SDS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.80234224
2L-phenylalanine catabolic process (GO:0006559)7.80234224
3omega-hydroxylase P450 pathway (GO:0097267)7.57877268
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.47369112
5L-phenylalanine metabolic process (GO:0006558)7.47369112
6epoxygenase P450 pathway (GO:0019373)7.42099949
7aromatic amino acid family catabolic process (GO:0009074)7.00746018
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.31820310
9indole-containing compound catabolic process (GO:0042436)6.31046136
10indolalkylamine catabolic process (GO:0046218)6.31046136
11tryptophan catabolic process (GO:0006569)6.31046136
12kynurenine metabolic process (GO:0070189)6.12443659
13bile acid biosynthetic process (GO:0006699)5.94692109
14urea cycle (GO:0000050)5.94542619
15urea metabolic process (GO:0019627)5.94542619
16tryptophan metabolic process (GO:0006568)5.92412949
17glyoxylate metabolic process (GO:0046487)5.72643880
18high-density lipoprotein particle remodeling (GO:0034375)5.56075283
19negative regulation of fibrinolysis (GO:0051918)5.54806708
20alpha-linolenic acid metabolic process (GO:0036109)5.48195150
21nitrogen cycle metabolic process (GO:0071941)5.46737026
22protein carboxylation (GO:0018214)5.37646976
23peptidyl-glutamic acid carboxylation (GO:0017187)5.37646976
24sulfur amino acid catabolic process (GO:0000098)5.37291013
25regulation of fibrinolysis (GO:0051917)5.36408756
26complement activation, alternative pathway (GO:0006957)5.33990893
27regulation of protein activation cascade (GO:2000257)5.32850281
28cysteine metabolic process (GO:0006534)5.31692458
29aromatic amino acid family metabolic process (GO:0009072)5.08942252
30bile acid metabolic process (GO:0008206)5.06242088
31oxidative demethylation (GO:0070989)5.02530136
32drug metabolic process (GO:0017144)5.01584700
33tyrosine metabolic process (GO:0006570)4.98394280
34regulation of complement activation (GO:0030449)4.96954163
35regulation of triglyceride catabolic process (GO:0010896)4.94800127
36regulation of cholesterol esterification (GO:0010872)4.90696289
37homocysteine metabolic process (GO:0050667)4.88318748
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82003999
39reverse cholesterol transport (GO:0043691)4.81623538
40* serine family amino acid catabolic process (GO:0009071)4.78151119
41protein-lipid complex remodeling (GO:0034368)4.75143928
42macromolecular complex remodeling (GO:0034367)4.75143928
43plasma lipoprotein particle remodeling (GO:0034369)4.75143928
44* alpha-amino acid catabolic process (GO:1901606)4.68714055
45lysine metabolic process (GO:0006553)4.64408343
46lysine catabolic process (GO:0006554)4.64408343
47negative regulation of cholesterol transport (GO:0032375)4.62741487
48negative regulation of sterol transport (GO:0032372)4.62741487
49amino-acid betaine metabolic process (GO:0006577)4.62088780
50triglyceride homeostasis (GO:0070328)4.59409257
51acylglycerol homeostasis (GO:0055090)4.59409257
52phospholipid efflux (GO:0033700)4.59084058
53coenzyme catabolic process (GO:0009109)4.50594892
54indolalkylamine metabolic process (GO:0006586)4.45604898
55regulation of plasminogen activation (GO:0010755)4.45580775
56imidazole-containing compound metabolic process (GO:0052803)4.44962409
57glycine metabolic process (GO:0006544)4.37530000
58cellular biogenic amine catabolic process (GO:0042402)4.37507306
59amine catabolic process (GO:0009310)4.37507306
60cellular ketone body metabolic process (GO:0046950)4.34316209
61glutamate metabolic process (GO:0006536)4.31975491
62plasma lipoprotein particle clearance (GO:0034381)4.31217356
63bile acid and bile salt transport (GO:0015721)4.31199882
64* cellular amino acid catabolic process (GO:0009063)4.30060498
65phenylpropanoid metabolic process (GO:0009698)4.27116711
66negative regulation of blood coagulation (GO:0030195)4.23002277
67negative regulation of hemostasis (GO:1900047)4.23002277
68cellular glucuronidation (GO:0052695)4.22888004
69arginine metabolic process (GO:0006525)4.22463278
70cholesterol efflux (GO:0033344)4.21258996
71benzene-containing compound metabolic process (GO:0042537)4.18584619
72opsonization (GO:0008228)4.14076150
73cellular modified amino acid catabolic process (GO:0042219)4.11461124
74ethanol metabolic process (GO:0006067)4.10376816
75alkaloid metabolic process (GO:0009820)4.07807680
76S-adenosylmethionine metabolic process (GO:0046500)4.07363589
77regulation of humoral immune response (GO:0002920)4.07361026
78dicarboxylic acid biosynthetic process (GO:0043650)4.06814881
79drug catabolic process (GO:0042737)4.02243702
80serine family amino acid biosynthetic process (GO:0009070)4.01137766
81aldehyde catabolic process (GO:0046185)4.00039426
82fibrinolysis (GO:0042730)3.98618658
83positive regulation of fatty acid biosynthetic process (GO:0045723)3.97579458
84* serine family amino acid metabolic process (GO:0009069)3.97506250
85ethanol oxidation (GO:0006069)3.96949783
