SEC11B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.41978923
2protein prenylation (GO:0018342)6.24427078
3prenylation (GO:0097354)6.24427078
4valine metabolic process (GO:0006573)6.12740945
5viral transcription (GO:0019083)6.10910525
6translational termination (GO:0006415)5.97199746
7positive regulation of uterine smooth muscle contraction (GO:0070474)5.62812862
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.57971801
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.50587890
10single strand break repair (GO:0000012)5.50446238
11protein targeting to ER (GO:0045047)5.49731600
12cotranslational protein targeting to membrane (GO:0006613)5.48030669
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.25991247
14protein localization to endoplasmic reticulum (GO:0070972)5.15035125
15DNA deamination (GO:0045006)5.08160598
16translational elongation (GO:0006414)5.07455103
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.87341094
18ATP synthesis coupled proton transport (GO:0015986)4.87341094
19ribosomal small subunit biogenesis (GO:0042274)4.70222281
20seminiferous tubule development (GO:0072520)4.69763254
21ribosomal large subunit biogenesis (GO:0042273)4.68671834
22otic vesicle formation (GO:0030916)4.63233854
23branched-chain amino acid catabolic process (GO:0009083)4.58991556
24viral life cycle (GO:0019058)4.54931200
25regulation of uterine smooth muscle contraction (GO:0070472)4.40069819
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.32185800
27maturation of SSU-rRNA (GO:0030490)4.30730946
28cellular protein complex disassembly (GO:0043624)4.30407840
29translational initiation (GO:0006413)4.28032728
30protein neddylation (GO:0045116)4.17110063
31cytochrome complex assembly (GO:0017004)4.14270475
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.07591808
33negative regulation of norepinephrine secretion (GO:0010700)4.02012125
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.01431019
35regulation of mitochondrial translation (GO:0070129)4.00357857
36cytokinetic process (GO:0032506)3.96394035
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.94285241
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.94285241
39respiratory electron transport chain (GO:0022904)3.90553561
40macroautophagy (GO:0016236)3.89333837
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.85145183
42electron transport chain (GO:0022900)3.81624033
43phospholipid scrambling (GO:0017121)3.71548867
44translation (GO:0006412)3.66872229
45protein complex biogenesis (GO:0070271)3.66682165
46branched-chain amino acid metabolic process (GO:0009081)3.66116233
47rRNA methylation (GO:0031167)3.64447876
48negative regulation of transcription regulatory region DNA binding (GO:2000678)3.63610989
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.53525755
50protein complex disassembly (GO:0043241)3.51988438
51protein targeting to membrane (GO:0006612)3.50511499
52L-methionine salvage (GO:0071267)3.48339609
53L-methionine biosynthetic process (GO:0071265)3.48339609
54amino acid salvage (GO:0043102)3.48339609
55nucleotide transmembrane transport (GO:1901679)3.47607851
56cellular response to interferon-beta (GO:0035458)3.42696638
57serotonin receptor signaling pathway (GO:0007210)3.41894560
58macromolecular complex disassembly (GO:0032984)3.37319173
59mitochondrial respiratory chain complex assembly (GO:0033108)3.31619709
60nuclear-transcribed mRNA catabolic process (GO:0000956)3.27700212
61male meiosis (GO:0007140)3.26435773
62GTP biosynthetic process (GO:0006183)3.23797027
63establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.20637103
64mitochondrion transport along microtubule (GO:0047497)3.20637103
65cytidine metabolic process (GO:0046087)3.20163788
66cytidine catabolic process (GO:0006216)3.20163788
67cytidine deamination (GO:0009972)3.20163788
68positive regulation of interleukin-8 secretion (GO:2000484)3.18994292
69regulation of cGMP metabolic process (GO:0030823)3.14200961
70negative regulation by host of viral transcription (GO:0043922)3.14014036
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13178131
72maturation of 5.8S rRNA (GO:0000460)3.09368742
