SDR42E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.50997913
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.50997913
3L-phenylalanine metabolic process (GO:0006558)7.16717945
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.16717945
5aromatic amino acid family catabolic process (GO:0009074)6.72612642
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.25746366
7tryptophan catabolic process (GO:0006569)6.07344175
8indole-containing compound catabolic process (GO:0042436)6.07344175
9indolalkylamine catabolic process (GO:0046218)6.07344175
10kynurenine metabolic process (GO:0070189)5.98024911
11bile acid biosynthetic process (GO:0006699)5.91647230
12tryptophan metabolic process (GO:0006568)5.71978771
13glyoxylate metabolic process (GO:0046487)5.63211002
14alpha-linolenic acid metabolic process (GO:0036109)5.58094503
15high-density lipoprotein particle remodeling (GO:0034375)5.54862995
16urea metabolic process (GO:0019627)5.50370638
17urea cycle (GO:0000050)5.50370638
18negative regulation of fibrinolysis (GO:0051918)5.47430165
19sulfur amino acid catabolic process (GO:0000098)5.37781777
20regulation of fibrinolysis (GO:0051917)5.30806975
21cysteine metabolic process (GO:0006534)5.30704075
22peptidyl-glutamic acid carboxylation (GO:0017187)5.29031366
23protein carboxylation (GO:0018214)5.29031366
24complement activation, alternative pathway (GO:0006957)5.24867379
25regulation of protein activation cascade (GO:2000257)5.20786879
26bile acid metabolic process (GO:0008206)5.07131583
27nitrogen cycle metabolic process (GO:0071941)5.06943425
28serine family amino acid catabolic process (GO:0009071)5.00247632
29aromatic amino acid family metabolic process (GO:0009072)4.89036360
30regulation of cholesterol esterification (GO:0010872)4.86881499
31regulation of complement activation (GO:0030449)4.85820080
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85012989
33regulation of triglyceride catabolic process (GO:0010896)4.84287163
34reverse cholesterol transport (GO:0043691)4.79169883
35L-fucose catabolic process (GO:0042355)4.76176603
36fucose catabolic process (GO:0019317)4.76176603
37L-fucose metabolic process (GO:0042354)4.76176603
38tyrosine metabolic process (GO:0006570)4.74516525
39protein-lipid complex remodeling (GO:0034368)4.70867259
40macromolecular complex remodeling (GO:0034367)4.70867259
41plasma lipoprotein particle remodeling (GO:0034369)4.70867259
42phospholipid efflux (GO:0033700)4.65742769
43homocysteine metabolic process (GO:0050667)4.63129795
44acylglycerol homeostasis (GO:0055090)4.58640871
45triglyceride homeostasis (GO:0070328)4.58640871
46alpha-amino acid catabolic process (GO:1901606)4.56072331
47negative regulation of cholesterol transport (GO:0032375)4.56020355
48negative regulation of sterol transport (GO:0032372)4.56020355
49amino-acid betaine metabolic process (GO:0006577)4.55356536
50DNA deamination (GO:0045006)4.53601141
51lysine metabolic process (GO:0006553)4.46391295
52lysine catabolic process (GO:0006554)4.46391295
53cellular ketone body metabolic process (GO:0046950)4.45002427
54bile acid and bile salt transport (GO:0015721)4.41480731
55coenzyme catabolic process (GO:0009109)4.41190858
56plasma lipoprotein particle clearance (GO:0034381)4.33715316
57indolalkylamine metabolic process (GO:0006586)4.33362979
58imidazole-containing compound metabolic process (GO:0052803)4.30212231
59ethanol oxidation (GO:0006069)4.27122988
60glycine metabolic process (GO:0006544)4.26750881
61cellular amino acid catabolic process (GO:0009063)4.21185424
62cellular glucuronidation (GO:0052695)4.21144672
63amine catabolic process (GO:0009310)4.21018654
64cellular biogenic amine catabolic process (GO:0042402)4.21018654
65glutamate metabolic process (GO:0006536)4.20149141
66cholesterol efflux (GO:0033344)4.20099322
67establishment of skin barrier (GO:0061436)4.16503300
68benzene-containing compound metabolic process (GO:0042537)4.14470723
69serine family amino acid metabolic process (GO:0009069)4.08156062
70cellular modified amino acid catabolic process (GO:0042219)4.04894598
71fibrinolysis (GO:0042730)4.00259726
72low-density lipoprotein particle remodeling (GO:0034374)3.97736726
73plasma lipoprotein particle assembly (GO:0034377)3.94812921
74serine family amino acid biosynthetic process (GO:0009070)3.94504543
75aldehyde catabolic process (GO:0046185)3.94083978
76dicarboxylic acid biosynthetic process (GO:0043650)3.91978063
77arginine metabolic process (GO:0006525)3.90197179
78ketone body metabolic process (GO:1902224)3.85587778
79drug catabolic process (GO:0042737)3.84045557
80negative regulation of lipase activity (GO:0060192)3.84041192
81signal peptide processing (GO:0006465)3.83765586
82keratinization (GO:0031424)3.83144360
83keratinocyte development (GO:0003334)3.78868615
84very-low-density lipoprotein particle assembly (GO:0034379)3.76780510
85cofactor catabolic process (GO:0051187)3.76568156
86blood coagulation, intrinsic pathway (GO:0007597)3.76402892
87glucuronate metabolic process (GO:0019585)3.73988336
88uronic acid metabolic process (GO:0006063)3.73988336
89positive regulation of lipoprotein lipase activity (GO:0051006)3.73754591
90positive regulation of triglyceride lipase activity (GO:0061365)3.73754591
91complement activation, classical pathway (GO:0006958)3.72762584
92desmosome organization (GO:0002934)3.72590057
93short-chain fatty acid metabolic process (GO:0046459)3.71735138
94positive regulation of lipid catabolic process (GO:0050996)3.71487971
95carboxylic acid catabolic process (GO:0046395)3.70181855
96organic acid catabolic process (GO:0016054)3.70181855
97complement activation (GO:0006956)3.69635724
98cholesterol homeostasis (GO:0042632)3.69469960
99regulation of bile acid biosynthetic process (GO:0070857)3.68985832
100protein activation cascade (GO:0072376)3.67360585
101regulation of cholesterol homeostasis (GO:2000188)3.67249912
102acetyl-CoA metabolic process (GO:0006084)3.66682661
103phospholipid homeostasis (GO:0055091)3.66661799
104sterol homeostasis (GO:0055092)3.63218436
105cytolysis (GO:0019835)3.59848734
106plasma lipoprotein particle organization (GO:0071827)3.56888416
107protein-lipid complex assembly (GO:0065005)3.54222943
108phosphatidylinositol acyl-chain remodeling (GO:0036149)3.52772717
109intestinal epithelial cell development (GO:0060576)3.51095672
110opsonization (GO:0008228)3.50714754