86positive regulation of hemostasis (GO:1900048)3.95992133
87positive regulation of blood coagulation (GO:0030194)3.95992133
88plasma lipoprotein particle assembly (GO:0034377)3.95714535
89low-density lipoprotein particle remodeling (GO:0034374)3.90432415
90negative regulation of coagulation (GO:0050819)3.87915409
91cofactor catabolic process (GO:0051187)3.85781021
92negative regulation of lipase activity (GO:0060192)3.85093909
93blood coagulation, intrinsic pathway (GO:0007597)3.80550248
94complement activation, classical pathway (GO:0006958)3.79035251
95positive regulation of lipoprotein lipase activity (GO:0051006)3.78071610
96positive regulation of triglyceride lipase activity (GO:0061365)3.78071610
97regulation of bile acid biosynthetic process (GO:0070857)3.77717079
98ketone body metabolic process (GO:1902224)3.75801996
99glucuronate metabolic process (GO:0019585)3.74941376
100uronic acid metabolic process (GO:0006063)3.74941376
101positive regulation of lipid catabolic process (GO:0050996)3.74678067
102complement activation (GO:0006956)3.73911437
103* organic acid catabolic process (GO:0016054)3.73412503
104* carboxylic acid catabolic process (GO:0046395)3.73412503
105negative regulation of wound healing (GO:0061045)3.73128433
106positive regulation of coagulation (GO:0050820)3.72715750
107very-low-density lipoprotein particle assembly (GO:0034379)3.72389877
108negative regulation of protein activation cascade (GO:2000258)3.72147492
109protein activation cascade (GO:0072376)3.71477740
110cholesterol homeostasis (GO:0042632)3.71109535
111acetyl-CoA metabolic process (GO:0006084)3.70608540
112cytolysis (GO:0019835)3.68373742
113phospholipid homeostasis (GO:0055091)3.66040069
114NAD biosynthetic process (GO:0009435)3.65301750
115sterol homeostasis (GO:0055092)3.64897763
116regulation of cholesterol homeostasis (GO:2000188)3.62649857
117short-chain fatty acid metabolic process (GO:0046459)3.60789693
118plasma lipoprotein particle organization (GO:0071827)3.59516504
119acute-phase response (GO:0006953)3.59481715
120exogenous drug catabolic process (GO:0042738)3.58988167
121positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.58669484
122disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.54517157
123killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.54517157
124fat-soluble vitamin biosynthetic process (GO:0042362)3.41726155
125acute inflammatory response (GO:0002526)3.40088278
126regulation of lipoprotein particle clearance (GO:0010984)3.35708185
127protein-lipid complex subunit organization (GO:0071825)3.31651039
128heme transport (GO:0015886)3.30294614
129regulation of apoptotic cell clearance (GO:2000425)3.29586864
130flavonoid metabolic process (GO:0009812)3.23497017
131regulation of acute inflammatory response (GO:0002673)3.18915342
132negative regulation of complement activation (GO:0045916)3.17615154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.40880614
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.17949339
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.99937942
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.48254225
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.41923753
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.15126610
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.87459536
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06729209
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04067435
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.65333166
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08714601
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.06883105
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9921858
14BP1_19119308_ChIP-ChIP_Hs578T_Human1.99303947
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99089778
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94096764
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77707999
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.58536975
19CLOCK_20551151_ChIP-Seq_293T_Human1.56517726
20HTT_18923047_ChIP-ChIP_STHdh_Human1.53121483
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48805443
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42811704
23GATA1_22025678_ChIP-Seq_K562_Human1.42030829
24HNF4A_19822575_ChIP-Seq_HepG2_Human1.39278544
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38542178
26VDR_24787735_ChIP-Seq_THP-1_Human1.30398603
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28647452
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21024427
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19332320
30RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18665281
31GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17918132
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14624040
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12217183
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06524553
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03125215