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09083466
74L-fucose catabolic process (GO:0042355)3.08554381
75fucose catabolic process (GO:0019317)3.08554381
76L-fucose metabolic process (GO:0042354)3.08554381
77termination of RNA polymerase III transcription (GO:0006386)3.06802332
78transcription elongation from RNA polymerase III promoter (GO:0006385)3.06802332
79membrane budding (GO:0006900)3.06507566
80negative regulation of catecholamine secretion (GO:0033604)3.04413718
81mRNA catabolic process (GO:0006402)3.03583974
82positive regulation of respiratory burst (GO:0060267)3.01941213
83negative regulation of T cell differentiation in thymus (GO:0033085)2.97943438
84rRNA modification (GO:0000154)2.94074057
85response to interferon-beta (GO:0035456)2.88565146
86pyrimidine-containing compound transmembrane transport (GO:0072531)2.86927418
87platelet dense granule organization (GO:0060155)2.85688653
88regulation of regulatory T cell differentiation (GO:0045589)2.82582508
89adrenergic receptor signaling pathway (GO:0071875)2.80381485
90UTP biosynthetic process (GO:0006228)2.78452070
91RNA catabolic process (GO:0006401)2.76803585
92DNA ligation (GO:0006266)2.76030581
93respiratory chain complex IV assembly (GO:0008535)2.74784617
94hydrogen ion transmembrane transport (GO:1902600)2.74673439
95establishment of mitochondrion localization (GO:0051654)2.69944160
96N-acetylglucosamine metabolic process (GO:0006044)2.68004470
97behavioral response to nicotine (GO:0035095)2.67212260
98* signal peptide processing (GO:0006465)2.65658315
99regulation of interleukin-12 biosynthetic process (GO:0045075)2.62939845
100detection of light stimulus involved in sensory perception (GO:0050962)2.61781033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.79529538
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.41560970
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.17117240
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.06796212
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.79926998
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11040426
7ZNF274_21170338_ChIP-Seq_K562_Hela3.08964841
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99912941
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.77041459
10VDR_22108803_ChIP-Seq_LS180_Human2.73113720
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61716231
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39030717
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.31467438
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22064268
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20332052
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10756669
17MYC_18940864_ChIP-ChIP_HL60_Human2.07869606
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07327804
19VDR_23849224_ChIP-Seq_CD4+_Human1.88434087
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.85616898
21FOXP3_21729870_ChIP-Seq_TREG_Human1.79320756
22ELK1_19687146_ChIP-ChIP_HELA_Human1.77166450
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.76366213
24FUS_26573619_Chip-Seq_HEK293_Human1.74197882
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71695967
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70052207
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65740032
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63334741
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61429120
30P300_19829295_ChIP-Seq_ESCs_Human1.60545935
31NANOG_19829295_ChIP-Seq_ESCs_Human1.60075543
32SOX2_19829295_ChIP-Seq_ESCs_Human1.60075543
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.57631677
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50158711
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47271799
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46726176
37EWS_26573619_Chip-Seq_HEK293_Human1.43211626
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41245147
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36555136
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36503699
41TP53_22573176_ChIP-Seq_HFKS_Human1.36228924
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.34003278
