SDR42E2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.11412995
2response to pheromone (GO:0019236)5.42950085
3regulation of chronic inflammatory response (GO:0002676)5.06688050
4axonemal dynein complex assembly (GO:0070286)5.05405668
5regulation of isotype switching to IgG isotypes (GO:0048302)5.03404001
6tolerance induction (GO:0002507)4.78012790
7positive regulation of granulocyte differentiation (GO:0030854)4.57025118
8regulation of B cell receptor signaling pathway (GO:0050855)4.51250888
9regulation of regulatory T cell differentiation (GO:0045589)4.45362104
10negative T cell selection (GO:0043383)4.19320390
11axon ensheathment in central nervous system (GO:0032291)4.05109395
12central nervous system myelination (GO:0022010)4.05109395
13negative thymic T cell selection (GO:0045060)4.02987162
14cell wall macromolecule catabolic process (GO:0016998)3.82189941
15regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.80922603
16epithelial cilium movement (GO:0003351)3.79061767
17adaptation of signaling pathway (GO:0023058)3.74111231
18cilium or flagellum-dependent cell motility (GO:0001539)3.67098836
19sleep (GO:0030431)3.60861180
20cilium movement (GO:0003341)3.50945280
21negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.50921002
22regulation of T cell mediated cytotoxicity (GO:0001914)3.50311382
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.48459050
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.46827876
25axoneme assembly (GO:0035082)3.44509870
26regulation of T cell receptor signaling pathway (GO:0050856)3.42912393
27negative regulation of acute inflammatory response (GO:0002674)3.42377225
28mitotic cell cycle arrest (GO:0071850)3.36866268
29positive regulation of T cell differentiation in thymus (GO:0033089)3.32873055
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31079456
31negative regulation of astrocyte differentiation (GO:0048712)3.30569960
32negative regulation of oligodendrocyte differentiation (GO:0048715)3.29660568
33cell wall macromolecule metabolic process (GO:0044036)3.29080776
34rRNA catabolic process (GO:0016075)3.25025112
35regulation of mitotic spindle checkpoint (GO:1903504)3.24916488
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24916488
37sequestering of actin monomers (GO:0042989)3.23888758
38negative regulation of interleukin-1 beta production (GO:0032691)3.19604268
39cellular response to interleukin-15 (GO:0071350)3.19366780
40regulation of leukocyte mediated cytotoxicity (GO:0001910)3.17004927
41T-helper cell differentiation (GO:0042093)3.15310705
42CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.15310705
43DNA deamination (GO:0045006)3.14838778
44regulation of cilium movement (GO:0003352)3.12728357
45positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11172916
46negative regulation of T cell receptor signaling pathway (GO:0050860)3.09698329
47positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.09224224
48peptidyl-threonine dephosphorylation (GO:0035970)3.08572941
49endoderm formation (GO:0001706)3.07749427
50gamma-aminobutyric acid transport (GO:0015812)3.06971993
51synaptonemal complex organization (GO:0070193)3.04112706
52regulation of cell killing (GO:0031341)3.02030313
53positive regulation of natural killer cell mediated immunity (GO:0002717)2.95446987
54positive regulation of cell killing (GO:0031343)2.95222997
55synaptonemal complex assembly (GO:0007130)2.93057805
56positive regulation of defense response to virus by host (GO:0002230)2.92776777
57regulation of gamma-delta T cell differentiation (GO:0045586)2.90185473
58positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.86755462
59sulfation (GO:0051923)2.84148997
60autophagic vacuole fusion (GO:0000046)2.83332375
61T cell differentiation involved in immune response (GO:0002292)2.78737867
62alpha-beta T cell differentiation involved in immune response (GO:0002293)2.78737867
63alpha-beta T cell activation involved in immune response (GO:0002287)2.78737867
64positive regulation of oligodendrocyte differentiation (GO:0048714)2.77322834
65regulation of granulocyte differentiation (GO:0030852)2.76383433
66positive T cell selection (GO:0043368)2.76339088
