SEC11C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.54174324
2axon ensheathment in central nervous system (GO:0032291)5.54174324
3* signal peptide processing (GO:0006465)5.44680749
4cellular ketone body metabolic process (GO:0046950)4.72758173
5ketone body metabolic process (GO:1902224)4.40812308
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.31243721
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.31243721
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.26898484
9water-soluble vitamin biosynthetic process (GO:0042364)4.15963235
10neutrophil activation involved in immune response (GO:0002283)4.13562778
11regulation of glucokinase activity (GO:0033131)4.12647026
12regulation of hexokinase activity (GO:1903299)4.12647026
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.11971439
14antigen processing and presentation of endogenous antigen (GO:0019883)4.03021700
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.97357698
16mast cell activation (GO:0045576)3.97256911
17respiratory chain complex IV assembly (GO:0008535)3.96051765
18protein complex biogenesis (GO:0070271)3.88034992
19amyloid precursor protein metabolic process (GO:0042982)3.75191857
20respiratory electron transport chain (GO:0022904)3.63802031
21electron transport chain (GO:0022900)3.61624528
22cytochrome complex assembly (GO:0017004)3.59624108
23endocrine pancreas development (GO:0031018)3.59150924
24GPI anchor biosynthetic process (GO:0006506)3.58031467
25COPI coating of Golgi vesicle (GO:0048205)3.55451080
26Golgi transport vesicle coating (GO:0048200)3.55451080
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50580882
28ATP synthesis coupled proton transport (GO:0015986)3.50580882
29mitochondrial respiratory chain complex assembly (GO:0033108)3.49740538
30* cotranslational protein targeting to membrane (GO:0006613)3.47156713
31mannosylation (GO:0097502)3.45005341
32* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44399762
33* protein targeting to ER (GO:0045047)3.42527210
34nucleotide transmembrane transport (GO:1901679)3.39505418
35GDP-mannose metabolic process (GO:0019673)3.39046934
36amyloid precursor protein catabolic process (GO:0042987)3.38438990
37protein maturation by protein folding (GO:0022417)3.38113045
38sequestering of metal ion (GO:0051238)3.35756816
39* protein localization to endoplasmic reticulum (GO:0070972)3.35700060
40* establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30921439
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.28779934
42respiratory burst (GO:0045730)3.28529039
43platelet dense granule organization (GO:0060155)3.18827843
44regulation of mitochondrial translation (GO:0070129)3.17848453
45mast cell degranulation (GO:0043303)3.16375825
46mast cell activation involved in immune response (GO:0002279)3.16375825
47leukocyte degranulation (GO:0043299)3.14922653
48positive regulation of respiratory burst (GO:0060267)3.11331862
49GPI anchor metabolic process (GO:0006505)3.09452423
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.07203920
51L-phenylalanine catabolic process (GO:0006559)3.07203920
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05762985
53positive regulation of B cell differentiation (GO:0045579)3.05151239
54ribosomal small subunit assembly (GO:0000028)3.04579796
55fatty acid elongation (GO:0030497)3.01895477
56regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01787754
57ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.00743888
58lactate metabolic process (GO:0006089)3.00244706
59positive regulation of gamma-delta T cell activation (GO:0046645)3.00015389
60regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.97273157
61ER overload response (GO:0006983)2.94436018
62DNA deamination (GO:0045006)2.93278596
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89935383
64energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.88436975
65ATP hydrolysis coupled proton transport (GO:0015991)2.88436975
66cellular response to interferon-beta (GO:0035458)2.88164763
67inositol phosphate catabolic process (GO:0071545)2.88084890
68myelin maintenance (GO:0043217)2.87370913
69hydrogen ion transmembrane transport (GO:1902600)2.84863552
70magnesium ion transport (GO:0015693)2.84083812
71insulin secretion (GO:0030073)2.83764142
72positive regulation of peptide hormone secretion (GO:0090277)2.80832293
73positive regulation of insulin secretion (GO:0032024)2.80172623
74proton transport (GO:0015992)2.76343214
75anterograde synaptic vesicle transport (GO:0048490)2.76187258
76nitric oxide mediated signal transduction (GO:0007263)2.75872584
77exocrine pancreas development (GO:0031017)2.75744694
78creatine metabolic process (GO:0006600)2.75504651
79hydrogen transport (GO:0006818)2.74210111
80nucleobase catabolic process (GO:0046113)2.73559084
81positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.72726536
82positive regulation of peptide secretion (GO:0002793)2.71948838
83glycerophospholipid catabolic process (GO:0046475)2.71822650
84protein retention in ER lumen (GO:0006621)2.70256595
85neutrophil mediated immunity (GO:0002446)2.70069390
86B cell receptor signaling pathway (GO:0050853)2.70039883
87regulation of type B pancreatic cell apoptotic process (GO:2000674)2.69827119
88defense response to protozoan (GO:0042832)2.65940326
89response to interferon-beta (GO:0035456)2.65805967
90antigen processing and presentation via MHC class Ib (GO:0002475)2.65324222
91regulation of B cell differentiation (GO:0045577)2.65226848
92proteasome assembly (GO:0043248)2.65007673
93autophagic vacuole fusion (GO:0000046)2.63731416
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63654120
95L-phenylalanine metabolic process (GO:0006558)2.63654120
96preassembly of GPI anchor in ER membrane (GO:0016254)2.63609842
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.60792849
98protein neddylation (GO:0045116)2.60579021
99negative regulation of neurological system process (GO:0031645)2.60443474
100intracellular protein transmembrane import (GO:0044743)2.59899094
101C-terminal protein lipidation (GO:0006501)2.59830082
102inositol phosphate dephosphorylation (GO:0046855)2.59638014
103phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59638014
104neutrophil activation (GO:0042119)2.59285152
105dopamine transport (GO:0015872)2.58271302
106myeloid cell activation involved in immune response (GO:0002275)2.57335614
107positive regulation of oligodendrocyte differentiation (GO:0048714)2.55998578
108proline transport (GO:0015824)2.55470276
