SEC11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.34894513
2establishment of integrated proviral latency (GO:0075713)4.67751967
3* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.58406208
4* cotranslational protein targeting to membrane (GO:0006613)4.49122936
5* protein targeting to ER (GO:0045047)4.45176729
6proteasome assembly (GO:0043248)4.37150094
7viral transcription (GO:0019083)4.27116455
8protein localization to kinetochore (GO:0034501)4.26499625
9* protein localization to endoplasmic reticulum (GO:0070972)4.23627646
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)4.18818671
11translational termination (GO:0006415)4.15952518
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.11843198
13ribosomal small subunit biogenesis (GO:0042274)4.06968537
14maturation of SSU-rRNA (GO:0030490)3.91382704
15DNA deamination (GO:0045006)3.90143477
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.83771314
17ribosomal large subunit biogenesis (GO:0042273)3.73907727
18* signal peptide processing (GO:0006465)3.73675894
19antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.69932334
20translational elongation (GO:0006414)3.65504763
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.62813699
22DNA replication-independent nucleosome assembly (GO:0006336)3.59382164
23DNA replication-independent nucleosome organization (GO:0034724)3.59382164
24protein localization to chromosome, centromeric region (GO:0071459)3.54494088
25mitotic metaphase plate congression (GO:0007080)3.51549847
26establishment of viral latency (GO:0019043)3.47718027
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44586782
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43666690
29histone exchange (GO:0043486)3.43253346
30* translation (GO:0006412)3.40994909
31viral life cycle (GO:0019058)3.40158637
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34895729
33translational initiation (GO:0006413)3.34579129
34rRNA methylation (GO:0031167)3.34277237
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33985947
36ribosome assembly (GO:0042255)3.33912153
37DNA damage response, detection of DNA damage (GO:0042769)3.32434582
38antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.28720112
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28155669
40intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28155669
41regulation of cellular amino acid metabolic process (GO:0006521)3.27788148
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.27691053
43signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.27691053
44signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.27691053
45protein deneddylation (GO:0000338)3.26667473
46formation of translation preinitiation complex (GO:0001731)3.22950443
47negative regulation of ligase activity (GO:0051352)3.21476358
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21476358
49histone-serine phosphorylation (GO:0035404)3.20497143
50RNA catabolic process (GO:0006401)3.20015648
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18830826
52IMP biosynthetic process (GO:0006188)3.18682272
53cullin deneddylation (GO:0010388)3.17728144
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16595997
55Golgi transport vesicle coating (GO:0048200)3.16167646
56COPI coating of Golgi vesicle (GO:0048205)3.16167646
57telomere maintenance via semi-conservative replication (GO:0032201)3.16158611
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.14845903
59termination of RNA polymerase III transcription (GO:0006386)3.14845903
60cellular protein complex disassembly (GO:0043624)3.13737418
61signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13476930
62signal transduction involved in DNA damage checkpoint (GO:0072422)3.13476930
637-methylguanosine mRNA capping (GO:0006370)3.12329426
64RNA capping (GO:0036260)3.12328834
657-methylguanosine RNA capping (GO:0009452)3.12328834
66heterochromatin organization (GO:0070828)3.11856697
67signal transduction involved in cell cycle checkpoint (GO:0072395)3.09255079
68respiratory electron transport chain (GO:0022904)3.07671635
69oxidative phosphorylation (GO:0006119)3.06791620
70DNA ligation (GO:0006266)3.04672190
71regulation of nuclear cell cycle DNA replication (GO:0033262)3.04462092
72ribonucleoprotein complex biogenesis (GO:0022613)3.04292153
73metaphase plate congression (GO:0051310)3.02280566
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01996116
75IMP metabolic process (GO:0046040)2.97323879
76electron transport chain (GO:0022900)2.97048833
77termination of RNA polymerase II transcription (GO:0006369)2.95387487
78telomere maintenance via recombination (GO:0000722)2.95270334
79purine nucleobase biosynthetic process (GO:0009113)2.94268574
80DNA strand elongation involved in DNA replication (GO:0006271)2.90314384
81chaperone-mediated protein transport (GO:0072321)2.89925979
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89085513
83CENP-A containing nucleosome assembly (GO:0034080)2.84223420
84* protein targeting to membrane (GO:0006612)2.83436374
85nucleobase-containing small molecule interconversion (GO:0015949)2.82165359
86DNA strand elongation (GO:0022616)2.81857105
87guanosine-containing compound biosynthetic process (GO:1901070)2.80326813
88nucleobase biosynthetic process (GO:0046112)2.79840527
89positive regulation of ligase activity (GO:0051351)2.79502391
90L-serine metabolic process (GO:0006563)2.77959855
