP-Seq_HESCs_Human1.25126786
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24896975
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.24308712
65TTF2_22483619_ChIP-Seq_HELA_Human1.24225230
66TP53_22573176_ChIP-Seq_HFKS_Human1.24181440
67PHF8_20622854_ChIP-Seq_HELA_Human1.23780115
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23692672
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23586944
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.21850795
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21050321
72BCL6_27268052_Chip-Seq_Bcells_Human1.17938049
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17793427
74NANOG_20526341_ChIP-Seq_ESCs_Human1.16847046
75TAF2_19829295_ChIP-Seq_ESCs_Human1.15760481
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.15026699
77CTCF_20526341_ChIP-Seq_ESCs_Human1.14544790
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14125831
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14076129
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12839305
81NCOR_22424771_ChIP-Seq_293T_Human1.12517255
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12354793
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12217139
84P300_27268052_Chip-Seq_Bcells_Human1.11879447
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11443800
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11019353
87OCT4_20526341_ChIP-Seq_ESCs_Human1.10130530
88SA1_27219007_Chip-Seq_Bcells_Human1.09881362
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09394436
90CTCF_26484167_Chip-Seq_Bcells_Mouse1.08176105
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.07197148
92IGF1R_20145208_ChIP-Seq_DFB_Human1.07123159
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06645336
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.05158976
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04978935
96* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04003879
97BCOR_27268052_Chip-Seq_Bcells_Human1.03005493
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00434386
99KDM5A_27292631_Chip-Seq_BREAST_Human0.98515420
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98207249
101* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97847070
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97769505
103RARB_24833708_ChIP-Seq_LIVER_Mouse0.97628585
104EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97436920
105DCP1A_22483619_ChIP-Seq_HELA_Human0.97430154
106IRF1_19129219_ChIP-ChIP_H3396_Human0.97322901
107GABP_17652178_ChIP-ChIP_JURKAT_Human0.97128826
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96324891
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.96029942
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95594835
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95372940
112SMC4_20622854_ChIP-Seq_HELA_Human0.95282886
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94958774
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94399215
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94210349
116LXR_22292898_ChIP-Seq_THP-1_Human0.93854982
117E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92251023
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92202434
119SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91949303
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91751782
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91269395
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90803984
123CTCF_27219007_Chip-Seq_Bcells_Human0.90790634
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90738917
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90554909
126SOX2_21211035_ChIP-Seq_LN229_Human0.90087964
127BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89962580
128ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89714616
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89712527
130RAC3_21632823_ChIP-Seq_H3396_Human0.89663381
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86631985
132EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86178956