109fucose catabolic process (GO:0019317)2.53734691
110L-fucose metabolic process (GO:0042354)2.53734691
111L-fucose catabolic process (GO:0042355)2.53734691
112cullin deneddylation (GO:0010388)2.53542413
113pyrimidine nucleobase catabolic process (GO:0006208)2.52452854
114phenylpropanoid metabolic process (GO:0009698)2.51925091
115viral transcription (GO:0019083)2.51442875
116negative regulation of interleukin-17 production (GO:0032700)2.50131537
117aromatic amino acid family catabolic process (GO:0009074)2.49941215
118reflex (GO:0060004)2.49405436
119glycosphingolipid biosynthetic process (GO:0006688)2.49085027
120chaperone-mediated protein transport (GO:0072321)2.48866120
121C-terminal protein amino acid modification (GO:0018410)2.48809077
122phosphatidylserine acyl-chain remodeling (GO:0036150)2.48436695
123melanosome transport (GO:0032402)2.48037348
124leukocyte aggregation (GO:0070486)2.47157231
125protein localization to cilium (GO:0061512)2.47131736
126behavioral response to nicotine (GO:0035095)2.47022823
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46408998
128negative regulation of chemokine production (GO:0032682)2.45825722
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.45555096
130response to protozoan (GO:0001562)2.45494012
131alanine transport (GO:0032328)2.44506745
132regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43937151
133pigment granule transport (GO:0051904)2.43641752
134aldehyde catabolic process (GO:0046185)2.43016933
135positive regulation of glycolytic process (GO:0045821)2.42778367
136nucleotide transport (GO:0006862)2.42682506
137leukotriene biosynthetic process (GO:0019370)2.42652392
138translational termination (GO:0006415)2.42155033
139indolalkylamine metabolic process (GO:0006586)2.41693134
140peptidyl-histidine modification (GO:0018202)2.40999789
141detection of calcium ion (GO:0005513)2.40877464
142pteridine-containing compound biosynthetic process (GO:0042559)2.39974677
143positive regulation of TOR signaling (GO:0032008)2.39801005
144establishment of melanosome localization (GO:0032401)2.39740638
145* regulation of insulin secretion (GO:0050796)2.39562624
146regulation of B cell receptor signaling pathway (GO:0050855)2.39337740
147protein N-linked glycosylation via asparagine (GO:0018279)2.39328458
148glandular epithelial cell differentiation (GO:0002067)2.39120233
149* protein targeting to membrane (GO:0006612)2.38813119
150antibacterial humoral response (GO:0019731)2.36916262
151regulated secretory pathway (GO:0045055)2.36399772
152anterograde axon cargo transport (GO:0008089)2.36203963
153negative regulation of glycoprotein biosynthetic process (GO:0010561)2.35979365
154establishment of pigment granule localization (GO:0051905)2.35896882
155negative regulation of acute inflammatory response (GO:0002674)2.35755380
156mucosal immune response (GO:0002385)2.35677713
157regulation of cellular amino acid metabolic process (GO:0006521)2.35352747
158neuron fate specification (GO:0048665)2.35191573
159cellular response to type I interferon (GO:0071357)2.35004716
160type I interferon signaling pathway (GO:0060337)2.35004716
161polyol catabolic process (GO:0046174)2.34835610
162fucose metabolic process (GO:0006004)2.34281008
163regulation of T cell migration (GO:2000404)2.34099796
164negative regulation of membrane potential (GO:0045837)2.33886052
165response to type I interferon (GO:0034340)2.32709915
166peptidyl-asparagine modification (GO:0018196)2.32178103
167regulation of neurotransmitter uptake (GO:0051580)2.31313285
168negative regulation of protein oligomerization (GO:0032460)2.31088771
169regulation of protein glycosylation (GO:0060049)2.31037024
170granulocyte activation (GO:0036230)2.30471202
171phosphatidylinositol acyl-chain remodeling (GO:0036149)2.30087502
172nonmotile primary cilium assembly (GO:0035058)2.29783436
173leukocyte migration involved in inflammatory response (GO:0002523)2.29673316
174regulation of T cell receptor signaling pathway (GO:0050856)2.29625479
175adaptation of signaling pathway (GO:0023058)2.29047003
176peptide hormone processing (GO:0016486)2.28195200
177protein N-linked glycosylation (GO:0006487)2.28101862
178positive regulation of cellular amine metabolic process (GO:0033240)2.27792794
179antimicrobial humoral response (GO:0019730)2.27149211
180nucleoside diphosphate catabolic process (GO:0009134)2.27107500
181transferrin transport (GO:0033572)2.26085144
182long-chain fatty acid biosynthetic process (GO:0042759)2.25487387
183organ or tissue specific immune response (GO:0002251)2.25332227
184myeloid leukocyte mediated immunity (GO:0002444)2.23859557
185mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.23742415
186mitochondrial respiratory chain complex I assembly (GO:0032981)2.23742415
187NADH dehydrogenase complex assembly (GO:0010257)2.23742415
188digestion (GO:0007586)2.21899789

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.83486097
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.18929463
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.91008426
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.84166754
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35595388
6* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27364694
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.22330725
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18509922
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16202125
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.08176629
11* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.69342398
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.63713108
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58789752
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55684665
15ZNF274_21170338_ChIP-Seq_K562_Hela2.47429887
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42230242
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.40190695
18SCL_19346495_ChIP-Seq_HPC-7_Human2.40186519
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.39051404
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.36627351
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.36605062
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.27743799
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.27158305
24GATA1_22025678_ChIP-Seq_K562_Human2.25851144
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24446663
26GBX2_23144817_ChIP-Seq_PC3_Human2.23938476
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.23475288