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01995661
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99058825
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98086475
39CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96598002
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94314315
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92819803
42SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89789168
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89429732
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87224702
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87095552
46RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85270478
47AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84781966
48BCL6_27268052_Chip-Seq_Bcells_Human0.84126151
49SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82417946
50IRF8_22096565_ChIP-ChIP_GC-B_Human0.81625980
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80451034
52SPI1_20517297_ChIP-Seq_HL60_Human0.80245231
53ELF1_20517297_ChIP-Seq_JURKAT_Human0.79893011
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79569646
55ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79409098
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78807751
57SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77422093
58RAC3_21632823_ChIP-Seq_H3396_Human0.77367763
59MYC_19829295_ChIP-Seq_ESCs_Human0.77134912
60EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76756224
61GATA4_25053715_ChIP-Seq_YYC3_Human0.76552289
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76267680
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75580821
64BCOR_27268052_Chip-Seq_Bcells_Human0.75543359
65KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74302182
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74064451
67RARA_24833708_ChIP-Seq_LIVER_Mouse0.72991863
68SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72754629
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72225721
70SPI1_23127762_ChIP-Seq_K562_Human0.71433068
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70638581
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.70498402
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.70475697
74BRD4_27068464_Chip-Seq_AML-cells_Mouse0.70259039
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70223256
76SA1_27219007_Chip-Seq_Bcells_Human0.70116503
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70077461
78E2F1_20622854_ChIP-Seq_HELA_Human0.69128674
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.68911383
80ZNF263_19887448_ChIP-Seq_K562_Human0.68118402
81CTCF_20526341_ChIP-Seq_ESCs_Human0.67369180
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66537915
83SOX2_21211035_ChIP-Seq_LN229_Human0.65974882
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65655416
85SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64806162
86ESR2_21235772_ChIP-Seq_MCF-7_Human0.64594379
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64149770
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.64100798
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.63758776
90DNAJC2_21179169_ChIP-ChIP_NT2_Human0.63637041
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.63624904
92BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62826304
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62779787
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62728917
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62728917
96RARB_24833708_ChIP-Seq_LIVER_Mouse0.62680652
97MYB_21317192_ChIP-Seq_ERMYB_Mouse0.62226409
98VDR_24763502_ChIP-Seq_THP-1_Human0.62124754
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61492242
100* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.61272186
101NFE2_27457419_Chip-Seq_LIVER_Mouse0.61133488
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61068172
103GATA3_26560356_Chip-Seq_TH2_Human0.60810011
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.59132859
105HNFA_21074721_ChIP-Seq_CACO-2_Human0.58404507
106GATA6_21074721_ChIP-Seq_CACO-2_Human0.58246751
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.57647018
108CEBPB_22108803_ChIP-Seq_LS180_Human0.57183362
109LXR_22292898_ChIP-Seq_THP-1_Human0.55869852
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53642752
111EGR1_19032775_ChIP-ChIP_M12_Human0.53324596
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51777196
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.51671455
114E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.51080644
115MYC_19915707_ChIP-ChIP_AK7_Human0.50080930
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49474841
117* AR_20517297_ChIP-Seq_VCAP_Human0.48954848
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48366634
119CBP_21632823_ChIP-Seq_H3396_Human0.47867523
120ESET_19884257_ChIP-Seq_ESCs_Mouse0.46358869
121STAT1_17558387_ChIP-Seq_HELA_Human0.44647662
122PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44635124
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.44565421
124* P53_21459846_ChIP-Seq_SAOS-2_Human0.44038401
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43627297
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42866984
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.41969960
128TAF15_26573619_Chip-Seq_HEK293_Human0.41691362
129TAF2_19829295_ChIP-Seq_ESCs_Human0.41494332
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.40452685
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.40218456
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39774104
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.39394236
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.38869081
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.38567385
136GATA1_19941826_ChIP-Seq_K562_Human0.38252282
137GATA2_19941826_ChIP-Seq_K562_Human0.37754913
138BCAT_22108803_ChIP-Seq_LS180_Human0.37614209
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37552328
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37222686
141GATA6_25053715_ChIP-Seq_YYC3_Human0.37021083
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.35577802
143LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35509715
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.35031845
145GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.34758803
146NCOR_22424771_ChIP-Seq_293T_Human0.34399706
147SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34103765
148FOXH1_21741376_ChIP-Seq_EPCs_Human0.34096123
149CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33976637
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.32938852
151FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.32887477
152SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.32835253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.25970246
2MP0005360_urolithiasis7.59233592
3MP0005085_abnormal_gallbladder_physiolo6.47660143
4MP0005365_abnormal_bile_salt6.17179992
5MP0008875_abnormal_xenobiotic_pharmacok5.20514130
6MP0003806_abnormal_nucleotide_metabolis4.22076294
7MP0003252_abnormal_bile_duct3.89967841
8MP0010329_abnormal_lipoprotein_level3.56476047
9MP0009840_abnormal_foam_cell3.36878067
10MP0005083_abnormal_biliary_tract2.94872717
11MP0003195_calcinosis2.86514639
12MP0005332_abnormal_amino_acid2.84388792
13MP0005058_abnormal_lysosome_morphology2.59816336
14MP0001666_abnormal_nutrient_absorption2.58567014
15MP0003191_abnormal_cellular_cholesterol2.37961146
16MP0000609_abnormal_liver_physiology2.15580073
17MP0004019_abnormal_vitamin_homeostasis2.10911428
18MP0002118_abnormal_lipid_homeostasis2.10131647
19MP0002138_abnormal_hepatobiliary_system1.99405872
20MP0003868_abnormal_feces_composition1.93611021
21MP0005319_abnormal_enzyme/_coenzyme1.83574306
22MP0001764_abnormal_homeostasis1.70726958
23MP0003172_abnormal_lysosome_physiology1.62028694
24MP0003303_peritoneal_inflammation1.61926528
25MP0009697_abnormal_copulation1.58850906
26MP0009785_altered_susceptibility_to1.57485105
27MP0005584_abnormal_enzyme/coenzyme_acti1.56992028
28MP0005451_abnormal_body_composition1.48574765
29MP0002148_abnormal_hypersensitivity_rea1.36232038
30MP0003011_delayed_dark_adaptation1.34799764
31MP0003186_abnormal_redox_activity1.27122250
32MP0003656_abnormal_erythrocyte_physiolo1.25032348
33MP0009643_abnormal_urine_homeostasis1.23633162
34MP0002419_abnormal_innate_immunity1.19424253
35MP0000598_abnormal_liver_morphology1.17968410
36MP0003705_abnormal_hypodermis_morpholog1.17270332
37MP0005647_abnormal_sex_gland1.13399550
38MP0004510_myositis1.09219989
39MP0000604_amyloidosis1.08099528
40MP0009764_decreased_sensitivity_to1.06561528
41MP0002254_reproductive_system_inflammat1.03256534
42MP0000343_altered_response_to1.02689795
43MP0009763_increased_sensitivity_to1.02263597
44MP0005025_abnormal_response_to1.00759350
45MP0005670_abnormal_white_adipose0.99716075
46MP0003879_abnormal_hair_cell0.99087183
47MP0005167_abnormal_blood-brain_barrier0.95465306
48MP0010368_abnormal_lymphatic_system0.92807071
49MP0001790_abnormal_immune_system0.90547477
50MP0005387_immune_system_phenotype0.90547477
51MP0005636_abnormal_mineral_homeostasis0.90212688
52MP0001835_abnormal_antigen_presentation0.89320276
53MP0008469_abnormal_protein_level0.89165628
54MP0009642_abnormal_blood_homeostasis0.87053466
55MP0000685_abnormal_immune_system0.83608186
56MP0005408_hypopigmentation0.83097671
57MP0006036_abnormal_mitochondrial_physio0.82051162
58MP0005000_abnormal_immune_tolerance0.81369894
59MP0005376_homeostasis/metabolism_phenot0.81042856
60MP0009765_abnormal_xenobiotic_induced0.78417910
61MP0002876_abnormal_thyroid_physiology0.78229294
62MP0002078_abnormal_glucose_homeostasis0.76677612
63MP0005671_abnormal_response_to0.74137326
64MP0005397_hematopoietic_system_phenotyp0.74043617
65MP0001545_abnormal_hematopoietic_system0.74043617
66MP0002971_abnormal_brown_adipose0.73802970
67MP0001533_abnormal_skeleton_physiology0.71698403