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86106599
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85501991
135JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85249043
136P68_20966046_ChIP-Seq_HELA_Human0.85186310
137ERG_20517297_ChIP-Seq_VCAP_Human0.84749082
138GABP_19822575_ChIP-Seq_HepG2_Human0.84107787
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83874936
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82221651
141SMAD4_21799915_ChIP-Seq_A2780_Human0.81980391
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81097961
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.80745624
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.80745624
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.79532362
146AR_25329375_ChIP-Seq_VCAP_Human0.79465287
147* ETS1_20019798_ChIP-Seq_JURKAT_Human0.79416527
148RUNX_20019798_ChIP-Seq_JUKART_Human0.78168229
149SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77404954
150IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.76081673
151CBP_20019798_ChIP-Seq_JUKART_Human0.76081673
152MYC_22102868_ChIP-Seq_BL_Human0.75646728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.93375295
2MP0003646_muscle_fatigue3.94037851
3MP0002909_abnormal_adrenal_gland2.94113710
4MP0002653_abnormal_ependyma_morphology2.89381348
5MP0000751_myopathy2.83520029
6MP0002102_abnormal_ear_morphology2.77050983
7MP0004036_abnormal_muscle_relaxation2.63615828
8MP0004043_abnormal_pH_regulation2.58966705
9MP0004084_abnormal_cardiac_muscle2.56242178
10MP0006292_abnormal_olfactory_placode2.49002987
11MP0004215_abnormal_myocardial_fiber2.40289125
12MP0006036_abnormal_mitochondrial_physio2.38198520
13MP0004859_abnormal_synaptic_plasticity2.31449548
14MP0002822_catalepsy2.28854228
15MP0000749_muscle_degeneration2.25635807
16MP0000013_abnormal_adipose_tissue2.22825881
17MP0003635_abnormal_synaptic_transmissio2.09427352
18MP0002876_abnormal_thyroid_physiology2.04793931
19MP0003011_delayed_dark_adaptation1.95605741
20MP0004145_abnormal_muscle_electrophysio1.94109845
21MP0001984_abnormal_olfaction1.92400501
22MP0006072_abnormal_retinal_apoptosis1.88297946
23MP0009745_abnormal_behavioral_response1.87325459
24MP0003878_abnormal_ear_physiology1.86336281
25MP0005377_hearing/vestibular/ear_phenot1.86336281
26MP0005551_abnormal_eye_electrophysiolog1.85720198
27MP0005075_abnormal_melanosome_morpholog1.78814665
28MP0003879_abnormal_hair_cell1.77547925
29MP0003880_abnormal_central_pattern1.73047582
30MP0010386_abnormal_urinary_bladder1.71600661
31MP0003183_abnormal_peptide_metabolism1.71037179
32MP0001968_abnormal_touch/_nociception1.70570467
33MP0001486_abnormal_startle_reflex1.69041730
34MP0002064_seizures1.68769451
35MP0005646_abnormal_pituitary_gland1.68175690
36MP0008789_abnormal_olfactory_epithelium1.67211515
37MP0009046_muscle_twitch1.66323623
38MP0002735_abnormal_chemical_nociception1.59693531
39MP0002736_abnormal_nociception_after1.56877940
40MP0002272_abnormal_nervous_system1.55472250
41MP0004130_abnormal_muscle_cell1.55322615
42MP0005394_taste/olfaction_phenotype1.53285940
43MP0005499_abnormal_olfactory_system1.53285940
44MP0006035_abnormal_mitochondrial_morpho1.52728085
45MP0001835_abnormal_antigen_presentation1.51497377
46MP0002063_abnormal_learning/memory/cond1.49951322
47MP0004484_altered_response_of1.48520229
48MP0005535_abnormal_body_temperature1.48392906
49MP0003122_maternal_imprinting1.45649745
50MP0005620_abnormal_muscle_contractility1.43873321
51MP0005330_cardiomyopathy1.43483154
52MP0001501_abnormal_sleep_pattern1.41652772
53MP0004270_analgesia1.40485213
54MP0000372_irregular_coat_pigmentation1.38926097
55MP0002972_abnormal_cardiac_muscle1.36849707
56MP0002572_abnormal_emotion/affect_behav1.36721418
57MP0008569_lethality_at_weaning1.35903353
58MP0002734_abnormal_mechanical_nocicepti1.34333070
59MP0006276_abnormal_autonomic_nervous1.33632928
60MP0001529_abnormal_vocalization1.33300576
61MP0000747_muscle_weakness1.33239519
62MP0005253_abnormal_eye_physiology1.30297813
63MP0001485_abnormal_pinna_reflex1.30268496