111regulation of water loss via skin (GO:0033561)3.50594245
112response to nitrosative stress (GO:0051409)3.49471725
113behavioral response to nicotine (GO:0035095)3.48315855
114keratinocyte proliferation (GO:0043616)3.46455033
115piRNA metabolic process (GO:0034587)3.42431483
116response to pheromone (GO:0019236)3.42372548
117phosphatidylserine acyl-chain remodeling (GO:0036150)3.34393112
118epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27333276
119respiratory chain complex IV assembly (GO:0008535)3.21935578
120terpenoid biosynthetic process (GO:0016114)3.20447387
121regulation of hexokinase activity (GO:1903299)3.17574892
122regulation of glucokinase activity (GO:0033131)3.17574892
123bundle of His cell to Purkinje myocyte communication (GO:0086069)3.17156873
124axoneme assembly (GO:0035082)3.17082959
125phenylpropanoid metabolic process (GO:0009698)3.09357374
126diterpenoid biosynthetic process (GO:0016102)3.07304555
127nucleotide transmembrane transport (GO:1901679)3.03460282
128reflex (GO:0060004)3.01504309
129phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.99972769
130platelet dense granule organization (GO:0060155)2.92306092
131exogenous drug catabolic process (GO:0042738)2.90728597
132epithelial cilium movement (GO:0003351)2.90295275
133multicellular organism reproduction (GO:0032504)2.90223750
134detection of light stimulus involved in sensory perception (GO:0050962)2.89751103
135detection of light stimulus involved in visual perception (GO:0050908)2.89751103
136polyol catabolic process (GO:0046174)2.89126034
137establishment of protein localization to Golgi (GO:0072600)2.87915759
138magnesium ion transport (GO:0015693)2.80421854
139oxidative demethylation (GO:0070989)2.76692474
140cilium movement (GO:0003341)2.76080900
141dopamine transport (GO:0015872)2.75535558
142thyroid hormone metabolic process (GO:0042403)2.75355286
143regulation of cilium movement (GO:0003352)2.74610987
144kidney morphogenesis (GO:0060993)2.72170883
145inositol phosphate catabolic process (GO:0071545)2.69946315
146DNA methylation involved in gamete generation (GO:0043046)2.69442027
147flavonoid metabolic process (GO:0009812)2.68127712
148hair cycle (GO:0042633)2.67463787
149molting cycle (GO:0042303)2.67463787
150rRNA catabolic process (GO:0016075)2.67288835
151multicellular organismal water homeostasis (GO:0050891)2.66801487
152cornea development in camera-type eye (GO:0061303)2.66651478
153mannosylation (GO:0097502)2.66060718
154S-adenosylmethionine metabolic process (GO:0046500)2.65492596
155water-soluble vitamin biosynthetic process (GO:0042364)2.65200507
156cilium or flagellum-dependent cell motility (GO:0001539)2.64595220
157detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64487289
158branched-chain amino acid catabolic process (GO:0009083)2.63703524
159preassembly of GPI anchor in ER membrane (GO:0016254)2.63537377
160protein targeting to Golgi (GO:0000042)2.63414144
161cytochrome complex assembly (GO:0017004)2.63094325
162synapsis (GO:0007129)2.61877899
163axonemal dynein complex assembly (GO:0070286)2.60683647
164protein K11-linked deubiquitination (GO:0035871)2.59475596
165positive regulation of prostaglandin secretion (GO:0032308)2.57951276
166water homeostasis (GO:0030104)2.57867317
167oocyte development (GO:0048599)2.56896983
168phosphorylated carbohydrate dephosphorylation (GO:0046838)2.56229599
169inositol phosphate dephosphorylation (GO:0046855)2.56229599
170fucosylation (GO:0036065)2.55799822
171negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.54681199
172positive regulation of fatty acid transport (GO:2000193)2.53889535
173auditory receptor cell differentiation (GO:0042491)2.51822035
174phosphatidylcholine acyl-chain remodeling (GO:0036151)2.50723303
175righting reflex (GO:0060013)2.49708626
176regulation of male gonad development (GO:2000018)2.47813094
177positive regulation of defense response to virus by host (GO:0002230)2.41453980
178photoreceptor cell maintenance (GO:0045494)2.41319054
179positive regulation of icosanoid secretion (GO:0032305)2.40140648
180drug metabolic process (GO:0017144)2.38424384
181indole-containing compound metabolic process (GO:0042430)2.37612598
182retrograde transport, vesicle recycling within Golgi (GO:0000301)2.36894772
183phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.35998931
184neural tube formation (GO:0001841)2.35917758
185regulation of meiosis I (GO:0060631)2.35862426
186purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.35812208
1873-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.35812208
188negative regulation of execution phase of apoptosis (GO:1900118)2.35496637
189L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.35384807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.14050556
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.00483309
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.80240655
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.32675272
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.20242337
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.88798465
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83008013
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.94322700
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.80939226
10ZNF274_21170338_ChIP-Seq_K562_Hela3.38925555
11VDR_22108803_ChIP-Seq_LS180_Human2.88734370
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52350193
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.39192181
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32856692
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28065836
16ER_23166858_ChIP-Seq_MCF-7_Human2.17668895
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06642508
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5960727
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99813546
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.96297825
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91042639
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90178587
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87454647
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86517361
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85943014
26IGF1R_20145208_ChIP-Seq_DFB_Human1.85418448
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81934315
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80610468
