SEBOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)7.37781421
2regulation of meiosis (GO:0040020)6.95545534
3protein K6-linked ubiquitination (GO:0085020)6.34983434
4piRNA metabolic process (GO:0034587)6.10904046
5negative regulation of hormone biosynthetic process (GO:0032353)6.00161943
6negative regulation of hormone metabolic process (GO:0032351)6.00161943
7regulation of exit from mitosis (GO:0007096)5.94523929
8regulation of histone H3-K27 methylation (GO:0061085)5.87744771
9DNA damage response, signal transduction resulting in transcription (GO:0042772)5.79168460
10mitotic metaphase plate congression (GO:0007080)5.78561839
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.78024661
12regulation of meiotic cell cycle (GO:0051445)5.47609533
13DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla5.43187595
14positive regulation of megakaryocyte differentiation (GO:0045654)5.34037658
15monoubiquitinated protein deubiquitination (GO:0035520)5.33289994
16female gamete generation (GO:0007292)5.18949290
17male meiosis (GO:0007140)5.04589713
18negative regulation of meiosis (GO:0045835)5.03393377
19mitotic chromosome condensation (GO:0007076)4.97455802
20negative regulation of smooth muscle cell differentiation (GO:0051151)4.96118958
21DNA damage induced protein phosphorylation (GO:0006975)4.95427903
22regulation of female gonad development (GO:2000194)4.94425243
23histone H2A monoubiquitination (GO:0035518)4.90184640
24meiotic chromosome segregation (GO:0045132)4.76880203
25negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.67728962
26regulation of RIG-I signaling pathway (GO:0039535)4.67723145
27glycerophospholipid catabolic process (GO:0046475)4.55506105
28regulation of glucocorticoid metabolic process (GO:0031943)4.54752995
29metaphase plate congression (GO:0051310)4.53756935
30oocyte maturation (GO:0001556)4.52728839
31type B pancreatic cell development (GO:0003323)4.45180837
32myoblast migration (GO:0051451)4.43901318
33regulation of sister chromatid cohesion (GO:0007063)4.41237231
34maturation of 5.8S rRNA (GO:0000460)4.38107157
35positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.33761136
36establishment of chromosome localization (GO:0051303)4.31143222
37microtubule nucleation (GO:0007020)4.17402640
38positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.16974350
39histone H2A ubiquitination (GO:0033522)4.15235101
40regulation of cell maturation (GO:1903429)4.09560110
41negative regulation of cell aging (GO:0090344)4.00445943
42regulation of transforming growth factor beta2 production (GO:0032909)3.97811891
43mitotic sister chromatid segregation (GO:0000070)3.97636889
44mitotic sister chromatid cohesion (GO:0007064)3.96959766
45regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.85676153
46regulation of steroid hormone biosynthetic process (GO:0090030)3.76066028
47attachment of spindle microtubules to kinetochore (GO:0008608)3.74327052
48protein complex localization (GO:0031503)3.73483667
49meiotic cell cycle (GO:0051321)3.71703880
50fat-soluble vitamin biosynthetic process (GO:0042362)3.70048278
51positive regulation of granulocyte differentiation (GO:0030854)3.64483234
52negative regulation of alcohol biosynthetic process (GO:1902931)3.64124302
53male meiosis I (GO:0007141)3.61406252
54female gonad development (GO:0008585)3.56915050
55meiosis I (GO:0007127)3.55222317
56regulation of retinoic acid receptor signaling pathway (GO:0048385)3.51005006
57microtubule severing (GO:0051013)3.50951778
58gene silencing by RNA (GO:0031047)3.50358205
59protein K11-linked ubiquitination (GO:0070979)3.49967354
60positive regulation of DNA-dependent DNA replication (GO:2000105)3.46901314
61regulation of integrin-mediated signaling pathway (GO:2001044)3.43852676
62negative regulation of keratinocyte proliferation (GO:0010839)3.42792682
63sister chromatid cohesion (GO:0007062)3.42409557
64chromosome segregation (GO:0007059)3.40311962
65phosphatidylglycerol biosynthetic process (GO:0006655)3.28451938
66cytoplasmic mRNA processing body assembly (GO:0033962)3.23847882
67DNA methylation involved in gamete generation (GO:0043046)3.19433229