64MP0009780_abnormal_chondrocyte_physiolo1.30017073
65MP0004742_abnormal_vestibular_system1.29360876
66MP0002106_abnormal_muscle_physiology1.28694411
67MP0004133_heterotaxia1.27878536
68MP0008961_abnormal_basal_metabolism1.27650012
69MP0002067_abnormal_sensory_capabilities1.27214588
70MP0002877_abnormal_melanocyte_morpholog1.26393759
71MP0004085_abnormal_heartbeat1.26261467
72MP0001764_abnormal_homeostasis1.25858246
73MP0004147_increased_porphyrin_level1.25615423
74MP0002078_abnormal_glucose_homeostasis1.25185009
75MP0008995_early_reproductive_senescence1.24977040
76MP0001765_abnormal_ion_homeostasis1.24778877
77MP0001986_abnormal_taste_sensitivity1.24323867
78MP0005423_abnormal_somatic_nervous1.22343317
79MP0003121_genomic_imprinting1.21668668
80MP0008877_abnormal_DNA_methylation1.21094274
81MP0003137_abnormal_impulse_conducting1.19743078
82MP0002693_abnormal_pancreas_physiology1.19311353
83MP0004924_abnormal_behavior1.18525330
84MP0005386_behavior/neurological_phenoty1.18525330
85MP0002638_abnormal_pupillary_reflex1.17211310
86MP0002269_muscular_atrophy1.16820875
87MP0008058_abnormal_DNA_repair1.16292847
88MP0002928_abnormal_bile_duct1.16211205
89MP0005385_cardiovascular_system_phenoty1.13621686
90MP0001544_abnormal_cardiovascular_syste1.13621686
91MP0001502_abnormal_circadian_rhythm1.12401648
92MP0008872_abnormal_physiological_respon1.11635688
93MP0004087_abnormal_muscle_fiber1.10234154
94MP0003866_abnormal_defecation1.08983652
95MP0003136_yellow_coat_color1.08397058
96MP0000230_abnormal_systemic_arterial1.07943671
97MP0005645_abnormal_hypothalamus_physiol1.07894423
98MP0005084_abnormal_gallbladder_morpholo1.07862840
99MP0001970_abnormal_pain_threshold1.06494014
100MP0004233_abnormal_muscle_weight1.06393358
101MP0001905_abnormal_dopamine_level1.06260236
102MP0001664_abnormal_digestion1.03892714
103MP0002163_abnormal_gland_morphology1.01332783
104MP0005332_abnormal_amino_acid1.01301406
105MP0003186_abnormal_redox_activity1.01271770
106MP0002733_abnormal_thermal_nociception1.01068613
107MP0005636_abnormal_mineral_homeostasis0.98415565
108MP0005369_muscle_phenotype0.98018538
109MP0001756_abnormal_urination0.96024010
110MP0004510_myositis0.95508174
111MP0002138_abnormal_hepatobiliary_system0.95237131
112MP0006138_congestive_heart_failure0.95074571
113MP0000759_abnormal_skeletal_muscle0.94608326
114MP0001963_abnormal_hearing_physiology0.93084421
115MP0002557_abnormal_social/conspecific_i0.92500905
116MP0000631_abnormal_neuroendocrine_gland0.91183162
117MP0003787_abnormal_imprinting0.90594550
118MP0000026_abnormal_inner_ear0.88544674
119MP0008775_abnormal_heart_ventricle0.88403806
120MP0009379_abnormal_foot_pigmentation0.87230278
121MP0004885_abnormal_endolymph0.87194764
122MP0003763_abnormal_thymus_physiology0.87099585
123MP0001944_abnormal_pancreas_morphology0.85957578
124MP0009643_abnormal_urine_homeostasis0.84617995
125MP0003953_abnormal_hormone_level0.83615546
126MP0008875_abnormal_xenobiotic_pharmacok0.83598164
127MP0001800_abnormal_humoral_immune0.83478540
128MP0002752_abnormal_somatic_nervous0.83220611
129MP0002938_white_spotting0.81500558
130MP0004811_abnormal_neuron_physiology0.81148846
131MP0002160_abnormal_reproductive_system0.80821273
132MP0003195_calcinosis0.78141954
133MP0005360_urolithiasis0.77947397
134MP0002229_neurodegeneration0.77820504
135MP0002277_abnormal_respiratory_mucosa0.77442300
136MP0000681_abnormal_thyroid_gland0.77436970
137MP0002127_abnormal_cardiovascular_syste0.76758204
138MP0005671_abnormal_response_to0.76669174
139MP0004142_abnormal_muscle_tone0.76380505
140MP0001440_abnormal_grooming_behavior0.76104390
141MP0000538_abnormal_urinary_bladder0.75886724
142MP0005670_abnormal_white_adipose0.75687975
143MP0005379_endocrine/exocrine_gland_phen0.73985421
144MP0000685_abnormal_immune_system0.72385697
145MP0003252_abnormal_bile_duct0.71622443
146MP0000955_abnormal_spinal_cord0.70303140
147MP0002069_abnormal_eating/drinking_beha0.68841722
148MP0005389_reproductive_system_phenotype0.68597848
149MP0002184_abnormal_innervation0.67632248