29FUS_26573619_Chip-Seq_HEK293_Human1.78776475
30* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78024768
31FOXA1_25329375_ChIP-Seq_VCAP_Human1.68431867
32FOXA1_27270436_Chip-Seq_PROSTATE_Human1.68431867
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65258272
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60102626
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.59859099
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.59842230
37GBX2_23144817_ChIP-Seq_PC3_Human1.59565547
38HTT_18923047_ChIP-ChIP_STHdh_Human1.59369511
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59210554
40TCF4_22108803_ChIP-Seq_LS180_Human1.57663967
41FOXA1_21572438_ChIP-Seq_LNCaP_Human1.55189410
42EWS_26573619_Chip-Seq_HEK293_Human1.54562497
43CLOCK_20551151_ChIP-Seq_293T_Human1.52560830
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52237943
45CBP_20019798_ChIP-Seq_JUKART_Human1.49917723
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49917723
47STAT3_23295773_ChIP-Seq_U87_Human1.49455986
48P300_19829295_ChIP-Seq_ESCs_Human1.49413770
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.49111895
50TP53_22573176_ChIP-Seq_HFKS_Human1.45329006
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.42104933
52HOXB7_26014856_ChIP-Seq_BT474_Human1.41177815
53TCF4_23295773_ChIP-Seq_U87_Human1.41161381
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.40190943
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39915099
56AR_25329375_ChIP-Seq_VCAP_Human1.38088124
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37869812
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37647423
59SMAD4_21799915_ChIP-Seq_A2780_Human1.36578142
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35464443
61HNF4A_19822575_ChIP-Seq_HepG2_Human1.34570736
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.34099623
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34021194
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33182726
65AHR_22903824_ChIP-Seq_MCF-7_Human1.32950527
66NCOR_22424771_ChIP-Seq_293T_Human1.31935324
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31795139
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30635883
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30044652
70GATA1_22025678_ChIP-Seq_K562_Human1.29913933
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.29378357
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28621817
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28486628
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27464548
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.27407102
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26657568
77* SOX2_19829295_ChIP-Seq_ESCs_Human1.24274669
78* NANOG_19829295_ChIP-Seq_ESCs_Human1.24274669
79IRF1_19129219_ChIP-ChIP_H3396_Human1.24254953
80* TP63_23658742_ChIP-Seq_EP156T_Human1.22097825
81VDR_23849224_ChIP-Seq_CD4+_Human1.21378148
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20653255
83GATA3_26560356_Chip-Seq_TH2_Human1.20388895
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17440672
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15316124
86RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15210250
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14764634
88ELK1_19687146_ChIP-ChIP_HELA_Human1.14395838
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.09395485
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.08932445
91RBPJ_21746931_ChIP-Seq_IB4_Human1.08757046
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08269043
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06978864
94* FOXH1_21741376_ChIP-Seq_EPCs_Human1.06948052
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06710303
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.06596691
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.06081110
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05661558
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04837111
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.04239865
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04204252
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03862363
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03862363
104P53_22387025_ChIP-Seq_ESCs_Mouse1.03769413
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03605037
106* SMAD4_21741376_ChIP-Seq_EPCs_Human1.02914861
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02782015
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02526607
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02328800
110TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02221423
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01991870
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00505072
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99732311
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96369944
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92549277
116GATA4_25053715_ChIP-Seq_YYC3_Human0.91312791
117ESR2_21235772_ChIP-Seq_MCF-7_Human0.89222581
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87896108
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85128612
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80737540
121IRF8_22096565_ChIP-ChIP_GC-B_Human0.80088663
122ZNF263_19887448_ChIP-Seq_K562_Human0.79687645
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76496207
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75442115
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74978093
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73323334
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73059093
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73059093
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72398819
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71567528
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70507809
132RARA_24833708_ChIP-Seq_LIVER_Mouse0.68587587
133ESR1_21235772_ChIP-Seq_MCF-7_Human0.67376084
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66927281
135SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66319597
136CEBPB_22108803_ChIP-Seq_LS180_Human0.65905281
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65298409
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61997471
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60894393
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.60630308