67positive regulation of tolerance induction (GO:0002645)2.75611136
68protein localization to cilium (GO:0061512)2.75479531
69behavioral response to nicotine (GO:0035095)2.75344797
70positive regulation of gamma-delta T cell activation (GO:0046645)2.71749554
71regulation of MHC class II biosynthetic process (GO:0045346)2.70720173
72thymic T cell selection (GO:0045061)2.70337048
73organelle membrane fusion (GO:0090174)2.69634514
74lymphocyte costimulation (GO:0031294)2.66181596
75T cell migration (GO:0072678)2.66103464
76positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.65387838
77regulation of glycogen (starch) synthase activity (GO:2000465)2.62599850
78positive regulation of DNA recombination (GO:0045911)2.60819283
79regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.60412307
80chemokine-mediated signaling pathway (GO:0070098)2.59724795
81positive thymic T cell selection (GO:0045059)2.58477329
82regulation of alpha-beta T cell proliferation (GO:0046640)2.57639448
83regulation of T cell differentiation in thymus (GO:0033081)2.57531161
84T cell differentiation (GO:0030217)2.56460235
85regulation of T cell tolerance induction (GO:0002664)2.55804209
86leukocyte aggregation (GO:0070486)2.55116228
87CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.53540569
88positive regulation of alpha-beta T cell proliferation (GO:0046641)2.52099270
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.50473301
90T cell receptor signaling pathway (GO:0050852)2.50159645
91one-carbon compound transport (GO:0019755)2.50019850
92alpha-beta T cell differentiation (GO:0046632)2.49500496
93negative regulation of interleukin-1 production (GO:0032692)2.46576495
94actin nucleation (GO:0045010)2.45996446
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.44228782
96positive regulation of calcium-mediated signaling (GO:0050850)2.43929583
97T cell costimulation (GO:0031295)2.43165500
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42500628
99dopaminergic neuron differentiation (GO:0071542)2.41941214
100regulation of natural killer cell mediated immunity (GO:0002715)2.41821693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.85799633
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.47680139
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.42140613
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05867234
5RUNX_20019798_ChIP-Seq_JUKART_Human2.61173594
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56744172
7VDR_22108803_ChIP-Seq_LS180_Human2.46577046
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44652687
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.31109818
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.30918661
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.02135989
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97336248
13PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93416288
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90052921
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77681631
16GBX2_23144817_ChIP-Seq_PC3_Human1.74951354
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73756209
18ZNF274_21170338_ChIP-Seq_K562_Hela1.73676160
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73361536
20AR_21572438_ChIP-Seq_LNCaP_Human1.69208431
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67203706
22MYB_26560356_Chip-Seq_TH2_Human1.67055789
23EWS_26573619_Chip-Seq_HEK293_Human1.60180076
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58904247
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56913215
26P300_19829295_ChIP-Seq_ESCs_Human1.56337224
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.55652050
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52818434
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52374019
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51950682
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49812881
32TAF15_26573619_Chip-Seq_HEK293_Human1.49322382
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.48212433
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47841923
35FUS_26573619_Chip-Seq_HEK293_Human1.45977069
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45025026