91termination of RNA polymerase I transcription (GO:0006363)2.77816420
92DNA-templated transcription, termination (GO:0006353)2.76513587
93viral mRNA export from host cell nucleus (GO:0046784)2.74087469
94protein targeting to mitochondrion (GO:0006626)2.73379539
95GTP biosynthetic process (GO:0006183)2.73043914
96transcription-coupled nucleotide-excision repair (GO:0006283)2.72310490
97regulation of mitochondrial translation (GO:0070129)2.69377035
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68482415
99cellular component biogenesis (GO:0044085)2.67970009
100spindle checkpoint (GO:0031577)2.67738577
101chromatin remodeling at centromere (GO:0031055)2.67148767
102protein neddylation (GO:0045116)2.66961630
103positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.66205909
104positive regulation of cell cycle G2/M phase transition (GO:1902751)2.66205909
105paraxial mesoderm development (GO:0048339)2.65814492
106peptidyl-histidine modification (GO:0018202)2.65697782
107spliceosomal snRNP assembly (GO:0000387)2.65654760
108mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.65440123
109regulation of mitotic spindle checkpoint (GO:1903504)2.65206130
110regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65206130
111rRNA processing (GO:0006364)2.65075267
112mitotic recombination (GO:0006312)2.64679091
113positive regulation of cell cycle arrest (GO:0071158)2.64177377
114regulation of metalloenzyme activity (GO:0048552)2.62990268
115DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.62274423
116protein complex disassembly (GO:0043241)2.62094828
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62073064
118mitotic sister chromatid segregation (GO:0000070)2.61843077
119rRNA modification (GO:0000154)2.61608605
120regulation of spindle checkpoint (GO:0090231)2.61587980
121transcription elongation from RNA polymerase I promoter (GO:0006362)2.61416837
122nuclear-transcribed mRNA catabolic process (GO:0000956)2.56983417
123transcription from RNA polymerase I promoter (GO:0006360)2.56454695
124energy coupled proton transport, down electrochemical gradient (GO:0015985)2.55405428
125ATP synthesis coupled proton transport (GO:0015986)2.55405428
126rRNA metabolic process (GO:0016072)2.53794015
127kinetochore organization (GO:0051383)2.51752296
128macromolecular complex disassembly (GO:0032984)2.51594270
129protein complex biogenesis (GO:0070271)2.51045374
130spliceosomal complex assembly (GO:0000245)2.50490263
131L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48833143
132DNA replication checkpoint (GO:0000076)2.46442183
133respiratory chain complex IV assembly (GO:0008535)2.46233288
134kinetochore assembly (GO:0051382)2.44942468
135mRNA catabolic process (GO:0006402)2.44503830
136GDP-mannose metabolic process (GO:0019673)2.44351875
137cell cycle G1/S phase transition (GO:0044843)2.44271716
138G1/S transition of mitotic cell cycle (GO:0000082)2.44271716
139transcription elongation from RNA polymerase II promoter (GO:0006368)2.42738669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.45323134
2E2F7_22180533_ChIP-Seq_HELA_Human4.42552289
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.26167552
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.74853594
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.71959002
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53169188
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.29618173
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.22786439
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.08208930
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07746256
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07624322
12VDR_23849224_ChIP-Seq_CD4+_Human2.69743783
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63456859
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60553785
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50145630
16ELK1_19687146_ChIP-ChIP_HELA_Human2.48834126
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48041541
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45998065
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45583162
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37537958
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.37012036
22* DCP1A_22483619_ChIP-Seq_HELA_Human2.35586203
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.27664014
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26518581
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23511776
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17875524
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.17073745
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16219337
29IRF8_22096565_ChIP-ChIP_GC-B_Human2.15782377
30FOXP3_21729870_ChIP-Seq_TREG_Human2.15564663
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13980314
32XRN2_22483619_ChIP-Seq_HELA_Human2.09944061
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08631484
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08343795
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07657947
36HOXB4_20404135_ChIP-ChIP_EML_Mouse2.06560621
37* GABP_19822575_ChIP-Seq_HepG2_Human1.94256157
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94041608
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87146599
40TTF2_22483619_ChIP-Seq_HELA_Human1.86196035
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79610814