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)4.20839697
2Acute necrotizing encephalopathy (HP:0006965)4.03522830
3Exercise-induced myalgia (HP:0003738)3.99197179
4Hepatic necrosis (HP:0002605)3.97514876
5Hepatocellular necrosis (HP:0001404)3.93509707
6Elevated erythrocyte sedimentation rate (HP:0003565)3.90749857
7Focal motor seizures (HP:0011153)3.77795580
8Myoglobinuria (HP:0002913)3.68123706
9Mitochondrial inheritance (HP:0001427)3.67615109
10Visual hallucinations (HP:0002367)3.56722099
11Acute encephalopathy (HP:0006846)3.51334933
12Gout (HP:0001997)3.47089724
13Palpitations (HP:0001962)3.44032007
14Pheochromocytoma (HP:0002666)3.42643840
15Progressive macrocephaly (HP:0004481)3.41061429
16Increased CSF lactate (HP:0002490)3.39820816
17Neuroendocrine neoplasm (HP:0100634)3.33297379
18Calf muscle hypertrophy (HP:0008981)3.27578127
19Lactic acidosis (HP:0003128)3.17484038
20Oligomenorrhea (HP:0000876)3.05637278
21Ketoacidosis (HP:0001993)3.05008315
22Muscle hypertrophy of the lower extremities (HP:0008968)3.03620124
23Lipid accumulation in hepatocytes (HP:0006561)3.02471611
24Increased hepatocellular lipid droplets (HP:0006565)3.02277222
25Renal Fanconi syndrome (HP:0001994)3.01173672
26Sudden death (HP:0001699)2.97703549
27Exercise-induced muscle cramps (HP:0003710)2.96866859
28Medial flaring of the eyebrow (HP:0010747)2.92505885
29Molar tooth sign on MRI (HP:0002419)2.87705970
30Abnormality of midbrain morphology (HP:0002418)2.87705970
31Muscle fiber atrophy (HP:0100295)2.83525392
32Increased muscle lipid content (HP:0009058)2.82272064
33Exercise intolerance (HP:0003546)2.75992663
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.69656107
35Abnormality of alanine metabolism (HP:0010916)2.68658025
36Hyperalaninemia (HP:0003348)2.68658025
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68658025
38Increased intramyocellular lipid droplets (HP:0012240)2.68232521
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66715183
403-Methylglutaconic aciduria (HP:0003535)2.65947395
41Abnormality of fatty-acid metabolism (HP:0004359)2.63663762
42Rhabdomyolysis (HP:0003201)2.62961848
43Pancreatic fibrosis (HP:0100732)2.58271296
44True hermaphroditism (HP:0010459)2.57449681
45Cerebral edema (HP:0002181)2.56926270
46Pancreatic cysts (HP:0001737)2.55965843
47Nephronophthisis (HP:0000090)2.52499789
48Generalized aminoaciduria (HP:0002909)2.51812966
49Gait imbalance (HP:0002141)2.50457904
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49429841
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49429841
52Polyphagia (HP:0002591)2.48390913
53Neoplasm of the adrenal gland (HP:0100631)2.48166327
54Ragged-red muscle fibers (HP:0003200)2.47015175
55Hyperglycinemia (HP:0002154)2.46086470
56Chronic otitis media (HP:0000389)2.41909719
57Congenital primary aphakia (HP:0007707)2.41570383
58Increased serum lactate (HP:0002151)2.41554853
59Abnormal number of erythroid precursors (HP:0012131)2.41143665
60Febrile seizures (HP:0002373)2.40203252
61Syncope (HP:0001279)2.39544766
62Methylmalonic aciduria (HP:0012120)2.39351487
63Myotonia (HP:0002486)2.38847796
64Abolished electroretinogram (ERG) (HP:0000550)2.38268802
65Atonic seizures (HP:0010819)2.37212676
66Ventricular fibrillation (HP:0001663)2.37134023
67Atrial fibrillation (HP:0005110)2.33940255
68Chronic sinusitis (HP:0011109)2.33899559
69Ketosis (HP:0001946)2.33226267
70Progressive muscle weakness (HP:0003323)2.33084195
71Congenital stationary night blindness (HP:0007642)2.32762006
72Rib fusion (HP:0000902)2.32730641
73Nephrogenic diabetes insipidus (HP:0009806)2.31243852
74Absence seizures (HP:0002121)2.30864784
75Respiratory failure (HP:0002878)2.30477595
76Asymmetric septal hypertrophy (HP:0001670)2.28223982
77Bundle branch block (HP:0011710)2.27826035
78Prolonged QT interval (HP:0001657)2.26808303
79Tinnitus (HP:0000360)2.26633202
80Methylmalonic acidemia (HP:0002912)2.26465515
81Hypoglycemic coma (HP:0001325)2.26432186
82Severe combined immunodeficiency (HP:0004430)2.26421506
83Progressive microcephaly (HP:0000253)2.26020592