68MP0005084_abnormal_gallbladder_morpholo0.71203577
69MP0005220_abnormal_exocrine_pancreas0.70393734
70MP0003690_abnormal_glial_cell0.70034838
71MP0004130_abnormal_muscle_cell0.69331798
72MP0005334_abnormal_fat_pad0.69229821
73MP0002332_abnormal_exercise_endurance0.68991845
74MP0005535_abnormal_body_temperature0.66472330
75MP0005266_abnormal_metabolism0.66451993
76MP0003329_amyloid_beta_deposits0.65853733
77MP0009053_abnormal_anal_canal0.64352748
78MP0000920_abnormal_myelination0.63243279
79MP0001661_extended_life_span0.62779464
80MP0002723_abnormal_immune_serum0.62745241
81MP0001800_abnormal_humoral_immune0.61752815
82MP0010386_abnormal_urinary_bladder0.61177697
83MP0002998_abnormal_bone_remodeling0.60289215
84MP0002452_abnormal_antigen_presenting0.59792052
85MP0010155_abnormal_intestine_physiology0.59716443
86MP0000639_abnormal_adrenal_gland0.59099166
87MP0001756_abnormal_urination0.58415985
88MP0001915_intracranial_hemorrhage0.55669777
89MP0006035_abnormal_mitochondrial_morpho0.55553584
90MP0005448_abnormal_energy_balance0.53608953
91MP0005464_abnormal_platelet_physiology0.52396542
92MP0002822_catalepsy0.50156836
93MP0005395_other_phenotype0.48413357
94MP0008874_decreased_physiological_sensi0.48136083
95MP0003633_abnormal_nervous_system0.47709129
96MP0003638_abnormal_response/metabolism_0.47289555
97MP0002405_respiratory_system_inflammati0.46821776
98MP0003718_maternal_effect0.46215819
99MP0008873_increased_physiological_sensi0.45877481
100MP0002136_abnormal_kidney_physiology0.44517854
101MP0003436_decreased_susceptibility_to0.42680097
102MP0005666_abnormal_adipose_tissue0.42509923
103MP0002928_abnormal_bile_duct0.42405618
104MP0003075_altered_response_to0.41584024
105MP0002837_dystrophic_cardiac_calcinosis0.41487099
106MP0003724_increased_susceptibility_to0.41252286
107MP0004782_abnormal_surfactant_physiolog0.41085286
108MP0008872_abnormal_physiological_respon0.39331578
109MP0005248_abnormal_Harderian_gland0.39312646
110MP0003953_abnormal_hormone_level0.39246353
111MP0005166_decreased_susceptibility_to0.39156682
112MP0000579_abnormal_nail_morphology0.37181286
113MP0009672_abnormal_birth_weight0.35525524
114MP0004381_abnormal_hair_follicle0.34816957
115MP0009115_abnormal_fat_cell0.33464751
116MP0009384_cardiac_valve_regurgitation0.32400367
117MP0001243_abnormal_dermal_layer0.31763485
118MP0002970_abnormal_white_adipose0.31657204
119MP0000249_abnormal_blood_vessel0.31490322
120MP0000230_abnormal_systemic_arterial0.31054650
121MP0002168_other_aberrant_phenotype0.30604949
122MP0001853_heart_inflammation0.30565634
123MP0004883_abnormal_blood_vessel0.30271067
124MP0002796_impaired_skin_barrier0.30251791
125MP0001881_abnormal_mammary_gland0.28874878
126MP0006082_CNS_inflammation0.28669817
127MP0001845_abnormal_inflammatory_respons0.27629134
128MP0002090_abnormal_vision0.26432256
129MP0002060_abnormal_skin_morphology0.24963974
130MP0005164_abnormal_response_to0.23847383
131MP0002132_abnormal_respiratory_system0.23702271

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.69159939
2Deep venous thrombosis (HP:0002625)7.38606142
3Intrahepatic cholestasis (HP:0001406)7.15431961
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.99674527
5Prolonged partial thromboplastin time (HP:0003645)6.54270334
6Hypobetalipoproteinemia (HP:0003563)6.42237996
7Xanthomatosis (HP:0000991)6.28281601
8Hyperlipoproteinemia (HP:0010980)5.72421666
9Complement deficiency (HP:0004431)5.39982261
10Hypolipoproteinemia (HP:0010981)4.79088619
11Joint hemorrhage (HP:0005261)4.74701540
12Hyperammonemia (HP:0001987)4.68146041
13Epidermoid cyst (HP:0200040)4.53778514
14Abnormality of glycolipid metabolism (HP:0010969)4.51779674
15Abnormality of liposaccharide metabolism (HP:0010968)4.51779674
16Abnormality of glycosphingolipid metabolism (HP:0004343)4.51779674
17Abnormality of methionine metabolism (HP:0010901)4.49956585
18Abnormality of the common coagulation pathway (HP:0010990)4.41836831
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39295942
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.39205437
21Hyperglycinemia (HP:0002154)4.36030352
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.30663083
23Ketosis (HP:0001946)4.29426452
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.28570342
25Hypoalphalipoproteinemia (HP:0003233)4.23249734
26Abnormality of pyrimidine metabolism (HP:0004353)4.10052438
27Fat malabsorption (HP:0002630)4.01963859
28Abnormality of complement system (HP:0005339)3.94065027
29Hyperglycinuria (HP:0003108)3.89990833
30Abnormality of glycine metabolism (HP:0010895)3.87407456
31Abnormality of serine family amino acid metabolism (HP:0010894)3.87407456
32Hypoglycemic coma (HP:0001325)3.78113205
33Abnormality of the intrinsic pathway (HP:0010989)3.74703128
34Hypercholesterolemia (HP:0003124)3.62517378
35Conjugated hyperbilirubinemia (HP:0002908)3.59287767
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37952726