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78577125
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.75064580
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74319189
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61036438
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58816647
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55905832
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54389655
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.54037078
50* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53213411
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52300068
52* SPI1_23547873_ChIP-Seq_NB4_Human1.43784118
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42945827
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.40102826
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39407379
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38953119
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38953119
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38953119
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38182789
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37988840
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.37378310
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35941514
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.34987042
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34519928
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33888766
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33188907
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31583807
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.31391477
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.30029160
70* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28207247
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27908383
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27827401
73AR_21909140_ChIP-Seq_LNCAP_Human1.27244220
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.26312926
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25764953
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25198693
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22273691
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.21650611
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21390510
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20696306
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19968057
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19189781
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19170225
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18052383
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16003795
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11940344
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11176429
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11043004
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08953778
90CIITA_25753668_ChIP-Seq_RAJI_Human1.08252005
91TFEB_21752829_ChIP-Seq_HELA_Human1.08064564
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06360180
93* KDM5A_27292631_Chip-Seq_BREAST_Human1.05128662
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04863871
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.04465635
96* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04462418
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04177718
98ZNF263_19887448_ChIP-Seq_K562_Human1.01741230
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99168820
100MYC_18940864_ChIP-ChIP_HL60_Human0.99076036
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96826120
102SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96418057
103EWS_26573619_Chip-Seq_HEK293_Human0.96363499
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95374305
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94320584
106NANOG_21062744_ChIP-ChIP_HESCs_Human0.93863830
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93148199
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92194869
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.92085361
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92026586
111WT1_19549856_ChIP-ChIP_CCG9911_Human0.91013444
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88307146
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88072785
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.87176687
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86894301
116* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85738509
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84613408
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83794837
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83611831
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83176236
121* CHD1_26751641_Chip-Seq_LNCaP_Human0.83154168
122GATA1_22025678_ChIP-Seq_K562_Human0.80643584
123MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79899408
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79224418
125* MYB_26560356_Chip-Seq_TH2_Human0.78415873
126EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75568905
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.73172146
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.72656254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.83185286
2MP0010030_abnormal_orbit_morphology3.35213259