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60261754
142TAF15_26573619_Chip-Seq_HEK293_Human0.60183681
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.58987976
144EGR1_19032775_ChIP-ChIP_M12_Human0.58589003
145* RARB_24833708_ChIP-Seq_LIVER_Mouse0.58214805
146LXR_22292898_ChIP-Seq_THP-1_Human0.56944709
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56802928
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.54757609
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.54725226
150CDX2_20551321_ChIP-Seq_CACO-2_Human0.54694032
151MYC_19915707_ChIP-ChIP_AK7_Human0.54352956
152AR_20517297_ChIP-Seq_VCAP_Human0.54257340
153P53_21459846_ChIP-Seq_SAOS-2_Human0.52323887
154CBP_21632823_ChIP-Seq_H3396_Human0.51166206
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.50622615
156FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50489858
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.49854525
158NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.49503827
159BCAT_22108803_ChIP-Seq_LS180_Human0.49037671
160STAT1_17558387_ChIP-Seq_HELA_Human0.48909456
161PPAR_26484153_Chip-Seq_NCI-H1993_Human0.47546736
162TP63_17297297_ChIP-ChIP_HaCaT_Human0.47132544
163SOX2_20726797_ChIP-Seq_SW620_Human0.46769565
164SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46502862
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45552419
166GATA1_19941826_ChIP-Seq_K562_Human0.45234539
167FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44703462
168GATA6_25053715_ChIP-Seq_YYC3_Human0.44577463
169PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44135535
170PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43984789
171TAF2_19829295_ChIP-Seq_ESCs_Human0.43866060
172GATA2_19941826_ChIP-Seq_K562_Human0.42847924
173CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41016475
174CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.40848562
175* GATA3_24758297_ChIP-Seq_MCF-7_Human0.39833933
176P63_26484246_Chip-Seq_KERATINOCYTES_Human0.39163919
177E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.38426990
178P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.38329112
179STAT3_1855785_ChIP-Seq_MESCs_Mouse0.38051609
180MYC_27129775_Chip-Seq_CORNEA_Mouse0.38020393
181GATA1_19941827_ChIP-Seq_MEL_Mouse0.38015070
182SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37228733
183SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.36692787
184CDX2_22108803_ChIP-Seq_LS180_Human0.36675739
185ERG_20517297_ChIP-Seq_VCAP_Human0.36207144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.25796947
2MP0005360_urolithiasis7.35220148
3MP0005085_abnormal_gallbladder_physiolo6.33152875
4MP0005365_abnormal_bile_salt6.12195392
5MP0008875_abnormal_xenobiotic_pharmacok5.09716529
6MP0003806_abnormal_nucleotide_metabolis4.22272881
7MP0003252_abnormal_bile_duct3.80566456
8MP0010329_abnormal_lipoprotein_level3.55604806
9MP0009840_abnormal_foam_cell3.31812702
10MP0005083_abnormal_biliary_tract3.06127327
11MP0003195_calcinosis2.94797831
12MP0000383_abnormal_hair_follicle2.68617526
13MP0005332_abnormal_amino_acid2.68230587
14MP0010678_abnormal_skin_adnexa2.67949955
15MP0001666_abnormal_nutrient_absorption2.64191075
16MP0003191_abnormal_cellular_cholesterol2.35548173
17MP0008877_abnormal_DNA_methylation2.32927407
18MP0005645_abnormal_hypothalamus_physiol2.30559600
19MP0005075_abnormal_melanosome_morpholog2.22143070
20MP0004019_abnormal_vitamin_homeostasis2.12386506
21MP0004043_abnormal_pH_regulation2.12148856
22MP0000609_abnormal_liver_physiology2.11562037
23MP0002118_abnormal_lipid_homeostasis2.10143276
24MP0000569_abnormal_digit_pigmentation2.05467833
25MP0004885_abnormal_endolymph2.01626528
26MP0009780_abnormal_chondrocyte_physiolo1.94184376
27MP0003868_abnormal_feces_composition1.85221308
28MP0002909_abnormal_adrenal_gland1.82055791
29MP0002138_abnormal_hepatobiliary_system1.80178568
30MP0005319_abnormal_enzyme/_coenzyme1.76599786
31MP0005451_abnormal_body_composition1.74525722
32MP0005551_abnormal_eye_electrophysiolog1.69190368
33MP0002163_abnormal_gland_morphology1.68362291
34MP0003011_delayed_dark_adaptation1.60077307
35MP0001764_abnormal_homeostasis1.57455937
36MP0005584_abnormal_enzyme/coenzyme_acti1.55677789
37MP0002098_abnormal_vibrissa_morphology1.52801297
38MP0005646_abnormal_pituitary_gland1.52481634
39MP0009697_abnormal_copulation1.49993268
40MP0003878_abnormal_ear_physiology1.49907040
41MP0005377_hearing/vestibular/ear_phenot1.49907040
42MP0001501_abnormal_sleep_pattern1.49181004
43MP0002693_abnormal_pancreas_physiology1.46153974
44MP0005174_abnormal_tail_pigmentation1.46054179
45MP0003787_abnormal_imprinting1.45171517
46MP0006072_abnormal_retinal_apoptosis1.39862377
47MP0001216_abnormal_epidermal_layer1.35037091
48MP0002160_abnormal_reproductive_system1.33674667
49MP0002095_abnormal_skin_pigmentation1.33097192
50MP0001485_abnormal_pinna_reflex1.30156280
51MP0002102_abnormal_ear_morphology1.29476969
52MP0010386_abnormal_urinary_bladder1.28354556
53MP0005389_reproductive_system_phenotype1.24824084
54MP0003705_abnormal_hypodermis_morpholog1.23658597
55MP0002254_reproductive_system_inflammat1.22776008
56MP0001765_abnormal_ion_homeostasis1.22091140
57MP0005379_endocrine/exocrine_gland_phen1.21007647
58MP0009643_abnormal_urine_homeostasis1.20972370
59MP0003186_abnormal_redox_activity1.19957893
60MP0000372_irregular_coat_pigmentation1.19583409
61MP0003656_abnormal_erythrocyte_physiolo1.18932193
62MP0000538_abnormal_urinary_bladder1.18076888
63MP0001873_stomach_inflammation1.18041094
64MP0002638_abnormal_pupillary_reflex1.15594389
65MP0002234_abnormal_pharynx_morphology1.14936388
66MP0005647_abnormal_sex_gland1.14638377
67MP0000604_amyloidosis1.10719906
68MP0003866_abnormal_defecation1.10698950
69MP0001944_abnormal_pancreas_morphology1.10188070
70MP0000631_abnormal_neuroendocrine_gland1.09670993
71MP0000015_abnormal_ear_pigmentation1.08363906
72MP0000598_abnormal_liver_morphology1.08260773
73MP0004264_abnormal_extraembryonic_tissu1.07194092
74MP0010771_integument_phenotype1.07011482
75MP0005310_abnormal_salivary_gland1.05809132
76MP0003943_abnormal_hepatobiliary_system1.03724607
77MP0000377_abnormal_hair_follicle1.03317362
78MP0009764_decreased_sensitivity_to1.02500020
79MP0001919_abnormal_reproductive_system1.01030860
80MP0002166_altered_tumor_susceptibility1.00759013
81MP0009046_muscle_twitch1.00753991
82MP0001905_abnormal_dopamine_level1.00136339