37Abnormality of fatty-acid metabolism (HP:0004359)3.31942212
38Hyperbilirubinemia (HP:0002904)3.28048897
39Purpura (HP:0000979)3.23157788
40Abnormality of nucleobase metabolism (HP:0010932)3.15241595
41Abnormality of serum amino acid levels (HP:0003112)3.13532367
42Increased cerebral lipofuscin (HP:0011813)3.10380084
43Spontaneous abortion (HP:0005268)3.09922275
44Steatorrhea (HP:0002570)3.07189032
45Vacuolated lymphocytes (HP:0001922)3.05489082
46Delayed CNS myelination (HP:0002188)3.04271141
47Ketoacidosis (HP:0001993)2.98089137
48Myocardial infarction (HP:0001658)2.97714493
49Hepatocellular carcinoma (HP:0001402)2.94206973
50Hypochromic microcytic anemia (HP:0004840)2.85300882
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.80536291
52Abnormality of polysaccharide metabolism (HP:0011012)2.80536291
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.80536291
54Skin nodule (HP:0200036)2.79839379
55Dysostosis multiplex (HP:0000943)2.76880417
56Metabolic acidosis (HP:0001942)2.76177284
57Systemic lupus erythematosus (HP:0002725)2.75870966
58Mucopolysacchariduria (HP:0008155)2.71259317
59Urinary glycosaminoglycan excretion (HP:0003541)2.71259317
60Abnormality of purine metabolism (HP:0004352)2.67836174
61Lethargy (HP:0001254)2.64205956
62Increased serum ferritin (HP:0003281)2.61017067
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.58734412
64Pulmonary embolism (HP:0002204)2.57361098
65Vascular calcification (HP:0004934)2.56999253
66Dicarboxylic aciduria (HP:0003215)2.53107706
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53107706
68Spastic diplegia (HP:0001264)2.52171641
69Cerebral edema (HP:0002181)2.51682582
70Mitral stenosis (HP:0001718)2.49036404
71Gout (HP:0001997)2.46359807
72Abnormal gallbladder morphology (HP:0012437)2.43697399
73Neonatal onset (HP:0003623)2.42920291
74Irritability (HP:0000737)2.42164328
75Retinal atrophy (HP:0001105)2.41213731
76Hypoglycemic seizures (HP:0002173)2.40495941
77Glomerulonephritis (HP:0000099)2.40353759
78Fair hair (HP:0002286)2.38398071
79Cholelithiasis (HP:0001081)2.38048846
80Acanthocytosis (HP:0001927)2.37224847
81Amyloidosis (HP:0011034)2.36816109
82Recurrent gram-negative bacterial infections (HP:0005420)2.36637865
83Abnormal gallbladder physiology (HP:0012438)2.32261011
84Cholecystitis (HP:0001082)2.32261011
85Cardiovascular calcification (HP:0011915)2.27847242
86Loss of speech (HP:0002371)2.24266447
87Gingival bleeding (HP:0000225)2.22779413
88Malnutrition (HP:0004395)2.20027366
89Gangrene (HP:0100758)2.19811859
90Disinhibition (HP:0000734)2.15593671
91Brushfield spots (HP:0001088)2.14589703
92Late onset (HP:0003584)2.14335027
93Esophageal varix (HP:0002040)2.12537585
94Pancreatitis (HP:0001733)2.12328151
95Enlarged kidneys (HP:0000105)2.11665822
96Sensorimotor neuropathy (HP:0007141)2.11241835
97Menorrhagia (HP:0000132)2.11206613
98Thrombophlebitis (HP:0004418)2.10027993
99Neurofibrillary tangles (HP:0002185)2.09415786
100Vomiting (HP:0002013)2.08762155
101Opisthotonus (HP:0002179)2.04317873
102Abnormality of the gallbladder (HP:0005264)1.98536751
103Optic neuritis (HP:0100653)1.98519430
104Retrobulbar optic neuritis (HP:0100654)1.98519430
105Generalized aminoaciduria (HP:0002909)1.98186490
106Hemorrhage of the eye (HP:0011885)1.96773367
107Elevated alkaline phosphatase (HP:0003155)1.95664558
108Orchitis (HP:0100796)1.95553192
109Hyperinsulinemic hypoglycemia (HP:0000825)1.95263427
110Neonatal hypoglycemia (HP:0001998)1.95005764
111Mutism (HP:0002300)1.94527368
112Poikilocytosis (HP:0004447)1.94323320
113Abnormality of iron homeostasis (HP:0011031)1.93856307
114Alkalosis (HP:0001948)1.91779268
115Rickets (HP:0002748)1.89466854
116Reduced antithrombin III activity (HP:0001976)1.89286216
117Abnormality of transition element cation homeostasis (HP:0011030)1.89006605
118Mesangial abnormality (HP:0001966)1.88676838
119Abnormal cartilage morphology (HP:0002763)1.87584658
120Status epilepticus (HP:0002133)1.86824545
121Hydroxyprolinuria (HP:0003080)1.86791472
122Abnormality of proline metabolism (HP:0010907)1.86791472
123Hypophosphatemic rickets (HP:0004912)1.86531358
124Pathologic fracture (HP:0002756)1.81737915
125Renal cortical cysts (HP:0000803)1.80057136
126Elevated hepatic transaminases (HP:0002910)1.79662384
127Abnormality of the Achilles tendon (HP:0005109)1.79646253
128Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79247135
129Joint swelling (HP:0001386)1.79118188
130Hyperglycemia (HP:0003074)1.78761648
131Abnormality of alkaline phosphatase activity (HP:0004379)1.76476050
132Abnormal enzyme/coenzyme activity (HP:0012379)1.75730190
133Epistaxis (HP:0000421)1.75243770
134Generalized hypopigmentation of hair (HP:0011358)1.74704957
135Axonal loss (HP:0003447)1.74054348
136Nephritis (HP:0000123)1.71205320
137Abnormality of vitamin metabolism (HP:0100508)1.70652891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.24128875
2FGFR44.65161650
3ERN14.60057617
4SIK14.52443598
5GRK73.18813632