3MP0004957_abnormal_blastocyst_morpholog2.59422816
4MP0009053_abnormal_anal_canal2.58752776
5MP0001835_abnormal_antigen_presentation2.55937943
6MP0006054_spinal_hemorrhage2.47832267
7MP0003724_increased_susceptibility_to2.21025809
8MP0004272_abnormal_basement_membrane2.14231778
9MP0009785_altered_susceptibility_to2.08936163
10MP0005671_abnormal_response_to2.03029258
11MP0003186_abnormal_redox_activity2.01190299
12MP0000537_abnormal_urethra_morphology2.01118461
13MP0003077_abnormal_cell_cycle2.00021330
14MP0001293_anophthalmia1.99426567
15MP0009379_abnormal_foot_pigmentation1.98780828
16MP0009333_abnormal_splenocyte_physiolog1.97130100
17MP0008007_abnormal_cellular_replicative1.94256457
18MP0003806_abnormal_nucleotide_metabolis1.93482801
19MP0008058_abnormal_DNA_repair1.92721852
20MP0009697_abnormal_copulation1.92389145
21MP0002148_abnormal_hypersensitivity_rea1.91086706
22MP0010094_abnormal_chromosome_stability1.84597991
23MP0003763_abnormal_thymus_physiology1.84504291
24MP0009672_abnormal_birth_weight1.70286022
25MP0005503_abnormal_tendon_morphology1.69858605
26MP0003705_abnormal_hypodermis_morpholog1.68744582
27MP0005408_hypopigmentation1.64716505
28MP0008932_abnormal_embryonic_tissue1.61917592
29MP0008438_abnormal_cutaneous_collagen1.60566512
30MP0003567_abnormal_fetal_cardiomyocyte1.59649861
31MP0003111_abnormal_nucleus_morphology1.58896736
32MP0002697_abnormal_eye_size1.58581227
33MP0003786_premature_aging1.58355372
34MP0003436_decreased_susceptibility_to1.57740904
35MP0008057_abnormal_DNA_replication1.55226825
36MP0000490_abnormal_crypts_of1.54818795
37MP0005084_abnormal_gallbladder_morpholo1.54668176
38MP0000350_abnormal_cell_proliferation1.54178546
39MP0001697_abnormal_embryo_size1.52522925
40MP0001730_embryonic_growth_arrest1.51352734
41MP0005000_abnormal_immune_tolerance1.48259618
42MP0001286_abnormal_eye_development1.47377201
43MP0005025_abnormal_response_to1.45937561
44MP0001853_heart_inflammation1.44509850
45MP0000685_abnormal_immune_system1.44329014
46MP0002085_abnormal_embryonic_tissue1.44307152
47MP0003136_yellow_coat_color1.40525663
48MP0002163_abnormal_gland_morphology1.40297006
49MP0003937_abnormal_limbs/digits/tail_de1.39493865
50MP0002452_abnormal_antigen_presenting1.35687558
51MP0005380_embryogenesis_phenotype1.35227817
52MP0001672_abnormal_embryogenesis/_devel1.35227817
53MP0002396_abnormal_hematopoietic_system1.35186378
54MP0002132_abnormal_respiratory_system1.34670354
55MP0002084_abnormal_developmental_patter1.33189723
56MP0002723_abnormal_immune_serum1.32967429
57MP0000858_altered_metastatic_potential1.31778271
58MP0002420_abnormal_adaptive_immunity1.31204040
59MP0005197_abnormal_uvea_morphology1.31192811
60MP0001819_abnormal_immune_cell1.31022034
61MP0005257_abnormal_intraocular_pressure1.30300683
62MP0003890_abnormal_embryonic-extraembry1.30096813
63MP0002419_abnormal_innate_immunity1.30079416
64MP0001800_abnormal_humoral_immune1.30074199
65MP0005220_abnormal_exocrine_pancreas1.29505521
66MP0003718_maternal_effect1.27862920
67MP0006292_abnormal_olfactory_placode1.27517910
68MP0003984_embryonic_growth_retardation1.26650893
69MP0000358_abnormal_cell_content/1.26612875
70MP0002938_white_spotting1.26070521
71MP0002166_altered_tumor_susceptibility1.25663496
72MP0003123_paternal_imprinting1.25239981
73MP0002088_abnormal_embryonic_growth/wei1.22754345
74MP0004782_abnormal_surfactant_physiolog1.22496684
75MP0005387_immune_system_phenotype1.22088627
76MP0001790_abnormal_immune_system1.22088627
77MP0002111_abnormal_tail_morphology1.21579214
78MP0002405_respiratory_system_inflammati1.21433361
79MP0002398_abnormal_bone_marrow1.20168784
80MP0002080_prenatal_lethality1.18465342
81MP0002006_tumorigenesis1.16751882
82MP0002933_joint_inflammation1.16572120
83MP0001764_abnormal_homeostasis1.16052925
84MP0001845_abnormal_inflammatory_respons1.15420186
85MP0002233_abnormal_nose_morphology1.14679361
86MP0001542_abnormal_bone_strength1.13521743
87MP0010368_abnormal_lymphatic_system1.12944990
88MP0006082_CNS_inflammation1.12878666
89MP0010155_abnormal_intestine_physiology1.12421016
90MP0000716_abnormal_immune_system1.11525189
91MP0002877_abnormal_melanocyte_morpholog1.11304969
92MP0003942_abnormal_urinary_system1.08313513
93MP0002429_abnormal_blood_cell1.07867130
94MP0005501_abnormal_skin_physiology1.06925618
95MP0002722_abnormal_immune_system1.05586844
96MP0005379_endocrine/exocrine_gland_phen1.05293618
97MP0000762_abnormal_tongue_morphology1.04043303
98MP0004197_abnormal_fetal_growth/weight/1.03817159
99MP0010386_abnormal_urinary_bladder1.03608745
100MP0001533_abnormal_skeleton_physiology1.03372303
101MP0009703_decreased_birth_body1.03094061
102MP0002254_reproductive_system_inflammat1.02985245
103MP0008469_abnormal_protein_level1.02085501
104MP0000689_abnormal_spleen_morphology1.01843149
105MP0009250_abnormal_appendicular_skeleto1.00334677
106MP0010307_abnormal_tumor_latency0.99601184
107MP0000516_abnormal_urinary_system0.99138956
108MP0005367_renal/urinary_system_phenotyp0.99138956
109MP0002092_abnormal_eye_morphology0.98584362
110MP0000049_abnormal_middle_ear0.98566747
111MP0002086_abnormal_extraembryonic_tissu0.97383975
112MP0004264_abnormal_extraembryonic_tissu0.96720564
113MP0000372_irregular_coat_pigmentation0.95803001
114MP0002138_abnormal_hepatobiliary_system0.95089191
115MP0001881_abnormal_mammary_gland0.94948117
116MP0005636_abnormal_mineral_homeostasis0.91934538
117MP0003866_abnormal_defecation0.91726132