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33148201
44FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32106876
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29208474
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29012026
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.29012026
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28569424
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28344408
50PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.28044864
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26594118
52AR_20517297_ChIP-Seq_VCAP_Human1.25586660
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.25438140
54TTF2_22483619_ChIP-Seq_HELA_Human1.22701046
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22470757
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20706124
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.20507926
58RNF2_27304074_Chip-Seq_NSC_Mouse1.20463654
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19457995
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16738095
61ER_23166858_ChIP-Seq_MCF-7_Human1.15950901
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15608281
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13579370
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10047054
65FOXH1_21741376_ChIP-Seq_EPCs_Human1.07974182
66TCF4_22108803_ChIP-Seq_LS180_Human1.06493544
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05421904
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05219012
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05133430
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.04157887
71TAF15_26573619_Chip-Seq_HEK293_Human1.03672550
72BCAT_22108803_ChIP-Seq_LS180_Human1.01707193
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01520397
74PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99193855
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98851966
76CRX_20693478_ChIP-Seq_RETINA_Mouse0.95557319
77THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94716609
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94190536
79SOX2_16153702_ChIP-ChIP_HESCs_Human0.91441136
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90513317
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89758380
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86996688
83AR_21572438_ChIP-Seq_LNCaP_Human0.86916662
84CDX2_22108803_ChIP-Seq_LS180_Human0.86589316
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86218528
86E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85671721
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85231580
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85188521
89YY1_21170310_ChIP-Seq_MESCs_Mouse0.84710549
90IRF1_19129219_ChIP-ChIP_H3396_Human0.84220391
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83452474
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.83189322
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81183352
94ERA_21632823_ChIP-Seq_H3396_Human0.80981956
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80890267
96MYC_19030024_ChIP-ChIP_MESCs_Mouse0.80867282
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.80737647
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.80317914
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.79605322
100P300_18555785_Chip-Seq_ESCs_Mouse0.77001122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation9.83727838
2MP0006292_abnormal_olfactory_placode5.03104353
3MP0004147_increased_porphyrin_level3.28414706
4MP0003646_muscle_fatigue2.73037009
5MP0005397_hematopoietic_system_phenotyp2.29904778
6MP0001545_abnormal_hematopoietic_system2.29904778
7MP0002277_abnormal_respiratory_mucosa2.25663942
8MP0008058_abnormal_DNA_repair2.16294625
9MP0002638_abnormal_pupillary_reflex2.13446527
10MP0008789_abnormal_olfactory_epithelium2.11883352
11MP0000569_abnormal_digit_pigmentation2.11162428
12MP0001873_stomach_inflammation1.95478095
13MP0004145_abnormal_muscle_electrophysio1.92579403
14MP0006072_abnormal_retinal_apoptosis1.91685451
15MP0005174_abnormal_tail_pigmentation1.89939457
16MP0005551_abnormal_eye_electrophysiolog1.73811027