37GATA3_26560356_Chip-Seq_TH2_Human1.43500934
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.40768725
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37819881
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31906933
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31741595
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.31649660
43ER_23166858_ChIP-Seq_MCF-7_Human1.29413275
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28209867
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27387396
46BCAT_22108803_ChIP-Seq_LS180_Human1.26751677
47GATA3_27048872_Chip-Seq_THYMUS_Human1.26295012
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.23646211
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20652921
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20308742
51AR_20517297_ChIP-Seq_VCAP_Human1.20248941
52MYC_18940864_ChIP-ChIP_HL60_Human1.20031003
53TCF4_22108803_ChIP-Seq_LS180_Human1.19994648
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18739336
55RNF2_27304074_Chip-Seq_NSC_Mouse1.18537099
56AR_25329375_ChIP-Seq_VCAP_Human1.18253629
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.12779438
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11953605
59IGF1R_20145208_ChIP-Seq_DFB_Human1.09799878
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09538286
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.08478567
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08478567
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08003557
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.07323510
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06114968
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05817373
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.04651408
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04564157
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04226682
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04163147
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.03297814
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03061806
73TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02939495
74SMAD4_21799915_ChIP-Seq_A2780_Human1.02194914
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.01504566
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01006595
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00811059
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00696725
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99969972
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99780589
81CBP_20019798_ChIP-Seq_JUKART_Human0.99780589
82P53_22387025_ChIP-Seq_ESCs_Mouse0.99626841
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99160741
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98348480
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97905370
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.97297096
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96783500
88SOX2_19829295_ChIP-Seq_ESCs_Human0.96711267
89NANOG_19829295_ChIP-Seq_ESCs_Human0.96711267
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96328254
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96210270
92ETV1_20927104_ChIP-Seq_GIST48_Human0.95445476
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94679098
94OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94522995
95JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94132961
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94066543
97TP53_22573176_ChIP-Seq_HFKS_Human0.93908058
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93091088
99DROSHA_22980978_ChIP-Seq_HELA_Human0.92570771
100TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92235257

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.03564032
2MP0003724_increased_susceptibility_to2.83423857
3MP0001873_stomach_inflammation2.81026579
4MP0005423_abnormal_somatic_nervous2.80650505
5MP0002009_preneoplasia2.77938226
6MP0004885_abnormal_endolymph2.69906266
7MP0001986_abnormal_taste_sensitivity2.63988674
8MP0003136_yellow_coat_color2.61696815
9MP0003436_decreased_susceptibility_to2.32101112
10MP0006072_abnormal_retinal_apoptosis2.30184180
11MP0003195_calcinosis2.27873504