68regulation of clathrin-mediated endocytosis (GO:2000369)3.17766827
69meiotic nuclear division (GO:0007126)3.16481161
70notochord development (GO:0030903)3.16437251
71regulation of mononuclear cell migration (GO:0071675)3.15602986
72regulation of chromosome segregation (GO:0051983)3.14794749
73positive regulation of sodium ion transmembrane transport (GO:1902307)3.14784521
74synaptonemal complex assembly (GO:0007130)3.14622448
75sister chromatid segregation (GO:0000819)3.13980920
76negative regulation of reproductive process (GO:2000242)3.09624532
77negative regulation of meiotic cell cycle (GO:0051447)3.07821184
78regulation of proton transport (GO:0010155)3.04690091
79glandular epithelial cell development (GO:0002068)3.04281106
80positive regulation of meiosis (GO:0045836)3.03157796
81regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.99548025
82regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.99548025
83snRNA transcription (GO:0009301)2.99522787
84regulation of telomere maintenance via telomerase (GO:0032210)2.99480905
85positive regulation of protein targeting to membrane (GO:0090314)2.97367784
86protein localization to chromosome (GO:0034502)2.96071561
87cellular protein catabolic process (GO:0044257)2.95925654
88chaperone-mediated protein transport (GO:0072321)2.93963528
89sphingosine metabolic process (GO:0006670)2.92864708
90spindle checkpoint (GO:0031577)2.92576052
91meiotic cell cycle process (GO:1903046)2.91872652
92parturition (GO:0007567)2.90750714
93regulation of spindle organization (GO:0090224)2.90623809
94chromatin remodeling at centromere (GO:0031055)2.90426690
95regulation of early endosome to late endosome transport (GO:2000641)2.90326190
96positive regulation of meiotic cell cycle (GO:0051446)2.89999673
97negative regulation of steroid biosynthetic process (GO:0010894)2.87882267
98nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.86990101
99negative regulation of histone methylation (GO:0031061)2.84299279
100ovulation cycle (GO:0042698)2.84256265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.07832949
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.90686596
3KAP1_22055183_ChIP-Seq_ESCs_Mouse3.51975975
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17158464
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17020977
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.96445808
7GATA1_26923725_Chip-Seq_HPCs_Mouse2.80171467
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79837898
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.76455425
10AR_21909140_ChIP-Seq_LNCAP_Human2.56037648
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39731981
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.34875383
13E2F7_22180533_ChIP-Seq_HELA_Human2.34761324
14LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24418484
15IGF1R_20145208_ChIP-Seq_DFB_Human2.07836647
16MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.04472471
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.98361057
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87936605
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87075943
20RUNX1_26923725_Chip-Seq_HPCs_Mouse1.85793250
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85311403
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.66885075
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64102297
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.60840719
25TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.60394977
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57623329
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55066646
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55066646
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54436636
30CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51718453
31STAT3_23295773_ChIP-Seq_U87_Human1.50343675
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.49339091
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.49262605
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43629822
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.39687905
36MYC_18940864_ChIP-ChIP_HL60_Human1.38276258
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.37978951