84Dicarboxylic aciduria (HP:0003215)2.25956944
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25956944
86Supraventricular tachycardia (HP:0004755)2.25823420
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25303528
88Primary atrial arrhythmia (HP:0001692)2.24360489
89Panhypogammaglobulinemia (HP:0003139)2.23626832
90Abnormality of the calf musculature (HP:0001430)2.23376442
91Exertional dyspnea (HP:0002875)2.22163927
92Epileptic encephalopathy (HP:0200134)2.20215076
93Hypothermia (HP:0002045)2.19657824
94Abnormality of cells of the erythroid lineage (HP:0012130)2.18632180
95Esophageal neoplasm (HP:0100751)2.18091029
96Neoplasm of head and neck (HP:0012288)2.18091029
97CNS demyelination (HP:0007305)2.16997464
98Decreased circulating renin level (HP:0003351)2.16129063
99Hyperventilation (HP:0002883)2.15091356
100Supraventricular arrhythmia (HP:0005115)2.15004724
101Failure to thrive in infancy (HP:0001531)2.14587017
102Menstrual irregularities (HP:0000858)2.14066664
103Conjunctival hamartoma (HP:0100780)2.12997935
104Abnormality of the left ventricular outflow tract (HP:0011103)2.11923579
105Subaortic stenosis (HP:0001682)2.11923579
106Hyperuricemia (HP:0002149)2.10923148
107Increased purine levels (HP:0004368)2.10923148
108Abnormality of glycine metabolism (HP:0010895)2.10675928
109Abnormality of serine family amino acid metabolism (HP:0010894)2.10675928
110Reticulocytopenia (HP:0001896)2.09452377
111Ventricular tachycardia (HP:0004756)2.08850369
112Left ventricular hypertrophy (HP:0001712)2.08456769
113Anxiety (HP:0000739)2.06001564
114Abnormal rod and cone electroretinograms (HP:0008323)2.05559203
115Hyperactive renin-angiotensin system (HP:0000841)2.05485288
116Abnormal EKG (HP:0003115)2.04426915
117Dilated cardiomyopathy (HP:0001644)2.03809787
118Emotional lability (HP:0000712)2.02858665
119Poor suck (HP:0002033)2.01127984
120Glycosuria (HP:0003076)1.99994893
121Abnormality of urine glucose concentration (HP:0011016)1.99994893
122Unsteady gait (HP:0002317)1.99975210
123Muscle stiffness (HP:0003552)1.98537159
124Hyperglycinuria (HP:0003108)1.97539518
125Retinal dysplasia (HP:0007973)1.96936662
126Abnormality of the renal medulla (HP:0100957)1.96836522
127Myokymia (HP:0002411)1.95370618
128Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94715657
129Respiratory difficulties (HP:0002880)1.94071539
130Centrally nucleated skeletal muscle fibers (HP:0003687)1.93545038
131Dysmetric saccades (HP:0000641)1.93392869
132Rimmed vacuoles (HP:0003805)1.93222561
133Central scotoma (HP:0000603)1.92940132
134Lethargy (HP:0001254)1.92480959
135Severe visual impairment (HP:0001141)1.91562578
136Optic disc pallor (HP:0000543)1.91376411
137Delayed CNS myelination (HP:0002188)1.91174383
138Abnormality of glycolysis (HP:0004366)1.91154064
139Increased serum pyruvate (HP:0003542)1.91154064
140Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90703844
141Abnormality of the vocal cords (HP:0008777)1.90067700
142Microvesicular hepatic steatosis (HP:0001414)1.90045856
143Type 2 muscle fiber atrophy (HP:0003554)1.89737908
144Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87328841
145Abnormality of renal resorption (HP:0011038)1.87145729
146Cerebral hypomyelination (HP:0006808)1.86045662
147B lymphocytopenia (HP:0010976)1.85200693
148Metabolic acidosis (HP:0001942)1.84842630
149Focal seizures (HP:0007359)1.84703278
150Dialeptic seizures (HP:0011146)1.83722165
151Generalized tonic-clonic seizures (HP:0002069)1.82332008
152IgG deficiency (HP:0004315)1.81479626
153Cerebral palsy (HP:0100021)1.80996185
154Retinitis pigmentosa (HP:0000510)1.78169912
155Chronic hepatic failure (HP:0100626)1.77701199
156Abnormal protein glycosylation (HP:0012346)1.77557318
157Abnormal glycosylation (HP:0012345)1.77557318
158Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77557318
159Abnormal protein N-linked glycosylation (HP:0012347)1.77557318
160Attenuation of retinal blood vessels (HP:0007843)1.75727627
161Polydipsia (HP:0001959)1.74582820
162Abnormal drinking behavior (HP:0030082)1.74582820