118MP0003755_abnormal_palate_morphology0.91098626
119MP0004185_abnormal_adipocyte_glucose0.90794681
120MP0003943_abnormal_hepatobiliary_system0.89841436
121MP0002019_abnormal_tumor_incidence0.89606582
122MP0000613_abnormal_salivary_gland0.89519478
123MP0004808_abnormal_hematopoietic_stem0.89266712
124MP0002796_impaired_skin_barrier0.89055189
125MP0002693_abnormal_pancreas_physiology0.88603091
126MP0003315_abnormal_perineum_morphology0.88408277
127MP0005390_skeleton_phenotype0.86539979
128MP0001119_abnormal_female_reproductive0.85643212
129MP0003119_abnormal_digestive_system0.85632635
130MP0005193_abnormal_anterior_eye0.85540606
131MP0002277_abnormal_respiratory_mucosa0.84417605
132MP0008004_abnormal_stomach_pH0.83828354
133MP0000678_abnormal_parathyroid_gland0.83108810
134MP0009384_cardiac_valve_regurgitation0.81279048
135MP0000703_abnormal_thymus_morphology0.80524261
136MP0003385_abnormal_body_wall0.80214908
137MP0001346_abnormal_lacrimal_gland0.80172610
138MP0000432_abnormal_head_morphology0.79948907
139MP0006036_abnormal_mitochondrial_physio0.79940585
140MP0009643_abnormal_urine_homeostasis0.79588676
141MP0006072_abnormal_retinal_apoptosis0.79427035
142MP0003941_abnormal_skin_development0.78473679
143MP0001545_abnormal_hematopoietic_system0.78348260
144MP0005397_hematopoietic_system_phenotyp0.78348260
145MP0000428_abnormal_craniofacial_morphol0.78108720
146MP0001756_abnormal_urination0.76362771
147MP0000313_abnormal_cell_death0.75532869
148MP0000465_gastrointestinal_hemorrhage0.75173944
149MP0001879_abnormal_lymphatic_vessel0.75042675
150MP0005023_abnormal_wound_healing0.74910924
151MP0003795_abnormal_bone_structure0.74060923
152MP0002210_abnormal_sex_determination0.73429404
153MP0000750_abnormal_muscle_regeneration0.73256634
154MP0001243_abnormal_dermal_layer0.72815630
155MP0005464_abnormal_platelet_physiology0.72677804
156MP0005058_abnormal_lysosome_morphology0.72348620
157MP0002928_abnormal_bile_duct0.72268544
158MP0005275_abnormal_skin_tensile0.72065941
159MP0000538_abnormal_urinary_bladder0.71175807
160MP0002060_abnormal_skin_morphology0.69835635
161MP0001145_abnormal_male_reproductive0.67411997
162MP0003935_abnormal_craniofacial_develop0.67152894
163MP0003936_abnormal_reproductive_system0.67007911
164MP0000627_abnormal_mammary_gland0.65328099
165MP0003566_abnormal_cell_adhesion0.64051947
166MP0005647_abnormal_sex_gland0.63800599
167MP0001661_extended_life_span0.63246665
168MP0005384_cellular_phenotype0.61591892
169MP0006035_abnormal_mitochondrial_morpho0.61453635
170MP0004233_abnormal_muscle_weight0.61020600
171MP0005076_abnormal_cell_differentiation0.60929382

Predicted human phenotypes

RankGene SetZ-score
1Upper motor neuron abnormality (HP:0002127)4.30967675
2Reticulocytopenia (HP:0001896)3.93376848
3Abnormality of the lower motor neuron (HP:0002366)3.73002144
4Abnormality of cells of the erythroid lineage (HP:0012130)3.53153609
5Aplastic anemia (HP:0001915)3.51306378
6Stenosis of the external auditory canal (HP:0000402)3.51043946
7Abnormal number of erythroid precursors (HP:0012131)3.47295332
8Type I transferrin isoform profile (HP:0003642)3.43228679
9Conjunctival telangiectasia (HP:0000524)3.04196683
10Reduced antithrombin III activity (HP:0001976)2.98655126
11Acute necrotizing encephalopathy (HP:0006965)2.95843104
12Abnormal lung lobation (HP:0002101)2.89063283
13Generalized aminoaciduria (HP:0002909)2.76263682
14Macrocytic anemia (HP:0001972)2.74704825
15Hepatic necrosis (HP:0002605)2.74191958
16Mitochondrial inheritance (HP:0001427)2.72630308
17Abnormal mitochondria in muscle tissue (HP:0008316)2.70280621
18Abnormality of the vasculature of the conjunctiva (HP:0008054)2.69210983
19Thrombocytosis (HP:0001894)2.69020841
20Impaired proprioception (HP:0010831)2.67648559
21Birth length less than 3rd percentile (HP:0003561)2.67629819
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66594589
23Abnormal protein N-linked glycosylation (HP:0012347)2.66594589
24Abnormal protein glycosylation (HP:0012346)2.66594589
25Abnormal glycosylation (HP:0012345)2.66594589
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60070509
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60070509
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59367126
2911 pairs of ribs (HP:0000878)2.59228924
30Rectovaginal fistula (HP:0000143)2.58952295
31Rectal fistula (HP:0100590)2.58952295
32Hepatocellular necrosis (HP:0001404)2.54446247
333-Methylglutaconic aciduria (HP:0003535)2.52871122
34Vacuolated lymphocytes (HP:0001922)2.52330930
35Amyotrophic lateral sclerosis (HP:0007354)2.52080626
36Pallor (HP:0000980)2.50216968
37Partial duplication of the phalanx of hand (HP:0009999)2.48996923
38Chromsome breakage (HP:0040012)2.48043980
39Rough bone trabeculation (HP:0100670)2.46423544
40Acute encephalopathy (HP:0006846)2.44576608
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43076092
42Abnormality of methionine metabolism (HP:0010901)2.42852990
43Increased CSF lactate (HP:0002490)2.37801577
44Poor head control (HP:0002421)2.36769172
45Partial duplication of thumb phalanx (HP:0009944)2.34811135
46Atrophy/Degeneration involving motor neurons (HP:0007373)2.34466384
47Abnormality of the anterior horn cell (HP:0006802)2.33082484
48Degeneration of anterior horn cells (HP:0002398)2.33082484
49Lipid accumulation in hepatocytes (HP:0006561)2.32695775
50IgM deficiency (HP:0002850)2.31854329