12MP0005000_abnormal_immune_tolerance2.19201182
13MP0001835_abnormal_antigen_presentation2.15478219
14MP0001501_abnormal_sleep_pattern2.07378777
15MP0002933_joint_inflammation2.06168365
16MP0008877_abnormal_DNA_methylation2.03072056
17MP0005410_abnormal_fertilization2.01294895
18MP0004742_abnormal_vestibular_system2.00746795
19MP0001800_abnormal_humoral_immune1.98606509
20MP0002166_altered_tumor_susceptibility1.98533485
21MP0002277_abnormal_respiratory_mucosa1.94493396
22MP0008875_abnormal_xenobiotic_pharmacok1.92205163
23MP0003763_abnormal_thymus_physiology1.73590636
24MP0009785_altered_susceptibility_to1.72230488
25MP0002723_abnormal_immune_serum1.64556724
26MP0005377_hearing/vestibular/ear_phenot1.59087922
27MP0003878_abnormal_ear_physiology1.59087922
28MP0001348_abnormal_lacrimal_gland1.58990521
29MP0002653_abnormal_ependyma_morphology1.54522591
30MP0005310_abnormal_salivary_gland1.52802517
31MP0003011_delayed_dark_adaptation1.51446533
32MP0005253_abnormal_eye_physiology1.49814819
33MP0002006_tumorigenesis1.48804467
34MP0005551_abnormal_eye_electrophysiolog1.46978956
35MP0001819_abnormal_immune_cell1.46408833
36MP0002452_abnormal_antigen_presenting1.46040065
37MP0002420_abnormal_adaptive_immunity1.45659189
38MP0003866_abnormal_defecation1.37281022
39MP0009745_abnormal_behavioral_response1.35604905
40MP0001486_abnormal_startle_reflex1.27442163
41MP0008995_early_reproductive_senescence1.24752417
42MP0001905_abnormal_dopamine_level1.23552197
43MP0001919_abnormal_reproductive_system1.22408257
44MP0004142_abnormal_muscle_tone1.21088839
45MP0003646_muscle_fatigue1.20581600
46MP0006082_CNS_inflammation1.19077816
47MP0005025_abnormal_response_to1.18816087
48MP0000465_gastrointestinal_hemorrhage1.18544628
49MP0002272_abnormal_nervous_system1.16165412
50MP0001968_abnormal_touch/_nociception1.14628136
51MP0003880_abnormal_central_pattern1.10938656
52MP0001984_abnormal_olfaction1.10660026
53MP0002693_abnormal_pancreas_physiology1.09782123
54MP0000026_abnormal_inner_ear1.08857770
55MP0005360_urolithiasis1.06887946
56MP0005645_abnormal_hypothalamus_physiol1.06752181
57MP0005389_reproductive_system_phenotype1.06732385
58MP0000685_abnormal_immune_system1.05415332
59MP0002638_abnormal_pupillary_reflex1.05341809
60MP0004147_increased_porphyrin_level1.05339714
61MP0000383_abnormal_hair_follicle1.04910266
62MP0002837_dystrophic_cardiac_calcinosis1.02248874
63MP0008058_abnormal_DNA_repair1.01504541
64MP0004145_abnormal_muscle_electrophysio1.00959485
65MP0005387_immune_system_phenotype1.00196064
66MP0001790_abnormal_immune_system1.00196064
67MP0000716_abnormal_immune_system0.98636155
68MP0002102_abnormal_ear_morphology0.97660665
69MP0002405_respiratory_system_inflammati0.96375531
70MP0002064_seizures0.95670777
71MP0001963_abnormal_hearing_physiology0.94836946
72MP0002557_abnormal_social/conspecific_i0.94562549
73MP0001533_abnormal_skeleton_physiology0.94295405
74MP0002139_abnormal_hepatobiliary_system0.94250920
75MP0002572_abnormal_emotion/affect_behav0.93906392
76MP0005167_abnormal_blood-brain_barrier0.93903155
77MP0001845_abnormal_inflammatory_respons0.93365512
78MP0001929_abnormal_gametogenesis0.92522790
79MP0002419_abnormal_innate_immunity0.89417920
80MP0000703_abnormal_thymus_morphology0.88208415
81MP0002148_abnormal_hypersensitivity_rea0.87680603
82MP0003638_abnormal_response/metabolism_0.87601812
83MP0001970_abnormal_pain_threshold0.87096900
84MP0006276_abnormal_autonomic_nervous0.86139554
85MP0002733_abnormal_thermal_nociception0.85795568
86MP0008872_abnormal_physiological_respon0.84896436
87MP0005085_abnormal_gallbladder_physiolo0.84588671
88MP0000372_irregular_coat_pigmentation0.84080977
89MP0002160_abnormal_reproductive_system0.82894854
90MP0002398_abnormal_bone_marrow0.81680162
91MP0003698_abnormal_male_reproductive0.80957837
92MP0002751_abnormal_autonomic_nervous0.80098839
93MP0000689_abnormal_spleen_morphology0.79614731
94MP0001765_abnormal_ion_homeostasis0.79343206
95MP0002876_abnormal_thyroid_physiology0.77746544
96MP0001853_heart_inflammation0.76312012
97MP0005646_abnormal_pituitary_gland0.76247010
98MP0003635_abnormal_synaptic_transmissio0.73888467
99MP0004381_abnormal_hair_follicle0.73864113