28SPI1_23547873_ChIP-Seq_NB4_Human2.22669845
29* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21591394
30IGF1R_20145208_ChIP-Seq_DFB_Human2.21284508
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.14732593
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11921191
33* ERG_20887958_ChIP-Seq_HPC-7_Mouse2.11434372
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07886797
35TAF15_26573619_Chip-Seq_HEK293_Human2.06043882
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05855234
37* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.05487674
38CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02693986
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02670722
40* MYB_26560356_Chip-Seq_TH2_Human1.97578904
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97352903
42RUNX_20019798_ChIP-Seq_JUKART_Human1.94790271
43VDR_22108803_ChIP-Seq_LS180_Human1.90835148
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89329748
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86694033
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85362802
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82078770
48* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.81227953
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.80794950
50FUS_26573619_Chip-Seq_HEK293_Human1.79598994
51VDR_23849224_ChIP-Seq_CD4+_Human1.77377122
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76289267
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.76185323
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74931776
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74751144
56* P300_19829295_ChIP-Seq_ESCs_Human1.74235134
57VDR_24763502_ChIP-Seq_THP-1_Human1.69397419
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.68328113
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66334410
60* RUNX1_22412390_ChIP-Seq_EML_Mouse1.64293858
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61867304
62VDR_21846776_ChIP-Seq_THP-1_Human1.61375584
63REST_21632747_ChIP-Seq_MESCs_Mouse1.58524295
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.57858702
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56865721
66* TP53_22573176_ChIP-Seq_HFKS_Human1.55734518
67HTT_18923047_ChIP-ChIP_STHdh_Human1.54368785
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.52650030
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51099664
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50802551
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49070816
72* ETS1_20019798_ChIP-Seq_JURKAT_Human1.48951756
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48349501
74* MYB_26560356_Chip-Seq_TH1_Human1.47404455
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46945123
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46842131
77EWS_26573619_Chip-Seq_HEK293_Human1.45792926
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44446949
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.44070714
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.43413077
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.41681856
82* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41344637
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40198554
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39625231
85GATA3_26560356_Chip-Seq_TH2_Human1.38667224
86GATA3_27048872_Chip-Seq_THYMUS_Human1.37782596
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36748050
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.36344370
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36259286
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.35944073
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35743619
92* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34959246
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.33607097
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33146261
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33031929
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32833085
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31778563
98MAF_26560356_Chip-Seq_TH1_Human1.30795305
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29981930
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28810129
101PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.28545059
102P53_22387025_ChIP-Seq_ESCs_Mouse1.28196390
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28122765
104ER_23166858_ChIP-Seq_MCF-7_Human1.28046101
105MYC_18940864_ChIP-ChIP_HL60_Human1.25408052
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.25284021
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25277819
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25212235
109CBP_20019798_ChIP-Seq_JUKART_Human1.25212235
110SMAD4_21799915_ChIP-Seq_A2780_Human1.24178320
111AR_25329375_ChIP-Seq_VCAP_Human1.22866098
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22764518
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.22747399
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22462644
115* SOX2_19829295_ChIP-Seq_ESCs_Human1.22438004
116* NANOG_19829295_ChIP-Seq_ESCs_Human1.22438004
117PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22415147
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22319035
119FOXP3_21729870_ChIP-Seq_TREG_Human1.22121140
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22097256
121BCAT_22108803_ChIP-Seq_LS180_Human1.21932731
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20333798
123FOXA1_25329375_ChIP-Seq_VCAP_Human1.20333798
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20026884
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.19456530
126SOX2_18555785_Chip-Seq_ESCs_Mouse1.19342952
127P300_18555785_Chip-Seq_ESCs_Mouse1.18286104
128PU_27001747_Chip-Seq_BMDM_Mouse1.18229983
129SPI1_23127762_ChIP-Seq_K562_Human1.17925348
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17742508
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17289065
132HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15547060
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15318396
134CRX_20693478_ChIP-Seq_RETINA_Mouse1.14903705
135SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13664858
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13577467
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13423511
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12921935
139CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12672609
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12609344