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30304846
52Irregular epiphyses (HP:0010582)2.28979056
53Vaginal fistula (HP:0004320)2.28481691
54Progressive macrocephaly (HP:0004481)2.28250758
55Increased hepatocellular lipid droplets (HP:0006565)2.27412759
56Meckel diverticulum (HP:0002245)2.26820696
57Septo-optic dysplasia (HP:0100842)2.26588409
58Triphalangeal thumb (HP:0001199)2.21250381
59Facial cleft (HP:0002006)2.19164344
60Elevated erythrocyte sedimentation rate (HP:0003565)2.17653094
61Microvesicular hepatic steatosis (HP:0001414)2.14816848
62Increased serum lactate (HP:0002151)2.12240193
63Selective tooth agenesis (HP:0001592)2.11645587
64Hyperglycinemia (HP:0002154)2.11069972
65Congenital, generalized hypertrichosis (HP:0004540)2.09630113
66Abnormality of serum amino acid levels (HP:0003112)2.09116054
67Flat capital femoral epiphysis (HP:0003370)2.07541425
68Exertional dyspnea (HP:0002875)2.07479421
69Abnormality of the ileum (HP:0001549)2.06799861
70Duplication of thumb phalanx (HP:0009942)2.06644752
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05308727
72Abnormal number of incisors (HP:0011064)2.05101701
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04400403
74Microretrognathia (HP:0000308)2.03844648
75Pancytopenia (HP:0001876)2.03359040
76Oral leukoplakia (HP:0002745)2.01343580
77Abnormality of urine glucose concentration (HP:0011016)2.01294265
78Glycosuria (HP:0003076)2.01294265
79Abnormal trabecular bone morphology (HP:0100671)2.01063095
80Recurrent abscess formation (HP:0002722)1.99147441
81Carpal bone hypoplasia (HP:0001498)1.97988132
82Absent thumb (HP:0009777)1.96408782
83Renal Fanconi syndrome (HP:0001994)1.96143517
84Rib fusion (HP:0000902)1.96133287
85Petechiae (HP:0000967)1.95047423
86Abnormality of chromosome stability (HP:0003220)1.93210346
87Abnormal pancreas size (HP:0012094)1.91550006
88Hypothermia (HP:0002045)1.91028928
89Breast hypoplasia (HP:0003187)1.90038197
90Increased IgM level (HP:0003496)1.88732659
91Secondary amenorrhea (HP:0000869)1.86484098
92Calcaneovalgus deformity (HP:0001848)1.86344485
93Exercise intolerance (HP:0003546)1.85789263
94Intestinal fistula (HP:0100819)1.85338033
95IgG deficiency (HP:0004315)1.85314811
96Arterial tortuosity (HP:0005116)1.84082419
97Short middle phalanx of the 5th finger (HP:0004220)1.82301066
98Abnormality of the labia minora (HP:0012880)1.81432337
99Nephroblastoma (Wilms tumor) (HP:0002667)1.81431786
100Autoimmune hemolytic anemia (HP:0001890)1.80808433
101Trismus (HP:0000211)1.80729904
102Abnormal hemoglobin (HP:0011902)1.80335080
103Neoplasm of the colon (HP:0100273)1.79979123
104Delayed epiphyseal ossification (HP:0002663)1.79150585
105Premature rupture of membranes (HP:0001788)1.79042175
106Cleft eyelid (HP:0000625)1.78510778
107Premature graying of hair (HP:0002216)1.78506519
108Granulocytopenia (HP:0001913)1.77300576
109Abnormality of glycolysis (HP:0004366)1.76991030
110Deformed tarsal bones (HP:0008119)1.76758714
111Abnormality of T cell physiology (HP:0011840)1.76038075
112Small intestinal stenosis (HP:0012848)1.75895383
113Duodenal stenosis (HP:0100867)1.75895383
114True hermaphroditism (HP:0010459)1.75874965
115Neutropenia (HP:0001875)1.75747371
116Absent septum pellucidum (HP:0001331)1.75534367
117Pancreatic cysts (HP:0001737)1.74849916
118Lactic acidosis (HP:0003128)1.74289003
119Abnormality of placental membranes (HP:0011409)1.73274228
120Amniotic constriction ring (HP:0009775)1.73274228
121Increased serum pyruvate (HP:0003542)1.73116454
122Leukodystrophy (HP:0002415)1.72205389
123Irregular vertebral endplates (HP:0003301)1.71710538
124Depressed nasal ridge (HP:0000457)1.71638406
125Megaloblastic anemia (HP:0001889)1.71636072
126Embryonal renal neoplasm (HP:0011794)1.71125091
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.71005577
128Beaking of vertebral bodies (HP:0004568)1.70643113
129Recurrent bacterial skin infections (HP:0005406)1.69151633
130Myositis (HP:0100614)1.69064948
131Sparse eyelashes (HP:0000653)1.68885307
132Cervical subluxation (HP:0003308)1.68877812
133Bone marrow hypocellularity (HP:0005528)1.68805620
134Severe combined immunodeficiency (HP:0004430)1.67037708
135Multiple enchondromatosis (HP:0005701)1.66974679
136Abnormality of T cells (HP:0002843)1.66641784
137Abnormality of the duodenum (HP:0002246)1.66160859
138Proximal tubulopathy (HP:0000114)1.66056872
139Eczematoid dermatitis (HP:0000976)1.65180801
140Vascular tortuosity (HP:0004948)1.63252782
141Respiratory failure (HP:0002878)1.63095662
142Horseshoe kidney (HP:0000085)1.62885743
143Pancreatic fibrosis (HP:0100732)1.62344507
144Lymphoma (HP:0002665)1.60528354
145Increased intramyocellular lipid droplets (HP:0012240)1.60149395
146Colon cancer (HP:0003003)1.59610887
147Eosinophilia (HP:0001880)1.59326360
148Aplasia/hypoplasia of the uterus (HP:0008684)1.59141758
149Small epiphyses (HP:0010585)1.57649599
150Hypoglycemic coma (HP:0001325)1.57244526
151Cerebral edema (HP:0002181)1.56872731
152Patellar aplasia (HP:0006443)1.56785633
153Abnormality of eosinophils (HP:0001879)1.56717503
154Combined immunodeficiency (HP:0005387)1.56364581
155Respiratory difficulties (HP:0002880)1.56348196
156Type 2 muscle fiber atrophy (HP:0003554)1.55251617
157Abnormality of the preputium (HP:0100587)1.54538391
158Renal cortical cysts (HP:0000803)1.54286552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.92313302
2NME23.52927915