6ERBB43.04043506
7TAOK32.95290921
8INSRR2.93181380
9BLK2.90548430
10NME22.77722123
11ADRBK22.63929298
12MAP2K42.39850155
13ACVR1B2.23001812
14CAMKK22.20117885
15PKN22.19774574
16MST1R1.98174646
17IKBKB1.95224317
18MAPK111.91430226
19FLT31.83206199
20TRIB31.79968978
21MATK1.76555244
22PDK21.70549147
23TYK21.65683238
24PIK3CG1.65383527
25LATS11.58819396
26DDR21.57938895
27ABL21.53745297
28PTK61.51907183
29TXK1.50434242
30DAPK21.48469029
31PIM21.43939588
32FGFR21.36548537
33NEK91.33465791
34FRK1.28660185
35JAK21.24143174
36MAP4K11.24021645
37KDR1.21852178
38MAP3K71.19354967
39CHUK1.17294981
40PINK11.15952863
41GRK61.14132039
42FGR1.14032245
43TBK11.13224520
44TNK21.12263263
45PRKAA21.12052022
46MAP2K31.05929309
47ERBB21.05877562
48TAOK11.02731773
49JAK11.00804901
50MAP3K141.00727900
51IRAK41.00528699
52MAPK41.00402576
53ZAP700.98357437
54MAP3K100.94358145
55CDC42BPA0.94196995
56LYN0.92562223
57PRKCZ0.92279710
58EPHB10.89803162
59MOS0.89212895
60SYK0.88213991
61KIT0.87942263
62MAPK150.87897117
63MAPK120.86200248
64EPHA30.84717195
65CDK60.81379223
66MAP3K30.80388645
67STK38L0.80165901
68MAP3K110.79745734
69CAMK2G0.79075160
70MET0.77946192
71DYRK1B0.77537830
72CAMKK10.77255206
73JAK30.76893655
74PRKACG0.76524187
75MAP2K60.74047348
76CSK0.72051898
77TIE10.71342514
78GSK3A0.66188037
79LCK0.65923016
80SGK30.64476449
81PRKAA10.62713670
82FES0.60824945
83MAPK70.60678181
84CAMK1D0.60639763
85IKBKE0.59630343
86PRPF4B0.59217507
87EPHA40.58552930
88FGFR30.58439679
89IRAK30.57902129
90RIPK10.56953357
91TAOK20.56527248
92NTRK30.55117477
93PDPK10.54559653
94PTK20.54326956
95TGFBR20.54270437
96CSF1R0.51699121
97ARAF0.51606727
98MAP3K130.51262104
99CSNK1G10.51163043
100PRKCQ0.50867125
101TGFBR10.50842356
102MARK30.49696587
103PRKACA0.49111785
104PRKG10.48603068
105PKN10.48175204
106MAP3K50.47411324
107WNK30.46385108
108SGK20.45322985
109FER0.45241015
110RIPK40.45065726
111IGF1R0.43760503
112MAP2K10.43507539
113PRKCG0.41780144
114RET0.41746768
115BMPR20.41510486
116MAP4K20.40971135
117GRK10.40104965
118CDK40.39961451
119ICK0.38613790
120MAP3K60.38091623
121RPS6KA60.37496541
122CAMK40.36035945
123EGFR0.35632906
124MTOR0.34179758
125RPS6KL10.33676722
126RPS6KC10.33676722
127CSNK1G20.33586512
128PDK10.32825440
129HCK0.31638445
130RPS6KA20.30836905
131IRAK10.30372152
132SGK4940.30305174
133SGK2230.30305174
134CSNK1G30.30175271
135MAP3K10.28723447
136LATS20.27964015
137IRAK20.27550771
138PRKCA0.26135530
139PIK3CA0.24624122
140PBK0.23214158
141ABL10.21609889
142CSNK1A1L0.20678420
143PDK30.19785876
144PDK40.19785876
145PAK30.19630729

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55509164
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.65088694
3Nitrogen metabolism_Homo sapiens_hsa009103.56087499
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32495288
5Arginine biosynthesis_Homo sapiens_hsa002203.25306432
6Complement and coagulation cascades_Homo sapiens_hsa046102.75933627
7Tryptophan metabolism_Homo sapiens_hsa003802.71171155
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63183060
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58603699
10* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46743989
11Fatty acid degradation_Homo sapiens_hsa000712.43630032
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35479385
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24111172
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14231938
15Butanoate metabolism_Homo sapiens_hsa006502.09011527
16Peroxisome_Homo sapiens_hsa041462.06661608
17Chemical carcinogenesis_Homo sapiens_hsa052041.95072376
18Histidine metabolism_Homo sapiens_hsa003401.92874058
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.92415898
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92198644
21Propanoate metabolism_Homo sapiens_hsa006401.88530234
22PPAR signaling pathway_Homo sapiens_hsa033201.85420683
23Caffeine metabolism_Homo sapiens_hsa002321.82760824
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.82583637
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.77905305
26Fatty acid metabolism_Homo sapiens_hsa012121.74454070
27Staphylococcus aureus infection_Homo sapiens_hsa051501.73838547
28beta-Alanine metabolism_Homo sapiens_hsa004101.68702129
29Retinol metabolism_Homo sapiens_hsa008301.66724985
30Phenylalanine metabolism_Homo sapiens_hsa003601.64674417
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64090953
32Selenocompound metabolism_Homo sapiens_hsa004501.58793744
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57521070
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57254668
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52706315
36Other glycan degradation_Homo sapiens_hsa005111.47647050
37Bile secretion_Homo sapiens_hsa049761.47160957
38Tyrosine metabolism_Homo sapiens_hsa003501.46259363
39Pyruvate metabolism_Homo sapiens_hsa006201.35485733
40Sulfur metabolism_Homo sapiens_hsa009201.34257376
41* Cysteine and methionine metabolism_Homo sapiens_hsa002701.28256069