141NCOR_22424771_ChIP-Seq_293T_Human1.12401777
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12180682
143TAL1_26923725_Chip-Seq_HPCs_Mouse1.11696798
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11580156
145PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10893278
146CTCF_18555785_Chip-Seq_ESCs_Mouse1.10642102
147ELK1_19687146_ChIP-ChIP_HELA_Human1.10522236
148NMYC_18555785_Chip-Seq_ESCs_Mouse1.09772181
149NOTCH1_21737748_ChIP-Seq_TLL_Human1.08645759
150TCF4_22108803_ChIP-Seq_LS180_Human1.08577500
151GATA1_19941827_ChIP-Seq_MEL_Mouse1.08232369
152STAT1_20625510_ChIP-Seq_HELA_Human1.08095143
153FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07877650
154EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07398470
155UTX_26944678_Chip-Seq_JUKART_Human1.07143383
156E2F1_18555785_Chip-Seq_ESCs_Mouse1.06954775
157OCT4_18555785_Chip-Seq_ESCs_Mouse1.06678670
158KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05570338
159ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05307970
160DCP1A_22483619_ChIP-Seq_HELA_Human1.05038407
161RNF2_27304074_Chip-Seq_NSC_Mouse1.04862755
162SMAD3_21741376_ChIP-Seq_EPCs_Human1.04099111
163FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03704459
164TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02595543
165ETS1_22383799_ChIP-Seq_G1ME_Mouse1.02295670
166CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01929471
167STAT3_23295773_ChIP-Seq_U87_Human1.01551661
168ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00447056
169RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00061871
170PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98809849
171CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96818748
172FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94227222
173VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93952374
174CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92433937
175MAF_26560356_Chip-Seq_TH2_Human0.91887943
176GABP_19822575_ChIP-Seq_HepG2_Human0.91557433
177* TFEB_21752829_ChIP-Seq_HELA_Human0.87647514
178CTCF_26484167_Chip-Seq_Bcells_Mouse0.83741069
179GATA1_19941826_ChIP-Seq_K562_Human0.83068207
180PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82249705
181CIITA_25753668_ChIP-Seq_RAJI_Human0.81864487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.64588672
2MP0005671_abnormal_response_to3.20818187
3MP0002909_abnormal_adrenal_gland3.16401658
4MP0000920_abnormal_myelination2.73501388
5MP0003787_abnormal_imprinting2.69287035
6MP0009785_altered_susceptibility_to2.59732105
7MP0005000_abnormal_immune_tolerance2.57195171
8MP0005058_abnormal_lysosome_morphology2.56772061
9MP0005645_abnormal_hypothalamus_physiol2.53533864
10MP0002148_abnormal_hypersensitivity_rea2.52033844
11MP0003183_abnormal_peptide_metabolism2.52030955
12MP0001790_abnormal_immune_system2.51229595
13MP0005387_immune_system_phenotype2.51229595
14MP0009046_muscle_twitch2.49699772
15MP0003122_maternal_imprinting2.49524308
16MP0000685_abnormal_immune_system2.48709379
17MP0002822_catalepsy2.40843746
18MP0005025_abnormal_response_to2.37680050
19MP0001800_abnormal_humoral_immune2.36699309
20MP0002837_dystrophic_cardiac_calcinosis2.35605488
21MP0002723_abnormal_immune_serum2.29135121
22MP0006072_abnormal_retinal_apoptosis2.25206016
23MP0001984_abnormal_olfaction2.24371698
24MP0002419_abnormal_innate_immunity2.20897285
25MP0001873_stomach_inflammation2.18769314
26MP0002420_abnormal_adaptive_immunity2.18642844
27MP0008877_abnormal_DNA_methylation2.17190315
28MP0002638_abnormal_pupillary_reflex2.16218528
29MP0002452_abnormal_antigen_presenting2.15239878
30MP0001819_abnormal_immune_cell2.14796522
31MP0002166_altered_tumor_susceptibility2.13445776
32MP0002163_abnormal_gland_morphology2.11211676
33MP0003724_increased_susceptibility_to2.07647804
34MP0006082_CNS_inflammation2.02098427
35MP0005310_abnormal_salivary_gland2.00491289
36MP0003436_decreased_susceptibility_to1.99736637
37MP0004270_analgesia1.89371636
38MP0003656_abnormal_erythrocyte_physiolo1.88568268
39MP0001666_abnormal_nutrient_absorption1.85433475
40MP0002102_abnormal_ear_morphology1.83754469
41MP0002272_abnormal_nervous_system1.83336358
42MP0003880_abnormal_central_pattern1.82786098
43MP0003866_abnormal_defecation1.80926944
44MP0004043_abnormal_pH_regulation1.79462847
45MP0003763_abnormal_thymus_physiology1.77227008
46MP0009745_abnormal_behavioral_response1.76305185
47MP0003172_abnormal_lysosome_physiology1.73110681
48MP0000465_gastrointestinal_hemorrhage1.72318962
49MP0005646_abnormal_pituitary_gland1.71697655
50MP0008260_abnormal_autophagy1.71547241
51MP0000716_abnormal_immune_system1.69817344
52MP0002693_abnormal_pancreas_physiology1.69216665
53MP0002139_abnormal_hepatobiliary_system1.67777836
54MP0005551_abnormal_eye_electrophysiolog1.67297536
55MP0002398_abnormal_bone_marrow1.67255578
56MP0001845_abnormal_inflammatory_respons1.61195408
57MP0005253_abnormal_eye_physiology1.60526699
58MP0003283_abnormal_digestive_organ1.60380544
59MP0010155_abnormal_intestine_physiology1.60208145
60MP0005464_abnormal_platelet_physiology1.56437903
61MP0006054_spinal_hemorrhage1.56177612
62MP0009333_abnormal_splenocyte_physiolog1.55908005
63MP0001986_abnormal_taste_sensitivity1.55340716
64MP0002064_seizures1.53312217
65MP0002006_tumorigenesis1.51377873
66MP0005075_abnormal_melanosome_morpholog1.49170358
67MP0002090_abnormal_vision1.49155133
68MP0003011_delayed_dark_adaptation1.46801311
69MP0003121_genomic_imprinting1.45056690
70MP0002405_respiratory_system_inflammati1.42971183
71MP0004885_abnormal_endolymph1.42109416
72MP0003303_peritoneal_inflammation1.42026156
73MP0005365_abnormal_bile_salt1.41413115
74MP0005332_abnormal_amino_acid1.39457634
75MP0002429_abnormal_blood_cell1.38403699
76MP0005220_abnormal_exocrine_pancreas1.37608073
77MP0000490_abnormal_crypts_of1.35632561
78MP0000689_abnormal_spleen_morphology1.35186552
79MP0002572_abnormal_emotion/affect_behav1.34509852
80MP0004947_skin_inflammation1.34102563
81MP0002557_abnormal_social/conspecific_i1.32556655
82MP0002396_abnormal_hematopoietic_system1.32269746
83MP0001501_abnormal_sleep_pattern1.29400291
84MP0005083_abnormal_biliary_tract1.28256260
85MP0003186_abnormal_redox_activity1.26810067
86MP0005085_abnormal_gallbladder_physiolo1.25596481
87MP0003868_abnormal_feces_composition1.25586701
88MP0002735_abnormal_chemical_nociception1.24751017
89MP0006276_abnormal_autonomic_nervous1.24729327
90MP0001968_abnormal_touch/_nociception1.23682114
91MP0004924_abnormal_behavior1.22753175