163Abnormality of B cell number (HP:0010975)1.74176642
164Stomatitis (HP:0010280)1.73632842
165Leukodystrophy (HP:0002415)1.73047645
166Abnormal respiratory motile cilium morphology (HP:0005938)1.72660545
167Abnormal respiratory epithelium morphology (HP:0012253)1.72660545
168Cystic liver disease (HP:0006706)1.72258133
169Agammaglobulinemia (HP:0004432)1.71953552
170Type I transferrin isoform profile (HP:0003642)1.70749600
171Opisthotonus (HP:0002179)1.69530012
172Neutropenia (HP:0001875)1.67444729
173Sclerocornea (HP:0000647)1.63418159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.02823424
2MAP4K23.30547403
3MAP2K73.11597530
4VRK23.02474591
5PDK42.84609056
6PDK32.84609056
7NME12.56427329
8MYLK2.48790606
9BCKDK2.47513311
10PHKG22.33726520
11PHKG12.33726520
12MAP3K42.32013752
13PINK12.26312988
14NEK12.12543071
15BMPR1B2.11641776
16CASK2.05446084
17DYRK22.05191958
18CCNB11.98434394
19SIK31.84034708
20MAP2K41.79232031
21MAPK151.77230144
22KIT1.74290387
23OBSCN1.73705951
24NUAK11.69669221
25SIK21.66233012
26SGK21.62527186
27GRK11.58565125
28NTRK31.58111492
29DAPK11.55586885
30TESK21.54756145
31PDK21.49392543
32LMTK21.48087369
33CAMKK21.47541399
34MAP4K11.43714841
35DAPK21.40071788
36MUSK1.37985154
37MINK11.36195104
38ADRBK21.32083892
39TTN1.31578540
40INSRR1.29149143
41MARK11.26912544
42PIM21.25210094
43VRK11.23590530
44MAP2K61.21769335
45WNK41.20817849
46CDK191.20728014
47TIE11.20252921
48CSNK1G31.18472834
49SGK31.13698628
50NTRK21.13281783
51SGK2231.11950437
52SGK4941.11950437
53FES1.08726348
54TSSK61.08047090
55GRK51.02465879
56TAOK31.02443221
57SYK1.01856149
58EPHA31.01538162
59TRIM281.01218714
60ZAP701.00986632
61WNK31.00793899
62TNK21.00256564
63FLT31.00124787
64ZAK0.99577632
65CSNK1G20.99463735
66LIMK10.98154181
67AKT30.95053273
68TEC0.87612995
69CSNK1G10.84969142
70DYRK1B0.84685057
71STK240.82186368
72STK160.81955153
73UHMK10.81449510
74CAMK10.80509924
75TXK0.80176015
76IKBKB0.79396453
77CSNK1A1L0.78879415
78IKBKE0.78413719
79MAP3K10.76634498
80PRKG20.76501368
81PRPF4B0.76389943
82MAPKAPK50.75957470
83PRKCQ0.75113259
84LRRK20.73900044
85FRK0.72205812
86GRK70.70274668
87LYN0.69448836
88PRKCH0.68847034
89PASK0.68185251
90STK380.67755723
91PKN20.66747526
92PKN10.65068736
93ADRBK10.64677197
94TBK10.64251193
95LCK0.64158128
96PRKD30.62901852
97PRKCI0.61115011
98MAP3K70.61101512
99MOS0.60365813
100RPS6KA50.60121865
101HIPK20.59113716
102CAMKK10.58951510
103PRKCG0.58026883
104CDK80.57898999
105RET0.57693417
106ARAF0.55883035
107PAK60.55532825
108TESK10.54781962
109BTK0.54075758
110MAP3K110.53794837
111RIPK40.53650446
112FGFR40.51895827
113GRK60.51808807
114CDK50.50395620
115PRKAA10.50307071
116MAPK130.49721714
117EPHA40.48854845
118MAPK120.48319257
119MAPKAPK30.47837009
120ERBB30.47306989
121RPS6KA20.47294073
122ITK0.46501638
123JAK10.46235935
124CAMK2D0.46014182
125PDK10.45653215
126IRAK10.45186094
127DYRK1A0.44580199
128PIK3CG0.44156114
129TLK10.43228184
130KDR0.43019942
131CAMK2A0.42983362
132PRKCD0.42916423
133SCYL20.42902833
134TAOK20.42876602
135NEK90.42148494
136PRKCE0.42022843
137CDC42BPA0.41384790
138EIF2AK20.41283259
139MAP3K20.40710039
140PRKACA0.40111942
141RPS6KL10.39718715
142RPS6KC10.39718715
143MAP3K90.39648204
144MAP3K50.39475644
145SGK10.39381310
146PAK30.39081310
147PRKCA0.38499787
148MARK30.38368535
149CSNK1A10.36775211
150DAPK30.35925355
151AURKA0.35891421

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.68665991
2Ribosome_Homo sapiens_hsa030103.28640346
3Oxidative phosphorylation_Homo sapiens_hsa001903.20969600
4Parkinsons disease_Homo sapiens_hsa050123.09353363
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.04604459
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.99560018
7Synaptic vesicle cycle_Homo sapiens_hsa047212.80667626
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.80177324
9Collecting duct acid secretion_Homo sapiens_hsa049662.48731905
10Pyruvate metabolism_Homo sapiens_hsa006202.23875509
11Alzheimers disease_Homo sapiens_hsa050102.22579451
12Propanoate metabolism_Homo sapiens_hsa006402.21672215