100MP0002735_abnormal_chemical_nociception0.72718361

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.04368692
2Absent/shortened dynein arms (HP:0200106)5.51548325
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.51548325
4Abnormal respiratory motile cilium physiology (HP:0012261)4.86628212
5Abnormal respiratory epithelium morphology (HP:0012253)4.56544527
6Abnormal respiratory motile cilium morphology (HP:0005938)4.56544527
7Abnormal ciliary motility (HP:0012262)4.08701661
8Pancreatic cysts (HP:0001737)3.86601874
9IgG deficiency (HP:0004315)3.78082410
10Stomach cancer (HP:0012126)3.77551295
11Rhinitis (HP:0012384)3.56420927
12Chronic bronchitis (HP:0004469)3.32584515
13True hermaphroditism (HP:0010459)3.32563594
14Pancreatic fibrosis (HP:0100732)3.27674412
15Congenital stationary night blindness (HP:0007642)3.24904890
16Severe combined immunodeficiency (HP:0004430)2.97657714
17Absent rod-and cone-mediated responses on ERG (HP:0007688)2.96978085
18Abnormality of the renal cortex (HP:0011035)2.86150235
19Bronchiectasis (HP:0002110)2.82013651
20Increased hepatocellular lipid droplets (HP:0006565)2.79550296
21Abnormal rod and cone electroretinograms (HP:0008323)2.74549088
22Renal Fanconi syndrome (HP:0001994)2.70949394
23Renal cortical cysts (HP:0000803)2.70497811
24Abnormality of midbrain morphology (HP:0002418)2.69437604
25Molar tooth sign on MRI (HP:0002419)2.69437604
26Prostate neoplasm (HP:0100787)2.66176900
27Cystic liver disease (HP:0006706)2.62169048
28Abnormality of the prostate (HP:0008775)2.61525226
29Aplastic anemia (HP:0001915)2.56996843
30Bronchitis (HP:0012387)2.56064547
31Nephronophthisis (HP:0000090)2.52546480
32Elevated erythrocyte sedimentation rate (HP:0003565)2.48883010
33Infertility (HP:0000789)2.45604130
34Lipid accumulation in hepatocytes (HP:0006561)2.43522755
35Abnormal drinking behavior (HP:0030082)2.43407460
36Polydipsia (HP:0001959)2.43407460
37Large for gestational age (HP:0001520)2.39118518
38Thyroiditis (HP:0100646)2.38536930
39Hemiplegia (HP:0002301)2.37091289
40Decreased central vision (HP:0007663)2.34605527
41Limb dystonia (HP:0002451)2.33076751
42Acute necrotizing encephalopathy (HP:0006965)2.32539200
43Medial flaring of the eyebrow (HP:0010747)2.32255440
44Hypoproteinemia (HP:0003075)2.32093567
45Focal motor seizures (HP:0011153)2.30560555
46Stomatitis (HP:0010280)2.28593787
47Mitochondrial inheritance (HP:0001427)2.25091286
48Progressive cerebellar ataxia (HP:0002073)2.23784683
49Attenuation of retinal blood vessels (HP:0007843)2.22167011
50Recurrent sinusitis (HP:0011108)2.21870022
51T lymphocytopenia (HP:0005403)2.20021979
52Furrowed tongue (HP:0000221)2.19325719
53Combined immunodeficiency (HP:0005387)2.16483363
54Abnormality of T cell number (HP:0011839)2.12415977
55Gait imbalance (HP:0002141)2.11010285
56Progressive macrocephaly (HP:0004481)2.07735885
57Abnormality of the renal medulla (HP:0100957)2.07079590
58Recurrent bronchitis (HP:0002837)2.03457068
59Recurrent otitis media (HP:0000403)2.03121544
60Exertional dyspnea (HP:0002875)2.00969400
61Congenital, generalized hypertrichosis (HP:0004540)1.99841648
62Arthropathy (HP:0003040)1.99503795
63Abnormality of male internal genitalia (HP:0000022)1.98029527
64Nephrogenic diabetes insipidus (HP:0009806)1.96993335
65Congenital primary aphakia (HP:0007707)1.96658895
66Abnormal mitochondria in muscle tissue (HP:0008316)1.96379038
67Papilledema (HP:0001085)1.93305254
68Anhidrosis (HP:0000970)1.92337497
69Chronic sinusitis (HP:0011109)1.91387502
70Abnormal albumin level (HP:0012116)1.91322390
71Hypoalbuminemia (HP:0003073)1.91322390
72Genital tract atresia (HP:0001827)1.89825598
73Tubular atrophy (HP:0000092)1.88176777
74Rib fusion (HP:0000902)1.86730585
75Abnormality of renal resorption (HP:0011038)1.86267643
76Polyuria (HP:0000103)1.86198669
77Bone cyst (HP:0012062)1.86002115
78Panhypogammaglobulinemia (HP:0003139)1.84177599
79Abnormality of DNA repair (HP:0003254)1.82649846
80Fibular aplasia (HP:0002990)1.82505378
81Sclerocornea (HP:0000647)1.81846590
82Glycosuria (HP:0003076)1.80609966
83Abnormality of urine glucose concentration (HP:0011016)1.80609966
84Nasal polyposis (HP:0100582)1.80339779
85Vaginal atresia (HP:0000148)1.79940367