92MP0005386_behavior/neurological_phenoty1.22753175
93MP0001533_abnormal_skeleton_physiology1.22696182
94MP0002722_abnormal_immune_system1.22446722
95MP0003635_abnormal_synaptic_transmissio1.22024115
96MP0008469_abnormal_protein_level1.21547408
97MP0001486_abnormal_startle_reflex1.20901565
98MP0002938_white_spotting1.20810257
99MP0001663_abnormal_digestive_system1.20756348
100MP0002078_abnormal_glucose_homeostasis1.20356389
101MP0005174_abnormal_tail_pigmentation1.19740656
102MP0002734_abnormal_mechanical_nocicepti1.18460734
103MP0000631_abnormal_neuroendocrine_gland1.18266579
104MP0005409_darkened_coat_color1.17754128
105MP0003300_gastrointestinal_ulcer1.16812774
106MP0004147_increased_porphyrin_level1.15358049
107MP0001756_abnormal_urination1.15040532
108MP0005379_endocrine/exocrine_gland_phen1.14946637
109MP0002928_abnormal_bile_duct1.14193587
110MP0004019_abnormal_vitamin_homeostasis1.14034688
111MP0003136_yellow_coat_color1.13358184
112MP0001853_heart_inflammation1.13346203
113MP0008995_early_reproductive_senescence1.12672534
114MP0001905_abnormal_dopamine_level1.12609535
115MP0001970_abnormal_pain_threshold1.12346123
116MP0010329_abnormal_lipoprotein_level1.12184497
117MP0002933_joint_inflammation1.11597634
118MP0009780_abnormal_chondrocyte_physiolo1.11484188
119MP0001485_abnormal_pinna_reflex1.10739980
120MP0001188_hyperpigmentation1.09701927
121MP0002063_abnormal_learning/memory/cond1.08740185
122MP0004859_abnormal_synaptic_plasticity1.05048572
123MP0004381_abnormal_hair_follicle1.04866533
124MP0002736_abnormal_nociception_after1.04739094
125MP0003690_abnormal_glial_cell1.03620297
126MP0000015_abnormal_ear_pigmentation1.03106572
127MP0002067_abnormal_sensory_capabilities1.02890459
128MP0010234_abnormal_vibrissa_follicle1.02726438
129MP0003123_paternal_imprinting1.02170953
130MP0001529_abnormal_vocalization1.01817892
131MP0010386_abnormal_urinary_bladder1.00555208
132MP0004142_abnormal_muscle_tone1.00235884
133MP0002009_preneoplasia1.00025437
134MP0008872_abnormal_physiological_respon0.99671521
135MP0005381_digestive/alimentary_phenotyp0.99059445
136MP0008875_abnormal_xenobiotic_pharmacok0.99022800
137MP0002733_abnormal_thermal_nociception0.98851313
138MP0005408_hypopigmentation0.98831826
139MP0003195_calcinosis0.97545367
140MP0001664_abnormal_digestion0.96918806
141MP0000604_amyloidosis0.96796052
142MP0003252_abnormal_bile_duct0.96159009
143MP0001944_abnormal_pancreas_morphology0.96119976
144MP0001851_eye_inflammation0.96109784
145MP0001765_abnormal_ion_homeostasis0.96043315
146MP0002184_abnormal_innervation0.94777385
147MP0001764_abnormal_homeostasis0.94574098
148MP0003329_amyloid_beta_deposits0.93640381
149MP0003953_abnormal_hormone_level0.93636970
150MP0001348_abnormal_lacrimal_gland0.92806928
151MP0005636_abnormal_mineral_homeostasis0.92703128
152MP0001502_abnormal_circadian_rhythm0.92459616
153MP0002095_abnormal_skin_pigmentation0.91614552
154MP0000681_abnormal_thyroid_gland0.91329852
155MP0009765_abnormal_xenobiotic_induced0.89763955
156MP0000569_abnormal_digit_pigmentation0.89732253
157MP0006035_abnormal_mitochondrial_morpho0.89279577
158MP0004133_heterotaxia0.88540049
159MP0003633_abnormal_nervous_system0.88374603
160MP0003879_abnormal_hair_cell0.88067826
161MP0004742_abnormal_vestibular_system0.87251414
162MP0005423_abnormal_somatic_nervous0.87138509
163MP0002277_abnormal_respiratory_mucosa0.86624102
164MP0002069_abnormal_eating/drinking_beha0.84470413
165MP0006036_abnormal_mitochondrial_physio0.84365577
166MP0005451_abnormal_body_composition0.82275066
167MP0009643_abnormal_urine_homeostasis0.81145669
168MP0005584_abnormal_enzyme/coenzyme_acti0.79383906
169MP0000372_irregular_coat_pigmentation0.77554483
170MP0005084_abnormal_gallbladder_morpholo0.77225944
171MP0004264_abnormal_extraembryonic_tissu0.76490743
172MP0002229_neurodegeneration0.76084824
173MP0000703_abnormal_thymus_morphology0.74972758
174MP0002876_abnormal_thyroid_physiology0.74465344
175MP0009379_abnormal_foot_pigmentation0.74451528
176MP0004782_abnormal_surfactant_physiolog0.73730041
177MP0003075_altered_response_to0.73137538

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)4.31750757
2Chronic otitis media (HP:0000389)3.92945925
3Ketoacidosis (HP:0001993)3.79793448
4Recurrent abscess formation (HP:0002722)3.77210248
5Hypoglycemic coma (HP:0001325)3.76193429
6Recurrent bacterial skin infections (HP:0005406)3.68748327
7Hypoglycemic seizures (HP:0002173)3.61649971
8Hyperinsulinemic hypoglycemia (HP:0000825)3.57507021
9IgM deficiency (HP:0002850)3.48657454
10Large for gestational age (HP:0001520)3.46228572
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.44171112
12Type I transferrin isoform profile (HP:0003642)3.38721248
13Elevated erythrocyte sedimentation rate (HP:0003565)3.33389021
14Agammaglobulinemia (HP:0004432)3.28752612
15Abnormal protein glycosylation (HP:0012346)3.26844344
16Abnormal glycosylation (HP:0012345)3.26844344
17Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.26844344
18Abnormal protein N-linked glycosylation (HP:0012347)3.26844344
19Increased CSF lactate (HP:0002490)3.19420873
20Progressive neurologic deterioration (HP:0002344)3.16628085
21B lymphocytopenia (HP:0010976)3.13810962
22Abnormality of B cell number (HP:0010975)3.13810962
23Recurrent viral infections (HP:0004429)3.11490759
24Dysostosis multiplex (HP:0000943)3.03502116
25Recurrent bronchitis (HP:0002837)2.96583492
26Abnormality of macrophages (HP:0004311)2.90066809
27Recurrent skin infections (HP:0001581)2.89497749
28Reduced antithrombin III activity (HP:0001976)2.89335569
29Increased hepatocellular lipid droplets (HP:0006565)2.88360533
30Petechiae (HP:0000967)2.86444324
31Abnormality of T cell physiology (HP:0011840)2.85146660
32Abnormal number of erythroid precursors (HP:0012131)2.79090213
33Abnormality of cells of the erythroid lineage (HP:0012130)2.77910949
34Lipid accumulation in hepatocytes (HP:0006561)2.75447568
35Myositis (HP:0100614)2.74512431
36Eczematoid dermatitis (HP:0000976)2.73551389
37Ketosis (HP:0001946)2.73216165
38Meningitis (HP:0001287)2.73134710
39Cerebral edema (HP:0002181)2.70436986
40Abnormality of endocrine pancreas physiology (HP:0012093)2.69036937
41Abnormality of the pancreatic islet cells (HP:0006476)2.69036937
42Thrombocytosis (HP:0001894)2.68390753
43EEG with generalized epileptiform discharges (HP:0011198)2.65169360
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.62551445
45Hypsarrhythmia (HP:0002521)2.62368491
46Hypomagnesemia (HP:0002917)2.62341931