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36522953
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32951852
40STAT1_17558387_ChIP-Seq_HELA_Human1.31329040
41FUS_26573619_Chip-Seq_HEK293_Human1.31161558
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30221848
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28573263
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.27268773
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.25082369
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24849875
47CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21633119
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.21286338
49SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18209940
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14954616
51CDX2_22108803_ChIP-Seq_LS180_Human1.14819677
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13242744
53RNF2_27304074_Chip-Seq_NSC_Mouse1.13064906
54TBL1_22424771_ChIP-Seq_293T_Human1.12827934
55SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12252040
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12072794
57NFYA_21822215_ChIP-Seq_K562_Human1.10591350
58CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09762669
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08662648
60ERG_20517297_ChIP-Seq_VCAP_Human1.08089638
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07438814
62TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04606971
63LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02822757
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02156322
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01930746
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00495332
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99336710
68AR_21572438_ChIP-Seq_LNCaP_Human0.99174505
69NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98621850
70PRDM14_20953172_ChIP-Seq_ESCs_Human0.97068478
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96635250
72GATA3_21867929_ChIP-Seq_TH1_Mouse0.95568342
73SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94154735
74FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94092702
75KAP1_27257070_Chip-Seq_ESCs_Mouse0.93931841
76ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93874319
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93710377
78KDM2B_26808549_Chip-Seq_REH_Human0.90812992
79OCT1_27270436_Chip-Seq_PROSTATE_Human0.89501084
80PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88943017
81PIAS1_25552417_ChIP-Seq_VCAP_Human0.87501470
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.86554349
83HNFA_21074721_ChIP-Seq_CACO-2_Human0.86408628
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85685751
85AR_25329375_ChIP-Seq_VCAP_Human0.85356968
86GBX2_23144817_ChIP-Seq_PC3_Human0.85342467
87SMAD4_21799915_ChIP-Seq_A2780_Human0.84057868
88WDR5_24793694_ChIP-Seq_LNCAP_Human0.83827333
89FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82631375
90KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81940428
91STAT3_18555785_ChIP-Seq_MESCs_Mouse0.81450916
92FOXO3_23340844_ChIP-Seq_DLD1_Human0.81025633
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.80614048
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.80532844
95GF1B_26923725_Chip-Seq_HPCs_Mouse0.80253555
96SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.79070985
97ISL1_27105846_Chip-Seq_CPCs_Mouse0.79051324
98PHF8_20622853_ChIP-Seq_HELA_Human0.78210600
99TCF4_23295773_ChIP-Seq_U87_Human0.78098220
100* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77481800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue7.06401001
2MP0002653_abnormal_ependyma_morphology5.87750772
3MP0005451_abnormal_body_composition5.06633039
4MP0002102_abnormal_ear_morphology4.73402020
5MP0003718_maternal_effect4.10557571
6MP0003693_abnormal_embryo_hatching3.46968323
7MP0006292_abnormal_olfactory_placode2.70390432
8MP0003123_paternal_imprinting2.68541344
9MP0004185_abnormal_adipocyte_glucose2.68240024
10MP0008877_abnormal_DNA_methylation2.56675136
11MP0003111_abnormal_nucleus_morphology2.48966217
12MP0003077_abnormal_cell_cycle2.25085068