83MP0002006_tumorigenesis0.99580751
84MP0003763_abnormal_thymus_physiology0.99270699
85MP0009763_increased_sensitivity_to0.97850261
86MP0004147_increased_porphyrin_level0.93547210
87MP0005253_abnormal_eye_physiology0.93173783
88MP0004142_abnormal_muscle_tone0.93104046
89MP0003045_fibrosis0.92973396
90MP0005671_abnormal_response_to0.91896348
91MP0005636_abnormal_mineral_homeostasis0.91095038
92MP0002796_impaired_skin_barrier0.90904878
93MP0000566_synostosis0.89712442
94MP0001664_abnormal_digestion0.89309253
95MP0010368_abnormal_lymphatic_system0.87770954
96MP0003786_premature_aging0.87410169
97MP0002938_white_spotting0.86325536
98MP0005410_abnormal_fertilization0.85707997
99MP0000613_abnormal_salivary_gland0.85315600
100MP0008469_abnormal_protein_level0.85047401
101MP0005408_hypopigmentation0.84896718
102MP0009642_abnormal_blood_homeostasis0.83678690
103MP0001984_abnormal_olfaction0.83483010
104MP0000367_abnormal_coat/_hair0.83434206
105MP0000470_abnormal_stomach_morphology0.82262518
106MP0004924_abnormal_behavior0.81876923
107MP0005386_behavior/neurological_phenoty0.81876923
108MP0004381_abnormal_hair_follicle0.79664757
109MP0002653_abnormal_ependyma_morphology0.79581994
110MP0009765_abnormal_xenobiotic_induced0.77032205
111MP0006036_abnormal_mitochondrial_physio0.75725913
112MP0005376_homeostasis/metabolism_phenot0.74861950
113MP0002876_abnormal_thyroid_physiology0.74309874
114MP0005670_abnormal_white_adipose0.73850107
115MP0002078_abnormal_glucose_homeostasis0.73188503
116MP0002971_abnormal_brown_adipose0.72436585
117MP0003329_amyloid_beta_deposits0.72408431
118MP0003690_abnormal_glial_cell0.71187812
119MP0005220_abnormal_exocrine_pancreas0.68642282
120MP0005334_abnormal_fat_pad0.67858313
121MP0004130_abnormal_muscle_cell0.67683335
122MP0005084_abnormal_gallbladder_morpholo0.66987468
123MP0005535_abnormal_body_temperature0.66453841
124MP0001661_extended_life_span0.65564430
125MP0000579_abnormal_nail_morphology0.62923408
126MP0010234_abnormal_vibrissa_follicle0.62778653
127MP0009053_abnormal_anal_canal0.61976381
128MP0002822_catalepsy0.60016453
129MP0005266_abnormal_metabolism0.59334197
130MP0000639_abnormal_adrenal_gland0.58968799
131MP0001756_abnormal_urination0.58235462
132MP0005448_abnormal_energy_balance0.54175277
133MP0006035_abnormal_mitochondrial_morpho0.53148703
134MP0005464_abnormal_platelet_physiology0.53010274
135MP0004782_abnormal_surfactant_physiolog0.51817038
136MP0003638_abnormal_response/metabolism_0.50101917
137MP0008874_decreased_physiological_sensi0.47165758
138MP0002060_abnormal_skin_morphology0.46945628
139MP0002136_abnormal_kidney_physiology0.44527263
140MP0003075_altered_response_to0.43635429
141MP0005395_other_phenotype0.43089571
142MP0008873_increased_physiological_sensi0.43029831
143MP0003724_increased_susceptibility_to0.41392068
144MP0000427_abnormal_hair_cycle0.40431123
145MP0005666_abnormal_adipose_tissue0.39867361
146MP0002837_dystrophic_cardiac_calcinosis0.39375253
147MP0003718_maternal_effect0.38984351
148MP0003953_abnormal_hormone_level0.38854844
149MP0001243_abnormal_dermal_layer0.38385222
150MP0003436_decreased_susceptibility_to0.38236571
151MP0008872_abnormal_physiological_respon0.37986730
152MP0005166_decreased_susceptibility_to0.37797834
153MP0005248_abnormal_Harderian_gland0.37173713
154MP0009384_cardiac_valve_regurgitation0.36419489
155MP0002928_abnormal_bile_duct0.36319213
156MP0003453_abnormal_keratinocyte_physiol0.36066395
157MP0000647_abnormal_sebaceous_gland0.34371969
158MP0005501_abnormal_skin_physiology0.33010710
159MP0004947_skin_inflammation0.32760950
160MP0001881_abnormal_mammary_gland0.32759118
161MP0006082_CNS_inflammation0.32393241
162MP0000230_abnormal_systemic_arterial0.31834641
163MP0009115_abnormal_fat_cell0.31378105
164MP0009672_abnormal_birth_weight0.31185041
165MP0002090_abnormal_vision0.31180895
166MP0002970_abnormal_white_adipose0.30008819
167MP0000249_abnormal_blood_vessel0.29237410

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.36703639
2Intrahepatic cholestasis (HP:0001406)7.35815576
3Deep venous thrombosis (HP:0002625)7.33178830
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.58599526
5Prolonged partial thromboplastin time (HP:0003645)6.52512685
6Hypobetalipoproteinemia (HP:0003563)6.33002950
7Xanthomatosis (HP:0000991)6.31956954
8Hyperlipoproteinemia (HP:0010980)5.70081544
9Complement deficiency (HP:0004431)5.32510772
10Hypolipoproteinemia (HP:0010981)4.73152449
11Joint hemorrhage (HP:0005261)4.71666247
12Hyperammonemia (HP:0001987)4.58058758
13Epidermoid cyst (HP:0200040)4.49690026
14Hyperglycinemia (HP:0002154)4.44496944
15Abnormality of the common coagulation pathway (HP:0010990)4.38229325
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.36918132
17Ketosis (HP:0001946)4.21169054
18Fat malabsorption (HP:0002630)4.18417443
19Abnormality of methionine metabolism (HP:0010901)4.15769432
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.15412036
21Hypoalphalipoproteinemia (HP:0003233)4.13514469
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.00691989
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.00327440
24Abnormality of glycine metabolism (HP:0010895)3.95623143
25Abnormality of serine family amino acid metabolism (HP:0010894)3.95623143
26Hyperglycinuria (HP:0003108)3.92175840
27Abnormality of complement system (HP:0005339)3.88936382
28Hypoglycemic coma (HP:0001325)3.82714150
29Conjugated hyperbilirubinemia (HP:0002908)3.79011469
30Abnormality of the intrinsic pathway (HP:0010989)3.66630373
31Pancreatic cysts (HP:0001737)3.63331444
32Hypercholesterolemia (HP:0003124)3.62992420
33Abnormality of pyrimidine metabolism (HP:0004353)3.59159755
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32026460
35Abnormality of fatty-acid metabolism (HP:0004359)3.30947118
36True hermaphroditism (HP:0010459)3.29020300
37Abnormality of midbrain morphology (HP:0002418)3.28711667
38Molar tooth sign on MRI (HP:0002419)3.28711667
39Hyperbilirubinemia (HP:0002904)3.26486360
40Steatorrhea (HP:0002570)3.20086898
41Hypothermia (HP:0002045)3.10899989
42Delayed CNS myelination (HP:0002188)3.10264559
43Abnormality of the renal cortex (HP:0011035)3.06044416
44Ketoacidosis (HP:0001993)3.02311130
45Myocardial infarction (HP:0001658)3.00053117
46Spontaneous abortion (HP:0005268)2.98569193
47Plantar hyperkeratosis (HP:0007556)2.98382178
48Pancreatic fibrosis (HP:0100732)2.97806656