47Medial flaring of the eyebrow (HP:0010747)2.60218129
48Symptomatic seizures (HP:0011145)2.59829353
49Epileptiform EEG discharges (HP:0011182)2.58574301
50Cellulitis (HP:0100658)2.57296367
51Methylmalonic acidemia (HP:0002912)2.55106718
523-Methylglutaconic aciduria (HP:0003535)2.47902932
53T lymphocytopenia (HP:0005403)2.45014019
54Inflammation of the large intestine (HP:0002037)2.43556248
55Mitochondrial inheritance (HP:0001427)2.42699777
56Recurrent fungal infections (HP:0002841)2.42169260
57Abnormality of T cell number (HP:0011839)2.41364585
58Acute necrotizing encephalopathy (HP:0006965)2.40530406
59Hepatocellular necrosis (HP:0001404)2.39722064
60Abnormality of T cells (HP:0002843)2.39121572
61Abnormality of urine glucose concentration (HP:0011016)2.39119657
62Glycosuria (HP:0003076)2.39119657
63Neutropenia (HP:0001875)2.38188491
64Myokymia (HP:0002411)2.37116197
65Gastrointestinal stroma tumor (HP:0100723)2.36547069
66Agitation (HP:0000713)2.35020411
67Poor suck (HP:0002033)2.34561011
68Methylmalonic aciduria (HP:0012120)2.29511389
69Hyperglycemia (HP:0003074)2.29315409
70Hepatic necrosis (HP:0002605)2.28080232
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.27830965
72Increased cerebral lipofuscin (HP:0011813)2.26841098
73Gastrointestinal inflammation (HP:0004386)2.26658593
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.25952451
75Renal Fanconi syndrome (HP:0001994)2.24784178
76Abnormal mitochondria in muscle tissue (HP:0008316)2.24427088
77Muscular hypotonia of the trunk (HP:0008936)2.23576765
78Neurofibrillary tangles (HP:0002185)2.21695276
79Chronic mucocutaneous candidiasis (HP:0002728)2.21079717
80Recurrent cutaneous fungal infections (HP:0011370)2.21079717
81Intestinal atresia (HP:0011100)2.20411320
82Respiratory failure (HP:0002878)2.20303319
83Abnormal delayed hypersensitivity skin test (HP:0002963)2.19940167
84Mucopolysacchariduria (HP:0008155)2.19869669
85Urinary glycosaminoglycan excretion (HP:0003541)2.19869669
86Aplastic anemia (HP:0001915)2.19474746
87Stomatitis (HP:0010280)2.19207240
88Abnormality of vitamin B metabolism (HP:0004340)2.19070372
89Pancreatic islet-cell hyperplasia (HP:0004510)2.18746217
90Abnormality of midbrain morphology (HP:0002418)2.18495868
91Molar tooth sign on MRI (HP:0002419)2.18495868
92Panhypogammaglobulinemia (HP:0003139)2.18149489
93Vasculitis (HP:0002633)2.16572586
94Hyperphosphaturia (HP:0003109)2.16063704
95Cerebral hypomyelination (HP:0006808)2.15953001
96Colitis (HP:0002583)2.15642147
97Gait imbalance (HP:0002141)2.15281314
98Hepatosplenomegaly (HP:0001433)2.13929441
99Degeneration of the lateral corticospinal tracts (HP:0002314)2.13857545
100Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13857545
101Obstructive lung disease (HP:0006536)2.13597181
102Chronic obstructive pulmonary disease (HP:0006510)2.13597181
103IgG deficiency (HP:0004315)2.10973023
104Chronic diarrhea (HP:0002028)2.10494335
105Axonal loss (HP:0003447)2.10456784
106Segmental peripheral demyelination/remyelination (HP:0003481)2.09206409
107Acute encephalopathy (HP:0006846)2.09206274
108Increased intramyocellular lipid droplets (HP:0012240)2.09008110
109Recurrent pneumonia (HP:0006532)2.08762616
110Limb dystonia (HP:0002451)2.08437551
111Slow saccadic eye movements (HP:0000514)2.07160927
112Lactic acidosis (HP:0003128)2.06839881
113Congenital stationary night blindness (HP:0007642)2.06507413
114Abnormality of magnesium homeostasis (HP:0004921)2.05649946
115Retinal dysplasia (HP:0007973)2.05060717
116Fatigue (HP:0012378)2.05057274
117Loss of speech (HP:0002371)2.05021104
118Aplasia/Hypoplasia of the fovea (HP:0008060)2.04571156
119Hypoplasia of the fovea (HP:0007750)2.04571156
120Congenital primary aphakia (HP:0007707)2.03786650
121Optic disc pallor (HP:0000543)2.03604523
122Hypothermia (HP:0002045)2.02904637
123Anxiety (HP:0000739)2.02838148
124Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02732838
125Pancreatic cysts (HP:0001737)2.01643143
126Recurrent sinusitis (HP:0011108)2.01177007
127Interstitial pulmonary disease (HP:0006530)2.00906075
128Abnormality of glycolipid metabolism (HP:0010969)1.99727556
129Abnormality of liposaccharide metabolism (HP:0010968)1.99727556
130Abnormality of glycosphingolipid metabolism (HP:0004343)1.99727556
131Polyphagia (HP:0002591)1.99471901
132Peripheral hypomyelination (HP:0007182)1.99252301
133Hypoplasia of the thymus (HP:0000778)1.98321464
134Decreased circulating renin level (HP:0003351)1.98309818
135Epileptic encephalopathy (HP:0200134)1.95771245
136Lethargy (HP:0001254)1.95085635
137CNS hypomyelination (HP:0003429)1.94476180
138Insulin-resistant diabetes mellitus (HP:0000831)1.93706191
139Leukodystrophy (HP:0002415)1.93040454
140Abnormality of vitamin metabolism (HP:0100508)1.92454833
141Progressive macrocephaly (HP:0004481)1.92230843
142Episodic fever (HP:0001954)1.91984515
143Poor head control (HP:0002421)1.91880339
144Aplasia/hypoplasia of the uterus (HP:0008684)1.91567024
145Hypergammaglobulinemia (HP:0010702)1.91508653
146Increased serum lactate (HP:0002151)1.91495824
147Abnormality of renal resorption (HP:0011038)1.91221013
148Abnormality of the labia minora (HP:0012880)1.90939404
149Generalized aminoaciduria (HP:0002909)1.90769740
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90719026
151Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90719026
152Abnormality of the renal cortex (HP:0011035)1.90601915
153Optic neuritis (HP:0100653)1.90333975
154Retrobulbar optic neuritis (HP:0100654)1.90333975
155Late onset (HP:0003584)1.90110950
156Dicarboxylic aciduria (HP:0003215)1.90020988
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90020988
158Skin rash (HP:0000988)1.89509016
159Renal cortical cysts (HP:0000803)1.89352253
160Hemiparesis (HP:0001269)1.88759037
161Abolished electroretinogram (ERG) (HP:0000550)1.88413855
162Sepsis (HP:0100806)1.88370996
163Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87979893
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87755594
165Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87755594
166Nephrogenic diabetes insipidus (HP:0009806)1.87411076
167Hypobetalipoproteinemia (HP:0003563)1.87356409
168Gaze-evoked nystagmus (HP:0000640)1.86424261
169Abnormality of renin-angiotensin system (HP:0000847)1.86028767
170Pancreatic fibrosis (HP:0100732)1.84604309
171Febrile seizures (HP:0002373)1.83217443
172Increased circulating renin level (HP:0000848)1.83090761
173Prominent metopic ridge (HP:0005487)1.82128992
174Abnormality of the fovea (HP:0000493)1.79435137