17MP0009697_abnormal_copulation1.73705645
18MP0005671_abnormal_response_to1.70671861
19MP0004142_abnormal_muscle_tone1.65747507
20MP0005360_urolithiasis1.63321683
21MP0005085_abnormal_gallbladder_physiolo1.57253778
22MP0003938_abnormal_ear_development1.57237236
23MP0000566_synostosis1.52049227
24MP0002938_white_spotting1.51962337
25MP0002837_dystrophic_cardiac_calcinosis1.48087020
26MP0005394_taste/olfaction_phenotype1.47943255
27MP0005499_abnormal_olfactory_system1.47943255
28MP0001529_abnormal_vocalization1.41468193
29MP0008995_early_reproductive_senescence1.35068646
30MP0002139_abnormal_hepatobiliary_system1.34247874
31MP0002095_abnormal_skin_pigmentation1.26065647
32MP0005381_digestive/alimentary_phenotyp1.24365339
33MP0010386_abnormal_urinary_bladder1.22304519
34MP0000462_abnormal_digestive_system1.19013178
35MP0005167_abnormal_blood-brain_barrier1.18976373
36MP0003890_abnormal_embryonic-extraembry1.17147056
37MP0001663_abnormal_digestive_system1.17016358
38MP0001346_abnormal_lacrimal_gland1.15094467
39MP0004885_abnormal_endolymph1.12328027
40MP0002234_abnormal_pharynx_morphology1.11106499
41MP0008775_abnormal_heart_ventricle1.10516708
42MP0003567_abnormal_fetal_cardiomyocyte1.08539064
43MP0003011_delayed_dark_adaptation1.07229010
44MP0002736_abnormal_nociception_after1.07169013
45MP0009785_altered_susceptibility_to1.06111435
46MP0003195_calcinosis1.04964158
47MP0003718_maternal_effect1.03636725
48MP0003186_abnormal_redox_activity1.00031106
49MP0005387_immune_system_phenotype0.98620188
50MP0001790_abnormal_immune_system0.98620188
51MP0001853_heart_inflammation0.98337820
52MP0008872_abnormal_physiological_respon0.96019819
53MP0003693_abnormal_embryo_hatching0.95877794
54MP0000538_abnormal_urinary_bladder0.94077931
55MP0003119_abnormal_digestive_system0.93243020
56MP0002138_abnormal_hepatobiliary_system0.93053366
57MP0001919_abnormal_reproductive_system0.91718565
58MP0002735_abnormal_chemical_nociception0.89871754
59MP0006276_abnormal_autonomic_nervous0.89246837
60MP0005636_abnormal_mineral_homeostasis0.89154883
61MP0003880_abnormal_central_pattern0.87709208
62MP0008004_abnormal_stomach_pH0.87405849
63MP0008877_abnormal_DNA_methylation0.85675921
64MP0005645_abnormal_hypothalamus_physiol0.84386116
65MP0004782_abnormal_surfactant_physiolog0.83506090
66MP0006054_spinal_hemorrhage0.81417579
67MP0001968_abnormal_touch/_nociception0.80109011
68MP0002933_joint_inflammation0.79187279
69MP0000631_abnormal_neuroendocrine_gland0.78918572
70MP0003878_abnormal_ear_physiology0.76266314
71MP0005377_hearing/vestibular/ear_phenot0.76266314
72MP0002233_abnormal_nose_morphology0.75873010
73MP0004957_abnormal_blastocyst_morpholog0.74817987
74MP0005410_abnormal_fertilization0.74551910
75MP0004883_abnormal_blood_vessel0.73403049
76MP0009046_muscle_twitch0.72997132
77MP0002282_abnormal_trachea_morphology0.72893804
78MP0003303_peritoneal_inflammation0.72598969
79MP0001293_anophthalmia0.72395826
80MP0003638_abnormal_response/metabolism_0.71619006
81MP0001286_abnormal_eye_development0.71477571
82MP0003252_abnormal_bile_duct0.70967101
83MP0001800_abnormal_humoral_immune0.69251024
84MP0004084_abnormal_cardiac_muscle0.68588560
85MP0004742_abnormal_vestibular_system0.68316831
86MP0000470_abnormal_stomach_morphology0.66707073
87MP0005389_reproductive_system_phenotype0.66309186
88MP0005084_abnormal_gallbladder_morpholo0.65733500
89MP0000534_abnormal_ureter_morphology0.63756128
90MP0005253_abnormal_eye_physiology0.63349092
91MP0005075_abnormal_melanosome_morpholog0.62846902
92MP0005195_abnormal_posterior_eye0.62648153
93MP0001986_abnormal_taste_sensitivity0.61264839
94MP0003283_abnormal_digestive_organ0.58868872
95MP0002148_abnormal_hypersensitivity_rea0.58365076
96MP0002272_abnormal_nervous_system0.57818328
97MP0004133_heterotaxia0.57766273
98MP0001485_abnormal_pinna_reflex0.57748291
99MP0005365_abnormal_bile_salt0.56210058
100MP0001905_abnormal_dopamine_level0.53590632

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)6.35821516
2Decreased central vision (HP:0007663)5.02379989
3Pendular nystagmus (HP:0012043)4.87041801
4Septo-optic dysplasia (HP:0100842)4.57136082