49Abnormality of serum amino acid levels (HP:0003112)2.97705406
50Palmoplantar hyperkeratosis (HP:0000972)2.95300229
51Abnormality of nucleobase metabolism (HP:0010932)2.95148743
52Decreased circulating renin level (HP:0003351)2.86661653
53Hepatocellular carcinoma (HP:0001402)2.85332053
54Hypochromic microcytic anemia (HP:0004840)2.80272586
55Nephronophthisis (HP:0000090)2.79993968
56Palmar hyperkeratosis (HP:0010765)2.78920677
57Metabolic acidosis (HP:0001942)2.76162121
58Furrowed tongue (HP:0000221)2.74490895
59Congenital stationary night blindness (HP:0007642)2.74269505
60Aplasia/hypoplasia of the uterus (HP:0008684)2.73782461
61Onycholysis (HP:0001806)2.72802834
62Systemic lupus erythematosus (HP:0002725)2.71754120
63Skin nodule (HP:0200036)2.71552987
64Type II lissencephaly (HP:0007260)2.71405279
65Tubular atrophy (HP:0000092)2.68895389
66Vascular calcification (HP:0004934)2.68128853
67Abnormality of purine metabolism (HP:0004352)2.63143237
68Chronic hepatic failure (HP:0100626)2.62334504
69Alopecia of scalp (HP:0002293)2.62246815
70Dicarboxylic aciduria (HP:0003215)2.59455977
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59455977
72Abnormality of the renal medulla (HP:0100957)2.57871170
73Lethargy (HP:0001254)2.56828273
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.53937214
75Absent/shortened dynein arms (HP:0200106)2.53937214
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.50951519
77Abnormal gallbladder morphology (HP:0012437)2.49464938
78Abnormal gallbladder physiology (HP:0012438)2.47103308
79Cholecystitis (HP:0001082)2.47103308
80Acanthocytosis (HP:0001927)2.44000449
81Hypoglycemic seizures (HP:0002173)2.43010707
82Cholelithiasis (HP:0001081)2.42246804
83Attenuation of retinal blood vessels (HP:0007843)2.42075349
84Spastic diplegia (HP:0001264)2.41735941
85Amyloidosis (HP:0011034)2.41378669
86Glomerulonephritis (HP:0000099)2.40566797
87Medial flaring of the eyebrow (HP:0010747)2.38273218
88Malnutrition (HP:0004395)2.36863949
89Cardiovascular calcification (HP:0011915)2.36625825
90Mitral stenosis (HP:0001718)2.36392094
91Neonatal onset (HP:0003623)2.36363960
92Amelogenesis imperfecta (HP:0000705)2.36235508
93Cerebral edema (HP:0002181)2.36161686
94Irritability (HP:0000737)2.34184152
95Gout (HP:0001997)2.33608750
96Conjunctival hamartoma (HP:0100780)2.29770225
97Abolished electroretinogram (ERG) (HP:0000550)2.29619183
98Large for gestational age (HP:0001520)2.27381435
99Fair hair (HP:0002286)2.27086173
100Recurrent gram-negative bacterial infections (HP:0005420)2.23695764
101Chronic bronchitis (HP:0004469)2.20954141
102Hypotrichosis (HP:0001006)2.20904296
103Progressive inability to walk (HP:0002505)2.20500348
104Brushfield spots (HP:0001088)2.18165385
105Congenital, generalized hypertrichosis (HP:0004540)2.18116078
106Gingival bleeding (HP:0000225)2.17643791
107Abnormality of nail color (HP:0100643)2.17507940
108Hamartoma of the eye (HP:0010568)2.17426704
109Esophageal varix (HP:0002040)2.17036660
110Late onset (HP:0003584)2.16179770
111Polydipsia (HP:0001959)2.15691387
112Abnormal drinking behavior (HP:0030082)2.15691387
113Menorrhagia (HP:0000132)2.15409442
114Abnormality of the axillary hair (HP:0100134)2.14919874
115Abnormality of secondary sexual hair (HP:0009888)2.14919874
116Sensorimotor neuropathy (HP:0007141)2.14836342
117Woolly hair (HP:0002224)2.14111344
118Pancreatitis (HP:0001733)2.12444098
119Erythroderma (HP:0001019)2.12161724
120Hyperventilation (HP:0002883)2.11504473
121Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10548824
122Cystic liver disease (HP:0006706)2.10121598
123Abnormal hair laboratory examination (HP:0003328)2.09863073
124Inability to walk (HP:0002540)2.06947588
125Vomiting (HP:0002013)2.06945301
126Hyperactive renin-angiotensin system (HP:0000841)2.06939420
127Abnormality of renin-angiotensin system (HP:0000847)2.06273614
128Hemorrhage of the eye (HP:0011885)2.02672825
129Abnormality of the gallbladder (HP:0005264)2.02148636
130Thrombophlebitis (HP:0004418)2.01489851
131Opisthotonus (HP:0002179)2.01458123
132Rickets (HP:0002748)2.01249179
133Congenital ichthyosiform erythroderma (HP:0007431)2.00302106
134Enlarged kidneys (HP:0000105)1.99838863
135Pili torti (HP:0003777)1.99637006
136Duplicated collecting system (HP:0000081)1.98202206
137Fragile nails (HP:0001808)1.97268619
138Generalized aminoaciduria (HP:0002909)1.96985370
139Hypophosphatemic rickets (HP:0004912)1.96389208
140Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96353929
141Hyperinsulinemic hypoglycemia (HP:0000825)1.95925938
142Male pseudohermaphroditism (HP:0000037)1.95508946
143Hypoplastic labia majora (HP:0000059)1.94386932
144Widely spaced teeth (HP:0000687)1.94370028
145Abnormality of the renal collecting system (HP:0004742)1.92312912
146Abnormal rod and cone electroretinograms (HP:0008323)1.91643031
147Abnormal respiratory motile cilium physiology (HP:0012261)1.90144886
148Sex reversal (HP:0012245)1.88902013
149Abnormal sex determination (HP:0012244)1.88902013
150Stomach cancer (HP:0012126)1.88544470
151Poikilocytosis (HP:0004447)1.86673285
152Generalized hypopigmentation of hair (HP:0011358)1.86141563
153Abnormal respiratory motile cilium morphology (HP:0005938)1.85088909
154Abnormal respiratory epithelium morphology (HP:0012253)1.85088909
155Abnormality of iron homeostasis (HP:0011031)1.84177460
156Gaze-evoked nystagmus (HP:0000640)1.83783575
157Alkalosis (HP:0001948)1.83015422
158Abnormality of vitamin metabolism (HP:0100508)1.82578769
159Abnormality of transition element cation homeostasis (HP:0011030)1.81838336
160Hypoalbuminemia (HP:0003073)1.81571614
161Abnormal albumin level (HP:0012116)1.81571614
162Hydroxyprolinuria (HP:0003080)1.81451986
163Abnormality of proline metabolism (HP:0010907)1.81451986
164Concave nail (HP:0001598)1.81440689
165Cerebellar dysplasia (HP:0007033)1.81058720
166Abnormal cartilage morphology (HP:0002763)1.80799773
167Curly hair (HP:0002212)1.79590312
168Abnormality of DNA repair (HP:0003254)1.79067701
169Chorioretinal atrophy (HP:0000533)1.79056725
170Tongue fasciculations (HP:0001308)1.78870951
171Elevated hepatic transaminases (HP:0002910)1.78697033
172Abnormal ciliary motility (HP:0012262)1.78492970
173Dry hair (HP:0011359)1.78044340
174Increased CSF lactate (HP:0002490)1.77794393
175Abnormal enzyme/coenzyme activity (HP:0012379)1.77576150
176Bronchiectasis (HP:0002110)1.77403845
177Aplasia/Hypoplasia of the tongue (HP:0010295)1.75702137