175True hermaphroditism (HP:0010459)1.79264176
176Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78176410
177Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77912142
178Polydipsia (HP:0001959)1.77795204
179Abnormal drinking behavior (HP:0030082)1.77795204
180Nephronophthisis (HP:0000090)1.77018915
181Congenital malformation of the right heart (HP:0011723)1.72925552
182Double outlet right ventricle (HP:0001719)1.72925552
183Type II lissencephaly (HP:0007260)1.71890118
184Abnormality of the metopic suture (HP:0005556)1.70600850
185Increased muscle lipid content (HP:0009058)1.67427739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K12.96106918
2MAPKAPK52.88348633
3TAOK32.80448328
4NME22.67464411
5WNK32.65514821
6MAP4K22.64634260
7MAP3K42.63378442
8IRAK42.57401306
9TESK22.38978647
10STK392.31782023
11MST42.21189861
12STK162.20284375
13TEC2.17760354
14ERN12.16303110
15KIT2.10281174
16EIF2AK32.08439650
17CASK2.07135436
18MAP2K72.05303137
19GRK12.01162990
20BLK2.00526752
21EPHB11.96321537
22ERBB31.95539969
23PINK11.93907001
24BCKDK1.92647156
25TRIM281.89527749
26BTK1.84897494
27DAPK21.80795735
28IRAK31.78992608
29TXK1.78919418
30MAP3K141.77649366
31TBK11.74270160
32SYK1.68772541
33NTRK31.68294947
34BCR1.68011262
35CDK191.65910146
36CSF1R1.62506026
37FGFR21.60184346
38DYRK21.59384000
39PAK31.57269618
40ACVR1B1.56833854
41RIPK41.56730406
42IKBKE1.53934200
43CSNK1G21.52823224
44ZAP701.47675925
45TYK21.46761397
46MUSK1.46143441
47PIM21.44004209
48PRKCG1.42708297
49OXSR11.42097545
50FLT31.41155913
51MAP3K131.38242648
52PHKG21.36934444
53PHKG11.36934444
54JAK31.31532431
55TSSK61.31023825
56MAP3K121.29275092
57ARAF1.29273206
58CLK11.27520958
59MARK11.25616748
60TESK11.24170888
61ITK1.22150293
62MAPK151.20842539
63MAPK131.17988348
64PBK1.17402269
65PKN11.12072581
66SCYL21.06858091
67LCK1.05712870
68PLK21.05164501
69LYN1.05104075
70VRK11.04417862
71HIPK21.03437305
72TNIK1.03362557
73NUAK11.03341995
74FES1.01554110
75MAP2K21.00925054
76PRKCE0.98843756
77IKBKB0.97726994
78CAMKK20.96715716
79PNCK0.94660818
80MAP2K60.94267079
81MINK10.90328099
82PIK3CG0.90273891
83GRK60.87104774
84EPHA30.86656859
85NME10.86232244
86JAK10.85520916
87DAPK10.81317403
88STK38L0.79494186
89ADRBK20.79223072
90LRRK20.79120389
91PRKCQ0.78584039
92TRPM70.74984640
93CSNK1G30.73896246
94PASK0.73314335
95CAMK2B0.72953967
96FER0.72105264
97FGFR30.70002682
98ZAK0.67647121
99RPS6KA50.67104640
100NLK0.66861949
101TAOK10.66508826
102CSNK1A10.66066889
103CAMK2A0.65703310
104PRKCI0.65538537
105CAMK2D0.64366267
106NEK10.64339111
107MKNK20.64189206
108INSRR0.62879429
109NTRK20.62873817
110PLK30.62065036
111LIMK10.60375779
112MAP3K10.58348529
113KDR0.57131441
114PRKG20.56850673
115AKT30.56648129
116UHMK10.55220583
117MATK0.55120644
118PRKACA0.54671480
119MAP2K40.54652588
120MAPKAPK20.54458052
121CSNK1A1L0.51941309
122HCK0.51887141
123CDK30.51804040
124IRAK10.51490349
125TNK20.51016534
126BMPR20.50063748
127CSNK1E0.49990452
128PDK20.49048473
129FRK0.47861622
130RAF10.47103718
131CDK50.46970117
132TLK10.46142707
133CAMK2G0.46116801
134PRKAA10.44814205
135WNK40.43361470
136PRKCD0.43343542
137MAPKAPK30.41907950
138MET0.41899704
139BRSK20.41480875
140CSK0.41153401
141ILK0.40815532
142BRAF0.40651760
143BUB10.40408322
144JAK20.40374177
145CSNK2A20.40111989
146EIF2AK10.40057922
147NTRK10.39873989
148DYRK30.39617909
149IRAK20.39476988
150PRKCH0.39018201
151EPHA40.38696436
152SGK4940.38156869
153SGK2230.38156869
154GRK70.37981408
155PRKCA0.37303869
156PRKG10.36596789
157MAP3K20.36388475
158PRKCZ0.36343437
159ADRBK10.36065172
160SGK10.35675084
161VRK20.35420546
162CSNK1G10.35100387
163BMPR1B0.34344893
164CSNK1D0.34327228
165CSNK2A10.33823660
166PRKACB0.31260856
167MAP3K90.30977168

Predicted pathways (KEGG)

RankGene SetZ-score
1* Protein export_Homo sapiens_hsa030605.70134589
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.02664928
3Butanoate metabolism_Homo sapiens_hsa006502.70313626
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.50218918
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48542543
6Primary immunodeficiency_Homo sapiens_hsa053402.47685854
7Other glycan degradation_Homo sapiens_hsa005112.47447102
8Folate biosynthesis_Homo sapiens_hsa007902.46885749
9Ribosome_Homo sapiens_hsa030102.36896421
10Sulfur metabolism_Homo sapiens_hsa009202.34313749
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31001407
12SNARE interactions in vesicular transport_Homo sapiens_hsa041302.24633133
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.12702755
14Oxidative phosphorylation_Homo sapiens_hsa001901.94882387
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.94791561
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85614242
17Lysosome_Homo sapiens_hsa041421.84803508
18Pancreatic secretion_Homo sapiens_hsa049721.84374140
19Fatty acid elongation_Homo sapiens_hsa000621.81899484
20Vitamin B6 metabolism_Homo sapiens_hsa007501.80814614
21N-Glycan biosynthesis_Homo sapiens_hsa005101.79335414
22Asthma_Homo sapiens_hsa053101.77185881
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72676481
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60748564
25Insulin secretion_Homo sapiens_hsa049111.57262876
26Parkinsons disease_Homo sapiens_hsa050121.56660976
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56403339
28Ether lipid metabolism_Homo sapiens_hsa005651.54923984
29Vibrio cholerae infection_Homo sapiens_hsa051101.54380698
30Tryptophan metabolism_Homo sapiens_hsa003801.54368154
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.52297686
32Propanoate metabolism_Homo sapiens_hsa006401.51391106
33Allograft rejection_Homo sapiens_hsa053301.49591692
34Peroxisome_Homo sapiens_hsa041461.47776616
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44252438
36Synaptic vesicle cycle_Homo sapiens_hsa047211.43633814
37B cell receptor signaling pathway_Homo sapiens_hsa046621.42663939
38Nicotine addiction_Homo sapiens_hsa050331.41341906
39Antigen processing and presentation_Homo sapiens_hsa046121.40822367
40Hematopoietic cell lineage_Homo sapiens_hsa046401.40444248
41Leishmaniasis_Homo sapiens_hsa051401.38148867
42Alzheimers disease_Homo sapiens_hsa050101.36322193
43Linoleic acid metabolism_Homo sapiens_hsa005911.33978037
44Histidine metabolism_Homo sapiens_hsa003401.31547069
45Steroid biosynthesis_Homo sapiens_hsa001001.31339625
46Sphingolipid metabolism_Homo sapiens_hsa006001.30260908
47beta-Alanine metabolism_Homo sapiens_hsa004101.24195397
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22177730