86Increased CSF lactate (HP:0002490)1.77894503
87Postaxial foot polydactyly (HP:0001830)1.75410795
88Abnormality of the diencephalon (HP:0010662)1.74833957
89Abnormality of T cells (HP:0002843)1.73422374
90Hemoptysis (HP:0002105)1.70580473
91Chronic hepatic failure (HP:0100626)1.70545688
92Generalized aminoaciduria (HP:0002909)1.68619238
93Male pseudohermaphroditism (HP:0000037)1.68477709
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67050249
95Abnormality of the pons (HP:0007361)1.65259031
96Recurrent fungal infections (HP:0002841)1.64317023
97Hemiparesis (HP:0001269)1.63494032
98Optic disc pallor (HP:0000543)1.62093294
99Increased intramyocellular lipid droplets (HP:0012240)1.62029157
100Postaxial hand polydactyly (HP:0001162)1.61646262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.22942583
2TAOK34.56541140
3TLK14.00693028
4MAP2K22.92091416
5MAPK152.91645623
6TESK22.66159135
7WNK42.44126686
8ZAK2.22052532
9GRK62.10937656
10VRK12.04934618
11FES1.98389111
12FRK1.92016671
13WNK31.87939257
14PNCK1.80225732
15PASK1.78098525
16CAMKK21.77437020
17PTK2B1.74753271
18SYK1.58309958
19CASK1.51230443
20CDK191.48993497
21ITK1.48302178
22NME11.47625407
23ADRBK21.43409259
24KDR1.43386254
25GRK11.34344912
26ERBB31.29275914
27CAMKK11.28460630
28MATK1.14908357
29CSK1.13150297
30PIM11.06690715
31IKBKB1.05000000
32MAP3K21.04342247
33STK391.03967188
34WNK11.03923767
35MAP4K21.03876863
36LCK1.03239180
37TRPM71.02331527
38ERBB20.99789748
39NTRK10.99380974
40IKBKE0.98971237
41ZAP700.98631562
42JAK10.97271079
43LYN0.91262874
44TBK10.90864550
45INSRR0.86460907
46GRK70.85178222
47TEC0.84932412
48PRKCQ0.83114286
49MAP3K140.80844795
50TYK20.80252114
51JAK30.79966587
52MAPK130.74774299
53NTRK20.73968397
54PHKG20.73013322
55PHKG10.73013322
56PBK0.72107412
57DAPK20.70944266
58MAP4K10.68246057
59NTRK30.65611036
60CSF1R0.63935480
61PRKCG0.61759834
62EIF2AK20.61045378
63TYRO30.60913621
64IGF1R0.60423356
65PAK30.59520405
66AKT30.56948706
67PKN10.54489789
68MAP3K50.54176414
69ADRBK10.53671212
70NUAK10.51706461
71MAP2K10.51181788
72RPS6KA50.50831419
73BMPR20.50563614
74WEE10.49601280
75LIMK10.49366019
76BRSK20.49141159
77MAPK70.48999277
78GRK50.48571409
79BTK0.45278707
80NLK0.44395139
81UHMK10.44217070
82MST40.42801235
83TSSK60.39757635
84CAMK2A0.39683910
85MAP2K60.37838809
86ROCK10.37435428
87CAMK40.37275569
88PIK3CG0.37069311
89MKNK20.36450577
90TNIK0.36321172
91BLK0.36289241
92INSR0.35144266
93BRD40.33590874
94MAPKAPK20.33269842
95KIT0.32331994
96STK40.32271270
97MAP3K40.32236053
98EPHA30.31968736
99PLK20.30151384
100PRKACA0.29413001

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053203.69129069
2Primary immunodeficiency_Homo sapiens_hsa053403.45909038
3Allograft rejection_Homo sapiens_hsa053303.41198705
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.20727458
5Asthma_Homo sapiens_hsa053102.96327182
6Protein export_Homo sapiens_hsa030602.83838617
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.63866395
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38584087
9Graft-versus-host disease_Homo sapiens_hsa053322.35266865
10T cell receptor signaling pathway_Homo sapiens_hsa046602.30743754
11Oxidative phosphorylation_Homo sapiens_hsa001902.14007557
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13832884
13Antigen processing and presentation_Homo sapiens_hsa046121.87008171
14Nitrogen metabolism_Homo sapiens_hsa009101.86512749
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80698498
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.77122612
17Hematopoietic cell lineage_Homo sapiens_hsa046401.76965809
18RNA polymerase_Homo sapiens_hsa030201.75465933
19Type I diabetes mellitus_Homo sapiens_hsa049401.73665221
20Nicotine addiction_Homo sapiens_hsa050331.57520153
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57003505
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38950944
23Taste transduction_Homo sapiens_hsa047421.36307398
24Rheumatoid arthritis_Homo sapiens_hsa053231.35708587
25Ribosome_Homo sapiens_hsa030101.34828713
26Parkinsons disease_Homo sapiens_hsa050121.34807291
27Phototransduction_Homo sapiens_hsa047441.30479465
28GABAergic synapse_Homo sapiens_hsa047271.29289539