3STK163.31048111
4BUB13.04820281
5EIF2AK32.81584172
6EIF2AK12.74574956
7TAF12.70290579
8NEK12.64158367
9VRK12.45901416
10CDK62.28928099
11EPHB22.17900574
12PIM22.17826781
13MST42.14302752
14SRPK12.09773392
15PASK2.06644842
16TXK1.99934713
17WEE11.95213061
18ACVR1B1.90575059
19IRAK31.80831994
20PLK41.78175748
21IRAK41.66665295
22PBK1.62854288
23KDR1.60581943
24TNIK1.60444456
25BRSK21.57508059
26ZAK1.49637160
27PAK41.42111754
28BCR1.41839289
29TEC1.40544074
30RPS6KA41.39491322
31DYRK31.38048442
32CDK41.37462778
33FRK1.35725795
34STK31.33068559
35TRIM281.32056309
36NUAK11.31659906
37CDK191.30411476
38PDK21.27411639
39TGFBR11.25779667
40MAP4K11.25469998
41MYLK1.25314655
42MAP3K141.25093533
43EIF2AK21.24692769
44TLK11.22870270
45SCYL21.21111508
46CDK81.19615864
47ZAP701.18914279
48FLT31.18393945
49MKNK11.17295838
50NLK1.17164242
51CDC71.12689868
52AURKB1.11716412
53MAP3K31.10349669
54TESK11.09799590
55BMPR1B1.09751472
56TBK11.09598530
57LATS21.09172160
58JAK31.08494016
59ERBB41.07676471
60ILK1.06860145
61TSSK61.04729217
62LATS11.03673990
63TYK21.02636991
64IKBKE1.02190785
65BCKDK1.01396682
66PLK31.01196525
67MAPK150.99964980
68PLK10.99552302
69TIE10.99476983
70IKBKB0.99101245
71TESK20.95652694
72ALK0.95449515
73BLK0.95168672
74PIK3CG0.93468528
75KIT0.89438593
76BRAF0.89221751
77MAP3K120.89134043
78STK38L0.88444563
79ERBB30.87550342
80MKNK20.86502749
81CCNB10.84242363
82ARAF0.83706169
83SIK30.82103701
84PIM10.81730813
85NEK90.81569704
86BMPR20.79137506
87CDK70.77672840
88NME10.73951542
89TAOK30.72820703
90BTK0.72680256
91MAP3K100.72577394
92ATR0.72319385
93CSNK2A10.72249219
94FGFR10.71885818
95ABL20.70449973
96STK100.70335949
97DYRK20.70048692
98EPHA20.69338819
99LIMK10.69267665
100CHEK10.68775733
101AURKA0.68161525
102ERN10.67396197
103MAP3K110.67367200
104LYN0.66570155
105YES10.66485854
106PNCK0.64665542
107CHUK0.63488143
108CLK10.61891552
109MAP2K30.61067921
110TTK0.58805934
111ITK0.57395644
112STK240.55960076
113LRRK20.54339008
114NEK20.54294476
115RPS6KB20.53189528
116SMG10.52636712
117BRSK10.51851056
118PAK20.51578431
119ATM0.50527874
120RPS6KA50.50465661
121CSNK2A20.47347071
122MOS0.47253279
123PAK10.46571833
124LCK0.46207177
125STK40.44307219
126PRKG20.43275698
127CHEK20.42942544
128PLK20.42891381
129CDK10.42566148
130SYK0.42185866
131ADRBK20.40114111
132MAP3K80.39899489
133IRAK10.39782202
134TGFBR20.39093018
135CSNK1E0.37643671
136CDK20.30019007
137CSNK1G10.28837702
138MET0.27887124
139CDK90.23350673
140PRKCI0.22210633
141DAPK30.20786430
142NTRK10.20542817
143MELK0.19306134

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.07518470
2Ribosome_Homo sapiens_hsa030104.04641183
3* Protein export_Homo sapiens_hsa030604.02863713
4RNA polymerase_Homo sapiens_hsa030203.09605490
5DNA replication_Homo sapiens_hsa030302.92141244
6Mismatch repair_Homo sapiens_hsa034302.39920259
7Pyrimidine metabolism_Homo sapiens_hsa002402.34642607
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19748451
9Spliceosome_Homo sapiens_hsa030402.13632924
10Homologous recombination_Homo sapiens_hsa034402.12315605
11Nucleotide excision repair_Homo sapiens_hsa034202.04059475
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03716336
13Base excision repair_Homo sapiens_hsa034101.91341837
14Oxidative phosphorylation_Homo sapiens_hsa001901.78094733
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.76848214
16Basal transcription factors_Homo sapiens_hsa030221.64748454
17RNA transport_Homo sapiens_hsa030131.63778750
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.58167525
19Parkinsons disease_Homo sapiens_hsa050121.54644267
20Folate biosynthesis_Homo sapiens_hsa007901.52013155
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45876149
22Antigen processing and presentation_Homo sapiens_hsa046121.44770986
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42283514
24RNA degradation_Homo sapiens_hsa030181.37939533
25Pyruvate metabolism_Homo sapiens_hsa006201.35884918
26One carbon pool by folate_Homo sapiens_hsa006701.33767155
27Cell cycle_Homo sapiens_hsa041101.33107844
28Non-homologous end-joining_Homo sapiens_hsa034501.32229696
29Fanconi anemia pathway_Homo sapiens_hsa034601.32219224
30Huntingtons disease_Homo sapiens_hsa050161.26244070
31Purine metabolism_Homo sapiens_hsa002301.23527416
32Graft-versus-host disease_Homo sapiens_hsa053321.22397725
33Steroid biosynthesis_Homo sapiens_hsa001001.21156520
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20754505
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17556024
36Legionellosis_Homo sapiens_hsa051341.16018533
37Allograft rejection_Homo sapiens_hsa053301.14146097
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14040598
39Biosynthesis of amino acids_Homo sapiens_hsa012301.13443251
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13272536
41N-Glycan biosynthesis_Homo sapiens_hsa005101.13121997
42Sulfur metabolism_Homo sapiens_hsa009201.13066325
43Propanoate metabolism_Homo sapiens_hsa006401.12644627
44Carbon metabolism_Homo sapiens_hsa012001.11103709
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.08105681
46Other glycan degradation_Homo sapiens_hsa005111.06504921
47Primary immunodeficiency_Homo sapiens_hsa053401.06475463
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.02670051
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01485284
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00938482
51Fatty acid elongation_Homo sapiens_hsa000621.00094847