178Hypomagnesemia (HP:0002917)1.75279767
179Milia (HP:0001056)1.74846736
180Lissencephaly (HP:0001339)1.74838118
181Renal cortical cysts (HP:0000803)1.73899234
182Status epilepticus (HP:0002133)1.73627204
183Hypoplasia of the uterus (HP:0000013)1.73596515
184Nephritis (HP:0000123)1.72649256
185Parakeratosis (HP:0001036)1.72329666
186Polyuria (HP:0000103)1.71735044
187Abnormality of the nasal septum (HP:0000419)1.70112148
188Right ventricular cardiomyopathy (HP:0011663)1.69248059
189Clubbing of toes (HP:0100760)1.68853562
190Rhinitis (HP:0012384)1.68731961
191Congenital primary aphakia (HP:0007707)1.68634318
192Pustule (HP:0200039)1.67660926
193Nephrogenic diabetes insipidus (HP:0009806)1.67327120
194Hepatic necrosis (HP:0002605)1.67281641
195Abnormality of the labia majora (HP:0012881)1.66573828
196Hyperglycemia (HP:0003074)1.66430216
197Mitochondrial inheritance (HP:0001427)1.66400310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.79168260
2SIK14.64095715
3FGFR44.54197157
4ERN14.44689584
5MST43.58538672
6MAP4K23.25965939
7TAOK33.01077789
8INSRR2.85988563
9ERBB42.81470371
10ADRBK22.69984165
11BMPR1B2.51236643
12MST1R2.48598269
13ACVR1B2.41938260
14MAP3K122.33740542
15MAP2K42.29351071
16MAPKAPK32.18352177
17STK392.13828074
18ZAK2.09767131
19PIK3CG1.98855590
20PKN21.98363488
21TRIB31.89867679
22MAPK111.80601845
23OXSR11.79516505
24WNK41.73619482
25LATS11.68699524
26TYK21.64684259
27MAP3K41.64661099
28FLT31.62974573
29FGFR21.61758784
30TXK1.59153679
31EPHA21.57279311
32EIF2AK31.50909715
33PTK61.50652271
34DAPK21.49492626
35TLK11.45534636
36FRK1.45335943
37BRSK21.44513522
38TGFBR11.41891021
39WNK31.41845190
40ABL21.37531193
41NLK1.33886919
42NME11.33668045
43TRPM71.31737210
44ERBB31.26303014
45NEK91.22025415
46EPHB11.21541214
47JAK21.18072360
48CASK1.15476625
49MAP3K71.15452326
50MAP2K71.15048768
51MAPK151.12806745
52PRKCE1.10868601
53TBK11.09957786
54PRKAA21.08357189
55PRKCI1.07572254
56MET1.06931917
57PIK3CA1.06311913
58KDR1.05003617
59MAP3K31.04939727
60GRK61.03521309
61MAP2K31.01584737
62ERBB21.01199819
63MAPK41.00638491
64IKBKB0.98543094
65ADRBK10.98420461
66TRIM280.97696603
67PINK10.97509014
68JAK10.97343697
69CAMKK20.96740533
70STK240.94398935
71TNIK0.90572566
72MAP3K140.87852443
73MAPK120.87591517
74PRKCZ0.86128524
75EPHA30.82169398
76CAMK2G0.79637627
77PASK0.79544335
78MAP3K100.79269067
79BCR0.78545168
80LMTK20.76548752
81STK30.76409951
82PRKACG0.74985329
83CDK60.72377791
84TIE10.71322387
85CAMK1D0.71267429
86MAP3K110.70097335
87EPHA40.69495784
88DYRK1B0.69330442
89CSK0.68558692
90MAP2K60.68388727
91GSK3A0.67766750
92DAPK10.67663102
93RIPK10.67525053
94TEC0.66305386
95GRK10.63731839
96PTK20.62718131
97IKBKE0.61978695
98STK38L0.61417348
99MAPK130.61106053
100PKN10.60199999
101IRAK10.59963613
102CHUK0.59958672
103PTK2B0.59416548
104MAPK70.58719864
105MAP4K10.57744144
106CSNK1G10.57656639
107PHKG10.57299935
108PHKG20.57299935
109SGK30.57245488
110BMPR20.57128223
111TGFBR20.56984046
112IRAK30.56791101
113PRKAA10.56471047
114PRKCQ0.56129213
115NEK60.55809016
116MUSK0.55667210
117PDPK10.55264817
118FGFR30.54447359
119TAF10.53935151
120RET0.50888989
121MAPKAPK50.47318358
122PBK0.46033411
123MAP2K10.45991707
124EIF2AK20.45251731
125PRKCH0.45021199
126CSF1R0.44979911
127MKNK20.44500986
128MAP3K20.44256203
129PRKD20.44089690
130VRK20.43775512
131IGF1R0.43412776
132SGK4940.41956816
133SGK2230.41956816
134SGK20.41908332
135CSNK1G30.41734237
136STK100.41082106
137PNCK0.40456745
138CSNK1G20.40053899
139STK110.39023197
140FER0.38962670
141RPS6KB20.38423916
142MAP3K130.36832815
143MAP3K60.36392458
144MAP2K20.33979709
145PDK10.33392293
146PAK30.33301109
147PRKCG0.33243726
148EGFR0.32064413
149MAP3K50.31715892
150MAP3K10.30741790
151ITK0.30157040
152TAOK20.29846594
153CSNK1A10.28735431
154CSNK1A1L0.28575759
155PRKCA0.28329408
156HIPK20.27706539
157ICK0.26909101
158CAMK40.26091285
159MTOR0.25689098
160CAMK1G0.24413991
161NTRK30.24185330
162ABL10.23959489
163EPHB20.23041973
164VRK10.22735786
165NUAK10.21941169

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.50689131
2Nitrogen metabolism_Homo sapiens_hsa009103.51231648
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31994926
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.22416982
5Arginine biosynthesis_Homo sapiens_hsa002202.98904107
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75229985
7Phototransduction_Homo sapiens_hsa047442.73119244
8Complement and coagulation cascades_Homo sapiens_hsa046102.70888436
9Tryptophan metabolism_Homo sapiens_hsa003802.67782956
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.64560184
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60586102
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51060475
13Fatty acid degradation_Homo sapiens_hsa000712.49706322
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40200573
15Protein export_Homo sapiens_hsa030602.23336609
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.22774750
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21713835
18Butanoate metabolism_Homo sapiens_hsa006502.15819713
19Peroxisome_Homo sapiens_hsa041462.07984159
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04067702
21Chemical carcinogenesis_Homo sapiens_hsa052042.01833322
22Histidine metabolism_Homo sapiens_hsa003402.01109758
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00757314
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98664198
25Propanoate metabolism_Homo sapiens_hsa006401.96206500
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.94430309
27PPAR signaling pathway_Homo sapiens_hsa033201.88303014
28Fatty acid metabolism_Homo sapiens_hsa012121.83464421
29Caffeine metabolism_Homo sapiens_hsa002321.80107637
30Retinol metabolism_Homo sapiens_hsa008301.79364101
31Staphylococcus aureus infection_Homo sapiens_hsa051501.73703345
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.73176548
33beta-Alanine metabolism_Homo sapiens_hsa004101.71812559
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69454078
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66696540
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61724615
37Phenylalanine metabolism_Homo sapiens_hsa003601.59042014
38Selenocompound metabolism_Homo sapiens_hsa004501.50226901
39Bile secretion_Homo sapiens_hsa049761.49179725
40Tyrosine metabolism_Homo sapiens_hsa003501.48616671
41Fatty acid elongation_Homo sapiens_hsa000621.47287388