13MP0003699_abnormal_female_reproductive2.19369890
14MP0001119_abnormal_female_reproductive2.18715210
15MP0004957_abnormal_blastocyst_morpholog2.18368839
16MP0002249_abnormal_larynx_morphology2.05193741
17MP0005395_other_phenotype2.03809466
18MP0005408_hypopigmentation1.94919737
19MP0010094_abnormal_chromosome_stability1.94858022
20MP0001929_abnormal_gametogenesis1.89666849
21MP0001529_abnormal_vocalization1.89152972
22MP0010368_abnormal_lymphatic_system1.86448791
23MP0005646_abnormal_pituitary_gland1.82239817
24MP0000653_abnormal_sex_gland1.77615590
25MP0000579_abnormal_nail_morphology1.72052641
26MP0010234_abnormal_vibrissa_follicle1.68122386
27MP0005310_abnormal_salivary_gland1.68082148
28MP0001346_abnormal_lacrimal_gland1.62889192
29MP0003937_abnormal_limbs/digits/tail_de1.62836619
30MP0002210_abnormal_sex_determination1.61703462
31MP0001915_intracranial_hemorrhage1.57319132
32MP0000639_abnormal_adrenal_gland1.40177190
33MP0001851_eye_inflammation1.32305673
34MP0001145_abnormal_male_reproductive1.27337144
35MP0000462_abnormal_digestive_system1.26306643
36MP0010386_abnormal_urinary_bladder1.24213286
37MP0003787_abnormal_imprinting1.19121500
38MP0002085_abnormal_embryonic_tissue1.18905856
39MP0002161_abnormal_fertility/fecundity1.15581786
40MP0002139_abnormal_hepatobiliary_system1.12184750
41MP0002163_abnormal_gland_morphology1.12037272
42MP0001905_abnormal_dopamine_level1.08780269
43MP0001697_abnormal_embryo_size1.06563492
44MP0003121_genomic_imprinting1.06310411
45MP0001502_abnormal_circadian_rhythm1.05059354
46MP0001730_embryonic_growth_arrest1.01056241
47MP0005257_abnormal_intraocular_pressure0.97119699
48MP0002084_abnormal_developmental_patter0.96925148
49MP0005551_abnormal_eye_electrophysiolog0.95973952
50MP0004270_analgesia0.94130803
51MP0005187_abnormal_penis_morphology0.93360666
52MP0002877_abnormal_melanocyte_morpholog0.92500307
53MP0000566_synostosis0.92094939
54MP0000350_abnormal_cell_proliferation0.91938922
55MP0000613_abnormal_salivary_gland0.91615550
56MP0008932_abnormal_embryonic_tissue0.88998624
57MP0003315_abnormal_perineum_morphology0.88236021
58MP0003632_abnormal_nervous_system0.87168141
59MP0005360_urolithiasis0.85405147
60MP0009250_abnormal_appendicular_skeleto0.83015748
61MP0001849_ear_inflammation0.82858858
62MP0002332_abnormal_exercise_endurance0.82298537
63MP0000427_abnormal_hair_cycle0.81950082
64MP0003011_delayed_dark_adaptation0.80488868
65MP0005380_embryogenesis_phenotype0.79793231
66MP0001672_abnormal_embryogenesis/_devel0.79793231
67MP0004510_myositis0.79785864
68MP0003698_abnormal_male_reproductive0.78659566
69MP0000490_abnormal_crypts_of0.78332447
70MP0005248_abnormal_Harderian_gland0.78024061
71MP0006072_abnormal_retinal_apoptosis0.77262070
72MP0002734_abnormal_mechanical_nocicepti0.74946661
73MP0004264_abnormal_extraembryonic_tissu0.74815408
74MP0003755_abnormal_palate_morphology0.73469257
75MP0003329_amyloid_beta_deposits0.71318190
76MP0002019_abnormal_tumor_incidence0.70623755
77MP0003656_abnormal_erythrocyte_physiolo0.70570980
78MP0005666_abnormal_adipose_tissue0.66740477
79MP0002116_abnormal_craniofacial_bone0.64503971
80MP0002638_abnormal_pupillary_reflex0.64075052
81MP0002168_other_aberrant_phenotype0.62097756
82MP0005621_abnormal_cell_physiology0.60686857
83MP0003861_abnormal_nervous_system0.60659198
84MP0000538_abnormal_urinary_bladder0.60575334
85MP0008260_abnormal_autophagy0.60551370
86MP0000631_abnormal_neuroendocrine_gland0.58735294
87MP0005379_endocrine/exocrine_gland_phen0.58493483
88MP0001944_abnormal_pancreas_morphology0.58075178
89MP0008007_abnormal_cellular_replicative0.56847859
90MP0002233_abnormal_nose_morphology0.55999074
91MP0004859_abnormal_synaptic_plasticity0.55404018
92MP0004233_abnormal_muscle_weight0.54555613
93MP0003984_embryonic_growth_retardation0.54319935
94MP0005220_abnormal_exocrine_pancreas0.53736683
95MP0002088_abnormal_embryonic_growth/wei0.50341463
96MP0003091_abnormal_cell_migration0.49766145
97MP0003453_abnormal_keratinocyte_physiol0.49423695
98MP0004782_abnormal_surfactant_physiolog0.49390048
99MP0005197_abnormal_uvea_morphology0.49360817
100MP0002752_abnormal_somatic_nervous0.48999027