13Cardiac muscle contraction_Homo sapiens_hsa042602.18167672
14RNA polymerase_Homo sapiens_hsa030202.00246513
15Insulin secretion_Homo sapiens_hsa049111.86964621
16Olfactory transduction_Homo sapiens_hsa047401.84471170
17Huntingtons disease_Homo sapiens_hsa050161.80539073
18Carbon metabolism_Homo sapiens_hsa012001.75376906
19Vibrio cholerae infection_Homo sapiens_hsa051101.72630471
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.70586427
21Nicotine addiction_Homo sapiens_hsa050331.66678430
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63025043
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57971035
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57925386
25Phototransduction_Homo sapiens_hsa047441.57679273
26Sulfur relay system_Homo sapiens_hsa041221.52083212
27Base excision repair_Homo sapiens_hsa034101.48528399
28Circadian entrainment_Homo sapiens_hsa047131.48322907
29GABAergic synapse_Homo sapiens_hsa047271.48288893
30Asthma_Homo sapiens_hsa053101.42164718
31Fructose and mannose metabolism_Homo sapiens_hsa000511.42048490
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40969894
33Taste transduction_Homo sapiens_hsa047421.40730303
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40614220
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40491700
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40134136
37Amphetamine addiction_Homo sapiens_hsa050311.39250371
38Morphine addiction_Homo sapiens_hsa050321.38088051
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37537202
40Fatty acid degradation_Homo sapiens_hsa000711.29897395
41Fatty acid elongation_Homo sapiens_hsa000621.29110966
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27929243
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.23005331
44Linoleic acid metabolism_Homo sapiens_hsa005911.22847379
45Gastric acid secretion_Homo sapiens_hsa049711.21644078
46Fanconi anemia pathway_Homo sapiens_hsa034601.21505748
47Galactose metabolism_Homo sapiens_hsa000521.20784955
48Butanoate metabolism_Homo sapiens_hsa006501.19768304
49Allograft rejection_Homo sapiens_hsa053301.17648132
50Long-term potentiation_Homo sapiens_hsa047201.15819208
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15184015
52Dopaminergic synapse_Homo sapiens_hsa047281.10551532
53Graft-versus-host disease_Homo sapiens_hsa053321.09354582
54Glucagon signaling pathway_Homo sapiens_hsa049221.08794347
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08768630
56Dilated cardiomyopathy_Homo sapiens_hsa054141.06686948
57Protein export_Homo sapiens_hsa030601.06220945
58Calcium signaling pathway_Homo sapiens_hsa040201.05230805
59Autoimmune thyroid disease_Homo sapiens_hsa053201.04828503
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04040718
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00322786
62Sulfur metabolism_Homo sapiens_hsa009201.00105703
63Circadian rhythm_Homo sapiens_hsa047100.99968134
64Pyrimidine metabolism_Homo sapiens_hsa002400.99129550
65Salivary secretion_Homo sapiens_hsa049700.94637391
66Renin secretion_Homo sapiens_hsa049240.94424076
67Homologous recombination_Homo sapiens_hsa034400.94026749
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.91512252
69Cocaine addiction_Homo sapiens_hsa050300.88909907
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88130518
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88022836
72Proteasome_Homo sapiens_hsa030500.87788844
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86192880
74Arachidonic acid metabolism_Homo sapiens_hsa005900.80828945
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78626931
76Cholinergic synapse_Homo sapiens_hsa047250.78608501
77Antigen processing and presentation_Homo sapiens_hsa046120.77065102
78Oxytocin signaling pathway_Homo sapiens_hsa049210.75833838
79Fatty acid metabolism_Homo sapiens_hsa012120.75575892
80Biosynthesis of amino acids_Homo sapiens_hsa012300.74980551
81Glutamatergic synapse_Homo sapiens_hsa047240.74949025
82RNA degradation_Homo sapiens_hsa030180.74453362