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26842961
43Fatty acid elongation_Homo sapiens_hsa000621.26121782
44Folate biosynthesis_Homo sapiens_hsa007901.25044626
45* Biosynthesis of amino acids_Homo sapiens_hsa012301.19410527
46ABC transporters_Homo sapiens_hsa020101.16982576
47Steroid biosynthesis_Homo sapiens_hsa001001.14447591
48Fat digestion and absorption_Homo sapiens_hsa049751.13320146
49Lysosome_Homo sapiens_hsa041421.10090265
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07516775
51* Carbon metabolism_Homo sapiens_hsa012001.06014154
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.99958753
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.99021778
54Pertussis_Homo sapiens_hsa051330.98588783
55Arginine and proline metabolism_Homo sapiens_hsa003300.98494722
56Sulfur relay system_Homo sapiens_hsa041220.98121859
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95047242
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89991449
59Vitamin B6 metabolism_Homo sapiens_hsa007500.87993332
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87093331
61Vitamin digestion and absorption_Homo sapiens_hsa049770.81301783
62Lysine degradation_Homo sapiens_hsa003100.80015566
63One carbon pool by folate_Homo sapiens_hsa006700.74195001
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69440023
65Glycerolipid metabolism_Homo sapiens_hsa005610.65961155
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65872261
67Glutathione metabolism_Homo sapiens_hsa004800.64772343
68Pentose phosphate pathway_Homo sapiens_hsa000300.55551215
69Rheumatoid arthritis_Homo sapiens_hsa053230.49495057
70Fatty acid biosynthesis_Homo sapiens_hsa000610.48482097
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47696262
72Asthma_Homo sapiens_hsa053100.47660524
73* Metabolic pathways_Homo sapiens_hsa011000.45543862
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41198333
75Prion diseases_Homo sapiens_hsa050200.38596258
76Allograft rejection_Homo sapiens_hsa053300.34397440
77Osteoclast differentiation_Homo sapiens_hsa043800.29824213
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.26203417
79Phagosome_Homo sapiens_hsa041450.25630155
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25222523
81Fructose and mannose metabolism_Homo sapiens_hsa000510.24979179
82Sphingolipid metabolism_Homo sapiens_hsa006000.24165947
83Mineral absorption_Homo sapiens_hsa049780.24076763
84Galactose metabolism_Homo sapiens_hsa000520.23496901
85Collecting duct acid secretion_Homo sapiens_hsa049660.23098051
86Insulin resistance_Homo sapiens_hsa049310.23038732
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22846209
88Leishmaniasis_Homo sapiens_hsa051400.22811141
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.21559048
90Linoleic acid metabolism_Homo sapiens_hsa005910.20960113
91Tuberculosis_Homo sapiens_hsa051520.20887252
92Autoimmune thyroid disease_Homo sapiens_hsa053200.20711139
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17319292
94Graft-versus-host disease_Homo sapiens_hsa053320.17288202
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.17018315
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.16282895
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15222651
98Malaria_Homo sapiens_hsa051440.12175010
99Glucagon signaling pathway_Homo sapiens_hsa049220.11073156
100Type I diabetes mellitus_Homo sapiens_hsa049400.09908999
101Antigen processing and presentation_Homo sapiens_hsa046120.07365353
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.03900930
103AMPK signaling pathway_Homo sapiens_hsa041520.02638956
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2533621
105Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2413538
106Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2379183
107Amoebiasis_Homo sapiens_hsa05146-0.2284163
108Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2208074
109Renin-angiotensin system_Homo sapiens_hsa04614-0.2055584
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2043271
111Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1950781
112Hepatitis C_Homo sapiens_hsa05160-0.1836469
113Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1774259
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1584484
115Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1550193
116Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1506394
117Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1496842
118African trypanosomiasis_Homo sapiens_hsa05143-0.1353967
119Regulation of autophagy_Homo sapiens_hsa04140-0.1313266
120Insulin signaling pathway_Homo sapiens_hsa04910-0.0992459
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0879481
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0812461
123Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0684653
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0418198

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