52p53 signaling pathway_Homo sapiens_hsa041150.97301789
53Asthma_Homo sapiens_hsa053100.94039305
54Cardiac muscle contraction_Homo sapiens_hsa042600.91350915
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89583783
56Herpes simplex infection_Homo sapiens_hsa051680.87554867
57Alzheimers disease_Homo sapiens_hsa050100.87299669
58Selenocompound metabolism_Homo sapiens_hsa004500.86509044
59Epstein-Barr virus infection_Homo sapiens_hsa051690.86205334
60Autoimmune thyroid disease_Homo sapiens_hsa053200.85634104
61Hematopoietic cell lineage_Homo sapiens_hsa046400.84123110
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80598048
63Arachidonic acid metabolism_Homo sapiens_hsa005900.79492364
64Sulfur relay system_Homo sapiens_hsa041220.79113466
65Glutathione metabolism_Homo sapiens_hsa004800.78950403
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.78913244
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77821152
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76950595
69Pentose phosphate pathway_Homo sapiens_hsa000300.76835667
70Measles_Homo sapiens_hsa051620.76715640
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75713799
72Basal cell carcinoma_Homo sapiens_hsa052170.74860204
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73521000
74Thyroid cancer_Homo sapiens_hsa052160.68099515
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68088141
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67536261
77TGF-beta signaling pathway_Homo sapiens_hsa043500.66807785
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66591801
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65352077
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64443677
81Leishmaniasis_Homo sapiens_hsa051400.63994752
82Galactose metabolism_Homo sapiens_hsa000520.60507283
83Regulation of autophagy_Homo sapiens_hsa041400.59751426
84Malaria_Homo sapiens_hsa051440.55134380
85Metabolic pathways_Homo sapiens_hsa011000.54688507
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53550703
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52690365
88Vibrio cholerae infection_Homo sapiens_hsa051100.52315784
89Type I diabetes mellitus_Homo sapiens_hsa049400.51820047
90Vitamin B6 metabolism_Homo sapiens_hsa007500.51533132
91Systemic lupus erythematosus_Homo sapiens_hsa053220.51389116
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.50838574
93Hedgehog signaling pathway_Homo sapiens_hsa043400.50256078
94Rheumatoid arthritis_Homo sapiens_hsa053230.49547032
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49027941
96Hippo signaling pathway_Homo sapiens_hsa043900.48647565
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48507144
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47778784
99Phagosome_Homo sapiens_hsa041450.46120969
100Apoptosis_Homo sapiens_hsa042100.43757870
101Renin-angiotensin system_Homo sapiens_hsa046140.42743498
102Lysosome_Homo sapiens_hsa041420.42650975
103Sphingolipid metabolism_Homo sapiens_hsa006000.42507539
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41696013
105mRNA surveillance pathway_Homo sapiens_hsa030150.40771197
106Pertussis_Homo sapiens_hsa051330.40121798
107Influenza A_Homo sapiens_hsa051640.39450944
108Vitamin digestion and absorption_Homo sapiens_hsa049770.39333495
109Shigellosis_Homo sapiens_hsa051310.37330649
110beta-Alanine metabolism_Homo sapiens_hsa004100.36727136
111Peroxisome_Homo sapiens_hsa041460.35946382
112HTLV-I infection_Homo sapiens_hsa051660.35832305
113Oocyte meiosis_Homo sapiens_hsa041140.35565027
114Adherens junction_Homo sapiens_hsa045200.34635523
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34348749
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.34127647
117Viral carcinogenesis_Homo sapiens_hsa052030.31356147
118Histidine metabolism_Homo sapiens_hsa003400.30844829
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30467008
120Wnt signaling pathway_Homo sapiens_hsa043100.30414928
121Fructose and mannose metabolism_Homo sapiens_hsa000510.29112243
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28827127
123Hepatitis B_Homo sapiens_hsa051610.25928209
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25698760
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25023735
126Staphylococcus aureus infection_Homo sapiens_hsa051500.23439560
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23039196
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22354713
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22103526
130ECM-receptor interaction_Homo sapiens_hsa045120.21811302
131Small cell lung cancer_Homo sapiens_hsa052220.21791306
132Bladder cancer_Homo sapiens_hsa052190.21434780
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.18582592
134MicroRNAs in cancer_Homo sapiens_hsa052060.17738510
135Fat digestion and absorption_Homo sapiens_hsa049750.14737980
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14524732
137Tight junction_Homo sapiens_hsa045300.13426004
138Protein digestion and absorption_Homo sapiens_hsa049740.12482547
139Arginine and proline metabolism_Homo sapiens_hsa003300.12093552
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.11853679
141Pathways in cancer_Homo sapiens_hsa052000.11095979
142Colorectal cancer_Homo sapiens_hsa052100.10801911
143Starch and sucrose metabolism_Homo sapiens_hsa005000.10316314

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