5Abnormal rod and cone electroretinograms (HP:0008323)4.33548244
6Increased hepatocellular lipid droplets (HP:0006565)4.32220702
7Disinhibition (HP:0000734)4.25615154
8Acute necrotizing encephalopathy (HP:0006965)4.20233249
9Acanthocytosis (HP:0001927)4.06824663
10Lipid accumulation in hepatocytes (HP:0006561)3.89627699
11Abnormal mitochondria in muscle tissue (HP:0008316)3.54406932
12Mitochondrial inheritance (HP:0001427)3.43941443
13Progressive macrocephaly (HP:0004481)3.41896988
14Acute encephalopathy (HP:0006846)3.40124662
15Reticulocytopenia (HP:0001896)3.33572166
16Absent septum pellucidum (HP:0001331)3.16796275
17Renal Fanconi syndrome (HP:0001994)3.10800183
18Keratoconus (HP:0000563)3.07708020
19Increased corneal curvature (HP:0100692)3.07708020
20Aplastic anemia (HP:0001915)3.06261277
21Increased CSF lactate (HP:0002490)3.05692062
22Personality changes (HP:0000751)3.01972359
23Inappropriate behavior (HP:0000719)3.01685967
24Optic disc pallor (HP:0000543)2.98085787
25Exertional dyspnea (HP:0002875)2.91628664
26IgM deficiency (HP:0002850)2.86499383
27Attenuation of retinal blood vessels (HP:0007843)2.85717088
28Oral leukoplakia (HP:0002745)2.78062950
293-Methylglutaconic aciduria (HP:0003535)2.75620540
30Type II lissencephaly (HP:0007260)2.67568264
31Maternal diabetes (HP:0009800)2.66154390
32Glycosuria (HP:0003076)2.63425302
33Abnormality of urine glucose concentration (HP:0011016)2.63425302
34Pallor (HP:0000980)2.59219134
35Macrocytic anemia (HP:0001972)2.58721695
36Congenital, generalized hypertrichosis (HP:0004540)2.57285166
37Optic nerve hypoplasia (HP:0000609)2.55993845
38Partial duplication of thumb phalanx (HP:0009944)2.52868023
39Increased intramyocellular lipid droplets (HP:0012240)2.52451013
40Delayed CNS myelination (HP:0002188)2.52006018
41Dyskinesia (HP:0100660)2.50136579
42Hypothermia (HP:0002045)2.49556153
43Carpal bone hypoplasia (HP:0001498)2.48318737
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48105100
45Hyperphosphaturia (HP:0003109)2.46837204
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.46273708
47Abnormality of the septum pellucidum (HP:0007375)2.40704961
48Cerebral edema (HP:0002181)2.40047667
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37149650
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37149650
51Hepatocellular necrosis (HP:0001404)2.33590901
52Methylmalonic aciduria (HP:0012120)2.31074226
53Cerebral hypomyelination (HP:0006808)2.27290560
54Congenital stationary night blindness (HP:0007642)2.24521382
55Colon cancer (HP:0003003)2.18971330
56Self-mutilation (HP:0000742)2.18964445
57Retinal dysplasia (HP:0007973)2.18710101
58CNS hypomyelination (HP:0003429)2.18645995
59Constricted visual fields (HP:0001133)2.17123098
60Respiratory difficulties (HP:0002880)2.16407456
61Agitation (HP:0000713)2.16360417
62Type 2 muscle fiber atrophy (HP:0003554)2.14477605
63Partial duplication of the phalanx of hand (HP:0009999)2.12800169
64Oligomenorrhea (HP:0000876)2.11967709
65Abnormal number of erythroid precursors (HP:0012131)2.11187415
66Acute hepatic failure (HP:0006554)2.07704826
67Calf muscle hypertrophy (HP:0008981)2.07572780
68Abnormality of renal resorption (HP:0011038)2.07445318
69Hepatic necrosis (HP:0002605)2.06195511
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02959015
71Nephronophthisis (HP:0000090)2.02921223
72Increased muscle lipid content (HP:0009058)2.01421381
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01227900
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.01227900
75Abnormal albumin level (HP:0012116)2.00224784
76Hypoalbuminemia (HP:0003073)2.00224784
77Infantile muscular hypotonia (HP:0008947)1.96831418
78Macular degeneration (HP:0000608)1.96343654
79Abnormality of cells of the erythroid lineage (HP:0012130)1.93565666
80Choreoathetosis (HP:0001266)1.93329538
81Irregular epiphyses (HP:0010582)1.92222847
82Abnormality of the renal medulla (HP:0100957)1.89549228
83Medial flaring of the eyebrow (HP:0010747)1.89278510
84Vasculitis (HP:0002633)1.87434856
85Abnormality of the labia minora (HP:0012880)1.86180228
86Lethargy (HP:0001254)1.85038046