29Collecting duct acid secretion_Homo sapiens_hsa049661.19502823
30Olfactory transduction_Homo sapiens_hsa047401.15992213
31Cardiac muscle contraction_Homo sapiens_hsa042601.15463349
32Amphetamine addiction_Homo sapiens_hsa050311.14935418
33Morphine addiction_Homo sapiens_hsa050321.14523255
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09312256
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.08116173
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06237262
37Linoleic acid metabolism_Homo sapiens_hsa005911.02539456
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02486404
39Basal transcription factors_Homo sapiens_hsa030221.00410869
40Malaria_Homo sapiens_hsa051440.99826620
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94086606
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92982416
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91957192
44Butanoate metabolism_Homo sapiens_hsa006500.91289087
45Huntingtons disease_Homo sapiens_hsa050160.87496278
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.87312727
47Serotonergic synapse_Homo sapiens_hsa047260.86323516
48Glutamatergic synapse_Homo sapiens_hsa047240.85071821
49Measles_Homo sapiens_hsa051620.84631025
50RNA degradation_Homo sapiens_hsa030180.83426932
51Chemical carcinogenesis_Homo sapiens_hsa052040.83219314
52Alzheimers disease_Homo sapiens_hsa050100.78389545
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.77862090
54Regulation of autophagy_Homo sapiens_hsa041400.77195667
55Systemic lupus erythematosus_Homo sapiens_hsa053220.77108833
56Caffeine metabolism_Homo sapiens_hsa002320.76041339
57Retinol metabolism_Homo sapiens_hsa008300.75644369
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74187511
59Circadian entrainment_Homo sapiens_hsa047130.72814838
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.72480383
61MAPK signaling pathway_Homo sapiens_hsa040100.68691415
62Salivary secretion_Homo sapiens_hsa049700.68362881
63Renin secretion_Homo sapiens_hsa049240.67711636
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66036431
65Chemokine signaling pathway_Homo sapiens_hsa040620.65597438
66Staphylococcus aureus infection_Homo sapiens_hsa051500.65424488
67Leishmaniasis_Homo sapiens_hsa051400.64331764
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63669763
69Viral myocarditis_Homo sapiens_hsa054160.58525482
70cAMP signaling pathway_Homo sapiens_hsa040240.58191952
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58120059
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57889327
73Calcium signaling pathway_Homo sapiens_hsa040200.54611731
74B cell receptor signaling pathway_Homo sapiens_hsa046620.52900168
75Mineral absorption_Homo sapiens_hsa049780.51999931
76TNF signaling pathway_Homo sapiens_hsa046680.51542843
77Cholinergic synapse_Homo sapiens_hsa047250.48009767
78ABC transporters_Homo sapiens_hsa020100.47818555
79Sulfur metabolism_Homo sapiens_hsa009200.45119004
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42951329
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42593760
82Dopaminergic synapse_Homo sapiens_hsa047280.40730140
83Oxytocin signaling pathway_Homo sapiens_hsa049210.38514727
84Circadian rhythm_Homo sapiens_hsa047100.37461514
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37430975
86Peroxisome_Homo sapiens_hsa041460.35521490
87Glycerolipid metabolism_Homo sapiens_hsa005610.34103778
88Herpes simplex infection_Homo sapiens_hsa051680.33983872
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32904697
90Cocaine addiction_Homo sapiens_hsa050300.32633080
91Tryptophan metabolism_Homo sapiens_hsa003800.31823096
92Alcoholism_Homo sapiens_hsa050340.30892426
93Histidine metabolism_Homo sapiens_hsa003400.29451974
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28873744
95Tyrosine metabolism_Homo sapiens_hsa003500.28526379
96Phenylalanine metabolism_Homo sapiens_hsa003600.27388905
97Vitamin digestion and absorption_Homo sapiens_hsa049770.26597128
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25463702
99Arachidonic acid metabolism_Homo sapiens_hsa005900.24918122
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23241955

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