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.11384119
2Birth length less than 3rd percentile (HP:0003561)4.83043647
3Breast hypoplasia (HP:0003187)4.39025033
4Shawl scrotum (HP:0000049)4.31495970
5Papillary thyroid carcinoma (HP:0002895)4.30413907
6Facial hemangioma (HP:0000329)4.24269668
7Abnormality of the fingertips (HP:0001211)4.15997407
8Adrenal hypoplasia (HP:0000835)4.06230428
9Abnormality of the fovea (HP:0000493)4.02936340
10Capillary hemangiomas (HP:0005306)4.00817893
11Patellar aplasia (HP:0006443)3.85074304
12Breast aplasia (HP:0100783)3.82379294
13Arterial tortuosity (HP:0005116)3.73123066
14Aplasia/Hypoplasia of the breasts (HP:0010311)3.72296783
15Hypoplasia of the fovea (HP:0007750)3.59194793
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.59194793
17Aplasia/Hypoplasia of the patella (HP:0006498)3.52336383
18Flat capital femoral epiphysis (HP:0003370)3.39636737
19Abnormality of macular pigmentation (HP:0008002)3.23483763
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.23413262
21Infertility (HP:0000789)3.20441346
22Vascular tortuosity (HP:0004948)3.20218247
23Spondylolisthesis (HP:0003302)3.19553115
24Abnormality of lateral ventricle (HP:0030047)3.10695602
25Pendular nystagmus (HP:0012043)3.10435283
26Secondary amenorrhea (HP:0000869)2.99725959
27Chromsome breakage (HP:0040012)2.99229599
28Anterior segment dysgenesis (HP:0007700)2.94464185
29Bony spicule pigmentary retinopathy (HP:0007737)2.94037020
30Rib fusion (HP:0000902)2.88865011
31Cortical dysplasia (HP:0002539)2.74779310
32Nonprogressive disorder (HP:0003680)2.73539579
33Pancreatic fibrosis (HP:0100732)2.71759609
34Premature ovarian failure (HP:0008209)2.68674088
35Chorioretinal atrophy (HP:0000533)2.67840206
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66378884
37Lip pit (HP:0100267)2.62723476
38Congenital stationary night blindness (HP:0007642)2.61304790
39Abnormality of the phalanges of the hallux (HP:0010057)2.60162525
40Abnormality of the labia minora (HP:0012880)2.58884570
41Acute myeloid leukemia (HP:0004808)2.55403445
42Oligodactyly (HP:0012165)2.52746830
43Microglossia (HP:0000171)2.50435137
44Sandal gap (HP:0001852)2.44229072
45Absent hand (HP:0004050)2.41770871
46Primary amenorrhea (HP:0000786)2.38010694
47Aplasia/Hypoplasia of the macula (HP:0008059)2.36185242
48Oligodactyly (hands) (HP:0001180)2.36105625
49Chronic bronchitis (HP:0004469)2.35042693
50Pancreatic cysts (HP:0001737)2.33600456
51Pulmonary fibrosis (HP:0002206)2.27881799
52Camptodactyly of toe (HP:0001836)2.21860224
53Thyroid carcinoma (HP:0002890)2.18055729
54Spontaneous abortion (HP:0005268)2.17452830
55Erectile abnormalities (HP:0100639)2.16570136
56Late onset (HP:0003584)2.14689824
57Aplastic anemia (HP:0001915)2.10223967
58Posterior embryotoxon (HP:0000627)2.09329864
59Aplasia/Hypoplasia affecting the retina (HP:0008061)2.09229418
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.07812745
61Cystic hygroma (HP:0000476)2.07487499
62Abnormality of chromosome segregation (HP:0002916)2.06954451
63Hypergonadotropic hypogonadism (HP:0000815)2.04739842
64Abnormality of the line of Schwalbe (HP:0008048)2.03695499
65Hypoplastic iliac wings (HP:0002866)2.02964039
66Genu recurvatum (HP:0002816)2.01869173
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00063833
68Aplasia/Hypoplasia of the sternum (HP:0006714)1.99616450
69Carpal bone hypoplasia (HP:0001498)1.98149460
70Abnormality of the epiphysis of the femoral head (HP:0010574)1.96649203
71Gastrointestinal infarctions (HP:0005244)1.96138044
72Sparse lateral eyebrow (HP:0005338)1.94479628
73Abnormal rod and cone electroretinograms (HP:0008323)1.90206916
74Zonular cataract (HP:0010920)1.88171685
75Azoospermia (HP:0000027)1.87935610
76Hyperglycemia (HP:0003074)1.87291477
77Midline defect of the nose (HP:0004122)1.87009783
78Ventricular fibrillation (HP:0001663)1.86187122
79Myokymia (HP:0002411)1.83625703
80Oral leukoplakia (HP:0002745)1.81871865
81Long toe (HP:0010511)1.80072072
82Chin dimple (HP:0010751)1.79842091
83Deep palmar crease (HP:0006191)1.79596786
84Decreased muscle mass (HP:0003199)1.78368969
85Abnormality of the femoral head (HP:0003368)1.78173497