87Stenosis of the external auditory canal (HP:0000402)1.82712498
88Muscle hypertrophy of the lower extremities (HP:0008968)1.82482481
89T lymphocytopenia (HP:0005403)1.82062894
90Recurrent sinusitis (HP:0011108)1.81632631
91Azoospermia (HP:0000027)1.80603028
92Generalized aminoaciduria (HP:0002909)1.79927571
93Decreased muscle mass (HP:0003199)1.79796459
94Muscle fiber atrophy (HP:0100295)1.79782075
95Myokymia (HP:0002411)1.78913254
96Chronic diarrhea (HP:0002028)1.77875452
97Lactic acidosis (HP:0003128)1.77219303
98Methylmalonic acidemia (HP:0002912)1.76149626
99IgG deficiency (HP:0004315)1.73846695
100Psychosis (HP:0000709)1.73603710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.23102225
2NME23.58030059
3TXK3.10212086
4TIE12.61226790
5BCKDK2.61208703
6BMPR1B2.57566305
7VRK22.52231525
8WNK32.37718891
9TNIK2.29845320
10RIPK42.23075262
11MAP4K22.11701543
12GRK12.07655498
13PASK2.04006428
14MST42.00990741
15TEC1.80697663
16ACVR1B1.78295912
17NUAK11.70966257
18WNK41.66300516
19MAP4K11.65176480
20FGFR21.62494252
21STK161.59763978
22ZAK1.57497372
23EIF2AK31.53641473
24KDR1.48821623
25OXSR11.46187789
26VRK11.43287092
27TAF11.41652411
28BMPR21.32871514
29TLK11.31494657
30FES1.30823093
31INSRR1.28112163
32BCR1.27397792
33MATK1.27370049
34PRKG21.26110875
35ITK1.25496407
36PINK11.17469702
37TYRO31.15010508
38TGFBR11.12147953
39GRK61.01370260
40MAP3K40.94921417
41PRKCQ0.91232527
42DYRK20.88031585
43SYK0.85934408
44NME10.83662232
45ADRBK20.83419802
46MAP2K60.83021423
47STK390.79676083
48FRK0.77864743
49PLK30.75849833
50MELK0.75318245
51BRSK20.74000059
52MYLK0.70029396
53KIT0.69679960
54STK30.69315014
55PRKCG0.68381984
56BTK0.67808832
57PHKG10.62850677
58PHKG20.62850677
59OBSCN0.62120383
60FGFR10.61072877
61ADRBK10.58347104
62CSK0.58220820
63CSNK1A10.56398900
64TAOK10.54620627
65CDC70.54566190
66EGFR0.53557182
67DAPK30.53345340
68CSNK2A20.53232598
69MAP3K120.53101493
70PLK40.52971686
71CSNK2A10.52487667
72NEK10.52322915
73GRK70.51939071
74IGF1R0.50969489
75TRIM280.49087440
76IKBKB0.48851157
77PRKACA0.48639968
78STK110.48042026
79LCK0.47562825
80PIK3CA0.47346935
81DAPK10.45611999
82PRKG10.45360251
83PRKCE0.42510544
84PRKCA0.40613345
85RPS6KA50.39856661
86CSNK1G20.39125544
87CAMK2A0.38717608
88NEK20.37481744
89PIM10.35857928
90CSNK1G30.35394948
91LYN0.32765378
92MKNK10.32564073
93PRKCB0.31669173
94WEE10.31266150
95DAPK20.31252520
96PIM20.30967013
97PRKACG0.30726594
98MUSK0.30142336
99GRK50.29152469
100PIK3CG0.28038745

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.46547168
2Oxidative phosphorylation_Homo sapiens_hsa001904.09798620
3Protein export_Homo sapiens_hsa030603.55231777
4Parkinsons disease_Homo sapiens_hsa050123.35244301
5Proteasome_Homo sapiens_hsa030503.10109518
6RNA polymerase_Homo sapiens_hsa030202.78090089
7Alzheimers disease_Homo sapiens_hsa050102.31664607
8Huntingtons disease_Homo sapiens_hsa050162.31021159
9Autoimmune thyroid disease_Homo sapiens_hsa053202.11780031
10Cardiac muscle contraction_Homo sapiens_hsa042602.05680828
11Asthma_Homo sapiens_hsa053102.01978677
12Graft-versus-host disease_Homo sapiens_hsa053322.01839386
13Primary immunodeficiency_Homo sapiens_hsa053401.98466303
14Allograft rejection_Homo sapiens_hsa053301.97982621
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96823739
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93210449
17Type I diabetes mellitus_Homo sapiens_hsa049401.78654004
18Homologous recombination_Homo sapiens_hsa034401.60924460
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.54590223
20RNA degradation_Homo sapiens_hsa030181.50348839
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45112089
22Taste transduction_Homo sapiens_hsa047421.40287332
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39099848
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38960984
25Antigen processing and presentation_Homo sapiens_hsa046121.36475753
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32317876
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28867669
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28415667
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23221013
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.17800338