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45836203
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45070690
44Sulfur metabolism_Homo sapiens_hsa009201.41208238
45Basal transcription factors_Homo sapiens_hsa030221.38713641
46Homologous recombination_Homo sapiens_hsa034401.38294386
47Pyruvate metabolism_Homo sapiens_hsa006201.36087587
48Type I diabetes mellitus_Homo sapiens_hsa049401.30003104
49Steroid biosynthesis_Homo sapiens_hsa001001.28393689
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.25854390
51Starch and sucrose metabolism_Homo sapiens_hsa005001.25006541
52ABC transporters_Homo sapiens_hsa020101.22370444
53Folate biosynthesis_Homo sapiens_hsa007901.21094999
54Fat digestion and absorption_Homo sapiens_hsa049751.19262386
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.18747896
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17963294
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15027773
58Biosynthesis of amino acids_Homo sapiens_hsa012301.13687770
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.11042501
60Carbon metabolism_Homo sapiens_hsa012001.08869551
61Circadian rhythm_Homo sapiens_hsa047101.04740791
62Primary immunodeficiency_Homo sapiens_hsa053401.04317741
63Oxidative phosphorylation_Homo sapiens_hsa001901.01015751
64RNA polymerase_Homo sapiens_hsa030201.00829032
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99077064
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.97699832
67Arginine and proline metabolism_Homo sapiens_hsa003300.94407992
68Sphingolipid metabolism_Homo sapiens_hsa006000.94329555
69RNA degradation_Homo sapiens_hsa030180.93956209
70Sulfur relay system_Homo sapiens_hsa041220.93257559
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92162587
72Olfactory transduction_Homo sapiens_hsa047400.91686607
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88992855
74Vitamin B6 metabolism_Homo sapiens_hsa007500.88582963
75Collecting duct acid secretion_Homo sapiens_hsa049660.87649534
76Vitamin digestion and absorption_Homo sapiens_hsa049770.85541322
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83200541
78Mineral absorption_Homo sapiens_hsa049780.82645201
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81247392
80Proteasome_Homo sapiens_hsa030500.79497386
81Dorso-ventral axis formation_Homo sapiens_hsa043200.76867055
82Insulin secretion_Homo sapiens_hsa049110.74472077
83Lysine degradation_Homo sapiens_hsa003100.74399812
84Serotonergic synapse_Homo sapiens_hsa047260.73016913
85Glycerolipid metabolism_Homo sapiens_hsa005610.70076859
86Fanconi anemia pathway_Homo sapiens_hsa034600.69756016
87Glutathione metabolism_Homo sapiens_hsa004800.69547686
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68374992
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63676399
90One carbon pool by folate_Homo sapiens_hsa006700.61887483
91Fatty acid biosynthesis_Homo sapiens_hsa000610.60615170
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60215182
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59030204
94Taste transduction_Homo sapiens_hsa047420.56435975
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56032700
96Pentose phosphate pathway_Homo sapiens_hsa000300.55223571
97Pancreatic secretion_Homo sapiens_hsa049720.52857367
98Graft-versus-host disease_Homo sapiens_hsa053320.52520719
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52249612
100Metabolic pathways_Homo sapiens_hsa011000.46524755
101Salivary secretion_Homo sapiens_hsa049700.45672429
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40725576
103Purine metabolism_Homo sapiens_hsa002300.38383775
104Pyrimidine metabolism_Homo sapiens_hsa002400.38066274
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37724488
106p53 signaling pathway_Homo sapiens_hsa041150.36245621
107Autoimmune thyroid disease_Homo sapiens_hsa053200.34820501
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34626989
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34549549
110Prion diseases_Homo sapiens_hsa050200.34426821
111Non-homologous end-joining_Homo sapiens_hsa034500.33950326
112Linoleic acid metabolism_Homo sapiens_hsa005910.31665838
113Allograft rejection_Homo sapiens_hsa053300.30629928
114Huntingtons disease_Homo sapiens_hsa050160.30264870
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29904117
116N-Glycan biosynthesis_Homo sapiens_hsa005100.29109798
117Long-term depression_Homo sapiens_hsa047300.27201652
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25782708
119Asthma_Homo sapiens_hsa053100.25707557
120Parkinsons disease_Homo sapiens_hsa050120.25625512
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.23163062
122Galactose metabolism_Homo sapiens_hsa000520.22278431
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.22179130
124Insulin resistance_Homo sapiens_hsa049310.22081775
125Fructose and mannose metabolism_Homo sapiens_hsa000510.21860619
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.19335962
127Glucagon signaling pathway_Homo sapiens_hsa049220.08736674
128AMPK signaling pathway_Homo sapiens_hsa041520.00068157
129Bladder cancer_Homo sapiens_hsa05219-0.2387005
130Pertussis_Homo sapiens_hsa05133-0.2366565
131Amoebiasis_Homo sapiens_hsa05146-0.2258899
132Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2258408
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2134746
134Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2122724
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2111495
136Renin-angiotensin system_Homo sapiens_hsa04614-0.1958970
137Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1762620
138Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1695673
139Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1644254
140Ether lipid metabolism_Homo sapiens_hsa00565-0.1625445
141Hepatitis C_Homo sapiens_hsa05160-0.1595894
142African trypanosomiasis_Homo sapiens_hsa05143-0.1335567
143Regulation of autophagy_Homo sapiens_hsa04140-0.1293423
144Insulin signaling pathway_Homo sapiens_hsa04910-0.1244941
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1021624
146Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1001307
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0956425
148Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0444364
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0093964

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