49Phototransduction_Homo sapiens_hsa047441.21804029
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21303059
51Cardiac muscle contraction_Homo sapiens_hsa042601.20697952
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18876075
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16646693
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14168135
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.13681114
56Autoimmune thyroid disease_Homo sapiens_hsa053201.13335785
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10254843
58Caffeine metabolism_Homo sapiens_hsa002321.09643320
59Proteasome_Homo sapiens_hsa030501.07988795
60GABAergic synapse_Homo sapiens_hsa047271.07693125
61Basal transcription factors_Homo sapiens_hsa030221.06571210
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05145113
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04269658
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00968004
65Fatty acid metabolism_Homo sapiens_hsa012120.99727103
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98768626
67Fatty acid degradation_Homo sapiens_hsa000710.98621884
68Selenocompound metabolism_Homo sapiens_hsa004500.97374149
69Rheumatoid arthritis_Homo sapiens_hsa053230.96786949
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.95078627
71Pertussis_Homo sapiens_hsa051330.94677190
72Graft-versus-host disease_Homo sapiens_hsa053320.94666940
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93004841
74Arachidonic acid metabolism_Homo sapiens_hsa005900.91617522
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90098292
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89334648
77Measles_Homo sapiens_hsa051620.88742615
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88534241
79Regulation of autophagy_Homo sapiens_hsa041400.88378981
80Osteoclast differentiation_Homo sapiens_hsa043800.85547551
81Retinol metabolism_Homo sapiens_hsa008300.84970743
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84394039
83Non-homologous end-joining_Homo sapiens_hsa034500.83980277
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82217508
85Phagosome_Homo sapiens_hsa041450.81051318
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79347796
87Renin-angiotensin system_Homo sapiens_hsa046140.78427945
88RNA degradation_Homo sapiens_hsa030180.75698810
89Type I diabetes mellitus_Homo sapiens_hsa049400.75227279
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74529457
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74508537
92Mineral absorption_Homo sapiens_hsa049780.74040056
93Tuberculosis_Homo sapiens_hsa051520.73152830
94Chemical carcinogenesis_Homo sapiens_hsa052040.72150895
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71276254
96Taste transduction_Homo sapiens_hsa047420.70793618
97Serotonergic synapse_Homo sapiens_hsa047260.70617602
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69315779
99Circadian rhythm_Homo sapiens_hsa047100.68587616
100Legionellosis_Homo sapiens_hsa051340.68226184
101DNA replication_Homo sapiens_hsa030300.67418348
102Dopaminergic synapse_Homo sapiens_hsa047280.66395484
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.65225362
104Morphine addiction_Homo sapiens_hsa050320.64004989
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.63071702
106Amphetamine addiction_Homo sapiens_hsa050310.62200811
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62091284
108Nitrogen metabolism_Homo sapiens_hsa009100.60927628
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60801353
110T cell receptor signaling pathway_Homo sapiens_hsa046600.60581629
111Collecting duct acid secretion_Homo sapiens_hsa049660.59565259
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58160280
113Influenza A_Homo sapiens_hsa051640.57888320
114One carbon pool by folate_Homo sapiens_hsa006700.57656229
115RNA polymerase_Homo sapiens_hsa030200.56773596
116Huntingtons disease_Homo sapiens_hsa050160.56208229
117Fat digestion and absorption_Homo sapiens_hsa049750.54925574
118Chemokine signaling pathway_Homo sapiens_hsa040620.54078548
119Pyruvate metabolism_Homo sapiens_hsa006200.53151919
120Circadian entrainment_Homo sapiens_hsa047130.53068962
121Type II diabetes mellitus_Homo sapiens_hsa049300.52452571
122Tyrosine metabolism_Homo sapiens_hsa003500.50463679
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48045741
124Glutamatergic synapse_Homo sapiens_hsa047240.47830003
125Pyrimidine metabolism_Homo sapiens_hsa002400.47043306
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46731473
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46343882
128Shigellosis_Homo sapiens_hsa051310.45378800
129Purine metabolism_Homo sapiens_hsa002300.45297374
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44671345
131Metabolic pathways_Homo sapiens_hsa011000.42743162
132Base excision repair_Homo sapiens_hsa034100.42573640
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41954323
134Malaria_Homo sapiens_hsa051440.41667351
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41257155
136Herpes simplex infection_Homo sapiens_hsa051680.41046084
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.40463298
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.38581068
139Hepatitis C_Homo sapiens_hsa051600.37653686
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.37313419
141Sulfur relay system_Homo sapiens_hsa041220.36520535
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36226112
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35953034
144Arginine biosynthesis_Homo sapiens_hsa002200.35593809
145Toxoplasmosis_Homo sapiens_hsa051450.35419676
146Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35282042
147Cocaine addiction_Homo sapiens_hsa050300.35277359
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34345978
149Pentose phosphate pathway_Homo sapiens_hsa000300.32782682
150Mismatch repair_Homo sapiens_hsa034300.31659970
151Protein digestion and absorption_Homo sapiens_hsa049740.31484495
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31268809
153Glutathione metabolism_Homo sapiens_hsa004800.30577415
154Salmonella infection_Homo sapiens_hsa051320.30418169
155ABC transporters_Homo sapiens_hsa020100.30080433
156Apoptosis_Homo sapiens_hsa042100.29056836
157Arginine and proline metabolism_Homo sapiens_hsa003300.26799795
158Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26600105
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26206343

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