83Type II diabetes mellitus_Homo sapiens_hsa049300.73675403
84Arginine and proline metabolism_Homo sapiens_hsa003300.72195349
85Starch and sucrose metabolism_Homo sapiens_hsa005000.70939421
86Insulin signaling pathway_Homo sapiens_hsa049100.70358025
87Chemical carcinogenesis_Homo sapiens_hsa052040.70270955
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70187722
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68713620
90Folate biosynthesis_Homo sapiens_hsa007900.68664396
91Ether lipid metabolism_Homo sapiens_hsa005650.67673820
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66293957
93Spliceosome_Homo sapiens_hsa030400.65964544
94Tyrosine metabolism_Homo sapiens_hsa003500.64139939
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62773600
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62631097
97Regulation of autophagy_Homo sapiens_hsa041400.60995544
98Fat digestion and absorption_Homo sapiens_hsa049750.60125190
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60097692
100Basal transcription factors_Homo sapiens_hsa030220.59726178
101Glutathione metabolism_Homo sapiens_hsa004800.58753697
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.57297111
103Nitrogen metabolism_Homo sapiens_hsa009100.57008938
104Type I diabetes mellitus_Homo sapiens_hsa049400.56198127
105ABC transporters_Homo sapiens_hsa020100.56156887
106Phenylalanine metabolism_Homo sapiens_hsa003600.55658385
107Serotonergic synapse_Homo sapiens_hsa047260.52584030
108Insulin resistance_Homo sapiens_hsa049310.52122352
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51979043
110Peroxisome_Homo sapiens_hsa041460.50810797
111Pancreatic secretion_Homo sapiens_hsa049720.49973266
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48637153
113cAMP signaling pathway_Homo sapiens_hsa040240.48039370
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47707610
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47599136
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46389462
117Primary immunodeficiency_Homo sapiens_hsa053400.45949684
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45450494
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.44893819
120Mismatch repair_Homo sapiens_hsa034300.44696023
121Glycerolipid metabolism_Homo sapiens_hsa005610.44688526
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44167809
123N-Glycan biosynthesis_Homo sapiens_hsa005100.44096295
124Thyroid hormone synthesis_Homo sapiens_hsa049180.43912889
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.43342187
126Other glycan degradation_Homo sapiens_hsa005110.42490539
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40510438
128Retinol metabolism_Homo sapiens_hsa008300.39358903
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38509052
130GnRH signaling pathway_Homo sapiens_hsa049120.37884029
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37738349
132beta-Alanine metabolism_Homo sapiens_hsa004100.37528302
133DNA replication_Homo sapiens_hsa030300.37069683
134Metabolic pathways_Homo sapiens_hsa011000.36585039
135Pentose phosphate pathway_Homo sapiens_hsa000300.36556723
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36230038
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35790649
138Steroid biosynthesis_Homo sapiens_hsa001000.35782336
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35715756
140Tryptophan metabolism_Homo sapiens_hsa003800.35655294
141Caffeine metabolism_Homo sapiens_hsa002320.33771250
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33443775
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.32179671
144Inositol phosphate metabolism_Homo sapiens_hsa005620.31874693
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.30467288
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29738460
147Purine metabolism_Homo sapiens_hsa002300.26476283
148Rheumatoid arthritis_Homo sapiens_hsa053230.22448548
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22173359
150Gap junction_Homo sapiens_hsa045400.18382047

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