31Rheumatoid arthritis_Homo sapiens_hsa053231.15934135
32Mismatch repair_Homo sapiens_hsa034301.15853820
33Basal transcription factors_Homo sapiens_hsa030221.11290893
34Retinol metabolism_Homo sapiens_hsa008301.10680390
35Fanconi anemia pathway_Homo sapiens_hsa034601.08462821
36Sulfur metabolism_Homo sapiens_hsa009201.03093431
37One carbon pool by folate_Homo sapiens_hsa006701.01940718
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99048104
39Tryptophan metabolism_Homo sapiens_hsa003800.98384663
40Maturity onset diabetes of the young_Homo sapiens_hsa049500.96647126
41Insulin secretion_Homo sapiens_hsa049110.94251433
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93498076
43Nucleotide excision repair_Homo sapiens_hsa034200.93377279
44Selenocompound metabolism_Homo sapiens_hsa004500.92000540
45beta-Alanine metabolism_Homo sapiens_hsa004100.91787847
46Purine metabolism_Homo sapiens_hsa002300.89797968
47Olfactory transduction_Homo sapiens_hsa047400.88373147
48Pyrimidine metabolism_Homo sapiens_hsa002400.87229649
49Hematopoietic cell lineage_Homo sapiens_hsa046400.85518208
50DNA replication_Homo sapiens_hsa030300.82871116
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79070254
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79036793
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78353919
54Histidine metabolism_Homo sapiens_hsa003400.77760264
55Phototransduction_Homo sapiens_hsa047440.74721527
56Nitrogen metabolism_Homo sapiens_hsa009100.73487726
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69444758
58Folate biosynthesis_Homo sapiens_hsa007900.66536080
59Serotonergic synapse_Homo sapiens_hsa047260.65504030
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65205594
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64741440
62RNA transport_Homo sapiens_hsa030130.63129068
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61601614
64Metabolic pathways_Homo sapiens_hsa011000.61005367
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59567467
66ABC transporters_Homo sapiens_hsa020100.59310730
67Sulfur relay system_Homo sapiens_hsa041220.59271781
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56851229
69Chemical carcinogenesis_Homo sapiens_hsa052040.56797959
70Staphylococcus aureus infection_Homo sapiens_hsa051500.54039838
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53416540
72Linoleic acid metabolism_Homo sapiens_hsa005910.53350480
73African trypanosomiasis_Homo sapiens_hsa051430.53170804
74Pancreatic secretion_Homo sapiens_hsa049720.52637166
75Propanoate metabolism_Homo sapiens_hsa006400.52177684
76Vitamin digestion and absorption_Homo sapiens_hsa049770.50915123
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48660536
78Morphine addiction_Homo sapiens_hsa050320.46960581
79Butanoate metabolism_Homo sapiens_hsa006500.46942892
80mRNA surveillance pathway_Homo sapiens_hsa030150.46177894
81Nicotine addiction_Homo sapiens_hsa050330.45712555
82Glycerolipid metabolism_Homo sapiens_hsa005610.44646297
83Mineral absorption_Homo sapiens_hsa049780.41987941
84Salivary secretion_Homo sapiens_hsa049700.41628720
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41060684
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38514801
87Systemic lupus erythematosus_Homo sapiens_hsa053220.38431179
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.37198917
89Peroxisome_Homo sapiens_hsa041460.37180096
90Spliceosome_Homo sapiens_hsa030400.36710414
91Arachidonic acid metabolism_Homo sapiens_hsa005900.35223352
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35043163
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34312557
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32230172
95Protein digestion and absorption_Homo sapiens_hsa049740.32059841
96Regulation of autophagy_Homo sapiens_hsa041400.29338736
97Collecting duct acid secretion_Homo sapiens_hsa049660.28804357
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.28224677
99GABAergic synapse_Homo sapiens_hsa047270.27203020
100Renin-angiotensin system_Homo sapiens_hsa046140.25156027

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