86Ectopic kidney (HP:0000086)1.76263997
87Abnormal spermatogenesis (HP:0008669)1.75398939
88Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.75216152
89Abnormality of femoral epiphyses (HP:0006499)1.75216152
90Insulin-resistant diabetes mellitus (HP:0000831)1.74348693
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.73394057
92Overlapping toe (HP:0001845)1.68963271
93Abnormality of the intervertebral disk (HP:0005108)1.68833211
94Anosmia (HP:0000458)1.67717074
95Retrobulbar optic neuritis (HP:0100654)1.62928269
96Optic neuritis (HP:0100653)1.62928269
97Fetal akinesia sequence (HP:0001989)1.61513163
98Cystic liver disease (HP:0006706)1.60731713
99Delayed puberty (HP:0000823)1.59331562
100Abnormality of chromosome stability (HP:0003220)1.58452882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.55848449
2LATS14.27230674
3KSR24.12864027
4LATS23.97059066
5ERBB43.73744581
6MAP3K93.41406698
7STK38L3.10284429
8MAP3K133.02641362
9TAOK12.85087096
10EEF2K2.75133387
11PLK42.71253535
12MUSK2.52107169
13RAF12.51836242
14ARAF2.50767395
15CDK82.43972705
16BRAF2.32162206
17PRKD32.00334845
18CDC71.97248179
19DYRK21.96629240
20TAOK31.83833002
21TTK1.78369147
22PAK61.64735332
23MAPKAPK31.62374024
24KSR11.59211639
25CDK91.58758611
26DMPK1.39562400
27ABL21.39427762
28MAP3K41.38973703
29STK31.34362106
30MELK1.33549942
31MOS1.32731018
32CHEK21.24892185
33PRKD21.16767612
34MAPK131.16268985
35STK381.12671266
36HIPK21.10128859
37NEK21.09059507
38MAPKAPK51.08426620
39MAP2K41.06223998
40TYRO31.04509402
41MAP2K70.96632810
42MAP3K50.84370266
43ACVR1B0.77934168
44MARK20.75820448
45RET0.75274295
46CSNK1G10.73724959
47NUAK10.69801560
48PLK10.68967849
49MAPK110.68827990
50CSNK1G20.64225505
51MAP3K10.64066147
52MAP3K80.58917309
53CDK30.58789949
54PRKAA20.58640488
55CSNK1G30.58062199
56TRPM70.52007800
57PRKAA10.51825551
58JAK30.51505897
59BRSK10.50444769
60SGK20.48326441
61CDK150.48294485
62CSNK1A1L0.45631842
63CAMK2A0.45601097
64AURKB0.45589722
65MAP3K120.44824088
66CDK180.44309577
67PLK30.40621741
68MAP3K20.40522199
69FGR0.39466367
70CDK11A0.39175135
71BUB10.36480034
72AURKA0.35477983
73RPS6KB20.34960381
74ATM0.34850510
75RPS6KA40.34398820
76NTRK20.33923559
77SGK2230.32750133
78SGK4940.32750133
79JAK20.32613348
80MAP2K10.30724637
81CHEK10.28057405
82NLK0.27730306
83STK240.26914935
84CDK140.25803276
85CDK70.24563623
86TYK20.24374256
87ABL10.21515488
88STK110.20222767
89FRK0.20124168
90PDK10.19410654
91PINK10.19075456
92SGK30.17998013
93CDK40.17681830
94CDK10.16379328
95CDK20.16203282
96STK100.15530130
97BMPR1B0.14844771
98CSNK1D0.14720884
99PDPK10.13806398
100BRSK20.13490009

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.07652182
2Vitamin B6 metabolism_Homo sapiens_hsa007503.47873867
3Circadian rhythm_Homo sapiens_hsa047103.35783628
4RNA degradation_Homo sapiens_hsa030182.97870159
5Ovarian steroidogenesis_Homo sapiens_hsa049132.84008974
6Basal transcription factors_Homo sapiens_hsa030222.69037226
7Pancreatic cancer_Homo sapiens_hsa052122.47581356
8TGF-beta signaling pathway_Homo sapiens_hsa043502.36573638
9Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.16544511
10GnRH signaling pathway_Homo sapiens_hsa049122.08403767
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04954676
12Linoleic acid metabolism_Homo sapiens_hsa005911.99090965
13Ether lipid metabolism_Homo sapiens_hsa005651.87818495
14Oocyte meiosis_Homo sapiens_hsa041141.85647371
15RNA polymerase_Homo sapiens_hsa030201.84675083
16Choline metabolism in cancer_Homo sapiens_hsa052311.80882210
17Prolactin signaling pathway_Homo sapiens_hsa049171.73833309
18Dorso-ventral axis formation_Homo sapiens_hsa043201.67332385
19Colorectal cancer_Homo sapiens_hsa052101.63787910
20Renal cell carcinoma_Homo sapiens_hsa052111.55615893
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53667204
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48954073
23VEGF signaling pathway_Homo sapiens_hsa043701.40727344
24mTOR signaling pathway_Homo sapiens_hsa041501.35584007
25Non-small cell lung cancer_Homo sapiens_hsa052231.34414010
26Long-term depression_Homo sapiens_hsa047301.31419085
27Other glycan degradation_Homo sapiens_hsa005111.29948640
28MicroRNAs in cancer_Homo sapiens_hsa052061.20211333
29Endometrial cancer_Homo sapiens_hsa052131.17184369
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16488681
31Homologous recombination_Homo sapiens_hsa034401.16189815
32p53 signaling pathway_Homo sapiens_hsa041151.15131621
33Phototransduction_Homo sapiens_hsa047441.14838331
34Bladder cancer_Homo sapiens_hsa052191.12483448
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11452451
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06628436
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03905423
38Adherens junction_Homo sapiens_hsa045201.02450462
39Glioma_Homo sapiens_hsa052140.99378629
40Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99117629
41Hippo signaling pathway_Homo sapiens_hsa043900.99114980
42Fanconi anemia pathway_Homo sapiens_hsa034600.96274065
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94847627
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.91440522
45Prostate cancer_Homo sapiens_hsa052150.91343946
46FoxO signaling pathway_Homo sapiens_hsa040680.91132787
47ErbB signaling pathway_Homo sapiens_hsa040120.90803913
48RNA transport_Homo sapiens_hsa030130.90272545
49Ras signaling pathway_Homo sapiens_hsa040140.89515612
50Thyroid cancer_Homo sapiens_hsa052160.88470673
51Hepatitis B_Homo sapiens_hsa051610.86971495
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.84760998
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82632010
54Chronic myeloid leukemia_Homo sapiens_hsa052200.80317424
55Inositol phosphate metabolism_Homo sapiens_hsa005620.79770995
56Glutamatergic synapse_Homo sapiens_hsa047240.79702144
57Estrogen signaling pathway_Homo sapiens_hsa049150.78065412
58Serotonergic synapse_Homo sapiens_hsa047260.73222309
59Mismatch repair_Homo sapiens_hsa034300.71073346
60Long-term potentiation_Homo sapiens_hsa047200.70761441
61Nucleotide excision repair_Homo sapiens_hsa034200.69744121
62Small cell lung cancer_Homo sapiens_hsa052220.69622017
63MAPK signaling pathway_Homo sapiens_hsa040100.67907782
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63896529
65Base excision repair_Homo sapiens_hsa034100.63367005
66cAMP signaling pathway_Homo sapiens_hsa040240.60586295
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59320862
68Arginine biosynthesis_Homo sapiens_hsa002200.59142667
69Melanoma_Homo sapiens_hsa052180.58308873
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58121444
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.57384585
72Shigellosis_Homo sapiens_hsa051310.53819552
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.51801037
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49453290
75Cholinergic synapse_Homo sapiens_hsa047250.48860866
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48528829
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.48382135
78Dopaminergic synapse_Homo sapiens_hsa047280.46263511
79AMPK signaling pathway_Homo sapiens_hsa041520.45900330
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.45885772
81Purine metabolism_Homo sapiens_hsa002300.44107584
82Pyrimidine metabolism_Homo sapiens_hsa002400.43750305
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42757286
84Oxytocin signaling pathway_Homo sapiens_hsa049210.42522542
85mRNA surveillance pathway_Homo sapiens_hsa030150.42412273
86Cocaine addiction_Homo sapiens_hsa050300.40615651
87Wnt signaling pathway_Homo sapiens_hsa043100.37898091
88Gap junction_Homo sapiens_hsa045400.37121201
89Notch signaling pathway_Homo sapiens_hsa043300.36629156
90DNA replication_Homo sapiens_hsa030300.35891862
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35049956
92Herpes simplex infection_Homo sapiens_hsa051680.34456685
93Melanogenesis_Homo sapiens_hsa049160.33161424
94HTLV-I infection_Homo sapiens_hsa051660.33149810
95Tight junction_Homo sapiens_hsa045300.31351893
96TNF signaling pathway_Homo sapiens_hsa046680.31119963
97Folate biosynthesis_Homo sapiens_hsa007900.28902018
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27682158
99Rap1 signaling pathway_Homo sapiens_hsa040150.26398628
100Arachidonic acid metabolism_Homo sapiens_hsa005900.26022255

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